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Sylvie BOUVIER

University Associate Professor, Haematology, University of Montpellier, France Hospital Practitioner, Laboratory of Haematology, University Hospital, Nîmes, France
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Presentation

**Sylvie BOUVIER, age 40 (France) ** PharmD., Ph.D., University Associate Professor, Haematology, University of Montpellier, France Hospital Practitioner, Laboratory of Haematology, University Hospital, Nîmes, France Research Unit “ Institut Desbrest of Epidemiology and Santé Publique INSERM, University of Montpellier, France *Haemostasis, Thrombosis, Thrombophilia, Netosis, Venous thromboembolism, Vascular Biology, Pregnancy-related vascular complications.* Full professional adress: Consultations et Laboratoire d’Hématologie, Centre Hospitalier Universitaire, Groupe Hospitalo-Universitaire Caremeau, Place du Pr. Robert debré, F-30029 Nîmes cedex 9, France Phone number: +33 466 683 211 Fax number: +33 466 683 648 Email: sylvie.bouvier@chu-nimes.fr; sylvie.bouvier@umontpellier.fr **EDUCATION AND TRAINING ** - 2010: PharmD., Faculty of Pharmaceutical and Biological Science, University of Montpellier. - 2010: Diploma of Specialized Studies (DES), Medical Biology, University of Montpellier. - 2011: Master 2 graduate degree, academic area "Biology and Health", University of Montpellier. - 2014: Ph.D. degree, academic area "Biology and Health", University of Montpellier. - 2021: HDR “Habilitation à Diriger des Recherches”, University of Montpellier. **PROFESSIONAL EXPERIENCE** 2006-2010: Resident in Medical Biology, Montpellier University, Nîmes and Montpellier. 2010-2013: University Hospital Assistant (AHU), Haematology, Faculty of Pharmaceutical and Biological Science, University of Montpellier and Laboratory of Haematology, University Hospital, Nîmes. 2013-2014: Post-Doctoral degree, INSERM UMR-S1076, Vascular Research Center of Marseille (VRCM). Faculty of Pharmaceutical and Biological Science, Aix Marseille University. 2014-2015: Associate practitioner in Haematology, Laboratory of Haematology, University Hospital, Nîmes. 2015-present: University Associate Professor, Haematology, University of Montpellier and Hospital Practitioner (MCU-PH), Laboratory of Haematology, University Hospital, Nîmes. 2022-present: Co-coordinator of the Diploma of Specialized Studies (DES) in Medical Biology, University of Montpellier. **RESEARCH TOPICS:** Haemostasis, Thrombosis, Venous thromboembolism, Vascular Biology, Netosis, Pregnancy-related vascular complications. **GRANTS** Internal grants obtained from the University Hospital of Nîmes (NIMAO internal grant) : 258.6 k€ Grants obtained from the University Hospital of Nîmes and the University Hospital of Montpellier (GCS Meri) : 74.8 k€ **ACTIVITY OF COLLECTIVE INTEREST** Member of the Scientific Council on Clinical Research, University Hospital, Nîmes. Member of the “Conseil National des Universités” Section 82 (CNU 82). Member of the Association of Teachers of Haematology, Immunology and Biotherapy (AssHIB). Member of the International Society on Thrombosis and Haemostasis ISTH, of the French Society of Haematology SFH, of the French Society on Thrombosis and Haemostasis, SFTH, of the French National Association of Molecular Genetics Practitioners, ANPGM. **10 MAIN PUBLICATIONS** Guillotin F, Fortier M, Portes M, Demattei C, Cultrera L, Loyens M, Mousty E, Nouvellon E, Mercier E, Bourguignon C, Chea M, Letouzey V, Gris JC,** **Bouvier S****. Direct blood fluorescence signal intensity of neutrophils (NEU-SFL): A marker of NETosis in preeclampsia? Thromb Res. 2023 ;221:65-68. doi: 10.1016/j.thromres.2022.11.022. Guillotin F, Fortier M, Portes M, Demattei C, Mousty E, Nouvellon E, Mercier E, Chea M, Letouzey V, Gris JC, **Bouvier S.** Vital NETosis vs. suicidal NETosis during normal pregnancy and preeclampsia. Front Cell Dev Biol. 2023 ;10:1099038. doi: 10.3389/fcell.2022.1099038. Fortier M, Chea M, Aïn C, Loyens M, Boudemaghe T, Gris JC, **Bouvier S**. Direct blood fluorescence signal intensity of neutrophils (NEU-SFL): A predictive marker of death in hospitalized COVID-19 patients? Front Med (Lausanne). 2022:1;9:1062112. doi: 10.3389/fmed.2022.1062112. **Bouvier S**, Fortier M, Vincent L, Demattei C, Mousty E, Herzog M, Rommelaere G, Nouvellon E, Mercier E, Letouzey V, Gris JC. NETosis Markers in Pregnancy: Effects Differ According to Histone Subtypes. Thromb Haemost. 2021; 121(7):877-890. **Bouvier S**, Kaspi E, Joshkon A, Paulmyer-Lacroix O, Piercecchi-Marti MD, Sharma A, Leroyer AS, Bertaud A, Gris JC, Dignat-George F, Blot-Chabaud M, Bardin N. The Role of the Adhesion Receptor CD146 and Its Soluble Form in Human Embryo Implantation and Pregnancy. Front Immunol. 2021;12:711394. doi: 10.3389/fimmu.2021.711394. **Bouvier S,** Mousty E, Fortier M, Demattei C, Mercier E, Nouvellon E, Chea M, Grosjean F, Letouzey V, Gris JC. Placenta-mediated complications: Nucleosomes and free DNA concentrations differ depending on subtypes. J Thromb Haemost. 2020;18(12):3371-3380. **Bouvier S**, Paulmyer-Lacroix O, Molinari N, Bertaud A, Paci M, Leroyer A, Dignat George F, Blot-Chabaud M, Bardin N. Soluble CD146, an innovative and non-invasive biomarker of embryo selection for in vitro fertilization. Plos One 2017;12(3):e0173724. **Bouvier S**, Cochery-Nouvellon E, Lavigne-Lissalde G, Mercier E, Marchetti T, Balducchi JP, Marès P, Gris JC. Comparative incidence of pregnancy outcomes in treated obstetric antiphospholipid syndrome: the NOH-APS observational study. Blood 2014; 123(3):404-413. **Bouvier S**, Cochery-Nouvellon E, Lavigne-Lissalde G, Mercier E, Fabbro-Peray P, Balducchi JP, Marès P, Gris JC. Comparative incidence of pregnancy outcomes in thrombophilia-positive women from the NOH-APS observational study. Blood 2014; 123(3):414-421. Gris JC, **Bouvier S**, Molinari N, Galanaud JP, Cochery-Nouvellon E, Mercier E, Fabbro-Peray P, Balducchi JP, Marès P, Quéré I, Dauzat M. Comparative incidence of a first thrombotic event in purely obstetric antiphospholipid syndrome with pregnancy loss: the NOH-APS observational study. Blood. 2012 Mar 15;119(11):2624-32. doi: 10.1182/blood-2011-09-381913.

Skills

Haemostasis Thrombosis Thrombophilia Netosis Venous thromboembolism Vascular Biology Pregnancy-related vascular complications

Publications

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Vital NETosis vs. suicidal NETosis during normal pregnancy and preeclampsia

Florence Guillotin , Mathieu Fortier , Marie Portes , Christophe Demattei , Eve Mousty
Frontiers in Cell and Developmental Biology, 2023, 10, pp.1099038. ⟨10.3389/fcell.2022.1099038⟩
Journal articles hal-03948661v1

Direct blood fluorescence signal intensity of neutrophils (NEU-SFL): A marker of NETosis in preeclampsia?

Florence Guillotin , Mathieu Fortier , Marie Portes , Christophe Demattei , Léa Cultrera
Thrombosis Research, 2023, 221, pp.65-68. ⟨10.1016/j.thromres.2022.11.022⟩
Journal articles hal-03949076v1
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The Risk of Thrombosis Around Pregnancy: Where Do We Stand?

Jean-Christophe Gris , Florence Guillotin , Mathias Chéa , Chloé Bourguignon , Sylvie Bouvier
Frontiers in Cardiovascular Medicine, 2022, 9, pp.901869. ⟨10.3389/fcvm.2022.901869⟩
Journal articles hal-03701543v1
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Direct blood fluorescence signal intensity of neutrophils (NEU-SFL): A predictive marker of death in hospitalized COVID-19 patients?

Mathieu Fortier , Mathias Chéa , Charlène Aïn , Maxime Loyens , Thierry Boudemaghe
Frontiers in Medicine, 2022, 9, pp.7. ⟨10.3389/fmed.2022.1062112⟩
Journal articles hal-03948922v1
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PREGNANCY AFTER COMBINED ORAL CONTRACEPTIVE-ASSOCIATED VENOUS THROMBOEMBOLISM: AN INTERNATIONAL RETROSPECTIVE STUDY OF OUTCOMES

Jean Christophe Gris , Chloé Bourguignon , Sylvie Bouvier , eva nouvellon , Jeremy Laurent
Thrombosis and Haemostasis, 2022, ⟨10.1055/a-1835-8808⟩
Journal articles hal-03701565v1

Reference values of coagulation assays performed for thrombophilia screening after a first venous thrombosis and their intra-patient associations

Jean-Christophe Gris , Éva Cochery-Nouvellon , Chloé Bourguignon , Éric Mercier , Sylvie Bouvier
Thrombosis Research, 2022, 210, pp.94-103. ⟨10.1016/j.thromres.2022.01.005⟩
Journal articles hal-03662714v1

Combined oral contraceptive-associated venous thromboembolism revealing an antiphospholipid syndrome: International retrospective study of outcomes

Jean-Christophe Gris , Chloé Bourguignon , Sylvie Bouvier , Éva Nouvellon , Jeremy Laurent
Thrombosis Research, 2022, 219, pp.102-108. ⟨10.1016/j.thromres.2022.09.013⟩
Journal articles hal-04058804v1
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Soluble CD146 is increased in preeclampsia and interacts with galectin-1 to regulate trophoblast migration through VEGFR2 receptor

Sylvie Bouvier , Waël Traboulsi , Sandra M Blois , Christophe Demattei , Ahmad Joshkon
F&S Science, 2022, 3 (1), pp.84-94. ⟨10.1016/j.xfss.2021.11.002⟩
Journal articles hal-03701653v1

NETosis Markers in Pregnancy: Effects Differ According to Histone Subtypes

Sylvie Bouvier , Mathieu Fortier , Laura Vincent , Christophe Demattei , Eve Mousty
Thrombosis and Haemostasis, 2021, 121 (07), pp.877-890. ⟨10.1055/s-0040-1722225⟩
Journal articles hal-04394117v1

NETosis Markers in Pregnancy: Effects Differ According to Histone Subtypes

Sylvie Bouvier , Mathieu Fortier , Laura Vincent , Christophe Demattei , Eve Mousty
Thrombosis and Haemostasis, 2021, 121 (07), pp.877-890. ⟨10.1055/s-0040-1722225⟩
Journal articles hal-03622210v1
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Early ADAMTS13 testing associates with pre-eclampsia occurrence in antiphospholipid syndrome

Viktoria Bitsadze , Sylvie Bouvier , Jamilya Khizroeva , Eva Nouvellon , Eric Mercier
Thrombosis Research, 2021, 203, pp.101-109. ⟨10.1016/j.thromres.2021.04.021⟩
Journal articles hal-03634541v1
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The Role of the Adhesion Receptor CD146 and Its Soluble Form in Human Embryo Implantation and Pregnancy

Sylvie Bouvier , Elise Kaspi , Ahmad Joshkon , Odile Paulmyer-Lacroix , Marie-Dominique Piercecchi-Marti
Frontiers in Immunology, 2021, 12, pp.711394. ⟨10.3389/fimmu.2021.711394⟩
Journal articles hal-03504344v1
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Discovery of Type 3 von Willebrand Disease in a Cohort of Patients with Suspected Hemophilia A in Côte d'Ivoire

Adia Eusèbe Adjambri , Sylvie Bouvier , Roseline N'Guessan , Emma N’draman-Donou , Mireille Yayo-Ayé
Mediterranean Journal of Hematology and Infectious Diseases, 2020, 12 (1), pp.e2020019. ⟨10.4084/MJHID.2020.019⟩
Journal articles hal-03349450v1

Increased incidence of cancer in the follow-up of obstetric antiphospholipid syndrome within the NOH-APS cohort

Jean-Christophe Gris , Éve Mousty , Sylvie Bouvier , Sylvie Ripart , Éva Cochery-Nouvellon
Haematologica, 2020, 105 (2), pp.490-497. ⟨10.3324/haematol.2018.213991⟩
Journal articles hal-03353790v1

The association between D‐dimers in COVID‐19 patients and mortality remains beset of uncertainties

Jean-Christophe Gris , Paul Loubet , Claire Roger , Eva Cochery‐nouvellon , Jean‐marc Mauboussin
Journal of Thrombosis and Haemostasis, 2020, ⟨10.1111/jth.14941⟩
Journal articles hal-02890756v1

Placenta‐mediated complications: Nucleosomes and free DNA concentrations differ depending on subtypes

Sylvie Bouvier , Eve Mousty , Mathieu Fortier , Christophe Demattei , Eric Mercier
Journal of Thrombosis and Haemostasis, 2020, 18 (12), pp.3371-3380. ⟨10.1111/jth.15105⟩
Journal articles hal-03337256v1
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The role of haemostasis in placenta-mediated complications

Jean-Christophe Gris , Sylvie Bouvier , Eva Cochery-Nouvellon , Eric Mercier , Eve Mousty
Thrombosis Research, 2019, 181 (Suppl. 1), pp.S10-S14. ⟨10.1016/S0049-3848(19)30359-7⟩
Journal articles hal-02859858v1

Clinical value of automated fibrin generation markers in patients with septic shock: a SepsiCoag ancillary study

Jean‐christophe Gris , Eva Cochery-Nouvellon , Sylvie Bouvier , Samir Jaber , Jacques Albanese
British Journal of Haematology, 2018, 183 (4), pp.636-647. ⟨10.1111/bjh.15576⟩
Journal articles hal-04394203v1

Successful Pregnancy under Fibrinogen Substitution with Heparin and Aspirin in a Woman with Dysfibrinogenemia Revealed by Placental Abruption

Sylvie Bouvier , Mathias Chea , Sylvie Ripart , Michel Hanss , Philippe De Mazancourt
Thrombosis and Haemostasis, 2018, 118 (11), pp.2006--2008. ⟨10.1055/s-0038-1673615⟩
Journal articles hal-02359786v1

Reliability of hemostasis biomarkers is affected by time-dependent intra-patient variability

Sylvie Bouvier , S. Bastide , S. Chouirfa , É Nouvellon , É Mercier
Journal of Thrombosis and Haemostasis, 2018, ⟨10.1111/jth.14198⟩
Journal articles hal-02361111v1
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Clinical value of automated fibrin generation markers in patients with septic shock: a SepsiCoag ancillary study

Jean-Christophe Gris , Eva Cochery-Nouvellon , Sylvie Bouvier , Samir Jaber , Jacques Albanese
British Journal of Haematology, 2018, pp.636-647. ⟨10.1111/bjh.15576⟩
Journal articles hal-01872785v1

Antiphospholipid antibodies are associated with positive screening for common mental disorders in women with previous pregnancy loss. The NOHA-PSY observational study

Jean-Christophe Gris , Fabienne Cyprien , Sylvie Bouvier , Eva Cochery-Nouvellon , Géraldine Lavigne-Lissalde
World Journal of Biological Psychiatry, 2017, pp.1--13. ⟨10.1080/15622975.2017.1333146⟩
Journal articles hal-01819348v1
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Soluble CD146, an innovative and non-invasive biomarker of embryo selection for in vitro fertilization

Sylvie Bouvier , Odile Paulmyer-Lacroix , Nicolas Molinari , Alexandrine Bertaud , Marine Paci
PLoS ONE, 2017, 12 (3), ⟨10.1371/journal.pone.0173724⟩
Journal articles hal-01821370v1

Atypical monoblasts with micronuclei

Sylvie Bouvier , Mélanie Martin
Blood, 2017, 130 (17), pp.1958. ⟨10.1182/blood-2017-07-795542⟩
Journal articles hal-01891557v1

Obstetric antiphospholipid syndrome: early variations of angiogenic factors are associated with adverse outcomes

Eva Cochery-Nouvellon , Erick Mercier , Sylvie Bouvier , Jean-Pierre Balducchi , Isabelle Quere
Haematologica, 2017, 102 (5), pp.835 - 842. ⟨10.3324/haematol.2016.155184⟩
Journal articles hal-01897475v1

Atypical monoblasts with micronuclei

Sylvie Bouvier , Mélanie Martin
Blood, 2017, 130 (17), pp.1958-1958. ⟨10.1182/blood-2017-07-795542⟩
Journal articles hal-04394278v1

Antiphospholid antibodies and the risk of pregnancy complications

Jean-Christophe Gris , Sylvie Bouvier , Eva Nouvellon , Géraldine Lissalde-Lavigne , Erick Mercier
Thrombosis Research, 2017, 151 (Suppl.1), pp.S34 - S37. ⟨10.1016/S0049-3848(17)30064-6⟩
Journal articles hal-01896583v1

Neuropsychiatric presentations of antiphospholipid antibodies

Jean-Christophe Gris , Benédicte Nobile , Sylvie Bouvier
Thrombosis Research, 2015, 135 (Suppl.1), pp.S56 - S59. ⟨10.1016/S0049-3848(15)50445-3⟩
Journal articles hal-01916578v1

Comparative incidence of pregnancy outcomes in thrombophilia-positive women from the NOH-APS observational study

Sylvie Bouvier , Eva Cochery-Nouvellon , Géraldine Lavigne-Lissalde , Eric Mercier , Pascale Fabbro-Peray
Blood, 2014, 123 (3), pp.414-421. ⟨10.1182/blood-2013-09-525014⟩
Journal articles hal-01942335v1

Comparative incidence of pregnancy outcomes in treated obstetric antiphospholipid syndrome: the NOH-APS observational study

Sylvie Bouvier , Eva Cochery-Nouvellon , Géraldine Lavigne-Lissalde , Eric Mercier , Tess Marchetti
Blood, 2014, 123 (3), pp.404-413. ⟨10.1182/blood-2013-08-522623⟩
Journal articles hal-01942537v1

Polymorphisms of Human Placental Alkaline Phosphatase Are Associated with in Vitro Fertilization Success and Recurrent Pregnancy Loss

Magalie Vatin , Sylvie Bouvier , Linda Bellazi , Xavier Montagutelli , Paul Laissue
American Journal of Pathology, 2014, 184 (2), pp.362-368. ⟨10.1016/j.ajpath.2013.10.024⟩
Journal articles hal-01943648v1