Pascal MARTIN CNRS researcher, team leader of Institut Curie.

Identifiants chercheurs

IdHAL :

stereocilium

ORCID :

0000-0001-6860-4677

IdRef :

123006961

ResearcherID :

A-2847-2013

Présentation

ACADEMIC CURRICULUM:

1989 to 1993: undergraduate studies in both Physics and Chemistry at the Ecole Supérieure de Physique et Chimie Industrielle de la ville de Paris (ESPCI Paris, France).

1993: Master degree in soft-matter physics.

1993-1994: &quot;scientifique du contingent&quot; (military service). Laboratoire Physico-Chimie Curie (PCC), Institut Curie, Paris, France.

1994-1997: PhD in Physics from Université Pierre et Marie Curie (UPMC, now called Sorbonne Université, Paris, France). Dewetting of thin liquid films squeezed between a rigid plate and an elastomer. The PhD was funded by the Michelin tyre company and performed under the supervision of Prof Françoise Brochard-Wyart (PCC, Institut Curie, Paris).

1997-2000: postdoc under the supervision of Prof Jim Hudspeth (Laboratory of Sensory Neuroscience, the Rockefeller University, New York, USA). Active mechanical properties of hair cells, the sensor and amplifiers of the inner ear.

2000-present: CNRS researcher and principal inverstigator. Hair-cell biophysics and acto-myosin molecular systems (PCC, Institut Curie, Paris, France).

RESEARCH SUMMARY: Pascal Martin has developed micromechanical tools to study the active (tension, spontaneous oscillations) and passive (stiffness, friction) mechanical properties of the hair bundle--the mechanosensory antenna of the hair cells in the vertebrate inner ear. In close collaboration with theorists, he has combined experiments and physical models to study the various regimes of active hair-bundle motility as well as the effects of intrinsic noise, friction, and elastic coupling on hair-bundle mechanosensitivity. In parallel, he has developed minimal molecular systems comprising purified myosin molecular motors and actin filaments, demonstrating that spontaneous mechanical oscillations and wave-like beating can emerge from from dynamic instabilities in motor-filament systems. A similar biomimetic approach was also developed to study active transport and positioning of colloidal particles by molecular motors in antiparallel filament networks .

Publications

Article dans une revue (36)

The Critical Thing about the Ear's Sensory Hair Cells A.J. Hudspeth,Pascal Martin Journal of Neuroscience, 2024, 44 (44), pp.e1583242024. ⟨10.1523/JNEUROSCI.1583-24.2024⟩ Article dans une revue hal-05387704v1
Evolving critical oscillators for hearing A.J. Hudspeth,Pascal Martin Nature Reviews Physics, 2023, 6 (4), pp.210-211. ⟨10.1038/s42254-023-00672-2⟩ Article dans une revue hal-04337195v1
Flagella-like beating of actin bundles driven by self-organized myosin waves Marie Pochitaloff,Martin Miranda,Mathieu Richard,Atitheb Chaiyasitdhi,Yasuharu Takagiet al. Nature Physics, 2022, 18 (10), pp.1240. ⟨10.1038/s41567-022-01688-8⟩ Article dans une revue hal-03748988v1
Mechanical Frequency Tuning by Sensory Hair Cells, the Receptors and Amplifiers of the Inner Ear Pascal Martin,A.J. Hudspeth Annual Review of Condensed Matter Physics, 2021, 12 (1), ⟨10.1146/annurev-conmatphys-061020-053041⟩ Article dans une revue hal-03036747v1
Quantifying entropy production in active fluctuations of the hair-cell bundle from time irreversibility and uncertainty relations Édgar Roldán,Jérémie Barral,Pascal Martin,Juan Parrondo,Frank Jülicher New Journal of Physics, 2021, 23 (8), pp.083013. ⟨10.1088/1367-2630/ac0f18⟩ Article dans une revue hal-03427220v2
Fast recovery of disrupted tip links induced by mechanical displacement of hair bundles R. G Alonso,M. Tobin,Pascal Martin,A. J Hudspeth Proceedings of the National Academy of Sciences of the United States of America, 2020, 117 (48), pp.30722-30727. ⟨10.1073/pnas.2016858117⟩ Article dans une revue hal-03076231v1
Stiffness and tension gradients of the hair cell's tip-link complex in the mammalian cochlea Mélanie Tobin,Atitheb Chaiyasitdhi,Vincent Michel,Nicolas Michalski,Pascal Martin eLife, 2019, 8, pp.e43473. ⟨10.7554/eLife.43473⟩ Article dans une revue pasteur-02874559v1
Active cargo positioning in antiparallel transport networks Mathieu Richard,Carles Blanch-Mercader,Hajer Ennomani,Wenxiang Cao,Enrique de La Cruzet al. Proceedings of the National Academy of Sciences of the United States of America, 2019, 116 (30), pp.14835-14842. ⟨10.1073/pnas.1900416116⟩ Article dans une revue hal-02185109v1
Friction from Transduction Channels’ Gating Affects Spontaneous Hair-Bundle Oscillations Jérémie Barral,Frank Julicher,Pascal Martin Biophysical Journal, 2018, 114 (2), pp.425-436. ⟨10.1016/j.bpj.2017.11.019⟩ Article dans une revue hal-01730607v1
Transduction channels' gating can control friction on vibrating hair-cell bundles in the ear Volker Bormuth,Jeremie Barral,J.-F. Joanny,Frank Juelicher,Pascal Martin Proc Natl Acad Sci U S A, 2014, 111 (20), pp.7185-7190. ⟨10.1073/pnas.1402556111⟩ Article dans une revue hal-03299978v1
Fluctuation-Response Theorem for the Active Noisy Oscillator of the Hair-Cell Bundle L. Dinis,Pascal Martin,J. Barral,J. Prost,J.-F. Joanny Physical Review Letters, 2012, 109 (16), pp.160602. ⟨10.1103/PhysRevLett.109.160602⟩ Article dans une revue hal-03299974v1
Phantom tones and suppressive masking by active nonlinear oscillation of the hair-cell bundle Jérémie Barral,Pascal Martin Proceedings of the National Academy of Sciences of the United States of America, 2012, 109 (21), ⟨10.1073/pnas.1202426109⟩ Article dans une revue hal-03771351v1
The physical basis of active mechanosensitivity by the hair-cell bundle Jérémie Barral,Pascal Martin Current Opinion in Otolaryngology & Head and Neck Surgery, 2011, 19 (5), pp.369-375. ⟨10.1097/MOO.0b013e32834a8c33⟩ Article dans une revue hal-03771387v1
A Critique of the Critical Cochlea: Hopf—a Bifurcation—Is Better Than None A. Hudspeth,Frank Jülicher,Pascal Martin Journal of Neurophysiology, 2010, 104 (3), pp.1219-1229. ⟨10.1152/jn.00437.2010⟩ Article dans une revue hal-03771390v1
The remarkable cochlear amplifier J. Ashmore,P. Avan,W.E. Brownell,P. Dallos,K. Dierkeset al. Hearing Research, 2010, 266 (1-2), pp.1-17. ⟨10.1016/j.heares.2010.05.001⟩ Article dans une revue hal-03771392v1
Coupling a sensory hair-cell bundle to cyber clones enhances nonlinear amplification Jérémie Barral,Kai Dierkes,Benjamin Lindner,Frank Jülicher,Pascal Martin Proceedings of the National Academy of Sciences of the United States of America, 2010, 107 (18), pp.8079-8084. ⟨10.1073/pnas.0913657107⟩ Article dans une revue hal-03771397v1
Coordination and collective properties of molecular motors: theory Thomas Guérin,J. Prost,Pascal Martin,Jean-François Joanny Current Opinion in Cell Biology, 2010, 22 (1), pp.14-20. ⟨10.1016/j.ceb.2009.12.012⟩ Article dans une revue istex hal-01659698v1
Spontaneous Oscillations of a Minimal Actomyosin System Under Elastic Loading Pierre-Yves Placais,Martial Balland,Thomas Guérin,Jean-François Joanny,Pascal Martin Physical Review Letters, 2010, 103 (15), pp.158102. ⟨10.1103/PhysRevLett.103.158102⟩ Article dans une revue hal-01659711v1
Harmonin-b, an actin-binding scaffold protein, is involved in the adaptation of mechanoelectrical transduction by sensory hair cells Nicolas Michalski,Vincent Michel,Elisa Caberlotto,Gaëlle Lefèvre,Alexander van Akenet al. Pflügers Archiv European Journal of Physiology, 2009, 459 (1), pp.115-130. ⟨10.1007/s00424-009-0711-x⟩ Article dans une revue pasteur-02616476v1
Spontaneous movements and linear response of a noisy oscillator F. Jülicher,K. Dierkes,B. Lindner,J. Prost,Pascal Martin European Physical Journal E: Soft matter and biological physics, 2009, 29 (4), pp.449-460. ⟨10.1140/epje/i2009-10487-5⟩ Article dans une revue hal-03771628v1
Two-state approach to stochastic hair bundle dynamics Diana Clausznitzer,Benjamin Lindner,Frank Jülicher,Pascal Martin Physical Review E : Statistical, Nonlinear, and Soft Matter Physics [2001-2015], 2008, 77 (4), pp.041901. ⟨10.1103/PhysRevE.77.041901⟩ Article dans une revue hal-03771490v1
Unifying the Various Incarnations of Active Hair-Bundle Motility by the Vertebrate Hair Cell Jean-Yves Tinevez,Frank Julicher,Pascal Martin Biophysical Journal, 2007, 93 (11), pp.4053-4067. ⟨10.1529/biophysj.107.108498⟩ Article dans une revue hal-02616477v1
Molecular Characterization of the Ankle-Link Complex in Cochlear Hair Cells and Its Role in the Hair Bundle Functioning N. Michalski,V. Michel,A. Bahloul,G. Lefevre,J. Barralet al. Journal of Neuroscience, 2007, 27 (24), pp.6478-6488. ⟨10.1523/JNEUROSCI.0342-07.2007⟩ Article dans une revue hal-03771502v1
Active hair-bundle motility harnesses noise to operate near an optimum of mechanosensitivity Björn Nadrowski,Pascal Martin,Frank Jülicher Proceedings of the National Academy of Sciences of the United States of America, 2004, 101 (33), pp.12195-12200. ⟨10.1073/pnas.0403020101⟩ Article dans une revue hal-03771507v1
Spontaneous Oscillation by Hair Bundles of the Bullfrog's Sacculus Pascal Martin,D. Bozovic,Y. Choe,A. Hudspeth Journal of Neuroscience, 2003, 23 (11), pp.4533-4548. ⟨10.1523/JNEUROSCI.23-11-04533.2003⟩ Article dans une revue hal-03771618v1
Comparison of a hair bundle's spontaneous oscillations with its response to mechanical stimulation reveals the underlying active process Pascal Martin,A. Hudspeth,F. Jülicher Proceedings of the National Academy of Sciences of the United States of America, 2001, 98 (25), pp.14380-14385. ⟨10.1073/pnas.251530598⟩ Article dans une revue hal-03771606v1
Adhesion of soft objects on wet substrates Françoise Brochard-Wyart,Axel Buguin,Pascal Martin,Arnaud Martin,Olivier Sandre Journal of Physics: Condensed Matter, 2000, 12 (8A), pp.A239-A244. ⟨10.1088/0953-8984/12/8A/330⟩ Article dans une revue hal-02168817v1
Negative hair-bundle stiffness betrays a mechanism for mechanical amplification by the hair cell Pascal Martin,A. Mehta,A. Hudspeth Proceedings of the National Academy of Sciences of the United States of America, 2000, 97 (22), pp.12026-12031. ⟨10.1073/pnas.210389497⟩ Article dans une revue hal-03771516v1
Putting ion channels to work: Mechanoelectrical transduction, adaptation, and amplification by hair cells A. Hudspeth,Y. Choe,A. Mehta,Pascal Martin Proceedings of the National Academy of Sciences of the United States of America, 2000, 97 (22), pp.11765-11772. ⟨10.1073/pnas.97.22.11765⟩ Article dans une revue hal-03771513v1
Active hair-bundle movements can amplify a hair cell’s response to oscillatory mechanical stimuli Pascal Martin,A. Hudspeth Proceedings of the National Academy of Sciences of the United States of America, 1999, 96 (25), pp.14306-14311. ⟨10.1073/pnas.96.25.14306⟩ Article dans une revue hal-03771533v1
Dewetting at Soft Interfaces Pascal Martin,Françoise Brochard-Wyart Physical Review Letters, 1998, 80 (15), pp.3296-3299. ⟨10.1103/PhysRevLett.80.3296⟩ Article dans une revue hal-03771546v1
Dewetting of Supported Viscoelastic Polymer Films: Birth of Rims F. Brochard-Wyart,G. Debregeas,R. Fondecave,Pascal Martin Macromolecules, 1997, 30 (4), pp.1211-1213. ⟨10.1021/MA960929X⟩ Article dans une revue istex hal-03771566v1
Sessile Droplets at a Solid/Elastomer Interface Pascal Martin,P. Silberzan,F. Brochard-Wyart Langmuir, 1997, 13 (18), pp.4910-4914. ⟨10.1021/la9703151⟩ Article dans une revue istex hal-03771555v1
Viscous Bursting of Suspended Films G. Debrégeas,Pascal Martin,F. Brochard-Wyart Physical Review Letters, 1995, 75 (21), pp.3886-3889. ⟨10.1103/PhysRevLett.75.3886⟩ Article dans une revue hal-03771593v1
Bursting of a Liquid Film on a Liquid Substrate Pascal Martin,A Buguin,F Brochard-Wyart EPL - Europhysics Letters, 1994, 28 (6), pp.421-426. ⟨10.1209/0295-5075/28/6/008⟩ Article dans une revue istex hal-03771577v1
Liquid/liquid dewetting Francoise Brochard Wyart,Pascal Martin,Claude Redon Langmuir, 1993, 9 (12), pp.3682-3690. ⟨10.1021/la00036a053⟩ Article dans une revue istex hal-03771585v1

Communication dans un congrès (3)

Nonlinear Tuning from Coupled Critical Oscillators in a Travelling-Wave Model of The Cochlea Henri Ver Hulst,Carles Blanch-Mercader,Pascal Martin Mechanics of Hearing Workshop 2024, Jun 2024, Ann Harbor - Michigan, United States. ⟨10.5281/zenodo.13342228⟩ Communication dans un congrès hal-04799635v1
The transepithelial potential can control gating compliance of the hair-cell bundle A. Joliot,P. Martin NONLINEARITY AND HEARING: ADVANCES IN THEORY AND EXPERIMENT: Proceedings of the 14th International Mechanics of Hearing Workshop, Jul 2022, Helsingør, Denmark. pp.050006, ⟨10.1063/5.0189296⟩ Communication dans un congrès hal-05387871v1
The Endolymphatic Potential Can Control the Gating Force of the Hair Cell's Transduction Channels Achille Joliot,Pascal Martin Mechanics of Hearing Workshop 2024, Jun 2024, Ann Harbor - Michigan, United States. ⟨10.5281/zenodo.13336409⟩ Communication dans un congrès hal-04797671v1

Chapitre d'ouvrage (1)

Auditory processing by the cochlea Pascal Martin,Geoffrey A. Manley Eric R. Kandel; Steven A. Siegelbaum; Sarah H. Mack; John Koester,. Principles of neural science, McGraw-Hill Education / Medical; 6th edition, pp.594-624, 2021, 978-1-259-64223-4 Chapitre d'ouvrage hal-04037337v1

Pré-publication, Document de travail (2)

Electrical control of the transduction channels’ gating force in mechanosensory hair cells Achille Joliot,Laure Stickel,Pascal Martin 2025 Pré-publication, Document de travail hal-05387733v1
Arrow of Time in Active Fluctuations Édgar Roldán,Jérémie Barral,Pascal Martin,Juan M.R. Parrondo,Frank Jülicher 2020 Pré-publication, Document de travail hal-03077924v1

HDR (1)

Active mechanosensitivity of hair cells from the inner ear and of assemblies of molecular motors in vitro Pascal Martin Physics [physics]. Université Pierre et Marie Curie (Paris 6), 2010 HDR tel-04037295v1