Xavier Prieur

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Publications

Proteomic Signature of Liver Injury Across the Spectrum of Insulin Resistance

Xavier Prieur , Dominique Langin

Journal of Clinical Endocrinology and Metabolism, 2025, ⟨10.1210/clinem/dgaf627⟩

Article dans une revue hal-05582695v1
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Seipin Governs caveolin-1 trafficking through modulating sphingolipid-glycerolipid balance

Maxime Carpentier , Mohyeddine Omrane , Rola Shaaban , Jennica Träger , Naïma El Khallouki et al.

Cell Reports, 2025, 44 (10), pp.116320. ⟨10.1016/j.celrep.2025.116320⟩

Article dans une revue hal-05369874v1

Efficacy of Semaglutide as Adjuvant Treatment for Sleeve Gastrectomy: A Proof‐of‐Concept Study in Mice

Samuel Frey , Clément Louis-Gaubert , Amélie Thouzeau , Lola Cossé , Victoria Lorant et al.

Obesity, 2025, 33 (11), pp.2061-2066. ⟨10.1002/oby.70003⟩

Article dans une revue hal-05387547v1

Multimodal imaging reveals distinct cardiac benefits of dulaglutide versus dapagliflozin in a mouse model of glucotoxic cardiomyopathy

Michael Joubert , Simon Ducheix , Xavier Prieur , Bertrand Cariou , Alain Manrique

Diabetes, Obesity and Metabolism, 2025, 27 (11), pp.6748-6752. ⟨10.1111/dom.70012⟩

Article dans une revue hal-05409795v1
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Beta-cell adaptation unveiled: The role of myokines in insulin-resistant mice

Alexandrine Liboz , Carine Beaupère , Natacha Roblot , Emma Rousseau , Jean-Yves Tinevez et al.

Cell Reports, 2025, 44 (9), pp.116283. ⟨10.1016/j.celrep.2025.116283⟩

Article dans une revue pasteur-05264583v1
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Generalized lipodystrophies: Clinical characterization and physiopathology

Xavier Prieur

Annales d'Endocrinologie = Annals of Endocrinology, 2024, 85 (3), pp.195-196. ⟨10.1016/j.ando.2024.05.017⟩

Article dans une revue hal-04876513v1
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Empagliflozin mitigates metabolic dysfunction‐associated steatotic liver disease by reducing de novo lipogenesis in a mouse model of lipoatrophic diabetes

Sarra Smati , Thibaud Sotin , Perrine Deniel , Simon Ducheix , Michael Joubert et al.

Diabetes, Obesity and Metabolism, 2024, 26 (8), pp.3466-3470. ⟨10.1111/dom.15634⟩

Article dans une revue hal-04797985v1
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Extracellular vesicles are carriers of adiponectin with insulin-sensitizing and anti-inflammatory properties

Alexia Blandin , Jérémy Amosse , Josy Froger , Gregory Hilairet , Maëva Durcin et al.

Cell Reports, 2023, 42 (8), pp.112866. ⟨10.1016/j.celrep.2023.112866⟩

Article dans une revue hal-04198014v1
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Seipin Deficiency as a Model of Severe Adipocyte Dysfunction: Lessons from Rodent Models and Teaching for Human Disease

Jocelyne Magré , Xavier Prieur

International Journal of Molecular Sciences, 2022, 23 (2), pp.740. ⟨10.3390/ijms23020740⟩

Article dans une revue hal-04591822v1
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Nutritional biomarkers and heart failure requiring hospitalization in patients with type 2 diabetes: the SURDIAGENE cohort

Matthieu Wargny , Mikaël Croyal , Stéphanie Ragot , Elise Gand , David Jacobi et al.

Cardiovascular Diabetology, 2022, 21 (1), pp.101. ⟨10.1186/s12933-022-01505-9⟩

Article dans une revue hal-03869068v1
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PiT2 deficiency prevents increase of bone marrow adipose tissue during skeletal maturation but not in OVX-induced osteoporosis

Giulia Frangi , Marie Guicheteau , Frederic Jacquot , Grzegorz Pyka , Greet Kerckhofs et al.

Frontiers in Endocrinology, 2022, 13, ⟨10.3389/fendo.2022.921073⟩

Article dans une revue hal-03899764v1
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Seipin localizes at endoplasmic-reticulum-mitochondria contact sites to control mitochondrial calcium import and metabolism in adipocytes

Yoann Combot , Veijo T. Salo , Gilliane Chadeuf , Maarit Hölttä , Katharina Ven et al.

Cell Reports, 2022, 38 (2), pp.110213. ⟨10.1016/j.celrep.2021.110213⟩

Article dans une revue hal-03534214v1
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Not Enough Fat: Mouse Models of Inherited Lipodystrophy

Soazig Le Lay , Jocelyne Magré , Xavier Prieur

Frontiers in Endocrinology, 2022, 13, pp.785819. ⟨10.3389/fendo.2022.785819⟩

Article dans une revue hal-04590859v1
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Proceedings of the annual meeting of the European Consortium of Lipodystrophies (ECLip) Cambridge

Héléna Mosbah , Baris Akinci , David Araújo-Vilar , Juan Carrion Tudela , Giovanni Ceccarini et al.

Annales d'Endocrinologie = Annals of Endocrinology, 2022, 83 (6), pp.461-468. ⟨10.1016/j.ando.2022.07.674⟩

Article dans une revue hal-03944016v1
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PCSK9 is not secreted from mature differentiated intestinal cells

François Moreau , Aurélie Thédrez , Damien Garçon , Audrey Ayer , Thibaud Sotin et al.

Journal of Lipid Research, 2021, 62, pp.100096. ⟨10.1016/j.jlr.2021.100096⟩

Article dans une revue hal-03350100v1
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PCSK9 regulates the NODAL signaling pathway and cellular proliferation in hiPSCs

Meryl Roudaut , Salam Idriss , Amandine Caillaud , Aurore Girardeau , Antoine Rimbert et al.

Stem Cell Reports, 2021, ⟨10.1016/j.stemcr.2021.10.004⟩

Article dans une revue hal-03451184v1
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Retinyl esters form lipid droplets independently of triacylglycerol and seipin

Martijn R Molenaar , Kamlesh K Yadav , Alexandre Toulmay , Tsjerk A Wassenaar , Muriel C Mari et al.

Journal of Cell Biology, 2021, 220 (10), pp.e202011071. ⟨10.1083/jcb.202011071⟩

Article dans une revue hal-03336168v1
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Circulating Rather Than Intestinal PCSK9 (Proprotein Convertase Subtilisin Kexin Type 9) Regulates Postprandial Lipemia in Mice

Damien Garçon , François Moreau , Audrey Ayer , Wieneke Dijk , Xavier Prieur et al.

Arteriosclerosis, Thrombosis, and Vascular Biology, 2020, 40 (9), pp.2084-2094. ⟨10.1161/ATVBAHA.120.314194⟩

Article dans une revue hal-03012708v1

PiT2/SLC20A2: a new regulator of the bone marrow adipose tissue homeostasis?

Giulia Frangi , Greet Kerckhofs , Jérémy Boulestreau , Florent Autrusseau , Joëlle Veziers et al.

Bone Reports, 2020, 13, pp.100686. ⟨10.1016/j.bonr.2020.100686⟩

Article dans une revue hal-03321800v1
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Human Tolerogenic Dendritic Cells Regulate Immune Responses through Lactate Synthesis

Eros Marín , Laurence Bouchet-Delbos , Ophélie Renoult , Cédric Louvet , Véronique Nerriere-Daguin et al.

Cell Metabolism, 2019, 30 (6), pp.1075-1090. ⟨10.1016/j.cmet.2019.11.011⟩

Article dans une revue inserm-03013619v1
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In vivo evidence for transintestinal cholesterol efflux in patients with complete common bile duct obstruction

François Moreau , Claire Blanchard , Christophe Perret , Laurent Flet , Frédéric Douane et al.

Journal of clinical lipidology, 2019, 13 (1), pp.213-217.e1. ⟨10.1016/j.jacl.2018.09.010⟩

Article dans une revue hal-02429506v1
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Diabetes-related cardiomyopathy: The sweet story of glucose overload from epidemiology to cellular pathways

M. Joubert , A. Manrique , B. Cariou , X. Prieur

Diabetes & Metabolism, 2019, 45, pp.238 - 247. ⟨10.1016/j.diabet.2018.07.003⟩

Article dans une revue hal-03485033v1

Roux-en-Y gastric bypass reduces plasma cholesterol in diet-induced obese mice by affecting trans-intestinal cholesterol excretion and intestinal cholesterol absorption

Claire Blanchard , François Moreau , Audrey Ayer , L. Toque , Damien Garçon et al.

International Journal of Obesity, 2018, Equipe IV, 42 (3), pp.552--560. ⟨10.1038/ijo.2017.232⟩

Article dans une revue hal-01833321v1
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P465L-PPARγ mutation confers partial resistance to the hypolipidemic action of fibrates

Sergio Rodriguez-Cuenca , Stefania Carobbio , Gwendolyn Barceló-Coblijn , Xavier Prieur , Joana Relat et al.

Diabetes, Obesity and Metabolism, 2018, Equipe IV, 1, ⟨10.1111/dom.13370⟩

Article dans une revue hal-01833915v1
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Au cœur de la cardiomyopathie diabétique

Alexandre Lugat , Michael Joubert , Bertrand Cariou , Xavier Prieur

Médecine/Sciences, 2018, 34 (6-7), pp.563-570. ⟨10.1051/medsci/20183406016⟩

Article dans une revue hal-02970120v1

Techniques of Sleeve Gastrectomy and Modified Roux-en-Y Gastric Bypass in Mice

Audrey Ayer , Frederic Borel , Francois Moreau , Xavier Prieur , Michel Neunlist et al.

Journal of visualized experiments : JoVE, 2017, Equipe IV, 121, ⟨10.3791/54905⟩

Article dans une revue hal-01832948v1

One-year metreleptin therapy decreases PCSK9 serum levels in diabetic patients with monogenic lipodystrophy syndromes

C. Vatier , L. Arnaud , X. Prieur , B. Guyomarch , C. Le May et al.

Diabetes & Metabolism, 2017, Equipe IV, 43 (3), pp.275--279. ⟨10.1016/j.diabet.2016.08.004⟩

Article dans une revue istex hal-01833112v1
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Leukocyte RhoA exchange factor Arhgef1 mediates vascular inflammation and atherosclerosis

Maria Luigia Carbone , Gilliane Chadeuf , Sandrine Heurtebise-Chrétien , Xavier Prieur , Thibaut Quillard et al.

Journal of Clinical Investigation, 2017, Equipe III Equipe IV, 127 (12), pp.4516--4526. ⟨10.1172/JCI92702⟩

Article dans une revue hal-01832942v1

The Sodium-Glucose Cotransporter 2 Inhibitor Dapagliflozin Prevents Cardiomyopathy in a Diabetic Lipodystrophic Mouse Model

Michael Joubert , Benoît Jagu , David Montaigne , Xavier Marechal , Angela Tesse et al.

Diabetes, 2017, Equipe IIa Equipe III Equipe IV, 66 (4), pp.1030--1040. ⟨10.2337/db16-0733⟩

Article dans une revue hal-01832151v1
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Seipin deficiency alters brown adipose tissue thermogenesis and insulin sensitivity in a non-cell autonomous mode

Thierry Le Tourneau , J. Magré , M. Joubert , C Le May , Audrey Ayer et al.

Scientific Reports, 2016, 6, pp.35487 - 35487. ⟨10.1038/srep35487⟩

Article dans une revue inserm-01414140v1

Indicators of iron status are correlated with adiponectin expression in adipose tissue of patients with morbid obesity

F. Pihan-Le Bars , Fabrice Bonnet , Olivier Loréal , A. -G. Le Loupp , M. Ropert et al.

Diabetes & Metabolism, 2016, 42 (2), pp.105-111. ⟨10.1016/j.diabet.2015.10.007⟩

Article dans une revue istex hal-01243034v1

FGF21 Improves the Adipocyte Dysfunction Related to Seipin Deficiency

Lucile Dollet , Clara Levrel , Tamer Coskun , Soazig Le Lay , Cedric Le May et al.

Diabetes, 2016, Equipe 5, 65 (11), pp.3410--3417. ⟨10.2337/db16-0327⟩

Article dans une revue hal-01831750v1

PCSK9-deficiency does not alter blood pressure and sodium balance in mouse models of hypertension

Jean-Mathieu Berger , Nathalie Vaillant , Cedric Le May , Carolina Calderon , Jeremy Brégeon et al.

Atherosclerosis, 2015, Equipe 2 Equipe 5, 239 (1), pp.252--259. ⟨10.1016/j.atherosclerosis.2015.01.012⟩

Article dans une revue istex hal-01830594v1

Hematopoietic IKBKE limits the chronicity of inflammasome priming and metaflammation

Meghana Patel , William Bernard , Nikolay Milev , William Cawthorn , Nichola Figg et al.

Proceedings of the National Academy of Sciences of the United States of America, 2014, 112 (2), pp.506-511. ⟨10.1073/pnas.1414536112⟩

Article dans une revue hal-04496743v1

Congenital Lipodystrophies and Dyslipidemias

Xavier Prieur , Cedric Le May , Jocelyne Magré , Bertrand Cariou

Current Atherosclerosis Reports, 2014, 16 (9), pp.437. ⟨10.1007/s11883-014-0437-x⟩

Article dans une revue hal-03013323v1

Transintestinal Cholesterol Excretion Is an Active Metabolic Process Modulated by PCSK9 and Statin Involving ABCB1

Cedric Le May , Jean Mathieu Berger , Anne Lespine , Bruno Pillot , Xavier Prieur et al.

Arteriosclerosis, Thrombosis, and Vascular Biology, 2013, 33 (7), pp.1484-1493. ⟨10.1161/ATVBAHA.112.300263⟩

Article dans une revue hal-03013326v1

Transintestinal Cholesterol Excretion Is an Active Metabolic Process Modulated by PCSK9 and Statin Involving ABCB1

Cedric Le May , Jean Mathieu Berger , Anne Lespine , Bruno Pillot , Xavier Prieur et al.

Arteriosclerosis, Thrombosis, and Vascular Biology, 2013, 33 (7), pp.1484 - 1493. ⟨10.1161/ATVBAHA.112.300263⟩

Article dans une revue hal-02650431v1

Thiazolidinediones partially reverse the metabolic disturbances observed in Bscl2/seipin-deficient mice

X. Prieur , L. Dollet , M. Takahashi , M. Nemani , B. Pillot et al.

Diabetologia, 2013, 56 (8), pp.1813-1825. ⟨10.1007/s00125-013-2926-9⟩

Article dans une revue hal-03013324v1

n-3 PUFA prevent metabolic disturbances associated with obesity and improve endothelial function in golden Syrian hamsters fed with a high-fat diet

Fatima Kasbi Chadli , Agnès André , Xavier Prieur , Gervaise Loirand , Anne Meynier et al.

British Journal of Nutrition, 2012, 107 (9), pp.1305 - 1315. ⟨10.1017/S0007114511004387⟩

Article dans une revue hal-02644896v1

Differential regulation of the human versus the mouse apolipoprotein AV gene by PPARalpha

Xavier Prieur , Philippe Lesnik , Martine Moreau , Joan Rodríguez , Chantal Doucet et al.

Biochimica et Biophysica Acta Molecular and Cell Biology of Lipids, 2009, 1791 (8), pp.764-771. ⟨10.1016/j.bbalip.2009.03.015⟩

Article dans une revue hal-03937548v1
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The lipoprotein lipase inhibitor ANGPTL3 is negatively regulated by thyroid hormone

Charlotte Fugier , Jean-Jacques Tousaint , Xavier Prieur , Michelina Plateroti , Jacques Samarut et al.

Journal of Biological Chemistry, 2006, 281 (17), pp.11553-11559. ⟨10.1074/jbc.M512554200⟩

Article dans une revue hal-02666173v1

Thyroid Hormone Regulates the Hypotriglyceridemic Gene APOA5

Xavier Prieur , Thierry Huby , Hervé Coste , Frank Schaap , M. John Chapman et al.

Journal of Biological Chemistry, 2005, 280 (30), pp.27533-27543. ⟨10.1074/jbc.m503139200⟩

Article dans une revue hal-03937575v1
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Identification of the LIM Protein FHL2 as a Coactivator of β-Catenin

Yu Wei , Claire-Angélique Renard , Charlotte Labalette , Yuanfei Wu , Laurence Lévy et al.

Journal of Biological Chemistry, 2003, 278 (7), pp.5188-5194. ⟨10.1074/jbc.M207216200⟩

Article dans une revue hal-04591138v1

Role of PiT2 in Bone and Adipose Tissues Inter-Communication ?

Giulia Frangi , Greet Kerckhofs , Jérémy Boulestreau , Florent Autrusseau , Joëlle Véziers et al.

4th International Meeting on Bone Marrow Adiposity (BMA2018), Christophe Chauveau; Greet Kerckhofs; Guillaume Penel, Aug 2018, Lille, France

Communication dans un congrès hal-01858343v1

Plasma cholesterol is excreted in the feces of patients with complete common bile duct obstruction : in vivo evidence for tice pathway in humans

François Moreau , Claire Blanchard , Christophe Perret , Laurent Flet , Frédéric Douane et al.

85th Congress of the European-Atherosclerosis-Society (EAS), European Atherosclerosis Society. SWE., Apr 2017, Prague, Czech Republic. pp.2

Communication dans un congrès hal-02737439v1