Thibaut Douché

Présentation

2003: Brevet de Technicien Supérieur - Biochimiste (Académie de Lille)

2008: MASTER - Biochimie Structurale, Protéomique et Métabolomique (Académie de Toulouse)

2008/2009: Institut de Pharmacologie et de Biologie Structurale CNRS/UMR5089 (Toulouse) - Laboratoire de Protéomique et Spectrométrie de Masse des Biomolécules.

2009/2012: Laboratoire de Recherche en Sciences Végétales CNRS/UMR5546 (Castanet-Tolosan) - Equipe Protéines Pariétales et Développement.

2011/2015: Centre de Recherche en Cancérologie de Toulouse INSERM/U1037 (Toulouse) - Equipe Signalisation PI3K et Contrôle Traductionnel dans les Tumeurs Pancréatiques et Hypophysaires.

2015-2021: Institut Pasteur (Paris) - Unité de Technologie et de Service Spectrométrie de Masse pour la Biologie (UTechS MSBio)

Publications

Article dans une revue (29)

Biogenesis of DNA-carrying extracellular vesicles by the dominant human gut methanogenic archaeon Diana P Baquero,Guillaume Borrel,Anastasia Gazi,Camille Martin-Gallausiaux,Virginija Cvirkaite-Krupovicet al. Nature Communications, 2025, 16 (1), pp.5093. ⟨10.1038/s41467-025-60272-9⟩ Article dans une revue pasteur-05097185v1
A Multiyear Longitudinal Harmonization Study of Quality Controls in Mass Spectrometry Proteomics Core Facilities Cristina Chiva,Roger Olivella,An Staes,Teresa Mendes Maia,Christian Panseet al. Journal of Proteome Research, 2025, 24 (2), pp.397-409. ⟨10.1021/acs.jproteome.4c00359⟩ Article dans une revue pasteur-05076146v1
In-host evolution of Yersinia enterocolitica during a chronic human infection Cyril Savin,Pierre Lê-Bury,Julien Guglielmini,Thibaut Douché,Guillem Mas Fiolet al. Nature Communications, 2025, 16 (1), pp.5637. ⟨10.1038/s41467-025-60782-6⟩ Article dans une revue pasteur-05138169v2
Influenza A virus induces PI4P production at the endoplasmic reticulum in an ATG16L1-dependent manner to promote the egress of viral ribonucleoproteins Carla Alemany,Juliane da Graça,Quentin Giai Gianetto,Maud Dupont,Sylvain Paisantet al. PLoS Biology, 2025, 23 (7), pp.e3002958. ⟨10.1371/journal.pbio.3002958⟩ Article dans une revue pasteur-05381127v1
The extent of postpartum cardiac reverse remodeling is reflected in urine proteome Ana F Ferreira,Fábio Trindade,Maria J Azevedo,Juliana Morais,Thibaut Douchéet al. Scientific Reports, 2024, 14 (1), pp.14815. ⟨10.1038/s41598-024-65612-1⟩ Article dans une revue pasteur-05076147v1
Profiling Cullin4-E3 Ligases Interactomes and Their Rewiring in Influenza A Virus Infection Guillaume Dugied,Thibaut Douche,Melanie dos Santos,Quentin Giai Gianetto,Camille Cassonnetet al. Molecular and Cellular Proteomics, 2024, 23 (11), pp.100856. ⟨10.1016/j.mcpro.2024.100856⟩ Article dans une revue pasteur-04854515v1
Acetylation regulates the oligomerization state and activity of RNase J, the Helicobacter pylori major ribonuclease Alejandro Tejada-Arranz,Aleksei Lulla,Maxime Bouilloux-Lafont,Evelyne Turlin,Xue-Yuan Peiet al. Nature Communications, 2023, 14 (1), pp.8072. ⟨10.1038/s41467-023-43825-8⟩ Article dans une revue hal-04612500v1
Amphiregulin mediates non-cell-autonomous effect of senescence on reprogramming Mathieu von Joest,Cheng Chen,Thibaut Douché,Jérémy Chantrel,Aurélie Chicheet al. Cell Reports, 2022, 40 (2), pp.111074. ⟨10.1016/j.celrep.2022.111074⟩ Article dans une revue pasteur-04093575v1
RNase E and HupB dynamics foster mycobacterial cell homeostasis and fitness Anna Griego,Thibaut Douché,Quentin Giai Gianetto,Mariette Matondo,Giulia Manina iScience, 2022, 25 (5), pp.104233. ⟨10.1016/j.isci.2022.104233⟩ Article dans une revue pasteur-03693876v1
Ser/Thr Kinase-Dependent Phosphorylation of the Peptidoglycan Hydrolase CwlA Controls Its Export and Modulates Cell Division in Clostridioides difficile Transito Garcia-Garcia,Sandrine Poncet,Elodie Cuenot,Thibaut Douché,Quentin Giai Gianettoet al. mBio, 2021, 12 (3), pp.e00519-21. ⟨10.1128/mBio.00519-21⟩ Article dans une revue pasteur-03243540v1
CYP450 core involvement in multiple resistance strains of Aedes aegypti from French Guiana highlighted by proteomics, molecular and biochemical studies Yanouk Epelboin,Lanjiao Wang,Quentin Giai Gianetto,Valérie Choumet,Pascal Gaboritet al. PLoS ONE, 2021, 16 (1), pp.e0243992. ⟨10.1371/journal.pone.0243992⟩ Article dans une revue pasteur-03184205v1
Quality standards in proteomics research facilities Cristina Chiva,Teresa Mendes Maia,Christian Panse,Karel Stejskal,Thibaut Douchéet al. EMBO Reports, 2021, 22 (6), pp.e52626. ⟨10.15252/embr.202152626⟩ Article dans une revue pasteur-03258884v1
Proteomic Analysis Uncovers Measles Virus Protein C Interaction With p65–iASPP Protein Complex Alice Meignié,Chantal Combredet,Marc Santolini,István Kovács,Thibaut Douchéet al. Molecular and Cellular Proteomics, 2021, 20, pp.100049. ⟨10.1016/j.mcpro.2021.100049⟩ Article dans une revue pasteur-03184181v1
RNase R is associated in a functional complex with the RhpA DEAD-box RNA helicase in Helicobacter pylori Alejandro Tejada Arranz,Rute G Matos,Yves Quentin,Maxime Bouilloux-Lafont,Eloïse Galtieret al. Nucleic Acids Research, 2021, 49 (9), pp.5249-5264. ⟨10.1093/nar/gkab283⟩ Article dans une revue pasteur-03242387v1
Phosphoproteomics identifies PI3K inhibitor-selective adaptive responses in pancreatic cancer cell therapy and resistance C Cintas,T Douche,Z Dantes,Emmanuelle Mouton-Barbosa,Marie-Pierre Bousquetet al. Molecular Cancer Therapeutics, 2021, 20 (12), pp.2433-2445. ⟨10.1158/1535-7163.MCT-20-0981⟩ Article dans une revue hal-03223423v1
Pharmacologic Normalization of Pancreatic Cancer-Associated Fibroblast Secretome Impairs Prometastatic Cross-Talk With Macrophages Rémi Samain,Alexia Brunel,Thibaut Douché,Marjorie Fanjul,Stéphanie Cassant-Sourdyet al. Cellular and Molecular Gastroenterology and Hepatology, 2021, 11 (5), pp.1405-1436. ⟨10.1016/j.jcmgh.2021.01.008⟩ Article dans une revue hal-03252986v1
Cell wall proteomic datasets of stems and leaves of Brachypodium distachyon Thibaut Douché,Benoît Valot,Thierry Balliau,Hélène San Clemente,Michel Zivyet al. Data in Brief, 2021, 35, pp.1-4. ⟨10.1016/j.dib.2021.106818⟩ Article dans une revue (data paper) hal-03259235v1
The Flemmingsome reveals an ESCRT-to-membrane coupling via ALIX/syntenin/syndecan-4 required for completion of cytokinesis Cyril Addi,Adrien Presle,Stéphane Frémont,Frédérique Cuvelier,Murielle Rocancourtet al. Nature Communications, 2020, 11 (1), pp.1941. ⟨10.1038/s41467-020-15205-z⟩ Article dans une revue pasteur-02557366v1
Disorder-To-Order Transitions and Post-Translational Acylation Control the Folding and Activity of the Bordetella Pertussis CyaA Toxin Darragh P. O'Brien,Alexis Voegele,Dorothee Raoux-Barbot,Marilyne Davi,Sara Cannellaet al. Biophysical Journal, 2020, 118 (3), pp.197A--197A. ⟨10.1016/j.bpj.2019.11.1189⟩ Article dans une revue hal-02516165v1
The Adenylate Cyclase (CyaA) Toxin from Bordetella pertussis Has No Detectable Phospholipase A (PLA) Activity In Vitro Alexis Voegele,Mirko Sadi,Dorothée Raoux-Barbot,Thibaut Douche,Mariette Matondoet al. Toxins, 2019, Special Issue RTX Toxins, 11 (2), pp.111. ⟨10.3390/toxins11020111⟩ Article dans une revue pasteur-02329482v1
Post-translational acylation controls the folding and functions of the CyaA RTX toxin Darragh O'Brien,Sara E Cannella,Alexis Voegele,Dorothée Raoux-Barbot,Marilyne Daviet al. FASEB Journal, 2019, 33 (9), pp.10065-10076. ⟨10.1096/fj.201802442RR⟩ Article dans une revue pasteur-02330713v1
The Ser/Thr kinase PrkC participates in cell wall homeostasis and antimicrobial resistance in Clostridium difficile Elodie Cuenot,Transito Garcia-Garcia,Thibaut Douche,Olivier Gorgette,Pascal Courtinet al. Infection and Immunity, 2019, 87 (8), pp.e00005-19. ⟨10.1128/IAI.00005-19⟩ Article dans une revue pasteur-02164685v1
CotL, a new morphogenetic spore coat protein of Clostridium difficile Carolina Alves Feliciano,Thibaut Douche,Quentin Giai Gianetto,Mariette I Matondo,Isabelle Martin-Verstraeteet al. Environmental Microbiology, 2019, 21 (3), pp.984-1003. ⟨10.1111/1462-2920.14505⟩ Article dans une revue pasteur-02331056v1
Signal-Targeted Therapies and Resistance Mechanisms in Pancreatic Cancer: Future Developments Reside in Proteomics Celia Cintas,Thibaut Douche,Nicole Therville,Silvia Arcucci,Fernanda Ramos-Delgadoet al. Cancers, 2018, 10 (6), pp.174. ⟨10.3390/cancers10060174⟩ Article dans une revue hal-02500132v1
Proteome remodelling by the stress sigma factor RpoS/σS in Salmonella: identification of small proteins and evidence for post-transcriptional regulation Magali Lago,Véronique Monteil,Thibaut Douche,Julien Guglielmini,Alexis Criscuoloet al. Scientific Reports, 2017, 7, pp.2127. ⟨10.1038/s41598-017-02362-3⟩ Article dans une revue pasteur-01540240v1
Characterization of Post-Translational Modifications and Cytotoxic Properties of the Adenylate-Cyclase Hemolysin Produced by Various Bordetella pertussis and Bordetella parapertussis Isolates Valerie Bouchez,Thibaut Douche,Mélody Dazas,Sophie Delaplane,Mariette Matondoet al. Toxins, 2017, 9 (10), pp.304. ⟨10.3390/toxins9100304⟩ Article dans une revue pasteur-02573143v1
Cell wall proteome of sugarcane stems: comparison of a destructive and a non-destructive extraction method showed differences in glycoside hydrolases and peroxidases Maria Juliana Calderan-Rodrigues,Elisabeth Jamet,Thibaut Douché,Maria Beatriz Rodrigues Bonassi,Thaís Regiani Cataldiet al. BMC Plant Biology, 2016, 16 (1), pp.14. ⟨10.1186/s12870-015-0677-0⟩ Article dans une revue hal-03259237v1
&lt;em&gt;Brachypodium distachyon&lt;/em&gt; as a model plant toward improved biofuel crops: search for secreted proteins involved in biogenesis and disassembly of cell wall polymers Thibaut Douche,Hélène San Clemente,Vincent Burlat,David Roujol,Benoit B. Valotet al. Proteomics, 2013, 13 (16), pp.2438-2454. ⟨10.1002/pmic.201200507⟩ Article dans une revue istex hal-02647765v1
Diagnostic value and prognostic significance of plasmatic proteasome level in patients with melanoma Laurent Henry,Thierry Lavabre-Bertrand,Thibaut Douche,Sandrine Uttenweiler-Joseph,Pascale Fabbro-Perayet al. Experimental Dermatology, 2010, 19 (12), pp.1054-1059. ⟨10.1111/j.1600-0625.2010.01151.x⟩ Article dans une revue istex hal-02503539v1

Chapitre d'ouvrage (1)

Applying Reverse Genetics to Study Measles Virus Interactions with the Host Heidy Vera-Peralta,Valérie Najburg,Chantal Combredet,Thibaut Douché,Quentin Giai Gianettoet al. Dzwokai Z. Ma; Christian K. Pfaller. Measles and Related Morbilliviruses: Methods and Protocols, 2808, Springer, pp.89-103, 2024, Methods in Molecular Biology, 978-1-0716-3870-5 (eBook). ⟨10.1007/978-1-0716-3870-5_7⟩ Chapitre d'ouvrage hal-04638406v1

Pré-publication, Document de travail (4)

Influenza A virus-induced PI4P production at the endoplasmic reticulum involves ATG16L1 and promotes the egress of viral ribonucleoproteins Carla Alemany,Juliane Da Graça,Quentin Giai-Gianetto,Sylvain Paisant,Maud Dupontet al. 2024 Pré-publication, Document de travail hal-05132641v1
Dual proteomic signature of immune cells and Yersinia pestis upon blood infection Pierre Lê-Bury,Thibaut Douché,Quentin Giai Gianetto,Mariette Matondo,Javier Pizarro-Cerdáet al. 2024 Pré-publication, Document de travail pasteur-04585310v1
Post-transcriptional regulation of Leishmania fitness gain Laura Piel,K. Shanmugha Rajan,Giovanni Bussotti,Hugo Varet,Rachel Legendreet al. 2021 Pré-publication, Document de travail pasteur-03210825v1
Post-translational acylation controls the folding and functions of the CyaA RTX toxin Darragh P O'Brien,Sara E Cannella,Alexis Voegele,Dorothée Raoux-Barbot,Maryline Daviet al. 2021 Pré-publication, Document de travail pasteur-03221015v1