William Raoul CRHC Inserm

Présentation

Parcours scientifique

2017 : Habilitation à Diriger des Recherches, Sciences de la Vie et de la Santé, Oncologie Digestive, Université François Rabelais de Tours.

2009 : Concours CR2, CSS1 Inserm, Neurosciences.

2005 : Doctorat de Sciences de la Vie et de la Santé, Toxicologie Pulmonaire, Université Paris XII-Créteil.

2001 : Diplôme d'études approfondies, Toxicologie Générale, Université Paris V-Descartes.

2000 : Maîtrise de Biologie Cellulaire et Physiologie Animale, Université Paris XII-Créteil.

Laboratoires

2019- : Inserm UMR 1069 N2C/N2COx, Niche Nutrition Cancer et Métabolisme Oxydatif, Université de Tours

Directeur d’unité : Pr Christophe Vandier

2018-2019 : équipe Pharmacologie des anticorps chez l'Homme, PATCH, EA7501, Université de Tours

Directeur d’équipe : Pr Gilles Paintaud

2013-2017 : CNRS UMR 7292 GICC, Génétique Immunothérapie Chimie Cancer, Université François Rabelais, Tours

Directeur d’unité : Pr Gilles Paintaud

2012-2013 : équipe S14, INSERM UMR S 968, Institut de la Vision, Paris

Directeur d’équipe : Dr Florian Sennlaub

2009-2011 : équipe 21, INSERM UMR S 872, Centre de Recherche des Cordeliers, Paris

Directeur d’équipe : Dr Florian Sennlaub

2006-2008 : équipe 17, INSERM UMR S 872, Centre de Recherche des Cordeliers, Paris

Directeur d’équipe : Pr Francine Behar-Cohen

2001-2005 : INSERM U651 (ex-U492), Faculté de Médecine, Créteil

Directeur de thèse de doctorat : Pr Bernard Maitre / Directeur d’unité : Pr Serge Adnot

Publications

Article dans une revue (52)

Evaluation of serum mid-infrared spectroscopy as new prognostic marker for first-line bevacizumab-based chemotherapy in metastatic colorectal cancer Romain Chautard,Morgane Caulet,Olivier Bouché,Christophe Borg,Sylvain Manfrediet al. Digestive and Liver Disease, 2025, 57 (1), pp.141 - 148. ⟨10.1016/j.dld.2024.07.022⟩ Article dans une revue hal-04888278v1
Synthesis and biological evaluation of new tri-heterocyclic derivatives as anti-colorectal cancer agents Benjamin Victoir,Océane Pertegaz,Elfi Ducrocq,Marion Polomski,Maxime Guéguinouet al. Results in Chemistry, 2025, 13, pp.102015. ⟨10.1016/j.rechem.2024.102015⟩ Article dans une revue hal-04887868v1
Delivery of Anticancer Drugs Using Microbubble-Assisted Ultrasound in a 3D Spheroid Model Marie Roy,Corentin Alix,Julien Burlaud-Gaillard,Damien Fouan,William Raoulet al. Molecular Pharmaceutics, 2024, Online ahead of print. ⟨10.1021/acs.molpharmaceut.3c00921⟩ Article dans une revue inserm-04374054v1
MICU2 up-regulation enhances tumor aggressiveness and metabolic reprogramming during colorectal cancer development Alison Robert,David Crottès,Jérôme Bourgeais,Naig Gueguen,Arnaud Chevrollieret al. PLoS Biology, 2024, 22 (10), pp.e3002854. ⟨10.1371/journal.pbio.3002854⟩ Article dans une revue hal-04887845v1
Fe3O4-Based Magnetic Nanoprobes for miRNA-484 Capture in Human Serum: Implications for Colorectal Cancer Screening Iveta Vilímová,Stephanie David,Clément Vigouroux,William Raoul,Laetitia Corsetet al. ACS Applied Nano Materials, 2024, 7 (8), pp.8854-8861. ⟨10.1021/acsanm.4c00334⟩ Article dans une revue hal-04660868v1
Curcumin and NCLX inhibitors share anti-tumoral mechanisms in microsatellite-instability-driven colorectal cancer Maxime Guéguinou,Sajida Ibrahim,Jérôme Bourgeais,Alison Robert,Trayambak Pathaket al. Cellular and Molecular Life Sciences, 2022, 79 (6), pp.article n° 284. ⟨10.1007/s00018-022-04311-4⟩ Article dans une revue hal-03668944v1
Calcium signaling: A therapeutic target to overcome resistance to therapies in cancer Olivier Romito,Maxime Guéguinou,William Raoul,Ophélie Champion,Alison Robertet al. Cell Calcium, 2022, 108, pp.102673. ⟨10.1016/j.ceca.2022.102673⟩ Article dans une revue inserm-03884267v1
SK4 oncochannels regulate calcium entry and promote cell migration in KRAS-mutated colorectal cancer Sajida Ibrahim,Justine Chaigne,Hassan Dakik,Yann Fourbon,Laetitia Corsetet al. Cell Calcium, 2021, 96, pp.102384. ⟨10.1016/j.ceca.2021.102384⟩ Article dans une revue inserm-03158756v1
Panitumumab and cetuximab affect differently miRNA expression in colorectal cancer cells Romain Chautard,Laetitia Corset,Sajida Ibrahim,Céline Desvignes,Gilles Paintaudet al. Biomarkers in Medicine, 2021, Online ahead of print. ⟨10.2217/bmm-2020-0520⟩ Article dans une revue inserm-03272360v1
New Quinoxaline Derivatives as Dual Pim-1/2 Kinase Inhibitors: Design, Synthesis and Biological Evaluation Bruno Oyallon,Marie Brachet-Botineau,Cédric Logé,Thomas Robert,Stéphane Bachet al. Molecules, 2021, 26 (4), pp.867. ⟨10.3390/molecules26040867⟩ Article dans une revue inserm-03272339v1
A robust enzyme-linked immunosorbent assay to measure serum ramucirumab concentrations Celine Desvignes,David Ternant,Thierry Lecomte,Astrid Lièvre,Marc Ohresseret al. Bioanalysis, 2021, 13 (7), pp.565-574. ⟨10.4155/bio-2020-0199⟩ Article dans une revue inserm-03186974v1
CD36 Deficiency Inhibits Retinal Inflammation and Retinal Degeneration in Cx3cr1 Knockout Mice Sophie Lavalette,Sara Touhami,Christophe Roubeix,Marianne Houssier,Sébastien Augustinet al. Frontiers in Immunology, 2020, 1, ⟨10.3389/fimmu.2019.03032⟩ Article dans une revue hal-02438587v1
Concurrent losses of skeletal muscle mass, adipose tissue and bone mineral density during bevacizumab / cytotoxic chemotherapy treatment for metastatic colorectal cancer Adeline Dolly,Thierry Lecomte,Olivier Bouché,Christophe Borg,Eric Terrebonneet al. Clinical Nutrition, 2020, S0261-5614 (20), pp.30080-7. ⟨10.1016/j.clnu.2020.02.017⟩ Article dans une revue inserm-02735513v1
Potassium and Calcium Channel Complexes as Novel Targets for Cancer Research Marie Potier-Cartereau,William Raoul,Günther Weber,Karine Mahéo,Raphaël Rapetti-Mausset al. Reviews of Physiology Biochemistry and Pharmacology, 2020, Epub 2020 - 08 August. ⟨10.1007/112_2020_24⟩ Article dans une revue inserm-02921492v1
Enhancing Nab-Paclitaxel Delivery Using Microbubble-Assisted Ultrasound in a Pancreatic Cancer Model Diane Bressand,Anthony Novell,Alban Girault,William Raoul,Gaëlle Fromont-Hankardet al. Molecular Pharmaceutics, 2019, 16 (9), pp.3814-3822. ⟨10.1021/acs.molpharmaceut.9b00416⟩ Article dans une revue hal-02301225v1
micro-ARN et cancer colorectal Romain Chautard,Sajida Ibrahim,Maxime Gueguinou,Thierry Lecomte,William Raoul Hépato-Gastro & Oncologie Digestive, 2019, ⟨10.1684/hpg.2019.1896⟩ Article dans une revue hal-02438640v1
Expression Profiling of Calcium Channels and Calcium-Activated Potassium Channels in Colorectal Cancer Sajida Ibrahim,Hassan Dakik,Christophe Vandier,Romain Chautard,Gilles Paintaudet al. Cancers, 2019, 11 (4), pp.561. ⟨10.3390/cancers11040561⟩ Article dans une revue inserm-02152189v1
Mo-derived perivascular macrophage recruitment protects against endothelial cell death in retinal vein occlusion Christophe Roubeix,Elisa Dominguez,William Raoul,Xavier Guillonneau,Michel Paqueset al. Journal of Neuroinflammation, 2019, 16 (1), ⟨10.1186/s12974-019-1547-8⟩ Article dans une revue inserm-02279956v1
Influence of Antigen Mass on the Pharmacokinetics of Therapeutic Antibodies in Humans David Ternant,Nicolas Azzopardi,William Raoul,Theodora Bejan-Angoulvant,Gilles Paintaud Clinical Pharmacokinetics, In press, ⟨10.1007/s40262-018-0680-3⟩ Article dans une revue hal-01821717v1
Pharmacokinetics partly explains the relationship between carcinoembryonic antigen level and survival of colorectal cancer patients treated with ramucirumab Sajida Ibrahim,William Raoul,Thierry Lecomte,Gilles Paintaud,David Ternant European Journal of Cancer, 2018, 92, pp.119 - 120. ⟨10.1016/j.ejca.2017.12.004⟩ Article dans une revue inserm-01755511v1
Méthodes d'évaluation de la cicatrisation muqueuse des maladies inflammatoires chroniques de l'intestin (MICI) Julie Auzoux,Gilles Boschetti,Widad Lahlou,Alexandre Aubourg,Alban Giraultet al. Hépato-Gastro & Oncologie Digestive, 2017 Article dans une revue hal-02438672v1
Drug Efficacy Monitoring in Pharmacotherapy of Multiple Sclerosis with Biological Agents Marzia Caldano,William Raoul,Theo Rispens,Antonio Bertolotto Therapeutic Drug Monitoring, 2017, 39 (4), pp.350 - 355. ⟨10.1097/FTD.0000000000000393⟩ Article dans une revue inserm-01755556v1
Complement Factor H Inhibits CD47-Mediated Resolution of Inflammation Bertrand Calippe,Sébastien Augustin,Fanny Beguier,Hugo Charles-Messance,Lucie Poupelet al. Immunity, 2017, 46 (2), pp.261 - 272. ⟨10.1016/j.immuni.2017.01.006⟩ Article dans une revue inserm-01755551v1
Monoclonal Antibodies Targeting the IL-17/IL-17RA Axis: An Opportunity to Improve the Efficiency of Anti-VEGF Therapy in Fighting Metastatic Colorectal Cancer? Sajida Ibrahim,Alban Girault,Marc Ohresser,Emilie Lereclus,Gilles Paintaudet al. Clinical Colorectal Cancer, 2017, ⟨10.1016/j.clcc.2017.10.003⟩ Article dans une revue inserm-01661759v1
Association of choroidal IL-17-producing T lymphocytes and macrophages with geographic atrophy Serge Camelo,Sophie Lavalette,Xavier Guillonneau,William Raoul,Florian Sennlaub Ophthalmologica, 2016, 236 (1), pp.53-58. ⟨10.1159/000446587⟩ Article dans une revue inserm-01499605v1
A possible association of baseline serum IL-17A concentrations with progression-free survival of metastatic colorectal cancer patients treated with a bevacizumab-based regimen Emilie Lereclus,Mira Tout,Alban Girault,Nadine Baroukh,Morgane Cauletet al. BMC Cancer, 2016, 17 (1), pp.220. ⟨10.1186/s12885-017-3210-z⟩ Article dans une revue inserm-01661765v1
Experimental Branch Retinal Vein Occlusion Induces Upstream Pericyte Loss and Vascular Destabilization Elisa Dominguez,William Raoul,Bertrand Calippe,José-Alain Sahel,Xavier Guillonneauet al. PLoS ONE, 2015, 10 (7), pp.e0132644. ⟨10.1371/journal.pone.0132644.g006⟩ Article dans une revue inserm-01231103v1
Protease nexin-1 regulates retinal vascular development Sonia Selbonne,Deborah Francois,William Raoul,Yacine Boulaftali,Florian Sennlaubet al. Cellular and Molecular Life Sciences, 2015, 72 (20), pp.3999-4011. ⟨10.1007/s00018-015-1972-5⟩ Article dans une revue inserm-01231082v1
APOE Isoforms Control Pathogenic Subretinal Inflammation in Age-Related Macular Degeneration Olivier Levy,Sophie Lavalette,Shulong Hu,Michael Housset,William Raoulet al. Journal of Neuroscience, 2015, 35 (40), pp.13568-13576. ⟨10.1523/JNEUROSCI.2468-15.2015⟩ Article dans une revue hal-02301206v1
Thinning of the RPE and choroid associated with T lymphocyte recruitment in aged and light-challenged mice Serge Camelo,Bertrand Calippe,Sophie Lavalette,Elisa Dominguez,Justine Huret al. Molecular Vision, 2015, 21, pp.1051-9 Article dans une revue inserm-01231077v1
Apolipoprotein E promotes subretinal mononuclear phagocyte survival and chronic inflammation in age-related macular degeneration Olivier Levy,Bertrand Calippe,Sophie Lavalette,Shulong J Hu,William Raoulet al. EMBO Molecular Medicine, 2015, 7 (2), pp.211-26. ⟨10.15252/emmm.201404524⟩ Article dans une revue inserm-01231055v1
Spectral-domain optical coherence tomography of the rodent eye: highlighting layers of the outer retina using signal averaging and comparison with histology. Adeline Berger,Sophie Cavallero,Elisa Dominguez,Peggy Barbe,Manuel Simonuttiet al. PLoS ONE, 2014, 9 (5), pp.e96494. ⟨10.1371/journal.pone.0096494⟩ Article dans une revue hal-00990132v1
CCR2(+) monocytes infiltrate atrophic lesions in age-related macular disease and mediate photoreceptor degeneration in experimental subretinal inflammation in Cx3cr1 deficient mice. Florian Sennlaub,Constance Auvynet,Bertrand Calippe,Sophie Lavalette,Lucie Poupelet al. EMBO Molecular Medicine, 2013, 5 (11), pp.1775-93. ⟨10.1002/emmm.201302692⟩ Article dans une revue inserm-00912837v1
Neonatal Hyperglycemia Inhibits Angiogenesis and Induces Inflammation and Neuronal Degeneration in the Retina Elsa Kermorvant-Duchemin,Alexis Christophe Pinel,Sophie Lavalette,Delphine Lenne,William Raoulet al. PLoS ONE, 2013, 8 (11), pp.e79545. ⟨10.1371/journal.pone.0079545⟩ Article dans une revue hal-02301188v1
Comment on &quot;Ccl2, Cx3cr1 and Ccl2/Cx3cr1 chemokine deficiencies are not sufficient to cause age-related retinal degeneration&quot; by Luhmann et al. (Exp. Eye Res. 2013; 107: 80.doi: 10.1016). Christophe Combadière,William Raoul,Xavier Guillonneau,Florian Sennlaub Experimental Eye Research, 2013, 111, pp.134-5. ⟨10.1016/j.exer.2013.02.002⟩ Article dans une revue inserm-00990798v1
MFGE8 Does Not Influence Chorio-Retinal Homeostasis or Choroidal Neovascularization in vivo. William Raoul,Lucie Poupel,David-Alexandre Tregouet,Sophie Lavalette,Serge Cameloet al. PLoS ONE, 2012, 7 (3), pp.e33244. ⟨10.1371/journal.pone.0033244⟩ Article dans une revue inserm-00690728v1
Delta-like 4 inhibits choroidal neovascularization despite opposing effects on vascular endothelium and macrophages. Serge Camelo,William Raoul,Sophie Lavalette,Bertrand Calippe,Brunella Cristofaroet al. Angiogenesis, 2012, 15 (4), pp.609-22. ⟨10.1007/s10456-012-9290-0⟩ Article dans une revue inserm-00853034v1
Interleukin-1β inhibition prevents choroidal neovascularization and does not exacerbate photoreceptor degeneration. Sophie Lavalette,William Raoul,Marianne Houssier,Serge Camelo,Olivier Levyet al. American Journal of Pathology, 2011, 178 (5), pp.2416-23. ⟨10.1016/j.ajpath.2011.01.013⟩ Article dans une revue inserm-00690746v1
Rôles des chimiokines dans le développement de la dégénérescence maculaire liée à l’âge William Raoul,Elise C. Lelièvre,Constance Auvynet,Charles Feumi,Christophe Combadièreet al. Biologie Aujourd'hui, 2010, 204 (4), pp.311-319. ⟨10.1051/jbio/2010024⟩ Article dans une revue istex hal-02301154v1
CCL2/CCR2 and CX3CL1/CX3CR1 chemokine axes and their possible involvement in age-related macular degeneration. William Raoul,Constance Auvynet,Serge Camelo,Xavier Guillonneau,Charles Feumiet al. Journal of Neuroinflammation, 2010, 7, pp.87. ⟨10.1186/1742-2094-7-87⟩ Article dans une revue inserm-00610572v2
Toxoplasma gondii: Flat-mounting of retina as a new tool for the observation of ocular infection in mice Patricia Escoffier,Jean-Claude Jeanny,Carine Marinach-Patrice,Laurent Jonet,William Raoulet al. Experimental Parasitology, 2010, pp.259-262. ⟨10.1016/j.exppara.2010.04.006⟩ Article dans une revue inserm-01094666v1
CD36 Deficiency Leads to Choroidal Involution via COX2 Down-Regulation in Rodents. Marianne Houssier,William Raoul,Sophie Lavalette,Nicole Keller,Xavier Guillonneauet al. PLoS Medicine, 2008, 5 (2), pp.e39. ⟨10.1371/journal.pmed.0050039⟩ Article dans une revue inserm-00258554v1
Netrin-4 inhibits angiogenesis via binding to neogenin and recruitment of Unc5B. Esma Lejmi,Laurence Leconte,Sandrine Pédron-Mazoyer,Stanislas Ropert,William Raoulet al. Proceedings of the National Academy of Sciences of the United States of America, 2008, 105 (34), pp.12491-6. ⟨10.1073/pnas.0804008105⟩ Article dans une revue inserm-00315946v1
Role of the chemokine receptor CX3CR1 in the mobilization of phagocytic retinal microglial cells. William Raoul,Nicole Keller,Mathieu Rodéro,Francine Behar-Cohen,Florian Sennlaubet al. Journal of Neuroimmunology, 2008, 198 (1-2), pp.56-61. ⟨10.1016/j.jneuroim.2008.04.014⟩ Article dans une revue inserm-00311574v1
Lipid-bloated subretinal microglial cells are at the origin of drusen appearance in CX3CR1-deficient mice. William Raoul,Charles Feumi,Nicole Keller,Sophie Lavalette,Marianne Houssieret al. Ophthalmic Research, 2008, 40 (3-4), pp.115-9. ⟨10.1159/000119860⟩ Article dans une revue inserm-00315944v1
Polymorphism in the Microglial Cell-Mobilizing CX3CR1 Gene Is Associated With Survival in Patients With Glioblastoma Mathieu Rodéro,Yannick Marie,Mathieu Coudert,Emmeline Blondet,Karima Mokhtariet al. Journal of Clinical Oncology, 2008, 26 (36), pp.5957-5964. ⟨10.1200/JCO.2008.17.2833⟩ Article dans une revue hal-02301138v1
Effects of bone marrow-derived cells on monocrotaline- and hypoxia-induced pulmonary hypertension in mice. William Raoul,Orianne Wagner-Ballon,Guitanouch Saber,Anne Hulin,Elisabeth Marcoset al. Respiratory Research, 2007, 8, pp.8. ⟨10.1186/1465-9921-8-8⟩ Article dans une revue inserm-00130570v1
CX3CR1-dependent subretinal microglia cell accumulation is associated with cardinal features of age-related macular degeneration. Christophe Combadière,Charles Feumi,William Raoul,Nicole Keller,Mathieu Rodéroet al. Journal of Clinical Investigation, 2007, 117 (10), pp.2920-2928. ⟨10.1172/JCI31692⟩ Article dans une revue inserm-00176389v1
Serotonin transporter inhibition prevents and reverses monocrotaline-induced pulmonary hypertension in rats. Christophe Guignabert,Bernadette Raffestin,Rima Benferhat,William Raoul,Patricia Zadigueet al. Circulation, 2005, 111 (21), pp.2812-9. ⟨10.1161/CIRCULATIONAHA.104.524926⟩ Article dans une revue inserm-00499643v1
Effects of vascular endothelial growth factor on isolated fetal alveolar type II cells William Raoul,Bernadette Chailley-Heu,Anne-Marie Barlier-Mur,Christophe Delacourt,Bernard Maitreet al. American Journal of Physiology - Lung Cellular and Molecular Physiology, 2004, 286 (6), pp.L1293 - L1301. ⟨10.1152/ajplung.00157.2003⟩ Article dans une revue inserm-01755344v1
Adenovirus-mediated fibroblast growth factor 1 expression in the lung induces epithelial cell proliferation: consequences to hyperoxic lung injury in rats. Vanessa Louzier,William Raoul,Aude Leroux,Didier Branellec,Jean-Michel Caillaudet al. Human Gene Therapy, 2004, 15 (8), pp.793-804. ⟨10.1089/1043034041648390⟩ Article dans une revue inserm-00990784v1
Lung Overexpression of Angiostatin Aggravates Pulmonary Hypertension in Chronically Hypoxic Mice Marie-Aude Pascaud,Frank Griscelli,William Raoul,Elisabeth Marcos,Paule Opolonet al. American Journal of Respiratory Cell and Molecular Biology, 2003, 29, pp.449 - 457. ⟨10.1165/rcmb.2002-0120OC⟩ Article dans une revue inserm-01094673v1

Pré-publication, Document de travail (6)

Integrative analysis of circulating biomarkers of colorectal cancer combining mid-infrared spectroscopy and targeted metabolomics Valérie Monbet,William Raoul,Patrick Emond,Maxime Guéguinou,Antoine Lefèvreet al. 2025 Pré-publication, Document de travail hal-05448677v1
Synthesis and Biological Evaluation of New Inhibitors of Jak/Stat Pathway in Colorectal Cancer Benjamin Victoir,Océane Pertegaz,Elfi Ducrocq,Marion Polomski,Maxime Guéguinouet al. 2026 Pré-publication, Document de travail hal-05448634v1
Encoding of the colorectal cancer metabolic program through MICU2 Alison Robert,David Crottès,Jérôme Bourgeais,Naïg Gueguen,Arnaud Chevrollieret al. 2026 Pré-publication, Document de travail hal-05448690v1
Curcumin and NCLX Inhibitors Share Anti-Tumoral Mechanisms in Microsatellite-Instability-Driven Colorectal Cancer Maxime Guéguinou,Sajida Ibrahim,Jérôme Bourgeais,Alison Robert,Trayambak Pathaket al. 2022 Pré-publication, Document de travail hal-05448749v1
Evaluation of lung VEGF-A transduction during hyperoxia-induced injury in rats William Raoul,Vanessa Louzier,Saadia Eddahibi,Serge Adnot,Bernard Maitreet al. 2026 Pré-publication, Document de travail hal-05448702v1
Single-Dose Monocrotaline Pyrrole Injection as a Model of Pulmonary Endothelial Injury In Mice William Raoul,Anne Hulin,Guitanouch Saber,Catherine Boisnier,Saadia Eddahibiet al. 2026 Pré-publication, Document de travail hal-05448710v1

Thèse (1)

Effets des facteurs angiogéniques et des cellules progénitrices dans la réparation de la barrière alvéolo-capillaire au cours des agressions pulmonaires aiguës William Raoul Sciences du Vivant [q-bio]. Université Paris XII Créteil, 2005. Français. ⟨NNT : ⟩ Thèse tel-05449212v1