Thibaut LARCHER Veterinary pathologist

Identifiants chercheurs

IdHAL :

tlarcher

ORCID :

0000-0002-0396-3190

IdRef :

076698297

Présentation

As a veterinary pathologist, I have been in charge since 2007 of the setting up and the development of an academic platform in Nantes, called APEX, dedicated to comparative pathology and animal tissue phenotyping. I have years’ experience in veterinary histopathology, in the identification of tissular biomarkers and in the development of specific labelling and quantitative methods for lesion assessment. I was involved in clinical and pathological evaluation of many animal models (including zebrafish, rodents, pigs, dogs and Non-Human Primates). As a member of the European college of Veterinary pathologist (ECVP), my expertise is recognized by drug regulatory agencies (FDA, EMA). I contributed to preclinical efficacy and safety evaluation of gene and cell therapy protocols (AAV- and muscle-derived stem cell-based ones) and other innovative treatments against viral infectious diseases and tumours for academic and private collaborators. I am the author or co-author of more than 115 articles published in peer-reviewed journals.

Publications

Article dans une revue (113)

MLKL in liver parenchymal cells promotes liver cancer in murine metabolic dysfunction-associated steatotic liver disease Ghiles Imerzoukene,Ghania Hounana Kara-Ali,Celine Heitz-Marchaland,Thibaut Larcher,Mélanie Simoes Eugenioet al. Cell Death and Disease, 2026, 17 (1), pp.229. ⟨10.1038/s41419-026-08458-x⟩ Article dans une revue hal-05538272v1
Dose- and genotype-dependent cardiac arrhythmia and sudden death in rats following microdystrophin gene therapy Caroline Le Guiner,Gilles Toumaniantz,Thibaut Larcher,Sylvie Marchand,Laurine Buscaraet al. Molecular Therapy, 2026, 34 (1), pp.140-160. ⟨10.1016/j.ymthe.2025.10.041⟩ Article dans une revue hal-05466223v1
Swine influenza A virus infection sets the local immunological landscape in subsequent infection with porcine reproductive and respiratory syndrome virus Janaïna Grevelinger,Olivier Bourry,Selma Schmidt,François Meurens,Céline Deblancet al. Veterinary Research, 2025, 56 (1), pp.114. ⟨10.1186/s13567-025-01536-6⟩ Article dans une revue hal-05103379v1
Mini-GRID therapy delivers optimised spatially fractionated radiation therapy using a flattening free filter accelerator M. Isabel Acuña,Charlotte Lamirault,Thibaut Larcher,Elise Brisebard,Tim Schneideret al. Communications Medicine, 2025, 5 (1), pp.101. ⟨10.1038/s43856-025-00809-7⟩ Article dans une revue hal-05263425v1
On the significance of peak dose in normal tissue toxicity in spatially fractionated radiotherapy: The case of proton minibeam radiation therapy Yolanda Prezado,Charlotte Lamirault,Thibaut Larcher,Cristele Gilbert,Julie Espenonet al. Radiotherapy & Oncology, 2025, 205, pp.110769. ⟨10.1016/j.radonc.2025.110769⟩ Article dans une revue hal-05263418v1
Lung infection in orally inoculated SARS-CoV-2 hamsters Evelyne Picard-Meyer,Marine Wasniewski,Franck Boué,Edgar Torres-Maravilla,Vinciane Saint-Criqet al. PLoS ONE, 2025, 20 (12), pp.e0337915. ⟨10.1371/journal.pone.0337915⟩ Article dans une revue hal-05427912v1
Marek’s disease virus replication in chicken skin reconstructed in vitro: evidence for viral particles in corneocytes Laurent Souci,Mélanie Chollot,Katia Courvoisier-Guyader,Julia Lachner,Thibault Kervarrecet al. Journal of General Virology, 2025, 106 (7), pp.2123. ⟨10.1099/jgv.0.002123⟩ Article dans une revue hal-05199574v1
Advancing liver gene therapy: Enhanced transduction with GalNAc-bioconjugated rAAV capsids Pierre-Alban Lalys,Audrey Bourdon,Mohammed Bouzelha,Dimitri Alvarez-Dorta,Karine Pavageauet al. Biomedicine and Pharmacotherapy, 2025, 189, pp.118300. ⟨10.1016/j.biopha.2025.118300⟩ Article dans une revue hal-05263420v1
Dose Heterogeneity Reduces Radiation Oxygen Dependence in Both Tumor and Healthy Tissues: The Case of Proton Minibeam Radiation Therapy Sarah Potiron,Lorea Iturri,Charlotte Lamirault,Morgane Dos Santos,Angela Corvinoet al. International Journal of Radiation Oncology, Biology, Physics, 2025, 123 (4), pp.1132-1145. ⟨10.1016/j.ijrobp.2025.06.3859⟩ Article dans une revue hal-05237036v1
Sphingolipids in Extracellular Vesicles Released From the Skeletal Muscle Plasma Membrane Control Muscle Stem Cell Fate During Muscle Regeneration Rhyma Hakkar,Caroline E Brun,Pascal Leblanc,Emmanuelle Meugnier,Emmanuelle Berger‐dantyet al. Journal of Extracellular Vesicles, 2025, 14 (9), ⟨10.1002/jev2.70164⟩ Article dans une revue hal-05292865v1
Multiscale physiological responses to organic and inorganic pollution in the invasive mosquitofish Gambusia holbrooki Nicolas Martin,Simon Blanchet,Sophie Hermet,Thibaut Larcher,Romain Groset al. Ecotoxicology and Environmental Safety, 2025, 302, pp.118565. ⟨10.1016/j.ecoenv.2025.118565⟩ Article dans une revue hal-05167049v1
MEK inhibition prevents human skin graft rejection by promoting CD8+TCF1+ over CD8 effector T cells Christine Chauveau,Veronique Nerriere-Daguin,Maeva Fourny,Cynthia Fourgeux,Thibaut Larcheret al. iScience, 2025, 28 (9), pp.113310. ⟨10.1016/j.isci.2025.113310⟩ Article dans une revue hal-05263430v1
The prion-family protein Doppel exerts a protective role during influenza virus infection Soraya Dinant,Johan Castille,Charlotte Deloizy,Elise Bruder,Laura Sedanoet al. Journal of Immunology, 2025, pp.1-13. ⟨10.1093/jimmun/vkaf031⟩ Article dans une revue hal-05029118v1
Novel chemical tyrosine functionalization of adeno-associated virus improves gene transfer efficiency in liver and retina Aurélien Leray,Pierre-Alban Lalys,Juliette Varin,Mohammed Bouzelha,Audrey Bourdonet al. Biomedicine and Pharmacotherapy, 2024, 171, pp.116148. ⟨10.1016/j.biopha.2024.116148⟩ Article dans une revue hal-04781485v1
Characterisation of a Japanese Encephalitis virus genotype 4 isolate from the 2022 Australian outbreak Wilson Nguyen,Narayan Gyawali,Romal Stewart,Bing Tang,Abigail L. Coxet al. npj Viruses, 2024, 2 (1), pp.15. ⟨10.1038/s44298-024-00025-5⟩ Article dans une revue hal-04597740v1
Omega-3 Fatty Acid and Vitamin D Supplementations Partially Reversed Metabolic Disorders and Restored Gut Microbiota in Obese Wistar Rats Dylan Le Jan,Mohamed Siliman Misha,Sandrine Destrumelle,Olivia Terceve,Chantal Thorinet al. Biology, 2024, 13 (12), pp.1070. ⟨10.3390/biology13121070⟩ Article dans une revue hal-04996002v1
Drug repurposing screen identifies lonafarnib as respiratory syncytial virus fusion protein inhibitor Svenja Sake,Xiaoyu Zhang,Manoj Kumar Rajak,Melanie Urbanek-Quaing,Arnaud Carpentieret al. Nature Communications, 2024, 15 (1), pp.1173. ⟨10.1038/s41467-024-45241-y⟩ Article dans une revue hal-04504093v1
The caecal microbiota promotes the acute inflammatory response and the loss of the intestinal barrier integrity during severe Eimeria tenella infection Florian Tomal,Guillaume Sadrin,Pauline Gaboriaud,Edouard Guitton,Laura Sedanoet al. Frontiers in Cellular and Infection Microbiology, 2023, 13, pp.1250080. ⟨10.3389/fcimb.2023.1250080⟩ Article dans une revue hal-04187670v1
Homologous recombination deficiency derived from whole-genome sequencing predicts platinum response in triple-negative breast cancers Petra ter Brugge,Sarah Moser,Ivan Bièche,Petra Kristel,Sabrina Ibadiouneet al. Nature Communications, 2023, 14 (1), pp.1958. ⟨10.1038/s41467-023-37537-2⟩ Article dans une revue hal-04072477v1
Oxidative phosphorylation is a metabolic vulnerability of endocrine therapy and palbociclib resistant metastatic breast cancers Rania El-Botty,Ludivine Morriset,Elodie Montaudon,Zakia Tariq,Anne Schnitzleret al. Nature Communications, 2023, 14 (1), pp.4221. ⟨10.1038/s41467-023-40022-5⟩ Article dans une revue hal-04205847v1
Recurrence and survival in dogs with excised colorectal polyps: A retrospective study of 58 cases Tristan Méric,Julien Issard,Thomas Maufras,Marine Hugonnard,Odile Senecatet al. Journal of Veterinary Internal Medicine, 2023, 37 (6), pp.2375-2384. ⟨10.1111/jvim.16876⟩ Article dans une revue hal-04234504v1
Myopathy with oval inclusions in a domestic shorthair cat Eliot Gougeon,Thibaut Larcher,Mireille Ledevin,Yvonne Mcgrotty,Pierre Méheust Journal of Feline Medicine and Surgery Open Reports, 2022, 8 (1), pp.205511692210814. ⟨10.1177/20551169221081418⟩ Article dans une revue hal-03620285v1
Evaluation of the dystrophin carboxy-terminal domain for micro-dystrophin gene therapy in cardiac and skeletal muscles in the DMDmdx rat model Audrey Bourdon,Virginie François,Liwen Zhang,Aude Lafoux,Bodvael Fraysseet al. Gene Therapy, 2022, 29 (9), pp.520-535. ⟨10.1038/s41434-022-00317-6⟩ Article dans une revue hal-03838616v1
Receptor-interacting protein kinase-1 ablation in liver parenchymal cells promotes liver fibrosis in murine NASH without affecting other symptoms Muhammad Farooq,Melanie Simoes Eugenio,Claire Piquet-Pellorce,Sarah Dion,Celine Raguenes-Nicolet al. Journal of Molecular Medicine, 2022, 100 (7), pp.1027-1038. ⟨10.1007/s00109-022-02192-5⟩ Article dans une revue hal-03711624v1
Palmitic acid conjugation enhances potency of tricyclo-DNA splice switching oligonucleotides Karima Relizani,Lucía Echevarría,Faouzi Zarrouki,Cécile Gastaldi,Chloe Dambruneet al. Nucleic Acids Research, 2022, 50 (1), pp.:17-34. ⟨10.1093/nar/gkab1199⟩ Article dans une revue hal-03476811v1
Receptor‑interacting protein kinase‑1 ablation in liver parenchymal cells promotes liver fibrosis in murine NASH without affecting other symptoms Muhammad Akmal Farooq,Melanie Simoes Eugenio,Claire Picquet-Pellorce,Sarah Dion,Céline Raguénès-Nicolet al. Journal of Molecular Medicine, 2022 Article dans une revue hal-03635249v1
In vivo imaging reveals novel replication sites of a highly oncogenic avian herpesvirus in chickens Isabelle Lantier,Corentin Mallet,Laurent Souci,Thibaut Larcher,Andele Conradieet al. PLoS Pathogens, 2022, 18 (8), 28 p. ⟨10.1371/journal.ppat.1010745⟩ Article dans une revue hal-03775131v1
Effects of metals and persistent organic pollutants on the fitness and health of juveniles of the endangered European sturgeon Acipenser sturio exposed to water and sediments of the Garonne and Dordogne rivers J. Lucas,C. Lefrancois,Charline Gesset,H. Budzinski,P. Labadieet al. Ecotoxicology and Environmental Safety, 2021, 225, pp.112720. ⟨10.1016/j.ecoenv.2021.112720⟩ Article dans une revue hal-03373747v1
New Look at RSV Infection: Tissue Clearing and 3D Imaging of the Entire Mouse Lung at Cellular Resolution Maxence Frétaud,Delphyne Descamps,Daphné Laubret,Marie-Anne Rameix-Welti,Jean-François Eléouëtet al. Viruses, 2021, 13 (2), pp.201. ⟨10.3390/v13020201⟩ Article dans une revue hal-03159667v1
Direct and indirect effects of multiple environmental stressors on fish health in human-altered rivers Quentin Petitjean,Séverine Jean,Jessica Côte,Thibaut Larcher,Frédéric Angelieret al. Science of the Total Environment, 2020, 742, pp.140657. ⟨10.1016/j.scitotenv.2020.140657⟩ Article dans une revue hal-02898178v1
Oxythermal window drastically constraints the survival and development of European sturgeon early life phases Nicolas Delage,Blandine Couturier,Philippe Jatteau,Thibaut Larcher,Mireille Ledevinet al. Environmental Science and Pollution Research, 2020, 27, ⟨10.1007/s11356-018-4021-8⟩ Article dans une revue hal-02091624v1
The Absence of Gut Microbiota Alters the Development of the Apicomplexan Parasite Eimeria tenella Pauline Gaboriaud,Guillaume Sadrin,Edouard Guitton,Geneviève Fort,Alisson Niepceronet al. Frontiers in Cellular and Infection Microbiology, 2020, 10, pp.632556. ⟨10.3389/fcimb.2020.632556⟩ Article dans une revue hal-03156323v1
A Yellow Fever Virus 17D Infection and Disease Mouse Model Used to Evaluate a Chimeric Binjari-Yellow Fever Virus Vaccine Kexin Yan,Laura J Vet,Bing Tang,Jody Hobson-Peters,Daniel J Rawleet al. Vaccines 2020, 2020, 8, ⟨10.3390/vaccines8030368⟩ Article dans une revue hal-02898172v1
Characterization of brain dystrophins absence and impact in dystrophin-deficient Dmdmdx rat model Dorian Caudal,Virginie François,Aude Lafoux,Mireille Ledevin,Ignacio Anegonet al. PLoS ONE, 2020, 15 (3), pp.e0230083. ⟨10.1371/journal.pone.0230083⟩ Article dans une revue hal-02509545v1
Targeting the Respiratory Syncytial Virus N 0 -P Complex with Constrained α-Helical Peptides in Cells and Mice Marie Galloux,Nadège Gsponer,Vanessa Gaillard,Brice Fenner,Thibaut Larcheret al. Antimicrobial Agents and Chemotherapy, 2020, 64 (10), ⟨10.1128/AAC.00717-20⟩ Article dans une revue hal-03353101v1
PCV2 co-infection does not impact PRRSV MLV1 safety but enhances virulence of a PRRSV MLV1-like strain in infected SPF pigs Julie Eclercy,Thibaut Larcher,Mathieu Andraud,Patricia Renson,Cécilia Bernardet al. Veterinary Microbiology, 2020, 244, pp.108656. ⟨10.1016/j.vetmic.2020.108656⟩ Article dans une revue hal-02561973v1
Intra-CSF AAV9 and AAVrh10 Administration in Nonhuman Primates: Promising Routes and Vectors for Which Neurological Diseases? Karim Bey,Johan Deniaud,Laurence Dubreil,Béatrice Joussemet,Joseph Cristiniet al. Molecular Therapy - Methods and Clinical Development, 2020, 17, pp.771-784. ⟨10.1016/j.omtm.2020.04.001⟩ Article dans une revue hal-02561949v2
PLK1 inhibition exhibits strong anti-tumoral activity in CCND1-driven breast cancer metastases with acquired palbociclib resistance Elodie Montaudon,Joanna Nikitorowicz-Buniak,Laura Sourd,Ludivine Morisset,Rania El Bottyet al. Nature Communications, 2020, 11, ⟨10.1038/s41467-020-17697-1⟩ Article dans une revue hal-02933439v1
BRCAness, SLFN11, and RB1 loss predict response to topoisomerase I inhibitors in triple-negative breast cancers Florence Coussy,Rania El-Botty,Sophie Château-Joubert,Ahmed Dahmani,Elodie Montaudonet al. Science Translational Medicine, 2020, 12 (531), pp.eaax2625. ⟨10.1126/scitranslmed.aax2625⟩ Article dans une revue hal-02508765v1
Combination of PI3K and MEK inhibitors yields durable remission in PDX models of PIK3CA-mutated metaplastic breast cancers F. Coussy,R. El Botty,M. Lavigne,C. Gu,L. Fuhrmannet al. Journal of Hematology and Oncology, 2020, 13 (1), ⟨10.1186/s13045-020-0846-y⟩ Article dans une revue hal-02508763v1
Response to mTOR and PI3K inhibitors in enzalutamide-resistant luminal androgen receptor triple-negative breast cancer patient-derived xenografts Florence Coussy,Marion Lavigne,Leanne de Koning,Rania El Botty,Fariba Nematiet al. Theranostics, 2020, 10 (4), pp.1531-1543. ⟨10.7150/thno.36182⟩ Article dans une revue hal-02509541v1
Assessment of pulmonary tissue responses in pigs challenged with PRRSV Lena strain shows better protection after immunization with field than vaccine strains Thibaut Larcher,Christelle Fablet,Patricia Renson,Déborah Menard,Caroline Hervetet al. Veterinary Microbiology, 2019, 230, pp.249-259. ⟨10.1016/j.vetmic.2019.01.022⟩ Article dans une revue hal-02061157v1
Immunophenotype of a Rat Model of Duchenne's Disease and Demonstration of Improved Muscle Strength After Anti-CD45RC Antibody Treatment Laure-Hélène Ouisse,Severine Remy,Aude Lafoux,Thibaut Larcher,Laurent Tessonet al. Frontiers in Immunology, 2019, 10, ⟨10.3389/fimmu.2019.02131⟩ Article dans une revue inserm-02341819v1
5 years of successful inducible transgene expression following locoregional AAV delivery in nonhuman primates with no detectable immunity Mickael Guilbaud,Marie Devaux,Célia Couzinié,Johanne Le Duff,Alice Toromanoffet al. Human Gene Therapy, 2019, ⟨10.1089/hum.2018.234⟩ Article dans une revue hal-02091623v1
Macrophage-B Cell Interactions in the Inverted Porcine Lymph Node and Their Response to Porcine Reproductive and Respiratory Syndrome Virus Elise Bordet,Maxence Fretaud,Elisa Crisci,Edwige Bouguyon,Stephane Raultet al. Frontiers in Immunology, 2019, 10, pp.953. ⟨10.3389/fimmu.2019.00953⟩ Article dans une revue hal-02164040v1
A large collection of integrated genomically characterized patient‐derived xenografts highlighting the heterogeneity of triple‐negative breast cancer Florence Coussy,Leanne Koning,Marion Lavigne,Virginie Bernard,Berengere Ouineet al. International Journal of Cancer, 2019, ⟨10.1002/ijc.32266⟩ Article dans une revue hal-02093370v1
VEGF-A inhibition as a potential therapeutic approach in Merkel cell carcinoma Thibault Kervarrec,Pauline Gaboriaud,A. Tallet,Valérie Leblond,Françoise Arnoldet al. Journal of Investigative Dermatology, 2019, 139 (3), pp.736-739. ⟨10.1016/j.jid.2018.08.029⟩ Article dans une revue hal-02621891v1
5 years of successful inducible transgene expression following locoregional AAV delivery in nonhuman primates with no detectable immunity Mickaël Guilbaud,Marie Devaux,Célia Couzinié,Johanne Le Duff,Alice Toromanoffet al. Human Gene Therapy, 2019 Article dans une revue inserm-02052292v1
Exacerbation of Chikungunya Virus Rheumatic Immunopathology by a High Fiber Diet and Butyrate Natalie Prow,Thiago Hirata,Bing Tang,Thibaut T. Larcher,Pamela Mukhopadhyayet al. Frontiers in Immunology, 2019, 10, ⟨10.3389/fimmu.2019.02736⟩ Article dans une revue hal-02885399v1
fixation et inclusion en paraffine de tissus d'abeille pour une observation histologique Mireille Ledevin,Monique L'Hostis,Thibaut Larcher Revue Française d'Histotechnologie, 2018, 30 (1), pp.17-30 Article dans une revue hal-01867045v1
Atrophy of primary lymphoid organs induced by Marek's disease virus during early infection is associated with increased apoptosis, inhibition of cell proliferation and a severe B-lymphopenia Camille Berthault,Thibaut Larcher,Sonja Härtle,Jean-François Vautherot,Laëtitia Trapp-Fragnetet al. Veterinary Research, 2018, 49 (1), pp.1-18. ⟨10.1186/s13567-018-0526-x⟩ Article dans une revue hal-02628278v1
Satellite cells fail to contribute to muscle repair but are functional in Pompe disease (glycogenosis type II). Lydie Lagalice,Julien Pichon,Eliot Gougeon,Salwa Soussi,Johan Deniaudet al. Acta Neuropathologica Communications, 2018, 6 (1), pp.116. ⟨10.1186/s40478-018-0609-y⟩ Article dans une revue hal-02623544v1
Exploring multiple effects of Zn0.15Mg0.85O nanoparticles on Bacillus subtilis and macrophages Sandrine Auger,Céline Henry,Christine Longin,Sneha Suman,Nathalie Lejalet al. Scientific Reports, 2018, 8 (1), ⟨10.1038/s41598-018-30719-9⟩ Article dans une revue hal-01867036v1
Major contribution of the RNA-binding domain of NS1 in the pathogenicity and replication potential of an avian H7N1 influenza virus in chickens Sascha Trapp,Denis Soubieux,Alexandra Lidove,Evelyne Esnault,Adrien Lionet al. Virology Journal, 2018, 15, pp.1-12. ⟨10.1186/s12985-018-0960-4⟩ Article dans une revue hal-02626011v1
Vascular Delivery of Allogeneic MuStem Cells in Dystrophic Dogs Requires Only Short-Term Immunosuppression to Avoid Host Immunity and Generate Clinical/Tissue Benefits Judith Lorant,Thibaut Larcher,Nicolas Jaulin,Benoit Hedan,Aurélie Lardenoiset al. Cell Transplantation, 2018, 27 (7), pp.1096-1110. ⟨10.1177/0963689718776306⟩ Article dans une revue hal-01812518v1
Long-term microdystrophin gene therapy is effective in a canine model of Duchenne muscular dystrophy Caroline C. Le Guiner,Laurent Servais,Marie Montus,Thibaut Thibaut,Bodvael Fraysseet al. Nature Communications, 2017, 8 (1), pp.16105. ⟨10.1038/ncomms16105⟩ Article dans une revue hal-02179396v1
A short double-stapled peptide inhibits respiratory syncytial virus entry and spreading Vanessa Gaillard,Marie Galloux,Dominique Garcin,Jean Francois Eleouet,Ronan Le Gofficet al. Antimicrobial Agents and Chemotherapy, 2017, 61 (4), ⟨10.1128/AAC.02241-16⟩ Article dans une revue hal-01605887v1
Epicutaneous Tolerance Induction to a Bystander Antigen Abrogates Colitis and Ileitis in Mice David Dunkin,M. Cecilia Berin,Lucie Mondoulet,Steven Tobar,Garabet Yeretssianet al. Inflammatory Bowel Diseases, 2017, 23 (11), pp.1972-1982. ⟨10.1097/MIB.0000000000001273⟩ Article dans une revue hal-01701599v1
Characterisation of Early-Life Fecal Microbiota in Susceptible and Healthy Pigs to Post-Weaning Diarrhoea Samir Dou,Pascale Gadonna-Widehem,Véronique Rome,Dounia Hamoudi,Larbi Rhaziet al. PLoS ONE, 2017, 12 (1), pp.e0169851. ⟨10.1371/journal.pone.0169851⟩ Article dans une revue hal-01525331v1
Treatment of gastric eosinophilia by epicutaneous immunotherapy in piglets sensitized to peanuts L. Mondoulet,N. Kalach,V. Dhelft,Thibaut Larcher,C. Delayre-Orthezet al. Clinical and Experimental Allergy, 2017, 47 (12), pp.1640-1647. ⟨10.1111/cea.13037⟩ Article dans une revue hal-01701597v1
Fish Reproduction Is Disrupted upon Lifelong Exposure to Environmental PAHs Fractions Revealing Different Modes of Action Caroline Vignet,Thibaut Larcher,Blandine Davail,Lucette Joassard,Karyn Le Menachet al. Toxics, 2016, 4 (4), pp.26. ⟨10.3390/toxics4040026⟩ Article dans une revue hal-01425791v1
Identification in GRMD dog muscle of critical miRNAs involved in pathophysiology and effects associated with MuStem cell transplantation. Florence Robriquet,Candice Babarit,Thibaut Larcher,Laurence Dubreil,Mireille Ledevinet al. BMC Musculoskeletal Disorders, 2016, 17 (1), pp.209. ⟨10.1186/s12891-016-1060-5⟩ Article dans une revue hal-01321085v1
Antioxidant properties of formula derived Maillard reaction products in colons of intrauterine growth restricted pigs Ghada Elmhiri,Dounia Hamoudi,Samir Dou,Narges Bahi-Jaber,Julie Reygnieret al. Food and Function, 2016, 7 (6), ⟨10.1039/c5fo01551k⟩ Article dans une revue hal-01310596v1
Non-invasive epicutaneous vaccine against Respiratory Syncytial Virus: Preclinical proof of concept Pierre-Louis Hervé,Delphyne Descamps,Charlotte Deloizy,Véronique Dhelft,Daphné Laubretonet al. Journal of Controlled Release, 2016, 243, pp.146-159. ⟨10.1016/j.jconrel.2016.10.003⟩ Article dans une revue hal-01425790v1
Altered DNA methylation associated with an abnormal liver phenotype in a cattle model with a high incidence of perinatal pathologies Hélène Kiefer,Luc Jouneau,Evelyne E. Campion,Delphine Rousseau-Ralliard,Thibaut Larcheret al. Scientific Reports, 2016, 6, pp.38869. ⟨10.1038/srep38869⟩ Article dans une revue hal-02633915v1
Treatment of colitis by epicutaneous immunotherapy in a murine model David Dunkin,M Cecilia Berin,Lucie Mondoulet,Zaruhi Hovhannisyan,Alina Iugaet al. Inflammatory Bowel Diseases, 2016, 22, pp.S5. ⟨10.1097/01.MIB.0000480100.25518.df⟩ Article dans une revue hal-01594622v1
Quantitative proteome profiling of dystrophic dog skeletal muscle reveals a stabilized muscular architecture and protection against oxidative stress after systemic delivery of MuStem cells. Aurélie Lardenois,Sabrina Jagot,Mélanie Lagarrigue,Blandine Guével,Mireille Ledevinet al. Proteomics, 2016, 16 (14), pp.2028-2042. ⟨10.1002/pmic.201600002⟩ Article dans une revue hal-01332030v1
Formula-derived advanced glycation end products are involved in the development of long-term inflammation and oxidative stress in kidney of IUGR piglets. Ghada Elmhiri,Dler F D Mahmood,Celine Niquet-Leridon,Philippe Jacolot,Stéphane Firminet al. Molecular Nutrition and Food Research, 2015, 59 (5), ⟨10.1002/mnfr.201400722⟩ Article dans une revue istex hal-01140160v1
Application of texture analysis to muscle MRI: 1- What kind of information should be expected from texture analysis? Jacques D. de Certaines,Thibaut Larcher,Dorota Duda,Noura Azzabou,Pierre-Antoine Eliatet al. European Physical Journal: Applied Physics, 2015, 3 (3), pp.3. ⟨10.1140/s40366-015-0017-1⟩ Article dans une revue hal-01140159v1
Early Interaction of Adeno-Associated Virus Serotype 8 Vector with the Host Immune System Following Intramuscular Delivery Results in Weak but Detectable Lymphocyte and Dendritic Cell Transduction Gwladys Gernoux,Mickaël Guilbaud,Laurence Dubreil,Thibaut Larcher,Candice Babaritet al. Human Gene Therapy, 2015, 26 (1), pp.1 - 13. ⟨10.1089/hum.2014.070⟩ Article dans une revue inserm-01734763v1
Infectious chikungunya virus in the saliva of mice, monkeys and humans Joy Gardner,Penny A. Rudd,Natalie A Prow,Essia Belarbi,Pierre Roqueset al. PLoS ONE, 2015, 10 (10), ⟨10.1371/journal.pone.0139481⟩ Article dans une revue hal-01205627v1
Differential Gene Expression Profiling of Dystrophic Dog Muscle after MuStem Cell Transplantation Florence Robriquet,Aurélie Lardenois,Candice Babarit,Thibaut Larcher,Laurence Dubreilet al. PLoS ONE, 2015, 10 (5), ⟨10.1371/journal.pone.0123336⟩ Article dans une revue hal-01222898v1
MRI texture analysis of GRMD dogs using orthogonal moments : a preliminary study. G Yang,V Lalande,L Chen,N. Azzabou,Thibaut Larcheret al. Innovation and Research in BioMedical engineering, 2015, 36 (4), pp.213-219. ⟨10.1016/j.irbm.2015.06.004⟩ Article dans une revue hal-01180288v1
Application of texture analysis to muscle MRI: 1-What kind of information should be expected from texture analysis? Jacques D de Certaines,Thibaut Larcher,Dorota Duda,Noura Azzabou,Pierre-Antoine Eliatet al. EPJ Nonlinear Biomedical Physics, 2015, 3 (1), pp.1-14. ⟨10.1140/epjnbp/s40366-015-0017-1⟩ Article dans une revue hal-01306718v1
Short-lived recombinant adeno-associated virus transgene expression in dystrophic muscle is associated with oxidative damage to transgene mRNA Jean-Baptiste Dupont,Benoit Tournaire,Christophe Georger,Béatrice Marolleau,Laurence Jeanson-Lehet al. Molecular Therapy - Methods and Clinical Development, 2015, 27 (3), pp.122-34. ⟨10.1038/mtm.2015.10⟩ Article dans une revue inserm-01799048v1
In vivo evaluation of cervical stiffness evolution during induced ripening using shear wave elastography, histology and 2 photon excitation microscopy: Insight from an animal model L. Peralta,Eve Mourier,Christophe Richard,Gilles Charpigny,Thibaut Larcheret al. PLoS ONE, 2015, 10 (8), pp.1-21. ⟨10.1371/journal.pone.0133377⟩ Article dans une revue hal-01194173v1
Forelimb Treatment in a Large Cohort of Dystrophic Dogs Supports Delivery of a Recombinant AAV for Exon Skipping in Duchenne Patients Caroline Le Guiner,Marie Montus,Laurent Servais,Yan Cherel,Virginie Françoiset al. Molecular Therapy, 2014, 22 (11), pp.1923-1935. ⟨10.1038/mt.2014.151⟩ Article dans une revue inserm-02447482v1
Multiple immune factors are involved in controlling acute and chronic chikungunya virus infection Yee Suan Poo,Penny A. Rudd,Joy Gardner,Jane A. C. Wilson,Thibaut T. Larcheret al. PLoS Neglected Tropical Diseases, 2014, 8 (12), ⟨10.1371/journal.pntd.0003354⟩ Article dans une revue hal-02633819v1
Characterization of Dystrophin Deficient Rats: A New Model for Duchenne Muscular Dystrophy Thibaut Larcher,Aude Lafoux,Laurent Tesson,Severine Remy,Virginie Thepenieret al. PLoS ONE, 2014, 9 (10), 13 p. ⟨10.1371/journal.pone.0110371⟩ Article dans une revue hal-01190124v1
CCR2 deficiency promotes exacerbated chronic erosive neutrophil-dominated chikungunya virus arthritis Yee Suan Poo,Helder Nakaya,Joy Gardner,Thibaut Larcher,Wayne Schroderet al. Journal of Virology, 2014, 88 (12), pp.6862-6872. ⟨10.1128/JVI.03364-13⟩ Article dans une revue hal-01222894v1
UCP1 is present in porcine adipose tissue and is responsive to postnatal leptin Alison Mostyn,Linda Attig,Thibaut T. Larcher,Samir Dou,Pascale Chavatte-Palmeret al. Journal of Endocrinology, 2014, 223 (1), pp.M31-M38. ⟨10.1530/JOE-14-0155⟩ Article dans une revue hal-02632643v1
Chronic dietary exposure of zebrafish to PAH mixtures results in carcinogenic but not genotoxic effects Thibaut Larcher,P. Perrichon,Caroline Vignet,Mireille Ledevin,K. Le Menachet al. Environmental Science and Pollution Research, 2014, 21 (24), pp.13833-13849. ⟨10.1007/s11356-014-2923-7⟩ Article dans une revue hal-01123338v1
Comparison of the effects of the dietary addition of two lactic acid bacteria on the development and conformation of sea bass larvae, Dicentrarchus labrax, and the influence on associated microbiota. Faouzi Lamari,Mathieu Castex,Thibaut T. Larcher,Mireille Ledevin,David Mazuraiset al. Aquaculture, 2013, 376-379, pp.137-145. ⟨10.1016/j.aquaculture.2012.11.016⟩ Article dans une revue hal-02645134v1
Deletion of the C-terminal ESEV domain of NS1 does not affect the replication of a low-pathogenic avian influenza virus H7N1 in ducks and chickens Sebastien Mathieu Soubies,Thomas Hoffmann,Guillaume Croville,Thibaut T. Larcher,Mireille Ledevinet al. Journal of General Virology, 2013, 94 (1), pp.50-58. ⟨10.1099/vir.0.045153-0⟩ Article dans une revue hal-02648076v1
Effect of Experimental Infection with Haemonchus contortus on Parasitological and Local Cellular Responses in Resistant and Susceptible Young Creole Goats Jean-Christophe Bambou,Thibaut T. Larcher,Willy W. Cei,Pierre-Justin Dumoulin,Nathalie Mandonnet BioMed Research International , 2013, pp.1-9. ⟨10.1155/2013/902759⟩ Article dans une revue hal-02644024v1
Postnatal leptin promotes organ maturation and development in IUGR piglets Linda Attig,Daphné Brisard,Thibaut Larcher,Michal Mickiewicz,Paul Guilloteauet al. PLoS ONE, 2013, 8 (5), ⟨10.1371/journal.pone.0064616⟩ Article dans une revue hal-01136703v2
Dietary lipid and cholesterol induce ovarian dysfunction and abnormal LH response to stimulation in rabbits Anne Gaël Cordier,Pauline Leveille,Charlotte Dupont,Anne Couturier-Tarrade,Olivier Piconeet al. PLoS ONE, 2013, 8 (5), pp.1-11. ⟨10.1371/journal.pone.0063101⟩ Article dans une revue hal-01004078v1
Variation patterns in individual fish responses to chemical stress among estuaries, seasons and genders: the case of the European flounder (Platichthys flesus) in the Bay of Biscay Jean Laroche,Olivier Gauthier,Louis Quiniou,Alain Devaux,Sylvie Bonyet al. Environmental Science and Pollution Research, 2013, 20 (2), pp.738-48. ⟨10.1007/s11356-012-1276-3⟩ Article dans une revue istex halsde-00786498v1
Histopathological lesions and DNA adducts in the liver of European flounder (&lt;em&gt;Platichthys flesus&lt;/em&gt;) collected in the Seine estuary versus two reference estuarine systems on the French Atlantic coast Jerome Cachot,Yan Cherel,Thibaut T. Larcher,Annie Pfohl-Leszkowicz,Jean Larocheet al. Environmental Science and Pollution Research, 2013, 20 (2), pp.723 - 737. ⟨10.1007/s11356-012-1287-0⟩ Article dans une revue hal-02644574v1
Validation of BdCCp2 as a marker for Babesia divergens sexual stages in ticks Claire Becker,Laurence Malandrin,Thibaut T. Larcher,Alain Chauvin,Emmanuel Bischoffet al. Experimental Parasitology, 2013, 133 (1), pp.51-56. ⟨10.1016/j.exppara.2012.10.007⟩ Article dans une revue hal-02642668v1
Interferon response factors 3 and 7 protect against Chikungunya virus hemorrhagic fever and shock Penny A Rudd,Jane Wilson,Joy Gardner,Thibaut Larcher,Candice Babaritet al. Journal of Virology, 2012, 86, pp.9888-9898. ⟨10.1128/JVI.00956-12⟩ Article dans une revue hal-01191139v1
Porcine colon explants in the study of innate immune response to Entamoeba histolytica Fabienne Girard-Misguich,Mario Delgado-Ortega,Patricia Berthon,Christelle Rossignol,Thibaut T. Larcheret al. Veterinary Immunology and Immunopathology, 2012, 145 (3-4), pp.611-617. ⟨10.1016/j.vetimm.2012.01.002⟩ Article dans une revue istex hal-02650556v1
Epicutaneous Immunotherapy (EPIT) blocks the allergic esophago-gastro -enteropathy induced by sustaines oral exposure to peanuts in sensitized mice Lucie Mondoulet,Vincent Dioszeghy,Thibaut T. Larcher,Mélanie Ligouis,Véronique Dhelftet al. PLoS ONE, 2012, 7 (2), pp.e31967. ⟨10.1371/journal.pone.0031967⟩ Article dans une revue hal-02652477v1
Ingenol mebutate field-directed treatment of UVB damaged skin reduces lesion formation and removes mutant p53 patches Sarah-Jane Cozzi,Steven M. Ogbourne,Cini James,Heggert G. Rebel,Frank R. de Gruijlet al. Journal of Investigative Dermatology, 2012, 132 (4), pp.1263-1271. ⟨10.1038/jid.2011.418⟩ Article dans une revue hal-02648779v1
CELL THERAPY OF DUCHENNE MUSCULAR DYSTROPHY: PRECLINICAL TRIAL IN GRMD DOGS Yan Cherel,Karl Rouger,Thibaut T. Larcher,Laurence Dubreil,Jack-Yves Deschampset al. Bulletin de l'Académie Vétérinaire de France, 2011, 164 (3), pp.211 - 216 Article dans une revue hal-02647422v1
Systemic delivery of allogenic muscle stem cells induces long-term muscle repair and clinical efficacy in duchenne muscular dystrophy dogs. Karl Rouger,Thibaut Larcher,Laurence Dubreil,Jack-Yves Deschamps,Caroline Le Guineret al. American Journal of Pathology, 2011, 179 (5), pp.2501-18. ⟨10.1016/j.ajpath.2011.07.022⟩ Article dans une revue inserm-00712818v1
Long-term food-exposure of zebrafish to PCB mixtures mimicking some environmental situations induces ovary pathology and impairs reproduction ability Tarek Daouk,Thibaut Larcher,François Roupsard,Laura Lyphout,Cyril Rigaudet al. Aquatic Toxicology, 2011, 105, pp.270-278. ⟨10.1016/j.aquatox.2011.06.021⟩ Article dans une revue hal-01205024v1
Towards the establishment of a porcine model to study human amebiasis. Fabienne Girard-Misguich,Juliette Cognie,Mario Delgado-Ortega,Patricia Berthon,Christelle Rossignolet al. PLoS ONE, 2011, 6 (12), ⟨10.1371/journal.pone.0028795⟩ Article dans une revue hal-01129611v1
A novel chicken lung epithelial cell line: Characterization and response to low pathogenicity avian influenza virus Evelyne Esnault,Claire Bonsergent,Thibaut Larcher,Bertrand Bed'Hom,Jean-François Vautherotet al. Virus Research, 2011, 159 (1), pp.32-42. ⟨10.1016/j.virusres.2011.04.022⟩ Article dans une revue hal-01129500v1
Postnatal leptin is necessary for maturation of numerous organs in newborn rats Linda L. Attig,Thibaut T. Larcher,Arieh Gertler,Latifa Abdennebi- Najar,Jean Djiane Organogenesis, 2011, 7 (2), pp.88-94. ⟨10.4161/org.7.2.14871⟩ Article dans une revue hal-02643082v1
A genetically engineered waterfowl influenza virus with a deletion in the stalk of the neuraminidase has increased virulence for chickens S. Munier,Thibaut T. Larcher,Fleur Cormier-Aline,Denis Soubieux,B. Suet al. Journal of Virology, 2010, 84 (2), pp.940-952. ⟨10.1128/JVI.01581-09⟩ Article dans une revue hal-02662785v1
Chikungunya virus arthritis in adult wild-type mice Joy Gardner,Itaru Anraku,Thuy T. Le,Thibaut T. Larcher,Lee Majoret al. Journal of Virology, 2010, 84 (16), pp.8021-8032. ⟨10.1128/JVI.02603-09⟩ Article dans une revue hal-02663808v1
Lack of Immunotoxicity After Regional Intravenous (RI) Delivery of rAAV to Nonhuman Primate Skeletal Muscle Alice Toromanoff,Oumeya Adjali,Thibaut T. Larcher,Marcelo Hill,Lydie Guigandet al. Molecular Therapy, 2010, 18 (1), pp.151-160. ⟨10.1038/mt.2009.251⟩ Article dans une revue hal-02666139v1
Évaluation de trois substituts du formol sur la fixation des tissus biologiques d'animaux Lydie Guigand,Mireille Ledevin,B. Fernandez,Julie Massonneau,Yan Cherelet al. Revue Française d'Histotechnologie, 2010, pp.11-24 Article dans une revue hal-02667357v1
Chikungunya disease in nonhuman primates involves long-term viral persistence in macrophages Karine Labadie,Thibaut T. Larcher,Christophe Joubert,Abdelkrim Mannioui,Benoit Delacheet al. Journal of Clinical Investigation, 2010, 120 (3), pp.894-906. ⟨10.1172/JCI40104⟩ Article dans une revue hal-02665274v1
Gene expression profiling in equine polysaccharide storage myopathy revealed inflammation, glycogenesis inhibition, hypoxia and mitochondrial dysfunctions. Eric Barrey,Elodie Mucher,Nicolas Jeansoule,Thibaut Larcher,Lydie Guigandet al. BMC Veterinary Research, 2009, 5 (1), pp.29. ⟨10.1186/1746-6148-5-29⟩ Article dans une revue inserm-00663617v1
Mode of Delivery and Cell Tropism Versus Immunotoxicity of Recombinant AAV in Nonhuman Primate Alice Toromanoff,Oumeya Adjali,Aurélie Moreau,Thibaut T. Larcher,Marcelo Hillet al. Human Gene Therapy, 2009, 20 (6), pp.663 Article dans une revue hal-02656451v1
Study of hypothalamic leptin receptor expression in low-birth-weight piglets and effects of leptin supplementation on neonatal growth and development Linda L. Attig,Jean Djiane,A. Gertler,Olivier Rampin,Thibaut T. Larcheret al. AJP - Endocrinology and Metabolism, 2008, 295 (5), pp.E1117-E1125. ⟨10.1152/ajpendo.90542.2008⟩ Article dans une revue hal-02667579v1
Polysaccharide storage myopathy in Cob Normand draft horses Thibaut T. Larcher,Bérénice Herszberg,S. Molon-Noblot,Lydie Guigand,Stéphane Chaffauxet al. Veterinary Pathology, 2008, 45 (2), pp.154-158. ⟨10.1354/vp.45-2-154⟩ Article dans une revue hal-02658616v1
Persistent left cranial vena cava causing oesophageal obstruction and consequent megaoesophagus in a dog Thibaut T. Larcher,Jérôme Abadie,Françoise A. Roux,Jack-Yves Deschamps,Monique Wyers Journal of Comparative Pathology, 2006, 135 (2-3), pp.150-152. ⟨10.1016/j.jcpa.2006.05.002⟩ Article dans une revue istex hal-02664503v1
Genetic Doping&quot; with erythropoietin cDNA in primate muscle is detectable Françoise Lasne,Laurent Martin,Jacques de Ceaurriz,Thibaut T. Larcher,Philippe Moullieret al. Molecular Therapy, 2004, 10 (3), pp.409-410. ⟨10.1016/j.ymthe.2004.07.024⟩ Article dans une revue hal-02680322v1
Autoimmune anemia in macaques following erythropoietin gene therapy Pierre Chenuaud,Thibaut T. Larcher,Joseph E. Rabinowitz,Nathalie Provost,Yan Cherelet al. Blood, 2004, 103 (9), pp.3303-3304. ⟨10.1182/blood-2003-11-3845⟩ Article dans une revue hal-02680802v1
Optimal design of a single recombinant adeno-associated virus derived from serotypes 1 and 2 to achieve more tightly regulated transgene expression from nonhuman primate muscle Pierre Chenuaud,Thibaut Larcher,Joseph E. Rabinowitz,Nathalie Provost,Béatrice Joussemetet al. Molecular Therapy, 2004, 9 (3), pp.410-418. ⟨10.1016/j.ymthe.2003.12.015⟩ Article dans une revue hal-02678459v1

Ouvrages (2)

Autopsie des bovins Yan Cherel,Patrice Couillandeau,Thibaut Larcher,Olivier Lecomte,Christian Spindler Editions du Point Vétérinaire, 2ème, pp.218, 2017 Ouvrages hal-01806304v1
Autopsie des bovins Yan Cherel,Patrice Couillandeau,Olivier Lecomte,Christian Spindler,Thibaut T. Larcher Editions du Point Vétérinaire, 247 p., 2006, Atlas, 2-86326-229-7 978-2863262290 Ouvrages hal-02824564v1

Chapitre d'ouvrage (1)

Multiphotonic and Harmonic generation microscopy: an attractive label free imaging and non-destructive observation of collagenic and adipose tissues in pathological muscle context Laurence Dubreil,Mireille Ledevin,Claire Lovo,Thibaut Larcher,Romain Fleurissonet al. Microscopy Book Series, 7, 2017, Microscopy and imaging science: practical approaches to applied research and education Chapitre d'ouvrage hal-01524321v1