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zeynep baharoglu



**EDUCATION AND TRAINING** 2020 sept. HDR, Sorbonne Université, Paris 2008-2013 Post-doc in microbial genetics, Institut Pasteur 2005-2008 PhD thesis, Microbial Genetics, CGM-CNRS, Gif-sur-Yvette, UPMC 2005 Masters degree, Microbiology, University of Paris VII Diderot 2004 Undergraduate degree, Cell and Integrative Biology, University of Grenoble I, in exchange program with University of California Irvine **POSITIONS** 2021 jan Chef de groupe "Bacterial responses to antimicrobial stress" at *Unité Plasticité du génome bactérien - Institut Pasteur.* 2017-present Chargée de recherche expert at *Unité Plasticité du génome bactérien - Institut Pasteur* 2014-2017 Chargée de recherche at *Unité Plasticité du génome bactérien - Institut Pasteur.* 2008-2013 Postdoctoral researcher. *Unité Plasticité du génome bactérien - Institut Pasteur* 2005-2008 Doctoral research fellow in Microbiology at *Centre de Génétique Moléculaire – CNRS. Gif-sur-Yvette. Université Paris 6. Collaboration with University* College London **SCIENTIFIC ACTIVITIES** 19 publications (11 as first author, 3 articles as last author, 3 articles as corresponding author) 11 poster and 5 oral presentations in scientific meetings.


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Systematic transcriptome analysis allows the identification of new type I and type II Toxin/Antitoxin systems located in the superintegron of Vibrio cholerae

Evelyne Krin , Zeynep Baharoglu , Odile Sismeiro , Hugo Varet , Jean-Yves Coppée
Research in Microbiology, 2023, 174 (1-2), pp.103997. ⟨10.1016/j.resmic.2022.103997⟩
Journal articles pasteur-03889562v1
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A qnr-plasmid allows aminoglycosides to induce SOS in Escherichia coli

Anamaria Babosan , David Skurnik , Anaëlle Muggeo , Gerald Pier , Zeynep Baharoglu
eLife, 2022, 11, ⟨10.7554/eLife.69511⟩
Journal articles hal-03919325v1
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Non-essential tRNA and rRNA modifications impact the bacterial response to sub-MIC antibiotic stress

Anamaria Babosan , Louna Fruchard , Evelyne Krin , André Carvalho , Didier Mazel
microLife, 2022, 3, pp.uqac019. ⟨10.1093/femsml/uqac019⟩
Journal articles pasteur-03897869v2
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Deficiency in cytosine DNA methylation leads to high chaperonin expression and tolerance to aminoglycosides in Vibrio cholerae

André Carvalho , Didier Mazel , Zeynep Baharoglu
PLoS Genetics, 2021, 17 (10), pp.e1009748. ⟨10.1371/journal.pgen.1009748⟩
Journal articles pasteur-03417428v2
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Interplay between Sublethal Aminoglycosides and Quorum Sensing: Consequences on Survival in V. cholerae

André Carvalho , Evelyne Krin , Chloé Korlowski , Didier Mazel , Zeynep Baharoglu
Cells, 2021, 10 (11), pp.3227. ⟨10.3390/cells10113227⟩
Journal articles pasteur-03443810v2
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Sleeping ribosomes: bacterial signaling triggers RaiA mediated persistence to aminoglycosides

Manon Lang , Evelyne Krin , Chloé Korlowski , Odile Sismeiro , Hugo Varet
iScience, 2021, pp.103128. ⟨10.1016/j.isci.2021.103128⟩
Journal articles pasteur-03349141v1
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RadD Contributes to R-Loop Avoidance in Sub-MIC Tobramycin

Veronica Negro , Evelyne Krin , Sebastian Aguilar Pierlé , Thibault Chaze , Quentin Giai Gianetto
mBio, 2019, 10 (4), pp.e01173-19. ⟨10.1128/mBio.01173-19⟩
Journal articles pasteur-02171194v1
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SOS, the formidable strategy of bacteria against aggressions

Zeynep Baharoglu , Didier Mazel
FEMS Microbiology Reviews, 2014, 38 (6), pp.1126-1145. ⟨10.1111/1574-6976.12077⟩
Journal articles pasteur-01423593v1
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Identification of genes involved in low aminoglycoside-induced SOS response in Vibrio cholerae: a role for transcription stalling and Mfd helicase.

Z. Baharoglu , A. Babosan , D. Mazel
Nucleic Acids Research, 2014, 42 (4), pp.2366-2379. ⟨10.1093/nar/gkt1259⟩
Journal articles pasteur-01423602v1
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Influence of very short patch mismatch repair on SOS inducing lesions after aminoglycoside treatment in Escherichia coli.

Zeynep Baharoglu , Didier Mazel
Research in Microbiology, 2014, 165 (6), pp.476-80. ⟨10.1016/j.resmic.2014.05.039⟩
Journal articles pasteur-01423361v1
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β-lactam antibiotics promote bacterial mutagenesis via an RpoS-mediated reduction in replication fidelity

A. Gutierrez , L. Laureti , S. Crussard , H. Abida , A. Rodríguez-Rojas
Nature Communications, 2013, 4, pp.1610. ⟨10.1038/ncomms2607⟩
Journal articles pasteur-01691736v1
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RpoS Plays a Central Role in the SOS Induction by Sub-Lethal Aminoglycoside Concentrations in Vibrio cholerae

Zeynep Baharoglu , Evelyne Krin , Didier Mazel
PLoS Genetics, 2013, 9 (4), pp.e1003421. ⟨10.1371/journal.pgen.1003421⟩
Journal articles pasteur-01691109v1
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Multiple Pathways of Genome Plasticity Leading to Development of Antibiotic Resistance

Zeynep Baharoglu , Geneviève Garriss , Didier Mazel
Antibiotics, 2013, Antibiotic Resistance, 2 (2), pp.288-315. ⟨10.3390/antibiotics2020288⟩
Journal articles pasteur-01691592v1
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Connecting Environment and Genome Plasticity in the Characterization of Transformation-Induced SOS Regulation and Carbon Catabolite Control of the Vibrio cholerae Integron Integrase

Zeynep Baharoglu , Evelyne Krin , Didier Mazel
Journal of Bacteriology, 2012, 194 (7), pp.1659-1667. ⟨10.1128/JB.05982-11⟩
Journal articles pasteur-03941970v1
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Vibrio cholerae triggers SOS and mutagenesis in response to a wide range of antibiotics: a route towards multiresistance.

Zeynep Baharoglu , Didier Mazel
Antimicrobial Agents and Chemotherapy, 2011, 55 (5), pp.2438-2441. ⟨10.1128/AAC.01549-10⟩
Journal articles pasteur-01423615v1
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Conjugative DNA transfer induces the bacterial SOS response and promotes antibiotic resistance development through integron activation

Zeynep Baharoglu , David Bikard , Didier Mazel
PLoS Genetics, 2010, 6 (10), pp.e1001165. ⟨10.1371/journal.pgen.1001165⟩
Journal articles pasteur-02477623v1
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Folded DNA in Action: Hairpin Formation and Biological Functions in Prokaryotes

David Bikard , Céline Loot , Zeynep Baharoglu , Didier Mazel
Microbiology and Molecular Biology Reviews, 2010, 74 (4), pp.570-588. ⟨10.1128/MMBR.00026-10⟩
Journal articles pasteur-02505407v1
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RNA polymerase mutations that facilitate replication progression in the rep uvrD recF mutant lacking two accessory replicative helicases

Zeynep Baharoglu , Roxane Lestini , Stéphane Duigou , Bénédicte Michel
Molecular Microbiology, 2010, 77 (2), pp.324. ⟨10.1111/j.1365-2958.2010.07208.x⟩
Journal articles hal-00552639v1

Recombination proteins and rescue of arrested replication forks.

Bénédicte Michel , Hasna Boubakri , Zeynep Baharoglu , Marie Lemasson , Roxane Lestini
DNA Repair, 2007, 6 (7), pp.967-80. ⟨10.1016/j.dnarep.2007.02.016⟩
Journal articles hal-00167418v1

RuvAB is essential for replication forks reversal in certain replication mutants.

Zeynep Baharoglu , Mirjana Petranovic , Maria-Jose Flores , Bénédicte Michel
EMBO Journal, 2006, 25 (3), pp.596-604. ⟨10.1038/sj.emboj.7600941⟩
Journal articles hal-00130946v1