Thomas Freret Thomas FRERET

Publications

Article dans une revue (87)

TAAR1 activation normalizes dopamine signaling and decreases alcohol intake in SRKO mice after adolescent ethanol exposure Charles Houdant,Cassandre Rouanet,Valentine Bouet,Thomas Fréret,Michel Boulouardet al. Neuropharmacology, 2026, 289, pp.110884. ⟨10.1016/j.neuropharm.2026.110884⟩ Article dans une revue hal-05510254v1
Sexual Dimorphism of Synaptic Plasticity Changes in CA1 Hippocampal Networks in Hypergravity-Exposed Mice—New Insights for Cognition in Space Mathilde Wullen,Valentine Bouet,Thomas Freret,Jean-Marie Billard Cells, 2025, 14 (15), pp.1186. ⟨10.3390/cells14151186⟩ Article dans une revue hal-05196166v1
LOU/c/jall rat as a model of resilience in the context of streptozotocin-induced cognitive impairment Lucas Gephine,Sophie Corvaisier,Benoît Bernay,Thomas Freret,Marianne Leger Frontiers in Aging Neuroscience, 2025, 17, pp.1666397. ⟨10.3389/fnagi.2025.1666397⟩ Article dans une revue hal-05317162v1
Early involvement of D-serine in β-amyloid-dependent pathophysiology Jean-Marie Billard,E. Ploux,S. Largilliere,S. Corvaisier,L. Gorisse-Hussonnoiset al. Cellular and Molecular Life Sciences, 2025, 82 (1), pp.179. ⟨10.1007/s00018-025-05691-z⟩ Article dans une revue hal-05048837v1
Association between road traffic accidents and drugs belonging to the antiseizure medications class: A pharmacovigilance analysis in VigiBase Basile Chrétien,Sophie Nguyen,Charles Dolladille,Pierre‐marie Morice,Marie Heraudeauet al. British Journal of Clinical Pharmacology, 2023, 89 (1), pp.222-231. ⟨10.1111/BCP.15481⟩ Article dans une revue hal-04891941v1
5-HT6 Receptors Sex-Dependently Modulate Hippocampal Synaptic Activity through GABA Inhibition Caroline Lahogue,Jean-Marie Billard,Thomas Freret,Valentine Bouet Biomolecules, 2023, 13 (5), pp.751. ⟨10.3390/biom13050751⟩ Article dans une revue hal-04089829v1
Genetic Background Influence on Hippocampal Synaptic Plasticity: Frequency-Dependent Variations between an Inbred and an Outbred Mice Strain Candice Roux,Pierre Lecouflet,Jean-Marie Billard,Elise Esneault,Marianne Legeret al. International Journal of Molecular Sciences, 2023, 24 (5), pp.4304. ⟨10.3390/ijms24054304⟩ Article dans une revue hal-04212361v1
Improved NMDA Receptor Activation by the Secreted Amyloid-Protein Precursor-α in Healthy Aging: A Role for D-Serine? Jean-Marie Billard,Thomas Freret International Journal of Molecular Sciences, 2022, 23, ⟨10.3390/ijms232415542⟩ Article dans une revue hal-03910923v1
Pleiotropic prodrugs: Design of a dual butyrylcholinesterase inhibitor and 5-HT6 receptor antagonist with therapeutic interest in Alzheimer’s disease François-Xavier Toublet,Julien Lalut,Bérénice Hatat,Cédric Lecoutey,Audrey Daviset al. European Journal of Medicinal Chemistry, 2021, 210, pp.113059. ⟨10.1016/j.ejmech.2020.113059⟩ Article dans une revue hal-03082877v1
Fast Anxiolytic-Like Effect Observed in the Rat Conditioned Defensive Burying Test, after a Single Oral Dose of Natural Protein Extract Products Thomas Freret,Stacy Largilliere,Gerald Nee,Melanie Coolzaet,Sophie Corvaisieret al. Nutrients, 2021, 13 (7), pp.2445. ⟨10.3390/nu13072445⟩ Article dans une revue hal-03471908v1
Combination of MAP6 deficit, maternal separation and MK801 in female mice: A 3-hit animal model of neurodevelopmental disorder with cognitive deficits Solenn Percelay,Thomas Freret,Nicole Turnbull,Valentine Bouet,Michel Boulouard Behavioural Brain Research, 2021, 413, ⟨10.1016/j.bbr.2021.113473⟩ Article dans une revue hal-04316243v1
Memory Disorders Related to Hippocampal Function: The Interest of 5-HT4Rs Targeting Candice Roux,Marianne Leger,Thomas Freret International Journal of Molecular Sciences, 2021, 22 (21), pp.12082. ⟨10.3390/ijms222112082⟩ Article dans une revue hal-03471906v1
A new 3-hit mouse model of schizophrenia built on genetic, early and late factors Valentine Bouet,Solenn Percelay,Elise Leroux,Boubacar Diarra,Marianne Légeret al. Schizophrenia Research, 2021, 228, pp.519-528. ⟨10.1016/j.schres.2020.11.043⟩ Article dans une revue hal-04212366v1
Dopaminergic neuromodulation of prefrontal cortex activity requires the NMDA receptor co-agonist D-serine Glenn Dallérac,Xia Li,Pierre Lecouflet,Nadège Morisot,Silvia Sacchiet al. Proceedings of the National Academy of Sciences of the United States of America, 2021, 118 (23), pp.e2023750118. ⟨10.1073/pnas.2023750118⟩ Article dans une revue hal-03331836v1
Functional Dysregulations in CA1 Hippocampal Networks of a 3-Hit Mouse Model of Schizophrenia Solenn Percelay,Jean-Marie Billard,Thomas Freret,Annie Andrieux,Michel Boulouardet al. International Journal of Molecular Sciences, 2021, 22 (5), pp.2644. ⟨10.3390/ijms22052644⟩ Article dans une revue hal-03238069v1
Interplay between 5-HT4 receptors and GABAergic system within CA1 hippocampal synaptic plasticity Pierre Lecouflet,Candice Roux,B Potier,Marianne Leger,Elie Brunetet al. Cerebral Cortex, 2021, 31 (1), pp.694-701. ⟨10.1093/cercor/bhaa253⟩ Article dans une revue hal-03371418v1
Donecopride, a Swiss army knife with potential interest against Alzheimer's disease Christophe Rochais,Cédric Lecoutey,Katia Hamidouche,Patrizia Giannoni,Florence Gavenet al. British Journal of Pharmacology, In press, 177 (9), pp.1988-2005. ⟨10.1111/bph.14964⟩ Article dans une revue hal-02428730v1
Serine Racemase Deletion Affects the Excitatory/Inhibitory Balance of the Hippocampal CA1 Network Eva Ploux,Valentine Bouet,Inna Radzishevsky,Herman Wolosker,Thomas Freretet al. International Journal of Molecular Sciences, 2020, 21 (24), pp.9447. ⟨10.3390/ijms21249447⟩ Article dans une revue hal-03072318v1
Interplay between 5-HT4 Receptors and GABAergic System within CA1 Hippocampal Synaptic Plasticity Pierre Lecouflet,Candice M. Roux,Brigitte Potier,Marianne Leger,Elie Brunetet al. Cerebral Cortex, 2020, 31 (1), pp.694-701. ⟨10.1093/cercor/bhaa253⟩ Article dans une revue hal-03040826v1
Antipsychotic lurasidone: Behavioural and pharmacokinetic data in C57BL/6 mice Solenn Percelay,Marc Since,S. Lagadu,Thomas Freret,Valentine Bouetet al. Pharmacology Biochemistry and Behavior, 2020, 194, pp.172933. ⟨10.1016/j.pbb.2020.172933⟩ Article dans une revue hal-03602034v1
D-serine in physiological and pathological brain aging E. Ploux,T Freret,Jean-Marie Billard Biochimica et Biophysica Acta (BBA) - Proteins and Proteomics, 2020, pp.140542. ⟨10.1016/j.bbapap.2020.140542⟩ Article dans une revue hal-02947335v1
Author Correction: Dual orexin receptor antagonist induces changes in core body temperature in rats after exercise Tristan Martin,Yves Dauvilliers,Ouma-Chandrou Koumar,Valentine Bouet,Thomas Freretet al. Scientific Reports, 2020, 10 (1), pp.6030. ⟨10.1038/s41598-020-62685-6⟩ Article dans une revue hal-03518966v1
Long-Term Music Exposure Prevents Age-Related Cognitive Deficits in Rats Independently of Hippocampal Neurogenesis Lou Rizzolo,Marianne Leger,Sophie Corvaisier,Mathilde Groussard,Hervé Platelet al. Cerebral Cortex, 2020, 31 (1), pp.620-634. ⟨10.1093/cercor/bhaa247⟩ Article dans une revue hal-03019700v1
Dual orexin receptor antagonist induces changes in core body temperature in rats after exercise Tristan Martin,Yves Dauvilliers,Ouma-Chandrou Koumar,Valérie Bouet,Thomas Freretet al. Scientific Reports, 2019, 9 (1), pp.18432. ⟨10.1038/s41598-019-54826-3⟩ Article dans une revue hal-02400711v1
A Novel in vivo Anti-amnesic Agent, Specially Designed to Express Both Acetylcholinesterase (AChE) Inhibitory, Serotonergic Subtype 4 Receptor (5-HT4R) Agonist and Serotonergic Subtype 6 Receptor (5-HT6R) Inverse Agonist Activities, With a Potential Interest Against Alzheimer’s Disease Bérénice Hatat,Samir Yahiaoui,Cédric Lecoutey,Audrey Davis,Thomas Freretet al. Frontiers in Aging Neuroscience, 2019, 11, pp.148. ⟨10.3389/fnagi.2019.00148⟩ Article dans une revue hal-02399864v1
Inhibiting Acetylcholinesterase to Activate Pleiotropic Prodrugs with Therapeutic Interest in Alzheimer’s Disease François-Xavier Toublet,Cédric Lecoutey,Julien Lalut,Bérénice Hatat,Audrey Daviset al. Molecules, 2019, 24 (15), pp.2786. ⟨10.3390/molecules24152786⟩ Article dans une revue hal-02399906v1
Asc-1 transporter activation: an alternative to rescue age-related alterations in functional plasticity at rat hippocampal CA3/CA1 synapses Jean-Marie Billard,Thomas Freret Journal of Neurochemistry, 2018, 147 (4), pp.514-525. ⟨10.1111/jnc.14586⟩ Article dans une revue hal-02135230v1
Characterizing age-related decline of recognition memory and brain activation profile in mice Hassina Belblidia,Marianne Leger,Abdelmalek Abdelouadoud,Anne Quiedeville,Floriane Caloceret al. Experimental Gerontology, 2018, 106, pp.222-231. ⟨10.1016/j.exger.2018.03.006⟩ Article dans une revue hal-01733066v1
Evaluation of the impact of S-adenosylmethionine-dependent methyltransferase inhibitor, 3-deazaneplanocin A, on tissue injury and cognitive function in mice Eva Lhuissier,Juliette Aury-Landas,Valentine Bouët,Céline Bazille,Yohann Repesseet al. Oncotarget, 2018, 9 (29), pp.20698 - 20708. ⟨10.18632/oncotarget.25062⟩ Article dans une revue hal-01796395v1
Repeated dexamphetamine treatment alters the dopaminergic system and increases the phMRI response to methylphenidate Anouk Schrantee,Jordi Tremoleda,Marzena Wylezinska-Arridge,Valentine Bouet,Peter Hesselinget al. PLoS ONE, 2017, 12 (2), pp.e0172776. ⟨10.1371/journal.pone.0172776⟩ Article dans une revue hal-02135218v1
Deletion of the serotonin receptor type 7 disrupts the acquisition of allocentric but not egocentric navigation strategies in mice Gregory Beaudet,Christelle Jozet-Alves,Rachel Asselot,Pascale Schumann-Bard,Thomas Freretet al. Behavioural Brain Research, 2017, 320 (1), pp.179 - 185. ⟨10.1016/j.bbr.2016.12.006⟩ Article dans une revue hal-01472663v1
LP-211, a selective 5-HT 7 receptor agonist, increases novelty-preference and promotes risk-prone behavior in rats G. Beaudet,E. Paizanis,F. Zoratto,E. Lacivita,M. Leopoldoet al. Synapse, 2017, 71 (12), pp.e21995. ⟨10.1002/syn.21995⟩ Article dans une revue hal-02193575v1
Co-modulation of an allosteric modulator of nicotinic receptor-cholinesterase inhibitor (galantamine) and a 5-HT4 receptor agonist (RS-67333): effect on scopolamine-induced memory deficit in the mouse Thomas Freret,Véronique Lelong-Boulouard,Pierre Lecouflet,Katia Hamidouche,François Dauphinet al. Psychopharmacology, 2017, 234 (15), pp.2365-2374. ⟨10.1007/s00213-017-4664-z⟩ Article dans une revue hal-02135214v1
Long-Lasting Effects of Chronic Intermittent Alcohol Exposure in Adolescent Mice on Object Recognition and Hippocampal Neuronal Activity. G Beaudet,S Valable,J Bourgine,V Lelong-Boulouard,L Lanfumeyet al. Alcoholism: Clinical and Experimental Research, 2016, 40 (12), pp.2591-2603. ⟨10.1111/acer.13256⟩ Article dans une revue istex hal-01576066v1
Design, synthesis, and pharmacological evaluation of multitarget-directed ligands with both serotonergic subtype 4 receptor (5-HT 4 R) partial agonist and 5-HT 6 R antagonist activities, as potential treatment of Alzheimer’s disease Samir Yahiaoui,Katia Hamidouche,Céline Ballandonne,Audrey Davis,Jana Sopkova-de Oliveira Santoset al. European Journal of Medicinal Chemistry, 2016, 121, pp.283-293. ⟨10.1016/j.ejmech.2016.05.048⟩ Article dans une revue hal-02043759v1
Chronic activation of 5-HT4 receptors or blockade of 5-HT6 receptors improve memory performances Anne Quiedeville,Michel Boulouard,Katia Hamidouche,Virginie da Silva Costa-Aze,Gerald Neeet al. Behavioural Brain Research, 2015, 293, pp.10-17. ⟨10.1016/j.bbr.2015.07.020⟩ Article dans une revue hal-02043824v1
Therapeutic Potential of 5-HT 6 Receptor Agonists Delphine Karila,Thomas Freret,Valentine Bouet,Michel Boulouard,Patrick Dallemagneet al. Journal of Medicinal Chemistry, 2015, 58 (20), pp.7901-7912. ⟨10.1021/acs.jmedchem.5b00179⟩ Article dans une revue hal-02043781v1
Time decay of object, place and temporal order memory in a paradigm assessing simultaneously episodic-like memory components in mice Hassina Belblidia,Abdelmalek Abdelouadoud,Christelle Jozet-Alves,Hélène Dumas,Thomas Freretet al. Behavioural Brain Research, 2015, 286, pp.80--84. ⟨10.1016/j.bbr.2015.02.043⟩ Article dans une revue hal-01472655v1
Usefulness of Time-Point Serum Cortisol and ACTH Measurements for the Adjustment of Glucocorticoid Replacement in Adrenal Insufficiency Elise Rousseau,Michael Joubert,Géraldine Trzepla,Jean Jacques Parienti,Thomas Freretet al. PLoS ONE, 2015, 10 (8), pp.e0135975. ⟨10.1371/journal.pone.0135975⟩ Article dans une revue hal-02190958v1
Effects of acute administration of melatonin on attentional, executive, and working memory processes in rats Christophe Liet,Fella Amenouche,Thomas Freret,Michel Boulouard,Benoit Mauvieuxet al. Fundamental & Clinical Pharmacology, 2015, 29 (5), pp.472-477. ⟨10.1111/fcp.12134⟩ Article dans une revue istex hal-02193380v1
Effects of long-term methylphenidate treatment in adolescent and adult rats on hippocampal shape, functional connectivity and adult neurogenesis K. van Der Marel,V. Bouet,G.F. Meerhoff,T. Freret,M. Boulouardet al. Neuroscience, 2015, 309, pp.243-258. ⟨10.1016/j.neuroscience.2015.04.044⟩ Article dans une revue hal-02193376v1
Novel Multitarget-Directed Ligands (MTDLs) with Acetylcholinesterase (AChE) Inhibitory and Serotonergic Subtype 4 Receptor (5-HT 4 R) Agonist Activities As Potential Agents against Alzheimer’s Disease: The Design of Donecopride Cédric Lecoutey,Cédric Lecoutey,Florence Gaven,Patrizia Giannoni,Katia Hamidoucheet al. Journal of Medicinal Chemistry, 2015, 58 (7), pp.3172-3187. ⟨10.1021/acs.jmedchem.5b00115⟩ Article dans une revue hal-02043873v1
Mechanisms underlying the neuroprotective effect of brain reserve against late life depression Thomas Freret,Pierrette Gaudreau,Pascale Schumann-Bard,Jean-Marie Billard,Aurel Popa-Wagner Journal of Neural Transmission, 2015, 122 (S1), pp.55-61. ⟨10.1007/s00702-013-1154-2⟩ Article dans une revue hal-02325092v1
Environmental Enrichment Duration Differentially Affects Behavior and Neuroplasticity in Adult Mice Marianne Leger,Eleni Paizanis,Kwamivi Dzahini,Anne Quiedeville,Valentine Bouetet al. Cerebral Cortex, 2015, 25 (11), pp.4048-4061. ⟨10.1093/cercor/bhu119⟩ Article dans une revue hal-02135292v1
Spatial memory deficit across aging: current insights of the role of 5-HT7 receptors Gregory Beaudet,Valentine Bouet,Christelle Jozet-Alves,Pascale Schumann-Bard,Francois Dauphinet al. Frontiers in Behavioral Neuroscience, 2015, 8, pp.448. ⟨10.3389/fnbeh.2014.00448⟩ Article dans une revue hal-01472654v1
Dual Histamine H3R/Serotonin 5-HT4R Ligands with Antiamnesic Properties: Pharmacophore-Based Virtual Screening and Polypharmacology. Alban Lepailleur,Thomas Freret,Stéphane Lemaître,Michel Boulouard,François Dauphinet al. Journal of Chemical Information and Modeling, 2014, 54 (6), pp.1773-1784. ⟨10.1021/ci500157n⟩ Article dans une revue hal-01064770v1
Design of donecopride, a dual serotonin subtype 4 receptor agonist/acetylcholinesterase inhibitor with potential interest for Alzheimer's disease treatment Cédric Lecoutey,Damien Hedou,Thomas Freret,Patrizia Giannoni,Florence Gavenet al. Proceedings of the National Academy of Sciences of the United States of America, 2014, 111 (36), pp.E3825--30. ⟨10.1073/pnas.1410315111⟩ Article dans une revue hal-01800439v2
Iron overload accelerates neuronal amyloid-β production and cognitive impairment in transgenic mice model of Alzheimer's disease Javier Becerril-Ortega,Karim Bordji,Thomas Freret,Travis Rush,Alain Buisson Neurobiology of Aging, 2014, 35 (10), pp.2288 - 2301. ⟨10.1016/j.neurobiolaging.2014.04.019⟩ Article dans une revue istex hal-01626647v1
Genomic transcriptional profiling in LOU/C/Jall rats identifies genes for successful aging Véronique Paban,Jean-Marie Billard,Valentine Bouet,Thomas Freret,Michel Boulouardet al. Brain Structure and Function, 2013, 218 (6), pp.1501-1512. ⟨10.1007/s00429-012-0472-8⟩ Article dans une revue istex hal-02325134v1
Object recognition test in mice Marianne Leger,Anne Quiedeville,Valentine Bouet,Benoît Haelewyn,Michel Boulouardet al. Nature Protocols, 2013, 8 (12), pp.2531-2537. ⟨10.1038/nprot.2013.155⟩ Article dans une revue hal-02135259v1
New orally effective 3-(2-nitro)phenylpropanamide analgesic derivatives: Synthesis and antinociceptive evaluation Marc Since,Thomas Freret,Gerald Nee,Thierry Terme,Patrice Vanelleet al. European Journal of Medicinal Chemistry, 2013, 69, pp.728--734. ⟨10.1016/j.ejmech.2013.08.041⟩ Article dans une revue istex hal-01460473v1
Rescue of cognitive aging by long-lasting environmental enrichment exposure initiated before median lifespan T. Freret,Jean-Marie Billard,P. Schumann-Bard,P. Dutar,F. Dauphinet al. Neurobiology of Aging, 2012, 33 (5), pp.1005.e1-1005.e10. ⟨10.1016/j.neurobiolaging.2011.09.028⟩ Article dans une revue istex hal-02325180v1
Influence of vestibular input on spatial and nonspatial memory and on hippocampal NMDA receptors. S. Besnard,M. L. Machado,G. Vignaux,M. Boulouard,A. Coquerelet al. Hippocampus, 2012, 22 (4), pp.814-26. ⟨10.1002/hipo.20942⟩ Article dans une revue istex hal-00866441v1
Influence of anxiety in spatial memory impairments related to the loss of vestibular function in rat. M. L. Machado,V. Lelong-Boulouard,P. F. Smith,T. Freret,B. Philoxeneet al. Neuroscience, 2012, 218, pp.161-9. ⟨10.1016/j.neuroscience.2012.05.029⟩ Article dans une revue istex hal-00866396v1
Synergistic effect of acetylcholinesterase inhibition (donepezil) and 5-HT(4) receptor activation (RS67333) on object recognition in mice. Thomas Freret,Valentine Bouet,Anne Quiedeville,Gérald Nee,Patrick Dallemagneet al. Behavioural Brain Research, 2012, 230 (1), pp.304-8. ⟨10.1016/j.bbr.2012.02.012⟩ Article dans une revue istex hal-00862757v1
Rescue of cognitive aging by long-lasting environmental enrichment exposure initiated before median lifespan. T. Freret,J.-M. Billard,P. Schumann-Bard,P. Dutar,F. Dauphinet al. Neurobiol Aging, 2012, 33 (5), pp.1005.e1-10. ⟨10.1016/j.neurobiolaging.2011.09.028⟩ Article dans une revue istex hal-00866400v1
Vezatin is essential for dendritic spine morphogenesis and functional synaptic maturation. Lydia Danglot,Thomas Freret,Nicolas Le Roux,Nicolas Narboux Nême,Andrea Burgoet al. Journal of Neuroscience, 2012, 32 (26), pp.9007-9022. ⟨10.1523/JNEUROSCI.3084-11.2012⟩ Article dans une revue hal-00776396v1
A biphasic and brain-region selective down-regulation of cyclic adenosine monophosphate concentrations supports object recognition in the rat. Maïte Hotte,François Dauphin,Thomas Freret,Michel Boulouard,Guenaëlle Levallet PLoS ONE, 2012, 7 (2), pp.e32244. ⟨10.1371/journal.pone.0032244⟩ Article dans une revue hal-00862771v1
Spatial and non-spatial performance in mutant mice devoid of otoliths. M. L. Machado,N. Kroichvili,T. Freret,B. Philoxène,V. Lelong-Boulouardet al. Neuroscience Letters, 2012, 522 (1), pp.57-61. ⟨10.1016/j.neulet.2012.06.016⟩ Article dans une revue istex hal-00866394v1
Genomic transcriptional profiling in LOU/C/Jall rats identifies genes for successful aging. Véronique Paban,Jean-Marie Billard,Valentine Bouet,Thomas Freret,Michel Boulouardet al. Brain Structure and Function, 2012, 218 (6), pp.1501-1512. ⟨10.1007/s00429-012-0472-8⟩ Article dans une revue istex hal-00862299v1
Synergistic effect of acetylcholinesterase inhibition (donepezil) and 5-HT4 receptor activation (RS67333) on object recognition in mice. Thomas Freret,Valentine Bouet,Anne Quiedeville,Gérald Nee,Patrick Dallemagneet al. Behavioural Brain Research, 2012, 230 (1), pp.304-308. ⟨10.1016/j.bbr.2012.02.012⟩ Article dans une revue istex hal-00821461v1
Age-dependent effects of chronic fluoxetine treatment on the serotonergic system one week following treatment. Valentine Bouet,Anne Klomp,Thomas Freret,Marzena Wylezinska-Arridge,Jordi Lopez-Tremoledaet al. Psychopharmacology, 2012, 221 (2), pp.329-39. ⟨10.1007/s00213-011-2580-1⟩ Article dans une revue istex hal-00862306v1
Maternal hypertension during pregnancy modifies the response of the immature brain to hypoxia-ischemia: sequential MRI and behavioral investigations. Annelise Letourneur,Thomas Freret,Simon Roussel,Michel Boulouard,Didier Divouxet al. Experimental Neurology, 2012, 233 (1), pp.264-72. ⟨10.1016/j.expneurol.2011.10.014⟩ Article dans une revue istex hal-00862822v1
Environmental enrichment improves recent but not remote memory in association with a modified brain metabolic activation profile in adult mice. Marianne Leger,Valentine Bouet,Thomas Freret,Anne-Sophie Darmaillacq,Matthieu Dacheret al. Behavioural Brain Research, 2012, 228 (1), pp.22-9. ⟨10.1016/j.bbr.2011.11.022⟩ Article dans une revue istex hal-00862779v1
Post-stroke depression: mechanisms, translation and therapy. Isabelle Loubinoux,Golo Kronenberg,Matthias Endres,Pascale Schumann-Bard,Thomas Freretet al. Journal of Cellular and Molecular Medicine, 2012, 16 (9), pp.1961-9. ⟨10.1111/j.1582-4934.2012.01555.x⟩ Article dans une revue hal-00862834v1
Repeated mild hypoxic exposures decrease anxiety-like behavior in the adult mouse together with an increased brain adrenomedullin gene expression. Claire Leconte,Marianne Léger,Michel Boulouard,Emmanuelle Tixier,Thomas Fréretet al. Behavioural Brain Research, 2012, 230 (1), pp.78-84. ⟨10.1016/j.bbr.2012.01.054⟩ Article dans une revue istex hal-00862777v1
Environmental enrichment enhances episodic-like memory in association with a modified neuronal activation profile in adult mice. Marianne Leger,Anne Quiedeville,Eleni Paizanis,Sharuja Natkunarajah,Thomas Freretet al. PLoS ONE, 2012, 7 (10), pp.e48043. ⟨10.1371/journal.pone.0048043⟩ Article dans une revue hal-00862786v1
Effect of pre- versus post-weaning environmental disturbances on social behaviour in mice. Valentine Bouet,Blandine Lecrux,Gwenaelle Tran,Thomas Freret Neuroscience Letters, 2011, 488 (2), pp.221-4. ⟨10.1016/j.neulet.2010.11.033⟩ Article dans une revue istex hal-00862841v1
Continuous enriched environment improves learning and memory in adult NMRI mice through theta burst-related-LTP independent mechanisms but is not efficient in advanced aged animals. Valentine Bouet,Thomas Freret,Patrick Dutar,Jean-Marie Billard,Michel Boulouard Mechanisms of Ageing and Development, 2011, 132 (5), pp.240-8. ⟨10.1016/j.mad.2011.04.006⟩ Article dans une revue istex hal-00862993v1
On the importance of long-term functional assessment after stroke to improve translation from bench to bedside. Thomas Freret,Pascale Schumann-Bard,Michel Boulouard,Valentine Bouet Experimental and Translational Stroke Medicine, 2011, 3, pp.6. ⟨10.1186/2040-7378-3-6⟩ Article dans une revue hal-00862997v1
Continuous enriched environment improves learning and memory in adult NMRI mice through theta burst-related-LTP independent mechanisms but is not efficient in advanced aged animals Valentine Bouet,Thomas Freret,Patrick Dutar,Jean-Marie Billard,Michel Boulouard Mechanisms of Ageing and Development, 2011, 132 (5), pp.240-248. ⟨10.1016/j.mad.2011.04.006⟩ Article dans une revue istex hal-02325196v1
Predicting sensorimotor and memory deficits after neonatal ischemic stroke with reperfusion in the rat. Valentine Bouet,Thomas Freret,Steve Ankri,Madeleine Bezault,Sylvain Renolleauet al. Behavioural Brain Research, 2010, 212 (1), pp.56-63. ⟨10.1016/j.bbr.2010.03.043⟩ Article dans une revue istex hal-00863083v1
Behavioral deficits after distal focal cerebral ischemia in mice: Usefulness of adhesive removal test. Thomas Freret,Valentine Bouet,Claire Leconte,Simon Roussel,Laurent Chazalvielet al. Behavioral Neuroscience, 2009, 123 (1), pp.224-30. ⟨10.1037/a0014157⟩ Article dans une revue hal-00863264v1
Improvements of the Stroke Model Guidelines -Animal body weight and long-term functional concerns Thomas Freret,Valentine Bouet Journal of Experimental Stroke & Translational Medicine, 2009 Article dans une revue hal-04358233v1
Delayed hypoxic postconditioning protects against cerebral ischemia in the mouse. Claire Leconte,Emmanuelle Tixier,Thomas Freret,Jérôme Toutain,Romaric Saulnieret al. Stroke, 2009, 40 (10), pp.3349-55. ⟨10.1161/STROKEAHA.109.557314⟩ Article dans une revue hal-00863295v1
The adhesive removal test: a sensitive method to assess sensorimotor deficits in mice. Valentine Bouet,Michel Boulouard,Jérôme Toutain,Didier Divoux,Myriam Bernaudinet al. Nature Protocols, 2009, 4 (10), pp.1560-4. ⟨10.1038/nprot.2009.125⟩ Article dans une revue hal-00863258v1
Tetrahydroisoquinolines as dopaminergic ligands: 1-Butyl-7-chloro-6-hydroxy-tetrahydroisoquinoline, a new compound with antidepressant-like activity in mice. Inmaculada Berenguer,Noureddine El Aouad,Sebastián Andujar,Vanessa Romero,Fernando Suvireet al. Bioorganic and Medicinal Chemistry, 2009, 17 (14), pp.4968-80. ⟨10.1016/j.bmc.2009.05.079⟩ Article dans une revue istex hal-00863255v1
Combined therapeutic strategy using erythropoietin and mesenchymal stem cells potentiates neurogenesis after transient focal cerebral ischemia in rats. Elise Esneault,Emilie Pacary,Dauphou Eddi,Thomas Freret,Emmanuelle Tixieret al. Journal of Cerebral Blood Flow and Metabolism, 2008, 28 (9), pp.1552-63. ⟨10.1038/jcbfm.2008.40⟩ Article dans une revue hal-00863330v1
Intraluminal thread model of focal stroke in the non-human primate Thomas Freret,Valentine Bouet,Jérôme Toutain,Romaric Saulnier,Palma Pro-Sistiagaet al. Journal of Cerebral Blood Flow and Metabolism, 2008, 28 (4), pp.786-96. ⟨10.1038/sj.jcbfm.9600575⟩ Article dans une revue hal-00863332v1
Long-term evaluation of sensorimotor and mnesic behaviour following striatal NMDA-induced unilateral excitotoxic lesion in the mouse Benoît Haelewyn,Thomas Freret,Emilie Pacary,Pascale Schumann-Bard,Michel Boulouardet al. Behavioural Brain Research, 2007, 178, pp.235-243. ⟨10.1016/j.bbr.2006.12.023⟩ Article dans une revue istex hal-00867870v1
Long-term evaluation of sensorimotor and mnesic behaviour following striatal NMDA-induced unilateral excitotoxic lesion in the mouse. Benoît Haelewyn,Thomas Freret,Emilie Pacary,Pascale Schumann-Bard,Michel Boulouardet al. Behavioural Brain Research, 2007, 178 (2), pp.235-43. ⟨10.1016/j.bbr.2006.12.023⟩ Article dans une revue istex hal-00178443v1
Sensorimotor and cognitive deficits after transient middle cerebral artery occlusion in the mouse. Valentine Bouët,Thomas Freret,Jérôme Toutain,Didier Divoux,Michel Boulouardet al. Experimental Neurology, 2007, 203 (2), pp.555-67. ⟨10.1016/j.expneurol.2006.09.006⟩ Article dans une revue istex hal-00178296v1
Effect of hypoxic preconditioning on brain genomic response before and following ischemia in the adult mouse: identification of potential neuroprotective candidates for stroke Y. Tang,E. Pacary,T. Freret,D. Divoux,E. Petitet al. Neurobiology of Disease, 2006, 21, pp.18-28 Article dans une revue hal-00018635v1
Delayed administration of deferoxamine reduces brain damage and promotes functional recovery after transient focal cerebral ischemia in the rat. Thomas Freret,Samuel Valable,Laurent Chazalviel,Romaric Saulnier,Eric T Mackenzieet al. European Journal of Neuroscience, 2006, 23 (7), pp.1757-65. ⟨10.1111/j.1460-9568.2006.04699.x⟩ Article dans une revue istex hal-00865370v1
Delayed administration of deferoxamine reduces brain damage and promotes functional recovery after transient focal cerebral ischemia in the rat Thomas Freret,Samuel Valable,Laurent Chazalviel,Romaric Saulnier,Eric Mackenzieet al. European Journal of Neuroscience, 2006, 23 (7), pp.1757-1765. ⟨10.1111/j.1460-9568.2006.04699.x⟩ Article dans une revue istex hal-00023477v1
Long-term functional outcome following transient middle cerebral artery occlusion in the rat: correlation between brain damage and behavioral impairment. Thomas Freret,Laurent Chazalviel,Simon Roussel,Myriam Bernaudin,Pascale Schumann-Bardet al. Behavioral Neuroscience, 2006, 120 (6), pp.1285-98. ⟨10.1037/0735-7044.120.6.1285⟩ Article dans une revue hal-00865366v1
Sensorimotor and cognitive deficits after transient middle cerebral artery occlusion in the mouse Valentine Bouet,Thomas Freret,J. Toutain,Didier Divoux,Michel Boulouardet al. Experimental Neurology, 2006, 203, pp.55-567. ⟨10.1016/j.expneurol.2006.09.006⟩ Article dans une revue istex hal-00867774v1

Communication dans un congrès (6)

L’approche &quot;Deformation-based morphometry&quot; (DBM) est-elle pertinente pour identifier les changements macrostructuraux cérébraux radio-induits ? Carole Brunaud,Samuel Valable,Gwenn Ropars,Fatima-Azzahra Dwiri,Mikaël Naveauet al. 7ème congrès de la SFRMBM, Mar 2025, Saint Malo, France Communication dans un congrès hal-05046508v1
Analyse IRM par Deformation Based Morphometry (DBM) pour la mise en évidence des altérations cérébrales radio-induites dans un modèle de rat adulte. Carole Brunaud,Samuel Valable,Gwenn Ropars,Fatima-Azzahra Dwiri,Mikaël Naveauet al. Journée annuelle de l'axe 3 "Imagerie et adaptation thérapeutique" du Cancéropôle Nord-Ouest, Dec 2024, Rouen, France Communication dans un congrès hal-04835395v1
Sex-related impairment of synaptic plasticity in the hippocampus of hypergravity-exposed mice: new insights for cognition in space Wullen Mathilde,Thomas Freret,Valentine Bouet,Jean-Marie Billard FENS Forum 2024, FENS, Jun 2024, Wien, Austria Communication dans un congrès hal-04624901v1
Evaluation par Deformation based Morphometry (DBM) des altérations cérébrales radio-induites Carole Brunaud,Samuel Valable,Gwenn Ropars,Fatima-Azzahra Dwiri,Mikaël Naveauet al. 2ème Journée Scientifique de la Structure Fédérative Normandie Oncologie, Nov 2024, Caen, France Communication dans un congrès hal-04835252v1
Blood biomarkers mediate the association between age and gait speed Antoine Langeard,Evrim Gökçe,Thomas Freret Congrès SOFPEL, Nov 2023, Rouen, France Communication dans un congrès hal-04330099v1
Evaluation préclinique de nanoémulsions polyvalentes comme vecteurs d’un nouvel inhibiteur de Mcl-1, le Pyridoclax : application au traitement des cancers de l’ovaire (PYRINANO) Aurélie Malzert-Fréon,Anne-Claire Groo,Siham Hedir,Marc Since,Martina de Pascaleet al. 10émes journées scientifiques du cancéropole nord-ouest, May 2017, Deauville, France Communication dans un congrès hal-02295794v1

Poster de conférence (24)

Detection of radiation-induced brain lesions in a rat model, using deformation-based morphometry (DBM), a method involving magnetic resonance imaging (MRI) Carole Brunaud,Samuel Valable,Gwenn Ropars,Fatima-Azzahra Dwiri,Mikaël Naveauet al. 9th International Cognition and Cancer Task Force Conference (ICCTF 2025), Mar 2025, Caen, France Poster de conférence hal-05046555v1
Pharmacokinetic and safety of a novel pleiotropic compound in C57BL/6J mice with potential therapeutic interest in Alzheimer’s disease Caroline Lahogue,Stacy Largilliere,Gérald Nee,Alice Wang,Stéphanie Lagaduet al. FENS 2024, Jun 2024, Vienne, Austria Poster de conférence hal-04632974v1
Short and long-term cognitive impairment in mice exposed to hypergravity depends on sex Wullen Mathilde,Jean-Marie Billard,Thomas Freret,Valentine Bouet Journée de l'école doctorale, May 2024, Caen, France Poster de conférence hal-04669804v1
Treatment strategy targeting 5-HT6R in an innovative animal model of Schizophrenia Caroline Lahogue,Michel Boulouard,François Menager,Thomas Freret,Jean-Marie Billardet al. FENS 2024, Jun 2024, Vienne, Austria Poster de conférence hal-04634813v1
Lou/c/Jall rat as a resilience model in the context of sporadic Alzheimer’s disease induced by streptozotocin. Lucas Gephine,Antoine Huret,Sophie Corvaisier,Gerald Nee,Thomas Freretet al. FENS Forum 2024, Jun 2024, Vienne (AUT), France Poster de conférence hal-04669652v1
LOU/C/Jall rats show preserved memory performance in sporadic model of Alzheimer's disease induced by streptozotocin Lucas Gephine,Antoine Huret,Stacy Largilliere,Sophie Corvaisier,Thomas Freretet al. GDR Mémoire, Oct 2023, Carry-le -Rouet, France Poster de conférence hal-04669646v1
Hippocampal functional adaptation to hypergravity exposure : new insights for cognitive alterations in astronauts Wullen Mathilde,Valentine Bouet,Thomas Freret,Jean-Marie Billard Groupe De Recherche interdisciplinaire Mémoire, Oct 2023, Carry-le-rouet, France Poster de conférence hal-04669799v1
Sex-dependent 5-HT6Rs effects on hippocampal synaptic activity Caroline Lahogue,Jean-Marie Billard,Thomas Freret,Valentine Bouet NeuroFrance 2023 -, May 2023, Lyon, France. Poster de conférence hal-04216532v1
Contrôle et correction des variables physiologiques en IRM fonctionnelle cérébrale chez l'homme et le rat anesthésié Marin Mauboussin,Coline Vanschamelhout,Nicolas Delcroix,Marc Joliot,Thomas Freretet al. 6ème Congrès de la Société française de résonance magnétique en biologie et médecine, Mar 2023, Paris, France. Poster de conférence hal-04065412v1
Vulnerability of Spatial Pattern Separation in a transgenic mouse model of Alzheimer's Disease Lucas Gephine,Candice Roux,Thomas Freret,Michel Boulouard,Marianne Leger FENS Forum 2022, Jul 2022, Paris, France Poster de conférence hal-04669480v1
Can physiological signals estimation improve fMRI connectivity assessment in anesthetized rats? Mikael Naveau,Coline Vanschamelhout,Marin Mauboussin,Romaric Saulnier,Palma Pro-Sistiagaet al. OHBM2022, Jun 2022, Glasgow, United Kingdom. Poster de conférence hal-03878758v1
A robust link between d-serine and amyloid pathology in a mouse model E Ploux,L. Gorisse,I Radzishevsky,H Wolosker,Thomas Freretet al. 4th International Conference of D-Amino Acid Research, Sep 2019, Tokyo, Japan Poster de conférence hal-02331029v1
D-serine is involved in the β-amyloid-related pathophysiology in Alzheimer’s disease E Ploux,L. Gorisse,I Radzishevsky,H Wolosker,T Freretet al. 14eme Colloque de la Société des Neurosciences, May 2019, Marseille, France Poster de conférence hal-02331616v1
Multiparametric and longitudinal characterization of whole-brain irradiation model in the rat Elodie Pérès,Gwenn Ropars,Fatima-Azzahra Dwiri,Jérôme Toutain,Carole Brunaudet al. 17th European Network for Light Ion Hadron Therapy (ENLIGHT), Jul 2019, Caen, France Poster de conférence hal-02265960v1
Combining adverse factors to build a new 3-hit model of schizophrenia Solenn Percelay,Valentine Bouët,Thomas Freret,Michel Boulouard XXIIème journées de l'Ecole Doctorale normande de Biologie Intégrétive, Santé, Environnement, Mar 2019, Caen, France. , 2019 Poster de conférence hal-02135476v1
Mimicking schizophrenia symptoms in mice by combining factors: genetic, early environmental stress and late pharmacological conditioning Valentine Bouët,Solenn Percelay,Nicole Turnbull,Thomas Freret,Michel Boulouard NeuroFrance, May 2019, Marseille, France Poster de conférence hal-02492831v1
Altering glutamate transmission in combination with an early post-natal stress to mimic schizophrenia in male and female mice F Menager,Solenn Percelay,T. Freret,M. Boulouard,Jean-Marie Billardet al. Journée Normande de Recherche Biomédicale, Nov 2019, Caen, France Poster de conférence hal-02363095v1
Impact of d-serine depletion in the β-amyloid cascade related to Alzheimer’s disease T. Freret,E Ploux,L. Gorisse,I Radzishevsky,H Woloskeret al. Annual Meeting of the Society for Neuroscience (SFN), Oct 2019, Chicago, United States Poster de conférence hal-02330837v1
New 3-hit model of schizophrenia: behavioral and electrophysiological investigations Solenn Percelay,Valentine Bouet,Jean-Marie Billard,Thomas Freret,Michel Boulouard 23ème journée de LARC, Sep 2019, Nantes, France. ⟨10.4103/ipj.ipj_30_15⟩ Poster de conférence hal-02363078v1
D-serine contributes to β-amyloid-dependant pathophysiology in Alzheimer’s disease J-M Billard,E Ploux,L. Gorisse,T Freret 11th FENS Forum of Neuroscience, Jun 2018, Berlin, Germany Poster de conférence hal-02331264v1
New mouse model of schizophrenia: &quot;3 hits&quot; model, genetic and environmental factors Solenn Percelay,Valentine Bouët,Thomas Freret,Michel Boulouard XXIème journées de l'Ecole Doctorale normande de Biologie Intégrative, Santé, Environnement, Mar 2018, Rouen, France. 2018 Poster de conférence hal-02135458v1
Schizophrenia: validity of a 3-hit mouse model Solenn Percelay,Thomas Freret,Boubacar Diarra,Nicolas Delcroix,Elise Lerouxet al. 11th Federation of European Neuroscience Societies Forum of Neuroscience, Jul 2018, Berlin, Germany. , 2018 Poster de conférence hal-02135529v1
5-HT7 receptors are strongly implicated in allocentric navigation strategy in mice Gregory Beaudet,Christelle Jozet-Alves,Thomas Freret,Pascale Schumann-Bard,Valentine Bouetet al. 19ème Congrès de la Société Française de Pharmacologie et de Thérapeutique, Apr 2015, Caen, France Poster de conférence hal-02436415v1
The role of serotonin 5-HT7 receptors in spatial navigation in the mouse Gregory Beaudet,Christelle Jozet-Alves,Morgane Chrétien,Thomas Freret,Pascale Schumann-Bardet al. 18ème journée de l’Ecole doctorale EdnBISE, Mar 2015, Rouen, France Poster de conférence hal-02436408v1

Brevet (1)

Acetylcholinesterase Inhibitor Compounds and 5ht4 Serotonergic Receptor Agonists, with Promnesia Effect, Methods for the Preparation Thereof and Pharmaceutical Compositions Containing Same Patrick Dallemagne,Christophe Rochais,Cédric Lecoutey,Michel Boulouard,Thomas Freret France, Patent n° : WO2014195593 (A2). 2014 Brevet hal-02042939v1

Pré-publication, Document de travail (1)

Early involvement of D-serine in B-amyloid-dependent pathophysiology Jean-Marie Billard,E. Ploux,Stacy Largilliere,Sophie Corvaisier,Lucie Gorisse-Hussonnoiset al. 2023 Pré-publication, Document de travail hal-04624854v1