Yann Herault Essai 11 Octobre 2021

Présentation

Publications

Article dans une revue (189)

Female C57BL/6J mice perform distinctive urination behaviour accompanied by ultrasonic vocalisation sequences with a stereotyped temporal organisation Fabrice de Chaumont,Gaëlle Yvenou,Ana Perez-Villalba,Yann Hérault,Thomas Bourgeronet al. Behavioural Brain Research, 2025, 495, pp.115788. ⟨10.1016/j.bbr.2025.115788⟩ Article dans une revue hal-05376800v2
A quality framework for cryopreserved rodent disease models: INFRAFRONTIER quality principles in EMMA archiving and distribution Hilke Ehlich,Andrew Blease,Reva Biju,Montse Gustems,Fei Songet al. Mammalian Genome, 2025, 37 (1), pp.10. ⟨10.1007/s00335-025-10174-4⟩ Article dans une revue hal-05457969v1
Ripply3 overdosage induces mid-face shortening through Tbx1 downregulation in Down syndrome models José Tomás Ahumada Saavedra,Claire Chevalier,Agnes Bloch Zupan,Yann Herault PLoS Genetics, 2025, 21 (9), pp.e1011873. ⟨10.1371/journal.pgen.1011873⟩ Article dans une revue hal-05461537v1
Better understanding of laboratory animal genetics will improve reproducibility Guillaume Pavlovic,Sara Wells,Yann Hérault,Lydia Teboul PLoS Biology, 2025, 23 (10), pp.e3003464. ⟨10.1371/journal.pbio.3003464⟩ Article dans une revue hal-05458029v1
Enhancing Visual Discrimination Task: Optimized Mouse Motivation in the Touchscreen Paradigm Jérémy Jehl,Fabrice Riet,Aline Simonet,Yann Herault Current Protocols, 2025, 5 (4), ⟨10.1002/cpz1.70126⟩ Article dans une revue hal-05079124v1
Systematic ocular phenotyping of 8,707 knockout mouse lines identifies genes associated with abnormal corneal phenotypes Peter Vo,Denise Imai-Leonard,Benjamin Yang,Andrew Briere,Andy Shaoet al. BMC Genomics, 2025, 26 (1), pp.48. ⟨10.1186/s12864-025-11222-8⟩ Article dans une revue hal-05227499v1
Interneuron migration defects during corticogenesis contribute to Dyrk1a haploinsufficiency syndrome pathogenesis Maria Victoria Hinckelmann,Aline Dubos,Victorine Artot,Gabrielle Rudolf,Thu Lan Nguyenet al. Molecular Psychiatry, 2025, 30 (11), pp.5227-5244. ⟨10.1038/s41380-025-03109-7⟩ Article dans une revue hal-05393072v2
Dendritic phenotype and proliferation potency in the hippocampal dentate gyrus of the Ts66Yah model of Down syndrome Marco Emili,Fiorenza Stagni,Sandra Guidi,Carla Russo,Claire Chevalieret al. Neuroscience Letters, 2025, 850, pp.138156. ⟨10.1016/j.neulet.2025.138156⟩ Article dans une revue hal-05078930v1
Systematic Ocular Phenotyping of Knockout Mouse Lines Identifies Genes Associated With Age-Related Corneal Dystrophies Andrew Briere,Peter Vo,Benjamin Yang,David Adams,Takanori Amanoet al. Investigative Ophthalmology & Visual Science, 2025, 66 (5), pp.7. ⟨10.1167/iovs.66.5.7⟩ Article dans une revue hal-05227476v1
Ocular Phenotyping of Knockout Mice Identifies Genes Associated With Late Adult Retinal Phenotypes Abraham Hang,Andy Shao,Michael Shea,Michel Roux,Denise Imai-Leonardet al. Investigative Ophthalmology & Visual Science, 2025, 66 (6), pp.64. ⟨10.1167/iovs.66.6.64⟩ Article dans une revue hal-05227463v1
The PTCHD1 protein: A prominent actor in brain function and in neurodevelopmental disorders Dévina C Ung,Stéphane Martin,Yann Hérault,Frédéric Laumonnier Neuroscience and Biobehavioral Reviews, 2025, 176, pp.106307. ⟨10.1016/j.neubiorev.2025.106307⟩ Article dans une revue inserm-05209366v1
Protein arginine methyltransferase 2 controls inflammatory signaling in acute myeloid leukemia Camille Sauter,Thomas Morin,Fabien Guidez,John Simonet,Cyril Fournieret al. Communications Biology, 2024, 7 (1), pp.753. ⟨10.1038/s42003-024-06453-6⟩ Article dans une revue hal-04990682v1
Shaping down syndrome brain cognitive and molecular changes due to aging using adult animals from the Ts66Yah murine model Chiara Lanzillotta,Monika Rataj Baniowska,Francesca Prestia,Chiara Sette,Valérie Nalessoet al. Neurobiology of Disease, 2024, 196, ⟨10.1016/j.nbd.2024.106523⟩ Article dans une revue hal-04673228v1
Rare dentin defects: Understanding the pathophysiological mechanisms of COLXVA1 mutations Isaac Bugueno Valdebenito,Tristan Rey,Alexandra Jimenez-Armijo,Marzena Kawczynski,Naji Kharoufet al. Genes & Diseases, 2024, 11 (5), pp.101303. ⟨10.1016/j.gendis.2024.101303⟩ Article dans une revue hal-04574135v1
Impact of essential genes on the success of genome editing experiments generating 3313 new genetically engineered mouse lines Hillary Elrick,Kevin A Peterson,Brandon J Willis,Denise G Lanza,Elif F Acaret al. Scientific Reports, 2024, 14 (1), pp.22626. ⟨10.1038/s41598-024-72418-8⟩ Article dans une revue hal-04985940v1
The Rogdi knockout mouse is a model for Kohlschütter–Tönz syndrome Alexandra Jimenez-Armijo,Supawich Morkmued,José Tomás Ahumada,Naji Kharouf,Yvan de Feraudyet al. Scientific Reports, 2024, 14 (1), pp.445. ⟨10.1038/s41598-023-50870-2⟩ Article dans une revue hal-04522006v1
Distinct origin and region-dependent contribution of stromal fibroblasts to fibrosis following traumatic injury in mice Daniel Holl,Wing Fung Hau,Anais Julien,Shervin Banitalebi,Jannis Kalkitsaset al. Nature Neuroscience, 2024, 27 (7), pp.1285 - 1298. ⟨10.1038/s41593-024-01678-4⟩ Article dans une revue hal-05019179v1
Organotypic 3D cellular models mimicking the epithelio-ectomesenchymal bi-layer during odontogenesis Fadi Jerbaka,Varvara Gribova,Tristan Rey,Soufian El-Faloussi,Marzena Kawczynskiet al. Tissue Engineering: Parts A, B, and C, 2024, ⟨10.1089/ten.TEA.2024.0118⟩ Article dans une revue hal-04706885v2
Increased dosage of DYRK1A leads to congenital heart defects in a mouse model of Down syndrome Eva Lana-Elola,Rifdat Aoidi,Miriam Llorian,Dorota Gibbins,Callan Buechsenschuetzet al. Science Translational Medicine, 2024, 16 (731), pp.eadd6883. ⟨10.1126/scitranslmed.add6883⟩ Article dans une revue hal-04747430v1
Improving laboratory animal genetic reporting: LAG-R guidelines Lydia Teboul,James Amos-Landgraf,Fernando J Benavides,Marie-Christine Birling,Steve D M Brownet al. Nature Communications, 2024, 15 (5574), ⟨10.1038/s41467-024-49439-y⟩ Article dans une revue hal-04637964v1
Organotypic 3D Cellular Models Mimicking the Epithelio-Ectomesenchymal Bilayer During Odontogenesis Fadi Jerbaka,Varvara Gribova,Tristan Rey,Soufian El-Faloussi,Marzena Kawczynskiet al. Tissue Engineering: Parts A, B, and C, 2024, 31 (11 - 12), pp.471 - 488. ⟨10.1089/ten.tea.2024.0118⟩ Article dans une revue hal-05480636v1
The COL6A5-p.Glu2272* mutation induces chronic itch in mice Ameer Abu Bakr Rasheed,Marie-Christine Birling,Giuseppe Lauria,Claire Gaveriaux-Ruff,Yann Hérault Mammalian Genome, 2024, 35 (2), pp.122-134. ⟨10.1007/s00335-024-10032-9⟩ Article dans une revue hal-04701956v1
How much do we know about the function of mammalian genes? Lydia Teboul,Yann Hérault,Sara Wells,Guillaume Pavlovic BMC Biology, 2023, 21 (1), ⟨10.1186/s12915-023-01794-w⟩ Article dans une revue hal-04701945v1
Day-to-day spontaneous social behaviours is quantitatively and qualitatively affected in a 16p11.2 deletion mouse model Anna Rusu,Claire Chevalier,Fabrice de Chaumont,Valérie Nalesso,Véronique Braultet al. Frontiers in Behavioral Neuroscience, 2023, 17, pp.1294558. ⟨10.3389/fnbeh.2023.1294558⟩ Article dans une revue hal-04673241v1
Genome-wide screening reveals the genetic basis of mammalian embryonic eye development Justine M Chee,Louise Lanoue,Dave Clary,Kendall Higgins,Lynette Boweret al. BMC Biology, 2023, 21 (1), pp.22. ⟨10.1186/s12915-022-01475-0⟩ Article dans une revue hal-04751452v1
Timeline of Developmental Defects Generated upon Genetic Inhibition of the Retinoic Acid Receptor Signaling Pathway Marius Teletin,Manuel Mark,Olivia Wendling,Nadège Vernet,Betty Féretet al. Biomedicines, 2023, 11 (1), ⟨10.3390/biomedicines11010198⟩ Article dans une revue hal-04021094v1
Changes in social behavior with MAPK2 and KCTD13/CUL3 pathways alterations in two new outbred rat models for the 16p11.2 syndromes with autism spectrum disorders Sandra Martin Lorenzo,Maria del Mar Muniz Moreno,Helin Atas,Marion Pellen,Valérie Nalessoet al. Frontiers in Neuroscience, 2023, 17, pp.1148683. ⟨10.3389/fnins.2023.1148683⟩ Article dans une revue inserm-04214586v1
Development of HPV16 mouse and dog models for more accurate prediction of human vaccine efficacy Emmanuelle Totain,Loic Lindner,Nicolas Martin,Yolande Misseri,Alexandra Ichéet al. Laboratory Animal Research, 2023, 39 (1), pp.14. ⟨10.1186/s42826-023-00166-3⟩ Article dans une revue hal-04750862v1
Identifying foetal forebrain interneurons as a target for monogenic autism risk factors and the polygenic 16p11.2 microdeletion Yifei Yang,Sam A Booker,James M Clegg,Idoia Quintana-Urzainqui,Anna Sumeraet al. BMC Neuroscience, 2023, 24 (1), pp.5. ⟨10.1186/s12868-022-00771-3⟩ Article dans une revue hal-04877259v1
Dissecting the autism-associated 16p11.2 locus identifies multiple drivers in neuroanatomical phenotypes and unveils a male-specific role for the major vault protein Perrine Kretz,Christel Wagner,Anna Mikhaleva,Charlotte Montillot,Sylvain Hugelet al. Genome Biology, 2023, 24 (1), pp.261. ⟨10.1186/s13059-023-03092-8⟩ Article dans une revue hal-04651890v1
Stefin B Inhibits NLRP3 Inflammasome Activation via AMPK/mTOR Signalling Mojca Trstenjak-Prebanda,Monika Biasizzo,Klemen Dolinar,Sergej Pirkmajer,Boris Turket al. Cells, 2023, 12 (23), pp.2731. ⟨10.3390/cells12232731⟩ Article dans une revue hal-04747434v1
Increased On-Target Rate and Risk of Concatemerization after CRISPR-Enhanced Targeting in ES Cells Valérie Erbs,Romain Lorentz,Benjamin Eisenman,Laurence Schaeffer,Laurence Luppiet al. Genes, 2023, 14 (2), pp.401. ⟨10.3390/genes14020401⟩ Article dans une revue hal-04758759v1
Gdaphen, R pipeline to identify the most important qualitative and quantitative predictor variables from phenotypic data Maria del Mar Muniz Moreno,Claire Gaveriaux-Ruff,Yann Hérault BMC Bioinformatics, 2023, 24 (1), pp.28. ⟨10.1186/s12859-022-05111-0⟩ Article dans une revue hal-04219165v1
HRAS germline mutations impair LKB1/AMPK signaling and mitochondrial homeostasis in Costello syndrome models Laetitia Dard,Christophe Hubert,Pauline Esteves,Wendy Blanchard,Ghina Bou Aboutet al. JOURNAL OF CLINICAL INVESTIGATION, 2022, 132 (8), ⟨10.1172/JCI131053⟩ Article dans une revue hal-03780356v1
Large-Scale Functional Assessment of Genes Involved in Rare Diseases with Intellectual Disabilities Unravels Unique Developmental and Behaviour Profiles in Mouse Models Hamid Meziane,Marie-Christine Birling,Olivia Wendling,Sophie Leblanc,Aline Duboset al. Biomedicines, 2022, 10 (12), ⟨10.3390/biomedicines10123148⟩ Article dans une revue hal-04219164v1
Structure-Activity Relationship in the Leucettine Family of Kinase Inhibitors Tania Tahtouh,Emilie Durieu,Benoit Villiers,Celine Bruyere,Thu Lan Nguyenet al. Journal of Medicinal Chemistry, 2022, 65 (2), pp.1396-1417. ⟨10.1021/acs.jmedchem.1c01141⟩ Article dans une revue hal-03512536v1
The Human SCN9AR185H Point Mutation Induces Pain Hypersensitivity and Spontaneous Pain in Mice Yaping Xue,Mélanie Kremer,Maria del Mar Muniz Moreno,Celeste Chidiac,Romain Lorentzet al. Frontiers in Molecular Neuroscience, 2022, 15, pp.913990. ⟨10.3389/fnmol.2022.913990⟩ Article dans une revue hal-03844438v1
Analysis of genome-wide knockout mouse database identifies candidate ciliopathy genes Kendall Higgins,Bret A. Moore,Zorana Berberovic,Hibret A. Adissu,Mohammad Eskandarianet al. Scientific Reports, 2022, 12 (1), ⟨10.1038/s41598-022-19710-7⟩ Article dans une revue hal-04217630v1
Behavioral Testing Design for Evaluation of Cognitive Disabilities Fabrice Riet,Christophe Mittelhaeuser,Aline Lux,Raphael Bour,Mohammed Selloumet al. Current Protocols, 2022, 2 (2), ⟨10.1002/cpz1.382⟩ Article dans une revue hal-03861988v1
Chr21 protein-protein interactions: enrichment in proteins involved in intellectual disability, autism, and late-onset Alzheimer's disease Julia Viard,Yann Loe-Mie,Rachel Daudin,Malik Khelfaoui,Christine Planconet al. Life Science Alliance, 2022, 5 (12), ⟨10.26508/lsa.202101205⟩ Article dans une revue hal-04219180v1
INFRAFRONTIER quality principles in systemic phenotyping Hilke Ehlich,Heather Cater,Ann Flenniken,Isabelle Goncalves da Cruz,Anne-Marie Muraet al. Mammalian Genome, 2022, 33 (1), pp.120-122. ⟨10.1007/s00335-021-09892-2⟩ Article dans une revue hal-03433476v1
Overproduction of hydrogen sulfide, generated by cystathionine β-synthase, disrupts brain wave patterns and contributes to neurobehavioral dysfunction in a rat model of down syndrome Theodora Panagaki,Laura Lozano-Montes,Lucia Janickova,Karim Zuhra,Marcell Szaboet al. Redox Biology, 2022, 51, pp.102233. ⟨10.1016/j.redox.2022.102233⟩ Article dans une revue hal-03861983v1
Possible association of 16p11.2 copy number variation with altered lymphocyte and neutrophil counts Giuliana Giannuzzi,Nicolas Chatron,Katrin Mannik,Chiara Auwerx,Sylvain Pradervandet al. npj Genomic Medicine, 2022, 7 (1), pp.38. ⟨10.1038/s41525-022-00308-x⟩ Article dans une revue hal-03862012v1
Ts66Yah, a mouse model of Down syndrome with improved construct and face validity Arnaud Duchon,Maria del Mar Muñiz Moreno,Claire Chevalier,Valérie Nalesso,Philippe Andreet al. Disease Models & Mechanisms, 2022, 15 (12), pp.dmm049721. ⟨10.1242/dmm.049721⟩ Article dans une revue hal-03891136v1
Specific Susceptibility to COVID-19 in Adults with Down Syndrome Tomer Illouz,Arya Biragyn,Milana Frenkel-Morgenstern,Orly Weissberg,Alessandro Gorohovskiet al. NeuroMolecular Medicine, 2021, 23 (4), pp.561-571. ⟨10.1007/s12017-021-08651-5⟩ Article dans une revue hal-03433463v1
Reliable and robust droplet digital PCR (ddPCR) and RT-ddPCR protocols for mouse studies Loic Lindner,Pauline Cayrou,Sylvie Jacquot,Marie-Christine Birling,Yann Heraultet al. Methods, 2021, 191 (4), pp.95-106. ⟨10.1016/j.ymeth.2020.07.004⟩ Article dans une revue hal-03619970v1
Dyrk1a from Gene Function in Development and Physiology to Dosage Correction across Life Span in Down Syndrome Helin Atas-Ozcan,Véronique Brault,Arnaud Duchon,Yann Hérault Genes, 2021, 12 (11), pp.1833. ⟨10.3390/genes12111833⟩ Article dans une revue hal-03540261v1
Pathogenesis of Anorectal Malformations in Retinoic Acid Receptor Knockout Mice Studied by HREM Manuel Mark,Marius Teletin,Olivia Wendling,Jean-Luc Vonesch,Betty Féretet al. Biomedicines, 2021, 9 (7), pp.742. ⟨10.3390/biomedicines9070742⟩ Article dans une revue hal-03357190v1
Multi-influential genetic interactions alter behaviour and cognition through six main biological cascades in Down syndrome mouse models Arnaud Duchon,Maria del Mar Muniz Moreno,Sandra Martin Lorenzo,Marcia Priscilla Silva de Souza,Claire Chevalieret al. Human Molecular Genetics, 2021, 30, pp.771 - 788. ⟨10.1093/hmg/ddab012⟩ Article dans une revue hal-03373458v2
Dyrk1a gene dosage in glutamatergic neurons has key effects in cognitive deficits observed in mouse models of MRD7 and Down syndrome Véronique Brault,Thu Lan Nguyen,Javier Flores-Gutiérrez,Giovanni Iacono,Marie-Christine Birlinget al. PLoS Genetics, 2021, 17 (9), pp.e1009777. ⟨10.1371/journal.pgen.1009777⟩ Article dans une revue hal-03373419v1
Targeting the RHOA pathway improves learning and memory in adult Kctd13 and 16p11.2 deletion mouse models Sandra Martin Lorenzo,Valérie Nalesso,Claire Chevalier,Marie-Christine Birling,Yann Hérault Molecular Autism, 2021, 12 (1), ⟨10.1186/s13229-020-00405-7⟩ Article dans une revue hal-03187247v1
HDAC inhibitor ameliorates behavioral deficits in Mecp2308/y mouse model of Rett syndrome Nicolas Lebrun,Chloé Delépine,Mohamed Selloum,Hamid Meziane,Juliette Nectouxet al. Brain Research, 2021, 1772, pp.147670. ⟨10.1016/j.brainres.2021.147670⟩ Article dans une revue hal-03433491v1
Delta Opioid Receptor in Astrocytes Contributes to Neuropathic Cold Pain and Analgesic Tolerance in Female Mice David Reiss,Hervé Maurin,Emilie Audouard,Miriam Martínez-Navarro,Yaping Xueet al. Frontiers in Cellular Neuroscience, 2021, 15, pp.745178. ⟨10.3389/fncel.2021.745178⟩ Article dans une revue hal-03433496v1
A resource of targeted mutant mouse lines for 5,061 genes Marie-Christine Birling,Atsushi Yoshiki,David Adams,Shinya Ayabe,Arthur Beaudetet al. Nature Genetics, 2021, ⟨10.1038/s41588-021-00825-y⟩ Article dans une revue hal-03065452v1
High Resolution Episcopic Microscopy for Qualitative and Quantitative Data in Phenotyping Altered Embryos and Adult Mice Using the New “Histo3D” System Olivia Wendling,Didier Hentsch,Hugues Jacobs,Nicolas Lemercier,Serge Taubertet al. Biomedicines, 2021, 9 (7), pp.767. ⟨10.3390/biomedicines9070767⟩ Article dans une revue hal-03433478v1
Immune Dysregulation and the Increased Risk of Complications and Mortality Following Respiratory Tract Infections in Adults With Down Syndrome Tomer Illouz,Arya Biragyn,Maria Florencia Iulita,Lisi Flores-Aguilar,Mara Dierssenet al. Frontiers in Immunology, 2021, 12, ⟨10.3389/fimmu.2021.621440⟩ Article dans une revue hal-03285772v1
The effects of Cstb duplication on APP/amyloid-β pathology and cathepsin B activity in a mouse model Yixing Wu,Heather T Whittaker,Suzanna Noy,Karen Cleverley,Veronique Braultet al. PLoS ONE, 2021, 16, ⟨10.1371/journal.pone.0242236⟩ Article dans une revue hal-03373441v1
Droplet digital PCR or quantitative PCR for in-depth genomic and functional validation of genetically altered rodents Loic Lindner,Pauline Cayrou,Thomas W Rosahl,Heather H Zhou,Marie-Christine Birlinget al. Methods, 2021, 191, pp.107 - 119. ⟨10.1016/j.ymeth.2021.04.001⟩ Article dans une revue hal-03306827v1
ProMetIS, deep phenotyping of mouse models by combined proteomics and metabolomics analysis Alyssa Imbert,Magali Rompais,Mohammed Selloum,Florence Castelli,Emmanuelle Mouton-Barbosaet al. Scientific Data , 2021, 8 (1), pp.311. ⟨10.1038/s41597-021-01095-3⟩ Article dans une revue pasteur-03453736v1
Identifying Causative Mechanisms Linking Early-Life Stress to Psycho-Cardio-Metabolic Multi-Morbidity: The EarlyCause Project Nicole Mariani,Alessandra Borsini,Charlotte A.M. Cecil,Janine Felix,Sylvain Sebertet al. PLoS ONE, 2021, 16, pp.e0245475. ⟨10.1371/journal.pone.0245475⟩ Article dans une revue hal-03065469v1
The Human SCN10AG1662S Point Mutation Established in Mice Impacts on Mechanical, Heat, and Cool Sensitivity Céleste Chidiac,Yaping Xue,Maria del Mar Muniz Moreno,Ameer Abu Bakr Rasheed,Romain Lorentzet al. Frontiers in Pharmacology, 2021, 12, pp.780132. ⟨10.3389/fphar.2021.780132⟩ Article dans une revue hal-03706653v1
Building the Future Therapies for Down Syndrome: The Third International Conference of the T21 Research Society Mara Dierssen,Yann Herault,Pablo Helguera,Maria Martínez de Lagran,Anna Vazquezet al. Molecular Syndromology, 2021, 12 (4), pp.202-218. ⟨10.1159/000514437⟩ Article dans une revue hal-03359724v1
Pain behavior in SCN9A (Nav1.7) and SCN10A (Nav1.8) mutant rodent models Yaping Xue,Celeste Chidiac,Yann Herault,Claire Gaveriaux-Ruff Neuroscience Letters, 2021, 753, pp.135844. ⟨10.1016/j.neulet.2021.135844⟩ Article dans une revue hal-03203444v1
Integrative approach to interpret DYRK1A variants, leading to a frequent neurodevelopmental disorder Jérémie Courraud,Eric Chater-Diehl,Benjamin Durand,Marie Vincent,Maria del Mar Muñiz Morenoet al. Genetics in Medicine, 2021, 23 (11), pp.2150-2159. ⟨10.1038/s41436-021-01263-1⟩ Article dans une revue hal-03269307v1
Variability in Genome Editing Outcomes: Challenges for Research Reproducibility and Clinical Safety Lydia Teboul,Yann Herault,Sara Wells,Waseem Qasim,Guillaume Pavlovic Molecular Therapy, 2020, 28 (6), pp.1422-1431. ⟨10.1016/j.ymthe.2020.03.015⟩ Article dans une revue hal-03065520v1
The Deep Genome Project K. C Kent Lloyd,David Adams,Gareth Baynam,Arthur L. Beaudet,Fatima Boschet al. Genome Biology, 2020, 21 (1), ⟨10.1186/s13059-020-1931-9⟩ Article dans une revue hal-03065423v1
High-throughput discovery of genetic determinants of circadian misalignment Tao Zhang,Pancheng Xie,Yingying Dong,Zhiwei Liu,Fei Zhouet al. PLoS Genetics, 2020, 16 (1), pp.e1008577. ⟨10.1371/journal.pgen.1008577⟩ Article dans une revue hal-03065538v1
Soft windowing application to improve analysis of high-throughput phenotyping data Hamed Haselimashhadi,Jeremy Mason,Violeta Munoz-Fuentes,Federico López-Gómez,Kolawole Babalolaet al. Bioinformatics, 2020, 36 (5), pp.1492-1500. ⟨10.1093/bioinformatics/btz744⟩ Article dans une revue hal-03065532v1
BAHD1 haploinsufficiency results in anxiety-like phenotypes in male mice Renaud Pourpre,Laurent Naudon,Hamid Meziane,Goran Lakisic,Luc Jouneauet al. PLoS ONE, 2020, 15 (5), pp.e0232789. ⟨10.1371/journal.pone.0232789⟩ Article dans une revue pasteur-02585985v1
A Small Compound Targeting Prohibitin with Potential Interest for Cognitive Deficit Rescue in Aging mice and Tau Pathology Treatment Anne-Cécile Guyot,Charlotte Leuxe,Clémence Disdier,Nassima Oumata,Narciso Costaet al. Scientific Reports, 2020, 10 (1), pp.1143. ⟨10.1038/s41598-020-57560-3⟩ Article dans une revue hal-02464292v1
Mouse mutant phenotyping at scale reveals novel genes controlling bone mineral density Anna Swan,Christine Schütt,Jan Rozman,Maria del Mar Muñiz Moreno,Stefan Brandmaieret al. PLoS Genetics, 2020, 16 (12), pp.e1009190. ⟨10.1371/journal.pgen.1009190⟩ Article dans une revue hal-03433523v1
Mechanism of cystathionine-β-synthase inhibition by disulfiram: The role of bis(N,N-diethyldithiocarbamate)-copper(II) Karim Zuhra,Theodora Panagaki,Elisa Randi,Fiona Augsburger,Marc Blondelet al. Biochemical Pharmacology, 2020, 182, pp.114267. ⟨10.1016/j.bcp.2020.114267⟩ Article dans une revue hal-03065495v1
Introduction to Mammalian Genome Special Issue: Epigenetics Johannes Beckers,Raffaele Teperino,Yann Hérault,Martin Hrabé de Angelis Mammalian Genome, 2020, 31 (5-6), pp.117-118. ⟨10.1007/s00335-020-09843-3⟩ Article dans une revue hal-03065510v1
Human and mouse essentiality screens as a resource for disease gene discovery Pilar Cacheiro,Violeta Muñoz-Fuentes,Stephen Murray,Mary Dickinson,Maja Bucanet al. Nature Communications, 2020, 11 (1), ⟨10.1038/s41467-020-14284-2⟩ Article dans une revue hal-03065535v1
PATHBIO: an international training program for precision mouse phenotyping Jesus Ruberte,Paul Schofield,Cord Brakebusch,Peter Vogel,Yann Heraultet al. Mammalian Genome, 2020, 31 (1-2), pp.49-53. ⟨10.1007/s00335-020-09829-1⟩ Article dans une revue hal-03065414v1
Erratum: Author Correction: Identification of genes required for eye development by high-throughput screening of mouse knockouts B Moore,B Leonard,L Sebbag,S Edwards,A Cooperet al. Communications Biology, 2019, 2, ⟨10.1038/s42003-019-0349-y⟩ Article dans une revue hal-03676428v1
TUBG1 missense variants underlying cortical malformations disrupt neuronal locomotion and microtubule dynamics but not neurogenesis Ekaterina Ivanova,Johan Gilet,Vadym Sulimenko,Arnaud Duchon,Gabrielle Rudolfet al. Nature Communications, 2019, 10 (1), pp.100-110. ⟨10.1038/s41467-019-10081-8⟩ Article dans une revue hal-02388602v1
HENA, heterogeneous network-based data set for Alzheimer’s disease Elena Sügis,Jerome Dauvillier,Anna Leontjeva,Priit Adler,Valérie Hindieet al. Scientific Data , 2019, 6 (1), pp.151. ⟨10.1038/s41597-019-0152-0⟩ Article dans une revue hal-02388589v1
Genetic quality assurance and genetic monitoring of laboratory mice and rats: FELASA Working Group Report Fernando Benavides,Thomas Rülicke,Jan-Bas Prins,James Bussell,Ferdinando Scavizziet al. Laboratory Animals, 2019, pp.002367721986771. ⟨10.1177/0023677219867719⟩ Article dans une revue hal-02388587v1
Modeling Down syndrome in animals from the early stage to the 4.0 models and next Maria del Mar Muñiz Moreno,Veronique Brault,Yann Hérault,Maria Del Mar,Muñiz Morenoet al. Progress in brain research, 2019, ⟨10.1016/bs.pbr.2019.08.001⟩ Article dans une revue hal-02378243v1
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Specific targeting of the GABA-A receptor α5 subtype by a selective inverse agonist restores cognitive deficits in Down syndrome mice. Jerome Braudeau,B. Delatour,Arnaud Duchon,Philippe Lopes Pereira,Luce Dauphinotet al. Journal of Psychopharmacology, 2011, 25 (8), pp.1030-42. ⟨10.1177/0269881111405366⟩ Article dans une revue hal-00634143v1
Standardized Post‐Mortem Examination and Fixation Procedures for Mutant and Treated Mice Cristina Antal,Stéphanie Muller,Olivia Wendling,Yann Hérault,Manuel Mark Current Protocols in Mouse Biology, 2011, 1 (1), pp.17-53. ⟨10.1002/9780470942390.mo100118⟩ Article dans une revue hal-04611138v1
PCP4 (PEP19) overexpression induces premature neuronal differentiation associated with Ca2+/Calmodulin-Dependent kinase II-δ activation in mouse models of down syndrome François Mouton-Liger,Sophie Thomas,Revital Rattenbach,Laetitia Magnol,Vanessa Larigaldieet al. Journal of Comparative Neurology, 2011, 519 (14), pp.2779--2802. ⟨10.1002/cne.22651⟩ Article dans une revue istex hal-05012202v1
The telomeric part of the human chromosome 21 from Cstb to Prmt2 is not necessary for the locomotor and short-term memory deficits observed in the Tc1 mouse model of Down syndrome Arnaud Duchon,Stéphanie Pothion,Véronique Brault,Andrew J. Sharp,Victor L.J. Tybulewiczet al. Behavioural Brain Research, 2011, 217 (2), pp.271--281. ⟨10.1016/j.bbr.2010.10.023⟩ Article dans une revue hal-05009678v1
Prmt2 Regulates the Lipopolysaccharide-Induced Responses in Lungs and Macrophages Emilie Dalloneau,Patricia Lopes Pereira,Véronique Brault,Elizabeth Nabel,Yann Hérault Journal of Immunology, 2011, 187 (9), pp.4826-4834. ⟨10.4049/jimmunol.1101087⟩ Article dans une revue hal-05004461v1
Chronic Treatment with a Promnesiant GABA-A α5-Selective Inverse Agonist Increases Immediate Early Genes Expression during Memory Processing in Mice and Rectifies Their Expression Levels in a Down Syndrome Mouse Model. Jerome Braudeau,Luce Dauphinot,Arnaud Duchon,Aurore Loistron,Robert H Doddet al. Adv Pharmacol Sci, 2011, 2011, pp.e-153218. ⟨10.1155/2011/153218⟩ Article dans une revue hal-00764914v1
Missense mutation in the second RNA binding domain reveals a role for Prkra (PACT/RAX) during skull development Benjamin K. Dickerman,Christine L. White,Claire Chevalier,Valérie Nalesso,Cyril Charleset al. PLoS ONE, 2011, 6 (12), pp.e28537. ⟨10.1371/journal.pone.0028537⟩ Article dans une revue hal-01129622v1
Characterization of PTZ-Induced Seizure Susceptibility in a Down Syndrome Mouse Model That Overexpresses CSTB Benoit Martin,Nathalie Costet,Jean-Charles Bizot,Yann Hérault,Véronique Brault PLoS ONE, 2011, 6 (11), pp.e27845. ⟨10.1371/journal.pone.0027845⟩ Article dans une revue hal-04984202v1
Down syndrome: from understanding the neurobiology to therapy Katheleen Gardiner,Yann Hérault,Ira T. Lott,Stylianos E. Antonarakis,Roger H. Reeveset al. Journal of Neuroscience, 2010, 30 (45), pp.14943-14945. ⟨10.1523/JNEUROSCI.3728-10.2010⟩ Article dans une revue hal-04031309v1
Controlled somatic and germline copy number variation in the mouse model Yann Hérault,Arnaud Duchon,Damien Maréchal,Matthieu Raveau,Patricia L. Pereiraet al. Current Genomics, 2010, 11 (6), pp.470-480. ⟨10.2174/138920210793176038⟩ Article dans une revue hal-04014327v1
Les modèles animaux en recherche biomédicale M. Malissen,V. Vallet-Erdtmann,Florian Jean Louis Guillou,Y. Hérault,J. Ewbanket al. Biofutur, 2010, 314, pp.34-38 Article dans une revue (article de synthèse) hal-01129411v1
Gene expression signature of cerebellar hypoplasia in a mouse model of Down syndrome during postnatal development. Julien Laffaire,Isabelle Rivals,Luce Dauphinot,Fabien Pasteau,Rosine Wehrleet al. BMC Genomics, 2009, 10 (138), pp.138. ⟨10.1186/1471-2164-10-138⟩ Article dans une revue hal-00804586v1
Heme oxygenase-1 accelerates cutaneous wound healing in mice. Anna Grochot-Przeczek,Radoslaw Lach,Jacek Mis,Klaudia Skrzypek,Malgorzata Gozdeckaet al. PLoS ONE, 2009, 4 (6), pp.e5803. ⟨10.1371/journal.pone.0005803⟩ Article dans une revue hal-00408274v1
Proliferation deficits and gene expression dysregulation in Down's syndrome (Ts1Cje) neural progenitor cells cultured from neurospheres. Randal X Moldrich,Luce Dauphinot,Julien Laffaire,Tania Vitalis,Yann Héraultet al. Journal of Neuroscience Research, 2009, 87 (14), pp.3143-3152 ⟨10.1002/jnr.22131⟩ Article dans une revue istex hal-00408277v1
Fork Stalling and Template Switching (FOSTES) as a Mechanism for Poly-Alanine Tract Expansion Affecting the DYC Mutant of HOXD13, a New Murine Model of Synpolydactyly. Olivier Cocquempot,Veronique Brault,Charles Babinet,Yann Herault Genetics, 2009, 183 (1), epub ahead of print. ⟨10.1534/genetics.109.104695⟩ Article dans une revue hal-00408270v1
Aneuploidy: from a physiological mechanism of variance to down syndrome. Mara Dierssen,Yann Herault,Xavier Estivill Physiological Reviews, 2009, 89 (3), pp.887-920. ⟨10.1152/physrev.00032.2007⟩ Article dans une revue hal-00408268v1
Inducing segmental aneuploid mosaicism in the mouse through targeted asymmetric sister chromatid event of recombination. Arnaud Duchon,Vanessa Besson,Patricia Lopes Pereira,Laetitia Magnol,Yann Hérault Genetics, 2008, 180 (1), pp.51-9. ⟨10.1534/genetics.108.092312⟩ Article dans une revue hal-00408291v1
Inducing segmental aneuploid mosaicism in the mouse through targeted asymmetric sister chromatid event of recombination. A. Duchon,V. Besson,P.L. Pereira,Laetitia Magnol,Y. Herault Genetics, 2008, 180, pp.51-59. ⟨10.1534/j.genetics.108.092312⟩ Article dans une revue hal-01211840v1
Proteomic shifts in embryonic stem cells with gene dose modifications suggest the presence of balancer proteins in protein regulatory networks. Lei Mao,Claus Zabel,Marion Herrmann,Tobias Nolden,Florian Merteset al. PLoS ONE, 2007, 2 (11), pp.e1218. ⟨10.1371/journal.pone.0001218⟩ Article dans une revue hal-00408296v1
Cre/loxP-mediated chromosome engineering of the mouse genome. V. Brault,V. Besson,L. Magnol,A. Duchon,Y. Hérault Handb Exp Pharmacol, 2007, 178, pp.29-48. ⟨10.1007/978-3-540-35109-2_2⟩ Article dans une revue hal-00408334v1
Modeling the monosomy for the telomeric part of human chromosome 21 reveals haploinsufficient genes modulating the inflammatory and airway responses. Vanessa Besson,Véronique Brault,Arnaud Duchon,Dieudonnée Togbe,Jean-Charles Bizotet al. Human Molecular Genetics, 2007, 16 (17), pp.2040-52. ⟨10.1093/hmg/ddm152⟩ Article dans une revue istex hal-00408331v1
KIT is required for hepatic function during mouse post-natal development. Laetitia Magnol,Marie-Clémence Chevallier,Valérie Nalesso,Stéphanie Retif,Helmut Fuchset al. BMC Developmental Biology, 2007, 7 (81), pp.81. ⟨10.1186/1471-213X-7-81⟩ Article dans une revue hal-00408328v1
Modeling chromosomes in mouse to explore the function of genes, genomic disorders and chromosomal organisation V. Brault,P. Pereira,A. Duchon,Y. Hérault PLoS Genetics, 2006, in press, in press Article dans une revue hal-00096002v1
Modeling chromosomes in mouse to explore the function of genes, genomic disorders, and chromosomal organization. Véronique Brault,Patricia Pereira,Arnaud Duchon,Yann Hérault PLoS Genetics, 2006, 2 (7), pp.e86. ⟨10.1371/journal.pgen.0020086⟩ Article dans une revue hal-00408337v1
EMPReSS: standardised phenotype screens for functional annotation of the mouse genome P. Brown,Sdm Chambon,M. Hrabe de Angelis,V. Braulty,Y. Herault Nature Genetics, 2005, 37, pp.1755 Article dans une revue hal-00094570v1
Training and aging modulate the loss-of balance phenotype observed in a new ENU-induced allele of Otopetrin1 V. Besson,V. Nalesso,A. Herpin,Bizot J.-C.,N. Messaddeqet al. Biology of the Cell, 2005, 97, pp.787-98 Article dans une revue hal-00094541v1
Training and aging modulate the loss-of-balance phenotype observed in a new ENU-induced allele of Otopetrin1. Vanessa Besson,Valérie Nalesso,Alexandre Herpin,Jean-Charles Bizot,Nadia Messaddeqet al. Biology of the Cell, 2005, 97 (10), pp.787-98. ⟨10.1042/BC20040525⟩ Article dans une revue hal-00187441v1
Evolutionnary conserved sequences are required for the insulation of the vertebrate HoxD complex in neural cells M. Kmita,B. Tarchini,D. Duboule,Y. Hérault Development (Cambridge, England), 2003, 129, pp.5521-5528 Article dans une revue hal-00095165v1
Serial deletions and duplications suggests a mechanism for the collinearity of Hoxd genes in limbs M. Kmita,N. Fradeau,Y. Hérault,D. Duboule Nature, 2003, 420, pp.145-150 Article dans une revue hal-00095170v1
A nested deletion approach to generate CRE deleter mice with progressive Hox profiles Y. Hérault,M. Kmita,Shawaya Cc,D. Duboule International Journal of Developmental Biology, 2003, 46, pp.186-191 Article dans une revue hal-00095162v1
Genetics of dark skin in mice K.R. Fitch,K.A. Mcgowan,C.D. van Raamsdonk,H. Fuchs,A. Puechet al. Genes and Development, 2003, 17, pp.214-228 Article dans une revue hal-00095121v1
Serum factors and v-src control two complementary mitogenic pathways in quail neuroretinal cells in culture. G. Gillet,D. Michel,P. Crisanti,M. Guerin,Y. Heraultet al. Oncogene, 1993, 8, pp.565-574 Article dans une revue hal-00314337v1

Communication dans un congrès (7)

WD40-repeat 47 is essential for brain development via microtubule-mediated processes and autophagy Binnaz Yalcin,Meghna Kannan,Christel Wagner,Marna Roos,Bruno Rinaldiet al. 51st European Society of Human Genetics (ESHG) Conference, May 2017, Milano, Italy. pp.111 Communication dans un congrès hal-02378786v1
Serotonin 2B receptor potentiates erythropoietin-induced mobilization of endothelial progenitor cells: contribution to hypoxic pulmonary arterial hypertension? Estelle Ayme-Dietrich,Jerome Becker,Ghina Bou About,Luc Maroteaux,Lahcen El Fertaket al. Annual Meeting of French Society of Pharmacology and Therapeutics, and INSERM Clinical Research Centers (CIC), Jun 2018, Toulouse, France Communication dans un congrès hal-03960373v1
Identification d'une nouvelle ADN méthyltransférase « DNMT3C » qui protège les cellules germinales mâles de l'activité des transposons Joan Barau,Aurélie Teissandier,Natasha Zamudio,Stéphanie Roy,Valerie Nalessoet al. 3. Journée de Séminaires du Département Phase sur l'Epigénétique EpiPhase, May 2017, Jouy-en-Josas, France Communication dans un congrès hal-01603099v1
The questions you should ask yourself for efficient CRISPR/Cas9 genome editing Guillaume Pavlovic,Pascale Mercier,Valérie Risson,Philippe Schmitt,Marie-Christine Birlinget al. 13. Transgenic technology meeting, Mar 2016, Prague, Czech Republic Communication dans un congrès hal-02743699v1
Characterization of new genomic regions involved in male reproduction by ENU-mediated chemical mutagenesis strategy Sophie Fouchécourt,E. Desale,V. Nalesso,Betty Fumel,P. Lopes Pereiraet al. 16. European Testis Workshop on Molecular and Cellular Endocrinology, May 2010, Ile d'Elbe, Italy. n.p Communication dans un congrès hal-02815234v1
MEMRI for the morphological and functional study of mouse brain: application to the Down syndrome Patricia Lopes-Pereira,Ahmad Almhdie,Paulo Loureiro de Sousa,Bich-Thuy Doan,Sandra Mêmeet al. 17th Scientific Meeting & Exhibition, Apr 2009, Honolulu, United States Communication dans un congrès hal-00608083v1
Chan-Vese based method to segment mouse brain MRI images: application to cerebral malformation analysis in trisomy 21 Ahmad Almhdie,Patricia Lopes-Pereira,Sandra Même,Caroline Colombier,Veronique Braultet al. Eusipco 2009, Aug 2009, Glasgow, United Kingdom Communication dans un congrès hal-00608092v1

Poster de conférence (2)

ProMetIS 2.0: proteomics and metabolomics data analysis and integration, applied to the characterization of the Lat and Mx2 knock-out phenotypes Oneeb Nasir,Alyssa Imbert,Sylvain Dechaumet,Pierrick Roger,Thomas Burgeret al. Journées Ouvertes en Biologie, Informatique, et Mathématiques (JOBIM 2024), Jun 2024, Toulouse, France. 2007 Poster de conférence hal-05035118v1
Interplay between ultrasonic vocalisation characteristics and behavioural contexts in female mice Elodie Ey,Fabrice de Chaumont,Benoît Forget,Yann Hérault,Thomas Bourgeron NeuroFrance 2023, May 2023, Lyon, France Poster de conférence hal-05217536v1

Chapitre d'ouvrage (2)

CRISMERE Chromosome Engineering in Mouse and Rat Laurence Schaeffer,Loic Lindner,Guillaume Pavlovic,Yann Hérault,Marie-Christine Birling Thomas L. Saunders. Transgenesis. Methods and Protocols, 2631, Springer US, pp.277-297, 2023, Methods in Molecular Biology, 978-1-0716-2990-1. ⟨10.1007/978-1-0716-2990-1_12⟩ Chapitre d'ouvrage hal-04069097v1
The in vivo Down syndrome genomic library in mouse Yann Hérault,Véronique Brault,Arnaud Duchon,Emilie Velot,Damien Marechal Progress in Brain Research, 197, Elsevier, pp.169--197, 2012, 978-0-444-54299-1. ⟨10.1016/B978-0-444-54299-1.00009-1⟩ Chapitre d'ouvrage hal-05004439v1

Autre publication scientifique (1)

DYRK1A up-regulation specifically impairs a presynaptic form of long-term potentiation Aude-Marie Lepagnol-Bestel,Simon Haziza,Julia Viard,Paul A. Salin,Valérie Crépelet al. 2019, ⟨10.1101/645200⟩ Autre publication scientifique hal-03060184v1

Pré-publication, Document de travail (6)

Female C57BL/6J mice perform distinctive urination behaviour accompanied by ultrasonic vocalisations sequences with a stereotypic temporal organisation Fabrice de Chaumont,Gaëlle Yvenou,Ana Perez Villalba,Yann Hérault,Thomas Bourgeronet al. 2025 Pré-publication, Document de travail hal-05217541v1
Towards Preclinical Validation of Arbaclofen (R-baclofen) Treatment for 16p11.2 Deletion Syndrome Brigitta B Gundersen,William T O’brien,Melanie D Schaffler,Maria N Schultz,Tatsuya Tsukaharaet al. 2023 Pré-publication, Document de travail hal-04959070v1
A 16p11.2 deletion mouse model displays quantitatively and qualitatively different behaviours in sociability and social novelty over short- and long-term observation Anna Rusu,Claire Chevalier,Fabrice de Chaumont,Valérie Nalesso,Véronique Braultet al. 2022 Pré-publication, Document de travail hal-03803875v1
BIN1 genetic risk factor for Alzheimer is sufficient to induce early structural tract alterations in entorhinal cortex-dentate gyrus pathway and related hippocampal multi-scale impairments R Daudin,D Marechal,Q Wang,Y Abe,N Bourget al. 2020 Pré-publication, Document de travail hal-03065480v1
Chr21 protein-protein interactions: enrichment in products involved in intellectual disabilities, autism and Late Onset Alzheimer Disease Julia Viard,Yann Loe-Mie,Rachel Daudin,Malik Khelfaoui,Christine Planconet al. 2020 Pré-publication, Document de travail hal-03065473v1
Pioglitazone improves deficits of Fmr1-KO mouse model of Fragile X syndrome by interfering with excessive diacylglycerol signaling Andréa Geoffroy,Karima Habbas,Boglarka Zambo,Laetitia Schramm,Arnaud Duchonet al. 2020 Pré-publication, Document de travail hal-03028259v1

Rapport (2)

EOSC-Life -D1.3 EOSC-Life EOSC FAIR services deployment for open calls Helen Parkinson,Philip Gribbon,Ugis Sarkans,Gesa Witt,Andrea Zalianiet al. D1.3, Fraunhofer-Institut für Offene Kommunikationssysteme (FOKUS Fraunhofer); EMBL; CSIC; VU; BBMRI; KNAW; UVEG; USMI; IMG; UNIMAN; LUMC; EATRIS; UNIMIB; EBI; ECRIN; EMBRC; EMPHASIS (FZJ); ERINHA; INFRAFRONTIER; INRAE; UNIVDUN; HMGU; CERBM; BSCRC; UOULU; CRRMMP. 2022 Rapport hal-04161824v1
EOSC-Life D1.2 EOSC repository deployment for project demonstrators Helen Parkinson,Philip Gribbon,Ugis Sarkans,Gesa Witt,Andrea Zalianiet al. 1.2, Fraunhofer-Institut für Offene Kommunikationssysteme (FOKUS Fraunhofer); EMBL; LUMC; EATRIS; INRAE; ECRIN; EMBRC; EMPHASIS (FZJ); ERINHA; INFRAFRONTIER; UNIMIB; UNIVDUN; VU; HMGU; CERBM; BSCRC; UOULU; CIRMMP; CSIC; KNAW; BBMRI; UVEG; USMI; IMG; CNRI; UNIMAN. 2021 Rapport hal-04162006v1