Yvain Nicolet

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Publications

Dynamics driving the precursor in NifEN scaffold during nitrogenase FeMo-cofactor assembly

Lucía Payá Tormo , Tu-Quynh Nguyen , Cameron Fyfe , Hind Basbous , Katarzyna Dobrzyńska et al.

Nature Chemical Biology, 2025, ⟨10.1038/s41589-025-02070-4⟩

Article dans une revue hal-05366614v1
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A scaffold for quinone channeling between membrane and soluble bacterial oxidoreductases

M. Broc , M. Cherrier , A. Uzel , R. Arias-Cartin , P. Arnoux et al.

Nature Structural and Molecular Biology, 2025, 32, pp.2196-2202. ⟨10.1038/s41594-025-01607-4⟩

Article dans une revue hal-05229188v1
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Peptide recognition and mechanism of the radical S -Adenosyl- l -methionine multiple cyclophane synthase ChlB

Jérémie Ruel , Thi Quynh Ngoc Nguyen , Yohei Morishita , Anthony Usclat , Lydie Martin et al.

Journal of the American Chemical Society, 2025, 147 (20), pp.16850-16863. ⟨10.1021/jacs.4c16004⟩

Article dans une revue hal-05065181v1

Radical S -Adenosyl- l -Methionine Enzyme PylB: A C-Centered Radical to Convert l -Lysine into (3 R )-3-Methyl- d -Ornithine

Feryel Soualmia , Mickael Cherrier , Timothée Chauviré , Mickaël Mauger , Philip Tatham et al.

Journal of the American Chemical Society, 2024, 146 (10), pp.6493-6505. ⟨10.1021/jacs.3c03747⟩

Article dans une revue hal-04496232v1

Iron–sulfur clusters as inhibitors and catalysts of viral replication

Kourosh Honarmand Ebrahimi , Simone Ciofi-Baffoni , Peter-Leon Hagedoorn , Yvain Nicolet , Nick Le Brun et al.

Nature Chemistry, 2022, ⟨10.1038/s41557-021-00882-0⟩

Article dans une revue hal-03590147v1
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Oxygen-sensitive metalloprotein structure determination by cryo-electron microscopy

Mickaël Cherrier , Xavier Vernède , Daphna Fenel , Lydie Martin , Benoit Arragain et al.

Biomolecules, 2022, 12 (3), pp.441. ⟨10.3390/biom12030441⟩

Article dans une revue hal-03615151v1

Characterization of a Radical SAM Oxygenase for the Ether Crosslinking in Darobactin Biosynthesis

Hai Nguyen , I Dewa Made Kresna , Nils Böhringer , Jeremie Ruel , Eugenio de La Mora et al.

Journal of the American Chemical Society, 2022, ⟨10.1021/jacs.2c05565⟩

Article dans une revue hal-03807959v1

Structure and Catalytic Mechanism of Radical SAM Methylases

Tu-Quynh Nguyen , Yvain Nicolet

Life, 2022, 12 (11), pp.1732. ⟨10.3390/life12111732⟩

Article dans une revue hal-03853118v1

L-tyrosine-bound ThiH structure reveals C–C bond break differences within radical SAM aromatic amino acid lyases

Patricia Amara , Claire Saragaglia , Jean-Marie Mouesca , Lydie Martin , Yvain Nicolet

Nature Communications, 2022, 13 (1), pp.2284. ⟨10.1038/s41467-022-29980-4⟩

Article dans une revue hal-03669800v1
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Radical SAM Enzymes and Metallocofactor Assembly: A Structural Point of View

Yvain Nicolet , Mickael Cherrier , Patricia Amara

ACS Bio & Med Chem Au, 2021, 2 (1), pp.36-52. ⟨10.1021/acsbiomedchemau.1c00044⟩

Article dans une revue hal-03454299v1

New developments in RiPP discovery, enzymology and engineering

Manuel Montalbán-López , Thomas Scott , Sangeetha Ramesh , Imran Rahman , Auke van Heel et al.

Natural Product Reports, 2021, ⟨10.1039/d0np00027b⟩

Article dans une revue hal-02947402v1

Crystal structure of the [FeFe]-Hydrogenase maturase HydE bound to complex-B

Roman Rohac , Lydie Martin , Liang Liu , Debashis Basu , Lizhi Tao et al.

Journal of the American Chemical Society, 2021, 143 (22), pp.8499-8508. ⟨10.1021/jacs.1c03367⟩

Article dans une revue hal-03328547v1

Methods to Screen for Radical SAM Enzyme Crystallization Conditions

Lydie Martin , Xavier Vernède , Yvain Nicolet

Methods in Molecular Biology, 2021, 2353, pp.333-348. ⟨10.1007/978-1-0716-1605-5_17⟩

Article dans une revue hal-03328451v1

An Unexpected P-Cluster like Intermediate En Route to the Nitrogenase FeMo-co

Leon Jenner , Mickaël Cherrier , Patricia Amara , Luis Rubio , Yvain Nicolet

Chemical Science, 2021, ⟨10.1039/D1SC00289A⟩

Article dans une revue hal-03161940v1

Structural insights into the mechanism of the radical SAM carbide synthase NifB, a key nitrogenase cofactor maturating enzyme

Ana Sosa Fajardo , Pierre Legrand , Lucía Payá-Tormo , Lydie Martin , Maria Teresa Pellicer Martinez et al.

Journal of the American Chemical Society, 2020, ⟨10.1021/jacs.0c02243⟩

Article dans une revue hal-02775951v1

High-resolution structure of a modular hyperthermostable endo-β-1,4-mannanase from Thermotoga petrophila: The ancillary immunoglobulin-like module is a thermostabilizing domain

Viviam da Silva , Aline Cabral , Marcia Sperança , Fabio Squina , João Renato C Muniz et al.

Biochimica et Biophysica Acta Proteins and Proteomics, 2020, 1868 (8), pp.140437. ⟨10.1016/j.bbapap.2020.140437⟩

Article dans une revue hal-02556971v1
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A way to thioacetate esters compatible with non-oxidative prebiotic conditions

Naoual Leqraa , Yvain Nicolet , Anne Milet , Yannick Vallée

Scientific Reports, 2020, 10 (1), pp.14488. ⟨10.1038/s41598-020-71524-7⟩

Article dans une revue hal-02934448v1

Structure–function relationships of radical SAM enzymes

Yvain Nicolet

Nature Catalysis, 2020, 3, pp.337-350. ⟨10.1038/s41929-020-0448-7⟩

Article dans une revue hal-02547495v1

How [Fe]-hydrogenase metabolizes dihydrogen

Yvain Nicolet

Nature Catalysis, 2019, 2 (6), pp.481-482. ⟨10.1038/s41929-019-0296-5⟩

Article dans une revue hal-02166639v1

1,2-diol dehydration by the radical SAM enzyme AprD4 – a matter of proton circulation and substrate flexibility

Qi Liu , Patricia Amara , Jean-Marie Mouesca , Xinjian Ji , Oriane Renoux et al.

Journal of the American Chemical Society, 2018, ⟨10.1021/jacs.7b10501⟩

Article dans une revue hal-01685058v1

Radical S -Adenosyl- l -methionine Tryptophan Lyase (NosL): How the Protein Controls the Carboxyl Radical •CO 2 – Migration

Patricia Amara , Jean-Marie Mouesca , Maxime Bella , Lydie Martin , Claire Saragaglia et al.

Journal of the American Chemical Society, 2018, 140 (48), pp.16661-16668. ⟨10.1021/jacs.8b09142⟩

Article dans une revue hal-02008403v1

Human viperin catalyzes the modification of GPP and FPP potentially affecting cholesterol synthesis

Pavel Mikulecky , Elena Andreeva , Patricia Amara , Winfried Weissenhorn , Yvain Nicolet et al.

FEBS Letters, 2018, ⟨10.1002/1873-3468.12941⟩

Article dans une revue hal-01677120v1

Fine-tuning of a radical-based reaction by radical S-adenosyl-L-methionine tryptophan lyase

G. Sicoli , J.-M. Mouesca , Laura Zeppieri , Patricia Amara , Lydie Martin et al.

Science, 2016, 351 (6279), pp.1320-1323. ⟨10.1126/science.aad8995⟩

Article dans une revue hal-01297885v1

CO and CN- syntheses by [FeFe]-hydrogenase maturase HydG are catalytically differentiated events.

Adrien Pagnier , Lydie Martin , Laura Zeppieri , Yvain Nicolet , Juan-Carlos Fontecilla-Camps

Proceedings of the National Academy of Sciences of the United States of America, 2016, 113 (1), pp.104-9

Article dans une revue hal-01252697v1

Carbon-sulfur bond-forming reaction catalysed by the radical SAM enzyme HydE.

Roman Rohac , Patricia Amara , Alhosna Benjdia , Lydie Martin , Pauline Ruffié et al.

Nature Chemistry, 2016, 8 (5), pp.491-500. ⟨10.1038/NCHEM.2490⟩

Article dans une revue hal-01341083v1

Crystal structure of HydG from Carboxydothermus hydrogenoformans: a trifunctional [FeFe]-hydrogenase maturase.

Yvain Nicolet , Adrien Pagnier , Laura Zeppieri , Lydie Martin , Patricia Amara et al.

ChemBioChem, 2015, 16 (3), pp.397-402

Article dans une revue hal-01166126v1

Tryptophan Lyase (NosL): Mechanistic Insights from Substrate Analogues and Mutagenesis.

Dhananjay M Bhandari , Hui Xu , Yvain Nicolet , Juan-Carlos Fontecilla-Camps , Tadhg P Begley

Biochemistry, 2015, 54 (31), pp.4767-9

Article dans une revue hal-01191593v1

IscS from Archaeoglobus fulgidus has no desulfurase activity but may provide a cysteine ligand for [Fe2S2] cluster assembly.

Adrien Pagnier , Yvain Nicolet , Juan-Carlos Fontecilla-Camps

BBA - Biochimica et Biophysica Acta, 2015, 1853 (6), pp.1457-1463

Article dans une revue hal-01119798v1

The crystal structure of the global anaerobic transcriptional regulator FNR explains its extremely fine-tuned monomer-dimer equilibrium

Anne Volbeda , Claudine Darnault , O. Renoux , Yvain Nicolet , Juan-Carlos Fontecilla-Camps

Science Advances , 2015, 1 (11), pp.e1501086. ⟨10.1126/sciadv.1501086⟩

Article dans une revue hal-01240354v1

Crystal structure of tryptophan lyase (NosL): evidence for radical formation at the amino group of tryptophan.

Yvain Nicolet , Laura Zeppieri , Patricia Amara , Juan-Carlos Fontecilla-Camps

Angewandte Chemie International Edition, 2014, 53 (44), pp.11840-4

Article dans une revue hal-01119795v1

Crystal structures of human cholinesterases in complex with huprine W and tacrine: elements of specificity for anti-Alzheimer's drugs targeting acetyl- and butyryl-cholinesterase.

Florian Nachon , Eugénie Carletti , Cyril Ronco , Marie Trovaslet , Yvain Nicolet et al.

Biochemical Journal, 2013, 453 (3), pp.393-399. ⟨10.1042/BJ20130013⟩

Article dans une revue hal-00996550v1

Crystal structure and functional studies of an unusual l -cysteine desulfurase from Archaeoglobus fulgidus

Yasuaki Yamanaka , Laura Zeppieri , Yvain Nicolet , Elodie N Marinoni , Jaim S de Oliveira et al.

Dalton Transactions, 2013, 42 (9), pp.3092 - 3099. ⟨10.1039/c2dt32101g⟩

Article dans une revue hal-01666076v1

X-ray snapshots of possible intermediates in the time course of synthesis and degradation of protein-bound Fe4S4 clusters

Yvain Nicolet , Roman Rohac , Lydie Martin , Juan-Carlos Fontecilla-Camps

Proceedings of the National Academy of Sciences of the United States of America, 2013, 110 (18), pp.7188 - 7192. ⟨10.1073/pnas.1302388110⟩

Article dans une revue hal-01664850v1

Further Characterization of the [FeFe]-Hydrogenase Maturase HydG

Cécile Tron , Mickael V Cherrier , Patricia Amara , Lydie Martin , Martin Fauth et al.

European Journal of Inorganic Chemistry, 2011, 2011 (7 SI), pp.1121-1127. ⟨10.1002/ejic.201001101⟩

Article dans une revue istex hal-01140285v1

Reactibodies generated by kinetic selection couple chemical reactivity with faborable protein dynamics

Ivan Smirnov , Eugénie Carletti , Inna Kurkova , Florian Nachon , Yvain Nicolet et al.

Proceedings of the National Academy of Sciences of the United States of America, 2011, 108 (38), pp.15954-15959. ⟨10.1073/pnas.1108460108⟩

Article dans une revue hal-00637416v1
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X-ray crystallographic snapshots of reaction intermediates in the G117H mutant of human butyrylcholinesterase, a nerve agent target engineered into a catalytic bioscavenger

Florian Nachon , Eugenie Carletti , Marielle Wandhammer , Yvain Nicolet , Lawrence M Schopfer et al.

Biochemical Journal, 2011, 434 (1), pp.73-82. ⟨10.1042/BJ20101648⟩

Article dans une revue hal-00560692v1

Maturation of [FeFe]-hydrogenases: Structures and mechanisms

Yvain Nicolet , Juan-Carlos Fontecilla-Camps , Marc Fontecave

International Journal of Hydrogen Energy, 2010, 35 (19), pp.10750-10760. ⟨10.1016/j.ijhydene.2010.02.056⟩

Article dans une revue istex hal-01145486v1

A glycyl free radical as the precursor in the synthesis of carbon monoxide and cyanide by the [FeFe]-hydrogenase maturase HydG

Yvain Nicolet , Lydie Martin , Cécile Tron , Juan-Carlos Fontecilla-Camps

FEBS Letters, 2010, 584 (19), pp.4197-4202. ⟨10.1016/j.febslet.2010.09.008⟩

Article dans une revue istex hal-01235598v1

The role of the maturase HydG in [FeFe]-hydrogenase active site synthesis and assembly

Eric Pilet , Yvain Nicolet , Carole Mathevon , Thierry Douki , Juan-Carlos Fontecilla-Camps et al.

FEBS Letters, 2009, 583 (3), pp.506-511

Article dans une revue hal-00371635v1
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Structure-activity analysis of aging and reactivation of human butyrylcholinesterase inhibited by analogues of tabun

Eugénie Carletti , Nadine Aurbek , Emilie Gillon , Mélanie Loiodice , Yvain Nicolet et al.

Biochemical Journal, 2009, 421 (1), pp.97-106. ⟨10.1042/BJ20090091⟩

Article dans une revue hal-00479152v1
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Structure-function relationships of anaerobic gas-processing metalloenzymes

Juan-Carlos Fontecilla-Camps , Patricia Amara , Christine Cavazza , Yvain Nicolet , Anne Volbeda

Nature, 2009, 460 (7257), pp.814-822. ⟨10.1038/nature08299⟩

Article dans une revue istex cea-00909652v1

X-ray structure of the [Fe-Fe]-hydrogenase maturase hydE from thermotoga maritima.

Yvain Nicolet , Jon K. Ruback , Matthew C. Posewitz , Patricia Amara , Carole Mathevon et al.

Journal of Biological Chemistry, 2008, 283 (27), pp.18861-18872

Article dans une revue hal-00377680v1

Characterization of the DNA repair spore photoproduct lyase enzyme from Clostridium acetobutylicum: A radical-SAM enzyme.

Alexia Chandor , Thierry Douki , Didier Gasparutto , Serge Gambarelli , Yiannis Sanakis et al.

Comptes Rendus. Chimie, 2007, 10, pp.756-765

Article dans une revue hal-00377642v2
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Structural Changes of Escherichia coli Ferric Uptake Regulator during Metal-dependent Dimerization and Activation Explored by NMR and X-ray Crystallography

Ludovic Pecqueur , Benoit d'Autreaux , Jérôme Dupuy , Yvain Nicolet , Lilian Jacquamet et al.

Journal of Biological Chemistry, 2006, 281 (30), pp.21286-21295. ⟨10.1074/jbc.M601278200⟩

Article dans une revue hal-02975695v1

Journey to Understanding the Biotin Synthase Mechanism

Nikolas Alansson , Sandrine Ollagnier de Choudens , Yvain Nicolet

2025 FrenchBIC Annual Meeting, May 2025, Amboise, France

Poster de conférence hal-05483952v1
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The hexameric atypical thioredoxin from poplar, DCC1, possesses a redox holdase activity

Natacha Donnay , Tiphaine Dhalleine , Flavien Zannini , Mickael Cherrier , Yvain Nicolet et al.

Thiol oxidation in biology: Biochemical mechanisms to physiological outcomes, Sep 2025, Sant Feliu De Guixols, Spain

Poster de conférence hal-05306663v1