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Alexis Peaucelle



EDUCATION/TRAINING INSTITUTION AND LOCATION DEGREE *(if applicable)* Completion Date MM/YYYY FIELD OF STUDY Admission to Ecole Normale Supérieure de Lyon / *Université* Claude Bernard, *Lyon, France* Magister 06/2001 Biology Université Paris-Sud (Paris 11), Paris, France Masters (DEA) 06/2002 Cellular and molecular biology of plants Université Paris-Sud (Paris 11), Paris, France PhD 10/2006 plant physiology Laboratoire Matières et Systèmes Complexes, Université Denis Diderot (Paris 7), Paris, France Postdoctoral training 12/2007 Plant Biophysics Sainsbury Laboratory, Cambridge University, Cambridge, UK Université Paris-Sud (Paris 11), Paris, France Sabbatical « Habilitation à diriger des recherches » 01/2013-12/2014 10/2016 Leaf Morphogenesis Plant morphogenesis **A. Personal Statement** **I want to unravel the origin of the beauty and diversity of shapes observed in nature. To fulfill my goals I follow a multidisciplinary path combining genetics, biophysics and biochemistry. During my PhD, I explored the genetic and epigenetic patterning of apical tissues in plants. During my first post-doctoral training, I joined the biomechanics stronghold in France: The “**Laboratoire Matières et Systèmes” Complexes **at the** Université Paris Diderot **were I pioneered AFM based micro-mechanical measurements on living tissues (plant and animal tissues). In parallel, I started a long-standing collaboration with Herman Hôfte focused on the biochemistry of the plant extracellular matrix: the cell wall. Finally, during my sabbatical stay at the Sainsbury Laboratory at Cambridge University, I established a fruitful collaboration with Kalina T. Haas (MRC Cancer Unit, University of Cambridge). This led to the development of 3D dSTORM nanoscopy imaging of plant tissues. This combined with Finite Element Method (FEM) modeling led us to propose a new model for cell wall expansion, which consists of a paradigm shift in our understanding of plant growth. This opens a completely new landscape of possibilities and conceptual frameworks for the control of morphogenesis, which may also be applicable to other life forms.** **I also happily invest considerable time and effort in outreach and teaching activities. Finally, I am also interested in potential industrial applications of my research with the deposition of 2 patents.** **B. Positions and Honors** • **01/2020:** member of the first council of the Graduate School “Biosphera” at Université Paris Saclay • **01/2008- present:** INRAe Versailles, Chargé de Recherche (equivalent of Assistant Professor) in the Primary Cell Wall group at the «Institut JP Bourgin». • **01/2013-12/2014 Sainsbury Laboratory, Cambridge University** Sabbatical funded by “AgreenSkills” European Union (COFUND-FP7 People Programme) • **01/2008-12/2012 l’UFR Physique, Université Denis Diderot (Paris 7)** «Détaché» at the **«**Laboratoire Matières et Systèmes Complexes», Equipe «Systèmes Hors-Equilibre» **•** **01/2006-12/2007 l’UFR Physique, Université Denis Diderot (Paris 7)** Post-doctoral stage at the **«**Laboratoire Matières et Systèmes Complexes». Group leader: Yves COUDER **C. Additional Information: Research Support and/or Scholastic Performance** Patents: -« Un traitement phytosanitaire extrait de plante respectueux de l’environnement » EC -« Une foreuse hydraulique inspirée par la mécanique de la croissance racinaire » DI-RV-12-005 projects funded by competitive programmes: · ANR blanc “GoodVibration” (2018) Coordinator. The role of sound of growth stimulation in plants · ANR “Homeowall” (2020) Chemical feedback during growth. · Marie Curie AgreenSkills (2013) 3D mechanical imaging of leaf growth · ANR blanc « GrowPec » (2009) Pectin metabolism and control of growth in plants · ANR blanc « MechaStem » (2010) The physics of plant morphogenesis **·** Programme interdisciplinaire CNRS (2010) Morphogenesis in jellyfish, *Aurelia aurita* **D. Teaching** **From 2016** Sorbonne university: Physiques and face transition in food and food processes 90h/year **2020. University of Milano** Invited lecturer 4 hours. **2013-2015. Université de Cambridge** 48h/year biochimie **2013-2014. Université de Cambridge.** 8h hours Tutorial in génétiques, **2006-2013. UVSQ.** 228 h/year Plant biology **2006-2008. UVSQ.** 6 hours Statistiques **2003-2006. UVSQ.** 64 h/year Plant philologie **E. outreach** **2022. Fête de la science.** Plant growth reaviled SPS Orsay **2022. Plantes et société** Labbe visites for kids to surdents IJPB **2020. On ligne Fête de la science.** SPS Orsay **2019. Fascination of *Plants Day.*** *SPS Orsay* **2018. Salon de l’agriculture.** Plants genetics: phenotyping **2014. Fascination of *Plants Day.* Cambridge botanic garden. **2013. Fascination of *Plants Day.*** *Cambridge botanic garden.* **2013. SLCU participation in Newnham College’s residential course**. **2012. Fête de la science.** Supraconductivity **2012. Festival de sciences Paris-Montagne**. Scientific Referent **2010. Fête de la science.** What is biophysic and development **2008. Workshop on GMO in school** (Lycée de Jouy-le-Moutier, 95) **2008. Fête de la science.** Wonders of phyllotaxis **2007. Fête de la science.** Good and bad biofuels **2007. Salon de l’agriculture.** Good and bad biofuels **2004. Workshop on GMO in school** (collège de Gomes, 93) **2000. Fête de la science.** The 5 senses **F. patents** \*Un traitement phytosanitaire extré de plante respectueuse de l’environnement EC \*Une foreuse hydraulique inspirée par la mécanique de la croissance racinaire DI-RV-12-0054


A cell wall-associated gene network shapes leaf boundary domains

Nathalie Boure , Alexis Peaucelle , Magali Goussot , Bernard Adroher , Ludivine Soubigou-Taconnat et al.
Development (Cambridge, England), 2022, 149 (11), pp.dev200359. ⟨10.1242/dev.200359⟩
Journal articles hal-03737566v1
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The role of pectin phase separation in plant cell wall assembly and growth

Kalina Haas , Raymond Wightman , Alexis Peaucelle , Herman Höfte
The Cell Surface, 2021, 7 (2), pp.100054. ⟨10.1016/j.tcsw.2021.100054⟩
Journal articles hal-03767940v1

The role of pectin phase separation in plant cell wall assembly and growth

Kalina Haas , Raymond Wightman , Alexis Peaucelle , Herman Höfte
The Cell Surface, 2021, 7, pp.100054. ⟨10.1016/j.tcsw.2021.100054⟩
Journal articles hal-03767965v1
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From monocots to dicots: the multifold aspect of cell wall expansion

Kalina T Haas , Alexis Peaucelle
Journal of Experimental Botany, 2021, 72 (5), pp.1511-1513. ⟨10.1093/jxb/eraa573⟩
Journal articles hal-03331832v1
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Second order division in sectors as a prepattern for sensory organs in vertebrate development

Vincent Fleury , Alexis Peaucelle , Anick Abourachid , Olivia Plateau
Theorie in den Biowissenschaften / Theory in Biosciences, 2021, ⟨10.1007/s12064-021-00350-w⟩
Journal articles hal-03098723v2

Protocol for multicolor three-dimensional dSTORM data analysis using MATLAB-based script package Grafeo

Kalina Tamara Haas , Alexis Peaucelle
STAR Protocols, 2021, 2 (3), pp.100808. ⟨10.1016/j.xpro.2021.100808⟩
Journal articles hal-03767947v1
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A blueprint of the topology and mechanics of the human ovary for next-generation bioengineering and diagnosis

Emna Ouni , Alexis Peaucelle , Kalina Haas , Olivier van Kerk , Marie-Madeleine Dolmans et al.
Nature Communications, 2021, 12 (1), pp.5603. ⟨10.1038/s41467-021-25934-4⟩
Journal articles hal-03767951v1

Multicolor 3D-dSTORM Reveals Native-State Ultrastructure of Polysaccharides' Network during Plant Cell Wall Assembly

Alexis Peaucelle , Raymond Wightman , Kalina Tamara Haas
iScience, 2020, 23 (12), pp.101862. ⟨10.1016/j.isci.2020.101862⟩
Journal articles hal-03155899v1

Pectin homogalacturonan nanofilament expansion drives morphogenesis in plant epidermal cells

Kalina T Haas , Raymond Wightman , Elliot Meyerowitz , Alexis Peaucelle
Science, 2020, 367 (6481), pp.1003-1007. ⟨10.1126/science.aaz5103⟩
Journal articles hal-02936700v1

ELIMÄKI Locus Is Required for Vertical Proprioceptive Response in Birch Trees

Graphical Abstract , Juan Alonso-Serra , Xueping Shi , Alexis Peaucelle , Pasi Rastas et al.
Current Biology - CB, 2020, 30 (4), pp.589-599.e5. ⟨10.1016/j.cub.2019.12.016⟩
Journal articles hal-02936730v1

Exploring the relation between apical growth, organ formation and cell wall mechanics across land plant species

Alexis Peaucelle
Comptes Rendus Mécanique, 2020, 348 (6-7), pp.685-692. ⟨10.5802/crmeca.28⟩
Journal articles hal-03160358v1

Multitarget Immunohistochemistry for Confocal and Super-resolution Imaging of Plant Cell Wall Polysaccharides

Kalina Haas , Methieu Rivière , Raymond Wightman , Alexis Peaucelle
Bio-protocol , 2020, 10 (19), ⟨10.21769/BioProtoc.3783⟩
Journal articles hal-03155987v1
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Exploring the relation between apical growth, organ formation and cell wall mechanics across land plant species

Alexis Peaucelle
Comptes Rendus Mécanique, 2020, ⟨10.5802/crmeca.28>⟩
Journal articles hal-03769001v1

The hook shape of growing leaves results from an active regulatory process

Mathieu Rivière , Yoann Corre , Alexis Peaucelle , Julien Derr , Stéphane Douady et al.
Journal of Experimental Botany, 2020, 71 (20), pp.6408-6417. ⟨10.1093/jxb/eraa378⟩
Journal articles hal-03155956v1
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Wolpert's French Flag: what's the problem?

Alexis Peaucelle , James Sharpe
Development (Cambridge, England), 2019, 146 (24), pp.dev185967. ⟨10.1242/dev.185967⟩
Journal articles hal-02936707v1

Primary wall cellulose synthase regulates shoot apical meristem mechanics and growth

Arun Sampathkumar , Alexis Peaucelle , Miki Fujita , Christoph Schuster , Staffan Persson et al.
Development (Cambridge, England), 2019, 146 (10), pp.1-11. ⟨10.1242/dev.179036⟩
Journal articles hal-02627296v1
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The FERONIA receptor kinase maintains cell-wall integrity during salt stress through Ca2+ signaling

Wei Feng , Daniel Kita , Alexis Peaucelle , Heather N. Cartwright , Vinh Doan et al.
Current Biology - CB, 2018, 28 (5), pp.666-675 ; e1-e5. ⟨10.1016/j.cub.2018.01.023⟩
Journal articles hal-02625236v1

Non-invasive Protocol for Kinematic Monitoring of Root Growth under Infrared Light

François Bizet , Lionel Dupuy , Anthony Glyn Bengough , Alexis Peaucelle , Irène Hummel et al.
Bio-protocol , 2017, 7 (14), ⟨10.21769/BioProtoc.2390⟩
Journal articles hal-03145724v1

Physics of amniote formation

Ameya Vaishnavi Murukutla , Vincent Fleury , Ameya Vaishnavi Murukutla , Nicolas Chevalier , Benjamin Gallois et al.
Physical Review E , 2016, 94 (2), ⟨10.1103/PhysRevE.94.022426⟩
Journal articles hal-02936720v1

Regulation of Meristem Morphogenesis by Cell Wall Synthases in Arabidopsis

Weibing Yang , Christoph Schuster , Cherie T. Beahan , Varodom Charoensawan , Alexis Peaucelle et al.
Current Biology - CB, 2016, 26 (11), pp.1404-1415. ⟨10.1016/j.cub.2016.04.026⟩
Journal articles hal-01531680v1

KymoRod: a method for automated kinematic analysis of rod-shaped plant organs

Renaud Bastien , David Legland , Marjolaine Martin , Lucien Fregosi , Alexis Peaucelle et al.
Plant Journal, 2016, 88 (3), pp.468-475. ⟨10.1111/tpj.13255⟩
Journal articles hal-01417736v1
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Fibonacci spirals in a brown alga [Sargassum muticum (Yendo) Fensholt] and in a land plant [Arabidopsis thaliana (L.) Heynh.]: a case of morphogenetic convergence

Alexis Peaucelle , Yves Couder
Acta Societatis Botanicorum Poloniae, 2016, 85 (4), ⟨10.5586/asbp.3526⟩
Journal articles hal-01604348v1

The Control of Growth Symmetry Breaking in the Arabidopsis Hypocotyl

Alexis Peaucelle , R. Wightman , Hermanus Höfte
Current Biology - CB, 2015, 25 (13), ⟨10.1016/j.cub.2015.05.022⟩
Journal articles hal-01204193v1

AFM-based mapping of the elastic properties of cell walls: at tissue, cellular, and subcellular resolutions

Alexis Peaucelle
Journal of visualized experiments : JoVE, 2014, 89, ⟨10.3791/51317⟩
Journal articles hal-01204113v1

Mechanical control of morphogenesis at the shoot apex

Sarah Robinson , Agata Burian , Etienne Couturier , Benoit Landrein , Marion Louveaux et al.
Journal of Experimental Botany, 2013, 64 (15), pp.4729-4744. ⟨10.1093/jxb/ert199⟩
Journal articles hal-01204009v1
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Mechano-chemical aspects of organ formation in [i]Arabidopsis thaliana[/i]: the relationship between auxin and pectin

Siobhan A. S. A. Braybrook , Alexis A. Peaucelle
PLoS ONE, 2013, 8 (3), 10 p. ⟨10.1371/journal.pone.0057813⟩
Journal articles hal-01004470v1
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Cell wall mechanics and growth control in plants: the role of pectins revisited

Alexis Peaucelle , Siobhan A. Braybrook , Hermanus Höfte
Frontiers in Plant Science, 2012, 3, pp.1-6. ⟨10.3389/fpls.2012.00121⟩
Journal articles hal-01203961v1

Probing the mechanical contributions of the pectin matrix: Insights for cell growth

Siobhan A. Braybrook , Hermanus Höfte , Alexis Peaucelle
Plant Signaling and Behavior, 2012, 7 (8), pp.1037-1041. ⟨10.4161/psb.20768⟩
Journal articles hal-01203966v1

Mechanical Stress Acts via Katanin to Amplify Differences in Growth Rate between Adjacent Cells in Arabidopsis

Magalie M. Uyttewaal , Agata A. Burian , Karen K. Alim , Benoi T. B. T. Landrein , Dorota D. Borowska-Wykret et al.
Cell, 2012, 149 (2), pp.439 - 451. ⟨10.1016/j.cell.2012.02.048⟩
Journal articles hal-01004210v1

Pectin-Induced Changes in Cell Wall Mechanics Underlie Organ Initiationin Arabidopsis

Alexis A. Peaucelle , Siobhan A. S. A. Braybrook , Laurent L. Le Guillou , Emeric E. Bron , Cris C. Kuhlemeier et al.
Current Biology - CB, 2011, 21 (20), pp.1720 - 1726. ⟨10.1016/j.cub.2011.08.057⟩
Journal articles hal-01004590v1
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The transcription factor BELLRINGER modulates phyllotaxis by regulating the expression of a pectin methylesterase in Arabidopsis

Alexis A. Peaucelle , Romain R. Louvet , Jorunn Nergaard J. N. Johansen , Fabien F. Salsac , Halima H. Morin et al.
Development (Cambridge, England), 2011, 138 (21), pp.4733 - 4741. ⟨10.1242/dev.072496⟩
Journal articles hal-01000628v1

Shaping the meristem by mechanical forces

Patrick Laufs , Alexis Peaucelle , Herman Höfte
F1000 Biology Reports, 2009, 1 (45), pp.1-4. ⟨10.3410/B1-45⟩
Journal articles hal-02657714v1

Interplay of miR164, CUP-SHAPED COTYLEDON genes and LATERAL SUPPRESSOR controls axillary meristem formation in Arabidopsis thaliana

Smita Raman , Thomas Greb , Alexis Peaucelle , Thomas Blein , Patrick Laufs et al.
Plant Journal, 2008, 55 (1), pp.65-76. ⟨10.1111/j.1365-313X.2008.03483.x⟩
Journal articles hal-01604969v1

Arabidopsis phyllotaxis is controlled by the methyl-esterification status of cell-wall pectins

Alexis Peaucelle , Romain R. Louvet , Jorunn Nergaard J. N. Johansen , Herman Höfte , Patrick Laufs et al.
Current Biology - CB, 2008, 18 (24), pp.1943-1948. ⟨10.1016/j.cub.2008.10.065⟩
Journal articles hal-02663627v1

Phyllotaxy: Beyond the Meristem and Auxin Comes the miRNA

Alexis Peaucelle , Patrick Laufs
Plant Signaling and Behavior, 2007, 2 (4), pp.293-295. ⟨10.4161/psb.2.4.4040⟩
Journal articles hal-02657740v1

Plant expressing a miR164-resistant CUC2 gene reveal the importance of post-meristematic maintenance of phyllotaxy in Arabidopsis

Alexis Peaucelle , Jan Traas , H. Morin , Patrick Laufs
Development (Cambridge, England), 2007, 134 (6), pp.1045-1050
Journal articles hal-00412573v1

Plants expressing a miR164-resistant CUC2 gene reveal the importance of post-meristematic maintenance of phyllotaxy in Arabidopsis

Alexis A. Peaucelle , Halima H. Morin , Jan Traas , Patrick P. Laufs
Development (Cambridge, England), 2007, 134, pp.1045-1050. ⟨10.1242/dev.02774⟩
Journal articles hal-02658060v1

Cell differentiation and organ initiation at the shoot apical meristem

Nicola Carraro , Alexis A. Peaucelle , Patrick P. Laufs , Jan Traas
Plant Molecular Biology, 2006, 60 (6), pp.811-826. ⟨10.1007/s11103-005-2761-6⟩
Journal articles hal-02660108v1

The balance between the MIR164A and CUC2 genes controls leaf margin serration in Arabidopsis

Krisztina Nikovics , Thomas T. Blein , Alexis A. Peaucelle , Tetsuya Ishida , Halima H. Morin et al.
The Plant cell, 2006, 18 (11), pp.2929-2945
Journal articles hal-02669130v1

The UN peace-keeping force in the plants: a microRNA, miR164, stabilizes the boundary domain in the meristern

Alexis A. Peaucelle , Patrick P. Laufs
médecine/sciences, 2006, 22 (10), pp.796-798
Journal articles hal-02653606v1
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MicroRNA regulation of the CUC genes is required for boundary size control in Arabidopsis meristems

Patrick Laufs , Alexis Peaucelle , Halima Morin , Jan Traas
Development (Cambridge, England), 2004, 131 (17), pp.4311-4322. ⟨10.1242/dev.01320⟩
Journal articles hal-02680346v1

The ethanol switch: a tool for tissue-specific gene induction during plant development

Yves Deveaux , Alexis Peaucelle , Gethin R Roberts , Enrico Coen , Rüdiger Simon et al.
Plant Journal, 2003, 36 (6), pp.918-930. ⟨10.1046/j.1365-313X.2003.01922.x⟩
Journal articles hal-02680631v1