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Armelle Rancillac

Neuroscientist Inserm at Collège de France
Current affiliations
Researcher identifiers


**Armelle Rancillac**, PhD, HDR Inserm researcher Neuroglial Interactions in Cerebral Physiopathology CNRS UMR 7241 / Inserm U1050 Center for Interdisciplinary Research in Biology - CIRB Collège de France 11, place Marcelin Berthelot 75005 Paris Armelle Rancillac earned her PhD in Neuroscience in 2003 at Paris VI, while working with Francis Crépel and Hervé Daniel on synaptic plasticity using patch-clamp recordings on cerebellar slices. In her dissertation, she described for the first time, several forms of synaptic plasticity between stellate cells and parallels fibers. Then, she joined Jean Rossier’s laboratory at the ESPCI ParisTech, as a postdoctoral fellow, to study the neurovascular coupling within the cerebellum. Armelle Rancillac demonstrated that cerebellar stellate and Purkinje cells dilate and constrict, respectively, neighboring blood vessels. In 2006, she got a researcher position at the INSERM and focused on the vasomotor control of intracortical blood vessels by interneurons. Combining patch-clamp, RT-PCR, infrared videomicroscopy and Neurolucida reconstructions, she characterized the roles of different interneuron subpopulations in the neurovascular coupling of the mouse somatosensory cortex. Between 2011-2015, Armelle Rancillac studied the role of metabolism on neuronal activity and blood vessel tonus within the ventrolateral preoptic nucleus (VLPO), one of the main brain structures triggering non-rapid eye movement (NREM) sleep. In 2014, she obtained here Habilitations to conduct research (HDR in French). Currently, Armelle Rancillac is working at Collège de France, in Rouach's team, to investigate how neuroglial interactions contributes to the regulation of non-rapid eye movement (NREM) sleep within the ventrolateral preoptic nucleus (VLPO).


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Upregulation of astroglial connexin 30 impairs hippocampal synaptic activity and recognition memory

Eléonore Hardy , Julien Moulard , Augustin Walter , Pascal Ezan , Alexis-Pierre Bemelmans
PLoS Biology, 2023, 21 (4), pp.e3002075. ⟨10.1371/journal.pbio.3002075⟩
Journal articles hal-04083283v1
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NeuroFrance 2023 — from basic neuroscience to translational discoveries

Glenn Dallérac , Armelle Rancillac
Nature Mental Health, 2023, 1 (11), pp.824-826. ⟨10.1038/s44220-023-00136-7⟩
Journal articles hal-04307081v1
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Prostaglandin D 2 Controls Local Blood Flow and Sleep-Promoting Neurons in the VLPO via Astrocyte-Derived Adenosine

Emeric Scharbarg , Augustin Walter , Laure Lecoin , Thierry Gallopin , Frédéric Lemaître
ACS Chemical Neuroscience, inPress, ⟨10.1021/acschemneuro.2c00660⟩
Journal articles hal-04007074v1
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Astroglial Cx30 differentially impacts synaptic activity from hippocampal principal cells and interneurons

Eléonore Hardy , Martine Cohen-Salmon , Nathalie Rouach , Armelle Rancillac
Glia, 2021, Online ahead of print. ⟨10.1002/glia.24017⟩
Journal articles inserm-03207590v3
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Megalencephalic leukoencephalopathy with subcortical cysts is a developmental disorder of the gliovascular unit

Alice Gilbert , Xabier Elorza-Vidal , Armelle Rancillac , Audrey Chagnot , Mervé Yetim
eLife, 2021, 10, ⟨10.7554/eLife.71379⟩
Journal articles hal-03425460v1
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Structural and functional connections between the median and the ventrolateral preoptic nucleus

Augustin Walter , Lorijn van Der Spek , Eléonore Hardy , Alexis Pierre Bemelmans , Nathalie Rouach
Brain Structure and Function, 2019, 224 (9), pp.3045 - 3057. ⟨10.1007/s00429-019-01935-4⟩
Journal articles hal-03230205v1
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Neuropeptide S promotes wakefulness through the inhibition of sleep-promoting VLPO neurons

Frédéric Chauveau , Damien Claverie , Emma Lardant , Christophe Varin , Eléonore Hardy
SLEEP, 2019, Epub ahead of print. ⟨10.1093/sleep/zsz189⟩
Journal articles inserm-02267450v1
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Multiparametric characterization of neuronal subpopulations in the ventrolateral preoptic nucleus

Romain Dubourget , Aude Sangare , Hélène Geoffroy , Thierry Gallopin , Armelle Rancillac
Brain Structure and Function, 2017, 222 (3), pp.1153-1167. ⟨10.1007/s00429-016-1265-2⟩
Journal articles inserm-02126237v1
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Serotonin differentially modulates excitatory and inhibitory synaptic inputs to putative sleep-promoting neurons of the ventrolateral preoptic nucleus

Aude Sangare , Romain Dubourget , Hélène Geoffroy , Thierry Gallopin , Armelle Rancillac
Neuropharmacology, 2016, 109 (1), pp.29-40. ⟨10.1016/j.neuropharm.2016.05.015⟩
Journal articles inserm-02121065v2
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Astrocyte-derived adenosine is central to the hypnogenic effect of glucose

Emeric Scharbarg , Marion Daenens , Frédéric Lemaître , Hélène Geoffroy , Manon Guille-Collignon
Scientific Reports, 2016, 6, pp.19107. ⟨10.1038/srep19107⟩
Journal articles hal-01270584v1
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Serotonin and sleep-promoting neurons

Armelle Rancillac
Oncotarget, 2016, 7 (48), pp.78222-78223. ⟨10.18632/oncotarget⟩
Journal articles inserm-02119508v1
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Glucose Induces Slow-Wave Sleep by Exciting the Sleep-Promoting Neurons in the Ventrolateral Preoptic Nucleus: A New Link between Sleep and Metabolism

Christophe Varin , Armelle Rancillac , Hélène Geoffroy , Sébastien Arthaud , Patrice Fort
Journal of Neuroscience, 2015, 35 (27), pp.9900-9911. ⟨10.1523/JNEUROSCI.0609-15.2015⟩
Journal articles inserm-02121070v1
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Holographic laser Doppler imaging of microvascular blood flow

Caroline Magnain , Amandine Castel , Tanguy Boucneau , Manuel Simonutti , Isabelle Ferezou
Journal of the Optical Society of America. A Optics, Image Science, and Vision, 2014, 31 (12), pp.2723-2735
Journal articles hal-01086781v1
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BDNF-Dependent Plasticity Induced by Peripheral Inflammation in the Primary Sensory and the Cingulate Cortex Triggers Cold Allodynia and Reveals a Major Role for Endogenous BDNF As a Tuner of the Affective Aspect of Pain

Karine Thibault , Wee Khang Lin , Armelle Rancillac , Marie Fan , Thibaut Snollaerts
Journal of Neuroscience, 2014, 34 (44), pp.14739-14751. ⟨10.1523/JNEUROSCI.0860-14.2014⟩
Journal articles inserm-02119514v1
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Characterization of Type I and Type II nNOS-Expressing Interneurons in the Barrel Cortex of Mouse

Quentin Perrenoud , Hélène Geoffroy , Benjamin Gauthier , Armelle Rancillac , Fabienne Alfonsi
Frontiers in Neural Circuits, 2012, 6, pp.36. ⟨10.3389/fncir.2012.00036⟩
Journal articles inserm-02126239v1
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Activation of cortical 5-HT3 receptor-expressing interneurons induces NO mediated vasodilatations and NPY mediated vasoconstrictions

Quentin Perrenoud , Jean Rossier , Isabelle Ferezou , Hélène Geoffroy , Thierry Gallopin
Frontiers in Neural Circuits, 2012, 6, pp.50. ⟨10.3389/fncir.2012.00050⟩
Journal articles inserm-02119566v1
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Impaired neurovascular coupling in the APPxPS1 mouse model of Alzheimer’s disease

Hélène Geoffroy , Jean Rossier , Armelle Rancillac
Current Alzheimer Research, 2012, 9 (10), pp.1221-30. ⟨10.2174/156720512804142859⟩
Journal articles inserm-02121086v1
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Deciphering the Neuronal Circuitry Controlling Local Blood Flow in the Cerebral Cortex with Optogenetics in PV::Cre Transgenic Mice

Alan Urban , Armelle Rancillac , Lucie Martinez , Jean Rossier
Frontiers in Pharmacology, 2012, 3, pp.105. ⟨10.3389/fphar.2012.00105⟩
Journal articles inserm-02119519v1
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Serotonin 3A Receptor Subtype as an Early and Protracted Marker of Cortical Interneuron Subpopulations

Ksenija Vucurovic , Thierry Gallopin , Isabelle Ferezou , Armelle Rancillac , Pascal Chameau
Cerebral Cortex, 2010, 20 (10), pp.2333-2347. ⟨10.1093/cercor/bhp310⟩
Journal articles inserm-02121089v1
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Degenerative abnormalities in transgenic neocortical neuropeptide Y interneurons expressing tau-green fluorescent protein.

Armelle Rancillac , Jeanne Lainé , Quentin Perrenoud , Hélène Geoffroy , Isabelle Ferezou
Journal of Neuroscience Research, 2010, 88 (3), pp.487-99. ⟨10.1002/jnr.22234⟩
Journal articles inserm-00637879v1
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Degenerative abnormalities in transgenic neocortical neuropeptide Y interneurons expressing tau-green fluorescent protein

Armelle Rancillac , Jeanne Lainé , Quentin Perrenoud , Hélène Geoffroy , Isabelle Ferezou
Journal of Neuroscience Research, 2009, 88 (3), pp.487-99. ⟨10.1002/jnr.22234⟩
Journal articles inserm-02126241v1
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High-speed wave-mixing laser Doppler imaging, in vivo.

Michael Atlan , Michel Gross , Tania Vitalis , Armelle Rancillac , Jean Rossier
Optics Letters, 2008, 33 (8 / April 15)
Journal articles hal-00261650v2
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Frequency-domain, wide-field laser Doppler in vivo imaging

Michael Atlan , Michel Gross , Benoit C. Forget , Tania Vitalis , Armelle Rancillac
Optics Letters, 2006, 31 (18), pp.2762-2764
Journal articles hal-00258697v1

Nitric Oxide Release during Evoked Neuronal Activity In Cerebellum Slices. Detection with Platinized Carbon Fiber Microelectrodes

Christian Amatore , Stéphane Arbault , Bruno Cauli , Manon Guille , Armelle Rancillac
ChemPhysChem, 2006, 7 (1), pp.181-187
Journal articles hal-00335533v1
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Nitric Oxide Release during Evoked Neuronal Activity in Cerebellum Slices: Detection with Platinized Carbon-Fiber Microelectrodes

Christian Amatore , Stéphane Arbault , Yann Bouret , Bruno Cauli , Manon Guille
ChemPhysChem, 2006, 7 (1), pp.181-187. ⟨10.1002/cphc.200500202⟩
Journal articles inserm-02126243v1
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Frequency-dependent recruitment of inhibition mediated by stellate cells in the rat cerebellar cortex.

Armelle Rancillac , Jean-Gaël Barbara
Journal of Neuroscience Research, 2005, 80 (3), pp.414-423. ⟨10.1002/jnr.20473⟩
Journal articles inserm-00637825v1
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Synapses between parallel fibres and stellate cells express long-term changes in synaptic efficacy in rat cerebellum

A. Rancillac , F. Crepel
The Journal of Physiology, 2004, 554, pp.707-720. ⟨10.1113/jphysiol.2003.055871⟩
Journal articles hal-00077796v1
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Mechanisms underlying cannabinoid inhibition of presynaptic Ca2+ influx at parallel fibre synapses of the rat cerebellum.

H. Daniel , A. Rancillac , F. Crepel
The Journal of Physiology, 2004, 557, pp.159-174. ⟨10.1113/jphysiol.2004.063263⟩
Journal articles hal-00077808v1
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Cortical GABA interneurons in neurovascular coupling: relays for subcortical vasoactive pathways.

B. Cauli , X.K. Tong , A. Rancillac , N. Serluca , B. Lambolez
Journal of Neuroscience, 2004, 24, pp.8940-8949. ⟨10.1523/JNEUROSCI.3065-04.2004⟩
Journal articles hal-00086334v1
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Bidirectional synaptic plasticity and motor learning in the cerebellum

Armelle Rancillac , Francis Crépel
Physiology News, 2004, ⟨10.36866/pn.55.20⟩
Journal articles inserm-02121125v1
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Expression of Protein Kinase C Inhibitor Blocks Cerebellar Long-Term Depression without Affecting Purkinje Cell Excitability in Alert Mice

Jeroen Goossens , Hervé Daniel , Armelle Rancillac , Johannes van Der Steen , John Oberdick
Journal of Neuroscience, 2001, 21 (15), pp.5813-23
Journal articles inserm-02120677v1
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Rôle du BDNF et des Interactions Neurogliales dans la Régulation du Sommeil Lent

Augustin Walter , Laure Lecoin , Fayçal Rezaig , Frédéric Chauveau , Nathalie Rouach
Le congrès du sommeil, Nov 2021, Lille, France
Conference poster hal-03485294v1

Regulation of BDNF and of neuroglial interactiosn in the VLPO during sleep-wake cycles

A. Walter , L. Lecoin , Nathalie Rouach , Armelle Rancillac
Congrès du sommeil, Jan 2020, Virtual, France
Conference poster hal-04089282v1

Sleep-and wake-dependent changes of sleep-promoting neurons within the VLPO

Armelle Rancillac , A. Walter , F. Chauveau , S. Pezet , F. Canini
FENS, Jan 2020, Virtual Forum, France
Conference poster hal-04089296v1

Impact of Connexin 30 overexpression on astroglial and neuronal networks

E. Hardy , P. Ezan , A-P Bemelmans , F. Mouthon , M. Charvériat
NeuroFrance, Jan 2019, Marseille, France
Conference poster hal-04089782v1

Impact of Connexin 30 overexpression on astroglial and neuronal networks

E. Hardy , P. Ezan , A-P. Bemelmans , F. Mouthon , M. Charvériat
Euroglia, Jan 2019, Porto, Portugal
Conference poster hal-04089378v1

Neuropeptide S promotes wakefulness through the inhibition of sleep-promoting ventrolateral preoptic nucleus neurons

A. Walter , D. Claverie , E. Lardant , E. Hardy , C. Varin
The SLeeping Brain, Jan 2019, Paris, France
Conference poster hal-04089393v1

Neuropeptide S inhibits sleep-promoting neurons into the VLPO to favor wakefulness

Armelle Rancillac , A. Walter , D. Claverie , E. Lardant , E. Hardy
NeuroFrance, Jan 2019, Marseille, France
Conference poster hal-04089401v1