yves collette

Identifiants chercheurs

IdHAL :

yves-collette

ORCID :

0000-0001-5359-7099

IdRef :

070509891

ResearcherID :

F-2270-2013

Présentation

CRCM (INSERM, AMU, Institut Paoli calmettes, CNRS)

Publications

Article dans une revue (61)

Dual targeting of CDK6 and LSD1 is synergistic and overcomes differentiation blockade in AML Lise Brault,Edwige Voisset,Mathieu Desaunay,Antonia Boudet,Paraskevi Kousteridouet al. EMBO Molecular Medicine, 2025, 17 (10), pp.2632 - 2660. ⟨10.1038/s44321-025-00296-2⟩ Article dans une revue hal-05344739v1
Dasatinib overcomes AML cells resistant to BCL2 inhibition by degrading MCL1 Sylvain Garciaz,Camille Montersino,Maxence Bourgoin,Arnaud Jacquel,Rémy Castellanoet al. British Journal of Haematology, 2025, 207 (2), pp.381-386. ⟨10.1111/bjh.20195⟩ Article dans une revue hal-05575967v1
Dual targeting of CDK6 and LSD1 is synergistic and overcomes differentiation blockade in AML Lise Brault,Edwige Voisset,Mathieu Desaunay,Antonia Boudet,Paraskevi Kousteridouet al. EMBO Molecular Medicine, 2025, ⟨10.1038/s44321-025-00296-2⟩ Article dans une revue hal-05267162v1
ETx-22, a Novel Nectin-4–Directed Antibody–Drug Conjugate, Demonstrates Safety and Potent Antitumor Activity in Low-Nectin-4–Expressing Tumors Marc Lopez,Emerence Crompot,Emmanuelle Josselin,Anne Farina,Marion Rubiset al. Cancer Research Communications, 2024, 4 (11), pp.2998-3012. ⟨10.1158/2767-9764.CRC-24-0176⟩ Article dans une revue hal-04887527v1
Venetoclax Resistance in Acute Myeloid Leukemia Sylvain Garciaz,Marie-Anne Hospital,Yves Collette,Norbert Vey Cancers, 2024, 16 (6), pp.1091. ⟨10.3390/cancers16061091⟩ Article dans une revue hal-04945122v1
INA03: A Potent Transferrin-Competitive Antibody–Drug Conjugate against CD71 for Safer Acute Leukemia Treatment Manuela Bratti,Elisa Stubbs,Sergii Kolodych,Herve Souchet,Lois Kellyet al. Molecular Cancer Therapeutics, 2024, 23 (8), pp.1159-1175. ⟨10.1158/1535-7163.MCT-23-0548⟩ Article dans une revue hal-04887535v1
From a drug repositioning to a structure-based drug design approach to tackle acute lymphoblastic leukemia Magali Saez-Ayala,Laurent Hoffer,Sébastien Abel,Khaoula Ben Yaala,Benoit Sicardet al. Nature Communications, 2023, 14 (1), pp.3079. ⟨10.1038/s41467-023-38668-2⟩ Article dans une revue hal-04237671v1
C/EBPα Confers Dependence to Fatty Acid Anabolic Pathways and Vulnerability to Lipid Oxidative Stress–Induced Ferroptosis in FLT3 -Mutant Leukemia Marie Sabatier,Rudy Birsen,Laura Lauture,Sarah Mouche,Paolo Angelinoet al. Cancer Discovery, 2023, 13 (7), pp.1720-1747. ⟨10.1158/2159-8290.CD-22-0411⟩ Article dans une revue hal-04166110v1
Niche-expressed Galectin-1 is involved in pre-B acute lymphoblastic leukemia relapse through pre-B cell receptor activation Jeoffrey Pelletier,Marielle Balzano,Jérôme Destin,Camille Montersino,Marjorie Delahayeet al. iScience, 2023, 26 (4), pp.106385. ⟨10.1016/j.isci.2023.106385⟩ Article dans une revue hal-04077435v1
Downregulation of stromal syntenin sustains AML development Raphael Leblanc,Rania Ghossoub,Armelle Goubard,Rémy Castellano,Joanna Fareset al. EMBO Molecular Medicine, 2023, 15 (11), ⟨10.15252/emmm.202317570⟩ Article dans une revue hal-04532862v1
CD36 Drives Metastasis and Relapse in Acute Myeloid Leukemia Thomas Farge,Jean Nakhle,Damien Lagarde,Guillaume Cognet,Nathaniel Polleyet al. Cancer Research, 2023, 83 (17), pp.2824-2838. ⟨10.1158/0008-5472.CAN-22-3682⟩ Article dans une revue hal-04282332v1
CRCM5484: A BET- BDII Selective Compound With Differential Anti-Leukemic Drug Modulation Kendall Carrasco,Camille Montersino,Carine Derviaux,Magali Saez-Ayala,Laurent Hofferet al. Journal of Medicinal Chemistry, 2022, pp.acs.jmedchem.1c02168. ⟨10.1021/acs.jmedchem.1c02168⟩ Article dans une revue hal-03624836v1
Antimicrobial and cytotoxic effects of marine sponge extracts &lt;i&gt;Agelas clathrodes&lt;/i&gt;, &lt;i&gt;Desmapsamma anchorata&lt;/i&gt; and &lt;i&gt;Verongula rigida&lt;/i&gt; from a Caribbean Island Julie Piron,Stéphane Betzi,Jessica Pastour,Audrey Restouin,Remy Castellanoet al. PeerJ, 2022, 10, pp.e13955. ⟨10.7717/peerj.13955⟩ Article dans une revue hal-03803766v1
RAS activation induces synthetic lethality of MEK inhibition with mitochondrial oxidative metabolism in acute myeloid leukemia Justine Decroocq,Rudy Birsen,Camille Montersino,Prasad Chaskar,Jordi Manoet al. Leukemia, 2022, 36 (5), pp.1237-1252. ⟨10.1038/s41375-022-01541-0⟩ Article dans une revue hal-04085323v1
CD47-SIRPα Controls ADCC Killing of Primary T Cells by PMN Through a Combination of Trogocytosis and NADPH Oxidase Activation Françoise Gondois-Rey,Thomas Miller,Vladimir Laletin,Xavier Morelli,Yves Colletteet al. Frontiers in Immunology, 2022, 13, pp.899068. ⟨10.3389/fimmu.2022.899068⟩ Article dans une revue hal-03857250v1
H3.3K27M Mutation Controls Cell Growth and Resistance to Therapies in Pediatric Glioma Cell Lines Andria Rakotomalala,Quentin Bailleul,Clara Savary,Mélanie Arcicasa,Maud Hamadouet al. Cancers, 2021, 13 (21), pp.5551. ⟨10.3390/cancers13215551⟩ Article dans une revue hal-03418323v1
Development of ICT01, a first-in-class, anti-BTN3A antibody for activating Vγ9Vδ2 T cell–mediated antitumor immune response Aude de Gassart,Kieu-Suong Le,Patrick Brune,Sophie Agaugué,Jennifer Simset al. Science Translational Medicine, 2021, 13 (616), ⟨10.1126/scitranslmed.abj0835⟩ Article dans une revue inserm-03540734v1
The NANOTUMOR consortium - Towards the Tumor Cell Atlas Florent Colin,Kristine Schauer,Ali Hamiche,Pierre Martineau,Jean-Paul Borget al. Biology of the Cell, 2021, 113 (6), pp.272-280. ⟨10.1111/boc.202000135⟩ Article dans une revue hal-03169719v1
Synergy and allostery in ligand binding by HIV-1 Nef Abdullah Aldehaiman,Afaque A Momin,Audrey Restouin,Luyao Wang,Xiaoli Shiet al. Biochemical Journal, 2021, 478 (8), pp.1525 - 1545. ⟨10.1042/bcj20201002⟩ Article dans une revue hal-03380308v1
Mitochondrial metabolism supports resistance to IDH mutant inhibitors in acute myeloid leukemia Lucille Stuani,Marie Sabatier,Estelle Saland,Guillaume Cognet,Nathalie Poupinet al. Journal of Experimental Medicine, 2021, 218 (5), pp.e20200924. ⟨10.1084/jem.20200924⟩ Article dans une revue hal-03563454v1
ICOS is widely expressed in cutaneous T-cell lymphoma, and its targeting promotes potent killing of malignant cells Florent Amatore,Nicolas Ortonne,Marc Lopez,Florence Orlanducci,Rémy Castellanoet al. Blood Advances, 2020, 4 (20), pp.5203-5214. ⟨10.1182/bloodadvances.2020002395⟩ Article dans une revue hal-03152734v1
A chemogenomic approach to identify personalized therapy for patients with relapse or refractory acute myeloid leukemia: results of a prospective feasibility study A. Collignon,M. A Hospital,C. Montersino,F. Courtier,A. Charbonnieret al. Blood Cancer Journal, 2020, 10 (6), pp.64. ⟨10.1038/s41408-020-0330-5⟩ Article dans une revue inserm-03038330v1
ICOS is widely expressed in cutaneous T-cell lymphoma, and its targeting promotes potent killing of malignant cells Florent Amatore,Nicolas Ortonne,Marc Lopez,Florence Orlanducci,Rémy Castellanoet al. Blood Advances, 2020, 4 (20), pp.5203-5214. ⟨10.1182/bloodadvances.2020002395⟩ Article dans une revue inserm-03038313v1
A gain-of-function RAC2 mutation is associated with bone-marrow hypoplasia and an autosomal dominant form of severe combined immunodeficiency Chantal Lagresle-Peyrou,Aurélien Olichon,Hanem Sadek,Philippe Roche,Claudine Tardyet al. Haematologica, In press, 106 (2), pp.404-411. ⟨10.3324/haematol.2019.230250⟩ Article dans une revue hal-02545998v1
In silico molecular target prediction unveils mebendazole as a potent MAPK14 inhibitor Jeremy Ariey‐bonnet,Kendall Carrasco,Marion Le Grand,Laurent Hoffer,Stéphane Betziet al. Molecular Oncology, 2020, 14, pp.3083 - 3099. ⟨10.1002/1878-0261.12810⟩ Article dans une revue hal-02989358v1
Correction: CD95L Cell Surface Cleavage Triggers a Prometastatic Signaling Pathway in Triple-Negative Breast Cancer Marine Malleter,Sébastien Tauzin,Alban Bessede,Rémy Castellano,Armelle Goubardet al. Cancer Research, 2020, 80 (3), pp.639-639. ⟨10.1158/0008-5472.CAN-19-3636⟩ Article dans une revue hal-05165942v1
Correction to A Novel Covalent mTOR Inhibitor, DHM25, Shows in Vivo Antitumor Activity against Triple-Negative Breast Cancer Cells Amélie Fouqué,Olivier Delalande,Mickael Jean,Rémy Castellano,Emmanuelle Josselinet al. Journal of Medicinal Chemistry, 2019, 62 (20), pp.9339-9340. ⟨10.1021/acs.jmedchem.9b01578⟩ Article dans une revue hal-02526957v1
A genome-wide RNAi screen reveals essential therapeutic targets of breast cancer stem cells Abir Arfaoui,Claire Rioualen,Violette Azzoni,Guillaume Pinna,Pascal Finettiet al. EMBO Molecular Medicine, 2019, 11 (10), pp.e9930. ⟨10.15252/emmm.201809930⟩ Article dans une revue hal-02539524v1
Immunomodulatory Drugs Exert Anti-Leukemia Effects in Acute Myeloid Leukemia by Direct and Immunostimulatory Activities Aude Le Roy,Thomas Prebet,Remy Castellano,Armelle Goubard,Florence Riccardiet al. Frontiers in Immunology, 2018, 9, pp.977. ⟨10.3389/fimmu.2018.00977⟩ Article dans une revue hal-01791593v1
Integrated Strategy for Lead Optimization Based on Fragment Growing: The Diversity-Oriented-Target-Focused-Synthesis Approach Laurent Hoffer,Yuliia Voitovich,Brigitt Raux,Kendall Carrasco,Christophe Mulleret al. Journal of Medicinal Chemistry, 2018, 61 (13), pp.5719-5732. ⟨10.1021/acs.jmedchem.8b00653⟩ Article dans une revue hal-02067797v1
Cegal Protocol : Evaluation of the Feasibility of a Chemogenomic Approach to Identify Personalized Therapy for Relapse or Refractory AML Patients Norbert Vey,Marie Anne Hospital,Aude Collignon,Yves Collette,Daniel Birnbaumet al. Blood, 2018, 132 (1), ⟨10.1182/blood-2018-99-119263⟩ Article dans une revue hal-02143630v1
Chemotherapy-Resistant Human Acute Myeloid Leukemia Cells Are Not Enriched for Leukemic Stem Cells but Require Oxidative Metabolism Thomas Farge,Estelle Saland,Fabienne de Toni,Nesrine Aroua,Mohsen Hosseiniet al. Cancer Discovery, 2017, 7 (7), pp.716-735. ⟨10.1158/2159-8290.cd-16-0441⟩ Article dans une revue inserm-02465205v1
Nectin-4: a new prognostic biomarker for efficient therapeutic targeting of primary and metastatic triple-negative breast cancer M. M-Rabet,O. Cabaud,E. Josselin,P. Finetti,R. Castellanoet al. Annals of Oncology, 2017, ⟨10.1093/annonc/mdw678⟩ Article dans une revue hal-01787533v1
JAM-C Identifies Src Family Kinase-Activated Leukemia-Initiating Cells and Predicts Poor Prognosis in Acute Myeloid Leukemia Maria de Grandis,Florence Bardin,Cyril Fauriat,Christophe Zemmour,Abdessamad El-Kaoutariet al. Cancer Research, 2017, 77 (23), pp.6627-6640. ⟨10.1158/0008-5472.CAN-17-1223⟩ Article dans une revue hal-01789603v1
Identification of p62/SQSTM1 as a component of non-canonical Wnt VANGL2–JNK signalling in breast cancer Tania M. Puvirajesinghe,François Bertucci,Ashish Jain,Pierluigi Scerbo,Edwige Belottiet al. Nature Communications, 2016, 7, pp.10318. ⟨10.1038/ncomms10318⟩ Article dans une revue hal-01447570v1
Exploring Selective Inhibition of the First Bromodomain of the Human Bromodomain and Extra-terminal Domain (BET) Proteins Brigitt Raux,Yuliia Voitovich,Carine Derviaux,Adrien Lugari,Etienne Rebuffetet al. Journal of Medicinal Chemistry, 2016, 59 (4, SI), pp.1634-1641. ⟨10.1021/acs.jmedchem.5b01708⟩ Article dans une revue hal-01439086v1
BTN3A molecules considerably improve Vγ9Vδ2T cells-based immunotherapy in acute myeloid leukemia Audrey Benyamine,Aude Le Roy,Emilie Mamessier,Julie Gertner-Dardenne,Céline Castanieret al. OncoImmunology, 2016, 5 (10), pp.e1146843. ⟨10.1080/2162402X.2016.1146843⟩ Article dans une revue hal-03606408v1
Protein-Protein Interaction Inhibition (2P21)-Oriented Chemical Library Accelerates Hit Discovery Sabine Milhas,Brigitt Raux,Stéphane Betzi,Carine Derviaux,Philippe Rocheet al. ACS Chemical Biology, 2016, 11 (8), pp.2140-2148. ⟨10.1021/acschembio.6b00286⟩ Article dans une revue hal-01439116v1
Drug response profiling can predict response to ponatinib in a patient with t(1;9)(q24;q34)-associated B-cell acute lymphoblastic leukemia Y Collette,Thomas Prébet,A. Goubard,José Adelaïde,R Castellanoet al. Blood Cancer Journal, 2015, 5 (e292), ⟨10.1038/bcj.2015.13⟩ Article dans une revue hal-01218497v1
A Novel Covalent mTOR Inhibitor, DHM25, Shows in Vivo Antitumor Activity against Triple-Negative Breast Cancer Cells Amelie Fouque,Olivier Delalande,Mickael Jean,Remy Castellano,Emmanuelle Josselinet al. Journal of Medicinal Chemistry, 2015, 58 (16), pp.6559-6573. ⟨10.1021/acs.jmedchem.5b00991⟩ Article dans une revue hal-01187307v1
A robust and rapid xenograft model to assess efficacy of chemotherapeutic agents for human acute myeloid leukemia E Saland,H Boutzen,R Castellano,L Pouyet,E Griessingeret al. Blood Cancer Journal, 2015, 5 (e297), ⟨10.1038/bcj.2015.19⟩ Article dans une revue hal-01219119v1
Accelerating small compounds discovery targeting protein-protein interaction S. Milhas,S. Betzi,P. Roche,M. Cholay,A. Restouinet al. FEBS Journal, 2015, 282 (1, SI), pp.134 Article dans une revue hal-01439038v1
Context-selective death of acute myeloid leukemia cells triggered by the novel hybrid retinoid-HDAC inhibitor MC2392 L. Altucci,F. de Bellis,V. Carafa,M. Conte,D. Rotiliet al. Cancer Research, 2014, 74 (8), pp.2328-39. ⟨10.1158/0008-5472.CAN-13-2568⟩ Article dans une revue hal-03653834v1
CD95L cell surface cleavage triggers a pro-metastatic signaling pathway in triple negative breast cancer. Marine Malleter,Sebastien Tauzin,Alban Bessede,Remy Castellano,Armelle Goubardet al. Cancer Research, 2013, 73 (22), pp.6711-21. ⟨10.1158/0008-5472.CAN-13-1794⟩ Article dans une revue hal-00873634v1
The Histone Deacetylase Inhibitor Abexinostat Induces Cancer Stem Cells Differentiation in Breast Cancer with Low Xist Expression Marion A. Salvador,Julien Wicinski,Olivier Cabaud,Yves Toiron,Pascal Finettiet al. Clinical Cancer Research, 2013, 19 (23), pp.6520-6531. ⟨10.1158/1078-0432.CCR-13-0877⟩ Article dans une revue hal-01431936v1
Stereoselective synthesis of original spirolactams displaying promising folded structures. Guilhem Chaubet,Thibault Coursindel,Xavier Morelli,Stéphane Betzi,Philippe Rocheet al. Organic & Biomolecular Chemistry, 2013, 11 (28), pp.4719-26. ⟨10.1039/c3ob40643a⟩ Article dans une revue hal-00871067v1
Structural recognition mechanisms between human Src homology domain 3 (SH3) and ALG-2-interacting protein X (Alix) Xiaoli Shi,Stéphane Betzi,Adrien Lugari,Sandrine Opi,Audrey Restouinet al. FEBS Letters, 2012, 586, pp.1759-1764. ⟨10.1016/j.febslet.2012.05.017⟩ Article dans une revue hal-00717171v1
Human V 9V 2 T Cells Specifically Recognize and Kill Acute Myeloid Leukemic Blasts J. Gertner-Dardenne,R. Castellano,Emilie Mamessier,S. Garbit,E. Kochbatiet al. Journal of Immunology, 2012, 188 (9), pp.4701 - 4708. ⟨10.4049/jimmunol.1103710⟩ Article dans une revue hal-01765650v1
Stereoselective ring contraction of 2,5-diketopiperazines : An innovative approach to the synthesis of promising bioactive 5-membered scaffolds Thilbault Coursindel,Audrey Restouin,Georges Dewynter,Jean Martinez,Yves Colletteet al. Bioorganic Chemistry, 2010, 38, pp.210-217. ⟨10.1016/j.bioorg.2010.05.002⟩ Article dans une revue istex hal-00599350v1
Identification and biophysical assessment of the molecular recognition mechanisms between the human haemopoietic cell kinase Src homology domain and ALG-2-interacting protein X Xiaoli Shi,Sandrine Opi,Adrien Lugari,Audrey Restouin,Thibault Coursindelet al. Biochemical Journal, 2010, 431, pp.93-102. ⟨10.1042/BJ20100314⟩ Article dans une revue hal-00600207v1
Identification and biophysical assessment of the molecular recognition mechanisms between the human hemopoietic cell kinase Src homology domain 3 and ALG-2-interacting protein X Xiaoli Shi,Sandrine Opi,Adrien Lugari,Audrey Restouin,Thibault Coursindelet al. Biochemical Journal, 2010, 431 (1), pp.93-102. ⟨10.1042/BJ20100314⟩ Article dans une revue hal-00517249v1
Synergistic activation of HIV-1 expression by deacetylase inhibitors and prostratin: implications for treatment of latent infection. Sophie Reuse,Miriam Calao,Kabamba Kabeya,Allan Guiguen,Jean-Stéphane Gatotet al. PLoS ONE, 2009, 4 (6), pp.e6093. ⟨10.1371/journal.pone.0006093⟩ Article dans une revue hal-00464770v1
Protein protein interaction inhibition (2P2I) combining high throughput and virtual screening: Application to the HIV-1 Nef protein. Stéphane Betzi,Audrey Restouin,Sandrine Opi,Stefan T Arold,Isabelle Parrotet al. Proceedings of the National Academy of Sciences of the United States of America, 2007, 104 (49), pp.19256-61. ⟨10.1073/pnas.0707130104⟩ Article dans une revue hal-00473817v1
Amine guanidine switch : a promising approach to improve DNA binding and antiproliferative activities. K. Ohara,M. Smietana,A. Restouin,S. Mollard,J.-P. Borget al. Journal of Medicinal Chemistry, 2007, 50, pp.6465-6475. ⟨10.1021/jm701207m⟩ Article dans une revue hal-00346603v1
Parameters involved in the recognition of fresh human leukemic blasts by tumor-specific cytolytic T cell clones: a model study Hervé Chambost,Yves Collette,Hélène Dutartre,Isabelle Thuret,Daniel Olive Leukemia Research, 2000, 24 (10), pp.823-830. ⟨10.1016/s0145-2126(00)00053-9⟩ Article dans une revue istex hal-02459277v1
Human immunodeficiency virus type 1 Nef protein sensitizes CD4(+) T lymphoid cells to apoptosis via functional upregulation of the CD95/CD95 ligand pathway. G Zauli,D Gibellini,P Secchiero,H Dutartre,D Oliveet al. Blood, 1999, 93 (3), pp.1000-10 Article dans une revue hal-02459371v1
Simian immunodeficiency virus and human immunodeficiency virus type 1 nef proteins show distinct patterns and mechanisms of Src kinase activation. A Greenway,H Dutartre,K Allen,D Mcphee,D Oliveet al. Journal of Virology, 1999, 73 (7), pp.6152-8 Article dans une revue hal-02459367v1
Full Peptide Synthesis, Purification, and Characterization of Six Tat Variants Jean-Marie Peloponese,Yves Collette,Catherine Grégoire,Christian Bailly,Daniel Campèseet al. Journal of Biological Chemistry, 1999, 274 (17), pp.11473-11478. ⟨10.1074/jbc.274.17.11473⟩ Article dans une revue hal-02137983v1
The Human Immunodeficiency Virus Type 1 NEF Protein Binds the Src-Related Tyrosine Kinase Lck SH2 Domain Through a Novel Phosphotyrosine Independent Mechanism Hélène Dutartre,Mark Harris,Daniel Olive,Yves Collette Virology, 1998, 247 (2), pp.200-211. ⟨10.1006/viro.1998.9244⟩ Article dans une revue hal-02459372v1
The role of HIV1 Nef in T-cell activation: Nef impairs induction of Th1 cytokines and interacts with the Src family tyrosine kinase Lck Y. Collette,H. Dutartre,A. Benziane,D. Olive Research in virology, 1997, 148 (1), pp.52-58. ⟨10.1016/s0923-2516(97)81914-0⟩ Article dans une revue istex hal-02459374v1
Similarity between Nef of primate lentiviruses and p15E of murine and feline leukaemia viruses Y. Collette,H. Dutartre,A. Benziane,D. Olive,V. Collette AIDS. Official journal of the international AIDS Society, 1996, 10 (4), pp.441. ⟨10.1097/00002030-199604000-00013⟩ Article dans une revue hal-02459381v1

Poster de conférence (1)

Engineering new cellular models to decipher H3.3K27M mutation role in DIPGs' resistance to therapies Andria Rakotomalala,Paul Lewandowski,Quentin Bailleul,Clara Savary,Mélanie Arcicasaet al. AACR annual meeting, Apr 2022, New orleans, United States Poster de conférence hal-04535637v1

Chapitre d'ouvrage (1)

On Object-Oriented Programming of Optimizers - Examples in Scilab Y. Collette,Nikolaus Hansen,Gilles Pujol,Daniel Salazar Aponte,Rodolphe Le Riche Rajan Filomeno Coelho and Piotr Breitkopf. Multidisciplinary Design Optimization in Computational Mechanics, Wiley, pp. 499-538, 2010 Chapitre d'ouvrage inria-00476172v1

Pré-publication, Document de travail (1)

Combinatory therapy targeting mitochondrial oxidative phosphorylation improves efficacy of IDH mutant inhibitors in acute myeloid leukemia Lucille Stuani,Marie Sabatier,Feng Wang,Nathalie Poupin,Claudie Boscet al. 2020 Pré-publication, Document de travail hal-02935177v1