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Yves Le Loir



**Yves Le Loir** is a research scientist working at the French National Institute for Agricultural Research (INRA). He dedicates his scientific carrier to the microbiology of the milk production chain (with food and veterinary aspects). He originally studied Biochemistry at the University of Rennes (France). In 1992, he passed the diploma of Engineer in Agronomy of the Ecole Nationale Supérieure d’Agronomie (ENSA), in Rennes. He moved to INRA Jouy en Josas, France, (Unit of Microbial Genetics, headed by S.D. Ehrlich) to work on conjugative DNA transfer in *Lactococcus lactis*, the model lactic acid bacterium (LAB). He stayed in the same team to prepare a PhD thesis (University of Paris XI) in Microbiology on heterologous proteins secretion in *L. lactis*. He defended in 1996 and was recruited in INRA to go on working on protein secretion and lately on respiration in *L. lactis*. In February 2001, Y. Le Loir moved to INRA Rennes to start a new laboratory (Unit of Microbiology, INRA ENSA, Rennes, France). His new projects focused on host adaptation (ruminants) in *Staphylococcus aureus* and interactions between *Staphylococcus aureus* and Lactic Acid Bacteria. In 2008-2016, he headed a research team (12 permanent positions) called Bacterial Biodiversity and In Situ Interactions. From 2011 to 2016, he was alos deputy director of the Research Unit STLO. Since January 2017, he is heading the STLO Unit in Rennes. **STLO (Science and Technology of Milk & Eggs)** is a joint research unit comprising INRA and Agrocampus Ouest staff members (83 permanent positions, 130-140 staff). Since 2000, Y. Le Loir tightly collaborates with Pr Vasco Azevedo (UFMG, Belo Horizonte) and he has been Pesquisador Visitante Especial at UFMG in 2014-2016 (PVE400721/2013-9; CNPq). He also coordinates an International Associated Laboratory involving STLO and Micalis Research Units at INRA and 3 research teams at UFMG, in Brazil.


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Two human milk–like synthetic bacterial communities displayed contrasted impacts on barrier and immune responses in an intestinal quadricellular model

Charles Le Bras , Lucie Rault , Nolwenn Jacquet , Nathalie Daniel , Victoria Chuat
ISME Communications, 2024, 4 (1), pp.ycad019. ⟨10.1093/ismeco/ycad019⟩
Journal articles hal-04483180v1
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Recombinant probiotic Lactococcus lactis delivering P62 mitigates moderate colitis in mice

Juliana Guimarães Laguna , Andria dos Santos Freitas , Fernanda Alvarenga Lima Barroso , Luís Cláudio Lima de Jesus , Octávio Augusto Greco Gomes de Vasconcelos
Frontiers in Microbiology, 2024, 15, ⟨10.3389/fmicb.2024.1309160⟩
Journal articles hal-04536979v1
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Propionibacterium freudenreichii CIRM-BIA 129 mitigates colitis through S layer protein B-dependent epithelial strengthening. P. freudenreichii inhibits inflammation-induced epithelial break-down

Marine Mantel , Tony Durand , Anne Bessard , Ségolène Pernet , Julie Beaudeau
American Journal of Physiology-Gastrointestinal and Liver Physiology, 2024, 326 (2), pp.163-175. ⟨10.1152/ajpgi.00198.2023⟩
Journal articles hal-04322697v1
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Unlocking the Potential of Probiotics: A Comprehensive Review on Research, Production, and Regulation of Probiotics

Tales Fernando da Silva , Rafael de Assis Glória , Monique Ferrary Americo , Andria dos Santos Freitas , Luis Claudio Lima de Jesus
Probiotics and Antimicrobial Proteins, 2024, ⟨10.1007/s12602-024-10247-x⟩
Journal articles hal-04531737v1
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Fat matters: Fermented whole milk potentiates the anti-colitis effect of Propionibacterium freudenreichii

Marine Mantel , Tales Fernando da Silva , Rafael Gloria , Danièle Vassaux , Kátia Duarte Vital
Journal of Functional Foods, 2023, 106, pp.105614. ⟨10.1016/j.jff.2023.105614⟩
Journal articles hal-04140817v1