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Vincent AUCAGNE

11
Documents
Identifiants chercheurs

Présentation

EDUCATION --------- - 1999-2002 - PhD in organic chemistry with higher honors, Université d'Orléans defended in 2003, grant from the French Ministry of Research and Technology - 1998-1999 -Master in chemistry and physicochemistry of bioactive compounds with higher honors, Universités Paris V, Paris XI and Orléans PROFESSIONAL EXPERIENCES ------------------------ - 2006 - CNRS Research manager, Centre de Biophysique Moléculaire, Orléans - Team of Dr A. Delmas, Development of new tools for the solid-phase total synthesis of native or modified proteins and glycoproteins - 2004-2006 - Postdoctoral Research Associate, School of Chemistry, University of Edinburgh UK - Team of Prof. D. A. Leigh, Towards the total synthesis of the lasso peptide Microcin J25; Active template methodologies for the synthesis of mechanically-interlocked architectures - 2002-2003 - Fixed-term Lecturer in organic chemistry (ATER, one year fellowship) Université d'Orléans - Institut de Chimie Organique et Analytique (I.C.O.A.), Team of Prof. L. A. Agrofoglio, synthesis of new nucleoside analogues with antiviral activities - 1999-2002 - PhD in organic chemistry , I.C.O.A., team of Prof. P. Rollin Sulfur-containing phosphonium salts and anomeric Wittig reaction. Evaluation of vinylthio-functionalized alditols – new tools for stereocontrolled ring closure reactions - 1998-1998 - Postgraduate research fellow , I.C.O.A.; team of Prof. P. Rollin Synthesis of C-glycosidic analogues of glucosinolates RESEARCH INTERESTS ------------------ - Synthetic chemistry of biomacromolecules : Total synthesis of small proteins and glycoproteins. Click chemistry. Native chemical ligation Amino-acids, carbohydrates and nucleoside analogues. Modified or bioconjugated proteins. Synthetic vaccines. Drug-delivery. - Solid-phase organic synthesis : Solid-phase peptide and bio-macromolecule ligation. Solid-phase purification - Supramolecular Chemistry : Rotaxanes, Catenanes, Mechanically-interlocked architectures. Coordination chemistry - Thiochemistry : Thioester and thioacid peptides. Sulfonylated strained aminoacids. Sulfur as a tool in organic and bioorganic chemistry. - Referee for Letters in Organic Chemistry, the Journal of Organic Chemistry, the Journal of the American Chemical Society. Member of the French and American Chemical Societies

Publications

"karine-loth"
"herve-meudal"

Enabling the synthesis of hydrophobic proteins using NCL-labile solubilizing tags: a case study of Crassostrea gigas big defensin 3

A. Asokan , Noémie de San Nicolas , H. Meudal , K. Loth , Delphine Destoumieux-Garzon
22nd GFPP / BPGM5 French-Belgian Joint Meeting, Groupe Français des Peptides et Protéines, May 2022, Port Leucate, France
Communication dans un congrès hal-03976595v1

Gga-AvBD11, the archetype of a new structural family of defensins

H. Meudal , Nicolas Guyot , K. Loth , G. Jousset , S. Trapp
21e réunion du Groupe Français des Peptides et des Protéines (GFPP21), May 2019, Amboise, France
Communication dans un congrès hal-02892790v1

1ère structure 3D d’une défensine à double motif β-défensine, Gga-AvBD11 du poulet Gallus gallus, et explorations fonctionnelles

Nicolas Guyot , Hervé Meudal , Karine Loth , Guillaume Jousset , Anne Silvestre
5es Journées GDR MuFoPAM, Centre National de la Recherche Scientifique (CNRS). FRA., Oct 2018, Paris, France
Communication dans un congrès hal-02788993v1

Chemical synthesis and natural abundance NMR: an efficient tandem to unravel 3D structures of unlabeled disulfide rich peptides

Herve Meudal , Françoise Paquet , Laurence Jouvensal , V. Aucagne , A.F. Delmas
21e congrès du Groupe Français des Peptides et des Protéines (GFPP21), May 2019, Amboise, France
Poster de conférence hal-02919180v1

A new structural family for antimicrobial defensins

H. Meudal , K. Loth , G. Jousset , V. Aucagne , Nicolas Guyot
NMR : a tool for biology XIth, Jan 2019, Paris, France
Poster de conférence hal-02919171v1

Chemical synthesis and natural abundance NMR: An efficient tandem to unravel 3D structures of Disulfide Rich Miniproteins

H. Meudal , Laurence Jouvensal , K. Loth , Françoise Paquet , V. Aucagne
35th European Peptide Symposium, Aug 2018, Dublin, Ireland
Poster de conférence hal-02920483v1

Synthèse chimique et RMN en abondance naturelle : un tandem efficace pour résoudre les structures 3D de peptides/protéines riches en ponts disulfure

Françoise Paquet , H. Meudal , Laurence Jouvensal , K. Loth , V. Aucagne
5es journées annuelles du GDR MuFoPAM, Oct 2018, Paris, France
Poster de conférence hal-02920025v1

NCL-based synthesis, 3D structure and first insight into antimicrobial properties of Cg-BigDef1, an oyster big defensin active at high salinity

A. Delmas , K. Loth , Herve Meudal , V. Terrier , R.D. Rosa
NMR: a tool for Biology Xth, Jan 2017, Paris, France
Poster de conférence hal-02453460v1

NCL-based synthesis, 3D structure and first insight into antimicrobial properties of Cg-BigDef1, an oyster big defensin active at high salinity

A.F. Delmas , K. Loth , Herve Meudal , V.P. Terrier , R.D. Rosa
20e congrès annuel du Groupe Français des Peptides et Protéines (GFPP), Mar 2017, Arcachon, France
Poster de conférence hal-02894301v1