zoubida karim

Publications

Article dans une revue (46)

Intestinal hepcidin overexpression promotes iron deficiency anemia and counteracts iron overload via DMT1 downregulation Marion Falabrègue,Candice Aurrand,Léa Cazaulon,Nadia Boussetta,Sara Zumerleet al. Blood, 2025, ⟨10.1182/blood.2025028370⟩ Article dans une revue hal-05347161v1
Iron and energy metabolic interactions in Treg-mediated immune regulation Frédérique Savagner,Thomas Farge,Zoubida Karim,Meryem Aloulou Frontiers in Immunology, 2025, 16, pp.1554028. ⟨10.3389/fimmu.2025.1554028⟩ Article dans une revue hal-05378486v1
Editorial: Ironome: a still untapped frontier Gloria C Ferreira,Vladimir N Uversky,Zoubida Karim Frontiers in Molecular Biosciences, 2025, 12, pp.1651154. ⟨10.3389/fmolb.2025.1651154⟩ Article dans une revue hal-05378482v1
Identification of a neuron-specific ferroptosis in the neurodegenerative mucopolysaccharidosis III model Mathilde Larribau,Myriam Rouahi,Christophe Santiago,Jérôme Ausseil,Zoubida Karim Frontiers in Molecular Biosciences, 2025, 12, pp.1476513. ⟨10.3389/fmolb.2025.1476513⟩ Article dans une revue hal-05376668v1
Cutaneous leishmaniasis and iron metabolism: current insights and challenges Aicha Assouab,Ayyoub Kihel,Myriam Rouahi,Mathilde Larribau,Zoubida Karimet al. Frontiers in Immunology, 2024, 15, pp.1488590. ⟨10.3389/fimmu.2024.1488590⟩ Article dans une revue hal-05045859v1
Skin hepcidin initiates psoriasiform skin inflammation via Fe-driven hyperproliferation and neutrophil recruitment Elise Abboud,Doha Chrayteh,Nadia Boussetta,Héloise Dalle,Mariangela Malerbaet al. Nature Communications, 2024, 15, pp.6718. ⟨10.1038/s41467-024-50993-8⟩ Article dans une revue hal-05045889v1
Crosstalk between Acidosis and Iron Metabolism: Data from In Vivo Studies Raêd Daher,Nicolas Ducrot,Thibaud Lefebvre,Sofia Zineeddine,Jérome Ausseilet al. Metabolites, 2022, 12 (2), pp.89. ⟨10.3390/metabo12020089⟩ Article dans une revue inserm-03874980v1
Kinetics of serum hepcidin and interleukin-6 levels following COVID-19 infection in hemodialysis patients Maxime Touzot,Thibaud Lefebvre,Catherine Maheas,Katell Peoc'H,Pablo Ureña-Torreset al. Clinical Kidney Journal, 2022, 15 (3), pp.582-583. ⟨10.1093/ckj/sfab254⟩ Article dans une revue hal-03764736v1
Luspatercept (RAP-536) modulates oxidative stress without affecting mutation burden in myelodysplastic syndromes Meunier Mathieu,Chloé Friedrich,Nicolas Ducrot,Johanna Zannoni,Tondeur Sylvieet al. Annals of Hematology, 2022, 101 (12), pp.2633-2643. ⟨10.1007/s00277-022-04993-7⟩ Article dans une revue inserm-03874959v1
IRE-dependent Regulation of Intestinal Dmt1 Prevails During Chronic Dietary Iron Deficiency but is Dispensable in Conditions of Acute Erythropoietic Stress Maria Qatato,Michael Bonadonna,Gaël Palais,Alina Ertl,Gabriele Schmidtet al. HemaSphere, 2022, 6 (3), pp.e693. ⟨10.1097/HS9.0000000000000693⟩ Article dans une revue inserm-03874988v1
ABCB6 Polymorphisms are not Overly Represented in Patients with Porphyria Colin P Farrell,Gaël Nicolas,Robert Desnick,Charles J Parker,Jerome Lamorilet al. Blood Advances, 2022, 6 (3), pp.760-766. ⟨10.1182/bloodadvances.2021005484⟩ Article dans une revue hal-03483658v2
Prevalence of HFE-related haemochromatosis and secondary causes of hyperferritinaemia and their association with iron overload in 1059 French patients treated by venesection Gérald Le Gac,Virginie Scotet,Isabelle Gourlaouen,Carine L'Hostis,Marie-Christine Merouret al. Alimentary Pharmacology & Therapeutics, 2022, 55 (8), pp.1016-1027. ⟨10.1111/apt.16775⟩ Article dans une revue hal-03592561v1
Hepcidin and Iron Deficiency in Women One Year after Sleeve Gastrectomy Thibaud Lefebvre,Muriel Coupaye,Marina Esposito-Farèse,Nathalie Gault,Neila Talbiet al. Nutrients, 2021, 13 (8), pp.2516. ⟨10.3390/nu13082516⟩ Article dans une revue hal-03448937v1
A hepcidin‐based approach for iron therapy in hemodialysis patients: A pilot study Maxime Touzot,Thibaud Lefebvre,Catherine Maheas,Christophe Ridel,Hervé Puyet al. Hemodialysis International, 2020, 24 (2), pp.188-194. ⟨10.1111/hdi.12823⟩ Article dans une revue hal-03046316v1
Iron chelation rescues hemolytic anemia and skin photosensitivity in congenital erythropoietic porphyria Jean-Marc Blouin,Cécile Ged,Magalie Lalanne,Isabelle Lamrissi-Garcia,Fanny Morice-Picardet al. Blood, 2020, 136 (21), pp.2457-2468. ⟨10.1182/blood.2020006037⟩ Article dans une revue hal-03045807v1
Control of Systemic Iron Homeostasis by the 3’ Iron-Responsive Element of Divalent Metal Transporter 1 in Mice Elisabeth Tybl,Hiromi Gunshin,Sanjay Gupta,Tomasa Barrientos,Michael Bonadonnaet al. HemaSphere, 2020, 4 (5), pp.e459. ⟨10.1097/HS9.0000000000000459⟩ Article dans une revue hal-03043109v1
A variant erythroferrone disrupts iron homeostasis in SF3B1-mutated myelodysplastic syndrome Sabrina Bondu,Anne-Sophie Alary,Carine Lefevre,Alexandre Houy,Grace Junget al. Science Translational Medicine, 2019, 11 (500), pp.eaav5467. ⟨10.1126/scitranslmed.aav5467⟩ Article dans une revue inserm-02449216v1
Regulation and tissue-specific expression of δ-aminolevulinic acid synthases in non-syndromic sideroblastic anemias and porphyrias Katell Peoc'H,Gaël Nicolas,Caroline Schmitt,Arienne Mirmiran,Raed Daheret al. Molecular Genetics and Metabolism, 2019, ⟨10.1016/j.ymgme.2019.01.015⟩ Article dans une revue hal-02351175v1
Genetic background influences hepcidin response to iron imbalance in a mouse model of hemolytic anemia (Congenital erythropoietic porphyria) Thibaud Lefebvre,Sarah Millot,Emmanuel Richard,Jean-Marc Blouin,Magalie Lalanneet al. Biochemical and Biophysical Research Communications, 2019, 520 (2), pp.297-303. ⟨10.1016/j.bbrc.2019.09.141⟩ Article dans une revue hal-03046353v1
Extrahepatic hepcidin production: The intriguing outcomes of recent years Raêd Daher,Thibaud Lefebvre,Hervé Puy,Zoubida Karim World Journal of Clinical Cases, 2019, 7 (15), pp.1926-1936. ⟨10.12998/wjcc.v7.i15.1926⟩ Article dans une revue hal-03046342v1
GLRX5 mutations impair heme biosynthetic enzymes ALA synthase 2 and ferrochelatase in Human congenital sideroblastic anemia Raed Daher,Abdellah Mansouri,Alain Martelli,Sophie Bayart,Hana Manceauet al. Molecular Genetics and Metabolism, 2019, ⟨10.1016/j.ymgme.2018.12.012⟩ Article dans une revue hal-02351427v1
Regulation of globin-heme balance in Diamond-Blackfan anemia by HSP70/GATA1 Sarah Rio,Marc Gastou,Narjesse Karboul,Raphaёl Derman,Thunwarat Suriyunet al. Blood, 2019, 133 (12), pp.1358-1370. ⟨10.1182/blood-2018-09-875674⟩ Article dans une revue hal-02339695v1
Regulation and tissue-specific expression of δ-aminolevulinic acid synthases in non-syndromic sideroblastic anemias and porphyrias Katell Peoc'H,Gaël Nicolas,Caroline Schmitt,Arienne Mirmiran,Raed Daheret al. Molecular Genetics and Metabolism, 2019, ⟨10.1016/j.ymgme.2019.01.015⟩ Article dans une revue inserm-02075450v1
Functional erythropoietin‐hepcidin axis in recombinant human erythropoietin independent haemodialysis patients Maxime Touzot,Thibaud Lefebvre,Arthur Roux,Catherine Maheas,Christophe Ridelet al. Nephrology, 2019, 24 (7), pp.751-757. ⟨10.1111/nep.13485⟩ Article dans une revue hal-02351435v1
Genetic background influences hepcidin response to iron imbalance in a mouse model of hemolytic anemia (Congenital erythropoietic porphyria) Zoubida Karim Biochemical and Biophysical Research Communications, In press, ⟨10.1016/j.bbrc.2019.09.141⟩ Article dans une revue hal-02350852v1
Dyserythropoiesis evaluated by the RED score and hepcidin:ferritin ratio predicts response to erythropoietin in lower-risk myelodysplastic syndromes Sophie Park,Olivier Kosmider,Fréderic Maloisel,Bernard Drénou,Nicolas Chapuiset al. Haematologica, 2019, 104 (3), pp.497-504. ⟨10.3324/haematol.2018.203158⟩ Article dans une revue hal-02351432v1
Erythroid-Progenitor-Targeted Gene Therapy Using Bifunctional TFR1 Ligand-Peptides in Human Erythropoietic Protoporphyria Arienne Mirmiran,Caroline Schmitt,Thibaud Lefebvre,Hana Manceau,Raed Daheret al. American Journal of Human Genetics, 2019, 104 (2), pp.341-347. ⟨10.1016/j.ajhg.2018.12.021⟩ Article dans une revue hal-02328937v1
Extrahepatic hepcidin production: The intriguing outcomes of recent years Raed Daher,Thibaud Lefebvre,Hervé Puy,Zoubida Karim World Journal of Clinical Cases, 2019, 7 (15), pp.1926-1936. ⟨10.12998/wjcc.v7.i15.1926⟩ Article dans une revue hal-02350928v1
The Relevancy of Data Regarding the Metabolism of Iron to Our Understanding of Deregulated Mechanisms in ALS; Hypotheses and Pitfalls Camille Petillon,Rudolf Hergesheimer,Hervé Puy,Philippe Corcia,Patrick Vourc’het al. Frontiers in Neuroscience, 2019, 12, pp.1031. ⟨10.3389/fnins.2018.01031⟩ Article dans une revue hal-02351424v1
Recurrent attacks of acute hepatic porphyria: major role of the chronic inflammatory response in the liver Caroline Schmitt,Hugo Lenglet,Angèle Yu,Constance Delaby,Arndt Beneckeet al. Journal of Internal Medicine, 2018, 284 (1), pp.78-91. ⟨10.1111/joim.12750⟩ Article dans une revue hal-02503870v1
Porphyria and kidney diseases Nicolas Pallet,Alexandre Karras,Eric Thervet,Laurent Gouya,Zoubida Karimet al. Clinical Kidney Journal, 2018, 11 (2), pp.191-197. ⟨10.1093/ckj/sfx146⟩ Article dans une revue hal-02351440v1
Involvement of hepcidin in iron metabolism dysregulation in Gaucher disease Thibaud Lefebvre,Niloofar Reihani,Raed Daher,Thierry Billette de Villemeur,Nadia Belmatouget al. Haematologica, 2018, 103 (4), pp.587-596. ⟨10.3324/haematol.2017.177816⟩ Article dans une revue hal-01762401v1
Hepatocellular carcinoma in acute hepatic porphyrias: A Damocles Sword Katell Peoc'H,Hana Manceau,Zoubida Karim,Staffan Wahlin,Laurent Gouyaet al. Molecular Genetics and Metabolism, 2018, ⟨10.1016/j.ymgme.2018.10.001⟩ Article dans une revue hal-02351428v1
Predominant role of microglia in brain iron retention in Sanfilippo syndrome, a pediatric neurodegenerative disease Vincent Puy,Walaa Darwiche,Stephanie Trudel,Cathy Gomila,Christelle Lonyet al. Glia, 2018, 66 (8), pp.1709-1723. ⟨10.1002/glia.23335⟩ Article dans une revue hal-02351442v1
From a dominant to an oligogenic model of inheritance with environmental modifiers in acute intermittent porphyria Hugo Lenglet,Caroline Schmitt,Thomas Grange,Hana Manceau,Narjesse Karboulet al. Human Molecular Genetics, 2018, 27 (7), pp.1164-1173. ⟨10.1093/hmg/ddy030⟩ Article dans une revue hal-02351445v1
Cardiac iron overload in chronically transfused patients with thalassemia, sickle cell anemia, or myelodysplastic syndrome Mariane de Montalembert,Jean-Antoine Ribeil,Valentine Brousse,Agnès Guerci-Bresler,Aspasia Stamatoullaset al. PLoS ONE, 2017, 12 (3), pp.e0172147. ⟨10.1371/journal.pone.0172147⟩ Article dans une revue hal-02377929v1
Mutation in human CLPX elevates levels of δ- aminolevulinate synthase and protoporphyrin IX to promote erythropoietic protoporphyria Yvette Yien,Sarah Ducamp,Lisa van Der Vorm,Julia Kardon,Hana Manceauet al. Proceedings of the National Academy of Sciences of the United States of America, 2017, 114 (38), pp.E8045-E8052. ⟨10.1073/pnas.1700632114⟩ Article dans une revue inserm-02075468v1
Iron metabolism and the role of the iron-regulating hormone hepcidin in health and disease Raed Daher,Hana Manceau,Zoubida Karim La Presse Médicale, 2017, 46 (12), pp.e272-e278. ⟨10.1016/j.lpm.2017.10.006⟩ Article dans une revue hal-02351459v1
Corrigendum to “Alteration of cerebral iron metabolism in Sanfilippo syndrome” [Mol. Genet. Metab. 117 2, February 2016, p. S97] Vincent Puy,Pierre-Edouard Bodet,Camille Rottier,Rémi Delaunay,Cathy Gomilaet al. Molecular Genetics and Metabolism, 2016, 118 (1), pp.64. ⟨10.1016/j.ymgme.2016.03.005⟩ Article dans une revue hal-02065247v1
Heterozygous Mutations in BMP6 Pro-peptide Lead to Inappropriate Hepcidin Synthesis and Moderate Iron Overload in Humans Raed Daher,Caroline Kannengiesser,Dounia Houamel,Thibaud Lefebvre,Edouard Bardou-Jacquetet al. Gastroenterology, 2016, 150 (3), pp.672-683. ⟨10.1053/j.gastro.2015.10.049⟩ Article dans une revue hal-01231430v1
The microbiota shifts the iron sensing of intestinal cells Jean-Christophe Deschemin,Marie-Louise M.-L. Noordine,Aude Remot,Alexandra Willemetz,Clément Afifet al. FASEB Journal, 2016, 30 (1), pp.252-261. ⟨10.1096/fj.15-276840⟩ Article dans une revue hal-02632319v1
Mitochondrial energetic defects in muscle and brain of a Hmbs-/- mouse model of acute intermittent porphyria Chadi Homedan,Caroline Schmitt,Jihane Laafi,Naïg Gueguen,Valérie Desquiret-Dumaset al. Human Molecular Genetics, 2015, 24 (17), pp.5015-23. ⟨10.1093/hmg/ddv222⟩ Article dans une revue hal-02056592v1
Iron Regulatory Protein 1 Sustains Mitochondrial Iron Loading and Function in Frataxin Deficiency Alain Martelli,Stephane Schmucker,Laurence Reutenauer,Jacques R.R. Mathieu,Carole Peyssonnauxet al. Cell Metabolism, 2015, 21 (2), pp.311-323. ⟨10.1016/j.cmet.2015.01.010⟩ Article dans une revue hal-04996861v1
High prevalence of and potential mechanisms for chronic kidney disease in patients with acute intermittent porphyria Nicolas Pallet,Iadh Mami,Caroline Schmitt,Zoubida Karim,Arnaud Françoiset al. Kidney International, 2015, 88 (2), pp.386-395. ⟨10.1038/ki.2015.97⟩ Article dans une revue hal-02317945v1
Acute intermittent porphyria causes hepatic mitochondrial energetic failure in a mouse model Chadi Homedan,Jihane Laafi,Caroline Schmitt,Naïg Gueguen,Thibaud Lefebvreet al. International Journal of Biochemistry and Cell Biology, 2014, 51, pp.93-101. ⟨10.1016/j.biocel.2014.03.032⟩ Article dans une revue istex hal-03328708v1
Protoporphyrin retention in hepatocytes and kupffer cells prevents sclerosing cholangitis in erythropoietic protoporphyria mouse model. Saïd Lyoumi,Marie Abitbol,Dominique Rainteau,Zoubida Karim,Florence Bernexet al. Gastroenterology, 2011, 141 ((4)), pp.1509-1519.e3. ⟨10.1053/j.gastro.2011.06.078⟩ Article dans une revue hal-00631510v1

Communication dans un congrès (2)

Intra-articular production of hepcidin in arthritis: a potential modulator of inflammatory osteoarticular pathogenesis C. Lamalle,M. Galindo,M. Masson,T. Lefebvre,L. Zabranieckiet al. European Congress of Rheumatology, Jun 2025, Barcelone, Spain. pp.330-331, ⟨10.1016/j.ard.2025.05.408⟩ Communication dans un congrès hal-05378504v1
Production intra-articulaire d’hepcidine dans l’arthrite : un potentiel modulateur de la pathogénie ostéo-articulaire inflammatoire C. Lamalle,M. Galindo,M. Masson,T. Lefebvre,L. Zabranieckiet al. 37e Congrès Français de Rhumatologie, Dec 2024, Paris, France. pp.A112-A113, ⟨10.1016/j.rhum.2024.10.411⟩ Communication dans un congrès hal-05378506v1

Poster de conférence (1)

A Phase 2 Prospective Study Evaluating Low-Dose Deferasirox in Patients with Low-Risk Myelodysplastic Syndrome Resistant or Relapsing after Erythropoietin Stimulating Agents (LODEFI) Meunier Mathieu,Sylvain Thépot,Stanislas Nimubona,Mélanie Veloso,Thibaud Lefebvreet al. The 66th ASH Annual Meeting, Oct 2024, San Diego (CA), United States. 144 (Supplement 1), pp.1826-1826, 2024, ⟨10.1182/blood-2024-198104⟩ Poster de conférence hal-04875903v1