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ID Card of Mcl-1 PROTAC degrader: From in silico design to biological validation in chemoresistant ovarian cancer
Marie Cornu
,
Jocelyn Pezeril
,
Nicolas Guedeney
,
Hippolyte Paysant
,
Thomas Lemaitre
et al.
Article dans une revue
hal-05583537v1
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PROTAC 2.0: Expanding the frontiers of targeted protein degradation
Marie Cornu
,
Thomas Lemaitre
,
Charline Kieffer
,
Anne Sophie Voisin-Chiret
Article dans une revue
hal-05472074v1
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Synthesis and biological studies on ovarian cancer cells of new heterocyclic molecules inspired by MIM1, an inhibitor of the anti-apoptotic protein Mcl-1
Jocelyn Pezeril
,
Louis-Bastien Weiswald
,
Ali Soulieman
,
Hippolyte Paysant
,
Ali Hachem
et al.
Article dans une revue
hal-05245395v1
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UBE2N: Hope on the Cancer Front, How to Inhibit This Promising Target Prospect?
Florian Schwalen
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Côme Ghadi
,
Léonie Ibazizene
,
Shafi Ullah Khan
,
Jana Sopkova-de Oliveira Santos
et al.
Article dans une revue
hal-04885402v1
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PROTAC : Nouvelles stratégies thérapeutiques basées sur l’exploitation des voies de dégradation des protéines
Marie Cornu
,
Thomas Lemaitre
,
Florian Schwalen
,
Charline Kieffer
,
Anne Sophie Voisin-Chiret
Article dans une revue
istex
hal-05583533v1
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PROTAC 2.0: Expanding the frontiers of targeted protein degradation
Marie Cornu
,
Thomas Lemaitre
,
Charline Kieffer
,
Anne Sophie Voisin-Chiret
Article dans une revue
hal-05583536v1
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Molecular glue degraders: exciting opportunities for novel drug discovery
Thomas Lemaitre
,
Marie Cornu
,
Florian Schwalen
,
Marc Since
,
Charline Kieffer
et al.
Article dans une revue
hal-04711906v1
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Disruption of PHF6 Peptide Aggregation from Tau Protein: Mechanisms of Palmatine Chloride in Preventing Early PHF6 Aggregation
Charline Fagnen
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Johanna Giovannini
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Thomas Vignol
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Marc Since
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Marco Catto
et al.
Article dans une revue
hal-04847910v1
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Towards New Anti‐inflammatory Agents: Design, Synthesis and Evaluation of Molecules Targeting XIAP‐BIR2
Marc Ragui Farag
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Nicolas Guedeney
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Florian Schwalen
,
Aymeric Zadorovnyj
,
Amelie Barczyk
et al.
Article dans une revue
hal-04772005v1
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Towards New Anti‐Inflammatory Agents: Design, Synthesis and Evaluation of Molecules Targeting XIAP‐BIR2
Marc Farag
,
Nicolas Guedeney
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Florian Schwalen
,
Aymeric Zadoroznyj
,
Amélie Barczyk
et al.
Article dans une revue
hal-05583526v1
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Molecular glue degraders: exciting opportunities for novel drug discovery
Thomas Lemaitre
,
Marie Cornu
,
Florian Schwalen
,
Marc Since
,
Charline Kieffer
et al.
Article dans une revue
hal-05583519v1
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PROTAC technology: A new drug design for chemical biology with many challenges in drug discovery
Nicolas Guedeney
,
Marie Cornu
,
Florian Schwalen
,
Charline Kieffer
,
Anne Sophie Voisin-Chiret
Article dans une revue
hal-05583541v1
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Computational Tool to Design Small Synthetic Inhibitors Selective for XIAP-BIR3 Domain
Marc Farag
,
Charline Kieffer
,
Nicolas Guedeney
,
Anne Sophie Voisin-Chiret
,
Jana Sopkova-de Oliveira Santos
Article dans une revue
hal-04222485v1
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Synthesis of oxetane and azetidine ethers as ester isosteres by Brønsted acid catalysed alkylation of alcohols with 3-aryl-oxetanols and 3-aryl-azetidinols
Peerawat Saejong
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Juan Rojas
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Camille Denis
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Andrew White
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Anne Sophie Voisin-Chiret
et al.
Article dans une revue
hal-04222509v1
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PROTAC technology: A new drug design for chemical biology with many challenges in drug discovery
Nicolas Guedeney
,
Marie Cornu
,
Florian Schwalen
,
Charline Kieffer
,
Anne Sophie Voisin-Chiret
Article dans une revue
hal-03936766v1
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Computational Tool to Design Small Synthetic Inhibitors Selective for XIAP-BIR3 Domain
Marc Farag
,
Charline Kieffer
,
Nicolas Guedeney
,
Anne Sophie
,
Jana Sopkova-de Oliveira Santos
Article dans une revue
hal-04148037v1
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On the Tracks of the Aggregation Mechanism of the PHF6 Peptide from Tau Protein: Molecular Dynamics, Energy, and Interaction Network Investigations
Charline Fagnen
,
Johanna Giovannini
,
Marco Catto
,
Anne Sophie Voisin-Chiret
,
Jana Sopkova-de Oliveira Santos
Article dans une revue
hal-03949234v1
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Tau protein aggregation: Key features to improve drug discovery screening
Johanna Giovannini
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Willy Smeralda
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Marie Jouanne
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Jana Sopkova-de Oliveira Santos
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Marco Catto
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Article dans une revue
hal-04847953v1
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Estrogen Receptor-α Targeting: PROTACs, SNIPERs, Peptide-PROTACs, Antibody Conjugated PROTACs and SNIPERs
Arvind Negi
,
Kavindra Kumar Kesari
,
Anne Sophie Voisin-Chiret
Article dans une revue
hal-03936776v1
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Light-Activating PROTACs in Cancer: Chemical Design, Challenges, and Applications
Arvind Negi
,
Kavindra Kumar Kesari
,
Anne Sophie Voisin-Chiret
Article dans une revue
hal-03949253v1
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Drug Repurposing: Deferasirox Inhibits the Anti-Apoptotic Activity of Mcl-1
Asma Bourafai-Aziez
,
Mohammed Benabderrahmane
,
Hippolyte Paysant
,
Louis-Bastien Weiswald
,
Laurent Poulain
et al.
Article dans une revue
hal-03576776v1
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Structural revision of the Mcl-1 inhibitor MIM1: synthesis and biological studies on ovarian cancer cells with evaluation of designed analogues
Hippolyte Paysant
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Siham Hedir
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Frédéric Justaud
,
Louis Bastien Weiswald
,
Assaad Nasr El Dine
et al.
Article dans une revue
hal-03414007v1
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Cryptic Pockets Repository through Pocket Dynamics Tracking and Metadynamics on Essential Dynamics Space: Applications to Mcl-1
Mohammed Benabderrahmane
,
Ronan Bureau
,
Anne Sophie Voisin-Chiret
,
Jana Sopkova-de Oliveira Santos
Article dans une revue
hal-03961772v1
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Hot-Spots of Mcl-1 Protein
Camille Denis
,
Jana Sopková-de Oliveira Santos
,
Ronan Bureau
,
Anne Sophie Voisin-Chiret
Article dans une revue
hal-03961778v1
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Insights into Mcl-1 Conformational States and Allosteric Inhibition Mechanism from Molecular Dynamics Simulations, Enhanced Sampling, and Pocket Crosstalk Analysis
Mohammed Benabderrahmane
,
Ronan Bureau
,
Anne Sophie Voisin-Chiret
,
Jana Sopkova-de Oliveira Santos
Article dans une revue
hal-03961775v1
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Selecting the first chemical molecule inhibitor of HSP110 for colorectal cancer therapy
Gustavo J. Gozzi
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Daniel Gonzalez
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Christophe Boudesco
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Alexandre M. M. Dias
,
Guillaume Gotthard
et al.
Article dans une revue
hal-02423308v1
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Noncellular screening for the discovery of protein–protein interaction modulators
Charline Kieffer
,
Jean Pierre Jourdan
,
Marie Jouanne
,
Anne Sophie Voisin-Chiret
Article dans une revue
hal-03493870v1
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Synthesis of Pyridoclax Analogues: Insight into Their Druggability by Investigating Their Physicochemical Properties and Interactions with Membranes
Martina de Pascale
,
Domenico Iacopetta
,
Marc Since
,
Sophie Corvaisier
,
V. Vié
et al.
Article dans une revue
hal-02434628v1
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Microplate assay for lipophilicity determination using intrinsic fluorescence of drugs: Application to a promising anticancer lead, pyridoclax
Willy Smeralda
,
Marc Since
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Sophie Corvaisier
,
Rémi Legay
,
Anne-Sophie Voisin-Chiret
et al.
Article dans une revue
hal-02168030v1
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Synthesis of 3,3-Diarylazetidines by Calcium(II)-Catalyzed Friedel–Crafts Reaction of Azetidinols with Unexpected Cbz Enhanced Reactivity
Camille Denis
,
Maryne Dubois
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Anne-Sophie Voisin-Chiret
,
Ronan Bureau
,
Chulho Choi
et al.
Article dans une revue
hal-02043642v1
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Structure-guided design of pyridoclax derivatives based on Noxa / Mcl-1 interaction mode
Siham Hedir
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Marcella de Giorgi
,
Jade Fogha
,
Martina de Pascale
,
Louis-Bastien Weiswald
et al.
Article dans une revue
inserm-01980723v1
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Sequential one pot double C H heteroarylation of thiophene using bromopyridines to synthesize unsymmetrical 2,5-bipyridylthiophenes
Charline Kieffer
,
Victor Babin
,
Marie Jouanne
,
Ikram Slimani
,
Yohann Berhault
et al.
Article dans une revue
istex
hal-02043719v1
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Tau protein aggregation in Alzheimer's disease: An attractive target for the development of novel therapeutic agents
Marie Jouanne
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Sylvain Rault
,
Anne-Sophie Voisin-Chiret
Article dans une revue
hal-02043725v1
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Toward Understanding Mcl-1 Promiscuous and Specific Binding Mode
Jade Fogha
,
Bogdan Marekha
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Marcella de Giorgi
,
Anne-Sophie Voisin-Chiret
,
Sylvain Rault
et al.
Article dans une revue
hal-02043710v1
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Comparison of 2 strategies to enhance pyridoclax solubility: Nanoemulsion delivery system versus salt synthesis
Anne-Claire Groo
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Martina de Pascale
,
Anne-Sophie Voisin-Chiret
,
Sophie Corvaisier
,
Marc Since
et al.
Article dans une revue
istex
hal-02160866v1
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β-Strand Mimicry: Exploring Oligothienylpyridine Foldamers
Marie Jouanne
,
Anne-Sophie Voisin-Chiret
,
Rémi Legay
,
Sébastien Coufourier
,
Sylvain Rault
et al.
Article dans une revue
istex
hal-02043751v1
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Boronic species as promising inhibitors of the Staphylococcus aureus NorA efflux pump: Study of 6-substituted pyridine-3-boronic acid derivatives
Fanny Fontaine
,
Arnaud Héquet
,
Anne-Sophie Voisin-Chiret
,
Alexandre Bouillon
,
Aurélien Lesnard
et al.
Article dans une revue
istex
hal-01170424v1
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First Evidence That Oligopyridines, α-Helix Foldamers, Inhibit Mcl-1 and Sensitize Ovarian Carcinoma Cells to Bcl-x L -Targeting Strategies
Céline Gloaguen
,
Anne-Sophie Voisin-Chiret
,
Jana Sopkova-de Oliveira Santos
,
Jade Fogha
,
Fabien Gautier
et al.
Article dans une revue
hal-02043913v1
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Focus on Microwaves Assisted Halogen-halogen Reaction Conditions on 2-Halopyridines
Serge Perato
,
Marcella de Giorgi
,
Grégory Burzicki
,
Florent Légalité
,
Sylvain Rault
et al.
Current Microwave Chemistry, 2014, 1, pp.1-6
Article dans une revue
hal-00997593v1
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First Identification of Boronic Species as Novel Potential Inhibitors of the Staphylococcus aureus NorA Efflux Pump.
Fanny Fontaine
,
Arnaud Hequet
,
Anne-Sophie Voisin-Chiret
,
Alexandre Bouillon
,
Aurélien Lesnard
et al.
Article dans une revue
hal-00986332v1
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Targeting the BH3 domain of Bcl-2 family proteins. A brief history from natural products to foldamers as promising cancer therapeutic avenues.
Marcella de Giorgi
,
Anne-Sophie Voisin-Chiret
,
Sylvain Rault
Current Medicinal Chemistry, 2013, 20 (24), pp.2964-2978
Article dans une revue
hal-00918387v1
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Conformation control of abiotic α-helical foldamers
Serge Perato
,
Jade Fogha
,
Muriel Sebban
,
Anne-Sophie Voisin-Chiret
,
Jana Sopkova-de Oliveira Santos
et al.
Article dans une revue
hal-00918423v1
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The use of halo (het) arylboronic acids and esters to achieve syntheses of garlands as mimics of alpha helices able to disrupt protein-protein interactions.
Anne-Sophie Voisin-Chiret
,
Sylvain Rault
Pure and Applied Chemistry, 2012, 84, pp.2467-2478
Article dans une revue
hal-00764800v1
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Aromatic garlands, as new foldamers, to mimic protein secondary structure.
Anne-Sophie Voisin-Chiret
,
Grégory Burzicki
,
Serge Perato
,
Marcella de Giorgi
,
Carlo Franchini
et al.
Tetrahedron, 2012, 68, pp.4381-4389
Article dans une revue
hal-00764805v1
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Structural characterizations of oligopyridyl foldamers, α-helix mimetics
Jana Sopkova-de Oliveira Santos
,
Anne-Sophie Voisin-Chiret
,
Grégory Burzicki
,
Laure Sebaoun
,
Muriel Sebban
et al.
Article dans une revue
hal-00996400v1
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Synthesis of new linear poly(phenylpyridyl) chains
Serge Perato
,
Anne-Sophie Voisin-Chiret
,
Jana Sopkova-de Oliveira Santos
,
Rémi Legay
,
Hassan Oulyadi
et al.
Article dans une revue
istex
hal-01015920v1
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Design and synthesis of thienylpyridyl garlands as non-peptidic alpha helix mimetics and potential protein-protein interactions disruptors
Marcella de Giorgi
,
Anne-Sophie Voisin-Chiret
,
Jana Sopkova-de Oliveira Santos
,
Filomena Corbo
,
Carlo Franchini
et al.
Article dans une revue
istex
hal-01061752v1
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296 Evaluating the use of megestrol acetate in Caen and Lisieux CF Centers (2007–2010)
M.V. Guillot
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A.S. Desforges
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Anne-Sophie Voisin-Chiret
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P. Schumann
,
A. Launay
et al.
Journal of Cystic Fibrosis, 2011, 10, pp.S75
Article dans une revue
hal-02045960v1
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Synthesis of New [2,3′:6′,3′′]Terpyridines Using Iterative Cross-Coupling Reactions
Grégory Burzicki
,
Anne-Sophie Voisin-Chiret
,
Jana Sopkova-de Oliveira Santos
,
Sylvain Rault
Article dans une revue
hal-02045907v1
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Synthesis of new phenylpyridyl scaffolds using the Garlanding approach
Anne-Sophie Voisin-Chiret
,
Marilena Muraglia
,
Grégory Burzicki
,
Serge Perato
,
Filomena Corbo
et al.
Article dans une revue
istex
hal-02045957v1
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