Vincent Aranzana-Climent

Publications

Article dans une revue (23)

A freely accessible, adaptable hollow-fiber setup to reproduce first-order absorption: illustration with linezolid cerebrospinal fluid pharmacokinetic data Noémie Prébonnaud,Alexia Chauzy,Nicolas Grégoire,Claire Dahyot-Fizelier,Christophe Adieret al. Microbiology Spectrum, 2025, ⟨10.1128/spectrum.00051-25⟩ Article dans une revue hal-05085650v1
An integrative and translational PK/PD modelling approach to explore the combined effect of polymyxin B and minocycline against &lt;i&gt;Klebsiella pneumoniae&lt;/i&gt; Chenyan Zhao,Sanne van den Berg,Zhigang Wang,Anna Olsson,Vincent Aranzana-Climentet al. International Journal of Antimicrobial Agents, 2025, 65 (3), pp.107443. ⟨10.1016/j.ijantimicag.2025.107443⟩ Article dans une revue hal-05144878v1
Prediction of higher ceftazidime–avibactam concentrations in the human renal interstitium compared with unbound plasma using a minimal physiologically based pharmacokinetic model developed in rats and pigs through microdialysis Maxime Vallée,Vincent Aranzana-Climent,Jérémy Moreau,Isabelle Lamarche,Théo Fontanieret al. Antimicrobial Agents and Chemotherapy, 2025, 69 (3), pp.e0151824. ⟨10.1128/aac.01518-24⟩ Article dans une revue hal-04950970v1
Optimizing antimicrobial susceptibility testing: cost and environmental benefits of MIC volume reduction Jonathan Clarhaut,Jeremy Moreau,Tom Collet,Emma Babiard,Vincent Aranzana-Climentet al. Antimicrobial Agents and Chemotherapy, 2025, 69 (12), pp.e0070425. ⟨10.1128/aac.00704-25⟩ Article dans une revue hal-05321893v1
Model-informed drug development for antimicrobials: translational pharmacokinetic-pharmacodynamic modelling of apramycin to facilitate prediction of efficacious dose in complicated urinary tract infections Irene Hernández-Lozano,Vincent Aranzana-Climent,Sha Cao,Carina Matias,Jon Ulf Hansenet al. Journal of Antimicrobial Chemotherapy, 2024, Online ahead of print. ⟨10.1093/jac/dkae409⟩ Article dans une revue hal-04800350v1
Distribution tissulaire du Meropeneme-Vaborbactam dans le rein et la prostate chez le rat et le cochon sain par micro-dialyse Théo Fontanier,Isabelle Lamarche,Céline Barc,Vincent Aranzana-Climent,Hélène Mirfendereskiet al. Progrès en Urologie - FMC, 2024, 34 (7), pp.S134-S135. ⟨10.1016/j.fpurol.2024.07.188⟩ Article dans une revue hal-04906538v1
Étude de la distribution tissulaire du ceftazidime-avibactam dans le parenchyme rénal de rats et de porcs par technique de micro-dialyse Maxime Vallée,Jérémy Moreau,Théo Fontanier,Isabelle Lamarche,Hélène Mirfendereskiet al. Progrès en Urologie - FMC, 2024, 34 (7), pp.S127-S128. ⟨10.1016/j.fpurol.2024.07.179⟩ Article dans une revue hal-04906357v1
Tissue distribution of Ceftazidime-Avibactam in kidney tissue in healthy rats and pigs using a microdialysis technique Maxime Vallée,Jérémy Moreau,Isabelle Lamarche,Céline Barc,Nathalie Kasal-Hocet al. European Urology, 2024, Abstracts EAU24 - 39th Annual EAU Congress, 85 (Supplément 1), pp.S127-S128 Article dans une revue hal-04913348v1
Integration of individual preclinical and clinical anti‐infective PKPD data to predict clinical study outcomes Vincent Aranzana-Climent,Wisse van Os,Amir Nutman,Jonathan Lellouche,Yael Dishon-Benattaret al. Clinical and Translational Science., 2024, 17 (7), pp.e13870. ⟨10.1111/cts.13870⟩ Article dans une revue hal-04645902v1
Pharmacokinetic and pharmacodynamic properties of polymyxin B in Escherichia coli and Klebsiella pneumoniae murine infection models Aart van der Meijden,Vincent Aranzana-Climent,Heleen van der Spek,Brenda de Winter,William Couetet al. Journal of Antimicrobial Chemotherapy, 2023, 78 (3), pp.832-839. ⟨10.1093/jac/dkad022⟩ Article dans une revue hal-04088061v1
Characterization of Pseudomonas aeruginosa resistance to ceftolozane-tazobactam due to ampC and/or ampD mutations observed during treatment using semi-mechanistic PKPD modeling Luc Deroche,Vincent Aranzana-Climent,Albane Rozenholc,Laure Prouvensier,Léa Darnaudet al. Antimicrobial Agents and Chemotherapy, 2023, ⟨10.1128/aac.00480-23⟩ Article dans une revue hal-04227340v1
Variability of murine bacterial pneumonia models used to evaluate antimicrobial agents Rakel Arrazuria,Bernhard Kerscher,Karen Huber,Jennifer Hoover,Carina Vingsbo Lundberget al. Frontiers in Microbiology, 2022, 13, ⟨10.3389/fmicb.2022.988728⟩ Article dans une revue hal-04388991v1
Pharmacokinetic/pharmacodynamic models for time courses of antibiotic effects Iris Minichmayr,Vincent Aranzana-Climent,Lena Friberg International Journal of Antimicrobial Agents, 2022, 60 (3), pp.106616. ⟨10.1016/j.ijantimicag.2022.106616⟩ Article dans une revue hal-04389002v1
Translational in vitro and in vivo PKPD modelling for apramycin against Gram-negative lung pathogens to facilitate prediction of human efficacious dose in pneumonia Vincent Aranzana-Climent,Diarmaid Hughes,Sha Cao,Magdalena Tomczak,Malgorzata Urbaset al. Clinical Microbiology and Infection, 2022, 28 (10), pp.1367-1374. ⟨10.1016/j.cmi.2022.05.003⟩ Article dans une revue hal-04389011v1
A New Pharmacokinetic-Pharmacodynamic Model To Characterize the Inoculum Effect of Acinetobacter baumannii on Polymyxin B In Vitro Grace Akrong,Alexia Chauzy,Vincent Aranzana-Climent,Mathilde Lacroix,Luc Derocheet al. Antimicrobial Agents and Chemotherapy, 2022, 66 (1), pp.e0178921. ⟨10.1128/AAC.01789-21⟩ Article dans une revue hal-03615758v1
PKPD Modeling of the Inoculum Effect of Acinetobacter baumannii on Polymyxin B in vivo Alexia Chauzy,Grace Akrong,Vincent Aranzana-Climent,Jérémy Moreau,Laure Prouvensieret al. Frontiers in Pharmacology, 2022, 13, pp.842921. ⟨10.3389/fphar.2022.842921⟩ Article dans une revue hal-03615739v1
Expert workshop summary: Advancing toward a standardized murine model to evaluate treatments for antimicrobial resistance lung infections Rakel Arrazuria,Bernhard Kerscher,Karen Huber,Jennifer Hoover,Carina Vingsbo Lundberget al. Frontiers in Microbiology, 2022, 13, ⟨10.3389/fmicb.2022.988725⟩ Article dans une revue hal-04388986v1
A Minimal Physiologically Based Pharmacokinetic Model to Characterize CNS Distribution of Metronidazole in Neuro Care ICU Patients Alexia Chauzy,Salim Bouchène,Vincent Aranzana-Climent,Jonathan Clarhaut,Christophe Adieret al. Antibiotics, 2022, 11 (10), pp.1293. ⟨10.3390/antibiotics11101293⟩ Article dans une revue hal-03906712v1
Efficacy of EBL-1003 (apramycin) against Acinetobacter baumannii lung infections in mice Katja Becker,Vincent Aranzana-Climent,Sha Cao,Anna Nilsson,Reza Shariatgorjiet al. Clinical Microbiology and Infection, 2021, 27 (9), pp.1315-1321. ⟨10.1016/j.cmi.2020.12.004⟩ Article dans une revue hal-04389019v1
Semi-mechanistic PK-PD modelling of combined polymyxin B and minocycline against a polymyxin-resistant strain of Acinetobacter baumannii Vincent Aranzana-Climent,Julien Buyck,Younes Smani,Jerónimo Pachón-Diaz,Sandrine Marchandet al. Clinical Microbiology and Infection, 2020, ⟨10.1016/j.cmi.2020.01.017⟩ Article dans une revue hal-02482129v1
Preclinical Pharmacokinetic and Pharmacodynamic Data To Support Cefoxitin Nebulization for the Treatment of Mycobacterium abscessus Shachi Mehta,Vincent Aranzana-Climent,Blandine Rammaert,Nicolas Grégoire,Sandrine Marchandet al. Antimicrobial Agents and Chemotherapy, 2019, 63 (7), ⟨10.1128/AAC.02651-18⟩ Article dans une revue hal-02477844v1
Clinical Pharmacokinetics and Pharmacodynamics of Colistin Nicolas Grégoire,Vincent Aranzana-Climent,Sophie Magréault,Sandrine Marchand,William Couet Clinical Pharmacokinetics, 2017, Epub ahead of print. ⟨10.1007/s40262-017-0561-1⟩ Article dans une revue inserm-01528483v1
A Generic Multi-Compartmental CNS Distribution Model Structure for 9 Drugs Allows Prediction of Human Brain Target Site Concentrations Yumi Yamamoto,Pyry Välitalo,Dirk-Jan van den Berg,Robin Hartman,Willem van den Brinket al. Pharmaceutical Research, 2017, 34 (2), pp.333-351. ⟨10.1007/s11095-016-2065-3⟩ Article dans une revue hal-02472510v1

Communication dans un congrès (2)

Distribution tissulaire du Meropeneme-Vaborbactam dans le rein et la prostate chez le rat et le cochon sain par micro-dialyse Théo Fontanier,Isabelle Lamarche,Céline Barc,Vincent Aranzana-Climent,Hélène Mirfendereskiet al. 118e Congrès français d’urologie, Association française d'urologie (AFU), Nov 2024, Paris, France. pp.S134-S135 Communication dans un congrès hal-04906501v1
Étude de la distribution tissulaire du ceftazidime-avibactam dans le parenchyme rénal de rats et de porcs par technique de micro-dialyse Maxime Vallée,Jérémy Moreau,Théo Fontanier,Isabelle Lamarche,Hélène Mirfendereskiet al. 118e Congrès français d’urologie, Association française d'urologie (AFU), Nov 2024, Paris, France. pp.S127-S128, ⟨10.1016/j.fpurol.2024.07.179⟩ Communication dans un congrès hal-04906258v1

Poster de conférence (7)

Meropenem-Vaborbactam distribution in renal and prostatic interstitium tissues in rats and pigs using microdialysis Théo Fontanier,Vincent Aranzana-Climent,Isabelle Lamarche,J. Moreau,Céline Barcet al. 40th Annual EAU Congress, Mar 2025, Madrid, Spain. , European Urology, numéro spécial : Abstracts EAU25 - 40th Annual EAU Congress, 87 (Supplément 2), pp.S149, 2025, European Urology, numéro spécial : Abstracts EAU25 - 40th Annual EAU Congress. ⟨10.1016/j.eururo.2025.09.2603⟩ Poster de conférence hal-05489327v1
Simulation-based prediction of pharmacokinetic/pharmacodynamic (PK/PD) index for linezolid to treat cerebral infections in critically ill patients Michael Burtin,Noémie Prébonnaud,Sandrine Marchand,Nicolas Grégoire,Claire Dahyot-Fizelieret al. 33rd PAGE meeting, Jun 2025, Thessalokini, Greece. Poster de conférence hal-05240779v1
Tissue distribution of Ceftazidime-Avibactam in kidney tissue in healthy rats and pigs using a microdialysis technique Maxime Vallée,Jérémy Moreau,Isabelle Lamarche,Céline Barc,Nathalie Kasal-Hocet al. 39e Congrès de l'Association européenne d'urologie (EAU24), Apr 2024, Paris, France. , European Urology, 85 (Supplément 1), pp.S127-S128, Abstracts EAU24 - 39th Annual EAU Congress. ⟨10.1016/S0302-2838(24)00177-5⟩ Poster de conférence hal-04906706v1
Synergistic interaction between antifungal agents against Candida guilliermondii using pharmacodynamics-modelling approach Adrien Baillod,Vincent Aranzana-Climent,Kevin Point,Sandrine Marchand,Kévin Brunet 34th European Congress of Clinical Microbiology and Infectious Diseases (ECCMID), Apr 2024, Barcelona, Spain Poster de conférence hal-04571002v1
Tissue distribution of Ceftazidime-Avibactam in kidney tissue in healthy rats and pigs using a microdialysis technique Maxime Vallée,Céline Barc,Jérémy Moreau,Nathalie Kasal-Hoc,Isabelle Lamarcheet al. 34th European Congress of Clinical Microbiology and Infectious Diseases (ECCMID), Apr 2024, Barcelona, Spain Poster de conférence hal-04571042v1
Spotting method as a high throughput alternative to the conventional spread plating method Vincent Aranzana-Climent,Laure Prouvensier,Tom Collet,Sandrine Marchand,Nicolas Grégoireet al. 34th European Congress of Clinical Microbiology and Infectious Diseases (ECCMID), Apr 2024, Barcelona, Spain Poster de conférence hal-04575530v1
Development and validation of a PBPK model of gepotidacin in rats to predict exposure in human prostate Vincent Aranzana-Climent,Valentin Al Jalali,Hwa-Ping Feng,Karen O'Dwyer,William Couetet al. 34th European Congress of Clinical Microbiology and Infectious Diseases (ECCMID), Apr 2024, Barcelona, Spain Poster de conférence hal-04571063v1

Pré-publication, Document de travail (1)

A freely accessible, adaptable hollow-fiber setup to reproduce first-order absorption: illustration with linezolid cerebrospinal fluid pharmacokinetic data Noémie Prébonnaud,Alexia Chauzy,Nicolas Grégoire,Claire Dahyot-Fizelier,Christophe Adieret al. 2025 Pré-publication, Document de travail hal-05030769v1

Thèse (2)

Apport de la modélisation semi-mécanistique dans l'étude pharmacocinétique/pharmacodynamique des antibiotiques seuls et en combinaison dans la lutte contre les bactéries résistantes Vincent Aranzana-Climent Maladies infectieuses. Université de Poitiers, 2019. Français. ⟨NNT : 2019POIT1802⟩ Thèse tel-02535136v1
Apport de la modélisation semi-mécanistique dans l'étude pharmacocinétique/pharmacodynamique des antibiotiques seuls et en combinaison dans la lutte contre les bactéries résistantes. Vincent Aranzana-Climent Sciences du Vivant [q-bio]. Université de Poitiers (France), 2019. Français. ⟨NNT : ⟩ Thèse tel-02533266v1