Yvain Nicolet

Publications

Article dans une revue (44)

A scaffold for quinone channeling between membrane and soluble bacterial oxidoreductases M. Broc,M. Cherrier,A. Uzel,R. Arias-Cartin,P. Arnouxet al. Nature Structural and Molecular Biology, 2025, 32, pp.2196-2202. ⟨10.1038/s41594-025-01607-4⟩ Article dans une revue hal-05229188v1
Peptide recognition and mechanism of the radical S -Adenosyl- l -methionine multiple cyclophane synthase ChlB Jérémie Ruel,Thi Quynh Ngoc Nguyen,Yohei Morishita,Anthony Usclat,Lydie Martinet al. Journal of the American Chemical Society, 2025, 147 (20), pp.16850-16863. ⟨10.1021/jacs.4c16004⟩ Article dans une revue hal-05065181v1
Dynamics driving the precursor in NifEN scaffold during nitrogenase FeMo-cofactor assembly Lucía Payá Tormo,Tu-Quynh Nguyen,Cameron Fyfe,Hind Basbous,Katarzyna Dobrzyńskaet al. Nature Chemical Biology, 2025, ⟨10.1038/s41589-025-02070-4⟩ Article dans une revue hal-05366614v1
Radical S -Adenosyl- l -Methionine Enzyme PylB: A C-Centered Radical to Convert l -Lysine into (3 R )-3-Methyl- d -Ornithine Feryel Soualmia,Mickael Cherrier,Timothée Chauviré,Mickaël Mauger,Philip Tathamet al. Journal of the American Chemical Society, 2024, 146 (10), pp.6493-6505. ⟨10.1021/jacs.3c03747⟩ Article dans une revue hal-04496232v1
Iron–sulfur clusters as inhibitors and catalysts of viral replication Kourosh Honarmand Ebrahimi,Simone Ciofi-Baffoni,Peter-Leon Hagedoorn,Yvain Nicolet,Nick Le Brunet al. Nature Chemistry, 2022, ⟨10.1038/s41557-021-00882-0⟩ Article dans une revue hal-03590147v1
Oxygen-sensitive metalloprotein structure determination by cryo-electron microscopy Mickaël Cherrier,Xavier Vernède,Daphna Fenel,Lydie Martin,Benoit Arragainet al. Biomolecules, 2022, 12 (3), pp.441. ⟨10.3390/biom12030441⟩ Article dans une revue hal-03615151v1
Characterization of a Radical SAM Oxygenase for the Ether Crosslinking in Darobactin Biosynthesis Hai Nguyen,I Dewa Made Kresna,Nils Böhringer,Jeremie Ruel,Eugenio de La Moraet al. Journal of the American Chemical Society, 2022, ⟨10.1021/jacs.2c05565⟩ Article dans une revue hal-03807959v1
Structure and Catalytic Mechanism of Radical SAM Methylases Tu-Quynh Nguyen,Yvain Nicolet Life, 2022, 12 (11), pp.1732. ⟨10.3390/life12111732⟩ Article dans une revue hal-03853118v1
L-tyrosine-bound ThiH structure reveals C–C bond break differences within radical SAM aromatic amino acid lyases Patricia Amara,Claire Saragaglia,Jean-Marie Mouesca,Lydie Martin,Yvain Nicolet Nature Communications, 2022, 13 (1), pp.2284. ⟨10.1038/s41467-022-29980-4⟩ Article dans une revue hal-03669800v1
Radical SAM Enzymes and Metallocofactor Assembly: A Structural Point of View Yvain Nicolet,Mickael Cherrier,Patricia Amara ACS Bio & Med Chem Au, 2021, 2 (1), pp.36-52. ⟨10.1021/acsbiomedchemau.1c00044⟩ Article dans une revue hal-03454299v1
New developments in RiPP discovery, enzymology and engineering Manuel Montalbán-López,Thomas Scott,Sangeetha Ramesh,Imran Rahman,Auke van Heelet al. Natural Product Reports, 2021, ⟨10.1039/d0np00027b⟩ Article dans une revue hal-02947402v1
Crystal structure of the [FeFe]-Hydrogenase maturase HydE bound to complex-B Roman Rohac,Lydie Martin,Liang Liu,Debashis Basu,Lizhi Taoet al. Journal of the American Chemical Society, 2021, 143 (22), pp.8499-8508. ⟨10.1021/jacs.1c03367⟩ Article dans une revue hal-03328547v1
Methods to Screen for Radical SAM Enzyme Crystallization Conditions Lydie Martin,Xavier Vernède,Yvain Nicolet Methods in Molecular Biology, 2021, 2353, pp.333-348. ⟨10.1007/978-1-0716-1605-5_17⟩ Article dans une revue hal-03328451v1
An Unexpected P-Cluster like Intermediate En Route to the Nitrogenase FeMo-co Leon Jenner,Mickaël Cherrier,Patricia Amara,Luis Rubio,Yvain Nicolet Chemical Science, 2021, ⟨10.1039/D1SC00289A⟩ Article dans une revue hal-03161940v1
High-resolution structure of a modular hyperthermostable endo-β-1,4-mannanase from Thermotoga petrophila: The ancillary immunoglobulin-like module is a thermostabilizing domain Viviam da Silva,Aline Cabral,Marcia Sperança,Fabio Squina,João Renato C Munizet al. Biochimica et Biophysica Acta Proteins and Proteomics, 2020, 1868 (8), pp.140437. ⟨10.1016/j.bbapap.2020.140437⟩ Article dans une revue hal-02556971v1
A way to thioacetate esters compatible with non-oxidative prebiotic conditions Naoual Leqraa,Yvain Nicolet,Anne Milet,Yannick Vallée Scientific Reports, 2020, 10 (1), pp.14488. ⟨10.1038/s41598-020-71524-7⟩ Article dans une revue hal-02934448v1
Structure–function relationships of radical SAM enzymes Yvain Nicolet Nature Catalysis, 2020, 3, pp.337-350. ⟨10.1038/s41929-020-0448-7⟩ Article dans une revue hal-02547495v1
Structural insights into the mechanism of the radical SAM carbide synthase NifB, a key nitrogenase cofactor maturating enzyme Ana Sosa Fajardo,Pierre Legrand,Lucía Payá-Tormo,Lydie Martin,Maria Teresa Pellicer Martinezet al. Journal of the American Chemical Society, 2020, ⟨10.1021/jacs.0c02243⟩ Article dans une revue hal-02775951v1
How [Fe]-hydrogenase metabolizes dihydrogen Yvain Nicolet Nature Catalysis, 2019, 2 (6), pp.481-482. ⟨10.1038/s41929-019-0296-5⟩ Article dans une revue hal-02166639v1
1,2-diol dehydration by the radical SAM enzyme AprD4 – a matter of proton circulation and substrate flexibility Qi Liu,Patricia Amara,Jean-Marie Mouesca,Xinjian Ji,Oriane Renouxet al. Journal of the American Chemical Society, 2018, ⟨10.1021/jacs.7b10501⟩ Article dans une revue hal-01685058v1
Radical S -Adenosyl- l -methionine Tryptophan Lyase (NosL): How the Protein Controls the Carboxyl Radical •CO 2 – Migration Patricia Amara,Jean-Marie Mouesca,Maxime Bella,Lydie Martin,Claire Saragagliaet al. Journal of the American Chemical Society, 2018, 140 (48), pp.16661-16668. ⟨10.1021/jacs.8b09142⟩ Article dans une revue hal-02008403v1
Human viperin catalyzes the modification of GPP and FPP potentially affecting cholesterol synthesis Pavel Mikulecky,Elena Andreeva,Patricia Amara,Winfried Weissenhorn,Yvain Nicoletet al. FEBS Letters, 2018, ⟨10.1002/1873-3468.12941⟩ Article dans une revue hal-01677120v1
Fine-tuning of a radical-based reaction by radical S-adenosyl-L-methionine tryptophan lyase G. Sicoli,J.-M. Mouesca,Laura Zeppieri,Patricia Amara,Lydie Martinet al. Science, 2016, 351 (6279), pp.1320-1323. ⟨10.1126/science.aad8995⟩ Article dans une revue hal-01297885v1
CO and CN- syntheses by [FeFe]-hydrogenase maturase HydG are catalytically differentiated events. Adrien Pagnier,Lydie Martin,Laura Zeppieri,Yvain Nicolet,Juan-Carlos Fontecilla-Camps Proceedings of the National Academy of Sciences of the United States of America, 2016, 113 (1), pp.104-9 Article dans une revue hal-01252697v1
Carbon-sulfur bond-forming reaction catalysed by the radical SAM enzyme HydE. Roman Rohac,Patricia Amara,Alhosna Benjdia,Lydie Martin,Pauline Ruffiéet al. Nature Chemistry, 2016, 8 (5), pp.491-500. ⟨10.1038/NCHEM.2490⟩ Article dans une revue hal-01341083v1
Tryptophan Lyase (NosL): Mechanistic Insights from Substrate Analogues and Mutagenesis. Dhananjay M Bhandari,Hui Xu,Yvain Nicolet,Juan-Carlos Fontecilla-Camps,Tadhg P Begley Biochemistry, 2015, 54 (31), pp.4767-9 Article dans une revue hal-01191593v1
IscS from Archaeoglobus fulgidus has no desulfurase activity but may provide a cysteine ligand for [Fe2S2] cluster assembly. Adrien Pagnier,Yvain Nicolet,Juan-Carlos Fontecilla-Camps BBA - Biochimica et Biophysica Acta, 2015, 1853 (6), pp.1457-1463 Article dans une revue hal-01119798v1
The crystal structure of the global anaerobic transcriptional regulator FNR explains its extremely fine-tuned monomer-dimer equilibrium Anne Volbeda,Claudine Darnault,O. Renoux,Yvain Nicolet,Juan-Carlos Fontecilla-Camps Science Advances , 2015, 1 (11), pp.e1501086. ⟨10.1126/sciadv.1501086⟩ Article dans une revue hal-01240354v1
Crystal structure of HydG from Carboxydothermus hydrogenoformans: a trifunctional [FeFe]-hydrogenase maturase. Yvain Nicolet,Adrien Pagnier,Laura Zeppieri,Lydie Martin,Patricia Amaraet al. ChemBioChem, 2015, 16 (3), pp.397-402 Article dans une revue hal-01166126v1
Crystal structure of tryptophan lyase (NosL): evidence for radical formation at the amino group of tryptophan. Yvain Nicolet,Laura Zeppieri,Patricia Amara,Juan-Carlos Fontecilla-Camps Angewandte Chemie International Edition, 2014, 53 (44), pp.11840-4 Article dans une revue hal-01119795v1
Crystal structures of human cholinesterases in complex with huprine W and tacrine: elements of specificity for anti-Alzheimer's drugs targeting acetyl- and butyryl-cholinesterase. Florian Nachon,Eugénie Carletti,Cyril Ronco,Marie Trovaslet,Yvain Nicoletet al. Biochemical Journal, 2013, 453 (3), pp.393-399. ⟨10.1042/BJ20130013⟩ Article dans une revue hal-00996550v1
Crystal structure and functional studies of an unusual l -cysteine desulfurase from Archaeoglobus fulgidus Yasuaki Yamanaka,Laura Zeppieri,Yvain Nicolet,Elodie N Marinoni,Jaim S de Oliveiraet al. Dalton Transactions, 2013, 42 (9), pp.3092 - 3099. ⟨10.1039/c2dt32101g⟩ Article dans une revue hal-01666076v1
X-ray snapshots of possible intermediates in the time course of synthesis and degradation of protein-bound Fe4S4 clusters Yvain Nicolet,Roman Rohac,Lydie Martin,Juan-Carlos Fontecilla-Camps Proceedings of the National Academy of Sciences of the United States of America, 2013, 110 (18), pp.7188 - 7192. ⟨10.1073/pnas.1302388110⟩ Article dans une revue hal-01664850v1
X-ray crystallographic snapshots of reaction intermediates in the G117H mutant of human butyrylcholinesterase, a nerve agent target engineered into a catalytic bioscavenger Florian Nachon,Eugenie Carletti,Marielle Wandhammer,Yvain Nicolet,Lawrence M Schopferet al. Biochemical Journal, 2011, 434 (1), pp.73-82. ⟨10.1042/BJ20101648⟩ Article dans une revue hal-00560692v1
Reactibodies generated by kinetic selection couple chemical reactivity with faborable protein dynamics Ivan Smirnov,Eugénie Carletti,Inna Kurkova,Florian Nachon,Yvain Nicoletet al. Proceedings of the National Academy of Sciences of the United States of America, 2011, 108 (38), pp.15954-15959. ⟨10.1073/pnas.1108460108⟩ Article dans une revue hal-00637416v1
Further Characterization of the [FeFe]-Hydrogenase Maturase HydG Cécile Tron,Mickael V Cherrier,Patricia Amara,Lydie Martin,Martin Fauthet al. European Journal of Inorganic Chemistry, 2011, 2011 (7 SI), pp.1121-1127. ⟨10.1002/ejic.201001101⟩ Article dans une revue istex hal-01140285v1
A glycyl free radical as the precursor in the synthesis of carbon monoxide and cyanide by the [FeFe]-hydrogenase maturase HydG Yvain Nicolet,Lydie Martin,Cécile Tron,Juan-Carlos Fontecilla-Camps FEBS Letters, 2010, 584 (19), pp.4197-4202. ⟨10.1016/j.febslet.2010.09.008⟩ Article dans une revue istex hal-01235598v1
Maturation of [FeFe]-hydrogenases: Structures and mechanisms Yvain Nicolet,Juan-Carlos Fontecilla-Camps,Marc Fontecave International Journal of Hydrogen Energy, 2010, 35 (19), pp.10750-10760. ⟨10.1016/j.ijhydene.2010.02.056⟩ Article dans une revue istex hal-01145486v1
Structure-activity analysis of aging and reactivation of human butyrylcholinesterase inhibited by analogues of tabun Eugénie Carletti,Nadine Aurbek,Emilie Gillon,Mélanie Loiodice,Yvain Nicoletet al. Biochemical Journal, 2009, 421 (1), pp.97-106. ⟨10.1042/BJ20090091⟩ Article dans une revue hal-00479152v1
Structure-function relationships of anaerobic gas-processing metalloenzymes Juan-Carlos Fontecilla-Camps,Patricia Amara,Christine Cavazza,Yvain Nicolet,Anne Volbeda Nature, 2009, 460 (7257), pp.814-822. ⟨10.1038/nature08299⟩ Article dans une revue istex cea-00909652v1
The role of the maturase HydG in [FeFe]-hydrogenase active site synthesis and assembly Eric Pilet,Yvain Nicolet,Carole Mathevon,Thierry Douki,Juan-Carlos Fontecilla-Campset al. FEBS Letters, 2009, 583 (3), pp.506-511 Article dans une revue hal-00371635v1
X-ray structure of the [Fe-Fe]-hydrogenase maturase hydE from thermotoga maritima. Yvain Nicolet,Jon K. Ruback,Matthew C. Posewitz,Patricia Amara,Carole Mathevonet al. Journal of Biological Chemistry, 2008, 283 (27), pp.18861-18872 Article dans une revue hal-00377680v1
Characterization of the DNA repair spore photoproduct lyase enzyme from Clostridium acetobutylicum: A radical-SAM enzyme. Alexia Chandor,Thierry Douki,Didier Gasparutto,Serge Gambarelli,Yiannis Sanakiset al. Comptes Rendus. Chimie, 2007, 10, pp.756-765 Article dans une revue hal-00377642v2
Structural Changes of Escherichia coli Ferric Uptake Regulator during Metal-dependent Dimerization and Activation Explored by NMR and X-ray Crystallography Ludovic Pecqueur,Benoit d'Autreaux,Jérôme Dupuy,Yvain Nicolet,Lilian Jacquametet al. Journal of Biological Chemistry, 2006, 281 (30), pp.21286-21295. ⟨10.1074/jbc.M601278200⟩ Article dans une revue hal-02975695v1

Poster de conférence (2)

Journey to Understanding the Biotin Synthase Mechanism Nikolas Alansson,Sandrine Ollagnier de Choudens,Yvain Nicolet 2025 FrenchBIC Annual Meeting, May 2025, Amboise, France Poster de conférence hal-05483952v1
The hexameric atypical thioredoxin from poplar, DCC1, possesses a redox holdase activity Natacha Donnay,Tiphaine Dhalleine,Flavien Zannini,Mickael Cherrier,Yvain Nicoletet al. Thiol oxidation in biology: Biochemical mechanisms to physiological outcomes, Sep 2025, Sant Feliu De Guixols, Spain Poster de conférence hal-05306663v1

Chapitre d'ouvrage (4)

Radical S-Adenosyl-l-Methionine Carbon Monoxide and Cyanide Synthase HydG Yvain Nicolet,Juan-Carlos Fontecilla-Camps Encyclopedia of Inorganic and Bioinorganic Chemistry, 2017, ⟨10.1002/9781119951438.eibc2506⟩ Chapitre d'ouvrage hal-01644311v1
Fumarate and Nitrate Reduction Regulator (FNR) Anne Volbeda,Yvain Nicolet,Juan-Carlos Fontecilla-Camps Encyclopedia of Inorganic and Bioinorganic Chemistry, 2017, ⟨10.1002/9781119951438.eibc2504⟩ Chapitre d'ouvrage hal-01592572v1
Iron-sulfur clusters and molecular oxygen: function, adaptation, degradation, and repair Yvain Nicolet,Juan-Carlos Fontecilla-Camps Rouault Tracey. Iron-Sulfur Clusters in Chemistry and Biology, De GRUYTER, pp.239-266, 2014, ⟨10.1515/9783110308426.239⟩ Chapitre d'ouvrage hal-01326167v1
Fe–S Clusters: Biogenesis and Redox, Catalytic, and Regulatory Properties Yvain Nicolet,Juan-Carlos Fontecilla-Camps Bioinspired Catalysis, Wolfgang Weigand and Philippe Schollhammer, pp.21-48, 2014, 9783527333080. ⟨10.1002/9783527664160.ch2⟩ Chapitre d'ouvrage hal-01326158v1