Stephanie Passot
Publications
Publications
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The challenge of preserving beneficial bacteria: strategies and tools to identify stress mechanisms and sites of cell damage induced by dehydration processesISLFD 2024 - 10Th International Symposium on Lyophilization of Pharmaceuticals, May 2024, Turin (IT), Italy |
Perchlorate salts lower the vitrification point of Bacillus subtilis to temperatures lower than those expected beneath the Martian south poleEANA - European Astrobiology Network Association, Universidad Carlos III de Madrid Ronda de Toledo, Sep 2023, Madrid, Spain |
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Perchlorate salts lower the vitrification point of Bacillus Subtilis to temperatures lower than those expected beneath the Martian south poleEuropean Astrobiology Network Association, Sep 2023, Madrid, Spain |
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Environmental performances of the production of dried lactic acid bacteria concentrates protected by fructo-oligosaccharides ICEF14, June 20 th to 23 rd 2023, Nantes, FranceInternational Congress on Engineering and Food, Jun 2023, Nantes, France |
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Differential scanning calorimetry applied to the preservation of bacteria and mammalian cellsJCAT53 - 53èmes Journées de Calorimétrie et d'Analyse Thermique, May 2023, Palaiseau, France |
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Perchlorate brines in the Martian deep subsurface and the low temperature limit for life.Astrobiology Science Conference, 2022, Atlanta, United States |
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Fructose oligosaccharides as a novel cryoprotectant for mammalian cells59th Annual Meeting of the Society for Cryobiology, Jul 2020, Inconnue, France. pp.174 |
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Avancées récentes sur la production et la stabilisation de bactéries lactiques à haute fonctionnalitéCBL 2019 - 22. Colloque du Club des Bactéries Lactiques, Jun 2019, Caen, France |
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Development of a simplified lipid model of bacterial membrane to investigate specific interactions with oligosaccharides56. Annual Meeting of the Society for Cryobiology, Jul 2019, San Diego, CA, United States. pp.173, ⟨10.1016/j.cryobiol.2019.10.109⟩ |
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Complementary analytical approaches improving knowledge on lactic acid bacteria cryoresistance56. Annual Meeting of the Society for Cryobiology, Jul 2019, San Diego, CA, United States. 166-166 p., ⟨10.1016/j.cryobiol.2019.10.086⟩ |
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Physical events during cryopreservation: consequences on cells’ post-thaw performance and on cryobiological protocols optimisation9. International Symposium on Lyophilization of Pharmaceuticals ISLFD, Sep 2019, Ghent, Belgium |
Recent advances on production and stabilization of lactic acid bacteria with high de functionalityCBL 2019 - 22. Colloque du Club des Bactéries Lactiques, Jun 2019, Caen, France |
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Methodological approach towards environmentally friendly processes for preserving lactic acid bacteriaClub des Bactéries Lactiques, Jun 2019, Caen, France |
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Use of a multi-vial mathematical model to design freeze-drying cycles for pharmaceuticals at known risk of failure21. International Drying Symposium, Sep 2018, Valencia, Spain. ⟨10.4995/IDS2018.2018.7421⟩ |
Can the desorption kinetics explain the residual moisture content heterogeneity observed in pharmaceuticals freeze-drying process?6. European Drying Conference: EuroDrying 2017, Jun 2017, Liège, Belgium |
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Eco-conception des bio‐procédés : exemple des bactéries lactiques stabiliséesMétaséminaire CEPIA 2017, INRA-CEPIA, Mar 2017, Massy, France |
Stabilisation d'écosystèmes microbiens fromagers : preuve de conceptSociété Française de Microbiologie, Oct 2017, Paris, France |
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Les bactéries lactiques sous la lumière du synchrotron pour comprendre les mécanismes de cryotoléranceSociété Française de Microbiologie, Oct 2017, Paris, France |
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Finite elements model of heat transfer predicts the edge vial effect in different freeze-drying configurations2016 CPPR Conference Freeze-Drying of Pharmaceuticals and Biologicals, Jul 2016, Breckenridge, United States |
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Mapping membrane fluidity in single bacterial cells to study the impact of cryopreservation and its related stresses2. International Conference on Physics and Biological Systems 2016, Oct 2016, Gif-sur-Yvette, France |
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Freeze-drying control by taking into account environmental considerations (communication orale)FoodFactory, Oct 2016, Laval, France |
How to manage scale-up using the design space approach2016 PDA Conference, Pharmaceutical Freeze Drying Technology, PDA., Sep 2016, Strasbourg, France |
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Production of stabilized lactic acid bacteria viewed from a life cycle assessment perspectiveLCA Food 2016, Oct 2016, Dublin, Ireland |
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Eco-design of food and bio-processes: Example of production of stabilized lactic acid bacteriaLecture at WUR, Sep 2016, Wageningen, Netherlands |
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Life cycle assessment for an eco-friendly management of the production of stabilized microorganismsLife Cycle Management 2015, Aug 2015, Bordeaux, France |
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Using Raman spectroscopy to understand the osmotic stress response of lactic acid bacteriaXXI. Journées du Groupe Français de Spectroscopies Vibrationnelles (GFSV), Jun 2015, Reims, France |
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Challenges underlying the in situ analysis of single bacterial cells by synchrotron FTIR spectromicroscopyEuropean Conference on the Spectroscopy of Biological Molecules (ECSBM 16), Sep 2015, Bochum, Germany |
Environmentally eco-reasoned design process for functional yeast production and stabilization3. European Congress of Applied Biotechnology (ECAB 3), Sep 2015, Nice, France |
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Dynamic characterization of membrane biophysical properties to better understand bacterial tolerance to osmotic and cold stresses encountered during freezingMicrobial Stress: from molecules to systems, Nov 2015, Sitges, Spain |
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Inter-vial heat transfer heterogeneity during freeze-drying: role of vial geometry and position on the shelf7. International Conference ISL-FD, Jul 2015, Barcelona, Spain |
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Initial measurement of the intracellular glass transition of a mammalian cell type under cryopreservation conditions52nd Annual Meeting of the Society for Crryobiology, Jul 2015, Ostrava, Czech Republic. pp.538, ⟨10.1016/j.cryobiol.2015.10.008⟩ |
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Insights into freeze-drying energy consumptions for an environmentally-reasoned process control (poster)GPE – 4th International Congress on Green Process Engineering, 2014, Seville, Spain. pp.546 |
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Freeze-drying modeling: prediction of spatial distribution of product qualityThe Freeze Drying of Pharmaceuticals and Biologicals Conference, Sep 2014, Garmisch-Partenkirchen, Germany |
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Synchrotron UV fluorescence microscopy for determining membrane fluidity modification of single bacteria with temperaturesEuropean Conference on Spectroscopy of Biological Molecules XV, Aug 2014, Oxford, United Kingdom. pp.203-210, ⟨10.3233/BSI-140062⟩ |
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How to increase freeze-drying recovery of biological products by manipulating the ice crystal morphology45. Annual Conference of the British Association for Crystal Growth, Jul 2014, Leeds, United Kingdom |
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A mutual gas diffusion model improves the prediction of mass transfer in freeze-drying (communication orale)IDS 2014 - 19th International Drying Symposium, Aug 2014, Lyon, France |
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Lyophilisation: impact sur la valeur nutritionnelle des alimentsJournées d'Etude de l'Association Française des Diététiciens et Nutritionnistes, Jun 2014, Marseille, France |
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Controlling ice nucleation: the Pros & the ConsPDA International Conference of Lyophilization and Freeze-drying, Oct 2013, Dusseldorf, Germany |
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Propriétés de la membrane et résistance à la lyophilisation de ferments lactiques : Intérêt de la mesure de fluidité membranaire par cytométrie en flux17. Congrès Annuel de l’Association Française de Cytométrie, Oct 2013, Strasbourg, France |
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Analyse environnementale de procédés bio-industrielsSFGP2013 - XIV. Congrès de la Société Française de Génie des Procédés, Oct 2013, Lyon, France |
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Developing smart control strategies of freeze-drying of lactic acid bacteria5. International Conference on Lyophilization and Freeze Drying, Mar 2012, Bologne, Italy |
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Developing smart control strategies for the freeze-drying of bacteriaEFFoST Annual Meeting, Nov 2012, Montpellier, France |
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Developing smart control strategies for freeze-drying of lactic acid bacteria (communication orale)EFFoST Annual Meeting, 2012, Montpellier, France |
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Developing smart control strategies for the freeze-drying of bacteriaISL-FD: 5th International Conference on Lyophilization and Freeze Drying, 2012, Bologna, Italy |
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Biophysical and chemical responses of Lb. bulgaricus to freezing by infrared microspectroscopy7. Soleil User's Meeting, Jan 2012, Saclay, France |
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Real time optimization of freeze-drying of lactic acid bacteria (communication orale)SDDP2012 - 5th International Symposium on Spray Dried Dairy Products, Jun 2012, Saint-Malo, France |
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Towards a better understanding of the freezing resistance of lactic acid bacteriaInternational Conference on Membrane Domains, Nov 2012, Dijon, France |
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Influence of the membrane phase behaviour and lipid composition on the freezing-resistance of lactic acid bacteriaFaraday Discussion 161: Lipids and Membrane Biophysics, Sep 2012, London, United Kingdom |
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The physical behavior of food protein's supramolecular structure during freeze-dryingICEF 11, International Congress of Engineering and Food, May 2011, Athens, Greece |
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Probing live cellular responses to freezing by infrared spectromicroscopyCellNanoSpec 2011, Sep 2011, Porquerolles, France |
Electronic nose characterization of the quality parameters of freeze-dried bacteria14. International Symposium on Olfaction and Electronic Nose, May 2011, New York, United States. pp.125-126, ⟨10.1063/1.3626330⟩ |
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Freeze-drying of lactic acid bacteria : effect of process variables on cell injury48. Annual Meeting of the Society for Cryobiology, Jul 2011, Corvallis, Oregon, United States. ⟨10.1016/j.cryobiol.2011.09.055⟩ |
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Quality degradation of lactic acid bacteria during the freeze drying process : experimental study and mathematical modellingICEF 11, International Congress of Engineering and Food, May 2011, Athens, Greece |
Cryopreservation of Lactobacillus delbrueckii subsp. bulgaricus: towards a quantitative understanding of the cell biophysical response during freezing47. Annual Meeting of the Society for Cryobiology, Jul 2010, Bristol, United Kingdom. ⟨10.1016/j.cryobiol.2010.10.039⟩ |
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Modeling for risk assessment of quality failures: Application to microorganismsFreeze Drying of Pharmaceuticals and Biologicals Conference, Sep 2010, Garmisch-Partenkirchen, Germany |
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Water in freeze-dried lactic acid bacteria: Friend or FoeEuroFoodWater, Mar 2010, Reims, France |
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Computer modelling to optimise freeze-drying cyclesVisiongain's 2nd Annual Lyophilisation Conference, Sep 2009, London, United Kingdom |
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Lyophilisation of pellets : experimental and modelling studyJournée AFSIA-EFCA, 2009, lyon, France |
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Cryotolerance of lactic acid bacteria is influenced by their passive and active responses to cold stressSociety for General Microbiology (SGM) : Autumn Meeting Edimburgh Conference Centre Heriot-Watt University, Sep 2009, Edinburgh, United Kingdom |
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Stabilization of lactic acid bacteria : relevance of physical properties on formulation and process efficiencyX. Congreso Latinoamericano de Microbiologia et Hygiena de los Alimentos, Oct 2009, Punta del Este, Uruguay |
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Freezing : a critical step for freeze-drying cycle development and product stability2008 ISPE Conference : Lyophilisation: Scientific Issues of the Process and Introduction to a Risk-Based Approach, Dec 2008, Barcelona, Spain |
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Impact of freezing, especially the controlled nucleation, on protein freeze-drying efficiencyInforma Life Sciences. Lyophilization of Pharmaceuticals, 2008, Londres, United Kingdom |
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User-friendly modeling of the freeze-drying processThe Freeze Drying of Pharmaceuticals and Biologicals Conference, 2008, Breckenridge, CO, United States |
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Stabilization of freeze-dried Lb Bulgaricus cells: the freezing kinetics effectAnnual Meeting of the Society for Cryobiology, Jul 2008, Charlotte, North Carolina, United States. ⟨10.1016/j.cryobiol.2008.10.090⟩ |
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Quality by deisgn approach : the particular case of freeze-drying process2008 PDA Conference on Quality by Design, Oct 2008, Frankfurt, Germany |
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Impact of thermal properties on protein formulation and freeze-drying cycle developmentISPE Conference on Manufacturing Excellence 2008. Lyophilization: Meeting the Challenges of a Critical Technology, 2008, Tempa,Fl, United States |
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Vacuum freeze-drying of a bed of food pellets: Experimental study and mathematical modellingICEF 10 - International Congress on Engineering and Food, Apr 2008, Vina del Mar, Chile |
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The glassy state of the freeze-concentrated medium formed during freezing: effects on cryopreservation of Lb. bulgaricus cells44. Anual Meeting of the Society for Cryobiology, Jul 2007, Lake Louise, Alberta, Canada. ⟨10.1016/j.cryobiol.2007.10.106⟩ |
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Impact of thermal properties on formulation and on freeze-drying developmentConférence de l'Institut International du Froid (IIF), Institut International du Froid (IIF). FRA., Nov 2007, Strasbourg, France |
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Controlled nucleation improves the efficiency pharmaceutical proteins lyophilizationJournées AFSIA-EFCE, May 2007, Biarritz, France |
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Stabilisation of lactic acid bacteria: relevance of physical properties on formulation efficiency1. Int. DOM Symposium on Microbial Formulation, 2007, Uppsala, Sweden |
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An interactive tool for freeze-drying cycle optimisation based on product quality criteriaInforma Life Sciences. Lyophilization of Pharmaceuticals, Dec 2007, London, United Kingdom |
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Cryopreservation of lactic acid bacteria: Effect of linear cooling ratesAnnual Meeting of the Society for Cryobiology, Jul 2006, Hamburg, Germany. pp.395-396, ⟨10.1016/j.cryobiol.2006.10.067⟩ |
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Physical and biological stability of freeze-dried polymer-sucrose protein formulations related to water activityAmorph 2006, Jul 2006, Cambridge, United Kingdom |
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Impact of physical properties of bioproducts on formulation and freeze-drying cycle developmentInternational Society for Pharmaceutical Engineering (ISPE). Lyophilization Technologies and Practice Seminar, Sep 2006, Vienna, Austria |
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Integration of glass transition in freeze-drying kinetic modelling to improve protein stability13. World Congress of Food Science and Technology "Food is Life", IUFOST XIIIth Congress, Jul 2006, Nantes, France. ⟨10.1051/IUFoST:20060715⟩ |
Physical properties of frozen and freeze-dried starters : Impact on process conditions and formulation efficiencyMinisymposium on Antifungal lactic acid and propionic acid bacteria, May 2005, Uppsala, Sweden |
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An interactive tool for freeze-drying cycle optimization based on product quality criteriaJournées AFSIA-EFCE, May 2005, Paris, France |
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An effective property for the formulation of a freeze-dried food ingredient: Glass transition or Collapse ?9.International Congress on Engineering and Food (ICEF ), Nov 2004, Montpellier, France |
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Collapse temperature of bacterial suspensions: effect of cell concentrationNational Institute of Biological Standards and Control and the Society of Low Temperature Biology entitled "Current Trends in Cryobiology and Lyophilization", Sep 2003, London, United Kingdom |
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Examining the current status of Process Analytical Technology applied to lyophilization: Instrumentation, kinetics, quality criteria and risks area in the cycleBarnett International’s Annual Conference on Freeze-drying, Jun 2004, Dublin, Ireland |
Resistencia de L. plantarum WCFS1 frente a distintos métodos de secado: análisis de componentes celulares asociados a su degradación mediante microespectroscopía FTIR en suspensiónXVIII Congreso argentino de ciencia y tecnología de alimento, Oct 2023, Buenos Aires, Argentina |
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Modélisation thermodynamique de la croissance microbienneMicrobes 2021 16ème congrès national de la SFM, Sep 2021, Nantes, France |
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Delivering remote food engineering labs in COVID-19 time, season 213th European Congress of Chemical Engineering, Sep 2021, online, Germany. , pp.P 4.1.04, 2021 |
Freeze-drying in atypical vials: how to model heat transfer during sublimation by using 3D mathematical modelling9. International Symposium on Lyophilization and Pharmaceutics ISLFD 2019, Sep 2019, Ghent, Belgium. 2019, 9th International Symposium on Lyophilization and Pharmaceutics ISLFD 2019 |
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Cryopreservation-related stresses in Lactobacillus delbrueckii SUBSP. Bulgaricus: Global and multi-scale study55. Annual Meeting of the Society for Cryobiology, Jul 2018, Madrid, Spain. Elsevier Ltd, Cryobiology, 85 (December 2018), 2018, Cryobiology. ⟨10.1016/j.cryobiol.2018.10.184⟩ |
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Structural study of lipid droplet using synchrotron label-free multimodal imaging4. International Conference on Physics and Biological Systems, Oct 2018, Gif-sur-Yvette, France. , 2018, 4th International Conference on Physics and Biological Systems 2018 |
Preserving bacteria with oligosaccharides and eco-friendly processes (Premium)55. Annual Meeting of the Society for Cryobiology, Jul 2018, Madrid, Spain. Elsevier Ltd, Cryobiology, 85, pp.172-173, 2018, Cryobiology. ⟨10.1016/j.cryobiol.2018.10.203⟩ |
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The challenges for freeze-drying complex biological systems: State of the art and future8. International Conference of Lyophilization and Freeze-Drying, Apr 2017, La Havana, Cuba. 2017 |
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Synchrotron label free multimodal imaging to explore lipid droplets in living cellsConférence Jacques Monod Analyses moléculaires de l’organisation et du remodelage des membranes, Apr 2017, Roscoff, France. , 2017 |
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Preservation of Preservation of a smear surface-ripened cheese ecosystem by freezing and freeze-drying: a proof of concepta smear surface-ripened cheese ecosystem by freezing and freeze-drying: a proof of concept7. Congress of European Microbiologists FEMS 2017, Jul 2017, Valencia, Spain. 2017, FEMS 2017 ABSTRACT BOOK |
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Freeze-drying of bacteria: From the understanding of the mechanisms of cell resistance to the sustainable process development and optimization21. Colloque du Club de Bactéries Lactiques, Jun 2017, Lille, France. 2017 |
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Impact of three lateral root types identified in pearl millet on water uptakeInterdrought V, Feb 2017, Hyderabad, India. 2017 |
Mapping membrane fluidity by fluorescence anisotropy to better understand bacterial toloerance to osmotic and cold stresses encountered during freezing52. Annual Meeting of the Society for Cryobiology, Jul 2015, Ostrava, Czech Republic. Elsevier Ltd, 71, pp.549, 2015, Cryobiology. ⟨10.1016/j.cryobiol.2015.10.052⟩ |
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Freeze-drying of bacteria : state of the art and new perspectives7. International Conference of Lyophilization and Freeze-Drying, Jul 2015, Barcelona, Spain. 2015 |
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Towards a better understanding of cryotolerance mechanisms in bacteria52. Annual Meeting of the Society for Cryobiology, Jul 2015, Ostrava, Czech Republic. Academic Press - Elsevier, Cryobiology, 71 (3), pp.548, 2015, Cryobiology |
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Strategies for improving freeze-drying resistance of bacteria: Modulating membrane properties during fermentation52. Annual Meeting of the Society for Cryobiology, Jul 2015, Ostrava, Czech Republic. Academic Press - Elsevier, Cryobiology, 71 (3), pp.550, 2015, Cryobiology |
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Towards the in situ study of bacterial single cells following freeze-drying using synchrotron radiation6. International Conference of Lyophilization and Freeze-Drying, Oct 2013, Sao Paulo, Brazil. 2013 |
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Towards the measurement of membrane fluidity at subzero temperatures for improving cell cryopreservationEuropean Conference on the Spectroscopy of Biological Molecules (ECSBM 15), Aug 2013, Oxford, United Kingdom. Biomedical Spectroscopy and Imaging, 3(3), 2013, Biomedical Spectroscopy and Imaging |
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An evaluation of the advantages and disadvantages of controlling ice nucleation in the lyophilisation processSMi Inaugural Meeting on Lyophilisation: Freeze-Drying in Pharmaceuticals and Biopharmaceutical, Feb 2013, London, United Kingdom. 2013 |
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Cell membrane fluidity : its significance for freezing resistance of lactic acid bacteria49. Annual Meeting of the Society for Cryobiology, Jun 2012, Rosario, Argentina. Cryobiology, 2012, Cryobiology |
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Using synchroton infrared microspectroscopy to better understand the freezing-resistance of lactic acid bacteria49. Annual Meeting of the Society for Cryobiology, Jun 2012, Rosario, Argentina. Elsevier Ltd, Cryobiology, 65 (3), 2012, Cryobiology. ⟨10.1016/j.cryobiol.2012.07.029⟩ |
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The physical behaviour of food protein’s supramolecular structures during freezedrying11. International Congress on Engineering and Food, May 2011, Athènes, Greece. Petros S. Taoukis;Nikolaos G. Stoforos;Vaios T. Karathanos;George D. Saravacos Cosmosware, Ag. Ioannou 53, Athens, Greece, 0030 2106013922 cosmosware@ath.forthnet.gr, 2011, FOOD PROCESS ENGINEERING IN A CHANGING WORLD Proceedings of the 11 th International Congress on Engineering and Food (ICEF11) 3 volumes |
Effect of primary drying above Tg' on the long term stability of freeze-dried proteinsAmorph 2006, Jul 2006, Cambridge, United Kingdom. 2006 |
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Freeze-Drying of Lactic Acid Bacteria: A Stepwise Approach for Developing a Freeze-Drying Protocol Based on Physical PropertiesWillem F. Wolkers; Harriëtte Oldenhof. Cryopreservation and Freeze-Drying Protocols, 2180, Springer US, pp.703-719, 2021, Methods in Molecular Biology, 978-1-0716-0782-4. ⟨10.1007/978-1-0716-0783-1_38⟩ |
Scale-up of freeze-drying cycles, the use of process analytical technology (PAT), and statistical analysisLyophilization of Pharmaceuticals and Biologicals, Editions Springer, 2019, Methods in Pharmacology and Toxicology, 978-1-4939-8927-0. ⟨10.1007/978-1-4939-8928-7_10⟩ |
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Freeze-drying of lactic acid bacteriaCryopreservation and Freeze-Drying Protocols, 1257, Humana Press Inc., 12 p., 2015, Methods in Molecular Biology, 978-1-4939-2192-8. ⟨10.1007/978-1-4939-2193-5_24⟩ |
Compositions pour la lyophilisation de protéinesN° de brevet: 2005 |
Vers la compréhension de la résistance à la congélation de bactéries lactiques grâce à la microspectroscopie infrarouge haute résolution2012, pp.64-65 |
Experimental report of proposal 20121064 : multimodal single cell studies of Yarrowia lipolytica yeast under dehydration and thermal stresses[Technical Report] auto-saisine. 2014 |
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Real time control of the final quality of freeze-dried lactic acid starters[Research Report] INRA. 2013, pp.22 |
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European project CAFE WP3: Process experiments - Deliverable 3.3: Test of optimal control strategies[Research Report] inria. 2013 |
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European project CAFE WP4: Model reduction, validation and simulation - Deliverable 4.2: Portable and documented simulation software for each demonstration process[Contract] . 2013 |
Impact du couple "formation et conduite du procédé" sur la qualité des protéines pharmaceutiques lyophiliséesIngénierie des aliments. Institut National Agronomique Paris Grignon, 2005. Français. ⟨NNT : ⟩ |
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Comprendre les déterminants de résistance des micro-organismes aux procédés de stabilisation pour concevoir des itinéraires technologiques durablesGénie des procédés. Université de Technologie de Compiègne (UTC), Compiegne, FRA., 2019 |