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Arnaud Polizzi

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FGF19 and its analog Aldafermin cooperate with MYC to induce aggressive hepatocarcinogenesis

José Ursic-Bedoya , Guillaume Desandré , Carine Chavey , Pauline Marie , Arnaud Polizzi
EMBO Molecular Medicine, 2024, ⟨10.1038/s44321-023-00021-x⟩
Article dans une revue hal-04404913v1
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p110α-dependent hepatocyte signaling is critical for liver gene expression and its rewiring in MASLD

Marion Régnier , Arnaud Polizzi , Tiffany Fougeray , Anne Fougerat , Prunelle Perrier
Article dans une revue hal-04442467v1

Continuous low-level dietary exposure to glyphosate elicits dose and sex-dependent synaptic and microglial adaptations in the rodent brain.

Noemie Cresto , Margot Courret , Athénaïs Génin , Céline Marie Pauline Martin , Julie Bourret
Environmental Pollution, 2024, 345, pp.123477. ⟨10.1016/j.envpol.2024.123477⟩
Article dans une revue hal-04444827v1

Intestinal Pgc1α ablation protects from liver steatosis and fibrosis

Elena Piccinin , Maria Arconzo , Maria Laura Matrella , Marica Cariello , Arnaud Polizzi
JHEP Reports Innovation in Hepatology, 2023, pp.100853. ⟨10.1016/j.jhepr.2023.100853⟩
Article dans une revue hal-04219698v1
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Dietary Amino Acid Source Elicits Sex‐Specific Metabolic Response to Diet‐Induced NAFLD in Mice

Clémence Rives , Céline Marie Pauline Martin , Lauris Evariste , Arnaud Polizzi , Marine Huillet
Molecular Nutrition and Food Research, 2023, ⟨10.1002/mnfr.202300491⟩
Article dans une revue hal-04287354v1

Obesity promotes fumonisin B1 hepatotoxicity

Léonie Dopavogui , Marion Régnier , Arnaud Polizzi , Quentin Ponchon , Sarra Smati
Science of the Total Environment, 2023, 891, pp.164436. ⟨10.1016/j.scitotenv.2023.164436⟩
Article dans une revue hal-04112262v1
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The interplay between dietary fatty acids and gut microbiota influences host metabolism and hepatic steatosis

Marc Schoeler , Sandrine Ellero-Simatos , Till Birkner , Jordi Mayneris-Perxachs , Lisa Olsson
Nature Communications, 2023, 14 (1), pp.5329. ⟨10.1038/s41467-023-41074-3⟩
Article dans une revue hal-04197137v1
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ATGL-dependent white adipose tissue lipolysis controls hepatocyte PPARα activity

Anne Fougerat , Gabriele Schoiswohl , Arnaud Polizzi , Marion Régnier , Carina Wagner
Cell Reports, 2022, 39 (10), ⟨10.1016/j.celrep.2022.110910⟩
Article dans une revue hal-03695833v1
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The hepatocyte insulin receptor is required to program the liver clock and rhythmic gene expression

Tiffany Fougeray , Arnaud Polizzi , Marion Régnier , Anne Fougerat , Sandrine Ellero-Simatos
Cell Reports, 2022, 39 (2), pp.110674. ⟨10.1016/j.celrep.2022.110674⟩
Article dans une revue hal-03647009v1
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Tissular Genomic Responses to Oral FB1 Exposure in Pigs

Léonie Dopavogui , Arnaud Polizzi , Anne Fougerat , Pascal Gourbeyre , Chloé Terciolo
Toxins, 2022, 14 (2), pp.83. ⟨10.3390/toxins14020083⟩
Article dans une revue hal-03609600v1

ATGL-dependent white adipose tissue lipolysis controls hepatocyte PPARα activity

Anne Fougerat , Gabriele Schoiswohl , Arnaud Polizzi , Marion Régnier , Carina Wagner
Cell Reports, 2022, 39 (10), pp.110910. ⟨10.1016/j.celrep.2022.110910⟩
Article dans une revue hal-04303269v1
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Nuclear HMGB1 protects from nonalcoholic fatty liver disease through negative regulation of liver X receptor

Jean Personnaz , Enzo Piccolo , Alizée Dortignac , Jason Iacovoni , Jérôme J. Mariette
Science Advances , 2022, 8 (12), ⟨10.1126/sciadv.abg9055⟩
Article dans une revue hal-03624265v1
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Pre- and Postnatal Dietary Exposure to a Pesticide Cocktail Disrupts Ovarian Functions in 8-Week-Old Female Mice

Léonie Dopavogui , Florence Cadoret , Gaspard Loison , Sara El Fouikar , François-Xavier Frenois
International Journal of Molecular Sciences, 2022, 23 (14), pp.7525. ⟨10.3390/ijms23147525⟩
Article dans une revue hal-03727259v1
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Integrative study of diet-induced mouse models of NAFLD identifies PPARα as a sexually dimorphic drug target

Sarra Smati , Arnaud Polizzi , Anne Fougerat , Sandrine Ellero-Simatos , Yuna Blum
Gut, 2022, 71 (4), pp.807-821. ⟨10.1136/gutjnl-2020-323323⟩
Article dans une revue hal-03215969v1
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Endoplasmic reticulum stress controls iron metabolism through TMPRSS6 repression and hepcidin mRNA stabilization by RNA-binding protein HuR

Audrey Belot , Ophélie Gourbeyre , Anais Palin , Aude Rubio , Amélie Largounez
Haematologica, 2021, 106 (4), pp.1202-1206. ⟨10.3324/haematol.2019.237321⟩
Article dans une revue hal-02911817v1

Dual regulation of TxNIP by ChREBP and FoxO1 in liver

Benedicte Noblet , Fadila Benhamed , Insug O-Sullivan , Wenwei Zhang , Gaëlle Filhoulaud
iScience, 2021, 24 (3), pp.102218. ⟨10.1016/j.isci.2021.102218⟩
Article dans une revue hal-03963490v1
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The pregnane X receptor drives sexually dimorphic hepatic changes in lipid and xenobiotic metabolism in response to gut microbiota in mice

Sharon Barretto , Frédéric Lasserre , Marine Huillet , Marion Régnier , Arnaud Polizzi
Article dans une revue hal-03209709v1
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Dual regulation of TxNIP by ChREBP and FoxO1 in liver

Bénédicte Noblet , Fadila Benhamed , Insug O-Sullivan , Wenwei Zhang , Gaelle Filhoulaud
iScience, 2021, 24 (3), pp.102218. ⟨10.1016/j.isci.2021.102218⟩
Article dans une revue hal-03176271v1
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Regulation of hepatokine gene expression in response to fasting and feeding: Influence of PPARa and insulin-dependent signaling in hepatocytes

Sarra Smati , Marion Régnier , Tiffany Fougeray , Arnaud Polizzi , Anne Fougerat
Diabetes & Metabolism, 2020, 46 (2), pp.129-136. ⟨10.1016/j.diabet.2019.05.005⟩
Article dans une revue hal-02402566v1
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Perinatal exposure to a dietary pesticide cocktail does not increase susceptibility to high-fat diet-induced metabolic perturbations at adulthood but modifies urinary and fecal metabolic fingerprints in C57Bl6/J mice

Lorraine Smith , Wendy Klement , Léonie Dopavogui , Frédéric de Bock , Frédéric Lasserre
Environment International, 2020, 144, pp.106010. ⟨10.1016/j.envint.2020.106010⟩
Article dans une revue hal-02912899v1
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Transcriptomic modifications of the thyroid gland upon exposure to phytosanitary-grade fipronil: Evidence for the activation of compensatory pathways

Pascal G.P. Martin , Véronique Dupouy-Guiraute , Julien Leghait , Thierry Pineau , Arnaud Polizzi
Toxicology and Applied Pharmacology, 2020, 389, 14 p. ⟨10.1016/j.taap.2019.114873⟩
Article dans une revue hal-02624912v1
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Hepatocyte-specific deletion of Pparα promotes NAFLD in the context of obesity

Marion Régnier , Arnaud Polizzi , Sarra Smati , Céline Lukowicz , Anne Fougerat
Scientific Reports, 2020, 10 (1), pp.6489. ⟨10.1038/s41598-020-63579-3⟩
Article dans une revue inserm-02875414v1
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Proton NMR enables the absolute quantification of aqueous metabolites and lipid classes in unique mouse liver samples

Aurélien Amiel , Marie Tremblay-Franco , Roselyne Gautier , Simon Ducheix , Alexandra Montagner
Metabolites, 2020, 10 (1), 20 p. ⟨10.3390/metabo10010009⟩
Article dans une revue hal-02622894v1
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Author correction: Dimorphic metabolic and endocrine disorders in mice lacking the constitutive androstane receptor

Céline Lukowicz , Sandrine Ellero-Simatos , Marion Régnier , Fabiana Oliviero , Frédéric Lasserre
Scientific Reports, 2020, 10 (1), ⟨10.1038/s41598-020-61226-5⟩
Article dans une revue hal-02627769v1

Hepatic PPARα is critical in the metabolic adaptation to sepsis

Réjane Paumelle , Joel Haas , Nathalie Hennuyer , Eric Baugé , Yann Deleye
Journal of Hepatology, 2019, 70 (5), pp.963-973. ⟨10.1016/j.jhep.2018.12.037⟩
Article dans une revue hal-04397660v1
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The protective role of liver X receptor (LXR) during fumonisin B1-induced hepatotoxicity

Marion Régnier , Arnaud Polizzi , Céline Lukowicz , Sarra Smati , Frédéric Lasserre
Archives of Toxicology, 2019, 93 (2), pp.505-517. ⟨10.1007/s00204-018-2345-2⟩
Article dans une revue hal-02619117v1
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Dimorphic metabolic and endocrine disorders in mice lacking the constitutive androstane receptor

Céline Lukowicz , Sandrine Ellero-Simatos , Marion Régnier , Fabiana Oliviero , Frédéric Lasserre
Scientific Reports, 2019, 9 (1), ⟨10.1038/s41598-019-56570-0⟩
Article dans une revue hal-02428712v1
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Gene expression profiling reveals that PXR activation inhibits Hhepatic PPAR alpha activity and decreases FGF21 secretion in male C57Bl6/J mice

Sharon Barretto , Frédéric Lasserre , Anne Fougerat , Lorraine Smith , Tiffany Fougeray
International Journal of Molecular Sciences, 2019, 20 (15), ⟨10.3390/ijms20153767⟩
Article dans une revue hal-02617929v1
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Hepatic PPARα is critical in the metabolic adaptation to sepsis

Réjane Paumelle , Joel T Haas , Nathalie Hennuyer , Eric Baugé , Yann Deleye
Journal of Hepatology, 2019, 70 (5), pp.963-973. ⟨10.1016/j.jhep.2018.12.037⟩
Article dans une revue hal-04358206v1

Sphingolipid metabolism in non-alcoholic fatty liver diseases

Marion Régnier , Arnaud Polizzi , Hervé Guillou , Nicolas Loiseau
Biochimie, 2019, 159, pp.9-22. ⟨10.1016/j.biochi.2018.07.021⟩
Article dans une revue hal-02626541v1
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Hepatic PPARalpha is critical in the metabolic adaptation to sepsis

Réjane Paumelle , Joël Haas , Nathalie Hennuyer , Eric Baugé , Yann Deleye
Journal of Hepatology, 2019, 70 (5), pp.963-973. ⟨10.1016/j.jhep.2018.12.037⟩
Article dans une revue inserm-02109735v1
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Dual extraction of mRNA and lipids from a single biological sample

Normand Podechard , Simon Ducheix , Arnaud Polizzi , Frédéric Lasserre , Alexandra Montagner
Scientific Reports, 2018, 8 (1), pp.7019. ⟨10.1038/s41598-018-25332-9⟩
Article dans une revue hal-01794296v1
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Metabolic effects of a chronic dietary exposure to a low-dose oesticide cocktail in mice: Sexual dimorphism and role of the constitutive androstane receptor

Céline Lukowicz , Sandrine Ellero-Simatos , Marion Régnier , Arnaud Polizzi , Frédéric Lasserre
Environmental Health Perspectives, 2018, 126 (6), 18 p. ⟨10.1289/EHP2877⟩
Article dans une revue hal-02624889v1
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A Specific ChREBP and PPARα Cross-Talk Is Required for the Glucose-Mediated FGF21 Response

Alison Iroz , Alexandra Montagner , Fadila Benhamed , Françoise Levavasseur , Arnaud Polizzi
Cell Reports, 2017, 21 (2), pp.403 - 416. ⟨10.1016/j.celrep.2017.09.065⟩
Article dans une revue hal-01837159v1
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Dietary oleic acid regulates hepatic lipogenesis through a liver X receptor-dependent signaling

Simon Ducheix , Alexandra Montagner , Arnaud Polizzi , Frédéric Lasserre , Marion Régnier
PLoS ONE, 2017, 12 (7), ⟨10.1371/journal.pone.0181393⟩
Article dans une revue hal-01606929v1

Insights into the role of hepatocyte PPARα activity in response to fasting

Marion Régnier , Arnaud Polizzi , Yannick Lippi , Edwin Fouché , Géraldine Michel
Molecular and Cellular Endocrinology, 2017, in press, ⟨10.1016/j.mce.2017.07.035⟩
Article dans une revue hal-01605514v1
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Hepatic fasting-induced PPAR alpha activity does not depend on essential fatty acids

Arnaud Polizzi , Edwin Fouché , Simon Ducheix , Frédéric Lasserre , Alice Marmugi
International Journal of Molecular Sciences, 2016, 17 (10), pp.1624. ⟨10.3390/ijms17101624⟩
Article dans une revue hal-01476503v1
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Hepatic circadian clock oscillators and nuclear receptors integrate microbiome-derived signals

Alexandra Montagner , Agata Korecka , Arnaud Polizzi , Yannick Lippi , Yuna Blum
Scientific Reports, 2016, 6 (1), pp.1-14. ⟨10.1038/srep20127⟩
Article dans une revue hal-01482816v1
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Activation of the Constitutive Androstane Receptor induces hepatic lipogenesis and regulates Pnpla3 gene expression in a LXR-independent way

Alice Marmugi , Céline Lukowicz , Frédéric Lasserre , Alexandra Montagner , Arnaud Polizzi
Toxicology and Applied Pharmacology, 2016, 303, pp.90 - 100. ⟨10.1016/j.taap.2016.05.006⟩
Article dans une revue hal-01837194v1
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Liver PPARα is crucial for whole-body fatty acid homeostasis and is protective against NAFLD

Alexandra Montagner , Arnaud Polizzi , Edwin Fouché , Simon Ducheix , Yannick Lippi
Gut, 2016, 65 (7), pp.1202-1214. ⟨10.1136/gutjnl-2015-310798⟩
Article dans une revue inserm-02339685v1
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New insights into the organ-specific adverse effects of fumonisin B1

Nicolas Loiseau , Arnaud Polizzi , Aude Dupuy , Nicole Therville , Mirindra Rakotonirainy
Archives of Toxicology, 2015, 89 (9), pp.1619-1629. ⟨10.1007/s00204-014-1323-6⟩
Article dans une revue hal-03331305v1

Adverse effects of long-term exposure to bisphenol A during adulthood leading to hyperglycaemia and hypercholesterolemia in mice

Alice Marmugi , Frédéric Lasserre , Diane Beuzelin , Simon Ducheix , Laurence Huc
Toxicology, 2014, 325, pp.133-143. ⟨10.1016/j.tox.2014.08.006⟩
Article dans une revue hal-02641668v1

A systems biology approach to the hepatic role of the oxysterol receptor LXR in the regulation of lipogenesis highlights a cross-talk with PPARα.

Simon Ducheix , Normand Podechard , Frédéric Lasserre , Arnaud Polizzi , Aurélien Pommier
Biochimie, 2013, 95 (3), pp.556-67. ⟨10.1016/j.biochi.2012.09.028⟩
Article dans une revue inserm-00872582v1

Essential fatty acids deficiency promotes lipogenic gene expression and hepatic steatosis through the liver X receptor.

Simon Ducheix , Alexandra Montagner , Arnaud Polizzi , Frédéric Lasserre , Alice Marmugi
Journal of Hepatology, 2013, 58 (5), pp.984-92. ⟨10.1016/j.jhep.2013.01.006⟩
Article dans une revue inserm-00872314v1
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Proteinase-activated receptor-4 evoked colorectal analgesia in mice: an endogenously activated feed-back loop in visceral inflammatory pain

Anita Annahazi , Marta-Ewa Dabek , K Gecse , Christel Cartier , Arnaud Polizzi
Neurogastroenterology & Motility, 2012, 24 (1), pp.76-85. ⟨10.1111/j.1365-2982.2011.01805.x⟩
Article dans une revue hal-01228309v1
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Low Doses of Bisphenol A Induce Gene Expression Related to Lipid Synthesis and Trigger Triglyceride Accumulation in Adult Mouse Liver

Alice Marmugi , Simon Ducheix , Frédéric Lasserre , Arnaud Polizzi , Alain Paris
Hepatology, 2012, 55 (2), pp.395-407. ⟨10.1002/hep.24685⟩
Article dans une revue hal-01019497v1

Intracolonic infusion of fecal supernatants from ulcerative colitis patients triggers altered permeability and inflammation in mice: Role of cathepsin G and protease‐activated receptor‐4

Marta-Ewa Dabek , Laurent Ferrier , Anita Annahazi , Valérie Bézirard , Arnaud Polizzi
Inflammatory Bowel Diseases, 2011, 17 (6), pp.1409-1414. ⟨10.1002/ibd.21454⟩
Article dans une revue hal-02645072v1
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Impact of oral bisphenol A at reference doses on intestinal barrier function and sex differences after perinatal exposure in rats

Viorica Braniste , Aurore . Jouault , Eric Gaultier , Arnaud Polizzi , Claire Buisson
Proceedings of the National Academy of Sciences of the United States of America, 2010, 107 (1), pp.448-453. ⟨10.1073/pnas.0907697107⟩
Article dans une revue hal-01608653v1

Effects of Illicit Dexamethasone upon Hepatic Drug Metabolizing Enzymes and Related Transcription Factors mRNAs and Their Potential Use As Biomarkers in Cattle

Mery Giantin , Rosa M Lopparelli , Vanessa Zancanella , Pascal G.P. Martin , Arnaud Polizzi
Journal of Agricultural and Food Chemistry, 2010, 58 (2), pp.1342-1349. ⟨10.1021/jf9033317⟩
Article dans une revue hal-02660372v1
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Di-(2-ethylhexyl)-phthalate (DEHP) activates the Constitutive Androstane Receptor (CAR): a novel signalling pathway sensitive to phthalates

Alexandre Eveillard , Laila Mselli-Lakhal , Ariane Mogha , Frédéric Lasserre , Arnaud Polizzi
Biochemical Pharmacology, 2009, 77 (11), pp.1735. ⟨10.1016/j.bcp.2009.02.023⟩
Article dans une revue hal-00493499v1

Identification of potential mechanisms of toxicity after di-(2-ethylhexyl)-phthalate (DEHP) adult exposure in the liver using a systems biology approach

Alexandre Eveillard , Frédéric Lasserre , M de Tayrac , Arnaud Polizzi , S Claus
Toxicology and Applied Pharmacology, 2009, 236 (3), pp.282-292. ⟨10.1016/j.taap.2009.02.008⟩
Article dans une revue hal-02662270v1

Effets d’une exposition alimentaire, périnatale et chronique alimentaire, à des doses réglementaires de glyphosate sur l’axe microbiote intestinal-intestin-foie

Lorraine Smith , Céline Martin , Sabrine Naimi , Beatrice Engelmann , Frédéric Lasserre
13ème congrès annuel de la Société Francophone de Santé et Environnement, Nov 2022, Valence, France
Communication dans un congrès hal-03775382v1

Influence of gender on progression of liver metabolic diseases in response to different nutritional challenges

Sarra Smati , Arnaud Polizzi , Marion Régnier , Alain Marrot , Céline Lukowicz
54. Annual Meeting of the European-Association-for-the-Study-of-Diabetes (EASD), European Association for the Study of Diabetes (EASD). GBR., Oct 2018, Berlin, Germany. pp.1
Communication dans un congrès hal-02735253v1

Hepatokines in metabolic disease: novel insights into FGF21 regulation by glucose

Catherine Postic , Alison Iroz , Alexandra Montagner , Fadila Benhamed , Arnaud Polizzi
52. Annual Scientific Meeting of the European Society for Clinical Investigation “Precision medicine for healthy ageing”, May 2018, Barcelone, Spain. pp.1
Communication dans un congrès hal-02734271v1

Constitutive Androstane Receptor deficiency leads to sexually dimorphic metabolic disorders in aging

Céline Lukowicz , Marion Régnier , Frédéric Lasserre , Arnaud Polizzi , Alexandra Montagner
54. Annual Meeting of the European-Association-for-the-Study-of-Diabetes (EASD), European Association for the Study of Diabetes (EASD). GBR., Oct 2018, Berlin, France. pp.1
Communication dans un congrès hal-02735254v1
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Hepatocyte PI3Kα controls the PPARα-FGF21 axis and regulates whole body fatty acid homeostasis

Marion Régnier , Arnaud Polizzi , Céline Lukowicz , S. Smati , Anne Fougerat
European Assocation for the Study of Diabetes (EASD), Oct 2018, Berlin, Germany
Communication dans un congrès hal-04442612v1
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Hepatocyte PI3Kα controls the PPARα-FGF21 axis and regulates whole body fatty acid homeostasis

Marion Régnier , Arnaud Polizzi , Céline Lukowicz , Edwin Fouché , Frédéric Lasserre
EMBO meeting, Apr 2017, Majorqua, Spain
Communication dans un congrès hal-04442626v1
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Hepatic thyroid hormone transport and thyroid hormone metabolism interplay might be involved in fipronil-induced disruption of thyroid homeostasis

Béatrice Roques , Marlène Z. Lacroix , Elisabeth Perdu , Arnaud Polizzi , Frédéric Lasserre
Congrès du Programme National de Recherche sur les Pertubateurs Endocriniens, Programme National de Recherche sur les Pertubateurs Endocriniens (PNRPE)., Dec 2012, Paris, France. 2p
Communication dans un congrès hal-02746012v1

Régulation du Liver X Receptor par le fructose et développement de la stéatose hépatique

Simon Ducheix , F Rayah-Benhamed , Alexandra Montagner , Arnaud Polizzi , Frédéric Lasserre
9. Journées Francophones de Nutrition (JFN), Ville service., Dec 2011, Reims, France
Communication dans un congrès hal-02805683v1

The application of microarrays to food safety issues : gene expression analysis in circulating lymphocytes from cattle illegally treated with dexamethasone for growth promoting purposes

Alessandra Balbo , Arnaud Polizzi , Pgp Martin , Michela Cantiello , D Bertarelli
10th National Biotechnology Congress, 2008, Perugia, Italy. pp.Inconnu
Communication dans un congrès hal-02817179v1

Biological signatures to detect horse doping by equine hormones: myth or reality?

Arnaud Polizzi , M Grall , V Mercader , Frédéric Lasserre , J Matéo
60th Meeting of the Association of Official Racing Chemists, 2007, Paris, France. pp.Inconnu
Communication dans un congrès hal-02819753v1