Thierry Billard

Publications

Article dans une revue (95)

Direct Fluoroformylation of the C3 ‐Position of Indoles with 2,4‐Dinitro(trifluoromethoxy)benzene as Fluorocarbonyl Source Lilian Wisson,Gilles Hanquet,Fabien Toulgoat,Thierry Billard,Frédéric R Lerouxet al. ChemistryOpen, 2026, 15 (3), pp.e202500563. ⟨10.1002/open.202500563⟩ Article dans une revue hal-05549792v1
Synthetic Route to Fluoroalkylselenylchalcogeno Molecules Clément Delobel,Oz Barnier,Fabien Toulgoat,Thierry Billard European Journal of Organic Chemistry, 2025, 28 (37), pp.e202500561. ⟨10.1002/ejoc.202500561⟩ Article dans une revue hal-05368366v1
Intertwined Processes in the Pummerer‐Type Rearrangement Affording α‐Trifluoromethoxylated Thioethers and the Corresponding Highly Enantioenriched Sulfoxides Nicolas Moget,Jérémy Saiter,Fabien Toulgoat,Thierry Billard,Frédéric R. Lerouxet al. Chemistry - A European Journal, 2025, 31 (72), pp.e02465. ⟨10.1002/chem.202502465⟩ Article dans une revue hal-05549752v1
CF&lt;sub&gt;3&lt;/sub&gt;S-N bond formation under mild conditions. Easy access to trifluoromethanesulfenamides with a versatile reagent Clément Delobel,Fabien Toulgoat,Thierry Billard Journal of Fluorine Chemistry, 2024, 279, pp.110353. ⟨10.1016/j.jfluchem.2024.110353⟩ Article dans une revue hal-04729048v1
Perspectives on obesity imaging: [18F]2FNQ1P a specific 5-HT6 brain PET radiotracer Pierre Courault,Sandrine Bouvard,Caroline Bouillot,Radu Bolbos,Waël Zeinyehet al. International Journal of Obesity, 2024, ⟨10.1038/s41366-024-01644-x⟩ Article dans une revue hal-04793046v1
Trifluoromethoxylation of Arynes using 2,4‐Dinitro‐1‐(trifluoromethoxybenzene) as Trifluoromethoxide Anion Source Lilian Wisson,Gilles Hanquet,Fabien Toulgoat,Thierry Billard,Armen Panossianet al. European Journal of Organic Chemistry, In press, 27 (28), pp.e202400388. ⟨10.1002/ejoc.202400388⟩ Article dans une revue hal-04591124v1
A journey into trifluoromethylchalcogenation: some reagents from Lyon Thierry Billard Comptes Rendus. Chimie, 2024, 27 (G1), pp.217-226. ⟨10.5802/crchim.341⟩ Article dans une revue hal-04781579v1
WAY-208466, a 5-HT6 receptor agonist, increases food motivation in primates: A behavioural and PET imaging study opening perspectives in eating disorders Mathilde Pitoy,Julie Maulavé,Lisa Gauthier,Justine Debatisse,Nicolas Costeset al. Neuroscience Applied, 2024, 3, pp.104086. ⟨10.1016/j.nsa.2024.104086⟩ Article dans une revue hal-04811333v1
Phenylseleno trifluoromethoxylation of alkenes Clément Delobel,Armen Panossian,Gilles Hanquet,Frédéric R Leroux,Fabien Toulgoatet al. Beilstein Journal of Organic Chemistry, 2024, 20, pp.2434-2441. ⟨10.3762/bjoc.20.207⟩ Article dans une revue hal-04711420v1
Unlocking the Power of Acyl Fluorides: A Comprehensive Guide to Synthesis and Properties Clémence Bonnefoy,Adrien Gallego,Clément Delobel,Betty Raynal,Maxime Decourtet al. European Journal of Organic Chemistry, 2024, 27 (18), pp.e202400142. ⟨10.1002/ejoc.202400142⟩ Article dans une revue hal-04591439v1
Deep Study of Thiocarbamoyl Fluorides: Synthesis and Properties Clément Delobel,Emmanuel Chefdeville,Fabien Toulgoat,Thierry Billard Advanced Synthesis and Catalysis, 2024, 366 (16), pp.3474-3480. ⟨10.1002/adsc.202400412⟩ Article dans une revue hal-04684868v1
Focus on Physico‐Chemical Properties of Sulfoximines: Acidity, Basicity and Lipophilicity Elsa Anselmi,Bénédicte Montigny,Märt Lõkov,Carmen Kesküla,Jan Erik Soosaaret al. Chemistry - A European Journal, 2024, 31 (1), pp.e202402329. ⟨10.1002/chem.202402329⟩ Article dans une revue hal-04814363v1
Difluoromethoxylated Ketones as Building Blocks for the Synthesis of Challenging OCF2H‐Bearing N‐Heterocycles. Anaïs Loison,Gilles Hanquet,Fabien Toulgoat,Thierry Billard,Armen Panossianet al. European Journal of Organic Chemistry, 2023, 26 (42), pp.e202300695. ⟨10.1002/ejoc.202300695⟩ Article dans une revue hal-04163739v2
Perfluoroalkyl Selenoxides, Selenones and Selenoximines: General Preparation and Properties Arnaud de Zordo-Banliat,Kevin Grollier,Nicolas Vanthuyne,Sébastien Floquet,Thierry Billardet al. Angewandte Chemie International Edition, 2023, 62 (12), ⟨10.1002/anie.202300951⟩ Article dans une revue hal-04046563v1
Comprehensive Study and Development of a Metal-Free and Mild Nucleophilic Trifluoromethoxylation Clémence Bonnefoy,Armen Panossian,Gilles Hanquet,Frédéric Leroux,Fabien Toulgoatet al. Chemistry - A European Journal, 2023, 29 (46), ⟨10.1002/chem.202301513⟩ Article dans une revue hal-04165325v1
Vinylic Trifluoromethylselenolation via Pd‐Catalyzed C−H Activation Arnaud de Zordo-Banliat,Kevin Grollier,Jordan Vigier,Erwann Jeanneau,Guillaume Dagoussetet al. Chemistry - A European Journal, In press, ⟨10.1002/chem.202202299⟩ Article dans une revue hal-03784203v1
Electrochemical Trifluoromethylselenolation of Activated Alkyl Halides Kevin Grollier,Clément Ghiazza,Anis Tlili,Thierry Billard,Maurice Médebielleet al. European Journal of Organic Chemistry, 2022, 2022 (19), ⟨10.1002/ejoc.202200123⟩ Article dans une revue hal-03834330v1
Study of Carbamoyl Fluoride: Synthesis, Properties and Applications Clémence Bonnefoy,Emmanuel Chefdeville,Christian Tourvieille,Armen Panossian,Gilles Hanquetet al. Chemistry - A European Journal, 2022, 28 (43), ⟨10.1002/chem.202201589⟩ Article dans une revue hal-03744602v1
Ketenimines as Intermediates To Access Difluoromethoxylated Scaffolds Anaïs Loison,Gilles Hanquet,Fabien Toulgoat,Thierry Billard,Armen Panossianet al. Organic Letters, 2022, ⟨10.1021/acs.orglett.2c03283⟩ Article dans une revue hal-03843401v1
Synthesis, Reactivity and Activation Modes of Fluoroalkyl Thiosulfonates and Selenosulfonates Clément Ghiazza,Thierry Billard European Journal of Organic Chemistry, 2021, 2021 (41), pp.5571-5584. ⟨10.1002/ejoc.202100944⟩ Article dans une revue hal-03834333v1
Different alterations of agonist and antagonist binding to 5-HT1A receptor in a rat model of Parkinson's disease and levodopa-induced dyskinesia : a microPET study Benjamin Vidal,Élise Levigoureux,Sarah Chaib,Caroline Bouillot,Thierry Billardet al. Journal of Parkinson's disease, 2021, 11 (3), pp.1257-1269. ⟨10.3233/JPD-212580⟩ Article dans une revue hal-03407557v1
Recent synthetic methods towards the –OCHF2 moiety Anaïs Loison,Fabien Toulgoat,Thierry Billard,Gilles Hanquet,Armen Panossianet al. Tetrahedron, 2021, 99, pp.132458. ⟨10.1016/j.tet.2021.132458⟩ Article dans une revue hal-03517915v1
[18F]F13640, a 5-HT1A Receptor Radiopharmaceutical Sensitive to Brain Serotonin Fluctuations Matthieu Colom,Benjamin Vidal,Sylvain Fieux,Jérôme Redouté,Nicolas Costeset al. Frontiers in Neuroscience, 2021, 15, pp.622423. ⟨10.3389/fnins.2021.622423⟩ Article dans une revue hal-03407570v1
(Trifluoromethylselenyl)methylchalcogenyl as emerging fluorinated groups: synthesis under photoredox catalysis and determination of the lipophilicity Kevin Grollier,Arnaud de Zordo‐banliat,Flavien Bourdreux,Bruce Pegot,Guillaume Dagoussetet al. Chemistry - A European Journal, 2021, 27 (19), pp.6028-6033. ⟨10.1002/chem.202100053⟩ Article dans une revue hal-03407531v1
Solvent free nucleophilic selenocyanation with [bmim][SeCN]. Direct access to perfluoroalkylselenide compounds Arnaud De-Zordo Banliat,Kévin Grollier,Aurélie Damond,Thierry Billard,Guillaume Dagoussetet al. Tetrahedron, 2021, 101, pp.132507. ⟨10.1016/j.tet.2021.132507⟩ Article dans une revue hal-03834344v1
Aromatic Trifluoromethylselenolation via Pd-catalyzed C-H functionalization Kevin Grollier,Emmanuel Chefdeville,Erwann Jeanneau,Thierry Billard Chemistry - A European Journal, 2021, 27 (50), pp.12910-12916. ⟨10.1002/chem.202102121⟩ Article dans une revue hal-03407550v1
Fe-mediated nucleophilic trifluoromethylselenolation of activated alkyl bromides via umpolung reactivity of trifluoromethyl tolueneselenosulfinate Kevin Grollier,Emmanuel Chefdeville,Arnaud de Zordo-Banliat,Bruce Pegot,Guillaume Dagoussetet al. Tetrahedron, 2021, 100, pp.132498. ⟨10.1016/j.tet.2021.132498⟩ Article dans une revue hal-03834329v1
Study of a Stable “Trifluoromethoxide Anion Solution” Arising from 2,4‐Dinitro‐Trifluoromethoxybenzene Clémence Bonnefoy,Emmanuel Chefdeville,Armen Panossian,Gilles Hanquet,Frédéric R. Lerouxet al. Chemistry - A European Journal, 2021, 27 (64), pp.15986-15991. ⟨10.1002/chem.202102809⟩ Article dans une revue hal-03582991v1
Metal-free nucleophilic trifluoromethylselenolation via an iodide-mediated umpolung reactivity of trifluoromethylselenotoluenesulfonate Kevin Grollier,Alexis Taponard,Arnaud de Zordo-Banliat,Emmanuel Magnier,Thierry Billard Beilstein Journal of Organic Chemistry, 2020, 16, pp.3032 - 3037. ⟨10.3762/bjoc.16.252⟩ Article dans une revue hal-03097741v1
18F-F13640 PET imaging of functional receptors in humans Matthieu Colom,Nicolas Costes,Jérôme Redouté,Frédéric Dailler,Florent Gobertet al. European Journal of Nuclear Medicine and Molecular Imaging, 2020, 47 (1), pp.220-221. ⟨10.1007/s00259-019-04473-7⟩ Article dans une revue hal-02305453v1
Fluoroalkylselenolation of Alkyl Silanes/Trifluoroborates under Metal-Free Visible-Light Photoredox Catalysis Clément Ghiazza,Lhoussain Khrouz,Thierry Billard,Cyrille Monnereau,Anis Tlili European Journal of Organic Chemistry, 2020, 2020 (10), pp.1559-1566. ⟨10.1002/ejoc.201901063⟩ Article dans une revue hal-03008842v1
Synthetic Approaches to Fluoroalkyltelluryl-Substituted Compounds Kévin Grollier,Alexis Taponard,Thierry Billard European Journal of Organic Chemistry, 2020, 2020 (45), pp.6943-6954. ⟨10.1002/ejoc.202000839⟩ Article dans une revue hal-03043875v1
Environmentally Compatible Access to α‐Trifluoromethylseleno‐Enones Kevin Grollier,Alexis Taponard,Clément Ghiazza,Emmanuel Magnier,Thierry Billard Helvetica Chimica Acta, 2020, 103 (11), ⟨10.1002/hlca.202000185⟩ Article dans une revue hal-03033317v1
Change in Expression of 5-HT6 Receptor at Different Stages of Alzheimer’s Disease: A Postmortem Study with the PET Radiopharmaceutical [18F]2FNQ1P Pierre Courault,Stéphane Emery,Sandrine Bouvard,François Liger,Fabien Chauveauet al. Journal of Alzheimer's Disease, 2020, 75 (4), pp.1329-1338. ⟨10.3233/JAD-191278⟩ Article dans une revue hal-03035778v1
Preclinical validation of [18F]2FNQ1P as a specific PET radiotracer of 5-HT6 receptors in rat, pig, non-human primate and human brain tissue Stéphane Emery,Sylvain Fieux,Benjamin Vidal,Pierre Courault,Sandrine Bouvardet al. Nuclear Medicine and Biology, 2020, 82-83, pp.57-63. ⟨10.1016/j.nucmedbio.2020.01.006⟩ Article dans une revue hal-03035781v1
Merging Visible-Light Catalysis for the Direct Late-Stage Group-16-Trifluoromethyl Bond Formation Clément Ghiazza,Thierry Billard,Anis Tlili Chemistry - A European Journal, 2019, 25 (26), pp.6482-6495. ⟨10.1002/chem.201806234⟩ Article dans une revue hal-02107065v1
Visible-Light-Mediated Synthesis of Trifluoromethylthiolated Arenes Clément Ghiazza,Cyrille Monnereau,Lhoussain Khrouz,Thierry Billard,Anis Tlili Synthesis: Journal of Synthetic Organic Chemistry, 2019, 51 (14), pp.2865-2870. ⟨10.1055/s-0037-1610322⟩ Article dans une revue hal-03008849v1
11 C-Labeling: Intracyclic Incorporation of Carbon-11 into Heterocycles François Liger,Florence Cadarossanesaib,Thibaut Iecker,Christian Tourvieille,Didier Le Barset al. European Journal of Organic Chemistry, 2019, 2019 (41), pp.6968-6972. ⟨10.1002/ejoc.201901386⟩ Article dans une revue hal-02382036v1
Evaluation of Myelin Radiotracers in the Lysolecithin Rat Model of Focal Demyelination: Beware of Pitfalls! Min Zhang,Gaëlle Hugon,Caroline Bouillot,Radu Bolbos,Jean-Baptiste Langloiset al. Contrast Media and Molecular Imaging, 2019, Use of Animal Models in Molecular Imaging, 2019, pp.9294586. ⟨10.1155/2019/9294586⟩ Article dans une revue hal-02278818v1
Chalcogen OCF 3 Isosteres Modulate Drug Properties without Introducing Inherent Liabilities Clément Ghiazza,Thierry Billard,Callum Dickson,Anis Tlili,Christian Gampe ChemMedChem, 2019, 14 (17), pp.1586-1589. ⟨10.1002/cmdc.201900452⟩ Article dans une revue hal-03035756v1
Difluoro(aryl)(perfluoroalkyl)‐λ 4 ‐sulfanes and Selanes: Missing Links of Trichloroisocyanuric Acid/Potassium Fluoride Chemistry Fabian Brüning,Cody Ross Pitts,Jorna Kalim,Dustin Bornemann,Clément Ghiazzaet al. Angewandte Chemie International Edition, 2019, 58 (52), pp.18937-18941. ⟨10.1002/anie.201910594⟩ Article dans une revue hal-04409441v1
Evaluation of [18F]2FP3 in pigs and non-human primates Hanne Hansen,Cristian Constantinescu,Olivier Barret,Matthias Herth,Janus Magnussenet al. Journal of Labelled Compounds and Radiopharmaceuticals, 2019, 62 (1), pp.34-42. ⟨10.1002/jlcr.3692⟩ Article dans une revue hal-02109621v1
New Avenues in Radical Trifluoromethylselenylation with ­Trifluoromethyl Tolueneselenosulfonate Clément Ghiazza,Cyrille Monnereau,Lhoussain Khrouz,Maurice Médebielle,Thierry Billardet al. SYNLETT, 2019, 30 (07), pp.777-782. ⟨10.1055/s-0037-1610347⟩ Article dans une revue hal-02106887v1
Umpolung Reactivity of Fluoroalkylselenotoluenesulfonates: Towards a Versatile Reagent Clément Ghiazza,Alex Kataria,Anis Tlili,Fabien Toulgoat,Thierry Billard Asian Journal of Organic Chemistry, 2019, ⟨10.1002/ajoc.201900027⟩ Article dans une revue hal-02106892v1
Fluorous l -Carbidopa Precursors: Highly Enantioselective Synthesis and Computational Prediction of Bioactivity Albert Granados,Anna Del Olmo,Francesca Peccati,Thierry Billard,Mariona Sodupeet al. Journal of Organic Chemistry, 2018, 83 (1), pp.303-313. ⟨10.1021/acs.joc.7b02685⟩ Article dans une revue hal-02382031v1
Regioselective remote C H fluoroalkylselenolation of 8-aminoquinolines Clément Ghiazza,Moussa Ndiaye,Anfal Hamdi,Anis Tlili,Thierry Billard Tetrahedron, 2018, 74 (45), pp.6521-6526. ⟨10.1016/j.tet.2018.09.048⟩ Article dans une revue hal-02109638v1
Visible-Light-Mediated Metal-Free Synthesis of Trifluoromethylselenolated Arenes Clément Ghiazza,Vincent Debrauwer,Cyrille Monnereau,Lhoussain Khrouz,Maurice Médebielleet al. Angewandte Chemie International Edition, 2018, 57 (36), pp.11781 - 11785. ⟨10.1002/anie.201806165⟩ Article dans une revue hal-01889009v1
Nucleophilic trifluoromethylthiolation of organoselenocyanates with trifluoromethanesulfenamide reagent: Access to CF3SSe-containing compounds Quentin Glenadel,Camille Ayad,Marc-Alexandre D’elia,Thierry Billard,Fabien Toulgoat Journal of Fluorine Chemistry, 2018, 210, pp.112-116. ⟨10.1016/j.jfluchem.2018.03.009⟩ Article dans une revue hal-02109639v1
A Metal-Free Route to Heterocyclic Trifluoromethyl- and Fluoroalkylselenolated Molecules Quentin Glenadel,Ermal Ismalaj,Thierry Billard Organic Letters, 2018, 20 (1), pp.56-59. ⟨10.1021/acs.orglett.7b03338⟩ Article dans une revue hal-02382029v1
Amyloid-beta radiotracer [18F]BF-227 does not bind to cytoplasmic glial inclusions of post-mortem Multiple System Atrophy brain tissue Mathieu Verdurand,Élise Levigoureux,Sophie Lancelot,Waël Zeinyeh,Thierry Billardet al. Contrast Media and Molecular Imaging, 2018, 2018, ⟨10.1155/2018/9165458⟩ Article dans une revue hal-01691091v1
In Silico, in Vitro, and in Vivo Evaluation of New Candidates for α-Synuclein PET Imaging Mathieu Verdurand,Élise Levigoureux,Waël Zeinyeh,Laurent Berthier,Meriem Mendjel-Herdaet al. Molecular Pharmaceutics, 2018, 15 (8), pp.3153-3166. ⟨10.1021/acs.molpharmaceut.8b00229⟩ Article dans une revue hal-01955442v1
Direct α-C-H Trifluoromethylselenolation of Carbonyl Compounds Clément Ghiazza,Anis Tlili,Thierry Billard European Journal of Organic Chemistry, 2018, 2018 (27-28), pp.3680-3683. ⟨10.1002/ejoc.201800237⟩ Article dans une revue hal-02109647v1
Visible-light promoted fluoroalkylselenolation: toward the reactivity of unsaturated compounds Clément Ghiazza,Lhoussain Khrouz,Cyrille Monnereau,Thierry Billard,Anis Tlili Chemical Communications, 2018, 54 (71), pp.9909 - 9912. ⟨10.1039/C8CC05256E⟩ Article dans une revue hal-01889019v1
Synthetic Approaches to Trifluoromethylselenolated Compounds Anis Tlili,Ermal Ismalaj,Quentin Glenadel,Clément Ghiazza,Thierry Billard Chemistry - A European Journal, 2018, 24 (15), pp.3659-3670. ⟨10.1002/chem.201704637⟩ Article dans une revue hal-02382034v1
Exploring the Reactivity of Trifluoromethyl Tolueneselenosulfonate with Alkynes under Copper Catalysis Clément Ghiazza,Vincent Debrauwer,Thierry Billard,Anis Tlili Chemistry - A European Journal, 2018, 24 (1), pp.97-100. ⟨10.1002/chem.201705231⟩ Article dans une revue hal-02109631v1
18F-F13640 preclinical evaluation in rodent, cat and primate as a 5-HT1A receptor agonist for PET neuroimaging Benjamin Vidal,Sylvain Fieux,Matthieu Colom,Thierry Billard,Caroline Bouillotet al. Brain Structure and Function, 2018, 223 (6), pp.2973-2988. ⟨10.1007/s00429-018-1672-7⟩ Article dans une revue hal-02107028v1
Trifluoromethyl‐ and Fluoroalkylselenolations of Alkynyl Copper(I) Compounds Clément Ghiazza,Thierry Billard,Anis Tlili Chemistry - A European Journal, 2017, 23 (42), pp.10013-10016. ⟨10.1002/chem.201702028⟩ Article dans une revue hal-04409412v1
Inside Back Cover: Superacid-Catalyzed Trifluoromethylthiolation of Aromatic Amines (Angew. Chem. Int. Ed. 1/2017) Longin Justin Clair Bonazaba milandou,Hélène Carreyre,Sébastien Alazet,Gino Greco,Agnès Martin-Mingotet al. Angewandte Chemie International Edition, 2017, 56 (1), pp.417 - 417. ⟨10.1002/anie.201611312⟩ Article dans une revue hal-01610196v1
[11C]PF-3274167 as a PET radiotracer of oxytocin receptors: Radiosynthesis and evaluation in rat brain Benjamin Vidal,Iuliia Karpenko,François Liger,Sylvain Fieux,Caroline Bouillotet al. Nuclear Medicine and Biology, 2017, 55, pp.1-6. ⟨10.1016/j.nucmedbio.2017.07.008⟩ Article dans une revue hal-01689748v1
Electrophilic trifluoromethylselenolation of terminal alkynes with Se -(trifluoromethyl) 4-methylbenzenesulfonoselenoate Clément Ghiazza,Anis Tlili,Thierry Billard Beilstein Journal of Organic Chemistry, 2017, 13, pp.2626-2630. ⟨10.3762/bjoc.13.260⟩ Article dans une revue hal-04409417v1
Trifluoromethylselenolation and Fluoroalkylselenolation of Alkenes by Electrophilic Addition Clément Ghiazza,Quentin Glenadel,Anis Tlili,Thierry Billard European Journal of Organic Chemistry, 2017, 2017 (26), pp.3812-3814. ⟨10.1002/ejoc.201700643⟩ Article dans une revue hal-04409410v1
Electrophilic Trifluoromethylselenolation of Boronic Acids Clément Ghiazza,Anis Tlili,Thierry Billard Molecules, 2017, Tri- and Di-Fluoromethylation and Tri- and Di-Fluoromethylchalcogenation Reactions, 22 (5), pp.833. ⟨10.3390/molecules22050833⟩ Article dans une revue hal-04409404v1
Generation of the SCF3 radical by photoredox catalysis: Intra- and intermolecular carbotrifluoromethylthiolation of alkenes Guillaume Dagousset,Cédric Simon,Elsa Anselmi,Béatrice Tuccio,Thierry Billardet al. Chemistry - A European Journal, 2017, 23 (18), pp.4282-4286. ⟨10.1002/chem.201700734⟩ Article dans une revue hal-01606062v1
Superacid-Catalyzed Trifluoromethylthiolation of Aromatic Amines Longin Justin Clair Bonazaba milandou,Hélène Carreyre,Sébastien Alazet,Gino Greco,Agnès Martin-Mingotet al. Angewandte Chemie, 2017, 129 (1), pp.175 - 178. ⟨10.1002/ange.201609574⟩ Article dans une revue hal-01598373v1
Characterization and Reliability of [18F]2FNQ1P in Cynomolgus Monkeys as a PET Radiotracer for Serotonin 5-HT6 Receptors Véronique Sgambato-Faure,Thierry Billard,Elise Metereau,Sandra Duperrier,Sylvain Fieuxet al. Frontiers in Pharmacology, 2017, 8, pp.471. ⟨10.3389/fphar.2017.00471⟩ Article dans une revue hal-01689720v1
Innenrücktitelbild: Superacid-Catalyzed Trifluoromethylthiolation of Aromatic Amines (Angew. Chem. 1/2017) Longin Justin Clair Bonazaba milandou,Hélène Carreyre,Sébastien Alazet,Gino Greco,Agnès Martin-Mingotet al. Angewandte Chemie, 2017, 129 (1), pp.429 - 429. ⟨10.1002/ange.201611312⟩ Article dans une revue hal-01610193v1
Copper-catalyzed perfluoroalkylthiolation of alkynes with perfluoroalkanesulfenamides Anis Tlili,Sébastien Alazet,Quentin Glenadel,Thierry Billard Chemistry - A European Journal, 2016, 22 (29), pp.10230-10234. ⟨10.1002/chem.201601338⟩ Article dans une revue istex hal-01484732v1
Metal-free direct nucleophilic perfluoroalkylthiolation with perfluoroalkanesulfenamides Quentin Glenadel,Mathieu Bordy,Sébastien Azalet,Anis Tlili,Thierry Billard Asian Journal of Organic Chemistry, 2016, 5 (3), pp.428-433. ⟨10.1002/ajoc.201600003⟩ Article dans une revue istex hal-01313903v1
Metal-free direct dehydroxytri-fluoromethylthiolation of alcohols via the umpolung reactivity of trifluoromethanesulfenamides Quentin Glenadel,Anis Tlili,Thierry Billard European Journal of Organic Chemistry, 2016, 2016 (11), pp.1955-1957. ⟨10.1002/ejoc.201600197⟩ Article dans une revue istex hal-01313146v1
Agonist and antagonist bind differently to 5-HT1A recptors during Alzheimer's disease : a post-mortem study with PET radiopharmaceutical B. Vidal,J. Sebti,M. Verdurand,S. Fieux,T. Billardet al. Neuropharmacology, 2016, 109, pp.88-95. ⟨10.1016/j.neuropharm.2016.05.009⟩ Article dans une revue hal-01484762v1
Multigram scale syntheses of first and second generation of trifluoromethanesulfenamide reagents Quentin Glenadel,Sébastien Alazet,François Baert,Thierry Billard Organic Process Research and Development, 2016, 20, pp.960-964. ⟨10.1021/acs.oprd.6b00062⟩ Article dans une revue hal-01484781v1
Direct ectrophilic (Benzenesulfonyl)difluoromethylthiolation with a shelf-stable reagent E. Ismalaj,D. Le Bars,T. Billard Angewandte Chemie International Edition, 2016, 55 (15), pp.4790-93 Article dans une revue hal-01313893v1
Benzyltrifluoromethyl (or Fluoroalkyl) selenide : reagent for electrophilic trifluoromethyl (or fluoroalkyl) selenolation Quentin Glenadel,Ermal Ismalaj,Thierry Billard Journal of Organic Chemistry, 2016, 81 (18), pp.8268-8275. ⟨10.1021/acs.joc.6b01344⟩ Article dans une revue hal-01484715v1
Synthetic approaches to trifluoromethoxy-substituted compounds Anis Tlili,Fabien Toulgoat,Thierry Billard Angewandte Chemie International Edition, 2016, 55 (39), pp.11726-11735. ⟨10.1002/anie.201603697⟩ Article dans une revue istex hal-01484721v1
Direct [ 11 C]Methylation of Amines from [11C]CO 2 for the Synthesis of PET Radiotracers François Liger,Ture Eijsbouts,Florence Cadarossanesaib,Christian Tourvieille,Didier Le Barset al. European Journal of Organic Chemistry, 2015, 2015 (29), pp.6434-6438. ⟨10.1002/ejoc.201500924⟩ Article dans une revue hal-03719209v1
Mild and soft catalyzed trifluoromethylthiolation of boronic acids : the crucial role of water Quentin Glenadel,Sébastien Alazet,Anis Tlili,Thierry Billard Chemistry - A European Journal, 2015, 21 (42), pp.14694-14698. ⟨10.1002/chem.201502338⟩ Article dans une revue istex hal-01313928v1
First and second generation of trifluoromethanesulfenamide reagent : a trifluoromethylthiolating comparison Quentin Glenadel,Sébastien Alazet,Thierry Billard Journal of Fluorine Chemistry, 2015, 179, pp.89-95. ⟨10.1016/j.jfluchem.2015.06.007⟩ Article dans une revue istex hal-01313914v1
Le fluor en chimie organique : une montée en puissance (Fluorine in organic chemistry gaining momentum) Thierry Billard,Emmanuel Magnier,Jean-Pierre Vors L'Actualité Chimique, 2015, 393-394, pp.56-61 Article dans une revue hal-01313987v1
Acid-catalyzed synthesis of α-trifluoromethylthiolated carbonyl compounds Sébastien Alazet,Ermal Ismalaj,Quentin Glenadel,Didier Le Bars,Thierry Billard European Journal of Organic Chemistry, 2015, 2015 (21), pp.4607-4610. ⟨10.1002/ejoc.201500710⟩ Article dans une revue istex hal-01313958v1
Preclinical evaluation of [18F]2FNQ1P as the first fluorinated serotonin 5-HT6 radioligand for PET imaging Guillaume Becker,Julie Colomb,Véronique Sgambato-Faure,Léon Tremblay,Thierry Billardet al. European Journal of Nuclear Medicine and Molecular Imaging, 2015, 42 (3), pp.495-502. ⟨10.1007/s00259-014-2936-y⟩ Article dans une revue hal-01128421v1
A Postmortem Study to Compare Agonist and Antagonist 5-HT1A Receptor-binding Sites in Alzheimer's Disease Guillaume Becker,Nathalie Streichenberger,Thierry Billard,Adrian Newman-Tancredi,Luc Zimmer CNS Neuroscience and Therapeutics, 2014, 20 (10), pp.930-934. ⟨10.1111/cns.12306⟩ Article dans une revue hal-01128433v1
Binding of the PET Radiotracer [18F]BF227 Does not Reflect the Presence of Alpha-Synuclein Aggregates in Transgenic Mice Élise Levigoureux,Sophie Lancelot,Caroline Bouillot,Fabien Chauveau,Mathieu Verdurandet al. Current Alzheimer Research, 2014, 11 (10), pp.955-960. ⟨10.2174/1567205011666141107154201⟩ Article dans une revue hal-01128444v1
PET radiotracers for molecular imaging of serotonin 5-HT1A receptors T. Billard,D. Le Bars,L. Zimmer Current Medicinal Chemistry, 2014, 21 (1), pp.70-80. ⟨10.2174/09298673113209990215⟩ Article dans une revue istex hal-00947714v1
Molecular imaging of the serotonin 5-HT7 receptors: from autoradiography to positron emission tomography L. Zimmer,T. Billard Reviews in the Neurosciences, 2014, 25 (3), pp.357-365. ⟨10.1515/revneuro-2014-0003⟩ Article dans une revue hal-00947703v1
Base-Catalyzed Electrophilic Trifluoromethylthiolation of Terminal Alkynes S. Alazet,L. Zimmer,T. Billard Angewandte Chemie International Edition, 2013, 52 (41), pp.10814-10817. ⟨10.1002/anie.201305179⟩ Article dans une revue hal-00948085v1
Radiosynthesis and Preclinical Evaluation of 18F-F13714 as a Fluorinated 5-HT1A Receptor Agonist Radioligand for PET Neuroimaging Laëtitia Lemoine,Guillaume Becker,Bernard Vacher,Thierry Billard,Sophie Lancelotet al. Journal of Nuclear Medicine, 2012, 53 (6), pp.969-976. ⟨10.2967/jnumed.111.101212⟩ Article dans une revue hal-00821174v1
2,2'-Bipyridine-3,3'-dicarboxylic carbohydrate esters and amides. Synthesis and preliminary evaluation as ligands in Cu(II)-catalysed enantioselective electrophilic fluorination. Aurélie Assalita,Thierry Billard,Stéphane Chambert,Bernard R. Langlois,Yves Queneauet al. Tetrahedron: Asymmetry, 2009, 20 (5), pp.593-601. ⟨10.1016/j.tetasy.2009.02.050⟩ Article dans une revue istex hal-01305046v1
Synthesis and biological evaluation of [18F]N-[2-(1-[(4-fluorophenyl)sulfonyl]-1H-indol-4-yloxy)ethyl]-N,N-dimethylamine as a potential 5-HT6 PET antagonist, S. Tang,M. Verdurand,B. Joseph,L. Lemoine,D. Daoustet al. Nuc. Med. Biol.,, 2007, 34, pp.995 Article dans une revue hal-00171079v1
Trifluoromethanesulfinic Acid Derivatives as Nucleophilic Trifluoromethylating Reagents David Inschauspe,Jean-Baptiste Sortais,Thierry Billard,Bernard Langlois SYNLETT, 2003, 2, pp.0233-0235. ⟨10.1055/s-2003-36788⟩ Article dans une revue hal-03639867v1
Fluoride-assisted trifluoromethylation of aromatic thiones with (trifluoromethyl)trimethylsilane Sylvie Large-Radix,Thierry Billard,Bernard R. Langlois Journal of Fluorine Chemistry, 2003, 124 (2), pp.147 - 149. ⟨10.1016/S0022-1139(03)00203-3⟩ Article dans une revue istex hal-01800170v1
Telomerization of vinylidene fluoride with alkyl (or aryl) trifluoromethanethiosulfonates Bruno Ameduri,Thierry Billard,Bernard Langlois Journal of Polymer Science Part A: Polymer Chemistry, 2002, 40 (24), pp.4538-4549. ⟨10.1002/pola.10535⟩ Article dans une revue hal-05083918v1
Electrophilic Trifluoromethylation of Vinyl Sulfides Bernard R. Langlois,Thierry Billard,Sophie Guérin,Sylvie Large,Nathalie Roidot-Perol Phosphorus, Sulfur, and Silicon and the Related Elements, 1999, 153 (1), pp.323 - 324. ⟨10.1080/10426509908546452⟩ Article dans une revue hal-01800163v1
Synthesis of Trifluoromethyl Selenides Thierry Billard,Bernard R. Langlois,Sylvie Large Phosphorus, Sulfur, and Silicon and the Related Elements, 1998, 136 (1), pp.521 - 524. ⟨10.1080/10426509808545987⟩ Article dans une revue hal-01800167v1
Preparation of trifluoromethyl sulfides or selenides from trifluoromethyl trimethylsilane and thiocyanates or selenocyanates Thierry Billard,Sylvie Large,Bernard R. Langlois Tetrahedron Letters, 1997, 38 (1), pp.65 - 68. ⟨10.1016/S0040-4039(96)02216-2⟩ Article dans une revue istex hal-01800102v1
A New Route to Thio- and Selenosulfonates from Disulfides and Diselenides. Application to the Synthesis of New Thio- and Selenoesters of Triflic Acid Thierry Billard,Bernard R. Langlois,Sylvie Large,Daniel Anker,Nathalie Roidotet al. Journal of Organic Chemistry, 1996, 61 (21), pp.7545 - 7550. ⟨10.1021/jo960619c⟩ Article dans une revue istex hal-01800094v1

Communication dans un congrès (13)

A versatile reagent: 2,4-Dinitro-trifluoromethoxybenzene (DNTFB). Thierry Billard 24th International Symposium on Fluorine Chemistry, Jul 2024, Shanghai, China Communication dans un congrès hal-04720232v1
Un isotope «non-naturel» du Fluor : Le Fluor-18 Thierry Billard 4ème édition du Colloque Français de Chimie du Fluor, May 2024, Le Mans, France Communication dans un congrès hal-04720226v1
2,4-Dinitro-trifluoromethoxybenzene (DNTFB): a promising reagent in fluorine chemistry Thierry Billard 26th Winter Fluorine Conference, Jan 2023, Clearwater Beach, United States Communication dans un congrès hal-04720203v1
New Reagents for Trifluoromethylchalcogenation Thierry Billard The XXIII International Conference on Organic Synthesis (23-ICOS), Oct 2023, Shanghai, China Communication dans un congrès hal-04720217v1
From Fluorinated Emerging Groups to Isotopic Labeled Molecules: New Tools for Medicinal Chemistry Thierry Billard Indo-French Seminar: Synergy of Chemistry and Biology towards Affordable Health, Nov 2023, Hyderabad, India Communication dans un congrès hal-04720223v1
Merging Fluorinated Moieties and Heteroatoms: Opportunities in Emerging Fluorinated Groups Design Thierry Billard 23rd International Symposium on Fluorine Chemistry, Jul 2023, Québec, Canada Communication dans un congrès hal-04720208v1
Trifluoromethylselenosulfonates: Versatile reagents in Fluorine chemistry Thierry Billard 20th European symposium on Fluorine Chemistry, Aug 2022, Berlin, Germany Communication dans un congrès hal-04720198v1
Fluorinated chalcogenosulfonates: Versatile reagents in fluorine chemistry Thierry Billard Pacifichem 2021, Dec 2021, Honolulu & Virtual, United States Communication dans un congrès hal-04720187v1
A screening assay in the search of an alpha-synuclein PET radioligand Mathieu Verdurand,Meriem Mendjel-Herda,Élise Levigoureux,Sophie Lancelot,Waël Zeinyehet al. World Molecular Imaging Congress (WMIC 2015), Sep 2015, Honolulu, United States Communication dans un congrès hal-01207698v1
A screening assay in the search of an alpha-synuclein PET radioligand Mathieu Verdurand,Meriem Mendjel-Herda,Élise Levigoureux,Sophie Lancelot,Waël Zeinyehet al. 10th annual meeting of the European Society for Molecular Imaging (ESMI) - European Molecular Imaging Meeting (EMIM), Mar 2015, Tübingen, Germany Communication dans un congrès hal-01207682v1
A post-mortem study to compare the 5-HT1A receptor binding of a PET agonist and a PET antagonist in Alzheimer's disease G. Becker,N. Streichenberger,T. Billard,B. Vacher,A. Newman-Tancrediet al. Annual Congress of the European Association of Nuclear Medicine 2013, Oct 2013, Lyon, France Communication dans un congrès hal-00948356v1
Preclinical evaluation of serotonin 5-HT6 receptor radioligands for PET imaging G. Becker,J. Colomb,T. Billard,L. Zimmer Annual Congress of the European Association of Nuclear Medicine 2013, Oct 2013, Lyon, France Communication dans un congrès hal-00948359v1
Radiosynthesis and radiopharmacological evaluation of fluorinated PET radioligands for the 5-HT6 receptors G. Becker,J. Colomb,T. Billard,L. Zimmer Society of Nuclear Medicine Congress 2013, Jun 2013, Vancouver, Canada. pp.326 Communication dans un congrès hal-00948473v1

Poster de conférence (5)

The SB-258585, a 5-HT6 antagonist that blocks serotonin transmission in striatum can induce loss of food motivation and behavioral disturbances in non-human primate. Léon Tremblay,Mathilde Pitoy,Lisa Gauthier,Julie Maulavé,Justine Debatisseet al. NeuroFrance, May 2023, Lyon, France Poster de conférence hal-04983922v1
Carbamoyl fluorides: from synthesis to radiochemistry Clémence Bonnefoy,Emmanuel Chefdeville,Armen Panossian,Gilles Hanquet,Frédéric R. Lerouxet al. 57th International Conference on Medicinal Chemistry, Jul 2023, Lille, France Poster de conférence hal-04720307v1
Carbamoyl Fluorides: From Synthesis to Radiochemistry Clémence Bonnefoy,Emmanuel Chefdeville,Armen Panossian,Gilles Hanquet,Frédéric R. Lerouxet al. 28th French-Japanese Symposium on Medicinal & Fine Chemistry, Oct 2023, Nice, France Poster de conférence hal-04720313v1
Carbamoyl fluoride as a potential new tag for fluorine-18 labeling Clémence Bonnefoy,Christian Tourvieille,Armen Panossian,Gilles Hanquet,Frédéric R. Lerouxet al. 24th International Symposium on Radiopharmaceutical Sciences, May 2022, Nantes, France Poster de conférence hal-04720303v1
2,4-Dinitro-trifluoromethoxybenzene: a promising reagent in fluorine chemistry Clémence Bonnefoy,Emmanuel Chefdeville,Christian Tourvielle,Armen Panossian,Gilles Hanquetet al. 55th Bürgenstock Conference, May 2022, Brunnen, Switzerland Poster de conférence hal-04720299v1

Chapitre d'ouvrage (2)

Serotonin receptor imaging by 18F-PET Thierry Billard,François Liger,Mathieu Verdurand Fluorine in Life Sciences: Pharmaceuticals, Medicinal Diagnostics, and Agrochemicals, Elsevier, pp.459-518, 2018, ⟨10.1016/B978-0-12-812733-9.00013-1⟩ Chapitre d'ouvrage hal-02382038v1
Towards CF3S group : from trifluoromethylationof sulfides to direct trifluoromethylthiolation F. Toulgoat,T. Billard Modern Synthesis Processes and Reactivity of Fluorinated Compounds : Progress in Fluorine, pp.141-179, 2017 Chapitre d'ouvrage hal-01484792v1