Bruno Ségui

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TNF signature in advanced melanoma patients treated with immune checkpoint inhibitors: Results from the MELANFα clinical study

Mathieu Virazels , Amélie Lusque , Stéphanie Brayer , Matthieu Genais , Carine Dufau et al.
International Journal of Cancer, 2025, ⟨10.1002/ijc.35416⟩
Article dans une revue (data paper) hal-04996473 v1
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Ceramide metabolism alterations contribute to Tumor Necrosis Factor-induced melanoma dedifferentiation and predict resistance to immune checkpoint inhibitors in advanced melanoma patients

Carine Dufau , Matthieu Genais , Elodie Mucher , Benjamin Jung , Virginie Garcia et al.
Frontiers in Immunology, 2024, 15, pp.1421432. ⟨10.3389/fimmu.2024.1421432⟩
Article dans une revue inserm-04773877 v1

A fluorogenic substrate for the detection of lipid amidases in intact cells

Mireia Casasampere , Johnson Ung , Alejandro Iñáñez , Carine Dufau , Kazuhito Tsuboi et al.
Journal of Lipid Research, 2024, 65 (3), pp.100520. ⟨10.1016/J.JLR.2024.100520⟩
Article dans une revue inserm-04873248 v1
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Sphingolipid paracrine signaling impairs keratinocyte adhesion to promote melanoma invasion

Justine Noujarède , Lorry Carrié , Virginie Garcia , Maxime Grimont , Anaïs Eberhardt et al.
Cell Reports, 2023, 42 (12), pp.113586. ⟨10.1016/j.celrep.2023.113586⟩
Article dans une revue hal-04374455 v1
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Neutral Sphingomyelinase 2 Heightens Anti-Melanoma Immune Responses and Anti–PD-1 Therapy Efficacy

Anne Montfort , Florie Bertrand , Julia Rochotte , Julia Gilhodes , Thomas Filleron et al.
Cancer Immunology Research, 2021, 9 (5), pp.568-582. ⟨10.1158/2326-6066.CIR-20-0342⟩
Article dans une revue inserm-03402255 v1

Combining TNF blockade with immune checkpoint inhibitors in patients with cancer

Anne Montfort , Mathieu Virazels , Céline Colacios , Nicolas Meyer , Bruno Ségui
Nature Reviews Rheumatology, 2021, 17 (9), pp.577-577. ⟨10.1038/s41584-021-00653-8⟩
Article dans une revue (article de synthèse) hal-04960542 v1

Thrombospondin-1 Silencing Improves Lymphocyte Infiltration in Tumors and Response to Anti-PD-1 in Triple-Negative Breast Cancer

Elie Marcheteau , Thomas Farge , Michaël Pérès , Guillaume Labrousse , Julie Tenet et al.
Cancers, 2021, 13 (16), pp.4059. ⟨10.3390/cancers13164059⟩
Article dans une revue hal-05033645 v1
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Resistance of melanoma to immune checkpoint inhibitors is overcome by targeting the sphingosine kinase-1

Caroline Imbert , Anne Montfort , Marine Fraisse , Elie Marcheteau , Julia Gilhodes et al.
Nature Communications, 2020, 11 (1), pp.437. ⟨10.1038/s41467-019-14218-7⟩
Article dans une revue inserm-02492179 v1
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Lipid metabolic Reprogramming: Role in Melanoma Progression and Therapeutic Perspectives

Laurence Pellerin , Lorry Carrié , Carine Dufau , Laurence Nieto , Bruno Ségui et al.
Cancers, 2020, 12 (11), pp.3147. ⟨10.3390/cancers12113147⟩
Article dans une revue hal-03020981 v1
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New Insights into the Role of Sphingolipid Metabolism in Melanoma

Lorry Carrié , Mathieu Virazels , Carine Dufau , Anne Montfort , Thierry Levade et al.
Cells, 2020, 9 (9), pp.1967. ⟨10.3390/cells9091967⟩
Article dans une revue inserm-04873888 v1
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Lipid metabolic Reprogramming: Role in Melanoma Progression and Therapeutic Perspectives

Laurence Pellerin , Lorry Carrié , Carine Dufau , Laurence Nieto , Bruno Ségui et al.
Cancers, 2020, 12 (11), pp.3147. ⟨10.3390/cancers12113147⟩
Article dans une revue inserm-04873868 v1

Targeting the Sphingosine 1-Phosphate Axis Exerts Potent Antitumor Activity in BRAFi-Resistant Melanomas

David Garandeau , Justine Noujarède , Justine Leclerc , Caroline Imbert , Virginie Garcia et al.
Molecular Cancer Therapeutics, 2019, 18 (2), pp.289-300. ⟨10.1158/1535-7163.MCT-17-1141⟩
Article dans une revue hal-03194448 v1

IL13-Mediated Dectin-1 and Mannose Receptor Overexpression Promotes Macrophage Antitumor Activities through Recognition of Sialylated Tumor Cells

Mohammad Alaeddine , Mélissa Prat , Verena Poinsot , Valérie Gouazé-Andersson , Hélène Authier et al.
Cancer Immunology Research, 2019, ⟨10.1158/2326-6066.CIR-18-0213⟩
Article dans une revue hal-02194445 v1
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Morniga-G, a T/Tn-Specific Lectin, Induces Leukemic Cell Death via Caspase and DR5 Receptor-Dependent Pathways

Guillaume Poiroux , Annick Barre , Mathias Simplicien , Sandrine Pelofy , Bruno Segui et al.
International Journal of Molecular Sciences, 2019, 20 (1), pp.230. ⟨10.3390/ijms20010230⟩
Article dans une revue hal-03350717 v1
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The TNF Paradox in Cancer Progression and Immunotherapy

Anne Montfort , Céline Colacios , Thierry Levade , Nathalie Andrieu-Abadie , Nicolas Meyer et al.
Frontiers in Immunology, 2019, 10, pp.1818. ⟨10.3389/fimmu.2019.01818⟩
Article dans une revue inserm-04905614 v1
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Anti-TNF, a magic bullet in cancer immunotherapy?

Anne Montfort , Carine Dufau , Céline Colacios , Nathalie Andrieu-Abadie , Thierry Levade et al.
Journal for Immunotherapy of Cancer, 2019, 7 (1), pp.303. ⟨10.1186/s40425-019-0802-y⟩
Article dans une revue inserm-04905685 v1
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Sphingomyelin Synthase 1 (SMS1) Downregulation Is Associated With Sphingolipid Reprogramming and a Worse Prognosis in Melanoma

Fatima Bilal , Anne Montfort , Julia Gilhodes , Virginie Garcia , Joelle Riond et al.
Frontiers in Pharmacology, 2019, 10, pp.443. ⟨10.3389/fphar.2019.00443⟩
Article dans une revue hal-02332278 v1
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Les anticorps anti-TNFα dans l’immunothérapie du mélanome

Anne Montfort , Céline Colacios , Thierry Levade , Nathalie Andrieu-Abadie , Nicolas Meyer et al.
Médecine/Sciences, 2018, 34 (10), pp.788 - 791. ⟨10.1051/medsci/2018202⟩
Article dans une revue inserm-04905584 v1
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TNFα blockade overcomes resistance to anti-PD-1 in experimental melanoma

Florie Bertrand , Anne Montfort , Elie Marcheteau , Caroline Imbert , Julia Gilhodes et al.
Nature Communications, 2017, 8 (1), pp.2256. ⟨10.1038/s41467-017-02358-7⟩
Article dans une revue inserm-04905428 v1
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S1P: the elixir of life for naive T cells

Michaël Pérès , Anne Montfort , Nathalie Andrieu-Abadie , Céline Colacios , Bruno Ségui
Cellular and molecular immunology, 2017, 15 (7), pp.657 - 659. ⟨10.1038/cmi.2017.110⟩
Article dans une revue inserm-04905494 v1
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TNFα blockade overcomes resistance to anti-PD-1 in experimental melanoma

Florie Bertrand , Anne Montfort , Elie Marcheteau , Caroline Imbert , Julia Gilhodes et al.
Nature Communications, 2017, 8 (1), ⟨10.1038/s41467-017-02358-7⟩
Article dans une revue hal-04866756 v1

Downregulation of ceramide synthase-6 during epithelial-to-mesenchymal transition reduces plasma membrane fluidity and cancer cell motility

Valérie Edmond , Florent Dufour , Guillaume Poiroux , Kenji Shoji , Marine Malleter et al.
Oncogene, 2015, 34 (8), pp.996-1005. ⟨10.1038/onc.2014.55⟩
Article dans une revue hal-01063558 v1
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Chemotherapy with ceramide in TNBC

Patrick Legembre , Olivier Micheau , Bruno Ségui
Oncoscience, 2015, 2 (10), pp.817--818. ⟨10.18632/oncoscience.196⟩
Article dans une revue hal-01255869 v1
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Monogenic neurological disorders of sphingolipid metabolism

Frédérique Sabourdy , Leonardo Astudillo , Céline Colacios , Patricia Dubot , Marguerite Mrad et al.
Biochimica et Biophysica Acta Molecular and Cell Biology of Lipids, 2015, 1851 (8), pp.1040 - 1051. ⟨10.1016/j.bbalip.2015.01.010⟩
Article dans une revue inserm-04906477 v1

CD95 triggers Orai1-mediated localized Ca2+ entry, regulates recruitment of protein kinase C (PKC) β2, and prevents death-inducing signaling complex formation.

Nadine Khadra , Laurence Bresson-Bepoldin , Aubin Penna , Benjamin Chaigne-Delalande , Bruno Ségui et al.
Proceedings of the National Academy of Sciences of the United States of America, 2011, 108 (47), pp.19072-7. ⟨10.1073/pnas.1116946108⟩
Article dans une revue inserm-00641268 v1

Apolipoprotein E-deficient mice develop an anti-Chlamydophila pneumoniae T helper 2 response and resist vascular infection.

Dani Nazzal , Nicole Therville , Houda Yacoub-Youssef , Virginie Garcia , Mogens Thomsen et al.
Journal of Infectious Diseases, 2010, 202 (5), pp.782-90. ⟨10.1086/655700⟩
Article dans une revue inserm-00613672 v1

Caspase-mediated inhibition of sphingomyelin synthesis is involved in FasL-triggered cell death.

Elodie Lafont , Delphine Milhas , Stéphane Carpentier , Virgine Garcia , Z.-X. Jin et al.
Cell Death and Differentiation, 2010, 17 (4), pp.642-54. ⟨10.1038/cdd.2009.130⟩
Article dans une revue inserm-00473914 v1
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Caspase-10-dependent cell death in Fas/CD95 signalling is not abrogated by caspase inhibitor zVAD-fmk.

Elodie Lafont , Delphine Milhas , Justin Teissié , Nicole Therville , Nathalie Andrieu-Abadie et al.
PLoS ONE, 2010, 5 (10), pp.e13638. ⟨10.1371/journal.pone.0013638⟩
Article dans une revue inserm-00550848 v1

FAN (factor associated with neutral sphingomyelinase activation), a moonlighting protein in TNF-R1 signaling.

Anne Montfort , Pascal G.P. Martin , Thierry Levade , Hervé Benoist , Bruno Ségui
Journal of Leukocyte Biology, 2010, 88 (5), epub ahead of print. ⟨10.1189/jlb.0410188⟩
Article dans une revue inserm-00504725 v1

Two structurally identical mannose-specific jacalin-related lectins display different effects on human T lymphocyte activation and cell death.

Hervé Benoist , Raphael Culerrier , Guillaume Poiroux , Bruno Ségui , Alain Jauneau et al.
Journal of Leukocyte Biology, 2009, 86 (1), pp.103-14. ⟨10.1189/jlb.0708434⟩
Article dans une revue inserm-00409940 v1

Interleukin-6 deficiency fails to prevent chronic rejection after aortic allografts in apolipoprotein E-deficient mice.

Houda Yacoub-Youssef , Nelly Blaes , Denis Calise , Jean Claude Thiers , Nicole Therville et al.
The Journal of Heart and Lung Transplantation, 2009, 28 (1), pp.85-92. ⟨10.1016/j.healun.2008.06.012⟩
Article dans une revue inserm-00423309 v1
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IL-6 deficiency attenuates murine diet-induced non-alcoholic steatohepatitis.

Emmanuel Mas , Marie Danjoux , Virginie Garcia , Stéphane Carpentier , Bruno Ségui et al.
PLoS ONE, 2009, 4 (11), pp.e7929. ⟨10.1371/journal.pone.0007929⟩
Article dans une revue inserm-00474274 v1

FAN stimulates TNF(alpha)-induced gene expression, leukocyte recruitment, and humoral response.

Anne Montfort , Bénédicte de Badts , Victorine Douin-Echinard , Pascal G.P. Martin , Jason S. Iacovoni et al.
Journal of Immunology, 2009, 183 (8), pp.5369-78. ⟨10.4049/jimmunol.0803384⟩
Article dans une revue inserm-00473894 v1
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OPA1 cleavage depends on decreased mitochondrial ATP level and bivalent metals.

Laurent Baricault , Bruno Ségui , Laurie Guégand , Aurélien Olichon , Annie Valette et al.
Experimental Cell Research, 2007, 313 (17), pp.3800-8. ⟨10.1016/j.yexcr.2007.08.008⟩
Article dans une revue inserm-00174981 v1

Cleavage and cytoplasmic relocalization of histone deacetylase 3 are important for apoptosis progression.

Fabrice Escaffit , Olivier Vaute , Martine Chevillard-Briet , Bruno Segui , Yasunari Takami et al.
Molecular and Cellular Biology, 2007, 27 (2), pp.554-67. ⟨10.1128/MCB.00869-06⟩
Article dans une revue hal-00317862 v1

Lysosomal sphingomyelinase is not solicited for apoptosis signaling

Christine Bezombes , Bruno Ségui , Olivier Cuvillier , Alain Bruno , Emmanuelle Uro-Coste et al.
FASEB Journal, 2000, 15 (2), pp.297-299. ⟨10.1096/fj.00-0466fje⟩
Article dans une revue inserm-04826847 v1

Anti-TNF in melanoma immunotherapy: from basic research to early clinical trials in advanced melanoma patients

Bruno Ségui
Summer school on Medicines, Vitor Faça, Jun 2024, Ribeirão Preto, Brazil
Communication dans un congrès hal-04991577 v1

Targeting ceramide metabolism in melanoma to improve the efficacy of immune checkpoint inhibitor therapy: from basic mechanisms to the clinic.

Bruno Ségui , Carine Dufau , Benjamin Jung , Matthieu Genais , Thierry Levade et al.
XV SPHINGOLIPID CLUB MEETING, Sep 2024, Erlangen-Nürnberg, Germany
Communication dans un congrès hal-04974692 v1

Anti-TNF in melanoma therapy: from basic research to early clinical trials in advanced melanoma patients.

Bruno Ségui
Summer School on Medicines, Marçal Pastor-Anglada, Jul 2023, Barcelona (ES), Spain
Communication dans un congrès hal-04991531 v1

Triple combination of anti-CTLA-4, anti-PD-1 and anti-TNF in mouse melanoma models and advanced melanoma patients.

Bruno Ségui , Anne Montfort , Mathieu Virazels , Matthieu Genais , Amélie Lusque et al.
EACR conferences “Defence is the Best Attack: Immuno-Oncology Breakthroughs”, Joan Seoane, May 2023, Barcelona, Spain
Communication dans un congrès hal-04974544 v1

Ceramide metabolism alterations contribute to Tumor Necrosis Factor-induced melanoma dedifferentiation.

Bruno Ségui , Carine Dufau , Matthieu Genais , Elodie Mucher , Benjamin Jung et al.
International Ceramide Conference, Apr 2023, Charleston, South Carolina, United States
Communication dans un congrès hal-04974508 v1

Ceramide metabolism alterations contribute to Tumor Necrosis Factor-induced melanoma dedifferentiation: from basic research to immunotherapy in advanced melanoma patients.

Bruno Ségui , Carine Dufau , Matthieu Genais , Elodie Mucher , Benjamin Jung et al.
FEBS Sphingolipid biology, Oct 2023, Funchal (Madeira Island), Portugal
Communication dans un congrès hal-04974669 v1

Anti-TNF in melanoma immunotherapy: from basic findings to the clinic.

Bruno Ségui
10èmes Journée d’Immunologie et Immunothérapie des Cancers (JIIC), Ali Bettaieb, Dec 2022, Dijon, France
Communication dans un congrès hal-04974429 v1

Ceramide metabolism in melanoma: from basic mechanisms to immunotherapy in advanced melanoma patients.

Bruno Ségui
ESMED general assembly, Aug 2022, Madrid (Online Only), Spain
Communication dans un congrès hal-04974455 v1

Early phase clinical trial in melanoma: a repositioning venture

Bruno Ségui
The 12th Summer School on Medicines, Pierre Cordelier, Jul 2022, Toulouse, France
Communication dans un congrès hal-04975301 v1

Anti-TNF in melanoma immunotherapy: from basic findings to the clinic

Bruno Ségui
Melanoma Workshop 2021, C. BERTOLOTTO and R. BALLOTTI, Aug 2021, Nice, France
Communication dans un congrès hal-04974420 v1

Anti-TNF + Nivolumab + Ipilimumab pour le traitement du mélanome avancé : premiers résultats de l’essai clinique TICIMEL

Anne Montfort , Thomas Filleron , Mathieu Virazels , Bruno Ségui , Nicolas Meyer
Journées dermatologiques de Paris, Nov 2021, Paris, France
Communication dans un congrès hal-04970832 v1

Combining TNF inhibitors to anti-PD-1 and anti-CTLA-4 for the treatment of advanced melanoma patients

Anne Montfort , Mathieu Virazels , Carine Dufau , Stéphanie Brayer , Nathalie Andrieu-Abadie et al.
17ème journées du Cancéropôle Grand Sud-Ouest, Nov 2021, Carcassone, France
Communication dans un congrès hal-04970934 v1

Neutral sphingomyelinase 2 heightens anti-melanoma immune responses and anti-PD-1 therapy efficacy.

Bruno Ségui
The 141st Annual Meeting of the Pharmaceutical Society of Japan, Pharmaceutical Society of Japan, Mar 2021, Hiroshima (Virtual meeting), Japan
Communication dans un congrès hal-04974402 v1

Neutral sphingomyelinase 2 heightens anti-melanoma immune response and synergizes with anti-PD-1.

Anne Montfort , Florie Bertrand , Julia Rochotte , Nathalie Andrieu-Abadie , Thierry Levade et al.
Toulouse Oncoweek, Feb 2020, Toulouse, France
Communication dans un congrès hal-04971026 v1

Ceramide metabolism in melanoma: From basic mechanisms to Immunotherapy in advanced melanoma patients.

Bruno Ségui
Introduction lecture at the 14th Sphingo Therapy Conference, Toshiro Okazaki, Jan 2020, Kanazawa, Japan
Communication dans un congrès hal-04974371 v1

Ceramide metabolism in melanoma: from basic mechanisms to immunotherapy in advanced melanoma patients.

Bruno Ségui , Anne Montfort , Caroline Imbert , Céline Colacios , Nathalie Andrieu-Abadie et al.
FEBS 2019 Sphingolipid Biology: Sphingolipids in Physiology and Pathology, Giovanni D'Angelo, Christopher J. Clarke, Liana C. Silva, May 2019, Cascais, Portugal
Communication dans un congrès hal-04974329 v1

TNF-dependent mechanisms of immune escape and resistance to immunotherapy

Bruno Ségui
3rd European R&D Day in immuno-oncology, Mar 2019, Amsterdam, Netherlands
Communication dans un congrès hal-04974781 v1

Targeting TNF-alpha to overcome resistance to immunotherapy in melanoma

Bruno Ségui
11th Summer School on Medicines, Denis Deblois, Jun 2019, Montreal, Canada
Communication dans un congrès hal-04974731 v1

Resistance of Melanoma to Immune Checkpoint Inhibitors is Overcome by Targeting the Sphingosine Kinase 1

Céline Colacios , Caroline Imbert , Anne Montfort , Marine Fraisse , Elie Marcheteau et al.
Canceropole GSO, Canceropole GSO, Nov 2019, Arcachon, France
Communication dans un congrès hal-04993281 v1

Anti-TNF in melanoma immunotherapy: from basic findings to the clinic

Bruno Ségui
9ème Journée d’Immunologie et Immunothérapie des Cancers (JIIC), Dec 2019, Dijon, France
Communication dans un congrès hal-04974761 v1

Combining TNF-targeting antibodies to immune checkpoint inhibitors in melanoma

Anne Montfort , Florie Bertrand , Elie Marcheteau , Caroline Imbert , Julia Gilhodes et al.
Toulouse Oncoweek, Feb 2018, Toulouse, France
Communication dans un congrès hal-04970883 v1

Preclinical and patient transcriptomics RNA-seq highlight the impact of TNF blockade on the inflammatory status of melanoma tumours.

Matthieu Genais , Mathieu Virazels , Anne Montfort , Vera Pancaldi , Bruno Ségui
EACR conferences: Defence is the Best Attack: Immuno-Oncology Breakthroughs, May 2023, Barcelona (ES), Spain
Poster de conférence hal-04991620 v1

TNF plasma levels in advanced melanoma patients treated with immune checkpoint inhibitors: results from the MELANFα clinical study.

Mathieu Virazels , Amélie Lusque , Thomas Filleron , Clara-Maria Scarlata , Maha Ayyoub et al.
Defence is the Best Attack: Immuno-Oncology Breakthroughs, May 2023, Barcelona, France
Poster de conférence hal-04971045 v1

Triple combination of ipilimumab + nivolumab + anti-TNF in treatment naive melanoma patients: Final analysis of TICIMEL, a phase Ib prospective clinical trial

Bruno Ségui , Nicolas Meyer , Amélie Lusque , Mathieu Virazels , Thomas Filleron et al.
ESMO congress 2022, Sep 2022, Paris, France. Annals of Oncology, 33 (suppl_7), pp.S936-S937, 2022, ⟨10.1016/j.annonc.2022.07.972⟩
Poster de conférence hal-04975541 v1

TNF plasma levels in advanced melanoma patients treated with immune checkpoint inhibitors: results from the MELANFα clinical study.

Mathieu Virazels , Anne Montfort , Amélie Lusque , Thomas Filleron , Céline Colacios et al.
ESMO Congress 2022, Sep 2022, Paris, France
Poster de conférence hal-04971055 v1

Combining TNF blockade with immune checkpoint inhibitors in advanced melanoma patients

Mathieu Virazels , Anne Montfort , Thomas Filleron , Carine Dufau , Maha Ayyoub et al.
53rd congress of the French Society of Immunology, Dec 2021, Paris, France
Poster de conférence hal-04970987 v1

Neutral sphingomyelinase 2 heightens anti-melanoma immune response and synergizes with immune checkpoint inhibitors.

Anne Montfort , Florie Bertrand , Julia Rochotte , Nathalie Andrieu-Abadie , Thierry Levade et al.
52ème Congrès de la Société Française d'immunologie (SFI), Nov 2019, Nantes, France
Poster de conférence hal-04970950 v1