Stephanie Barrere-Lemaire

Identifiants chercheurs

IdHAL :

stephanie-barrere-lemaire

ORCID :

0000-0002-3742-6975

IdRef :

165155175

Présentation

Mon activité de recherche concerne la cardioprotection au cours de l'ischémie-reperfusion myocardique. En effet, à ce jour, 30 ans après les premières descriptions des lésions de reperfusion, il n’existe toujours pas de traitement efficace permettant de les inhiber spécifiquement. En effet, seules les lésions d’ischémie sont prises en charge grâce à la reperfusion myocardique (réouverture de l’artère occluse) par thrombolyse ou par angioplastie coronaire par le cardiologue interventionnel. Ainsi, mes projets de recherche sont focalisés d’une part, sur l’étude des mécanismes des lésions de reperfusion et d’autre part, sur l’étude des mécanismes endogènes de cardioprotection afin d’identifier les cibles potentielles pour la mise au point d’outils thérapeutiques.

Publications

Article dans une revue (30)

Enhancing WRAP‐based Nanoparticles for siRNA Delivery in pH‐Sensitive Environments Giulia Di Gregorio,Coélio Vallée,Karidia Konate,Clémentine Teko-Agbo,Thania Hammoumet al. ChemMedChem, 2025, 20 (11), pp.e202400885. ⟨10.1002/cmdc.202400885⟩ Article dans une revue hal-04992374v1
Mesenchymal stromal cells for improvement of cardiac function following acute myocardial infarction: a matter of timing Stéphanie Barrère-Lemaire,Anne Vincent,Christian Jorgensen,Christophe Piot,Joël Nargeotet al. Physiological Reviews, 2024, 104 (2), pp.659-725. ⟨10.1152/physrev.00009.2023⟩ Article dans une revue (article de synthèse) hal-04189475v1
Selective blockade of Ca$_V$1.2 (α1C) versus Ca$_V$1.3 (α1D) L-type calcium channels by the black mamba toxin calciseptine Pietro Mesirca,Jean Chemin,Christian Barrère,Eleonora Torre,Laura Gallotet al. Nature Communications, 2024, 15 (1), pp.54. ⟨10.1038/s41467-023-43502-w⟩ Article dans une revue hal-04385916v1
Editorial: New strategies to inhibit cell death in myocardial ischemia-reperfusion injury: how to succeed? Volume II Sarawut Kumphune,Christophe Piot,Stéphanie Barrère-Lemaire Frontiers in Cardiovascular Medicine, 2023, 10, pp.1260800. ⟨10.3389/fcvm.2023.1260800⟩ Article dans une revue hal-04189393v1
Heart rate reduction after genetic ablation of L-type Cav1.3 channels induces cardioprotection against ischemia-reperfusion injury Viviana Delgado-Betancourt,Kroekkiat Chinda,Pietro Mesirca,Christian Barrère,Aurélie Covinheset al. Frontiers in Cardiovascular Medicine, 2023, 10, pp.1134503. ⟨10.3389/fcvm.2023.1134503⟩ Article dans une revue hal-04184437v1
Therapeutic Peptides to Treat Myocardial Ischemia-Reperfusion Injury Carlota Fernandez Rico,Karidia Konate,Emilie Josse,Joël Nargeot,Stéphanie Barrère-Lemaireet al. Frontiers in Cardiovascular Medicine, 2022, 9, pp.792885. ⟨10.3389/fcvm.2022.792885⟩ Article dans une revue hal-03601220v1
Editorial: New Strategies to Inhibit Cell Death in Myocardial Ischemia-Reperfusion Injury: How to Succeed? Stéphanie Barrère-Lemaire,Christophe Piot,Sarawut Kumphune Frontiers in Cardiovascular Medicine, 2022, 9, pp.918902. ⟨10.3389/fcvm.2022.918902⟩ Article dans une revue hal-03739905v1
PPARβ/δ priming enhances the anti-apoptotic and therapeutic properties of mesenchymal stromal cells in myocardial ischemia–reperfusion injury Charlotte Sarre,Rafael Contreras-Lopez,Nitirut Nernpermpisooth,Christian Barrère,Sarah Bahraouiet al. Stem Cell Research and Therapy, 2022, 13 (1), pp.167. ⟨10.1186/s13287-022-02840-0⟩ Article dans une revue (data paper) hal-03653227v1
Post-Ischemic Treatment of Recombinant Human Secretory Leukocyte Protease Inhibitor (rhSLPI) Reduced Myocardial Ischemia/Reperfusion Injury Podsawee Mongkolpathumrat,Anusak Kijtawornrat,Eakkapote Prompunt,Aussara Panya,Nipon Chattipakornet al. Biomedicines, 2021, 9 (4), pp.422. ⟨10.3390/biomedicines9040422⟩ Article dans une revue hal-03370507v1
PPARβ/δ Is Required for Mesenchymal Stem Cell Cardioprotective Effects Independently of Their Anti-inflammatory Properties in Myocardial Ischemia-Reperfusion Injury Nitirut Nernpermpisooth,Charlotte Sarre,Christian Barrere,Rafaël Contreras,Patricia Luz-Crawfordet al. Frontiers in Cardiovascular Medicine, 2021, 8, pp.681002. ⟨10.3389/fcvm.2021.681002⟩ Article dans une revue hal-03644844v1
Concomitant genetic ablation of L-type Cav1.3 (α1D) and T-type Cav3.1 (α1G) Ca2+ channels disrupts heart automaticity Matthias Baudot,Eleonora Torre,Isabelle Bidaud,Julien Louradour,Angelo G Torrenteet al. Scientific Reports, 2020, 10 (1), pp.18906. ⟨10.1038/s41598-020-76049-7⟩ Article dans une revue hal-03013849v1
Anti-apoptotic peptide for long term cardioprotection in a mouse model of myocardial ischemia–reperfusion injury Aurélie Covinhes,Laura Gallot,Christian Barrère,Anne Vincent,Catherine Sportouchet al. Scientific Reports, 2020, 10 (1), pp.18116. ⟨10.1038/s41598-020-75154-x⟩ Article dans une revue hal-02982345v1
A novel therapeutic peptide targeting myocardial reperfusion injury Prisca Boisguerin,Aurélie Covinhes,Laura Gallot,Christian Barrère,Anne Vincentet al. Cardiovascular Research, 2020, 116 (3), pp.633-644. ⟨10.1093/cvr/cvz145⟩ Article dans une revue hal-02396806v1
Cardioprotective effects of a synthetic peptide targeting the extrinsic apoptotic pathway in a mouse model of ischemia-reperfusion P. Boisguerin,Aurélie Covinhes,Laura Gallot,Christian Barrère,Anne Vincentet al. Archives of cardiovascular diseases, 2019, 11 (2), pp.211. ⟨10.1016/j.acvdsp.2019.02.065⟩ Article dans une revue hal-02404659v1
Combination of metformin and p38 MAPK inhibitor, SB203580, reduced myocardial ischemia/reperfusion injury in non‑obese type 2 diabetic Goto‑Kakizaki rats Jantira Sanit,Eakkapote Prompunt,Punyanuch Adulyaritthikul,Nuttikarn Nokkaew,Podsawee Mongkolpathumratet al. Experimental and Therapeutic Medicine, 2019, 18 (3), pp.1701-1714. ⟨10.3892/etm.2019.7763⟩ Article dans une revue hal-02506280v1
Comparative regenerative properties of mesenchymal stem cells isolated from MRL (Murphy Roths Large) versus C57Bl6 mice C. Sarre,G. Tejedor,P. Gonzalez,S. Bahraoui,Christian Barrèreet al. Archives of Cardiovascular Diseases Supplements, 2019, 11 (2), pp.244-245. ⟨10.1016/j.acvdsp.2019.02.137⟩ Article dans une revue hal-02404686v1
The cardioprotective effects of secretory leukocyte protease inhibitor against myocardial ischemia/reperfusion injury Eakkapote Prompunt,Jantira Sanit,Stéphanie Barrère-Lemaire,Joël Nargeot,Hannah Noordaliet al. Experimental and Therapeutic Medicine, 2018, 15 (6), pp.5231-5242. ⟨10.3892/etm.2018.6097⟩ Article dans une revue hal-02073198v1
Cardiac mGluR1 metabotropic receptors in cardioprotection Anne Vincent,Catherine Sportouch,Aurélie Covinhes,Christian Barrère,Laura Gallotet al. Cardiovascular Research, 2017, 113 (6), pp.644--655. ⟨10.1093/cvr/cvx024⟩ Article dans une revue hal-01875241v1
Acute and long-term cardioprotective effects of the Traditional Chinese Medicine MLC901 against myocardial ischemia-reperfusion injury in mice Anne Vincent,Aurélie Covinhes,Christian Barrère,Laura Gallot,Soulit Thoumalaet al. Scientific Reports, 2017, 7 (1), pp.14701. ⟨10.1038/s41598-017-14822-x⟩ Article dans une revue hal-02506308v1
PEGylation rate influences peptide-based nanoparticles mediated siRNA delivery in vitro and in vivo Gudrun Aldrian,Anaïs Vaissière,Karidia Konate,Quentin Seisel,Eric Vivèset al. Journal of Controlled Release, 2017, 256, pp.79-91. ⟨10.1016/j.jconrel.2017.04.012⟩ Article dans une revue hal-02197250v1
New Insights in Research About Acute Ischemic Myocardial Injury and Inflammation Anne Vincent,Benoit Lattuca,Nolwenn Merlet,Catherine Sportouch-Dukhan,Stéphanie Barrère-Lemaire Antiinflammatory and Antiallergy Agents in Medicinal Chemistry, 2013, 12 (1), pp.47-54. ⟨10.2174/1871523011312010007⟩ Article dans une revue istex hal-02506302v1
Down-regulation of the transcription factor ZAC1 upon pre- and postconditioning protects against I/R injury in the mouse myocardium Anne Vincent,Gérald Gahide,Catherine Sportouch,Aurélie Covinhes,Alicia Franck-Micloet al. Cardiovascular Research, 2012, 94 (2), pp.351-358. ⟨10.1093/cvr/cvr310⟩ Article dans une revue hal-02506277v1
Exchange protein activated by cAMP (Epac) mediates cAMP activation of p38 MAPK and modulation of Ca2+-dependent K+ channels in cerebellar neurons Jeanne Ster,Frédéric de Bock,Nathalie C. Guérineau,Andrea Janossy,Stéphanie Barrère-Lemaireet al. Proceedings of the National Academy of Sciences of the United States of America, 2007, 104 (7), pp.2519-2524. ⟨10.1073/pnas.0611031104⟩ Article dans une revue hal-02484623v1
Myocardial expression of a dominant-negative form of Daxx decreases infarct size and attenuates apoptosis in an in vivo mouse model of ischemia/reperfusion injury. François Roubille,Stéphane Combes,Juani Leal-Sanchez,Christian Barrère,Frédéric Cransacet al. Circulation, 2007, 116 (23), pp.2709-17. ⟨10.1161/CIRCULATIONAHA.107.694844⟩ Article dans une revue hal-00318924v1
Differentiated rabbit prostatic stromal cells in primary culture display functional alpha1A-adrenoceptors. Delphine Boulbès,Armelle Choquet,Stéphanie Barrère-Lemaire,Pierre Costa,Laurent Soustelleet al. Neurourology and Urodynamics, 2006, 25 (2), pp.168-78. ⟨10.1002/nau.20196⟩ Article dans une revue istex hal-00201272v1
Aldosterone increases T-type calcium channel expression and in vitro beating frequency in neonatal rat cardiomyocytes N. Lalevee,M. C. Rebsamen,S. Barrere-Lemaire,E. Perrier,Joël Nargeotet al. Cardiovascular Research, 2005, 67 (2), pp.216-224. ⟨10.1016/j.cardiores.2005.05.009⟩ Article dans une revue hal-00117252v1
Morphine mimics the antiapoptotic effect of preconditioning via an Ins(1,4,5)P3 signaling pathway in rat ventricular myocytes Stéphanie Barrère-Lemaire,N. Combes,C. Sportouch-Dukhan,S. Richard,Joël Nargeotet al. AJP - Heart and Circulatory Physiology, 2005, 288, pp.H83-88. ⟨10.1152/ajpheart.00881.2003⟩ Article dans une revue hal-00016897v1
Effects of amiodarone and dronedarone on voltage-dependent sodium current in human cardiomyocytes. N. Lalevée,Joël Nargeot,S. Barrere-Lemaire,P. Gautier,S. Richard Journal of Cardiovascular Electrophysiology, 2003, 14, pp.885-890 Article dans une revue hal-00311209v1
Cloning and expression of human 5-HT4S receptors. Effect of receptor density on their coupling to adenylyl cyclase Sylvie Claeysen,Patrick Faye,Michèle Sebben,Stéphanie Barrère-Lemaire,Joël Bockaertet al. NeuroReport, 1997, 8 (15), pp.3189-3196. ⟨10.1097/00001756-199710200-00002⟩ Article dans une revue hal-02491123v1
Assignment of 5-Hydroxytryptamine Receptor (HTR4) to human chromosome 5 bands q31→q33 by in situ hybridization S. Claeysen,Patrick Faye,Michèle Sebben,Stéphanie Barrère-Lemaire,Joel Bockaertet al. Cytogenetic and Genome Research, 1997, 78 (2), pp.133-134. ⟨10.1159/000134646⟩ Article dans une revue hal-02491196v1