Vincent AUCAGNE

Identifiants chercheurs

IdHAL :

vincent-aucagne

ORCID :

0000-0002-2647-0188

IdRef :

077138120

Présentation

EDUCATION

1999-2002 - PhD in organic chemistry with higher honors, Université d'Orléans defended in 2003, grant from the French Ministry of Research and Technology

1998-1999 -Master in chemistry and physicochemistry of bioactive compounds with higher honors, Universités Paris V, Paris XI and Orléans

PROFESSIONAL EXPERIENCES

2006 - CNRS Research manager, Centre de Biophysique Moléculaire, Orléans - Team of Dr A. Delmas, Development of new tools for the solid-phase total synthesis of native or modified proteins and glycoproteins

2004-2006 - Postdoctoral Research Associate, School of Chemistry, University of Edinburgh UK - Team of Prof. D. A. Leigh, Towards the total synthesis of the lasso peptide Microcin J25; Active template methodologies for the synthesis of mechanically-interlocked architectures

2002-2003 - Fixed-term Lecturer in organic chemistry (ATER, one year fellowship) Université d'Orléans - Institut de Chimie Organique et Analytique (I.C.O.A.), Team of Prof. L. A. Agrofoglio, synthesis of new nucleoside analogues with antiviral activities

1999-2002 - PhD in organic chemistry , I.C.O.A., team of Prof. P. Rollin Sulfur-containing phosphonium salts and anomeric Wittig reaction. Evaluation of vinylthio-functionalized alditols – new tools for stereocontrolled ring closure reactions

1998-1998 - Postgraduate research fellow , I.C.O.A.; team of Prof. P. Rollin Synthesis of C-glycosidic analogues of glucosinolates

RESEARCH INTERESTS

Synthetic chemistry of biomacromolecules : Total synthesis of small proteins and glycoproteins. Click chemistry. Native chemical ligation Amino-acids, carbohydrates and nucleoside analogues. Modified or bioconjugated proteins. Synthetic vaccines. Drug-delivery.

Solid-phase organic synthesis : Solid-phase peptide and bio-macromolecule ligation. Solid-phase purification

Supramolecular Chemistry : Rotaxanes, Catenanes, Mechanically-interlocked architectures. Coordination chemistry

Thiochemistry : Thioester and thioacid peptides. Sulfonylated strained aminoacids. Sulfur as a tool in organic and bioorganic chemistry.

Referee for Letters in Organic Chemistry, the Journal of Organic Chemistry, the Journal of the American Chemical Society. Member of the French and American Chemical Societies

Publications

Article dans une revue (74)

Progestogen priming is not essential to trigger ovulation in seasonal anoestrus ewes injected twice with a synthetic kisspeptin analogue Didier Lomet,Vincent Robert,Caroline Decourt,F. Derouin-Tochon,E. Hommetet al. Animal, 2026, 20 (3), pp.101779. ⟨10.1016/j.animal.2026.101779⟩ Article dans une revue hal-05575687v1
Identification, occurrence and prevention of aspartimide-related byproducts in chemical protein synthesis El Hadji Cisse,Vincent Aucagne Chemical Science, 2025, 16 (32), pp.14496 - 14508. ⟨10.1039/d5sc03824c⟩ Article dans une revue hal-05230442v1
Versatile fluorescent homobifunctional crosslinkers: expedient synthesis and application to di-affibody constructs for specific HER2+ cancer cell recognition Eric Kaya,Fabienne Fasani,Carlo Pifferi,Catherine Grillon,Vincent Aucagneet al. Bioorganic and Medicinal Chemistry, 2025, pp.118494. ⟨10.1016/j.bmc.2025.118494⟩ Article dans une revue hal-05376098v1
The antimicrobial activity of ETD151 defensin is dictated by the presence of glycosphingolipids in the targeted organisms Ons Kharrat,Yoshiki Yamaryo-Botté,Rouba Nasreddine,Sébastien Voisin,Thomas Aumeret al. Proceedings of the National Academy of Sciences of the United States of America, 2025, 122 (7), pp.e2415524122. ⟨10.1073/pnas.2415524122⟩ Article dans une revue hal-05304638v1
The kisspeptin analog C6 reverses reproductive dysfunction in a mouse model of hyperprolactinemia Chloe Beaudou,Louise Sionneau,Didier Lomet,Vincent Robert,Peggy Jarrier-Gaillardet al. Reproduction [Cambridge], 2025, 169 (4), pp.e250036. ⟨10.1530/REP-25-0036⟩ Article dans une revue hal-05135772v1
Molecular recognition of fungal methylated glucosylceramides by ETD151 defensin Ons Kharrat,Françoise Paquet,Rouba Nasreddine,Jean-Baptiste Madinier,Reine Nehméet al. Journal of Biological Chemistry, 2025, 301 (9), pp.110587. ⟨10.1016/j.jbc.2025.110587⟩ Article dans une revue hal-05250295v1
Strong impact of orally administered BCR4 defensin on aphid survival, embryo development, and symbiotic cells in three Acyrthosiphon pisum parthenogenetic lines Hugo Terrasson,Karen Gaget,Garance Lapetoule,Isabelle Rahioui,François Renozet al. Journal of Pest Science, 2025, 98 (3), pp.1599-1612. ⟨10.1007/s10340-025-01923-0⟩ Article dans une revue hal-05127596v1
Teichoic Acids Play a Key Role in the Antibacterial Activity of Big Defensins against Staphylococcus aureus Noémie de San Nicolas,Albane Jouault,Aromal Asokan,Lhousseine Touqui,Imane El Fannassiet al. ACS Infectious Diseases, 2025, 11 (12), pp.3542-3552. ⟨10.1021/acsinfecdis.5c00646⟩ Article dans une revue hal-05375669v1
Ubiquitylation of nucleic acids by DELTEX ubiquitin E3 ligase DTX3L Kang Zhu,Chatrin Chatrin,Marcin J Suskiewicz,Vincent Aucagne,Benjamin Fosteret al. EMBO Reports, 2024, 25 (10), pp.4172-4189. ⟨10.1038/s44319-024-00235-1⟩ Article dans une revue hal-04739061v1
An efficient site-selective, dual bioconjugation approach exploiting N-terminal cysteines as minimalistic handles to engineer tailored anti-HER2 affibody conjugates Ana Novak,Florian Kersaudy,Sylvie Berger,Séverine Morisset-Lopez,François Lefoulonet al. European Journal of Medicinal Chemistry, 2023, 260, pp.115747. ⟨10.1016/j.ejmech.2023.115747⟩ Article dans une revue hal-04222710v1
DELTEX E3 ligases ubiquitylate ADP-ribosyl modification on protein substrates Kang Zhu,Marcin Suskiewicz,Andrea Hloušek-Kasun,Hervé Meudal,Andreja Mikočet al. Science Advances , 2022, 8 (40), ⟨10.1126/sciadv.add4253⟩ Article dans une revue hal-03862525v1
Treating mares with the long-acting kisspeptin analog C6 increases circulating gonadotropins but does not trigger ovulation Flavie Derouin Tochon,Didier Lomet,Vincent Robert,Fabrice Reigner,Philippe Barrièreet al. Agriculture, 2022, 12 (11), pp.1846. ⟨10.3390/agriculture12111846⟩ Article dans une revue hal-03862471v1
Functional Diversification of Oyster Big Defensins Generates Antimicrobial Specificity and Synergy against Members of the Microbiota Noémie de San Nicolas,Aromal Asokan,Rafael D Rosa,Sébastien N Voisin,Marie-Agnès Traverset al. Marine drugs, 2022, 20 (12), pp.745. ⟨10.3390/md20120745⟩ Article dans une revue hal-04246173v1
Aphid BCR4 Structure and Activity Uncover a New Defensin Peptide Superfamily Karine Loth,Nicolas Parisot,Françoise Paquet,Hugo Terrasson,Catherine Sivignonet al. International Journal of Molecular Sciences, 2022, 23 (20), pp.12480. ⟨10.3390/ijms232012480⟩ Article dans une revue hal-03862651v1
Real-Time Fluorescence Microscopy on Living E. coli Sheds New Light on the Antibacterial Effects of the King Penguin beta-Defensin AvBD103b Céline Landon,Yanyu Zhu,Mainak Mustafi,Jean-Baptiste Madinier,Dominique Lelièvreet al. International Journal of Molecular Sciences, 2022, This article belongs to the Special Issue Antimicrobial Peptides: Structure and Mechanism of Biological Activity, 23 (2057), pp.2057. ⟨10.3390/ijms23042057⟩ Article dans une revue hal-03860107v1
The Kisspeptin analogue C6 induces ovulation in jennies Diana Fanelli,Massimiliano Beltramo,Giuseppe Conte,Benedetta Cerretini,Didier Lometet al. Theriogenology, 2022, 189, pp.107-112. ⟨10.1016/j.theriogenology.2022.06.014⟩ Article dans une revue hal-03746194v1
Des protéines de synthèse taillées sur mesure pour investiguer le vivant Vincent Aucagne,Fabienne Burlina,Oleg Melnyk,Vladimir Torbeev L'Actualité Chimique, 2021, 468, pp.26-28 Article dans une revue hal-02959387v1
Enzyme‐Cleavable Linkers for Protein Chemical Synthesis through Solid‐Phase Ligations Skander A Abboud,Mehdi Amoura,J.B Madinier,Brigitte Renoux,Sébastien Papotet al. Angewandte Chemie International Edition, 2021, 60 (34), pp.18612-18618. ⟨10.1002/anie.202103768⟩ Article dans une revue hal-03335485v1
A straightforward methodology to overcome solubility challenges for N-terminal cysteinyl peptide segments used in native chemical ligation Skander A Abboud,Hadji H.,Michel Doudeau,Hélène Bénédetti,Vincent Aucagne Chemical Science, 2021, 12, pp.3194 - 3201. ⟨10.1039/d0sc06001a⟩ Article dans une revue hal-03447239v1
Lanthanide DO3A-Complexes Bearing Peptide Substrates: The Effect of Peptidic Side Chains on Metal Coordination and Relaxivity Sophie Laine,Jean-François Morfin,Mathieu Galibert,Vincent Aucagne,Celia ́ Bonnetet al. Molecules, 2021, 26 (8), pp.2176. ⟨10.3390/molecules26082176⟩ Article dans une revue hal-03437152v1
Monitoring Human Neutrophil Activation by a Proteinase 3 Near-Infrared Fluorescence Substrate-Based Probe Ahlame Saidi,Mylène Wartenberg,J.B Madinier,Guy Ilango,Seda Serenet al. Bioconjugate Chemistry, 2021, 32 (8), pp.1782-1790. ⟨10.1021/acs.bioconjchem.1c00267⟩ Article dans une revue hal-03525228v1
An optimized protocol for the synthesis of N -2-hydroxybenzyl-cysteine peptide crypto-thioesters Skander A. Abboud,Vincent Aucagne Organic & Biomolecular Chemistry, 2020, 18 (40), pp.8199-8208. ⟨10.1039/d0ob01737j⟩ Article dans une revue hal-02975540v1
Structure, function, and evolution of Gga -AvBD11, the archetype of the structural avian-double-β-defensin family Nicolas Guyot,Herve Meudal,Sascha Trapp,Sophie Iochmann,Anne Silvestreet al. Proceedings of the National Academy of Sciences of the United States of America, 2020, 117 (1), pp.337-345. ⟨10.1073/pnas.1912941117⟩ Article dans une revue hal-02522250v1
Thiopurine Derivative-Induced Fpg/Nei DNA Glycosylase Inhibition: Structural, Dynamic and Functional Insights Charlotte Rieux,Stéphane Goffinont,Franck Coste,Zahira Tber,Julien Croset al. International Journal of Molecular Sciences, 2020, 21 (6), pp.2058. ⟨10.3390/ijms21062058⟩ Article dans une revue hal-03082414v1
Near-infrared emitting lanthanide(III) complexes as prototypes of optical imaging agents with peptide targeting ability: a methodological approach Monika Cieslikiewicz-Bouet,Svetlana Eliseeva,Vincent Aucagne,A.F. Delmas,Isabelle Gillaizeauet al. RSC Advances, 2019, 9 (3), pp.1747-1751. ⟨10.1039/c8ra09419e⟩ Article dans une revue hal-02064990v1
The Ancestral N-Terminal Domain of Big Defensins Drives Bacterially Triggered Assembly into Antimicrobial Nanonets Karine Loth,Agnès Vergnes,Cairé Barreto,Sébastien N Voisin,Hervé Meudalet al. mBio, 2019, 10 (5), pii: e01821-19. ⟨10.1128/mBio.01821-19⟩ Article dans une revue hal-02328576v1
Acute and subacute effects of a synthetic kisspeptin analog, C6, on serum concentrations of luteinizing hormone, follicle stimulating hormone, and testosterone in prepubertal bull calves P.A. Parker,E.A. Coffman,K.G. Pohler,J.A. Daniel,V. Aucagneet al. Theriogenology, 2019, 130, pp.111-119. ⟨10.1016/j.theriogenology.2019.03.002⟩ Article dans une revue hal-02088608v1
In silico peptide ligation: Iterative Residue Docking and Linking as a new approach to predict protein-peptide interactions Julien Diharce,Mickaël Cueto,Massimiliano Beltramo,Vincent Aucagne,Pascal Bonnet Molecules, 2019, 24 (7), pp.1-14. ⟨10.3390/molecules24071351⟩ Article dans une revue hal-03525312v1
The kisspeptin analog C6 is a possible alternative to PMSG (pregnant mare serum gonadotropin) for triggering synchronized and fertile ovulations in the Alpine goat Caroline Decourt,Vincent Robert,Didier Lomet,Karine Anger,Marion Georgelinet al. PLoS ONE, 2019, 14 (3), pp.e0214424. ⟨10.1371/journal.pone.0214424⟩ Article dans une revue hal-02088631v1
Imaging of extracellular cathepsin S activity by a selective near infrared fluorescence substrate-based probe Mylène Wartenberg,Ahlame Saidi,Mathieu Galibert,Alix Joulin-Giet,Julien Burlaud-Gaillardet al. Biochimie, 2019, 166, pp.84-93. ⟨10.1016/j.biochi.2019.03.013⟩ Article dans une revue hal-02088627v1
Synthesis of aryl-thioglycopeptides through chemoselective Pd-Mediated conjugation David Montoir,Mehdi Amora,Zine El Abidine Aabasa,Thimmalapura Marulappa Vishwanatha,Expédite Yen-Ponet al. Chemical Science, 2018, 9 (46), pp.8753-8759. ⟨10.1039/C8SC02370K⟩ Article dans une revue hal-02622102v1
Substrate-derived triazolo- and azapeptides as inhibitors of cathepsins K and S Matthieu Galibert,Mylène Wartenberg,Fabien Lecaille,Ahlame Saidi,Sylvie Mavelet al. European Journal of Medicinal Chemistry, 2018, 144, pp.201 - 210. ⟨10.1016/j.ejmech.2017.12.012⟩ Article dans une revue hal-01702303v1
Efficient synthesis of cysteine-rich cyclic peptides through intramolecular native chemical ligation of N-Hnb-Cys peptide crypto-thioesters Victor Terrier,Agnès F. Delmas,Vincent Aucagne Organic & Biomolecular Chemistry, 2017, 15 (2), pp.316 - 319. ⟨10.1039/c6ob02546c⟩ Article dans une revue hal-01618781v1
Spermaurin, an La1-like peptide from the venom of the scorpion Scorpio maurus palmatus , improves sperm motility and fertilization in different mammalian species Guillaume Martinez,Jean-Pascal Hograindleur,Sébastien Voisin,Roland Abi Nahed,Tarek M. Abd El Azizet al. Molecular Human Reproduction, 2017, 23 (2), pp.116-131. ⟨10.1093/molehr/gaw075⟩ Article dans une revue hal-01618630v1
A Helping Hand to Overcome Solubility Challenges in Chemical Protein Synthesis Michael T. Jacobsen,Mark E. Petersen,Xiang Ye,Mathieu Galibert,George H. Lorimeret al. Journal of the American Chemical Society, 2016, 138 (36), pp.11775 - 11782. ⟨10.1021/jacs.6b05719⟩ Article dans une revue hal-01407028v1
A synthetic kisspeptin analog that triggers ovulation and advances puberty Caroline Decourt,Vincent Robert,Karine Anger,Mathieu Galibert,Jean-Baptiste Madinieret al. Scientific Reports, 2016, 6 (1), pp.26908. ⟨10.1038/srep26908⟩ Article dans une revue hal-01406943v1
Native Chemical Ligation Strategy to Overcome Side Reactions during Fmoc-Based Synthesis of C-Terminal Cysteine-Containing Peptides Dominique Lelièvre,Victor P. Terrier,Agnès F. Delmas,Vincent Aucagne Organic Letters, 2016, 18 (5), pp.920 - 923. ⟨10.1021/acs.orglett.5b03612⟩ Article dans une revue hal-01407492v1
A straightforward method for automated Fmoc-based synthesis of bio-inspired peptide crypto-thioesters Victor P. Terrier,Hélène Adihou,Mathieu Arnould,Agnès F. Delmas,Vincent Aucagne Chemical Science, 2016, 7 (1), pp.339 - 345. ⟨10.1039/C5SC02630J⟩ Article dans une revue hal-01407765v1
Complete 1H, 15N and 13C assignment of trappin-2 and 1H assignment of its two domains, elafin and cementoin Karine Loth,Soha Abou Ibrahim Alami,Chahrazed Habès,Solène Garrido,Vincent Aucagneet al. Biomolecular NMR Assignments, 2016, 10 (1), pp.223 - 226. ⟨10.1007/s12104-016-9671-1⟩ Article dans une revue hal-01407495v1
Activation of TRPV2 and BKCa channels by the LL-37 enantiomers stimulates calcium entry and migration of cancer cells. Audrey Gambade,Sami Zreika,Maxime Guéguinou,Igor Chourpa,Gaëlle Fromontet al. Oncotarget, 2016, 7 (17), pp.23785-23800. ⟨10.18632/oncotarget.8122⟩ Article dans une revue hal-01387061v1
Rational Design of Triazololipopeptides Analogs of Kisspeptin Inducing a Long-Lasting Increase of Gonadotropins Massimiliano Beltramo,Vincent Robert,Mathieu Galibert,Jean-Baptiste Madinier,Philippe Marceauet al. Journal of Medicinal Chemistry, 2015, 58 (8), pp.3459-3470. ⟨10.1021/jm5019675⟩ Article dans une revue hal-01170460v1
A mechanically interlocked molecular system programmed for the delivery of an anticancer drug Romain Barat,Thibaut Legigan,I. Tranoy-Opalinski,Brigitte Renoux,Elodie Peraudeauet al. Chemical Science, 2015, 6 (4), pp.2608-2613. ⟨10.1039/c5sc00648a⟩ Article dans une revue hal-03127729v1
Combining triazole ligation and enzymatic glycosylation on solid phase simplifies the synthesis of very long glycoprotein analogues Mathieu Galibert,Véronique Piller,Friedrich Piller,Vincent Aucagne,Agnès F. Delmas Chemical Science, 2015, 6 (6), pp.3617-3623. ⟨10.1039/C5SC00773A⟩ Article dans une revue hal-01178852v1
The nuclear magnetic resonance solution structure of the synthetic AhPDF1.1b plant defensin evidences the structural feature within the γ-motif Fanny Meindre,Dominique Lelièvre,Karine Loth,Oriane Mith,Vincent Aucagneet al. Biochemistry, 2014, 53 (49), pp.7745-54. ⟨10.1021/bi501285k⟩ Article dans une revue hal-01118914v1
Solid phase oxime ligations for the iterative synthesis of polypeptide conjugates Isidore E. Decostaire,Dominique Lelièvre,Vincent Aucagne,Agnès F. Delmas Organic & Biomolecular Chemistry, 2014, 12 (29), pp.5536-5543. ⟨10.1039/c4ob00760c⟩ Article dans une revue hal-01178857v1
Highly efficient solid phase synthesis of large polypeptides by iterative ligations of bis(2-sulfanylethyl)amido (SEA) peptide segments Laurent Raibaut,Hélène Adihou,Rémi Desmet,Agnès F. Delmas,Vincent Aucagneet al. Chemical Science, 2013, 4, pp.4061-4066. ⟨10.1039/c3sc51824h⟩ Article dans une revue hal-00944814v2
A water soluble Cu-I-NHC for CuAAC ligation of unprotected peptides under open air conditions. Christelle Gaulier,Audrey Hospital,Bertrand Legeret,Delmas A.F.,Vincent Aucagneet al. Chemical Communications, 2012, 48, pp.4005-4007 Article dans une revue hal-00711780v1
Initial insights into structure-activity relationships of avian defensins. Chrystelle Derache,Hervé Meudal,Vincent Aucagne,Kevin J Mark,Martine Cadèneet al. Journal of Biological Chemistry, 2012, 287 (10), pp.7746-55. ⟨10.1074/jbc.M111.312108⟩ Article dans une revue hal-00721842v1
Synthesis of a biologically active triazole-containing analogue of cystatin A through successive peptidomimetic alkyne-azide ligations. Ibai E Valverde,Fabien Lecaille,Gilles Lalmanach,Vincent Aucagne,Agnès F Delmas Angewandte Chemie International Edition, 2012, 51 (3), pp.718-22. ⟨10.1002/anie.201107222⟩ Article dans une revue istex hal-00726293v1
Second generation specific-enzyme-activated rotaxane propeptides. Antony Fernandes,Aurélien Viterisi,Vincent Aucagne,David A Leigh,Sébastien Papot Chemical Communications, 2012, 48 (15), pp.2083-5. ⟨10.1039/c2cc17458h⟩ Article dans une revue hal-00678757v1
Towards the simplification of protein synthesis: iterative solid-supported ligations with concomitant purifications. Vincent Aucagne,Ibai E Valverde,Philippe Marceau,Mathieu Galibert,Nabil Dendaneet al. Angewandte Chemie International Edition, 2012, 51 (45), pp.11320-4. ⟨10.1002/anie.201206428⟩ Article dans une revue istex hal-00748170v1
Sulfur-containing amide-based [2]rotaxanes and molecular shuttles Andrea Altieri,Vincent Aucagne,Romen Carrillo,Guy Clarkson,Daniel d'Souzaet al. Chemical Science, 2011, 2 (10), pp.1922. ⟨10.1039/C1SC00335F⟩ Article dans une revue hal-02088663v1
Click a la carte: robust semi-orthogonal alkyne protecting groups for multiple successive azide/alkyne cycloadditions Ibai E. Valverde,Agnès F. Delmas,Vincent Aucagne Tetrahedron, 2009, 65 (36), pp.7597-7602. ⟨10.1016/j.tet.2009.06.093⟩ Article dans une revue istex hal-00525398v1
Primary Structure and Antibacterial Activity of Chicken Bone Marrow-Derived beta-Defensins Chrystelle Derache,Valérie Labas,Vincent Aucagne,Hervé Meudal,Céline Landonet al. Antimicrobial Agents and Chemotherapy, 2009, 53 (11), pp.4647-4655. ⟨10.1128/AAC.00301-09⟩ Article dans une revue hal-00522326v1
Rotaxane-based propeptides: protection and enzymatic release of a bioactive pentapeptide. Anthony Fernandes,Aurélien Viterisi,Frédéric Coutrot,Stéphanie Potok,David A. Leighet al. Angewandte Chemie International Edition, 2009, 48 (35), pp.6443-7. ⟨10.1002/anie.200903215⟩ Article dans une revue hal-00467015v1
Thermodynamics versus kinetics in hetero-Michael cyclizations: a highly stereoselective approach to access both epimers of a C-D-mannopyranoside Vincent Aucagne,A. Tatibouët,Patrick Rollin Tetrahedron Letters, 2008, 49, pp.4750-4753. ⟨10.1016/j.tetlet.2008.05.117⟩ Article dans une revue istex hal-00512453v1
Preparation of peptide thioesters using Fmoc strategy through hydroxyl side chain anchoring Dominique Lelièvre,P. Barta,Vincent Aucagne,A.F. Delmas Tetrahedron Letters, 2008, 49 (25), pp.4016-4019. ⟨10.1016/j.tetlet.2008.04.087⟩ Article dans une revue istex hal-00518141v1
Study of different copper(I) catalysts for the &quot;click chemistry&quot; approach to carbanucleosides J. Broggi,N. Joubert,Vincent Aucagne,T. Zevaco,S. Berteina-Raboinet al. Nucleosides, Nucleotides and Nucleic Acids, 2007, 26, pp.779-783 Article dans une revue hal-00275217v1
Synergic effect of hydride and proton donors in the Pd(0)-mediated deprotection of Nα-Aloc proline derivatives Isidore P. Decostaire,Dominique Lelièvre,Vincent Aucagne,Agnès F. Delmas Tetrahedron Letters, 2007, 48, pp.6523-6526. ⟨10.1016/j.tetlet.2007.07.061⟩ Article dans une revue istex hal-00166600v1
Catalytic &quot;Active-Metal&quot; template synthesis of [2]rotaxanes, [3]rotaxanes, and molecular shuttles, and some observations on the mechanism of the Cu(I)-catalyzed azide-alkyne 1,3-cycloaddition Vincent Aucagne,J. Berna,Jd Crowley,Sm Goldup,Kd Haenniet al. Journal of the American Chemical Society, 2007, 129, pp.11950-11963 Article dans une revue hal-00275210v1
Alkyne-Azide Click Chemistry Mediated Carbanucleosides Synthesis Julie Broggi,Nicolas Joubert,Vincent Aucagne,Sabine Berteina-Raboin,S. Diez-Gonzalezet al. Nucleosides, Nucleotides and Nucleic Acids, 2007, 26 (10-12), pp.1391-1394. ⟨10.1080/15257770701534139⟩ Article dans une revue hal-02086003v1
Rotaxanes of Cyclic Peptides Vincent Aucagne,David Leigh,Julia Lock,Andrew Thomson Journal of the American Chemical Society, 2006, 128 (6), pp.1784-1785. ⟨10.1021/ja057206q⟩ Article dans une revue istex hal-02086005v1
Chemoselective formation of successive triazole linkages in one pot: &quot;click-click&quot; chemistry Vincent Aucagne,David A. Leigh Organic Letters, 2006, 8 (20), pp.4505-4507. ⟨10.1021/ol061657d⟩ Article dans une revue hal-00387909v1
Catalytic “Click” Rotaxanes: A Substoichiometric Metal-Template Pathway to Mechanically Interlocked Architectures Vincent Aucagne,Kevin Hänni,David Leigh,Paul Lusby,D Barney Walker Journal of the American Chemical Society, 2006, 128 (7), pp.2186-2187. ⟨10.1021/ja056903f⟩ Article dans une revue istex hal-02086010v1
Synthesis of 5-haloethynyl- and 5-(1,2-dihalo)vinyluracil nucleosides: Antiviral activity and cellular toxicity Vanessa Escuret,Vincent Aucagne,Nicolas Joubert,David Durantel,Kimberly Rappet al. Bioorganic and Medicinal Chemistry, 2005, 13 (21), pp.6015-6024. ⟨10.1016/j.bmc.2005.06.021⟩ Article dans une revue istex hal-02086013v1
Synthesis and antiviral activity of novel acyclic nucleosides in the 5-alkynyl- and 6-alkylfuro[2,3-d]pyrimidine series Franck Amblard,Vincent Aucagne,Pierre Guenot,Raymond Schinazi,Luigi Agrofoglio Bioorganic and Medicinal Chemistry, 2005, 13 (4), pp.1239-1248. ⟨10.1016/j.bmc.2004.11.057⟩ Article dans une revue istex hal-02086014v1
Highly Efficient AgNO3-Catalyzed Preparation of Substituted Furanopyrimidine Nucleosides [cf. (III)]. Vincent Aucagne,Franck Amblard,Luigi Agrofoglio ChemInform, 2005, 36 (18), ⟨10.1002/chin.200518181⟩ Article dans une revue istex hal-02086027v1
Regioselective Michael-induced cyclisation of γ- and δ-hydroxy vinyl sulfides and vinyl dithiocarbamates V. Aucagne,C. Lorin,A. Tatibouët,P. Rollin Tetrahedron Letters, 2005, 46 (25), pp.4349-4352. ⟨10.1016/j.tetlet.2005.04.112⟩ Article dans une revue istex hal-02086017v1
Palladium-Catalyzed Synthesis of Uridines on Polystyrene-Based Solid Supports Vincent Aucagne,Sabine Berteina-Raboin,Pierre Guenot,Luigi Agrofoglio Journal of Combinatorial Chemistry, 2004, 6 (5), pp.717-723. ⟨10.1021/cc049976o⟩ Article dans une revue hal-02086022v1
Wittig approach to carbohydrate-derived vinyl sulfides, new substrates for regiocontrolled ring-closure reactions Vincent Aucagne,Arnaud Tatibouët,Patrick Rollin Tetrahedron, 2004, 60 (8), pp.1817-1826. ⟨10.1016/j.tet.2003.12.040⟩ Article dans une revue istex hal-02086021v1
Straightforward Synthesis of Labeled and Unlabeled Pyrimidine d4Ns via 2′,3′-Diyne seco Analogues through Olefin Metathesis Reactions Isabelle Gillaizeau,Irene m. Lagoja,Steve p. Nolan,Vincent Aucagne,Jef Rozenskiet al. European Journal of Organic Chemistry, 2003, 2003 (4), pp.666-671. ⟨10.1002/ejoc.200390107⟩ Article dans une revue istex hal-02086029v1
Sulfenic acids in the carbohydrate field. Synthesis of transient glycosulfenic acids and their addition to unsaturated acceptors. Vincent Aucagne,Maria Aversa,Anna Barattucci,Paola Bonaccorsi,Placido Giannettoet al. Journal of Organic Chemistry, 2002, 67 (20), pp.6925-30 Article dans une revue hal-02086034v1
Synthetic Approaches to C-Glucosinolates Vincent Aucagne,David Gueyrard,Arnaud Tatibouët,Alain Quinsac,Patrick Rollin Tetrahedron, 2000, 56 (17), pp.2647-2654. ⟨10.1016/S0040-4020(00)00153-8⟩ Article dans une revue istex hal-02086037v1
the first synthesis of c-glucotropeolin V. Aucagne,D. Gueyrard,A. Tatibout,S. Cottaz,H. Driguezet al. Tetrahedron Letters, 1999, pp.7319-7321 Article dans une revue hal-00309763v1

Communication dans un congrès (39)

Big-Defensin Diversification in Oysters: Implications for Host Defense and Microbiota Management (D. Destoumieux-Garzon INVITED SPEAKER) Noémie de San Nicolas,A. Jouault,Aromal Asokan,Lhousseine Touqui,K Lothet al. IMAP 2024 International Meeting on Antimicrobial Peptides, Sep 2024, Londres, United Kingdom Communication dans un congrès hal-04882843v1
Palladium-mediated S-arylation and S-allylation for late-stage peptide functionalisation and protein conjugation Ross Ballantine,Ameni Hadj Mohamed,Mingxiang Zhu,Aromal Asokan,Linhua Shenet al. 37. European Peptide Symposium. 14. International Peptide Symposium, Aug 2024, Florence, Italy. pp.692-P2.010 Communication dans un congrès hal-05075799v1
Bacteriocyte-specific Cysteine-Rich (BCR) peptides form a new aphid-specific defensin-like family and are promising regulators of aphid symbiosis Hugo Terrasson,Karine Loth,Nicolas Parisot,Françoise Paquet,Isabelle Rahiouiet al. Rencontres du Réseau Ecologie des Interactions Durables (REID), May 2023, Poitiers, France Communication dans un congrès hal-04633283v1
Big defensins: A Diversified Family of Antimicrobial Peptides Confronting Versatile Microbial Environments (DELPHINE DESTOUMIEUX-GARZON INVITED SPEAKER) Noémie de San Nicolas,Aromal Asokan,Rafaela da Rosa,Vincent Aucagne,K. Lothet al. Antimicrobial Peptides. Yesterday, Today, and Tomorrow, Oct 2023, Omaha, Nebraska, USA, United States Communication dans un congrès hal-04885227v1
Les peptides « Bacteriocyte-specific Cystein-Rich » : une nouvelle famille de défensine. Régulateurs de la symbiose chez les pucerons ? Hugo Terrasson,Karine Loth,Nicolas Parisot,Françoise Paquet,Isabelle Rahiouiet al. 9ème Journées du GDR "MultiFonction des Peptides AntiMicrobiens" (MuFoPAM), Oct 2022, Amboise, France Communication dans un congrès hal-04633233v1
Enabling the synthesis of hydrophobic proteins using NCL-labile solubilizing tags: a case study of Crassostrea gigas big defensin 3 A. Asokan,Noémie de San Nicolas,H. Meudal,K. Loth,Delphine Destoumieux-Garzonet al. 22nd GFPP & 5th BPGM French-Belgian Joint Meeting, Groupe Français des Peptides et Protéines, May 2022, Port Leucate, France Communication dans un congrès hal-03976595v1
Peptides « Bacteriocyte-specific Cysteine Rich » (BCR) : un rôle dans le contrôle de la symbiose ? Focus sur BCR4 chez le puceron du pois. Hugo Terrasson,Karine Loth,Nicolas Parisot,Françoise Paquet,Isabelle Rahiouiet al. 12èmes rencontres du réseau français de Biologie Adaptative des Pucerons et Organismes Associés (BAPOA), May 2022, Nice, France Communication dans un congrès hal-04771966v1
Functional DIversification of Big-Defensins and the shaping of oyster microbiota Noémie de San Nicolas,A. Asokan,R.D. Rosa,S.N. Voisin,Marie Agnès Traverset al. AMP 2022 7th International Symposium on Antimicrobial Peptides, Nov 2022, Paris, France Communication dans un congrès hal-03976756v1
Determination of Binding Affinities with Flow-Induced Dispersion Analysis: The Case of Synthetic Affibodies Josef Hamacek,Edina Numanovic,Vincent Aucagne NECTAR, annual meeting, Aug 2021, Lisbon, Portugal Communication dans un congrès hal-03482197v1
A chemical toolbox for simplifying chemical protein synthesis Vincent Aucagne Congrès annuel de la Société Française de Biochimie et Biologie Moléculaire (SFBBM21), Jul 2021, Paris, France Communication dans un congrès hal-03563426v1
Développements méthodologiques pour la synthèse chimique de protéines Vincent Aucagne 33e colloque Biotechnocentre, Oct 2021, Chaumont-sur-Tharonne, France Communication dans un congrès hal-03563421v1
Synthesis of aryl-thioglycopeptides through chemoselective Pd-mediated conjugation David Montoir,Mehdi Amoura,Zine El Abidine Ababsa,T.M. Vishwanatha,Expédite Yen-Ponet al. 4. GFPP Chemical Ligation Meeting (Ligation2020), Jan 2020, Orléans, France Communication dans un congrès hal-02892772v1
”Tag and modify” strategy for the Pd-catalyzed Thioglycoconjugation of peptides D. Montoir,Mehdi Amoura,A. Ababsa Z. E.,M. Vishwanatha T.,E. Yen-Ponet al. Noncanonical amino acids (ncAAs): Tools for biological and biophysical investigations, Oct 2019, Paris, France Communication dans un congrès hal-02892775v1
Gga-AvBD11, the archetype of a new structural family of defensins H. Meudal,Nicolas Guyot,K. Loth,G. Jousset,S. Trappet al. 21e réunion du Groupe Français des Peptides et des Protéines (GFPP21), May 2019, Amboise, France Communication dans un congrès hal-02892790v1
Design of both pseudopeptide inhibitors and imaging probes derived from a unique substrate sequence: a versatile molecular toolbox for studying proteases G. Lalmanach,M. Wartenberg,M. Galibert,A. Saidi,F. Lecailleet al. 21e réunion du Groupe Français des Peptides et des Protéines (GFPP21), May 2019, Amboise, France Communication dans un congrès hal-02892793v1
Développement de bras enzymo-labiles pour la synthèse totale de protéines par ligations chimiques sur support solide S. Abboud,V. Piller,S. Papot,V. Aucagne 32e Colloque Biotechnocentre, Oct 2019, Seillac, France Communication dans un congrès hal-02893386v1
Séminaire invité : Development of a molecular toolbox to simplify the chemical synthesis of proteins Vincent Aucagne Institut de Chimie des Substances Naturelles, Mar 2019, Gif-sur-Yvette, France Communication dans un congrès hal-02974369v1
An improved synthesis of N-Hnb-Cys peptide crypto-thioesters ‒studies on the epimerization of cysteine during solid-phase reductive amination S. Abboud,Mehdi Amoura,V. P. Terrier,A. F. Delmas,V. Aucagne 21e réunion du Groupe Français des Peptides et des Protéines (GFPP21), May 2019, Amboise, France Communication dans un congrès hal-02892784v1
Exploring ancestral traits lost during molecular evolution of Big-Defensins Towards β-defensins (DELPHINE DESTOUMIEUX-GARZON, INVITED SPEAKER) K Loth,Agnès Vergnes,C Barreto,S Voisin,H. Meudalet al. Gordon Research Conference "Antimicrobial Peptides", Feb 2019, Barga, Italy Communication dans un congrès hal-04891216v1
Synthesis and structural characterization of naturally-occuring disulfide rich antimicrobial peptides Gyros Protein Technologies A.F. Delmas,Vincent Aucagne European peptide symposium, Aug 2018, Dublin, Ireland Communication dans un congrès hal-02919154v1
Séminaire invité : Développement d’une boîte à outils pour simplifier la synthèse chimique de protéines Vincent Aucagne Institut des Biomolécules Max Mousseron, Nov 2018, Montpellier, France Communication dans un congrès hal-02974372v1
1ère structure 3D d’une défensine à double motif β-défensine, Gga-AvBD11 du poulet Gallus gallus, et explorations fonctionnelles Nicolas Guyot,Hervé Meudal,Karine Loth,Guillaume Jousset,Anne Silvestreet al. 5es Journées GDR MuFoPAM, Centre National de la Recherche Scientifique (CNRS). FRA., Oct 2018, Paris, France Communication dans un congrès hal-02788993v1
N-2-hydroxybenzyl-cysteine peptide crypto-thioesters for native chemical ligation Mehdi Amoura,D. Sarraf,L. Nauton,V.P. Terrier,D. Lelièvreet al. 35th European Peptide Symposium (EPS35), Aug 2018, Dublin, Ireland Communication dans un congrès hal-02892802v1
Rational design of kisspeptin analogs for the control of reproduction T.M. Vishwanatha,C. Decourt,V.P. Terrier,V. Robert,M. Galibertet al. 4th Belgian Peptide Group Meeting, Feb 2018, Bruxelles, Belgium Communication dans un congrès hal-02892809v1
Fragment covalent docking (FCD) approach: An innovative in silico tools for the prediction of peptide-protein interaction Julien Diharce,Mickaël Cueto,Vincent Aucagne,Massimiliano Beltramo,Pascal Bonnet 256th National Meeting and Exposition of the American-Chemical-Society Nanoscience, Nanotechnology and Beyond (ACS), American Chemical Society (ACS). USA., Aug 2018, Boston, United States. pp.2 Communication dans un congrès hal-02734800v1
A non-chromatographic catch-and-release purification method to simplify the synthesis of cysteine-rich peptides A. Casas-Mora,M. Galibert,A.F. Delmas,V. Aucagne 20e réunion du Groupe Français des Peptides et des Protéines (GFPP 20), Mar 2017, Arcachon, France Communication dans un congrès hal-02893392v1
Séminaire invité : Development of a molecular toolbox to simplify the chemical synthesis of proteins and constrained peptides natural products Vincent Aucagne Vrije Universiteit Brussel, May 2017, Bruxelles, Belgium Communication dans un congrès hal-02974374v1
Simplifier la synthèse totale de protéines et de mini-protéines riches en pont disulfures Vincent Aucagne 7e Symposium Francophone de Synthèse Totale (SFST7), Jun 2017, Orsay, France Communication dans un congrès hal-02892762v1
Séminaire invité : Triazolopeptides as proteolysis-resistant, highly potent KISS1R agonists Vincent Aucagne Universiteit Gent, May 2017, Gand, Belgium Communication dans un congrès hal-02974376v1
Séminaire invité : Development of a molecular toolbox to simplify the chemical synthesis of proteins and constrained peptides natural products Vincent Aucagne Institut Européen de Chimie et Biologie, Apr 2017, Bordeaux, France Communication dans un congrès hal-02974400v1
Séminaire invité : Développement d'une boîte à outils pour simplifier la synthèse chimique de protéines Vincent Aucagne Laboratoire BioCIS - Biomolécules : Conception, Isolement et Synthèse, Université Paris-Sud, Apr 2017, Châtenay-Malabry, France Communication dans un congrès hal-02974390v1
Séminaire invité : Development of a molecular toolbox to simplify the chemical synthesis of proteins. Vincent Aucagne Institut Curie, Jun 2016, Paris, France Communication dans un congrès hal-02974405v1
Séminaire invité : A molecular toolbox for exploring new chemical spaces: making simpler the synthesis of biologically- and therapeutically-relevant small proteins and complex peptides Vincent Aucagne Sanofi, Sep 2016, Francfort, Germany Communication dans un congrès hal-02974403v1
Native Chemical ligation simplifies the access of multidomain antimicrobial peptides: application to the study of big-defensins A.F. Delmas,V.P. Terrier,R.D. Rosa,A. Bressan,P. Marceauet al. International symposium on AntiMicrobial Peptides (AMP2016), Jun 2016, Montpellier, France Communication dans un congrès hal-02892834v1
Design and profiling of new selective KISS1R agonists that stimulate the reproductive system Massimiliano Beltramo,Vincent Aucagne,Vincent Robert,Mathieu Galibert,Jean-Baptiste Madinieret al. 8. International Congress of Neuroendocrinology, Society for Behavioral Neuroendocrinology (SBN). USA., Aug 2014, Sydney, Australia Communication dans un congrès hal-02738894v1
New KISS1R agonists with potential for the treatment of reproductive disorder Massimiliano Beltramo,Vincent Aucagne,Vincent Robert,Mathieu Galibert,Jean-Baptiste Madinieret al. 11. International Symposium on GnRH: The hypothalamic-pituitary-gonadal axis in cancer and reproduction, Kenes International. USA., Feb 2014, Salzburg, Austria Communication dans un congrès hal-02742248v1
Avian beta-defensins in the control of bacterial pathogens of chicken digestive tract Anne-Christine Lalmanach,Chrystelle Derache,Evelyne Esnault,Valérie Labas,V. Aucagneet al. 2. International Symposium on Antimicrobial Peptides. Food Veterinary Medical and Novel Applications, Jun 2009, Saint-Malo, France Communication dans un congrès hal-02751627v1
First insights into the structure-activity relationships of avian beta-defensins. Chrystelle Derache,Hervé Meudal,Vincent Aucagne,Martine Cadène,Agnès Delmaset al. 2nd International Symposium on Antimicrobial Peptides - Food Veterinary Medical and Novel Applications., 2009, Saint-Malo, France Communication dans un congrès hal-02753345v1
PA1b, un peptide à activité insecticide : relations structure/fonction P. da Silva,I. Rahioui,C. Laugier,Yvan Rahbé,A. Delmaset al. XVème Colloque de Physiologie de l'Insecte, 2007, Rennes (France), juillet 2007, France. pp.1-1 Communication dans un congrès hal-00391295v1

Poster de conférence (57)

A semi-synthetic pathway to SUMOylated protein mimics El Hadji Cisse,Pierre Prieu-Serandon,Marcin J Suskiewicz,Vincent Aucagne EMBO Workshop: Ubiquitin and ubiquitin-like proteins in health and disease, Sep 2024, Cavtat & Dubrovnik, Croatia Poster de conférence hal-05217596v1
The aphid BCR4 structure and activity uncover a new defensin peptide superfamily Hugo Terrasson,Karine Loth,Nicolas Parisot,Françoise Paquet,Isabelle Rahiouiet al. XXVII International Congress of Entomology, Aug 2024, Kyoto, Japan Poster de conférence hal-04702878v1
The Bacteriocyte-specific Cysteine-Rich (BCR) proteins: a role in the control of aphid symbiosis ? Hugo Terrasson,Karine Loth,Françoise Paquet,Nicolas Parisot,Isabelle Rahiouiet al. Journée scientifique enjeu « santé globale et bio‐ingénierie » de l'INSA Lyon, Apr 2023, Villeurbanne, France Poster de conférence hal-04633269v1
Bacteriocyte specific Cystein Rich peptides, a new defensin like protein family , are promising regulators of aphid symbiosis Hugo Terrasson,Karine Loth,Nicolas Parisot,Françoise Paquet,Isabelle Rahiouiet al. 10th congress of the International Symbiosis Society (ISS) - 3rd International Conference on Holobionts (joint meeting), Jul 2022, Lyon, France Poster de conférence hal-04771990v1
Role of big-defensins in the control of oyster microbiota Noémie de San Nicolas,A Asokan,S Voisin,A Delmas,Vincent Aucagneet al. 8ème journées du GDR MuFoPAM, Oct 2021, Marseille, France. Poster de conférence hal-04888804v1
Synthesis of N-Hnb-Cys peptide crypto-thioesters: identification of imadozolidinone and epimerized side products, and development of an optimized protocol S. Abboud,A.F. Delmas,V. Aucagne 4th GFPP Chemical Ligation Meeting (Ligation2020), Jan 2020, Orléans, France Poster de conférence hal-02893398v1
Design of GPR54 (Kiss1r) crosslinker peptides: new tools to study G protein-coupled receptors (GPCR) localization and function Vincent Robert,Vishwanatha Thimmalapura Marulappa,Didier Lomet,Caroline Decourt,Laia Miretet al. SNE, Oct 2019, Tours, France Poster de conférence hal-03381932v1
Synthesis of aryl-thioglycopeptides through chemoselective Pd-catalyzed conjugation T.M. Vishwanatha,D. Montoir,Mehdi Amoura,Z. El Ababsa,E. Yen-Ponet al. 21. Réunion du Groupe Français des Peptides et des Protéines (GFPP21), May 2019, Amboise, France Poster de conférence hal-02893488v1
N-Hnb-Cys peptide crypto-thioesters: optimized synthetic protocol and second generation device S. Abboud,Mehdi Amoura,P. Terrier V.,A.F. Delmas,V. Aucagne Noncanonical amino acids (ncAAs): Tools for biological and biophysical investigations, Oct 2019, Paris, France Poster de conférence hal-02893409v1
Chemical synthesis and natural abundance NMR: an efficient tandem to unravel 3D structures of unlabeled disulfide rich peptides Herve Meudal,Françoise Paquet,Laurence Jouvensal,V. Aucagne,A.F. Delmaset al. 21e congrès du Groupe Français des Peptides et des Protéines (GFPP21), May 2019, Amboise, France Poster de conférence hal-02919180v1
Spermaurin, a scorpion venom disulfide-rich miniprotein that improves sperm motility and fertilization in mammals. Françoise Paquet,K. Loth,C. Arnoult,V. Aucagne,A.F. Delmas 21e réunion du Groupe Français des Peptides et des Protéines (GFPP21), May 2019, Amboise, France Poster de conférence hal-02893462v1
Incorporation of trifluoromethylated pseudoproline in an entomotoxic knottin: effects on oxidative folding, 3D structure and biological activity F. Coste,G. Chaume,J.-B. Madinier,I. Rahioui,B. Castainget al. 21e congrès du Groupe Français des Peptides et des Protéines (GFPP), May 2019, Amboise, France Poster de conférence hal-02893471v1
A new structural family for antimicrobial defensins H. Meudal,K. Loth,G. Jousset,V. Aucagne,Nicolas Guyotet al. NMR : a tool for biology XIth, Jan 2019, Paris, France Poster de conférence hal-02919171v1
An improved synthesis of N-Hnb-Cys peptide crypto-thioesters - studies on the epimerization of cysteine during solid-phase reductive amination S. Abboud,Mehdi Amoura,V.P. Terrier,A.F. Delmas,V. Aucagne 8th Chemical Protein Synthesis meeting (CPS2019), Jun 2019, Berlin, Germany Poster de conférence hal-02893426v1
Synthesis of aryl-thioglycopeptides through chemoselective Pd-catalyzed conjugation T.M. Vishwanatha,D. Montoir,Mehdi Amoura,Z. El Ababsa,E. Yen-Ponet al. 26. American Peptide Symposium (APS 2019), Jun 2019, Monterey, Californie, United States Poster de conférence hal-02893419v1
The kisspeptin analog C6 triggers ovulation in non-breeding ewe in the absence of progestogen priming C. Decourt,V. Robert,Didier Lomet,V. Aucagne,Massimiliano Beltramo 9. International Congress of Neuroendocrinology (ICN 2018), Jul 2018, Toronto, Canada Poster de conférence hal-02894264v1
Synthèse chimique et RMN en abondance naturelle : un tandem efficace pour résoudre les structures 3D de peptides/protéines riches en ponts disulfure Françoise Paquet,H. Meudal,Laurence Jouvensal,K. Loth,V. Aucagneet al. 5es journées annuelles du GDR MuFoPAM, Oct 2018, Paris, France Poster de conférence hal-02920025v1
Rational design of kisspeptin analogs for the control of the reproductive system T.M. Vishwanatha,C. Decourt,V.P. Terrier,V. Robert,J.-B. Madinieret al. 25th SCT Young Research Fellows meeting, Mar 2018, Orléans, France Poster de conférence hal-02894277v1
Development of chemo-enzymatic methodologies for the total synthesis of proteins through solid-supported chemical ligation S. Abboud,V. Piller,S. Papot,A.F. Delmas,V. Aucagne 31e Colloque Biotechnocentre, Oct 2018, Seillac, France Poster de conférence hal-02894152v1
Near-infrared emitting lanthanide molecules, macromolecules and nanomaterials: New perspectives of optical biological imaging of living systems S.V. Eliseeva,V. Aucagne,A.F. Delmas,S. Petoud,I. Gillaizeau GDR AIm 2018 - 1ères Journées du GDR AİM: "Agents d'imagerie moléculaire", Jun 2018, Orléans, France Poster de conférence hal-03326661v1
Second generation N-2-hydroxybenzyl-cysteine peptide crypto-thioesters for native chemical ligation Mehdi Amoura,V.P. Terrier,A.F. Delmas,V. Aucagne 35th European Peptide Symposium (EPS35), Aug 2018, Dublin, Ireland Poster de conférence hal-02894157v1
Long-lasting increase of gonadotropins by rational design of lipophilic kisspeptin analogs T.M. Vishwanatha,C. Decourt C,V. Robert,M. Galibert,J.-B. Madinieret al. 2018 International Symposium on Chemical Biology, Jan 2018, Genève, Switzerland Poster de conférence hal-02894282v1
A single injection of compound 6 evoked an LH surge and ovulation in 18 week old gilts R. Cameron,R. Kirkwood,M. Beltramo,V. Aucagne,A. Tilbrook 100th annual meeting of the Endocrine Society (ENDO 2018), Mar 2018, Chicago, Illinois, United States. Endocrine Reviews, 39 (Suppl. 1), pp.281-282, The Endocrine Society’s 100th Annual Meeting and Expo. ⟨10.1093/edrv/39.supp.1⟩ Poster de conférence hal-02894272v1
Design and optimization of alternative thioester precursors to simplify protein synthesis by native chemical ligation Mehdi Amoura,V.P. Terrier,A.F. Delmas,V. Aucagne 25th SCT Young Research Fellows meeting, Mar 2018, Orléans, France Poster de conférence hal-02894273v1
Synthesis of aryl-Thioglycopeptides through chemoselective Pd-catalyzed conjugation David Montoir,Mehdi Amoura,Zine El Abidine Ababsa,Thimmalapura Marulappa Vishwanatha,Expédite Yen-Ponet al. 35 th European Peptide Symposium, Aug 2018, Dublin, Ireland. 2018 Poster de conférence hal-02734043v1
In non-breeding ewes the kisspeptin analog c6 triggers ovulation without progestogen priming Massimiliano Beltramo,Caroline Decourt,Vincent Robert,Didier Lomet,Vincent Aucagne 9th International Congress of Neuroendocrinology, Jul 2018, Toronto, Canada. , 2018, The 9th International Congress of Neuroendocrinology. Abstract book Poster de conférence hal-02735160v1
N-2-Hydroxybenzyl-Cysteine Peptides as Efficient Thioester Surrogates for Native Chemical Ligation Mehdi Amoura,V.P. Terrier,A.F. Delmas,V. Aucagne 4th Belgian Peptide Group Meeting, Feb 2018, Bruxelles, Belgium Poster de conférence hal-02894279v1
Chemical synthesis and natural abundance NMR: An efficient tandem to unravel 3D structures of Disulfide Rich Miniproteins H. Meudal,Laurence Jouvensal,K. Loth,Françoise Paquet,V. Aucagneet al. 35th European Peptide Symposium, Aug 2018, Dublin, Ireland Poster de conférence hal-02920483v1
Incorporation of trifluoromethylated pseudoproline in an entomotoxic knottin: effects on oxidative folding, 3D structure and biological activity F. Coste,G. Chaume,J.-B. Madinier,I. Rahioui,B. Castainget al. 35th European Peptide Symposium (EPS35), Aug 2018, Dublin, Ireland Poster de conférence hal-02894161v1
N-2-Hydroxybenzyl-Cysteine Peptides as Efficient Thioester Surrogates for Native Chemical Ligation Mehdi Amoura,V.P. Terrier,D. Lelièvre,A.F. Delmas,V. Aucagne 25th American Peptide Symposium (APS 25), Jun 2017, Whistler, Canada Poster de conférence hal-02894293v1
Pattern of LH secretion after repeated treatment with kisspeptin analog C6 reveals differential sensitivity between mice and ewes C. Decourt,V. Robert,D. Lomet,Vincent Aucagne,G. Andersonet al. 42. Colloque de la société de neuroendocrinologie (SNE 2017), Sep 2017, Dijon, France Poster de conférence hal-02894288v1
Investigation of tachyphylaxis of LH response following repeated injections of the kisspeptin analog C6 Caroline Decourt,Vincent Robert,Didier Lomet,Karine Anger,A. Delmaset al. Colloque International NeuroFrance 2017, May 2017, Bordeaux, France. 2017, Colloque International NeuroFrance 2017 Poster de conférence hal-01605114v1
NCL-based synthesis, 3D structure and first insight into antimicrobial properties of Cg-BigDef1, an oyster big defensin active at high salinity A. Delmas,K. Loth,Herve Meudal,V. Terrier,R.D. Rosaet al. NMR: a tool for Biology Xth, Jan 2017, Paris, France Poster de conférence hal-02453460v1
Development of highly base-labile linkers for the catch-and-release purification of difficult peptides. Application to Avian beta-defensin 2 N. J. Stanley,D. Lelièvre,A.F. Delmas,Vincent Aucagne 20e congrès annuel du Groupe Français des Peptides et Protéines (GFPP), Mar 2017, Arcachon, France. Poster de conférence hal-02453245v1
Do endogenous kisspeptins and synthetic agonist C6 trigger different intracellular responses? Vincent Robert,Vincent Aucagne,Caroline Decourt,Massimiliano Beltramo 42e colloque de la société de neuroendocrinologie (SNE 2017), Sep 2017, Dijon, France. 2017, 42ème Colloque de la Société de Neuroendocrinologie Poster de conférence hal-02733747v1
Design of a New N-Terminal Linker for the Capture-and-Release Purification of Biologically-Relevant Disulfide-Rich Peptides A. Casas-Mora,M. Galibert,A.F. Delmas,V. Aucagne 25th American Peptide Symposium (APS 25), Jun 2017, Whistler, Canada Poster de conférence hal-02894295v1
NCL-based total synthesis of spermaurin, a scorpion venom disulfide-rich miniprotein that improves sperm motility and fertilization in mammals Vincent Aucagne,E. Schmitt,P. Bulet,C. Arnoult. 20e congrès annuel du Groupe Français des Peptides et Protéines (GFPP), Mar 2017, Arcachon, France. Poster de conférence hal-02453195v1
NCL-based synthesis, 3D structure and first insight into antimicrobial properties of Cg-BigDef1, an oyster big defensin active at high salinity A.F. Delmas,K. Loth,Herve Meudal,V.P. Terrier,R.D. Rosaet al. 20e congrès annuel du Groupe Français des Peptides et Protéines (GFPP), Mar 2017, Arcachon, France Poster de conférence hal-02894301v1
Second generation N-2-hydroxybenzyl-cysteine peptide crypto-thioesters: achieving very fast NCL kinetics at neutral pH Mehdi Amoura,V. P. Terrier,A.F. Delmas,Vincent Aucagne 20e congrès annuel du Groupe Français des Peptides et Protéines (GFPP), Mar 2017, Arcachon, France Poster de conférence hal-02453275v1
Investigation of a kisspeptin analog effects both on synchronization of ovulation and puberty onset in domestic mammals and in rodents Caroline Decourt,Vincent Robert,Didier Lomet,Vincent Aucagne,Greg Andersonet al. ReproSciences 2017, Apr 2017, Tours, France. 75 p., 2017, 2èmes Journées Scientifiques du GdR Repro Poster de conférence hal-01603310v1
N-2-Hydroxybenzyl-Cysteine Peptides as Efficient Thioester Surrogates for Native Chemical Ligation Mehdi Amoura,V.P. Terrier,D. Lelièvre,A.F. Delmas,V. Aucagne 7th Chemical Protein Synthesis meeting (CPS 2017), Sep 2017, Haifa, Israel Poster de conférence hal-02894290v1
Induction of fertile ovulation and puberty advancement by a new kisspeptin analog Caroline Decourt,Vincent Robert,Didier Lomet,Karine Anger,M. Galibertet al. 18th International Congress on Animal Reproduction (ICAR), Jun 2016, Tours, France. 676 p., 2016, 18th International Congress on Animal Reproduction (ICAR) Poster de conférence hal-01604087v1
A capture-and-release purification strategy to simplify the synthesis of disulfide-rich peptides A. Casas-Mora,M. Galibert,A.F. Delmas,V. Aucagne 1st PSL Chemical Biology Meeting, Dec 2016, Paris, France. Poster de conférence hal-02453303v1
A new selective kisspeptin analog, C6, that advance puberty in mice and stimulate fertile ovulation in ewe M. Beltramo,V. Robert,D. Lomet,K. Anger,M. Galibertet al. British Society for Neuroendocrinology Annual Meeting, Sep 2016, Glasgow, United Kingdom Poster de conférence hal-02453336v1
A straightforward strategy for automated Fmoc-based synthesis of peptide “crypto-thioesters”. Application to the total synthesis of biologically-relevant disulfide-rich peptides V. P. Terrier,H. Adihou,D. Lelièvre,Mehdi Amoura,A.F. Delmaset al. Journées de Chimie Organique de la Société Chimique de France (JCO2016), Dec 2016, Palaiseau, France. Poster de conférence hal-02453318v1
Native Chemical ligation simplifies the access of multi-domain antimicrobial peptides: application to the study of big-defensins A.F. Delmas,V.P. Terrier,R.D. Rosa,A. Bressan,P. Marceauet al. 34th European Peptide Symposium 2016 (EPS2016), Sep 2016, Leipzig, Germany Poster de conférence hal-02895296v1
Laligation native simplifie l’étude de l’activité etdu mécanismed’action des peptides antimicrobiens à multiples domaines :cas des Big défensines d’huître. Agnes Vergnes,Victor P. Terrier,Bressan Albert,Rafael Diego Rosa,Vincent Aucagneet al. IIIèmes journées annuelles MuFoPAM « MultiFonction des Peptides AntiMicrobiens », Oct 2016, Tours, France Poster de conférence hal-02128427v1
Rational design of triazolo-lipopeptides analogs of kisspeptin inducing a long-lasting increase of gonadotropins Vincent Aucagne,Vincent Robert,Mathieu Galibert,Jean-Baptiste Madinier,P. Marceauet al. 24. Meeting of the American Peptide Society, Jun 2015, Orlando, United States. 2015, 24th Meeting of the American Peptide Society Poster de conférence hal-02741835v1
Rational design of triazolo-lipopeptides analogs of kisspeptin inducing a long-lasting increase of gonadotrophins Vincent Aucagne,Vincent Robert,Mathieu Galibert,Jean-Baptiste Madinier,P. Marceauet al. 19. Congrès du Groupe Français des Peptides et des Protéines, May 2015, Port-Bail, United States. 2015 Poster de conférence hal-02793091v1
Induction of synchronized fertile ovulation by a new selective agonist of kisspeptin receptor Caroline Decourt,Vincent Robert,Didier Lomet,Karine Anger,Mathieu Galibertet al. 1 Journées du GdR 3606 Repro, Apr 2015, Rennes, France. 105 p., 2015, 1ères Journées Scientifiques du GdR Repro Poster de conférence hal-02742326v1
Development of new kisspeptin analogs to stimulate the reproductive system Caroline Decourt,Karine Anger,Vincent Robert,Vincent Aucagne,Mathieu Galibertet al. International Conference on Gonadotropins & Receptors, Sep 2014, Tours, France. , 2014, ICGRIII International Conference on Gonadotropins & Receptors Poster de conférence hal-02744014v1
Improvement of the chemical production of β-defensins including straightforward attribution of disulfide bridges Mathieu Galibert,Chrystelle Derache,Franck Coste,Hervé Meudal,Anne-Christine Lalmanachet al. 18. Réunion du GFPP, May 2013, Sète, France. 1 p., 2013 Poster de conférence hal-02805308v1
Design and functional profiling of new KISS1R agonists Massimiliano Beltramo,V. Aucagne,Vincent Robert,M. Galibert,J.B. Madinieret al. 2. Annual Meeting of the GDR RCPG-PhysioMed, Oct 2013, Illkirch, France. 2013, 2nd Annual Meeting of the GDR RCPG-PhysioMed Poster de conférence hal-02745908v1
La kisspeptine : une nouvelle voie pour maitriser l’ovulation chez les petits ruminants ? Massimiliano Beltramo,V. Aucagne,R. Vincent,M. Galibert,J.B. Madinieret al. 5. Journées d'Animation Scientifique du département Phase (JAS Phase 2013), Oct 2013, Paris, France. 2013 Poster de conférence hal-02805330v1
Antibacterial spectrum of avian defensin 2: peculiarities in relationship with structural features Chrystelle Derache,Emmanuel Kut,Hervé Meudal,Vincent Aucagne,Agnès Delmaset al. 3. International Symposium on Antimicrobial Peptides: Today knowledge and future applications (AMP 2012), Jun 2012, Lille, France. , pp.D-97, 2012 Poster de conférence hal-02807349v1
Improvement of the chemical production of β-defensins including straighforward attribution of disulfide bridges M. Galibert,Chrystelle Derache,F. Coste,H. Meudal,Anne-Christine Lalmanachet al. 3. International Symposium on Antimicrobial Peptides: Today knowledge and future applications, Jun 2012, Lille, France. , pp.C-43, 2012, AMP 2012 - Antimicrobial peptide symposium Poster de conférence hal-02748134v1
Synthesis and oxidative folding of functional miniproteins containing three disulfide bridges Chrystelle Derache,Hervé Meudal,Vincent Aucagne,Anne-Christine Lalmanach,Céline Landonet al. 21e Colloque Biotechnocentre, 2008, Seillac, France. 1 p, 2008 Poster de conférence hal-02818274v1

Chapitre d'ouvrage (2)

Solid phase chemical ligation S. Abboud,A.F. Delmas,V. Aucagne Brik Ashraf, Dawson Philip, Liu Lei. Total Chemical Protein Synthesis, Wiley, 2021, 978-3-527-34660-8 Chapitre d'ouvrage hal-02974365v1
(9H‐Fluoren‐9‐yl)methanethiol Vincent Aucagne Encyclopedia of Reagents for Organic Synthesis, John Wiley & Sons, Ltd, 2011, ⟨10.1002/047084289X.rn01287⟩ Chapitre d'ouvrage hal-02071829v1

Brevet (3)

Peptides dérivés d'une beta-défensine 11 aviaire et leurs utilisations Nicolas Guyot,Sophie Réhault-Godbert,Anne Silvestre,Sascha Trapp,Sophie Iochmannet al. France, N° de brevet: WO 2020/030773 A1. AMV; SA, 3IMo, AIM. 2020 Brevet hal-02595638v1
KISS1R receptor agonist compounds and use thereof for inducing ovulation in mammals Massimiliano Beltramo,Vincent Aucagne,Alain Caraty,Agnès Delmas,Mathieu Galibert Patent n° : WO2014118318 (A1). 2014, 49 p. + 12 p. annexes Brevet hal-02793004v1
Composés agonistes du récepteur KISS1R et leur utilisation pour induire l’ovulation chez les mammiféres Massimiliano Beltramo,Vincent Aucagne,Alain Caraty,Agnès Delmas N° de brevet: FR3001455 (A1). 2013, 34 p. + 10 p. annexes Brevet hal-02808772v1

Pré-publication, Document de travail (2)

A (poly)Pro tip for preserving native disulfide connectivity during thiol-maleimide bioconjugation of disulfide-rich peptides Lylia Azzoug,Ana Novak,Hervé Meudal,Jean-Baptiste Madinier,Stéphane Charpentieret al. 2025 Pré-publication, Document de travail hal-05376110v1
A straightforward method to prevent the under-estimated problem of aspartimide formation during chemical ligation-mediated protein synthesis El Hadji Cisse,Vincent Aucagne 2024 Pré-publication, Document de travail hal-04797697v1