Thomas Candela

Maitre de conférences

Documents

Publications

	A Streamlined Method to Obtain Biologically Active TcdA and TcdB Toxins from Clostridioides difficile Diane Sapa , Anaïs Brosse , Héloïse Coullon , Gauthier Péan de Ponfilly , Thomas Candela Toxins, 2024, 16 (1), pp 38. ⟨10.3390/toxins16010038⟩ Journal articles hal-04417180v1
	Spores of Clostridioides difficile are toxin delivery vehicles Carolina Cassona , Sara Ramalhete , Khira Amara , Thomas Candela , Imad Kansau Communications Biology, 2024, 7 (1), pp.839. ⟨10.1038/s42003-024-06521-x⟩ Journal articles hal-04664956v1
	Polysaccharide II Surface Anchoring, the Achilles’ Heel of Clostridioides difficile Jeanne Malet-Villemagne , Liang Yucheng , Laurent Evanno , Sandrine Denis-Quanquin , Jean-Emmanuel Hugonnet Microbiology Spectrum, In press, ⟨10.1128/spectrum.04227-22⟩ Journal articles hal-04009559v1
	The absence of surface D-alanylation, localized on lipoteichoic acid, impacts the Clostridioides difficile way of life and antibiotic resistance Pierre-Alexandre Lacotte , Sandrine Denis-Quanquin , Eva Chatonnat , Julie Le Bris , David Leparfait Frontiers in Microbiology, 2023, 14, ⟨10.3389/fmicb.2023.1267662⟩ Journal articles hal-04281897v1
	Clostridioides difficile peptidoglycan modifications Héloïse Coullon , Thomas Candela Current Opinion in Microbiology, 2022, 65, pp.156-161. ⟨10.1016/j.mib.2021.11.010⟩ Journal articles hal-03933803v1
	Ser/Thr Kinase-Dependent Phosphorylation of the Peptidoglycan Hydrolase CwlA Controls Its Export and Modulates Cell Division in Clostridioides difficile Transito Garcia-Garcia , Sandrine Poncet , Elodie Cuenot , Thibaut Douché , Quentin Giai Gianetto mBio, 2021, 12 (3), pp.e00519-21. ⟨10.1128/mBio.00519-21⟩ Journal articles pasteur-03243540v1
	Peptidoglycan analysis reveals that synergistic deacetylase activity in vegetative Clostridium difficile impacts the host response Héloïse Coullon , Aline Rifflet , Richard Wheeler , Claire Janoir , Ivo G Boneca Journal of Biological Chemistry, 2020, 295 (49), pp.16785-16796. ⟨10.1074/jbc.RA119.012442⟩ Journal articles hal-03332384v1
	Correction: Human IgA bind a diverse array of commensal bacteria Delphine Sterlin , Jehane Fadlallah , Olivia Adams , Claire Fieschi , Christophe Parizot Journal of Experimental Medicine, 2020, 217 (3), ⟨10.1084/jem.2018163501152020c⟩ Journal articles hal-03125222v1
	AsnB is responsible for peptidoglycan precursor amidation in Clostridium difficile in the presence of vancomycin Fariza Ammam , Delphine Patin , Héloïse Coullon , Didier Blanot , Thierry Lambert Microbiology, inPress, 166 (6), ⟨10.1099/mic.0.000917⟩ Journal articles hal-02571416v1
	Human IgA binds a diverse array of commensal bacteria Delphine Sterlin , Jehane Fadlallah , Olivia Adams , Claire Fieschi , Christophe Parizot Journal of Experimental Medicine, 2020, 217 (3), pp.e20181635. ⟨10.1084/jem.20181635⟩ Journal articles hal-02433421v1
	CalY is a major virulence factor and a biofilm matrix protein Thomas Candela , Annette Fagerlund , Christophe Buisson , Nathalie Gilois , Anne‐brit Kolstø Molecular Microbiology, 2019, 111 (6), pp.1416-1429. ⟨10.1111/mmi.14184⟩ Journal articles hal-02620254v2
	The Ser/Thr kinase PrkC participates in cell wall homeostasis and antimicrobial resistance in Clostridium difficile Elodie Cuenot , Transito Garcia-Garcia , Thibaut Douche , Olivier Gorgette , Pascal Courtin Infection and Immunity, 2019, 87 (8), pp.e00005-19. ⟨10.1128/IAI.00005-19⟩ Journal articles pasteur-02164685v1
	Clostridium difficile forms variable biofilms on abiotic surface Véronique Pantaleon , Marc Monot , Catherine Eckert , Sandra Hoys , Anne Collignon Anaerobe, 2018, 53, pp.34-37. ⟨10.1016/j.anaerobe.2018.05.006⟩ Journal articles pasteur-02549240v1
	N-Deacetylases required for muramic-δ-lactam production are involved in Clostridium difficile sporulation, germination, and heat resistance Héloïse Coullon , Aline Rifflet , Richard Wheeler , Claire Janoir , Ivo Gomperts Boneca Journal of Biological Chemistry, 2018, 293 (47), pp.18040-18054. ⟨10.1074/jbc.RA118.004273⟩ Journal articles hal-04374612v1
	Surfaceome and Proteosurfaceome in Parietal Monoderm Bacteria: Focus on Protein Cell-Surface Display Mickaël Desvaux , Thomas Candela , Pascale Serror Frontiers in Microbiology, 2018, 9, ⟨10.3389/fmicb.2018.00100⟩ Journal articles hal-01727158v1
	The Clostridium difficile Protease Cwp84 Modulates both Biofilm Formation and Cell-Surface Properties Véronique Pantaleon , Anna Philibertine Soavelomandroso , Sylvie Bouttier , Romain Briandet , Bryan Roxas PLoS ONE, 2015, 10 (4), ⟨10.1371/journal.pone.0124971⟩ Journal articles hal-02639033v1
	N-acetylglucosamine deacetylases modulate the anchoring of the gamma-glutamyl capsule to the cell wall of Bacillus anthracis. Thomas Candela , Stavroula Balomenou , Willy Aucher , Vassilis Bouriotis , Jean-Pierre Simorre Microbial Drug Resistance, 2014, 20 (3), pp.222-30. ⟨10.1089/mdr.2014.0063⟩ Journal articles hal-01119761v1
	Encapsulated Bacillus anthracis interacts closely with liver endothelium. Alejandro Piris-Gimenez , Jean-Philippe Corre , Gregory Jouvion , Thomas Candela , Huot Khun Journal of Infectious Diseases, 2009, 200 (9), pp.1381-9. ⟨10.1086/644506⟩ Journal articles pasteur-00512101v1
	Edema toxin impairs anthracidal phospholipase A2 expression by alveolar macrophages. Benoît Raymond , Dominique Leduc , Lucas Ravaux , Ronan Le Goffic , Thomas Candela PLoS Pathogens, 2007, 3 (12), pp.e187. ⟨10.1371/journal.ppat.0030187⟩ Journal articles pasteur-00317899v1
	Poly-gamma-glutamate in bacteria. Thomas Candela , Agnès Fouet Molecular Microbiology, 2006, 60 (5), pp.1091-8. ⟨10.1111/j.1365-2958.2006.05179.x⟩ Journal articles pasteur-00317429v1
	CapE, a 47-amino-acid peptide, is necessary for Bacillus anthracis polyglutamate capsule synthesis. Thomas Candela , Michèle Mock , Agnès Fouet Journal of Bacteriology, 2005, 187 (22), pp.7765-72. ⟨10.1128/JB.187.22.7765-7772.2005⟩ Journal articles hal-00082806v1

	A new method to produce TcdA and TcdB toxins from Clostridioides difficile Afi Akofa Diane Sapa , Anaïs Brosse , Héloïse Coullon , Gauthier Péan de Ponfilly , Thomas Candela Réunion Réseau CD France #5, RCDF, Jun 2023, Paris Institut Pasteur, France Conference papers hal-04420506v1
	Le polysaccharide II est essentiel à la mise en place de la surface de C. difficile Jeanne Malet-Villemagne , Léa Huet , Claire Janoir , Isabelle Martin-Verstraete , Thomas Candela Bactéries sporulantes pathogènes ou d'intérêt technologique BSPIT, Nov 2023, Paris, France Conference papers hal-04341988v1
	La D-alanylation de la surface de Clostridioides difficile permet une résistance accrue aux antibiotiques Pierre-Alexandre Lacotte , Sandrine Denis‐quanquin , Isabelle Martin-Verstraete , Thomas Candela SFM, Oct 2022, Montpelier, France Conference papers hal-04341953v1
	Altered spore cortex impairs virulence in C. difficile Héloïse Coullon , Aline Rifflet , Richard Wheeler , Claire Janoir , Ivo Boneca Bactéries Sporulantes Pathogènes ou d'Intérêt Technologique, INRAE, Mar 2018, Paris, France Conference papers hal-04341916v1
	Muramic-δ-lactams are involved in C. difficile sporulation, germination and virulence Héloïse Coullon , Aline Rifflet , Richard Wheeler , Claire Janoir , Ivo Boneca International Clostridium difficile Symposium, Sep 2018, Bled, Slovenia Conference papers hal-04341951v1

	The anchoring of the polysaccharide II is essential for Clostridioides difficile survival Jeanne Malet-Villemagne , Laurent Evanno , Sandrine Denis-Quanquin , Claire Janoir , Thomas Candela Clostpath 13, Sep 2023, Banff (Alberta), France Conference poster hal-04342006v1
	A new method for the production of TcdA and TcdB toxins from Clostridioides difficile Afi Akofa Diane Sapa , Anaïs Brosse , Héloïse Coullon , Gauthier Péan de Ponfilly , Thomas Candela Clostpath 2023, Sep 2023, Banff, Canada Conference poster hal-04342523v1
	A new method for the production of TcdA and TcdB toxins from Clostridioides difficile Alban Le Monnier , Afi Akofa Diane Sapa , Anaïs Brosse , Gauthier Péan de Ponfilly , Thomas Candela ECCMID, Apr 2023, Copenhage, Denmark Conference poster hal-04336412v1
	The absence of surface D-alanylation, localized on lipoteichoic acid, impacts the Clostridioides difficile way of life and antibiotic resistance Pierre-Alexandre Lacotte , Sandrine Denis-Quanquin , Isabelle Martin-Verstraete , Thomas Candela Clostpath 13, Sep 2023, Banff (Alberta), France Conference poster hal-04342019v1
	Nouvelle méthode de production des toxines TcdA et TcdB de Clostridioides difficile Afi Akofa Diane Sapa , Anaïs Brosse , Jeanne Malet-Villemagne , Gauthier Pean De Ponfilly , Alban Le Monnier Microbes 2022, Oct 2022, Montpellier, France Conference poster hal-04336544v1
	Nouvelle méthode de production des toxines TcdA et TcdB de C. difficile Afi Akofa Diane Sapa , Anaïs Brosse , Jeanne Malet-Villemagne , Gauthier Péan de Ponfilly , Thomas Candela MICROBES, Oct 2022, Montpellier, France Conference poster hal-04336498v1
	The anchoring of the polysaccharide II is essential for Clostridioides difficile survival Jeanne Malet-Villemagne , Laurent Evanno , Sandrine Denis‐quanquin , Claire Janoir , Thomas Candela Anaerobe, Jul 2022, Seatle, France Conference poster hal-04341931v1

Thomas Candela

Publications

A Streamlined Method to Obtain Biologically Active TcdA and TcdB Toxins from Clostridioides difficile

Spores of Clostridioides difficile are toxin delivery vehicles

Polysaccharide II Surface Anchoring, the Achilles’ Heel of Clostridioides difficile

The absence of surface D-alanylation, localized on lipoteichoic acid, impacts the Clostridioides difficile way of life and antibiotic resistance

Clostridioides difficile peptidoglycan modifications

Ser/Thr Kinase-Dependent Phosphorylation of the Peptidoglycan Hydrolase CwlA Controls Its Export and Modulates Cell Division in Clostridioides difficile

Peptidoglycan analysis reveals that synergistic deacetylase activity in vegetative Clostridium difficile impacts the host response

Correction: Human IgA bind a diverse array of commensal bacteria

AsnB is responsible for peptidoglycan precursor amidation in Clostridium difficile in the presence of vancomycin

Human IgA binds a diverse array of commensal bacteria

CalY is a major virulence factor and a biofilm matrix protein

The Ser/Thr kinase PrkC participates in cell wall homeostasis and antimicrobial resistance in Clostridium difficile

Clostridium difficile forms variable biofilms on abiotic surface

N-Deacetylases required for muramic-δ-lactam production are involved in Clostridium difficile sporulation, germination, and heat resistance

Surfaceome and Proteosurfaceome in Parietal Monoderm Bacteria: Focus on Protein Cell-Surface Display

The Clostridium difficile Protease Cwp84 Modulates both Biofilm Formation and Cell-Surface Properties

N-acetylglucosamine deacetylases modulate the anchoring of the gamma-glutamyl capsule to the cell wall of Bacillus anthracis.

Encapsulated Bacillus anthracis interacts closely with liver endothelium.

Edema toxin impairs anthracidal phospholipase A2 expression by alveolar macrophages.

Poly-gamma-glutamate in bacteria.

CapE, a 47-amino-acid peptide, is necessary for Bacillus anthracis polyglutamate capsule synthesis.

A new method to produce TcdA and TcdB toxins from Clostridioides difficile

Le polysaccharide II est essentiel à la mise en place de la surface de C. difficile

La D-alanylation de la surface de Clostridioides difficile permet une résistance accrue aux antibiotiques

Altered spore cortex impairs virulence in C. difficile

Muramic-δ-lactams are involved in C. difficile sporulation, germination and virulence

The anchoring of the polysaccharide II is essential for Clostridioides difficile survival

A new method for the production of TcdA and TcdB toxins from Clostridioides difficile

A new method for the production of TcdA and TcdB toxins from Clostridioides difficile

The absence of surface D-alanylation, localized on lipoteichoic acid, impacts the Clostridioides difficile way of life and antibiotic resistance

Nouvelle méthode de production des toxines TcdA et TcdB de Clostridioides difficile

Nouvelle méthode de production des toxines TcdA et TcdB de C. difficile

The anchoring of the polysaccharide II is essential for Clostridioides difficile survival