Valérie Gabelica

Publications

Article dans une revue (58)

New 2,4-bis[(substituted-aminomethyl)phenyl]phenylquinazoline and 2,4-bis[(substituted-aminomethyl)phenyl]phenylquinoline derivatives: synthesis and biological evaluation as novel anticancer agents by targeting G-quadruplex Jean Guillon,Marc Le Borgne,Vittoria Milano,Aurore Guédin-Beaurepaire,Stéphane Moreauet al. Pharmaceuticals, 2024, 17 (1), pp.30. ⟨10.3390/ph17010030⟩ Article dans une revue hal-04390485v1
Mutations in tau protein promote aggregation by favoring extended conformations Kevin Pounot,Clara Piersson,Andrew Goring,Frédéric Rosu,Valérie Gabelicaet al. JACS Au, 2023, 4, pp.92-100. ⟨10.1021/jacsau.3c00550⟩ Article dans une revue hal-04510750v1
A General Framework to Interpret Hydrogen–Deuterium Exchange Native Mass Spectrometry of G-Quadruplex DNA Eric Largy,Matthieu Ranz,Valérie Gabelica Journal of the American Chemical Society, 2023, 145 (49), pp.26843 - 26857. ⟨10.1021/jacs.3c09365⟩ Article dans une revue hal-05238553v1
Native Electrospray Ionization of Multi-Domain Proteins via a Bead Ejection Mechanism Nina Khristenko,Frédéric Rosu,Eric Largy,Jérôme Haustant,Cédric Mesminet al. Journal of the American Chemical Society, 2023, 145 (1), pp.498 - 506. ⟨10.1021/jacs.2c10762⟩ Article dans une revue hal-04119433v1
Thiosugar naphthalene diimide conjugates: G-quadruplex ligands with antiparasitic and anticancer activity Efres Belmonte-Reche,Alessandra Benassi,Pablo Peñalver,Anne Cucchiarini,Aurore Guédinet al. European Journal of Medicinal Chemistry, 2022, 232, pp.114183. ⟨10.1016/j.ejmech.2022.114183⟩ Article dans une revue hal-03807361v1
Phen‐DC 3 Induces Refolding of Human Telomeric DNA into a Chair‐Type Antiparallel G‐Quadruplex through Ligand Intercalation Anirban Ghosh,Marko Trajkovski,Marie‐paule Teulade-Fichou,Valérie Gabelica,Janez Plavec Angewandte Chemie International Edition, 2022, 61 (40), pp.e202207384. ⟨10.1002/anie.202207384⟩ Article dans une revue hal-04119339v1
Optimization of G‐Quadruplex Ligands through a SAR Study by Combining Parallel Synthesis and Screening of Cationic Bis(acylhydrazones) Oksana Reznichenko,Denis Leclercq,Jaime Franco Pinto,Liliane Mouawad,Valérie Gabelicaet al. Chemistry - A European Journal, 2022, ⟨10.1002/chem.202202427⟩ Article dans une revue hal-03837862v1
Negative Electrospray Supercharging Mechanisms of Nucleic Acid Structures Debasmita Ghosh,Frédéric Rosu,Valérie Gabelica Analytical Chemistry, 2022, 94 (44), pp.15386-15394. ⟨10.1021/acs.analchem.2c03187⟩ Article dans une revue hal-04119279v1
Design, Synthesis, and Antiprotozoal Evaluation of New Promising 2,9-Bis[(substituted-aminomethyl)]-4,7-phenyl-1,10phenanthroline Derivatives, a Potential Alternative Scaffold to Drug Efflux Jean Guillon,Anita Cohen,Clotilde Boudot,Sarah Monic,Solène Savrimoutouet al. Pathogens, 2022, 11 (11), pp.1339. ⟨10.3390/pathogens11111339⟩ Article dans une revue inserm-03850360v1
Structural adaptations of electrosprayed aromatic oligoamide foldamers on Ag(111) Dennis Meier,Benedikt Schoof,Jinhua Wang,Xuesong Li,Andreas Walzet al. Chemical Communications, 2022, 58 (64), pp.8938-8941. ⟨10.1039/D2CC03286D⟩ Article dans une revue hal-04275254v1
Adaptive Binding of Alkyl Glycosides by Nonpeptidic Helix Bundles in Water: Toward Artificial Glycolipid Binding Proteins Sung Hyun Yoo,Jérémie Buratto,Arup Roy,Estelle Morvan,Morgane Pascoet al. Journal of the American Chemical Society, 2022, 144 (35), pp.15988-15998. ⟨10.1021/jacs.2c05234⟩ Article dans une revue hal-03862795v1
Quadruplex DNA-guided ligand selection from dynamic combinatorial libraries of acylhydrazones Oksana Reznichenko,Anne Cucchiarini,Valérie Gabelica,Anton Granzhan Organic & Biomolecular Chemistry, 2021, 19 (2), pp.379-386. ⟨10.1039/D0OB01908A⟩ Article dans une revue hal-03186431v1
Native Mass Spectrometry and Nucleic Acid G-Quadruplex Biophysics: Advancing Hand in Hand Valérie Gabelica Accounts of Chemical Research, 2021, 54 (19), pp.3691-3699. ⟨10.1021/ACS.ACCOUNTS.1C00396⟩ Article dans une revue hal-03410850v1
DNA G-quadruplexes for native mass spectrometry in potassium: a database of validated structures in electrospray-compatible conditions Anirban Ghosh,Eric Largy,Valérie Gabelica Nucleic Acids Research, 2021, 49 (4), pp.2333 - 2345. ⟨10.1093/nar/gkab039⟩ Article dans une revue hal-03321816v1
Crystal structures capture multiple stoichiometric states of an aqueous self-assembling oligourea foldamer Gavin Collie,Caterina M. Lombardo,Sung Hyun Yoo,Karolina Pulka-Ziach,Valérie Gabelicaet al. Chemical Communications, 2021, 57 (75), pp.9514-9517. ⟨10.1039/d1cc03604a⟩ Article dans une revue hal-03326761v1
Mass Spectrometry of Nucleic Acid Noncovalent Complexes Eric Largy,Alexander König,Anirban Ghosh,Debasmita Ghosh,Sanae Benabouet al. Chemical Reviews, In press, ⟨10.1021/acs.chemrev.1c00386⟩ Article dans une revue hal-03410847v1
Unprecedented hour-long residence time of a cation in a left-handed G-quadruplex Fernaldo Richtia Winnerdy,Blaž Bakalar,Poulomi Das,Brahim Heddi,Adrien Marchandet al. Chemical Science, 2021, 12 (20), pp.7151-7157. ⟨10.1039/d1sc00515d⟩ Article dans une revue hal-03321839v1
Software requirements for the analysis and interpretation of native ion mobility mass spectrometry data Timothy M. Allison,Perdita Barran,Justin L.P. Benesch,Sarah Cianférani,Mattéo T. Degiacomiet al. Analytical Chemistry, 2020, 92 (16), pp.10881-10890. ⟨10.1021/acs.analchem.9b05792⟩ Article dans une revue hal-02960834v1
Mass-resolved electronic circular dichroism ion spectroscopy Steven Daly,Frederic Rosu,Valérie Gabelica Science, 2020, 368 (6498), pp.1465-1468. ⟨10.1126/science.abb1822⟩ Article dans une revue hal-02882085v1
Collision Cross Sections of Phosphoric Acid Cluster Anions in Helium Measured by Drift Tube Ion Mobility Mass Spectrometry Valentina Calabrese,Hélène Lavanant,Frédéric Rosu,Valérie Gabelica,Carlos Afonso Journal of The American Society for Mass Spectrometry, 2020, 31 (4), pp.969-981. ⟨10.1021/jasms.0c00034⟩ Article dans une revue hal-02541705v1
Compaction of RNA Hairpins and Their Kissing Complexes in Native Electrospray Mass Spectrometry Josephine Abi-Ghanem,Clémence Rabin,Massimiliano Porrini,Frédéric Rosu,Valérie Gabelica Journal of The American Society for Mass Spectrometry, 2020, 31 (10), pp.2035-2043. ⟨10.1021/jasms.0c00060⟩ Article dans une revue hal-03321844v1
Computational strategies and challenges for using native ion mobility mass spectrometry in biophysics and structural biology Timothy M. Allison,Perdita Barran,Sarah Cianférani,Matteo T. Degiacomi,Valérie Gabelicaet al. Analytical Chemistry, 2020, 92 (16), pp.10872-10880. ⟨10.1021/acs.analchem.9b05791⟩ Article dans une revue hal-02960838v1
A two-quartet G-quadruplex topology of human KIT2 is conformationally selected by a perylene derivative Silvia Ceschi,Eric Largy,Valérie Gabelica,Claudia Sissi Biochimie, 2020, 179, pp.77-84. ⟨10.1016/j.biochi.2020.09.015⟩ Article dans une revue hal-03321840v1
Native Hydrogen/Deuterium Exchange Mass Spectrometry of Structured DNA Oligonucleotides Eric Largy,Valérie Gabelica Analytical Chemistry, 2020, 92 (6), pp.4402-4410. ⟨10.1021/acs.analchem.9b05298⟩ Article dans une revue hal-02882153v1
Effective Temperature and Structural Rearrangement in Trapped Ion Mobility Spectrometry Denis Morsa,Emeline Hanozin,Gauthier Eppe,Loïc Quinton,Valérie Gabelicaet al. Analytical Chemistry, 2020, 92 (6), pp.4573-4582. ⟨10.1021/acs.analchem.9b05850⟩ Article dans une revue hal-02882254v1
Native Ion Mobility Mass Spectrometry: When Gas-Phase Ion Structures Depend on the Electrospray Charging Process Nina Khristenko,Jussara Amato,Sandrine Livet,Bruno Pagano,Antonio Randazzoet al. Journal of The American Society for Mass Spectrometry, 2019, 30 (6), pp.1069-1081. ⟨10.1007/s13361-019-02152-3⟩ Article dans une revue hal-02358221v1
DNA and RNA telomeric G-quadruplexes: what topology features can be inferred from ion mobility mass spectrometry? Valentina d'Atri,Valérie Gabelica Analyst, 2019, 144 (20), pp.6074-6088. ⟨10.1039/C9AN01216H⟩ Article dans une revue hal-02358205v1
Recommendations for reporting ion mobility Mass Spectrometry measurements Valérie Gabelica,Alexandre A Shvartsburg,Carlos Afonso,Perdita Barran,Justin L P Beneschet al. Mass Spectrometry Reviews, In press, 38 (3), pp.291-320. ⟨10.1002/mas.21585⟩ Article dans une revue hal-02012317v1
Probing ligand and cation binding sites in G-quadruplex nucleic acids by mass spectrometry and electron photodetachment dissociation sequencing Dababrata Paul,Adrien Marchand,Daniela Verga,Marie-Paule Teulade-Fichou,Sophie Bombardet al. Analyst, In press, 144 (11), pp.3518-3524. ⟨10.1039/C9AN00398C⟩ Article dans une revue hal-02110949v1
Fundamentals of ion mobility spectrometry Valérie Gabelica,Erik Marklund Current Opinion in Chemical Biology, 2018, 42, pp.51-59. ⟨10.1016/j.cbpa.2017.10.022⟩ Article dans une revue hal-01618661v3
Analysis of interaction between telomeric i-motif DNA and a cyclic tetraoxazole compound Shadi Sedghi Masoud,Yudai Yamaoki,Yue Ma,Adrien Marchand,Fernando Richtia Winnerdyet al. ChemBioChem, 2018, 39 (21), pp.2268-2272. ⟨10.1002/cbic.201800425⟩ Article dans une revue hal-01910151v2
Optimizing Native Ion Mobility Q-TOF in Helium and Nitrogen for Very Fragile Noncovalent Structures Valérie Gabelica,Sandrine Livet,Frederic Rosu Journal of The American Society for Mass Spectrometry, 2018, 29 (11), pp.2189-2198. ⟨10.1007/s13361-018-2029-4⟩ Article dans une revue hal-01910186v1
Influence of the Metals and Ligands in Dinuclear Complexes on Phosphopeptide Sequencing by Electron Transfer Dissociation Tandem Mass Spectrometry Daiki Asakawa,Akio Miyazato,Frederic Rosu,Valérie Gabelica Physical Chemistry Chemical Physics, 2018, 20, pp.26597-26607. ⟨10.1039/C8CP04516J⟩ Article dans une revue hal-01910173v1
Electronic Spectroscopy of Isolated DNA Polyanions Steven Daly,Massimiliano Porrini,Frederic Rosu,Valérie Gabelica Faraday Discussions, 2018, Advances in ion spectroscopy - from astrophysics to biology, 217, pp.361-382. ⟨10.1039/C8FD00207J⟩ Article dans une revue hal-02012418v1
Thermal Denaturation of DNA G-Quadruplexes and Their Complexes with Ligands: Thermodynamic Analysis of the Multiple States Revealed by Mass Spectrometry Adrien Marchand,Frederic Rosu,Renato Zenobi,Valérie Gabelica Journal of the American Chemical Society, 2018, 140 (39), pp.12553-12565. ⟨10.1021/jacs.8b07302⟩ Article dans une revue hal-01910198v1
More is not always better: finding the right trade-off between affinity and selectivity of a G-quadruplex ligand Michela Zuffo,Aurore Guédin,Emma-Dune Leriche,Filippo Doria,Valentina Pirotaet al. Nucleic Acids Research, In press, ⟨10.1093/nar/gky607⟩ Article dans une revue hal-01910129v1
Parallel Guanine Duplex and Cytosine Duplex DNA with Uninterrupted Spines of Ag(I)-Mediated Base Pairs Steven M Swasey,Frederic Rosu,Stacy M Copp,Valérie Gabelica,Elisabeth G Gwinn Journal of Physical Chemistry Letters, 2018, 9 (22), pp.6605-6610. ⟨10.1021/acs.jpclett.8b02851⟩ Article dans une revue hal-02012389v1
Design, Synthesis, and Evaluation of 2,9-Bis[(substituted-aminomethyl)phenyl]-1,10-phenanthroline Derivatives as G-Quadruplex Ligands. Nassima Meriem Gueddouda,Rosales Myanou Hurtado,Stéphane Moreau,Luisa Ronga,Rabindra Nath Daset al. ChemMedChem, 2017, 12 (2), pp.146-160. ⟨10.1002/cmdc.201600511⟩ Article dans une revue hal-01461586v1
Drift Tube Ion Mobility: How to Reconstruct Collision Cross Section Distributions from Arrival Time Distributions? Adrien Marchand,Sandrine Livet,Frederic Rosu,Valérie Gabelica Analytical Chemistry, 2017, ⟨10.1021/acs.analchem.7b01736⟩ Article dans une revue hal-01639191v1
Electrostatics Explains the Position-Dependent Effect of G⋅U Wobble Base Pairs on the Affinity of RNA Kissing Complexes Josephine Abi‐ghanem,Clémence Rabin,Massimiliano Porrini,Eric Dausse,Jean‐jacques Toulméet al. ChemPhysChem, 2017, 18 (19), pp.2782-2790. ⟨10.1002/cphc.201700337⟩ Article dans une revue hal-01629266v1
Compaction of Duplex Nucleic Acids upon Native Electrospray Mass Spectrometry Massimiliano Porrini,Frédéric Rosu,Clémence Rabin,Leonardo Darré,Hansel Gómezet al. ACS Central Science, 2017, 3 (5), pp.454-461. ⟨10.1021/acscentsci.7b00084⟩ Article dans une revue hal-04127049v1
Folding and misfolding pathways of G-quadruplex DNA Adrien Marchand,Valérie Gabelica Nucleic Acids Research, 2016, ⟨10.1093/nar/gkw970⟩ Article dans une revue inserm-01385240v1
Selective and Cooperative Ligand Binding to Antiparallel Human Telomeric DNA G-Quadruplexes Adrien Marchand,Dominika Strzelecka,Valérie Gabelica Chemistry - A European Journal, 2016, 22 (28), pp.9551-9555. ⟨10.1002/chem.201601937⟩ Article dans une revue hal-01537094v1
Specific Stabilization of c-MYC and c-KIT G-Quadruplex DNA Structures by Indolylmethyleneindanone Scaffolds K V Diveshkumar,Saaz Sakrikar,Frédéric Rosu,S Harikrishna,Valérie Gabelicaet al. Biochemistry, 2016, 55 (25), pp.3571-3585. ⟨10.1021/acs.biochem.6b00120⟩ Article dans une revue hal-01543404v1
Shaping quaternary assemblies of water-soluble non-peptide helical foldamers by sequence manipulation Gavin Collie,Karolina Pulka-Ziach,Caterina Lombardo,Juliette Fremaux,Frédéric Rosuet al. Nature Chemistry, 2015, 7 (11), pp.871-878. ⟨10.1038/nchem.2353⟩ Article dans une revue hal-05592463v1
Linking molecular models with ion mobility experiments. Illustration with a rigid nucleic acid structure Valentina D 'Atri,Massimiliano Porrini,Frédéric Rosu,Valérie Gabelica Journal of Mass Spectrometry, 2015, 50 (5), pp.711-726. ⟨10.1002/jms.3590⟩ Article dans une revue inserm-01146158v1
Distinctive structural motifs of RNA G-quadruplexes composed of AGG, CGG and UGG trinucleotide repeats Magdalena Malgowska,Dorota Gudanis,Ryszard Kierzek,Eliza Wyszko,Valerie Gabelicaet al. Nucleic Acids Research, 2014, 42 (15), pp.10196. ⟨10.1093/nar/gku710⟩ Article dans une revue inserm-01260985v1
Nucleic acid ion structures in the gas phase Josephine Abi-Ghanem,Valérie Gabelica Physical Chemistry Chemical Physics, 2014, 16 (39), pp.21204 - 21218. ⟨10.1039/C4CP02362E⟩ Article dans une revue inserm-01385789v1
Native Electrospray Mass Spectrometry of DNA G-Quadruplexes in Potassium Solution Adrien Marchand,Valérie Gabelica Journal of The American Society for Mass Spectrometry, 2014, 25 (7), pp.1146. ⟨10.1007/s13361-014-0890-3⟩ Article dans une revue inserm-01385783v1
Assembly of Palladium(II) and Platinum(II) Metallo-Rectangles with a Guanosine-Substituted Terpyridine and Study of Their Interactions with Quadruplex DNA Sushobhan Ghosh,Oscar Mendoza,Leticia Cubo,Frederic Rosu,Valérie Gabelicaet al. Chemistry - A European Journal, 2014, 20 (16), pp.4772 - 4779. ⟨10.1002/chem.201304905⟩ Article dans une revue inserm-01387138v1
Assembly of chemically modified G-rich sequences into tetramolecular DNA G-quadruplexes and higher order structures Jun Zhou,Dursun Nizam Korkut,Frédéric Rosu,Samir Amrane,Valérie Gabelicaet al. Methods, 2014, Nucleic Acids Nanotechnology, 67, pp.159 - 168. ⟨10.1016/j.ymeth.2014.01.004⟩ Article dans une revue inserm-01385785v1
A pilgrim's guide to G-quadruplex nucleic acid folding Valérie Gabelica Biochimie, 2014, 105, pp.1 - 3. ⟨10.1016/j.biochi.2014.08.007⟩ Article dans une revue inserm-01385787v1
Ammonium ion binding to DNA G-quadruplexes: do electrospray mass spectra faithfully reflect the solution-phase species? Françoise Balthasart,Janez Plavec,Valérie Gabelica Journal of The American Society for Mass Spectrometry, 2013, 24 (1), pp.1-8. ⟨10.1007/s13361-012-0499-3⟩ Article dans une revue inserm-00980848v1
Multiple and cooperative binding of fluorescence light-up probe Thioflavin T with human telomere DNA G-quadruplex Valérie Gabelica,Ryuichi Maeda,Takeshi Fujimoto,Hidenobu Yaku,Takashi Murashimaet al. Biochemistry, 2013, 52, pp.5620 - 5628. ⟨10.1021/bi4006072⟩ Article dans une revue inserm-01388017v1
Zwitterionic i-motif structures are preserved in DNA negatively charged ions produced by electrospray mass spectrometry Frédéric Rosu,Valérie Gabelica,Laure Joly,Gilles Grégoire,E. de Pauw Physical Chemistry Chemical Physics, 2010, 12 (41), pp.13448-13454 Article dans une revue hal-00533459v1
Infrared Signature of DNA G-quadruplexes in the Gas Phase Valérie Gabelica,Frédéric Rosu,E. de Pauw,Joël Lemaire,Jean-Christophe Gilletet al. Journal of the American Chemical Society, 2008, 130, pp.1810 Article dans une revue hal-00434106v1
Ligands playing musical chairs with G-quadruplex DNA: a rapid and simple displacement assay for identifying selective G-quadruplex binders David Monchaud,Clémence Allain,Hélène Bertrand,Nicolas Smargiasso,Frédéric Rosuet al. Biochimie, 2008, 90 (8), pp.1207-1223. ⟨10.1016/j.biochi.2008.02.019⟩ Article dans une revue hal-00311781v1
Stabilization and structure of telomeric and c-myc region intramolecular G-quadruplexes: the role of central cations and small planar ligands. Valérie Gabelica,Erin S. Baker,Marie-Paule Teulade-Fichou,Edwin de Pauw,Michael T. Bowers Journal of the American Chemical Society, 2007, 129 (4), pp.895-904. ⟨10.1021/ja065989p⟩ Article dans une revue istex hal-00258139v1

Communication dans un congrès (6)

Design, synthesis, biophysical and antiprotozoal evaluation of new promising 2,9-bis[(substituted-aminomethyl)]-4,7-phenyl-1,10-phenanthroline derivatives by targeting G-quadruplex Jean Guillon,A. Cohen,Cédric Boudot,S. Monic,Solène Savrimoutouet al. 8th International Electronic Conference on Medicinal Chemistry, Sciforum sponsored by Pharmaceuticals, Nov 2022, BORDEAUX CEDEX, France Communication dans un congrès hal-04666387v1
Collision cross sections of phosphoric acid cluster anions and their use as calibrants for traveling wave ion mobility Hélène Lavanant,Valentina Calabrese,Frédéric Rosu,Valérie Gabelica,Carlos Afonso 67th ASMS Conference on Mass Spectrometry and Allied Topics, Jun 2019, Atlanta, United States Communication dans un congrès hal-03018411v1
Ion Mobility Spectrometry: Towards Standard Operating Procedures (Ion Mobility MS Interest Group workshop report) Valérie Gabelica,Brian H Clowers,Stephen J Valentine 65th ASMS Conference on Mass Spectrometry and Allied Topics, ASMS, Jun 2017, Indianapolis, United States Communication dans un congrès hal-01557049v1
Ion mobility:How to reconstruct collision cross section distributions from arrival time distributions measured in drift tube IMS Adrien Marchand,Sandrine Livet,Frédéric Rosu,Valérie Gabelica ASMS 2017 65th ASMS Conference on Mass Spectrometry and Allied Topics, Jun 2017, Indianapolis, United States Communication dans un congrès hal-01547797v1
Multi-scale Simulations Coupled with Ion Mobility Experiments Reveal the Fate of Nucleic Acids in the Gas Phase Massimiliano Porrini,Clémence Rabin,Josephine Abi-Ghanem,Frédéric Rosu,Leonardo Darréet al. 64th ASMS Conference on Mass Spectrometry and Allied Topics, Jun 2016, San Antonio, United States Communication dans un congrès hal-01562153v1
Cation binding to nucleic acids Adrien Marchand,Clémence Rabin,Sandrine Livet,Solenne Delahaye,Valentina d'Atriet al. ASMS 2016 64th ASMS Conference on Mass Spectrometry and Allied Topics, Jun 2016, San Antonio, United States Communication dans un congrès hal-01562180v1

Poster de conférence (1)

What happens to DNA duplexes in the gas phase? Massimiliano Porrini,Frédéric Rosu,Valérie Gabelica 63rd ASMS Conference on Mass Spectrometry and Allied Topics (ASMS 2015), May 2015, St Louis, United States. , Proceedings of the ASMS Annual Conference 2015 St. Louis, 2015 Poster de conférence hal-01562195v1

Chapitre d'ouvrage (1)

Ion Mobility -Mass Spectrometry: An Overview Valérie Gabelica Frank Sobott; Alison Ashcroft. Ion Mobility-Mass Spectrometry: Fundamentals and Applications, Royal Society of Chemistry, pp.1-25, 2021, New Developments in Mass Spectrometry, 978-1-83916-166-7. ⟨10.1039/9781839162886-00001⟩ Chapitre d'ouvrage hal-03463389v1

Pré-publication, Document de travail (2)

Mutations in tau protein promote aggregation by favoring extended conformations Kevin Pounot,Clara Piersson,Andrew Goring,Frédéric Rosu,Valérie Gabelicaet al. 2023 Pré-publication, Document de travail (preprint/prepublication) hal-04255772v1
Introduction à la spectrométrie de masse à mobilité ionique Valérie Gabelica 2021 Pré-publication, Document de travail hal-03463401v1