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Thibaut Douché



**2003:** Brevet de Technicien Supérieur - Biochimiste (Académie de Lille) **2008:** MASTER - Biochimie Structurale, Protéomique et Métabolomique (Académie de Toulouse) **2008/2009:** Institut de Pharmacologie et de Biologie Structurale CNRS/UMR5089 (Toulouse) - Laboratoire de Protéomique et Spectrométrie de Masse des Biomolécules. **2009/2012:** Laboratoire de Recherche en Sciences Végétales CNRS/UMR5546 (Castanet-Tolosan) - Equipe Protéines Pariétales et Développement. **2011/2015:** Centre de Recherche en Cancérologie de Toulouse INSERM/U1037 (Toulouse) - Equipe Signalisation PI3K et Contrôle Traductionnel dans les Tumeurs Pancréatiques et Hypophysaires. **2015-2021:** Institut Pasteur (Paris) - Unité de Technologie et de Service Spectrométrie de Masse pour la Biologie (UTechS MSBio)


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RNase E and HupB dynamics foster mycobacterial cell homeostasis and fitness

Anna Griego , Thibaut Douché , Quentin Giai Gianetto , Mariette Matondo , Giulia Manina et al.
iScience, 2022, 25 (5), pp.104233. ⟨10.1016/j.isci.2022.104233⟩
Journal articles pasteur-03693876v1
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Ser/Thr Kinase-Dependent Phosphorylation of the Peptidoglycan Hydrolase CwlA Controls Its Export and Modulates Cell Division in Clostridioides difficile

Transito Garcia-Garcia , Sandrine Poncet , Elodie Cuenot , Thibaut Douché , Quentin Giai Gianetto et al.
mBio, 2021, 12 (3), pp.e00519-21. ⟨10.1128/mBio.00519-21⟩
Journal articles pasteur-03243540v1
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CYP450 core involvement in multiple resistance strains of Aedes aegypti from French Guiana highlighted by proteomics, molecular and biochemical studies

Yanouk Epelboin , Lanjiao Wang , Quentin Giai Gianetto , Valérie Choumet , Pascal Gaborit et al.
PLoS ONE, 2021, 16 (1), pp.e0243992. ⟨10.1371/journal.pone.0243992⟩
Journal articles pasteur-03184205v1
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RNase R is associated in a functional complex with the RhpA DEAD-box RNA helicase in Helicobacter pylori

Alejandro Tejada Arranz , Rute G Matos , Yves Quentin , Maxime Bouilloux-Lafont , Eloïse Galtier et al.
Nucleic Acids Research, 2021, 49 (9), pp.5249-5264. ⟨10.1093/nar/gkab283⟩
Journal articles pasteur-03242387v1
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Cell wall proteomic datasets of stems and leaves of Brachypodium distachyon

Thibaut Douché , Benoît Valot , Thierry Balliau , Hélène San Clemente , Michel Zivy et al.
Data in Brief, 2021, 35, pp.1-4. ⟨10.1016/j.dib.2021.106818⟩
Journal articles hal-03259235v1
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Pharmacologic Normalization of Pancreatic Cancer-Associated Fibroblast Secretome Impairs Prometastatic Cross-Talk With Macrophages

Rémi Samain , Alexia Brunel , Thibaut Douché , Marjorie Fanjul , Stéphanie Cassant-Sourdy et al.
Cellular and Molecular Gastroenterology and Hepatology, 2021, 11 (5), pp.1405-1436. ⟨10.1016/j.jcmgh.2021.01.008⟩
Journal articles pasteur-03252986v1
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Quality standards in proteomics research facilities

Cristina Chiva , Teresa Mendes Maia , Christian Panse , Karel Stejskal , Thibaut Douché et al.
EMBO Reports, 2021, 22 (6), pp.e52626. ⟨10.15252/embr.202152626⟩
Journal articles pasteur-03258884v1
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Proteomic Analysis Uncovers Measles Virus Protein C Interaction With p65–iASPP Protein Complex

Alice Meignié , Chantal Combredet , Marc Santolini , István Kovács , Thibaut Douché et al.
Molecular and Cellular Proteomics, 2021, 20, pp.100049. ⟨10.1016/j.mcpro.2021.100049⟩
Journal articles pasteur-03184181v1

Disorder-To-Order Transitions and Post-Translational Acylation Control the Folding and Activity of the Bordetella Pertussis CyaA Toxin

Darragh P. O'Brien , Alexis Voegele , Dorothee Raoux-Barbot , Marilyne Davi , Sara Cannella et al.
Biophysical Journal, 2020, 118 (3), pp.197A--197A
Journal articles hal-02516165v1
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The Flemmingsome reveals an ESCRT-to-membrane coupling via ALIX/syntenin/syndecan-4 required for completion of cytokinesis

Cyril Addi , Adrien Presle , Stéphane Frémont , Frédérique Cuvelier , Murielle Rocancourt et al.
Nature Communications, 2020, 11 (1), pp.1941. ⟨10.1038/s41467-020-15205-z⟩
Journal articles pasteur-02557366v1

Post-translational acylation controls the folding and functions of the CyaA RTX toxin

Darragh O'Brien , Sara E Cannella , Alexis Voegele , Dorothée Raoux-Barbot , Marilyne Davi et al.
FASEB Journal, 2019, 33 (9), pp.10065-10076. ⟨10.1096/fj.201802442RR⟩
Journal articles pasteur-02330713v1
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The Ser/Thr kinase PrkC participates in cell wall homeostasis and antimicrobial resistance in Clostridium difficile

Elodie Cuenot , Transito Garcia-Garcia , Thibaut Douche , Olivier Gorgette , Pascal Courtin et al.
Infection and Immunity, 2019, 87 (8), pp.e00005-19. ⟨10.1128/IAI.00005-19⟩
Journal articles pasteur-02164685v1

CotL, a new morphogenetic spore coat protein of Clostridium difficile

Carolina Alves Feliciano , Thibaut Douche , Quentin Giai Gianetto , Mariette I Matondo , Isabelle Martin-Verstraete et al.
Environmental Microbiology, 2019, 21 (3), pp.984-1003. ⟨10.1111/1462-2920.14505⟩
Journal articles pasteur-02331056v1
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The Adenylate Cyclase (CyaA) Toxin from Bordetella pertussis Has No Detectable Phospholipase A (PLA) Activity In Vitro

Alexis Voegele , Mirko Sadi , Dorothée Raoux-Barbot , Thibaut Douche , Mariette Matondo et al.
Toxins, 2019, Special Issue RTX Toxins, 11 (2), pp.111. ⟨10.3390/toxins11020111⟩
Journal articles pasteur-02329482v1
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Signal-Targeted Therapies and Resistance Mechanisms in Pancreatic Cancer: Future Developments Reside in Proteomics

Celia Cintas , Thibaut Douche , Nicole Therville , Silvia Arcucci , Fernanda Ramos-Delgado et al.
Cancers, 2018, 10 (6), pp.174. ⟨10.3390/cancers10060174⟩
Journal articles hal-02500132v1
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Proteome remodelling by the stress sigma factor RpoS/σS in Salmonella: identification of small proteins and evidence for post-transcriptional regulation

Magali Lago , Véronique Monteil , Thibaut Douche , Julien Guglielmini , Alexis Criscuolo et al.
Scientific Reports, 2017, 7, pp.2127. ⟨10.1038/s41598-017-02362-3⟩
Journal articles pasteur-01540240v1
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Characterization of Post-Translational Modifications and Cytotoxic Properties of the Adenylate-Cyclase Hemolysin Produced by Various Bordetella pertussis and Bordetella parapertussis Isolates

Valerie Bouchez , Thibaut Douche , Mélody Dazas , Sophie Delaplane , Mariette Matondo et al.
Toxins, 2017, 9 (10), pp.304. ⟨10.3390/toxins9100304⟩
Journal articles pasteur-02573143v1
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Cell wall proteome of sugarcane stems: comparison of a destructive and a non-destructive extraction method showed differences in glycoside hydrolases and peroxidases

Maria Juliana Calderan-Rodrigues , Elisabeth Jamet , Thibaut Douché , Maria Beatriz Rodrigues Bonassi , Thaís Regiani Cataldi et al.
BMC Plant Biology, 2016, 16 (1), pp.14. ⟨10.1186/s12870-015-0677-0⟩
Journal articles hal-03259237v1

Brachypodium distachyon as a model plant toward improved biofuel crops: search for secreted proteins involved in biogenesis and disassembly of cell wall polymers

Thibaut Douche , Hélène San Clemente , Vincent Burlat , David Roujol , Benoit B. Valot et al.
Proteomics, 2013, 13 (16), pp.2438-2454. ⟨10.1002/pmic.201200507⟩
Journal articles hal-02647765v1

Diagnostic value and prognostic significance of plasmatic proteasome level in patients with melanoma

Laurent Henry , Thierry Lavabre-Bertrand , Thibaut Douche , Sandrine Uttenweiler-Joseph , Pascale Fabbro-Peray et al.
Experimental Dermatology, 2010, 19 (12), pp.1054-1059. ⟨10.1111/j.1600-0625.2010.01151.x⟩
Journal articles hal-02503539v1