Badreddine Douzi

Badreddine Douzi
56
Documents

Présentation

Domaines de recherche

Biologie structurale [q-bio.BM] Biochimie [q-bio.BM] Biologie moléculaire

Publications

6
6
4
4
4
4
4
3
3
3
3
3
3
3
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
20
17
16
14
8
8
7
7
6
6
6
5
5
4
4
4
4
3
3
3
3
3
3
3
3
3
3
3
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
6
4
3
2
2
2
2
2
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
3
1
3
4
3
3
1
5
4
4
3
6
3
2
6
2
2
5
5
4
3
2
2
2
1
1
28
11
3
3
3
2
2
1
1
1
1
1
1
17
15
7
4
2
2
2
1
1

Publications

Deposit thumbnail

Co-option of an ancestral peptidase controls developmental patterning in multicellular cyanobacteria

Xiaomei Xu , Anaïs Scholivet , Stéphanie Champ , Matthieu Bergé , Zulihumaer Yeerkenjiang et al.

iScience, 2026, 29 (1), pp.114265. ⟨10.1016/j.isci.2025.114265⟩

Article dans une revue hal-05457710v1
Deposit thumbnail

Elucidating assembly and function of VirB8 cell wall subunits refines the DNA translocation model in Gram-positive T4SSs

Robine Maffo-Woulefack , Abbas Mohamad Ali , Haifa Laroussi , Julien Cappele , Felipe Romero-Saavedra et al.

Science Advances , 2025, 11 (4), pp.eadq5975. ⟨10.1126/sciadv.adq5975⟩

Article dans une revue hal-04916057v1
Deposit thumbnail

Massive acquisition of conjugative and mobilizable integrated elements fuels Faecalibacterium plasticity and hints at their adaptation to the gut

Gérard Guédon , Florence Charron-Bourgoin , Thomas Lacroix , Toufik Hamadouche , Nicolas Soler et al.

Scientific Reports, 2025, 15 (1), pp.17013. ⟨10.1038/s41598-025-99981-y⟩

Article dans une revue hal-05397378v1
Deposit thumbnail

Two OB-fold proteins from a Gram-positive conjugative element engage in relaxosome assembly and DNA processing

Haifa Laroussi , Robine Maffo-Woulefack , Julien Cappèle , Hicham Sekkouri Alaoui , Lysiane Lessure et al.

Nucleic Acids Research, 2025, 53 (21), pp.gkaf1161. ⟨10.1093/nar/gkaf1161⟩

Article dans une revue hal-05445247v1
Deposit thumbnail

Unravelling HetC as a peptidase-based ABC exporter driving functional cell differentiation in the cyanobacterium Nostoc PCC 7120

Raphaël Rachedi , Véronique Risoul , Maryline Foglino , Yanis Aoudache , Kevin Lang et al.

Microbiology Spectrum, 2024, 12 (4), ⟨10.1128/spectrum.04058-23⟩

Article dans une revue hal-04539483v1
Deposit thumbnail

Insights into dynamics and gating properties of T2SS secretins

Brice Barbat , Badreddine Douzi , Geneviève Ball , Mathilde Tribout , Khalid El Karkouri et al.

Science Advances , 2023, 9 (40), ⟨10.1126/sciadv.adg6996⟩

Article dans une revue hal-04254401v1

Refining the Dynamic Network of T2SS Endopilus Tip Heterocomplex Combining cw‐EPR and Nitroxide–Gd III Distance Measurements

Guillaume Gerbaud , Brice Barbat , Mathilde Tribout , Emilien Etienne , Valérie Belle et al.

ChemBioChem, 2023, 24 (15), ⟨10.1002/cbic.202300099⟩

Article dans une revue hal-04210232v1

A new twin expands the VirB8-like protein family

Robine Maffo-Woulefack , Nathalie N. Leblond-Bourget , Badreddine Douzi

Structure, 2022, 30 (6), pp.790-792. ⟨10.1016/j.str.2022.05.004⟩

Article dans une revue hal-03994713v1
Deposit thumbnail

The crystal structure of CbpD clarifies substrate-specificity motifs in chitin-active lytic polysaccharide monooxygenases

Christopher Dade , Badreddine Douzi , Christian Cambillau , Genevieve Ball , Romé Voulhoux et al.

Acta crystallographica Section D : Structural biology [1993-..], 2022, 78 (8), pp.1064-1078. ⟨10.1107/S2059798322007033⟩

Article dans une revue hal-03739502v1
Deposit thumbnail

Structural lessons on bacterial secretins

Brice Barbat , Badreddine Douzi , Romé Voulhoux

Biochimie, 2022, 205, pp.110-116. ⟨10.1016/j.biochi.2022.08.019⟩

Article dans une revue hal-03845257v1
Deposit thumbnail

Exploration of DNA processing features unravels novel properties of ICE conjugation in Gram-positive bacteria

Haifa Laroussi , Yanis Aoudache , Emilie Robert , Virginie Libante , Louise Thiriet et al.

Nucleic Acids Research, 2022, 50 (14), pp.8127-8142. ⟨10.1093/nar/gkac607⟩

Article dans une revue hal-03881644v1
Deposit thumbnail

Structural and Biochemical Analysis of OrfG: The VirB8-like Component of the Conjugative Type IV Secretion System of ICESt3 From Streptococcus thermophilus

Julien Cappele , Abbas Mohamad Ali , Nathalie N. Leblond-Bourget , Sandrine Mathiot , Tiphaine Dhalleine et al.

Frontiers in Molecular Biosciences, 2021, 8, ⟨10.3389/fmolb.2021.642606⟩

Article dans une revue hal-03196531v1
Deposit thumbnail

Structural interactions define assembly adapter function of a type II secretion system pseudopilin

Cristian Escobar , Badreddine Douzi , Geneviève Ball , Brice Barbat , Sebastien Alphonse et al.

Structure, 2021, 29 (10), pp.1116-1127.e8. ⟨10.1016/j.str.2021.05.015⟩

Article dans une revue hal-03367306v1
Deposit thumbnail

HetL, HetR and PatS form a reaction-diffusion system to control pattern formation in the cyanobacterium Nostoc PCC 7120

Xiaomei Xu , Véronique Risoul , Deborah Byrne , Stéphanie M Champ , Badreddine Douzi et al.

eLife, 2020, 9, ⟨10.7554/eLife.59190⟩

Article dans une revue hal-02917356v1
Deposit thumbnail

YtfK activates the stringent response by triggering the alarmone synthetase SpoT in Escherichia coli

Elsa Germain , Paul Guiraud , Deborah Byrne , Badreddine Douzi , Meriem Djendli et al.

Nature Communications, 2019, 10 (1), ⟨10.1038/s41467-019-13764-4⟩

Article dans une revue hal-02446175v1
Deposit thumbnail

Structure–Function Analysis of the C-Terminal Domain of the Type VI Secretion TssB Tail Sheath Subunit

Badreddine Douzi , Laureen Logger , Silvia Spinelli , Stephanie Blangy , Christian Cambillau et al.

Journal of Molecular Biology, 2018, 430 (3), pp.297 - 309. ⟨10.1016/j.jmb.2017.11.015⟩

Article dans une revue hal-01780748v1
Deposit thumbnail

The gp27-like Hub of VgrG Serves as Adaptor to Promote Hcp Tube Assembly

Melvin G Renault , Jordi Zamarreño Beas , Badreddine Douzi , Maïalène Chabalier , Abdelrahim Zoued et al.

Journal of Molecular Biology, 2018, 430 (18 Pt B), pp.3143-3156. ⟨10.1016/j.jmb.2018.07.018⟩

Article dans une revue hal-01847145v1
Deposit thumbnail

Towards a complete structural deciphering of Type VI secretion system

van Son Nguyen , Badreddine Douzi , Eric Durand , Alain Roussel , E. Cascales et al.

Current Opinion in Structural Biology, 2018, 49, pp.77 - 84. ⟨10.1016/j.sbi.2018.01.007⟩

Article dans une revue hal-01780753v1
Deposit thumbnail

Direct interactions between the secreted effector and the T2SS components GspL and GspM reveal a new effector-sensing step during type 2 secretion

Sandra Michel-Souzy , Badreddine Douzi , Frederic Cadoret , Claire Raynaud , Loïc Quinton et al.

Journal of Biological Chemistry, 2018, 293 (50), pp.19441-19450. ⟨10.1074/jbc.RA117.001127⟩

Article dans une revue hal-01919531v1
Deposit thumbnail

Unraveling the Self-Assembly of the Pseudomonas aeruginosa XcpQ Secretin Periplasmic Domain Provides New Molecular Insights into Type II Secretion System Secreton Architecture and Dynamics

Badreddine Douzi , Nhung Trinh , Sandra Michel-Souzy , Aline Desmyter , Genevieve Ball et al.

mBio, 2017, 8 (5), ⟨10.1128/mBio.01185-17⟩

Article dans une revue hal-01744494v1
Deposit thumbnail

Structure–Function Analysis of the TssL Cytoplasmic Domain Reveals a New Interaction between the Type VI Secretion Baseplate and Membrane Complexes

Abdelrahim Zoued , Chloé J Cassaro , Eric Durand , Badreddine Douzi , Alexandre España et al.

Journal of Molecular Biology, 2016, 428 (22), pp.4413 - 4423. ⟨10.1016/j.jmb.2016.08.030⟩

Article dans une revue hal-01780163v1
Deposit thumbnail

Structure and specificity of the Type VI secretion system ClpV-TssC interaction in enteroaggregative Escherichia coli

Badreddine Douzi , Yannick R Brunet , Silvia Spinelli , Valentine Lensi , Stephanie Blangy et al.

Scientific Reports, 2016, 6 (1), ⟨10.1038/srep34405⟩

Article dans une revue hal-01780690v1
Deposit thumbnail

Priming and polymerization of a bacterial contractile tail structure. 1" 2" 17

Abdelrahim Zoued , Eric Durand , Yannick R Brunet , Silvia Spinelli , Badreddine Douzi et al.

Nature, 2016, 531 (7592), pp.59 - 63. ⟨10.1038/nature17182⟩

Article dans une revue hal-01778575v1
Deposit thumbnail

The Type VI Secretion TssEFGK-VgrG Phage-Like Baseplate Is Recruited to the TssJLM Membrane Complex via Multiple Contacts and Serves As Assembly Platform for Tail Tube/Sheath Polymerization

Yannick R Brunet , Abdelrahim Zoued , Frédéric Boyer , Badreddine Douzi , E. Cascales

PLoS Genetics, 2015, 11 (10), pp.e1005545. ⟨10.1371/journal.pgen.1005545⟩

Article dans une revue hal-01458191v1
Deposit thumbnail

Inhibition of Type VI Secretion by an Anti-TssM Llama Nanobody

van Son Nguyen , Laureen Logger , Silvia Spinelli , Aline Desmyter , Thi Thu Hang Le et al.

PLoS ONE, 2015, 10 (e0122187), pp.1-14

Article dans une revue hal-01217205v1

Architecture and assembly of the Type VI secretion system.

Abdelrahim Zoued , Yannick R Brunet , Eric Durand , Marie-Stéphanie Aschtgen , Laureen Logger et al.

Biochim. Biophys. Acta, 2014, 1843 (8), pp.1664--73. ⟨10.1016/j.bbamcr.2014.03.018⟩

Article dans une revue hal-01458220v1
Deposit thumbnail

Crystal Structure and Self-Interaction of the Type VI Secretion Tail-Tube Protein from Enteroaggregative Escherichia coli

Badreddine Douzi , Silvia Spinelli , Stéphanie Blangy , Alain Roussel , Eric Durand et al.

PLoS ONE, 2014, 9 (2), pp.e86918. ⟨10.1371/journal.pone.0086918⟩

Article dans une revue hal-02091448v1
Deposit thumbnail

Crystal Structure and Self-Interaction of the Type VI Secretion Tail-Tube Protein from Enteroaggregative Escherichia coli

Badreddine Douzi , Silvia Spinelli , Stéphanie Blangy , Alain Roussel , Eric Durand et al.

PLoS ONE, 2014, 9 (2), pp.e86918. ⟨10.1371/journal.pone.0086918⟩

Article dans une revue hal-03274780v1

Txc, a new type II secretion system of Pseudomonas aeruginosa strain PA7, is regulated by the TtsS/TtsR two-component system and directs specific secretion of the CbpE chitin-binding protein.

Frederic Cadoret , Geneviève Ball , Badreddine Douzi , Romé Voulhoux

Journal of Bacteriology, 2014, 196 (13), pp.2376--86. ⟨10.1128/JB.01563-14⟩

Article dans une revue hal-01458218v1

Architecture and assembly of the Type VI secretion system

Abdelrahim Zoued , Yannick Brunet , Eric Durand , Marie-Stéphanie Aschtgen , Laureen Logger et al.

Biochimica et Biophysica Acta - Molecular Cell Research, 2014, 1843 (8), pp.1664-1673. ⟨10.1016/j.bbamcr.2014.03.018⟩

Article dans une revue hal-03274779v1
Deposit thumbnail

TssK Is a Trimeric Cytoplasmic Protein Interacting with Components of Both Phage-like and Membrane Anchoring Complexes of the Type VI Secretion System

Abdelrahim Zoued , Eric Durand , Cecilia C. Bebeacua , Yannick R Brunet , Badreddine Douzi et al.

Journal of Biological Chemistry, 2013, 288 (38), pp.27031-27041. ⟨10.1074/jbc.M113.499772⟩

Article dans une revue hal-02091435v1
Deposit thumbnail

Dissection of the TssB-TssC Interface during Type VI Secretion Sheath Complex Formation

Xiang Y. Zhang , Yannick R Brunet , Laureen Logger , Badreddine Douzi , Christian Cambillau et al.

PLoS ONE, 2013, 8 (11), pp.e81074. ⟨10.1371/journal.pone.0081074⟩

Article dans une revue hal-02091436v1
Deposit thumbnail

High throughput screening identifies disulfide isomerase DsbC as a very efficient partner for recombinant expression of small disulfide-rich proteins in E. coli

Hervé Nozach , Carole Fruchart-Gaillard , François Fenaille , Fabrice Beau , Oscar Pereira Ramos et al.

Microbial Cell Factories, 2013, 12, ⟨10.1186/1475-2859-12-37⟩

Article dans une revue cea-02100032v1

On the path to uncover the bacterial type II secretion system.

Badreddine Douzi , Alain Filloux , Romé Voulhoux

Philos. Trans. R. Soc. Lond., B, Biol. Sci., 2012, 367 (1592), pp.1059--72. ⟨10.1098/rstb.2011.0204⟩

Article dans une revue hal-01458255v1
Deposit thumbnail

Towards a structural comprehension of bacterial type VI secretion systems: characterization of the TssJ-TssM complex of an Escherichia coli pathovar

Catarina Felisberto-Rodrigues , Eric Durand , Marie-Stéphanie Aschtgen , Stephanie Blangy , Miguel Ortiz-Lombardia et al.

PLoS Pathogens, 2011, 7 (11), pp.e1002386. ⟨10.1371/journal.ppat.1002386⟩

Article dans une revue hal-01458272v1

Structure of the minor pseudopilin XcpW from the Pseudomonas aeruginosa type II secretion system.

Laura P Franz , Badreddine Douzi , Eric Durand , David H Dyer , Romé Voulhoux et al.

Acta Crystallogr. D Biol. Crystallogr., 2011, 67 (Pt 2), pp.124--30. ⟨10.1107/S0907444910051954⟩

Article dans une revue hal-01458266v1

Deciphering the Xcp Pseudomonas aeruginosa type II secretion machinery through multiple interactions with substrates.

Badreddine Douzi , Geneviève Ball , Christian Cambillau , Mariella Tegoni , Romé Voulhoux

Journal of Biological Chemistry, 2011, 286 (47), pp.40792--801. ⟨10.1074/jbc.M111.294843⟩

Article dans une revue hal-01458270v1

Towards a Structural Comprehension of Bacterial Type VI Secretion Systems: Characterization of the TssJ-TssM Complex of an Escherichia coli Pathovar

Catarina Felisberto-Rodrigues , Eric Durand , Marie-Stéphanie Aschtgen , Stéphanie Blangy , Miguel Ortiz-Lombardia et al.

PLoS Pathogens, 2011, 7 (11), pp.e1002386. ⟨10.1371/journal.ppat.1002386⟩

Article dans une revue hal-03274802v1

The Assembly Mode of the Pseudopilus: a hallmark to distinguish a novel secretion system subtype

E. Durand , S. Alphonse , Céline Brochier-Armanet , G. Ball , Badreddine Douzi et al.

Journal of Biological Chemistry, 2011, 286 (27), pp.24407-24416. ⟨10.1074/jbc.M111.234278⟩

Article dans une revue hal-02299276v1
Deposit thumbnail

D-Maurocalcine, a pharmacologically inert efficient cell-penetrating peptide analogue.

Cathy Poillot , Kaouthar Dridi , Hicham Bichraoui , Julien Pêcher , Sébastien Alphonse et al.

Journal of Biological Chemistry, 2010, 285 (44), pp.34168-80. ⟨10.1074/jbc.M110.104919⟩

Article dans une revue inserm-00587800v1

Structure of the Pseudomonas aeruginosa XcpT pseudopilin, a major component of the type II secretion system

S. Alphonse , E. Durand , Badreddine Douzi , B. Waegele , H. Darbon et al.

Journal of Structural Biology, 2010, 169 (1), pp.75-80. ⟨10.1016/j.jsb.2009.09.003⟩

Article dans une revue hal-02667520v1

The XcpV/GspI pseudopilin has a central role in the assembly of a quaternary complex within the T2SS pseudopilus

Badreddine Douzi , E. Durand , C. Bernard , S. Alphonse , C. Cambillau et al.

Journal of Biological Chemistry, 2009, 284 (50), pp.34580-34589. ⟨10.1074/jbc.M109.042366⟩

Article dans une revue hal-02666049v1

Protein-Protein Interactions: Surface Plasmon Resonance

Badreddine Douzi

Bacterial Protein Secretion Systems : Methods and Protocols, Springer Link, 2017, Methods in Molecular Biology, 978-1-4939-7033-9 978-1-4939-7031-5. ⟨10.1007/978-1-4939-7033-9_21⟩

Chapitre d'ouvrage hal-02790765v1