Xavier Thuru

Identifiants chercheurs

IdHAL :

xavier-thuru

ORCID :

0000-0002-0998-4160

IdRef :

190928859

Présentation

Publications

Article dans une revue (44)

Comparative evaluation of TRIDs : a strategy to improve treatments Fatima Hariss,Sacha Spelier,Louise Damy,Carmen Sandoval Pacheco,Luca Houpeet al. Journal of Translational Medicine, 2026, ⟨10.1186/s12967-026-08058-5⟩ Article dans une revue hal-05605544v1
HR-MS Analysis of the Covalent Binding of Edaravone to 5-Formylpyrimidine Bases and a DNA Oligonucleotide Containing a 5-Formylcytidine Residue. Romain Regnault,Mostafa Kouach,Laurence Goossens,Xavier Thuru,Christian Baillyet al. Rapid Communications in Mass Spectrometry, 2025, Rapid Communications in Mass Spectrometry, 39 (14), pp.e10050. ⟨10.1002/rcm.10050⟩ Article dans une revue hal-05096642v1
Activity of pyridyl-pyrazolone derivatives against Trypanosoma cruzi D. D. G. J. Batista,L. F. de Almeida Fiuza,Frederique Klupsch,K. N. da Costa,M. M. Batistaet al. Experimental Parasitology, 2024, Experimental Parasitology, 262, pp.108787. ⟨10.1016/j.exppara.2024.108787⟩ Article dans une revue hal-04687363v1
Novel PD-L1-Targeted Phenyl-Pyrazolone Derivatives with Antioxidant Properties Romain Regnault,Frédérique Klupsch,Hassiba El-Bouazzati,Romain Magnez,Raphaël Le Biannicet al. Molecules, 2023, 28 (8), pp.3491. ⟨10.3390/molecules28083491⟩ Article dans une revue hal-04139041v1
A Potential Off-Target Effect of the Wnt/β-Catenin Inhibitor KYA1797K: PD-L1 Binding and Checkpoint Inhibition Xavier Thuru,Romain Magnez,Gérard Vergoten,Christian Bailly Biomedicine hub = Biomed Hub, 2023, 8 (1), pp.1-9. ⟨10.1159/000528499⟩ Article dans une revue inserm-03990317v1
Soluble TIM-3 as a biomarker of progression and therapeutic response in cancers and other of human diseases Christian Bailly,Xavier Thuru,Laurence Goossens,Jean-François Goossens Biochemical Pharmacology, 2023, 209, pp.115445. ⟨10.1016/j.bcp.2023.115445⟩ Article dans une revue hal-03990928v1
Microscale Thermophoresis as a Tool to Study Protein Interactions and Their Implication in Human Diseases Romain Magnez,Christian Bailly,Xavier Thuru International Journal of Molecular Sciences, 2022, 23 (14), pp.7672. ⟨10.3390/ijms23147672⟩ Article dans une revue (article de synthèse) hal-03857337v1
Drug Repurposing to Enhance Antitumor Response to PD-1/PD-L1 Immune Checkpoint Inhibitors Xavier Thuru,Romain Magnez,Hassiba El-Bouazzati,Gérard Vergoten,Bruno Quesnelet al. Cancers, 2022, 14 (14), pp.3368. ⟨10.3390/cancers14143368⟩ Article dans une revue (article de synthèse) hal-03857329v1
Pyrazolones as inhibitors of immune checkpoint blocking the PD-1/PD-L1 interaction Raphaël Le Biannic,Romain Magnez,Frédérique Klupsch,Natascha Leleu-Chavain,Bryan Thirouxet al. European Journal of Medicinal Chemistry, 2022, 236, pp.114343. ⟨10.1016/j.ejmech.2022.114343⟩ Article dans une revue hal-03641793v1
IL-2 is inactivated by the acidic pH environment of tumors enabling engineering of a pH-selective mutein Silvia Gaggero,Jonathan Martinez-Fabregas,Adeline Cozzani,Paul Fyfe,Malo Leprohonet al. Science Immunology, 2022, 7 (78), pp.ade5686. ⟨10.1126/sciimmunol.ade5686⟩ Article dans une revue hal-04276595v1
p65/RelA NF‐κB fragments generated by RIPK3 activity regulate tumorigenicity, cell metabolism, and stemness characteristics Yasmine Touil,Céline Latreche‐carton,Hassiba El Bouazzati,Anne‐lucie Nugues,Nathalie Jouyet al. Journal of Cellular Biochemistry, 2022, 123 (3), pp.543-556. ⟨10.1002/jcb.30198⟩ Article dans une revue hal-03641788v1
Functional Analyses of Two Novel LRRK2 Pathogenic Variants in Familial Parkinson's Disease. Ilda Coku,Eugénie Mutez,Sabiha Eddarkaoui,Sébastien Carrier,Antoine Marchandet al. Movement Disorders, 2022, ⟨10.1002/mds.29124⟩ Article dans une revue hal-03703786v1
A Phosphosite Mutant Approach on LRRK2 Links Phosphorylation and Dephosphorylation to Protective and Deleterious Markers, Respectively Antoine Marchand,Alessia Sarchione,Panagiotis Athanasopoulos,Hélène Bauderlique-Le Roy,Liesel Goveaset al. Cells, 2022, 11 (6), pp.1018. ⟨10.3390/cells11061018⟩ Article dans une revue inserm-03625821v1
Antioxidant Properties and Aldehyde Reactivity of PD-L1 Targeted Aryl-Pyrazolone Anticancer Agents Natascha Leleu,Romain Regnault,Hania Ahouari,Raphael Le Biannic,Mostafa Kouachet al. Molecules, 2022, Molecules, 27 (10), pp.3316. ⟨10.3390/molecules27103316⟩ Article dans une revue hal-03714935v1
Mono- and bis-edaravone adducts formed in the presence of vanillin in an aqueous solution Romain Regnault,Mostafa Kouach,Laurence Goossens,Xavier Thuru,Christian Baillyet al. SEPARATION SCIENCE PLUS, 2022, SEPARATION SCIENCE PLUS, ⟨10.1002/sscp.202200031⟩ Article dans une revue hal-04201660v1
The EGF Domains of MUC4 Oncomucin Mediate HER2 Binding Affinity and Promote Pancreatic Cancer Cell Tumorigenesis Nicolas Stoup,Maxime Liberelle,Céline Schulz,Sumeyye Cavdarli,Romain Vasseuret al. Cancers, 2021, 13 (22), pp.5746. ⟨10.3390/cancers13225746⟩ Article dans une revue hal-03641795v1
Tau Stabilizes Chromatin Compaction Thomas Rico,Melissa Gilles,Alban Chauderlier,Thomas Comptdaer,Romain Magnezet al. Frontiers in Cell and Developmental Biology, 2021, 9, pp.740550. ⟨10.3389/fcell.2021.740550⟩ Article dans une revue hal-03429442v1
Discovery of a cryptic site at the interface 2 of TEAD – Towards a new family of YAP/TAZ-TEAD inhibitors Manon Sturbaut,Fabrice Bailly,Mathilde Coevoet,Pasquale Sileo,Martine Pugniereet al. European Journal of Medicinal Chemistry, 2021, 226, pp.113835. ⟨10.1016/j.ejmech.2021.113835⟩ Article dans une revue hal-03429462v1
Soluble Programmed Death Ligand-1 (sPD-L1): A Pool of Circulating Proteins Implicated in Health and Diseases Christian Bailly,Xavier Thuru,Bruno Quesnel Cancers, 2021, 13 (12), pp.3034. ⟨10.3390/cancers13123034⟩ Article dans une revue hal-03278429v1
Properties and reactivity of the folic acid and folate photoproduct 6-formylpterin Jean-François Goossens,Xavier Thuru,Christian Bailly Free Radical Biology and Medicine, 2021, 171, pp.1-10. ⟨10.1016/j.freeradbiomed.2021.05.002⟩ Article dans une revue hal-03226670v1
Modulation of the Gal-9/TIM-3 Immune Checkpoint with α-Lactose. Does Anomery of Lactose Matter? Christian Bailly,Xavier Thuru,Bruno Quesnel Cancers, 2021, 13 (24), pp.6365. ⟨10.3390/cancers13246365⟩ Article dans une revue hal-03641796v1
Chemical reactivity and uses of 1-phenyl-3-methyl-5-pyrazolone (PMP), also known as edaravone Christian Bailly,Paul-Emile Hecquet,Mostafa Kouach,Xavier Thuru,Jean-Francois Goossens Bioorganic and Medicinal Chemistry, 2020, 28 (10), pp.115463. ⟨10.1016/j.bmc.2020.115463⟩ Article dans une revue hal-02873617v1
Combined cytotoxic chemotherapy and immunotherapy of cancer: modern times Christian Bailly,Xavier Thuru,Bruno Quesnel NAR Cancer, 2020, 2 (1), pp.zcaa002. ⟨10.1093/narcan/zcaa002⟩ Article dans une revue (article de synthèse) hal-02873714v1
Enhanced antitumor potential induced by chloroacetate-loaded benzophenones acting as fused tubulin-pyruvate dehydrogenase kinase 1 (PDHK1) ligands Alina Ghinet,Xavier Thuru,Emilie Floquet,Joëlle Dubois,Amaury Farceet al. Bioorganic Chemistry, 2020, 96, pp.103643. ⟨10.1016/j.bioorg.2020.103643⟩ Article dans une revue hal-02873632v1
Measurement of Protein-Protein Interactions through Microscale Thermophoresis (MST) Magnez Romain,Bryan Thiroux,Morgane Tardy,Bruno Quesnel,Xavier Thuru Bio-protocol , 2020, Bio-protocol, 10 (7), ⟨10.21769/bioprotoc.3574⟩ Article dans une revue hal-03185893v1
Aggressiveness potential of spontaneous canine mucosal melanoma can dictate distinct cancer stem cell compartment behaviors in regard to their initial size and expansion abilities Yasmine S. Touil,Zacharie Segaoula,Xavier Thuru,Sylvie Zouitina,Dominique Tiernyet al. Stem Cells and Development, 2020, 29 (14), pp.919-928. ⟨10.1089/scd.2019.0223⟩ Article dans une revue hal-02873700v1
Exploring isoxazoles and pyrrolidinones decorated with the 4,6‐dimethoxy‐1,3,5‐triazine unit as human farnesyltransferase inhibitors Liliana Lucescu,Alina Ghinet,Sergiu Shova,Romain Magnez,Xavier Thuruet al. Archiv der Pharmazie / Chemistry in Life Sciences, 2019, 352 (5), pp.1800227. ⟨10.1002/ardp.201800227⟩ Article dans une revue hal-02873628v1
MUC4-ErbB2 Oncogenic Complex: Binding studies using Microscale Thermophoresis Maxime Liberelle,Romain Magnez,Xavier Thuru,Yamina Bencheikh,Séverine Ravezet al. Scientific Reports, 2019, 9 (1), ⟨10.1038/s41598-019-53099-0⟩ Article dans une revue hal-02407901v1
Isolation and characterization of two canine melanoma cell lines new models for comparative oncology Zacharie Segaoula,Aline Primot,Frederic Lepretre,Benoit Hedan,Emmanuel Bouchaertet al. BMC Cancer, 2018, 18 (1), pp.1219. ⟨10.1186/s12885-018-5114-y⟩ Article dans une revue hal-01972446v1
Toward the Discovery of a Novel Class of YAP–TEAD Interaction Inhibitors by Virtual Screening Approach Targeting YAP–TEAD Protein–Protein Interface Floriane Gibault,Mathilde Coevoet,Manon Sturbaut,Amaury Farce,Nicolas Renaultet al. Cancers, 2018, 10 (5), pp.140. ⟨10.3390/cancers10050140⟩ Article dans une revue hal-02060686v1
PD-1/PD-L1 binding studies using microscale thermophoresis Romain Magnez,Bryan Thiroux,Solenne Taront,Zacharie Segaoula,Bruno Quesnelet al. Scientific Reports, 2017, 7 (1), pp.17623. ⟨10.1038/s41598-017-17963-1⟩ Article dans une revue hal-02873635v1
Synthesis and Biological Evaluation of N -[2-(4-Hydroxyphenylamino)-pyridin-3-yl]-4-methoxy-benzenesulfonamide (ABT-751) Tricyclic Analogues as Antimitotic and Antivascular Agents with Potent in Vivo Antitumor Activity Zacharie Segaoula,Julien Leclercq,Valérie Verones,Nathalie Flouquet,Marie Lecoeuret al. Journal of Medicinal Chemistry, 2016, 59 (18), pp.8422-8440. ⟨10.1021/acs.jmedchem.6b00847⟩ Article dans une revue hal-02060584v1
Phase I Clinical Pharmacology Study of F14512, a New Polyamine-Vectorized Anticancer Drug, in Naturally Occurring Canine Lymphoma D. Tierny,F. Serres,Z. Segaoula,I. Bemelmans,E. Bouchaertet al. Clinical Cancer Research, 2015, 21 (23), pp.5314-5323. ⟨10.1158/1078-0432.ccr-14-3174⟩ Article dans une revue hal-02873640v1
Synthesis and biological evaluation of phenstatin metabolites Alina Ghinet,Benoit Rigo,Jean-Pierre Hénichart,Delphine Le Broc-Ryckewaert,Jean Pommeryet al. Bioorganic and Medicinal Chemistry, 2011, 19 (20), pp.6042-6054. ⟨10.1016/j.bmc.2011.08.047⟩ Article dans une revue istex hal-02873643v1
Colonization of Mice by Candida albicans Is Promoted by Chemically Induced Colitis and Augments Inflammatory Responses through Galectin‐3 Samir Jawhara,Xavier Thuru,Annie Standaert‐vitse,Thierry Jouault,Serge Mordonet al. Journal of Infectious Diseases, 2008, 197 (7), pp.972-980. ⟨10.1086/528990⟩ Article dans une revue hal-02873647v1
C-reactive protein (CRP), a novel adipocytokine overexpressed in mesenteric fat in Crohnʼs disease F Gonzalez,L Peyrin-Biroulet,C Rousseaux,Laurent Dubuquoy,Xavier Thuruet al. Inflammatory Bowel Diseases, 2007, Inflammatory Bowel Diseases, 13 (5), pp.650. ⟨10.1097/00054725-200705005-00026⟩ Article dans une revue hal-03113336v1
P176 C-Reactive Protein (crp), a novel adipocytokine overexpressed in Mesenteric fat in Crohn's disease F. Gonzalez,L. Peyrin-Biroulet,C. Rousseaux,Xavier Thuru,C. Decourcelleet al. Journal of Crohn's and Colitis, 2007, 1 (1), pp.49. ⟨10.1016/s1873-9954(07)70188-x⟩ Article dans une revue hal-02873662v1
Lactobacillus acidophilus modulates intestinal pain and induces opioid and cannabinoid receptors Christel Rousseaux,Xavier Thuru,Agathe Gelot,Nicolas Barnich,Christel Neutet al. Nature Medicine, 2007, 13 (1), pp.35-37. ⟨10.1038/nm1521⟩ Article dans une revue hal-02667010v1
C-reactive protein (CRP), a novel adipocytokine overexpressed in mesenteric fat in Crohnʼs disease F. Gonzalez,L. Peyrin-Biroulet,C. Rousseaux,L. Dubuquoy,Xavier Thuruet al. Inflammatory Bowel Diseases, 2007, 13 (supplement), pp.650. ⟨10.1097/00054725-200705001-00026⟩ Article dans une revue hal-02873652v1
micro-Opioid receptor activation prevents acute hepatic inflammation and cell death. Dania Chakass,David Philippe,Edmone Erdual,Sébastien Dharancy,Mathilde Malapelet al. Gut, 2007, 56 (7), pp.974-81. ⟨10.1136/gut.2006.105122⟩ Article dans une revue hal-00189969v1
Peroxisome Proliferator-Activated Receptor Gamma Functions As An Antibacterial Factor L. Peyrin-Biroulet,Xavier Thuru,C. Vignal,L. Dubuquoy,E. Merouret al. Journal of Crohn's and Colitis, 2007, 1 (1), pp.2. ⟨10.1016/s1873-9954(07)70004-6⟩ Article dans une revue hal-02873659v1
Mu opioid receptor expression is increased in inflammatory bowel diseases: implications for homeostatic intestinal inflammation Xavier Thuru,D Philippe Gut, 2006, 55 (6), pp.815-823. ⟨10.1136/gut.2005.080887⟩ Article dans une revue hal-02873665v1
PPAR as a new therapeutic target in inflammatory bowel diseases Xavier Thuru,L. Dubuquoy Gut, 2006, 55 (9), pp.1341-1349. ⟨10.1136/gut.2006.093484⟩ Article dans une revue hal-02873664v1
Cannabis : des nouvelles fonctions anti-diarrhéiques et anti-cancéreuses Pierre Desreumaux,Xavier Thuru,David Philippe Gastroentérologie Clinique et Biologique / Research and Clinics in Hepatology and Gastroenterology, 2004, 28 (1), pp.97. ⟨10.1016/s0399-8320(04)94859-2⟩ Article dans une revue hal-02873668v1

Poster de conférence (1)

Induction of mu opioid and cannabinoid receptors by probiotics: A new mechanism of regulation of visceral pain perception C. Rousseaux,Xavier Thuru,A. Gelot,N. Barnich,C. Neutet al. 5. Annual Advances in the Inflammatory Bowel Diseases, Dec 2006, Miami (Florida), United States. 13 (Supplement 5), pp.652-653, 2007, Abstracts from the 2006 CCFA National Research and Clinical Conference, 5th Annual Advances in the Inflammatory Bowel Diseases, Dec. 1‐3, 2006, Miami, FL. ⟨10.1097/00054725-200705001-00035⟩ Poster de conférence hal-02873654v1

Brevet (3)

NOVEL PYRAZOLE DERIVATIVES AS PD-1/PD-L1 INTERACTION INHIBITORS Xavier Thuru,Frédérique Klupsch,Christian Bailly,Régis Millet,Raphael Le Biannicet al. France, Patent n° : EP23306103. 2023 Brevet inserm-04542066v1
NOVEL PYRAZOLONE DERIVATIVES AS PD-1/PD-L1 INTERACTION INHIBITORS Xavier Thuru,Bruno Quesnel,Romain Magnez,Régis Millet,Natascha Leleu-Chavainet al. France, Patent n° : WO2021009384. 2021 Brevet inserm-04542080v1
NOVEL PYRAZOLONE DERIVATIVES AS PD-1/PD-L1 INTERACTION INHIBITORS Xavier Thuru,Bruno Quesnel,Magnez Romain,Régis Millet,Natascha Leleu-Chavainet al. France, Patent n° : WO2021009384 (A1). 2021 Brevet hal-03857440v1