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Ata Martin LAWSON

Maître de conférences (HDR), URCOM
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![](https://) Ata Martin LAWSON was born in Tsévié (Togo) in 1974. He studied at Joseph Fourier University of Grenoble, France, graduating in 2002. He worked on aurone analogs’ synthesis as potent P-gp (P-glycoprotein) inhibitors in DPM Laboratory with Pr. Ahcene Boumendjel. He also worked on flavonoid synthesis in the same laboratory. In October 2002, he moved to the University of Limoges as PhD student where he has been interested in the extraction of rotenoids and, the chemistry of natural polyphenols of the Fabaceae family. After becoming a doctor by defending his PhD in 2006, he moved to the University of Reims as an Assistant Professor in the Medicinal Chemistry Laboratory of Pr. Janos Sapi. He stayed there for two years before acquiring a permanent position as an Associate Professor at Le Havre University in 2009. He then joined the team of Pr. Adam DAÏCH at URCOM laboratory. His current research interests include natural product chemistry (phytochemistry) as well as the synthesis of novel heterocycles using chromone derivatives as starting materials following The DOS (Diversity Oriented Synthesis) strategy and finally the development of hybrid molecules synthesis with diverse biological activities. **# 1. L'axe de recherche : Axe 1. Chimie durable et Santé** **# 2. Thème de recherche** **# 3. Mots-clés** **# 4. Production Scientifique** Publications : 48 Chapitres de livre : 0 Conférences invitées : 15 .

Research domains

Organic chemistry Medicinal Chemistry

Skills

Synthèse organique Réactions domino Extraction et modification de produits naturels Synthèse de molécules hybrides Activité anticancer, antibactérienne, antibiofilm et antifongique

Publications

Design, semi-synthesis and molecular docking of new antibacterial and antibiofilm triazole conjugates from hydroxy-triterpene acids and fluoroquinolones

Besma Boulila , Mabrouk Horchani , Raphael Duval , Mohamed Othman , Adam Daïch
New Journal of Chemistry, 2023, 47 (34), pp.15973-15986. ⟨10.1039/d3nj02922k⟩
Journal articles hal-04262728v1

Five‐Membered Nitrogen Heterocycles Synthesis through 1,3‐Dipolar Cycloaddition of Non‐Stabilized Azomethine Ylides with 2‐Pyridone Heteroaromatic Systems as Dipolarophiles

Sami Ben Salah , Morgane Sanselme , Yves Champavier , Mohamed Othman , Adam Daïch
European Journal of Organic Chemistry, 2021, 2021 (1), pp.102-116. ⟨10.1002/ejoc.202001404⟩
Journal articles hal-03963331v1

Access to 3-spiroindolizines containing an isoindole ring through intra-molecular arylation of spiro-N-acyliminium species: a new family of potent farnesyltransferase inhibitors

Anthony Pesquet , Hamid Marzag , Michael Knorr , Carsten Strohmann , Ata Martin Lawson
Organic & Biomolecular Chemistry, 2019, 17 (10), pp.2798-2808. ⟨10.1039/c8ob02612b⟩
Journal articles hal-02332627v1

Highly Enantioselective Semisynthesis of (+)/(−)-Gossypol Schiff Base Derivatives from Ground Plant Material

Mohamed Sidi Boune , Brahim Elemine , Ahmed Aliyenne , Abderrahmane Hadou , Adam Daïch
Journal of Natural Products, 2019, 82 (7), pp.1779-1790. ⟨10.1021/acs.jnatprod.8b01045⟩
Journal articles hal-02332614v1

Phenyliodine(III) Diacetate/I 2 ‐Mediated Domino Approach for Pyrrolo[1,4]Thiazines and 1,4‐Thiazines by a One‐Pot Morin Rearrangement of N,S ‐ Acetals

Fanny Danton , Mohamed Othman , Ata Martin Lawson , Ján Moncol , Alina Ghinet
Chemistry - A European Journal, 2019, 25 (24), pp.6113-6118. ⟨10.1002/chem.201901111⟩
Journal articles hal-02563783v1

Indolylglycines Backbones in the Synthesis of Enantiopure 3,3-Spiroindolenines, Indolyl Tetracyclic Hemiaminals, and 3-Indolyl-maleimides Frameworks

Jozef Markus , Branislav Ferko , Dušan Berkeš , Ján Moncol , Ata Martin Lawson
European Journal of Organic Chemistry, 2019, 2019 (33), pp.5662-5677. ⟨10.1002/ejoc.201900814⟩
Journal articles hal-02332612v1
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Benzo[7,8]indolizinoquinoline scaffolds based on Mg(ClO4)2-promoted regiospecific imide reduction and π-cyclization of N-acyliminium species. Analogues of the topo-1 poison rosettacin and 22-hydroxyacuminatine alkaloids

Abdulkareem Hamid , Abdelaziz Souizi , Ata Martin Lawson , Mohamed Othman , Alina Ghinet
Arabian Journal of Chemistry, 2019, 12 (5), pp.680-693. ⟨10.1016/j.arabjc.2018.03.009⟩
Journal articles hal-02413296v1

Design and semisynthesis of new herbicide as 1,2,3-triazole derivatives of the natural maslinic acid

Aymen Ben Nejma , Mansour Znati , Adam Daïch , Mohamed Othman , Ata Martin Lawson
Steroids, 2018, 138, pp.102-107. ⟨10.1016/j.steroids.2018.07.004⟩
Journal articles hal-02332632v1

Structure-Based Kinetic Control in a Domino Process: A Powerful Tool Toward Molecular Diversity in Chromone Series

Thomas Lepitre , Clément Denhez , Jan Moncol , Mohamed Othman , Ata Martin Lawson
Journal of Organic Chemistry, 2017, 82 (23), pp.12188-12201. ⟨10.1021/acs.joc.7b01996⟩
Journal articles hal-02332616v1

Phytochemical and biological studies of Atriplex inflata f. Muell.: isolation of secondary bioactive metabolites

Aymen Ben Nejma , Mansour Znati , Asma Nguir , Adam Daïch , Mohamed Othman
Journal of Pharmacy and Pharmacology, 2017, 69 (8), pp.1064-1074. ⟨10.1111/jphp.12735⟩
Journal articles hal-02332617v1

Metal-Free Cascade Approach toward Polysubstituted Indolizines from Chromone-Based Michael Acceptors

Thomas Lepitre , Raphael Le Biannic , Mohamed Othman , Ata Martin Lawson , Adam Daïch
Organic Letters, 2017, 19 (8), pp.1978-1981. ⟨10.1021/acs.orglett.7b00309⟩
Journal articles hal-02332628v1

Development of SECheM Concept for Isolation and Chemical Modification of Gossypol Directly from Cienfuegosia digitata

Mohamed Vall Sidi Boune , Brahim Ould Elemine , Thomas Lepitre , Abderrahmane Ould Hadou , Ahmed Aliyenne
Phytochemical Analysis, 2017, 28 (5), pp.410-415. ⟨10.1002/pca.2688⟩
Journal articles hal-02332630v1

Original Mitsunobu-Triggered Sequence Involved in a One-Pot Domino Process toward Tetracyclic Systems Bearing a Bis- N , O -acetal Junction

Thomas Lepitre , Clément Denhez , Morgane Sanselme , Mohamed Othman , Ata Martin Lawson
Journal of Organic Chemistry, 2016, 81 (19), pp.8837 - 8849. ⟨10.1021/acs.joc.6b01523⟩
Journal articles hal-01928655v1

Competitive intramolecular C–C vs. C–O bond coupling reactions toward C 6 ring-fused 2-pyridone synthesis

T. Lepitre , C. Pintiala , K. Muru , S. Comesse , A. Rebbaa
Organic & Biomolecular Chemistry, 2016, 14 (14), pp.3564-3573. ⟨10.1039/c6ob00303f⟩
Journal articles hal-02332624v1

Bi(OTf) 3 -Catalysed Access to 2,3-Substituted Isoindolinones and Tricyclic N,O-Acetals by Trapping of Bis- N -Acyliminium Species in a Tandem Process

Ahmed Aliyenne , Frédéric Pin , Vijaykumar Nimbarte , Ata Martin Lawson , Sébastien Comesse
European Journal of Organic Chemistry, 2016, 2016 (21), pp.3592-3602. ⟨10.1002/ejoc.201600530⟩
Journal articles hal-01928678v1
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Use of chiral-pool approach into epi-thieno analogues of the scarce bioactive phenanthroquinolizidine alkaloids

Peter Šafář , Štefan Marchalín , Nadežda Prónayová , Viktor Vrábel , Ata Martin Lawson
Tetrahedron, 2016, 72 (23), pp.3221-3231. ⟨10.1016/j.tet.2016.04.047⟩
Journal articles hal-02413311v1

Highly Stereoselective Domino Oxa-Michael/Aza-Michael/Cyclization Synthesis of Bicyclic Lactams and Spirooxindole Skeleton

R. Le Goff , M. Sanselme , Ata Martin Lawson , Adam Daïch , Sébastien Comesse
European Journal of Organic Chemistry, 2015, 2015 (33), pp.7244-7248. ⟨10.1002/ejoc.201501072⟩
Journal articles hal-02413286v1

Expeditious Synthesis of the Topoisomerase I Inhibitors Isoindolo[2,1-b]isoquinolin-7(5H)-one and the Alkaloid Rosettacin Based on Aryl Radical Cyclization of Enamide Generated by Using N-Acyl­iminium Chemistry

Ata Martin Lawson , Lahssen El Blidi , Aurélie Namoune , Alexandre Bridoux , Vijaykumar Nimbarte
Synthesis: Journal of Synthetic Organic Chemistry, 2015, 47 (22), pp.3583-3592. ⟨10.1055/s-0034-1378811⟩
Journal articles hal-02332633v1

New septanoside and 20-hydroxyecdysone septanoside derivative from Atriplex portulacoides roots with preliminary biological activities

Aymen Ben Nejma , Asma Nguir , Hichem Ben Jannet , M’hamed Ali Hamza , Adam Daïch
Bioorganic and Medicinal Chemistry Letters, 2015, 25 (8), pp.1665-1670. ⟨10.1016/j.bmcl.2015.03.028⟩
Journal articles hal-02413288v1

Simple Access to Highly Functional Bicyclic γ- and δ-Lactams: Origins of Chirality Transfer to Contiguous Tertiary/Quaternary Stereocenters Assessed by DFT

Ronan Le goff , Arnaud Martel , Morgane Sanselme , Ata Martin Lawson , Adam Daïch
Chemistry - A European Journal, 2015, 21 (7), pp.2966 - 2979. ⟨10.1002/chem.201405094⟩
Journal articles hal-01929393v1

Synthesis of novel chiral 1,4-dihydropyridinyl Schiff-base ligands, with characterization and evaluation of calcium channel blocker activity

Štefan Marchalín , Dušan Valigura , Ľudovít Varečka , Boris Lakatoš , Monika Vaneková
Chemical Monthly = Monatshefte für Chemie, 2014, 145 (5), pp.835-847. ⟨10.1007/s00706-014-1164-2⟩
Journal articles hal-02332621v1

En-route to scarce furo[3,2-f]indolizidines, -indolizidin-9-ols and their stable quaternary ammonium salts based on the stereoselective catalytic hydrogenation of furan nucleus

Peter Šafář , Štefan Marchalín , Jozefína Žúžiová , Nadežda Prónayová , Ata Martin Lawson
Tetrahedron, 2014, 70 (37), pp.6506-6514. ⟨10.1016/j.tet.2014.07.018⟩
Journal articles hal-02564863v1

A versatile domino process for the synthesis of substituted 3-aminomethylene-chromanones and 2-pyridones catalyzed by CsF

Catalin Pintiala , Ata Martin Lawson , Sébastien Comesse , Adam Daïch
Tetrahedron Letters, 2013, 54 (22), pp.2853-2857. ⟨10.1016/j.tetlet.2013.03.096⟩
Journal articles hal-02564869v1

Synthesis of highly functionalized pyrrolidines as tunable templates for the direct access to (±)-coerulescine and the tricyclic core of martinellines

Ronan Le Goff , Ata Martin Lawson , Adam Daïch , Sébastien Comesse
Organic & Biomolecular Chemistry, 2013, 11 (11), pp.1818. ⟨10.1039/c3ob27472a⟩
Journal articles hal-02332622v1

Tandem aza-Michael/spiro-ring closure sequence: access to a versatile scaffold and total synthesis of (±)-coerulescine

Meral Görmen , Ronan Le Goff , Ata Martin Lawson , Adam Daïch , Sébastien Comesse
Tetrahedron Letters, 2013, 54 (17), pp.2174-2176. ⟨10.1016/j.tetlet.2013.02.047⟩
Journal articles hal-02564870v1

ChemInform Abstract: 4-Hydroxy-6-methoxyaurones with High-Affinity Binding to Cytosolic Domain of P-Glycoprotein.

Ata Martin Lawson , Ahcene Boumendjel , Chantal Beney , Nabajyoti Deka , Anne-Marie Mariotte
ChemInform, 2002, 33 (44), pp.no-no. ⟨10.1002/chin.200244127⟩
Journal articles hal-02331352v1

Re-evaluation of monosaccharide binding property of recombinant soluble carbohydrate recognition domain of the natural killer cell receptor NKR-P1A.

H. Kogelberg , E. Montero , S. Bay , A. M. Lawson , T. Feizi
Journal of Biological Chemistry, 1999, 274 (15), pp.30335-6
Journal articles pasteur-00167055v1

N,X-Acetals as Purinergic receptor P2RX7 ligands. Design and synthesis of N,S-backbones based on Morin rearrangement

Adam Daïch , Fanny Danton , Mohamed Othman , Ata Martin Lawson
Journée de l'école doctorale Normandie de Chimie JEDNC, Jun 2018, Le Havre, France
Conference papers hal-02567974v1

N,X Acetals : Ligands des récepteurs purinergiques P2X7

Adam Daïch , Fanny Danton , Mohamed Othman , Ata Martin Lawson
Journées Nord-Ouest Européennes des Jeunes Chercheurs, Jun 2018, Villeneuve d’Ascq, France
Conference papers hal-02568051v1

Preparation of (+) / (-)-gossypol Schiff base derivatives by SECheM methodology

Adam Daïch , Mohamed Vall Sidi Boune , Brahim Ould Elemine , Abderrahmane Ould Hadou , Ahmed Aliyenne
Journées André Collet de la Chiralité JACC, Sep 2018, Noirmoutier, France
Conference papers hal-02568053v1

New methodology for synthesis of Schiff base derivatives of (aR)/(aS)-gossypol

Adam Daïch , Mohamed Vall Sidi Boune , Brahim Elemine , Abderrahmane Ould Hadou , Mohamed Othman
Journée de l'école doctorale Normandie de Chimie JEDNC, Jun 2018, Le Havre, France
Conference papers hal-02567973v1

N,X-Acetals as Purinergic receptor P2X7 ligands. Design, synthesis and anti-cancer/anti-inflammatory evaluation

Adam Daïch , Fanny Danton , Mohamed Othman , Ata Martin Lawson
Journée de l'école doctorale Normandie de Chimie JEDNC, Jun 2017, Rouen, France
Conference papers hal-02567972v1

A Simultaneous Extraction and Chemical Modification Concept: Application for Gossypol Extraction and Semi-synthesis Directly from Cienfuegosia digitata

Adam Daïch , Mohamed Vall Sidi Boune , Brahim Elemine , Abderrahmane Ould Hadou , Mohamed Othman
Trends in Natural Product Research - PSE Young Scientists' Meeting Lille 2017, Natural Products in Health, Agro-Food and Cosmetics, Jun 2017, Lille, France
Conference papers hal-02568195v1

SECHEM Concept for Gossypol extraction and semi-synthesis directly from Cienfuegosia digitata

Adam Daïch , Mohamed Vall Sidi Boune , Brahim Elemine , Thomas Lepitre , Abderrahmane Ould Hadou
Journée de l'école doctorale Normandie de Chimie JEDNC, Jun 2017, Rouen, France
Conference papers hal-02567969v1

Original "one-pot" methodology combining extraction/chemical modification of gossypol from cienfuegosia digitata by traditional soxhlet system

Adam Daïch , Mohamed Vall Sidi Boune , Brahim Elemine , Abderrahmane Ould Hadou , Ahmed Aliyenne
Journées de Chimie Organique, Sep 2016, Palaiseau, France
Conference papers hal-02568193v1

Original Mitsunobu triggered sequence involved in a one-pot domino process

Adam Daïch , Thomas Lepitre , Ata Martin Lawson , Mohamed Othman
Journée de l'Ecole Doctorale Normande de Chimie, Jun 2016, Caen, France
Conference papers hal-02567967v1

Competitive intramolecular C-C vs. C-O bond coupling reactions through C6 ring-fused 2-pyridones synthesis

Adam Daïch , Thomas Lepitre , Ata Martin Lawson , Mohamed Othman
13th Anglo-Norman Organic Chemistry Colloquium (ANORCQ XIII), Apr 2016, Rouen, France
Conference papers hal-02568190v1

Original Mitsunobu triggered sequence involved in a one-pot domino process

Adam Daïch , Thomas Lepitre , Ata Martin Lawson , Mohamed Othman
Journées de Chimie Organique, Sep 2016, Palaiseau, France
Conference papers hal-02568191v1

Palladium Catalyzed Arylation vs Oxyarylation: Synthesis of C6 Ring-Fused Pyridones

Adam Daïch , Thomas Lepitre , Ata Martin Lawson , Mohamed Othman
Journées Nord-Ouest Européennes de Chimie (JNOEC), May 2015, Rouen, France
Conference papers hal-02568040v1

Design, Synthesis and Development of Novel Pathways to Functionalized Azaindole-based Derivatives with Anticancer and Anti-Angiogenic Activities

Adam Daïch , Vijaykumar D. Nimbarte , Ata Martin Lawson , Sébastien Comesse
IS:CE Chem and AI-Chem Channel Autumn School 2014, Sep 2014, Southampton, United Kingdom
Conference papers hal-02568189v1

New approaches for the synthesis and functionalization of 7- and 5-azaindoles as promising templates for medicinal chemistry

Adam Daïch , F Aubertein , Ata Martin Lawson , Sébastien Comesse
IS:CE Chem and AI-Chem Channel Autumn School 2014, Apr 2014, Southampton, United Kingdom
Conference papers hal-02568188v1

“Formation de liaisons C-C et/ou C-O intramoléculaire sur les 2-pyridones : synthèse d'hétérocycle d'intérêt

Adam Daïch , Catalin Pintiala , Ata Martin Lawson , Sébastien Comesse
Journées Nord-Ouest Européennes de Chimie (JNOEC), Jun 2013, Le Havre, France
Conference papers hal-02568038v1

New synthetic scalfolds through unexpected 1-6-Aza Michael addition to chromone derivatives : application to aromathecins analogues synthesis

Adam Daïch , Catalin Pintiala , Ata Martin Lawson , Sébastien Comesse
Colloque Franco-Roumain de Chimie Médicinale (CoFRROCM), Oct 2012, Lasi, Romania
Conference papers hal-02568184v1

1-6-Aza Michael addition to chromone derivatives and their application in the synthesis of aromathecin analogues

Adam Daïch , Catalin Pintiala , Ata Martin Lawson , Sébastien Comesse
11th Anglo-Norman Organic Chemistry Colloquium (ANORCQ XI), Apr 2012, Caen, France
Conference papers hal-02568183v1

Nouvelle voie d'accès à des bislactames de type Meyer par réaction Domino

Adam Daïch , Ronan Legoff , Ata Martin Lawson , Sébastien Comesse
Journées Nord-Ouest Européennes de Chimie (JNOEC), Jun 2012, Villeneuve d'Ascq, France
Conference papers hal-02568036v1

-unsaturated diester chromone in domino process based on a 1-6-Aza Michael addition”

Adam Daïch , Catalin Pintiala , Ata Martin Lawson , Sébastien Comesse
IS:CE CHEM Summer School, Jun 2011, Norwich, United Kingdom
Conference papers hal-02568182v1

Investigations on the Domino N-Amidoacylation/Aldol Type Condensation for the Synthesis of the Bioactive Aromathecins and Analogs

Adam Daïch , A Anamoune , Ata Martin Lawson , Sébastien Comesse
Ninth Anglo-Normand Organic Chemistry Colloquium -ANORCQ X-, Apr 2010, Southampton, United Kingdom
Conference papers hal-02568177v1

Investigations on the Domino N-Amidoacylation/Aldol Type Condensation for the Synthesis of the Bioactive Aromathecins and Analogs

Adam Daïch , A Anamoune , Ata Martin Lawson , Sébastien Comesse
Journée de l'École Doctorale Normande de Chimie, Haute Normandie, Jun 2010, Caen, France
Conference papers hal-02567961v1