zeynep baharoglu

Présentation

EDUCATION AND TRAINING

2020 sept. HDR, Sorbonne Université, Paris

2008-2013 Post-doc in microbial genetics, Institut Pasteur

2005-2008 PhD thesis, Microbial Genetics, CGM-CNRS, Gif-sur-Yvette, UPMC

2005 Masters degree, Microbiology, University of Paris VII Diderot

2004 Undergraduate degree, Cell and Integrative Biology, University of Grenoble I, in exchange program with University of California Irvine

POSITIONS

2021 jan Chef de groupe &quot;Bacterial responses to antimicrobial stress&quot; at Unité Plasticité du génome bactérien - Institut Pasteur.

2017-present Chargée de recherche expert at Unité Plasticité du génome bactérien - Institut Pasteur

2014-2017 Chargée de recherche at Unité Plasticité du génome bactérien - Institut Pasteur.

2008-2013 Postdoctoral researcher. Unité Plasticité du génome bactérien - Institut Pasteur

2005-2008 Doctoral research fellow in Microbiology at Centre de Génétique Moléculaire – CNRS. Gif-sur-Yvette. Université Paris 6. Collaboration with University College London

SCIENTIFIC ACTIVITIES

19 publications (11 as first author, 3 articles as last author, 3 articles as corresponding author)

11 poster and 5 oral presentations in scientific meetings.

Publications

Article dans une revue (30)

Uridine as a potentiator of aminoglycosides through activation of carbohydrate transporters Manon Lang,Stéphane Renard,Imane El-Meouche,Ariane Amoura,Erick Denamuret al. Science Advances , 2025, 11 (36), pp.eadw7630. ⟨10.1126/sciadv.adw7630⟩ Article dans une revue pasteur-05347101v1
Aminoglycoside tolerance in Vibrio cholerae engages translational reprogramming associated with queuosine tRNA modification Louna Fruchard,Anamaria Babosan,Andre Carvalho,Manon Lang,Blaise Liet al. eLife, 2025, 13, pp.RP96317. ⟨10.7554/eLife.96317.3⟩ Article dans une revue hal-05029047v1
Beyond RNA modification: a novel role for tRNA modifying enzyme in oxidative stress response and metabolism Louna Fruchard,Claudia Sudol,Caroline Rouard,Aurore Treffkorn-Maurau,Léo Hardyet al. Nucleic Acids Research, 2025, 53 (22), pp.gkaf1276. ⟨10.1093/nar/gkaf1276⟩ Article dans une revue pasteur-05438616v1
The tRNA epitranscriptomic landscape and RNA modification enzymes in Vibrio cholerae Léo Hardy,Virginie Marchand,Valérie Bourguignon,Quentin Thuillier,Cathy Diaset al. PLoS Genetics, 2025, 21 (10), pp.e1011937. ⟨10.1371/journal.pgen.1011937⟩ Article dans une revue pasteur-05347080v1
tRNA-modifying enzymes in bacterial stress adaptation Louna Fruchard,Claudia Salinas,Andre Carvalho,Zeynep Baharoglu Open Biology, 2025, 15 (10), pp.250194. ⟨10.1098/rsob.250194⟩ Article dans une revue pasteur-05347156v1
Fine-tuning of a CRISPRi screen in the seventh pandemic Vibrio cholerae Kevin Debatisse,Théophile Niault,Sarah Peeters,Amandine Maire,Busra Toktaset al. BMC Genomics, 2024, 25 (1), pp.985. ⟨10.1186/s12864-024-10891-1⟩ Article dans une revue pasteur-05116026v1
Exploring a unique class of flavoenzymes: Identification and biochemical characterization of ribosomal RNA dihydrouridine synthase Sabrine Toubdji,Quentin Thullier,Lea-Marie Kilz,V. Marchand,Yifeng Yuanet al. Proceedings of the National Academy of Sciences of the United States of America, 2024, 121 (32), pp.e2401981121. ⟨10.1073/pnas.2401981121⟩ Article dans une revue hal-04734945v1
Measuring single-cell susceptibility to antibiotics within monoclonal bacterial populations Lena Le Quellec,Andrey Aristov,Salomé Gutiérrez Ramos,Gabriel Amselem,Julia Boset al. PLoS ONE, 2024, 19 (8), pp.e0303630. ⟨10.1371/journal.pone.0303630⟩ Article dans une revue pasteur-04739933v2
Systematic transcriptome analysis allows the identification of new type I and type II Toxin/Antitoxin systems located in the superintegron of Vibrio cholerae Evelyne Krin,Zeynep Baharoglu,Odile Sismeiro,Hugo Varet,Jean-Yves Coppéeet al. Research in Microbiology, 2023, 174 (1-2), pp.103997. ⟨10.1016/j.resmic.2022.103997⟩ Article dans une revue pasteur-03889562v1
RavA‐ViaA antibiotic response is linked to Cpx and Zra2 envelope stress systems in Vibrio cholerae Evelyne Krin,André Carvalho,Manon Lang,Anamaria Babosan,Didier Mazelet al. Microbiology Spectrum, 2023, 11 (6), pp.e01730-23. ⟨10.1128/spectrum.01730-23⟩ Article dans une revue pasteur-04260034v1
Aminoglycoside uptake, stress, and potentiation in Gram-negative bacteria: new therapies with old molecules Manon Lang,André Carvalho,Zeynep Baharoglu,Didier Mazel Microbiology and Molecular Biology Reviews, 2023, ⟨10.1128/mmbr.00036-22⟩ Article dans une revue pasteur-04334889v1
Non-essential tRNA and rRNA modifications impact the bacterial response to sub-MIC antibiotic stress Anamaria Babosan,Louna Fruchard,Evelyne Krin,André Carvalho,Didier Mazelet al. microLife, 2022, 3, pp.uqac019. ⟨10.1093/femsml/uqac019⟩ Article dans une revue pasteur-03897869v2
A qnr-plasmid allows aminoglycosides to induce SOS in Escherichia coli Anamaria Babosan,David Skurnik,Anaëlle Muggeo,Gerald Pier,Zeynep Baharogluet al. eLife, 2022, 11, ⟨10.7554/eLife.69511⟩ Article dans une revue hal-03919325v1
Interplay between Sublethal Aminoglycosides and Quorum Sensing: Consequences on Survival in V. cholerae André Carvalho,Evelyne Krin,Chloé Korlowski,Didier Mazel,Zeynep Baharoglu Cells, 2021, 10 (11), pp.3227. ⟨10.3390/cells10113227⟩ Article dans une revue pasteur-03443810v2
Deficiency in cytosine DNA methylation leads to high chaperonin expression and tolerance to aminoglycosides in Vibrio cholerae André Carvalho,Didier Mazel,Zeynep Baharoglu PLoS Genetics, 2021, 17 (10), pp.e1009748. ⟨10.1371/journal.pgen.1009748⟩ Article dans une revue pasteur-03417428v2
Sleeping ribosomes: bacterial signaling triggers RaiA mediated persistence to aminoglycosides Manon Lang,Evelyne Krin,Chloé Korlowski,Odile Sismeiro,Hugo Varetet al. iScience, 2021, pp.103128. ⟨10.1016/j.isci.2021.103128⟩ Article dans une revue pasteur-03349141v1
RadD Contributes to R-Loop Avoidance in Sub-MIC Tobramycin Veronica Negro,Evelyne Krin,Sebastian Aguilar Pierlé,Thibault Chaze,Quentin Giai Gianettoet al. mBio, 2019, 10 (4), pp.e01173-19. ⟨10.1128/mBio.01173-19⟩ Article dans une revue pasteur-02171194v1
Influence of very short patch mismatch repair on SOS inducing lesions after aminoglycoside treatment in Escherichia coli. Zeynep Baharoglu,Didier Mazel Research in Microbiology, 2014, 165 (6), pp.476-80. ⟨10.1016/j.resmic.2014.05.039⟩ Article dans une revue pasteur-01423361v1
Identification of genes involved in low aminoglycoside-induced SOS response in Vibrio cholerae: a role for transcription stalling and Mfd helicase. Z. Baharoglu,A. Babosan,D. Mazel Nucleic Acids Research, 2014, 42 (4), pp.2366-2379. ⟨10.1093/nar/gkt1259⟩ Article dans une revue pasteur-01423602v1
SOS, the formidable strategy of bacteria against aggressions Zeynep Baharoglu,Didier Mazel FEMS Microbiology Reviews, 2014, 38 (6), pp.1126-1145. ⟨10.1111/1574-6976.12077⟩ Article dans une revue pasteur-01423593v1
β-lactam antibiotics promote bacterial mutagenesis via an RpoS-mediated reduction in replication fidelity A. Gutierrez,L. Laureti,S. Crussard,H. Abida,A. Rodríguez-Rojaset al. Nature Communications, 2013, 4, pp.1610. ⟨10.1038/ncomms2607⟩ Article dans une revue pasteur-01691736v1
RpoS Plays a Central Role in the SOS Induction by Sub-Lethal Aminoglycoside Concentrations in Vibrio cholerae Zeynep Baharoglu,Evelyne Krin,Didier Mazel PLoS Genetics, 2013, 9 (4), pp.e1003421. ⟨10.1371/journal.pgen.1003421⟩ Article dans une revue pasteur-01691109v1
Multiple Pathways of Genome Plasticity Leading to Development of Antibiotic Resistance Zeynep Baharoglu,Geneviève Garriss,Didier Mazel Antibiotics, 2013, Antibiotic Resistance, 2 (2), pp.288-315. ⟨10.3390/antibiotics2020288⟩ Article dans une revue pasteur-01691592v1
Connecting Environment and Genome Plasticity in the Characterization of Transformation-Induced SOS Regulation and Carbon Catabolite Control of the Vibrio cholerae Integron Integrase Zeynep Baharoglu,Evelyne Krin,Didier Mazel Journal of Bacteriology, 2012, 194 (7), pp.1659-1667. ⟨10.1128/JB.05982-11⟩ Article dans une revue pasteur-03941970v1
Vibrio cholerae triggers SOS and mutagenesis in response to a wide range of antibiotics: a route towards multiresistance. Zeynep Baharoglu,Didier Mazel Antimicrobial Agents and Chemotherapy, 2011, 55 (5), pp.2438-2441. ⟨10.1128/AAC.01549-10⟩ Article dans une revue pasteur-01423615v1
RNA polymerase mutations that facilitate replication progression in the rep uvrD recF mutant lacking two accessory replicative helicases Zeynep Baharoglu,Roxane Lestini,Stéphane Duigou,Bénédicte Michel Molecular Microbiology, 2010, 77 (2), pp.324. ⟨10.1111/j.1365-2958.2010.07208.x⟩ Article dans une revue hal-00552639v1
Conjugative DNA transfer induces the bacterial SOS response and promotes antibiotic resistance development through integron activation Zeynep Baharoglu,David Bikard,Didier Mazel PLoS Genetics, 2010, 6 (10), pp.e1001165. ⟨10.1371/journal.pgen.1001165⟩ Article dans une revue pasteur-02477623v1
Folded DNA in Action: Hairpin Formation and Biological Functions in Prokaryotes David Bikard,Céline Loot,Zeynep Baharoglu,Didier Mazel Microbiology and Molecular Biology Reviews, 2010, 74 (4), pp.570-588. ⟨10.1128/MMBR.00026-10⟩ Article dans une revue pasteur-02505407v1
Recombination proteins and rescue of arrested replication forks. Bénédicte Michel,Hasna Boubakri,Zeynep Baharoglu,Marie Lemasson,Roxane Lestini DNA Repair, 2007, 6 (7), pp.967-80. ⟨10.1016/j.dnarep.2007.02.016⟩ Article dans une revue istex hal-00167418v1
RuvAB is essential for replication forks reversal in certain replication mutants. Zeynep Baharoglu,Mirjana Petranovic,Maria-Jose Flores,Bénédicte Michel EMBO Journal, 2006, 25 (3), pp.596-604. ⟨10.1038/sj.emboj.7600941⟩ Article dans une revue hal-00130946v1