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Alain Bruhat

Alain Bruhat -Directeur de Recherche INRAE
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**BRUHAT Alain** **Directeur de Recherche INRAE ** **ADRESSE PROFESSIONNELLE** UMR 1019-INRAE Université Clermont-Auvergne Centre INRAE de Theix 63122 Saint Genès Champanelle Tel : 04 73 62 41 50 Email : alain.bruhat@inrae.fr **TITRES UNIVERSITAIRES** Habilitation à Diriger les Recherches, Université d’Auvergne, Clermont-Fd. Doctorat de Biologie Cellulaire et Moléculaire (mention très honorable avec félicitations du jury), INSERM U384, Université Blaise Pascal, Clermont-Fd. **ACTIVITÉ DE RECHERCHE** 2011-actuel : Directeur de Recherche INRAE dans l’UMR 1019 INRAE/Université Clermont Auvergne (UCA) Unité de Nutrition Humaine à Theix, équipe PROTEOSTASIS. « Etude des mécanismes d’adaptation à un stress nutritionnel ». **PUBLICATIONS (articles à comité de lecture)** 71 publications internationales / h-index : 33 **VALORISATION-BREVETS** 2023 : Demande de brevet en cours (co-inventeur) intitulée “ INDUCING AN AMINO ACID DEFICIENCY BY AN IMBALANCE IN AMINO ACID INTAKE” ; demande de brevet No. 1000513036 2022 : Demande de brevet en cours (co-inventeur) intitulée “CONTROLLED EXPRESSION OF A THERAPEUTIC GENE IN HUMAN T LYMPHOCYTES FOR USE IN CELLULAR IMMUNOTHERAPY” ; demande de brevet européen No. 22306008.8 2021 : Demande de brevet en cours (co-inventeur) intitulée “CONTROLLED GENE THERAPY OF OCULAR DISEASES”. Demande de brevet européen No. 21305928.0 2016: Brevet (co-inventeur) intitulé « DIET CONTROLLED EXPRESSION OF A NUCLEIC ACID ENCODING A PRO-APOPTOTIC PROTEIN » US201662345162P·(2016-06-03); JP2019237502A·(2019-12-26); JP2020072699A·(2020-05-14). 2013: Brevet (co-inventeur) intitulé « CASSETTE D'EXPRESSION INDUCTIBLE ET SES UTILISATIONS ». FR2982277-A1 (10 May 2013); WO2013068096-A& (16 May 2013); EP2776568-A1 (17 Sep 2014); US2014322184-A1 (30 octobre 2014). **CRÉATION D’ENTREPRISE** 2017-actuel : Co-porteur de projet (2017-2019) puis co-membre fondateur et actionnaire (2019-actuel) de la start up NUTRITHERAGENE (ON-OFF THERAPEUTICS), incubée au sein de l’incubateur d’entreprise BUSI (63 Saint-Beauzire) et créée le 5 juin 2019 à Clermont-Fd. **ACTIVITÉ D’ENSEIGNEMENT** Co-responsable de l’UE « Molecular Nutrition » du Master M2 Biologie Santé, parcours Nutrition Health and Mobility de l’Université Clermont Auvergne (UCA). Programmation des enseignements, choix et correction des sujets d’examen, participation aux réunions pédagogiques avec les responsables des autres modules du M2 ainsi qu’aux jurys de soutenance de stage M2. Cours et travaux dirigés en anglais dans cet UE sur « Stress cellulaire, stress du réticulum endoplasmique et développement de pathologies associées ».

Research domains


Skills

Métabolisme des protéines et des acides aminés Adaptation cellulaire au stress nutritionnel Voie de signalisation GCN2-ATF4 Développement d'une techologie appelée NUTRIREG qui utilise la voie GCN2-ATF4 pour contrôler l'expression d'un transgène utilisable en thérapie génique

Publications

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Temporal regulation of transgene expression controlled by amino acid availability in human T cells

Aurore Dougé , Cyrielle Vituret , Valérie Carraro , Laurent Parry , Cécile Coudy-Gandilhon
HLA: Immune Response Genetics, 2024, Jan: 103 (1), pp.e15252. ⟨10.1111/tan.15252⟩
Journal articles hal-04214017v1
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Induction of ATF4-Regulated Atrogenes Is Uncoupled from Muscle Atrophy during Disuse in Halofuginone-Treated Mice and in Hibernating Brown Bears

Laura Cussonneau , Cécile Coudy-Gandilhon , Christiane Deval , Ghita Chaouki , Mehdi M. Djelloul-Mazouz
International Journal of Molecular Sciences, 2023, 24 (1), pp.621. ⟨10.3390/ijms24010621⟩
Journal articles hal-04178468v1
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Activation of the eIF2α-ATF4 Pathway by Chronic Paracetamol Treatment Is Prevented by Dietary Supplementation with Cysteine

Valérie Carraro , Lydie Combaret , Cécile Coudy-Gandilhon , Laurent Parry , Julien Averous
International Journal of Molecular Sciences, 2022, 23 (13), pp.7196. ⟨10.3390/ijms23137196⟩
Journal articles hal-03741978v1
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GCN2 upregulates autophagy in response to short-term deprivation of a single essential amino acid

Anne-Catherine Maurin , Laurent Parry , Wafa B’chir , Valérie Carraro , Cécile Coudy-Gandilhon
Autophagy Reports, 2022, 1 (1), pp.119-142. ⟨10.1080/27694127.2022.2049045⟩
Journal articles hal-03749953v1
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When idiopathic male infertility is rooted in maternal malnutrition during the perinatal period in mice

Yuki Muranishi , Laurent Parry , Mélanie Vachette-Dit-Martin , Fabrice Saez , Cécile Coudy-Gandilhon
Biology of Reproduction, 2022, 106 (3), pp.463-476. ⟨10.1093/biolre/ioab222⟩
Journal articles hal-03474813v1

Complex Mechanisms Link Dietary Sulfur Amino Acid Restriction to Health Improvement

Alain Bruhat , Isabelle Papet , Pierre Fafournoux
Journal of Nutrition, 2021, 151 (4), pp.749-750. ⟨10.1093/jn/nxaa457⟩
Journal articles hal-03373774v1
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HIF-1α triggers ER stress and CHOP-mediated apoptosis in alveolar epithelial cells, a key event in pulmonary fibrosis

Eva Delbrel , Abdoulaye Soumare , Adnan Naguez , Rabab Label , Olivier Bernard
Scientific Reports, 2018, 8 (1), pp.17939. ⟨10.1038/s41598-018-36063-2⟩
Journal articles hal-01974137v1
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Activation of cell surface GRP78 decreases endoplasmic reticulum stress and neuronal death

Morgane D Louessard , Isabelle D Bardou , Eloïse D Lemarchand , Audrey D Thiebaut , Jérôme D Parcq
Cell Death and Differentiation, 2017, 24 (9), pp.1518-1529. ⟨10.1038/cdd.2017.35⟩
Journal articles inserm-01586769v1
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Decreased ATF4 expression as a mechanism of acquired resistance to long-term amino acid limitation in cancer cells

Florent Mesclon , Sarah Lambert-Langlais , Valerie Carraro , Laurent Parry , Isabelle Hainault
Oncotarget, 2017, 8 (16), pp.27440-27453. ⟨10.18632/oncotarget.15828⟩
Journal articles hal-01594828v1

The CCAAT/enhancer-binding protein–ATF response elements-luciferase mouse model, an innovative tool to monitor the integrated stress response pathway in vivo

Alain Bruhat , Pierre Fafournoux
Current Opinion in Clinical Nutrition and Metabolic Care, 2017, 20 (3), pp.175-180. ⟨10.1097/MCO.0000000000000359⟩
Journal articles hal-01595543v1

Réguler l’expression d’un transgène thérapeutique par un régime alimentaire carencé en un acide aminé indispensable. Tuning transgene expression with an artificial diet: a compelling resource in gene therapy.

Alain Bruhat , Cedric Chaveroux , Valerie Carraro , Céline Jousse , Julien Averous
Médecine/Sciences, 2017, 33 (2), pp.136-139. ⟨10.1051/medsci/20173302007⟩
Journal articles hal-01595228v1
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Nutrient shortage triggers the hexosamine biosynthetic pathway via the GCN2-ATF4 signalling pathway

Cédric Chaveroux , Carmen Sarcinelli , Virginie Barbet , Sofiane Belfeki , Audray Barthelaix
Scientific Reports, 2016, 6 (1), ⟨10.1038/srep27278⟩
Journal articles hal-01595359v1
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Activation of the EIF2AK4-EIF2A/eIF2 alpha-ATF4 pathway triggers autophagy response to crohn disease-associated adherent-invasive escherichia coli infection

Alexis Bretin , Jessica Carrière , Guillaume Dalmasso , Agnes Bergougnoux , Wafa B'Chir
Autophagy, 2016, 12 (5), pp.770-783. ⟨10.1080/15548627.2016.1156823⟩
Journal articles hal-02640052v1
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GCN2 contributes to mTORC1 inhibition by leucine deprivation through an ATF4 independent mechanism

Julien Averous , Sarah Lambert-Langlais , Florent Mesclon , Valerie Carraro , Laurent Parry
Scientific Reports, 2016, 6 (1), pp.27698. ⟨10.1038/srep27698⟩
Journal articles hal-01438154v1

Regulating the expression of therapeutic transgenes by controlled intake of dietary essential amino acids

Cedric Chaveroux , Alain Bruhat , Valerie Carraro , Céline Jousse , Julien Averous
Nature Biotechnology, 2016, 34, pp.746-751. ⟨10.1038/nbt.3582⟩
Journal articles hal-01594469v1

Method for collecting mouse milk without exogenous oxytocin stimulation

Yuki Muranishi , Laurent Parry , Julien Averous , Anne Terrisse , Anne-Catherine Maurin
Biotechniques, 2016, 60 (1), pp.47-49. ⟨10.2144/000114373⟩
Journal articles hal-01274509v1

Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition)

Daniel Klionsky , Kotb Abdelmohsen , Akihisa Abe , Md Joynal Abedin , Hagai Abeliovich
Autophagy, 2016, 12 (1), pp.1-222. ⟨10.1080/15548627.2015.1100356⟩
Journal articles hal-03714337v1

In vivo imaging of the spatiotemporal activity of the eIF2 -ATF4 signaling pathway: Insights into stress and related disorders

C. Chaveroux , V. Carraro , L. Canaple , Julien Averous , Anne-Catherine Maurin
Science Signaling, 2015, 8 (374), pp.rs5-rs5. ⟨10.1126/scisignal.aaa0549⟩
Journal articles hal-02459218v1

Adaptation to the availability of essential amino-acids: role of GCN2/eIF2α/ATF4 pathway

Pierre Fafournoux , Julien Averous , Alain Bruhat , Valerie Carraro , Céline Jousse
Biologie Aujourd'hui, 2015, 209 (4), pp.317-23. ⟨10.1051/jbio/2016005⟩
Journal articles hal-01519158v1

L’activation de la voie eIF2α-ATF4, une réponse adaptative au stress cellulaire

Alain Bruhat , Céline Jousse , Valerie Carraro , Anne-Catherine Maurin , Cedric Chaveroux
Médecine/Sciences, 2015, 31 (12), pp.1057-1060. ⟨10.1051/medsci/20153112002⟩
Journal articles hal-01595102v1

Dual role for CHOP in the crosstalk between autophagy and apoptosis to determine cell fate in response to amino acid deprivation

Wafa B'Chir , Cedric Chaveroux , Valerie Carraro , Julien Averous , Anne-Catherine Maurin
Cellular Signalling, 2014, 26 (7), pp.1385 - 1391. ⟨10.1016/j.cellsig.2014.03.009⟩
Journal articles hal-02638190v1
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Perinatal Protein Malnutrition Affects Mitochondrial Function in Adult and Results in a Resistance to High Fat Diet-Induced Obesity

Céline Jousse , Yuki Muranishi , Laurent Parry , Christophe Montaurier , Patrick Even
PLoS ONE, 2014, 9 (8), pp.e104896. ⟨10.1371/journal.pone.0104896⟩
Journal articles hal-01365546v1

Requirement for lysosomal localization of mTOR for its activation differs between leucine and other amino acids

Julien Averous , Sarah Lambert-Langlais , Valerie Carraro , Ophélie Gourbeyre , Laurent Parry
Cellular Signalling, 2014, 26 (9), pp.1918-1927. ⟨10.1016/j.cellsig.2014.04.019⟩
Journal articles hal-02631139v1
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Hypothalamic eIF2 alpha signaling regulates food intake

Anne-Catherine Maurin , Alexandre Benani , Anne Lorsignol , Xavier Brenachot , Laurent Parry
Cell Reports, 2014, 6 (3), pp.438-444. ⟨10.1016/j.celrep.2014.01.006⟩
Journal articles hal-02635326v1
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The eIF2 alpha/ATF4 pathway is essential for stress-induced autophagy gene expression

Wafa B'Chir , Anne-Catherine Maurin , Valerie Carraro , Julien Averous , Céline Jousse
Nucleic Acids Research, 2013, 41 (16), pp.7683 - 7699. ⟨10.1093/nar/gkt563⟩
Journal articles hal-01056786v1

The amino acid sensor GCN2 biases macronutrient selection during aging

Anne-Catherine Maurin , Cedric Chaveroux , Sarah Langlais , Valerie Carraro , Céline Jousse
European Journal of Nutrition, 2012, 51 (1), pp.119 - 126. ⟨10.1007/s00394-011-0205-4⟩
Journal articles hal-02645818v1
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Translation termination efficiency modulates ATF4 response by regulating ATF4 mRNA translation at 5' short ORFs

Hayet Ait Ghezala , Béatrice Jolles , Samia Salhi , Katia Castrillo , Wassila Carpentier
Nucleic Acids Research, 2012, 40 (19), pp.9557 - 9570. ⟨10.1093/nar/gks762⟩
Journal articles hal-01544180v1

Perinatal undernutrition affects the methylation and expression of the leptin gene in adults: implication for the understanding of metabolic syndrome

Céline Jousse , Laurent Parry , Sarah Lambert‐langlais , Anne-Catherine Maurin , Julien Averous
FASEB Journal, 2011, 25 (9), pp.3271-3278. ⟨10.1096/fj.11-181792⟩
Journal articles hal-02460410v1

Amino acid deprivation regulates the stress-inducible gene p8 via the GCN2/ATF4 pathway

Julien Averous , S. Lambert-Langlais , Y. Cherasse , Valerie Carraro , Laurent Parry
Biochemical and Biophysical Research Communications, 2011, 413 (1), pp.24 - 29. ⟨10.1016/j.bbrc.2011.08.028⟩
Journal articles hal-02650318v1

Identification of GCN2 as new redox regulator for oxidative stress prevention in vivo

Cedric Chaveroux , Sarah Lambert-Langlais , Laurent Parry , Valerie Carraro , Céline Jousse
Biochemical and Biophysical Research Communications, 2011, 415 (1), pp.120 - 124. ⟨10.1016/j.bbrc.2011.10.027⟩
Journal articles hal-02645943v1
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Amino Acid Availability Controls TRB3 Transcription in Liver through the GCN2/eIF2 alpha/ATF4 Pathway

Valerie Carraro , Anne-Catherine Maurin , Sarah Lambert-Langlais , Julien Averous , Cedric Chaveroux
PLoS ONE, 2010, 5 (12), ⟨10.1371/journal.pone.0015716⟩
Journal articles hal-02660079v1

Amino acid limitation regulates the expression of genes involved in several specific biological processes through GCN2-dependent and GCN2-independent pathways

Christiane Deval , Cédric Chaveroux , Anne-Catherine Maurin , Yoan Cherasse , Laurent Parry
FEBS Journal, 2009, 276 (3), pp.707-718. ⟨10.1111/j.1742-4658.2008.06818.x⟩
Journal articles hal-02666432v1

Specificity of amino acid regulated gene expression: Analysis of genes subjected to either complete or single amino acid deprivation

Stella Palii , C.E. Kays , Christiane Deval , Alain Bruhat , Pierre Fafournoux
Amino Acids, 2009, 37 (1), pp.79-88. ⟨10.1007/s00726-008-0199-2⟩
Journal articles hal-02667613v1

Amino acids as regulators of gene expression in mammals: Molecular mechanisms

Alain Bruhat , Yoan Chérasse , Cédric Chaveroux , Anne-Catherine Maurin , Céline Jousse
Prostaglandins, Leukotrienes and Essential Fatty Acids, 2009, 35 (3), pp.249-257. ⟨10.1002/biof.40⟩
Journal articles hal-02664128v1

Amino-acid limitation induces the GCN2 signaling pathway in myoblasts but not in myotubes

Christiane Deval , Jeremie Talvas , Cédric Chaveroux , Anne-Catherine Maurin , Sylvie Mordier
Biochimie, 2008, 90 (11-12), pp.1716-1721. ⟨10.1016/j.biochi.2008.07.004⟩
Journal articles hal-02665914v1

Role of the repressor JDP2 in the amino acid-regulated transcription of CHOP

Yoan Cherasse , Cédric Chaveroux , Céline Jousse , Anne-Catherine Maurin , Valerie Carraro
FEBS Letters, 2008, 582 (10), pp.1537-1541. ⟨10.1016/j.febslet.2008.03.050⟩
Journal articles hal-02656794v1
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The p300/CBP-associated factor (PCAF) is a cofactor of ATF4 for amino acid-regulated transcription of CHOP

Yoan Cherasse , Anne-Catherine Maurin , Cédric Chaveroux , Céline Jousse , Valerie Carraro
Nucleic Acids Research, 2007, 35 (17), pp.5954-5965. ⟨10.1093/nar/gkm642⟩
Journal articles hal-02658408v1
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ATF2 is required for amino acid-regulated transcription by orchestrating specific histone acetylation

Alain Bruhat , Yoan Cherasse , Anne-Catherine Maurin , Wolfgang Breitwieser , Laurent Parry
Nucleic Acids Research, 2007, 35 (4), pp.1312-1321. ⟨10.1093/nar/gkm038⟩
Journal articles hal-02658676v1
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TRB3 inhibits the transcriptional activation of stress-regulated genes by a negative feedback on the ATF4 pathway

Céline Jousse , Christiane Deval , Anne-Catherine Maurin , Laurent Parry , Yoan Cherasse
Journal of Biological Chemistry, 2007, 282 (21), pp.15851-15861. ⟨10.1074/jbc.M611723200⟩
Journal articles hal-02663945v1

La kinase GCN2 régule le comportement alimentaire des omnivores afin de maintenir l’homéostasie des acides aminés

Anne-Catherine Maurin , Céline Jousse , Michelle M. Balage , Julien Averous , Laurent Parry
Médecine/Sciences, 2005, 21 (10), pp.799-801
Journal articles hal-02681321v1

The GCN2 kinase biases feeding behavior to maintain amino acid homeostasis in omnivores

Anne-Catherine Maurin , Celine Jousse , Julien Averous , Laurent Parry , Alain Bruhat
Cell Metabolism, 2005, 1 (4), pp.273-277. ⟨10.1016/j.cmet.2005.03.004⟩
Journal articles hal-02454718v1

Induction of IGFBP-1 expression by amino acid deprivation of HepG2 human hepatoma cells involves both a transcriptional activation and an mRNA stabilization due to its 3'UTR

Julien Averous , Anne-Catherine Maurin , Alain Bruhat , Céline Jousse , Celine Arliguie
FEBS Letters, 2005, 579 (12), pp.2609-2614. ⟨10.1016/j.febslet.2005.03.077⟩
Journal articles hal-02682908v1

Amino acids as regulators of gene expression : Molecular mechanisms

Céline Jousse , Julien Averous , Alain Bruhat , Valérie Carraro , Sylvie Mordier
Biochemical and Biophysical Research Communications, 2004, 313 (2), pp.447-452
Journal articles hal-02679439v1
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Induction of CHOP expression by amino acid limitation requires both ATF4 expression and ATF2 phosphorylation

Julien Averous , Alain Bruhat , Valerie Carraro , Céline Jousse , Gerald Thiel
Journal of Biological Chemistry, 2004, 279 (7), pp.5288-5297. ⟨10.1074/jbc.M311862200⟩
Journal articles hal-02683570v1

Recent advances in the understanding of amino acid regulation of gene expression

Julien Averous , Alain Bruhat , Sylvie Mordier , Pierre Fafournoux
Journal of Nutrition, 2003, 133 (6S), pp.2040S-2045S
Journal articles hal-02673076v1

Leucine : A key amino acid in ageing-associated sarcopeniau?

Dominique Dardevet , I. Rieu , Pierre Fafournoux , Claire Sornet , Lydie Combaret
Nutrition Research Reviews, 2003, 16 (1), pp.61-70
Journal articles hal-02676366v1
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Differences in the molecular mechanisms involved in the transcriptional activation of the CHOP and asparagine synthetase genes in response to amino acid deprivation or activation of the unfolded protein response

Alain Bruhat , Julien Averous , Valerie Carraro , Can Zhong , Andreas M. Reimold
Journal of Biological Chemistry, 2002, 277 (50), pp.48107-48114. ⟨10.1074/jbc.M206149200⟩
Journal articles hal-02683499v1

Inhibition of CHOP translation by a peptide encoded by an open reading frame localized in the chop 5'UTR

Céline Jousse , Alain Bruhat
Nucleic Acids Research, 2001, 29 (21), pp.4341-4351. ⟨10.1093/nar/29.21.4341⟩
Journal articles hal-02940973v1

Amino acid regulation of gene expression

Pierre Fafournoux , Alain Bruhat , Céline Jousse
Biochemical Journal, 2000, 351, 12 p
Journal articles hal-02684190v1

Evidence for multiple signaling pathways in the regulation of gene expression by amino acids in human cell lines

Céline Jousse , Alain Bruhat , Marc Ferrara , Pierre Fafournoux
Journal of Nutrition, 2000, 130, pp.1555-1560
Journal articles hal-02691090v1

Amino Acids Control Mammalian Gene Transcription: Activating Transcription Factor 2 Is Essential for the Amino Acid Responsiveness of the CHOP Promoter

Alain Bruhat , Valérie Carraro , Andreas Reimold , Marc M. Ferrara , Pierre Fafournoux
Molecular and Cellular Biology, 2000, 20 (19), pp.7192-7204. ⟨10.1128/mcb.20.19.7192-7204.2000⟩
Journal articles hal-02941593v1

Evidence for Multiple Signaling Pathways in the Regulation of Gene Expression by Amino Acids in Human Cell Lines

Céline Jousse , Alain Bruhat , Marc Ferrara , Pierre Fafournoux
Journal of Nutrition, 2000, 130 (6), pp.1555-1560. ⟨10.1093/jn/130.6.1555⟩
Journal articles hal-02941622v1

Amino acid regulation of gene expression

Céline Jousse , Alain Bruhat , Pierre Fafournoux
Current Opinion in Clinical Nutrition and Metabolic Care, 1999, 2, pp.297-301
Journal articles hal-02684376v1

Amino acid limitation regulates gene expression

Alain Bruhat , Céline Jousse , Pierre Fafournoux
Proceedings of the Nutrition Society, 1999, 58, 8 p
Journal articles hal-02684379v1

Amino acid limitation regulates CHOP expression through a specific pathway independent of the unfolded protein response

Céline Jousse , Alain Bruhat , H.P. Harding , Marc Ferrara , D. Ron
FEBS Letters, 1999, 448, pp.211-216
Journal articles hal-02691123v1

Physiological concentration of amino acids regulates insulin-like-growth-factor-binding protein 1 expression

Céline Jousse , Alain Bruhat , Marc Ferrara , Pierre Fafournoux
Biochemical Journal, 1998, 334 (1), pp.147-153. ⟨10.1042/bj3340147⟩
Journal articles hal-02941605v1

Physiological concentration of amino acids regulates insulin-like-growth-factor-binding protein 1 expression

Céline Jousse , Alain Bruhat , Marc Ferrara , Pierre Fafournoux
Biochemical Journal, 1998, 334, pp.147-153
Journal articles hal-02695981v1
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Amino acid limitation induces expression of CHOP, a CCAAT/enhancer binding protein-related gene, at both transcriptional and post-transcriptional levels

Alain Bruhat , Céline Jousse , Xiao-Zhong Wang , David Ron , Marc M. Ferrara
Journal of Biological Chemistry, 1997, 272 (28), pp.17588-17593. ⟨10.1074/jbc.272.28.17588⟩
Journal articles hal-02695708v1

NUTRIREG-T cells: a nutrition-based regulatory system of transgene expression in human T cells.

A. Dougé , Alain Bruhat , P.O. Rouzaire
FITC-ACT Workshop, co-organized with Institut Carnot CALYM. Current topics in the field of adoptive cell thera-py., Jan 2023, Lyon, France
Conference papers hal-04214109v1

NUTRIREG-T cells: a nutrition-based regulatory system of transgene expression in human T cells

Aurore Dougé , Alain Bruhat , Paul Rouzaire
FITC-ACT Workshop, co-organized with Institut Carnot CALYM. Current topics in the field of adoptive cell therapy, Jan 2023, LYON, France
Conference papers hal-04844759v1

Temporal regulation of transgene expression controlled by amino acid availability in human T cells

Aurore Dougé , Alain Bruhat , Paul Rouzaire
Journée de l'École Doctorale (ED SVSAE),, ED SVSAE Clermont-Ferrand, Jun 2023, Clermont-Ferrand, France
Conference papers hal-04844772v1

Production contrôlée d’une protéine médicament pour le traitement des métastases hépatiques du cancer colorectal (technologie NUTRIREG)

Cyrielle Vituret , Audrey Faure , Fida Azar , Pierre Verrelle , Alain Bruhat
4èmes automnales du Groupe Cancer Clermont Auvergne, Nov 2023, Clermont-Ferrand, France
Conference papers hal-04744329v1

Expression contrôlée d’un gène thérapeutique dans les lymphocytes T : vers une utilisation en immunothérapie cellulaire

A. Dougé , P.O. Rouzaire , Alain Bruhat
3rd Automnales du groupe Cancer Clermont Auvergne, Nov 2022, Clermont-Fd, France
Conference papers hal-04214085v1

Traitement du cancer par production contrôlée de peptides cytotoxiques

Cyrielle Vituret , Audrey Faure , Fida Azar , Pierre Verrelle , Alain Bruhat
Assises régionales de nutrition & santé, Oct 2022, Clermont - Ferrand, France
Conference papers hal-04214097v1

New insights into the role of GCN2-eIF2alpha signaling in the regulation of autophagy

Anne-Catherine Maurin , Laurent Parry , Wafa B’chir , Valérie Carraro , Cécile Coudy-Gandilhon
SCWD 15th International Conference on Cachexia, Sarcopenia and Muscle Wasting 2022, Society on Sarcopenia, Cachexia and Wasting Disorders, Jun 2022, Lisbonne, Portugal
Conference papers hal-04040983v1

The GCN2 kinase activates early events of autophagy

Anne-Catherine Maurin , Wafa B'Chir , Laurent Parry , Valerie Carraro , Florent Mesclon
8. Proteasome & Autophagy, Institut National de Recherche Agronomique (INRA). UMR Unité de Nutrition Humaine (1019).; Centre de Recherche en Nutrition Humaine (CRNH). FRA., Apr 2018, Clermont-Ferrand, France. 90 p
Conference papers hal-01786043v1

Le sensing par GCN2 : la souris CARE-LUC, un outil pour visualiser l’activation de la voie GCN2-eIF2a-ATF4

Alain Bruhat
JFN 2018, Journées Francophones de Nutrition, Nov 2018, Nice, France
Conference papers hal-01937086v1
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Identification de marques épigénétiques marqueurs de prédisposition aux maladies métaboliques

Jérémy Tournayre , Laurent Parry , Anne-Catherine Maurin , Julien Averous , Alain Bruhat
JOBIM 2018 Journées Ouvertes Biologie, Informatique et Mathématiques, Jul 2018, Marseille, France
Conference papers hal-01930383v1

Mécanismes d’adaptation à la disponibilité en acides aminés indispensables : rôles de la voie GCN2/eIF2/ATF4

Pierre Fafournoux , Julien Averous , Alain Bruhat , Valerie Carraro , Céline Jousse
Société de Biologie, Société de Biologie. FRA., Dec 2015, Paris, France
Conference papers hal-02796515v1
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Identification des mécanismes moléculaires impliqués dans la résistance des cellules à une carence en acides aminés

Florent Mesclon , Sarah Langlais , Valerie Carraro , Laurent Parry , Cedric Chaveroux
2emes Assises Inter-Régionales De Nutrition et Métabolisme, Institut National de Recherche Agronomique (INRA). UMR Unité de Nutrition Humaine (1019).; Laboratoire de recherche en Cardiovasculaire, Métabolisme, Diabétologie et Nutrition (CarMeN). Lyon, FRA.; Université Joseph Fourier (Grenoble 1) (UJF). Grenoble, FRA.; Centre de Recherche en Nutrition Humaine (CRNH). FRA.; Centre de Recherche en Nutrition Humaine (CRNH). FRA., Nov 2015, Saint Galmier, France, France
Conference papers hal-01237880v1

Amino acid sensig: The EIF2A signaling in health and disease

Pierre Fafournoux , Julien Averous , Alain Bruhat , Valerie Carraro , Céline Jousse
1. Congress of Physiology and Integrative Biologie and 84. Congress of French Physiological Society (SFP), Société de Physiologie. Vieillevigne, FRA., May 2015, Strasbourg, France. 92 p., ⟨10.1111/apha.12520⟩
Conference papers hal-02742614v1

Hypothalamic eIF2 alpha signaling regulates food intake

Anne-Catherine Maurin , Alexandre Benani , Anne Lorsignol-Desmet , Xavier Brenachot , Laurent Parry
Assises du département Alimh, Jan 2014, Arêches, France. n.p
Conference papers hal-01065490v1

Régulation de l'expression des gènes par les acides aminés, aspects in vitro et in vivo

Céline Jousse , Julien Averous , Anne-Catherine Maurin , Yoan Cherasse , Christiane Deval
Journée Scientifique du CNRH D'Auvergne, Apr 2004, Theix, France
Conference papers hal-02760814v1

Les facteurs de transcription ATF2 et ATF4 sont impliqués dans la régulation du gène chop par la carence en acides aminés

Julien Averous , Alain Bruhat , Valérie Carraro , Céline Jousse , Pierre Fafournoux
5. Réunion, Jun 2003, Clermont-Ferrand, France
Conference papers hal-02763975v1

Recent advances in the understanding of amino acid regulation of gene expression

Julien Averous , Alain Bruhat , Sylvie Mordier , Pierre Fafournoux
2. Workshop on the Assessment of Adequate Intake of Dietary Amino Acids, Oct 2002, Honolulu, United States
Conference papers hal-02828538v1

Temporal regulation of transgene expression controlled by amino acid availability in human T cells

A. Dougé , P.O. Rouzaire , Alain Bruhat
Journée de l'École Doctorale (ED SVSAE), Jun 2023, Clermont-Ferrand, France
Conference poster hal-04214122v1

Regulating the expression of therapeutic transgenes by controlled intake of dietary essential amino acids: the Nutrireg technology platform

Cyrielle Vituret , Fida Azar , Audrey Faure , Valérie Carraro , Céline Jousse
European Society of Gene & Cell Therapy 30th Annual Congress, Oct 2023, Brussel, Belgium
Conference poster hal-04214142v1

Characterization of IL-6 and GDF15 expression during the transition from pre-anorexia to anorexia in the C26 tumor-bearing mouse model

Ghita Chaouki , Laurent Parry , Laure Bindels , Céline Jousse , Isabelle Papet
SCWD 15th International Conference on Cachexia, Sarcopenia and Muscle Wasting 2022, Jun 2022, Lisbonne, Portugal
Conference poster hal-04041599v1

Pretreatment with halofuginone attenuates adverse effects of acute inflammatory stress on mitochondrial alterations and mitophagy/biogenesis markers in liver

Ghita Chaouki , Laurent Parry , Isabelle Papet , Céline Jousse , Etienne Lefai
9th proteasome and autophagy congress, 2021, Oct 2021, Clermont-Ferrand, France
Conference poster hal-04845987v1

GCN2 contributes to mTORC1 inhibition by leucine deprivation through an ATF4 independent mechanism

Julien Averous , Sarah Lambert-Langlais , Florent Mesclon , Valerie Carraro , Laurent Parry
1.edition Target of Rapamycin science club in France, le "TOR de France", May 2018, Nice, France. 2018
Conference poster hal-01811435v1

Regulating the expression of therapeutic transgenes by controlled intake of dietary essential amino acids

Alain Bruhat , Pierre Fafournoux
ESGCT XXV Anniversary Congress, Oct 2017, Berlin, Germany. 2017, ⟨10.1038/nbt.3582⟩
Conference poster hal-02737715v1

Activation of the EIF2AK4-EIF2A/eIF2 alpha-ATF4 pathway triggers autophagy response to Crohn disease-associated adherent-invasive escherichia coli infection

Alexis Bretin , Jessica Carrière , Guillaume Dalmasso , Agnes Bergougnoux , Wafa B'Chir
7. Proteasomes and Autophagy Workshop, Apr 2016, clermont-ferrand, France. 320 p., 2016, 7th Proteasomes and Autophagy Workshop
Conference poster hal-02740425v1
Image document

The GCN2 kinase is required for activating autophagy in response to indispensable amino acid deficiencies

Anne-Catherine Maurin , Wafa B'Chir , Vanessa Reinhardt , Laurent Parry , Valerie Carraro
7. Proteasomes & Autophagy Workshop, Apr 2016, Clermont-Ferrand, France. 320 p., 2016, 7th Proteasomes & Autophagy Workshop
Conference poster hal-01305347v1

Activation of the GCN2/eIF2alpha/ATF4 signaling pathway triggers autophagy response to infection with Crohn's disease-associated adherent-invasive Escherichia coli

A. Bretin , J. Carrière , Marion Dalmasso , N. Barnich , A. Bergougnoux
10. Congress of ECCO. Inflammatory Bowel Diseases, Feb 2015, Barcelone, Spain. , Journal of Crohn's and Colitis, 9, 2015, 10th Congress of ECCO. Inflammatory Bowel Diseases
Conference poster hal-02740431v1

Identification of molecular mechanisms involved in cancer cell resistance to amino acid deprivation

Florent Mesclon , Sarah Langlais , Valerie Carraro , Laurent Parry , Cedric Chaveroux
Cancer and Metabolism conference, ABCAM 2015, Sep 2015, Cambridge, United Kingdom. , 2015
Conference poster hal-02739369v1
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Development and optimization of a new gene regulation system controlled by nutrition applicable for gene therapy

Cedric Chaveroux , Alain Bruhat , Valerie Carraro , Julien Averous , Céline Jousse
Congrès de la Société Française de Thérapie Cellulaire et Génique (SFTCG), Mar 2014, Toulouse, France. , 2014
Conference poster hal-02740006v1

Génération d’un modèle de souris transgénique pour visualiser en temps réel l’activation de la voie eIF2α/ATF4 lors d’un stress nutritionnel

Alain Bruhat , Cedric Chaveroux , Valerie Carraro , Julien Averous , Céline Jousse
Assises du Département Alimh, Jan 2014, Arêches, France. , 2014, Assises du Département Alimh
Conference poster hal-01190022v1
Image document

The GCN2/eIF2α/ATF4 signaling pathway is necessary for autophagy response to infection with Crohn’s disease-associated adherent-invasive Escherichia coli

Thuy Thi Thu Nguyen , Jessica Carrière , Guillaume Dalmasso , Anne-Catherine Maurin , Alain Bruhat
6. Journée scientifique du CNRH Auvergne, Nov 2013, Clermont - Ferrand, France. , 2013, 6ème Journée scientifique du CNRH Auvergne
Conference poster hal-02750413v1

The eIF2α/ATF4 pathway is essential for stress-induced autophagy gene expression

Wafa B'Chir , Anne-Catherine Maurin , Julien Averous , Céline Jousse , Yuki Muranishi
EMBO Conference, Autophagy: Molecular Mechanisms, Physiology and Pathology, May 2013, Hurtigruten, Norway. 2013
Conference poster hal-02748854v1