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Caroline Gaucher

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A Smooth Muscle Cell-Based Ferroptosis Model to Evaluate Iron-Chelating Molecules for Cardiovascular Disease Treatment

Sarah El Hajj , Laetitia Canabady-Rochelle , Isabelle Fries-Raeth , Caroline Gaucher
Current Issues in Molecular Biology, 2024, 46 (2), pp.1348-1359. ⟨10.3390/cimb46020086⟩
Journal articles hal-04439775v1
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Nature-Inspired Bioactive Compounds: A Promising Approach for Ferroptosis-Linked Human Diseases?

Sarah El Hajj , Laetitia Canabady-Rochelle , Caroline Gaucher
Molecules, 2023, 28 (2), pp.2636. ⟨10.3390/molecules28062636⟩
Journal articles hal-04248432v1
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Metal-chelating activity of soy and pea protein hydrolysates obtained after different enzymatic treatments from protein isolates

El Sarah Hajj , Rachel Irankunda , Jairo Andrés Camaño Echavarría , Philippe Arnoux , Cédric Paris
Food Chemistry, 2023, 405, pp.134788. ⟨10.1016/j.foodchem.2022.134788⟩
Journal articles hal-04249612v1
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Phenotypic Modulation of Macrophages and Vascular Smooth Muscle Cells in Atherosclerosis—Nitro-Redox Interconnections

Justine Bonetti , Alessandro Corti , Lucie Lerouge , Alfonso Pompella , Caroline Gaucher
Antioxidants , 2021, 10 (4), pp.516. ⟨10.3390/antiox10040516⟩
Journal articles hal-03182782v1

Analytical methods for the quantification of selenium species in biological matrix: Where are we?

Rama Alhasan , Caroline Perrin , Claus Jacob , Caroline Gaucher
Current Nutraceuticals, 2021, 02, pp.e171121198032. ⟨10.2174/2665978602666211117154655⟩
Journal articles hal-03544453v1
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Electrically switchable nanolever technology for the screening of metal-chelating peptides in hydrolysates

Sarah El Hajj , Cindy Tatiana Sepúlveda Rincón , Jean-Michel Girardet , Céline Cakir-Kiefer , Loïc Stefan
Journal of Agricultural and Food Chemistry, 2021, 69 (31), pp.8819-8827. ⟨10.1021/acs.jafc.1c02199⟩
Journal articles hal-03447722v1
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Dextran-covered pH-sensitive oily core nanocapsules produced by interfacial Reversible Addition-Fragmentation chain transfer miniemulsion polymerization

Laura Marcela Forero Ramirez , Ariane Boudier , Caroline Gaucher , Jerome Babin , Alain Durand
Journal of Colloid and Interface Science, 2020, 569, pp.57-67. ⟨10.1016/j.jcis.2020.02.066⟩
Journal articles hal-02651686v1

Editorial: Targeting Monocytes/Macrophages to Treat Atherosclerotic Inflammation

Alessandro Corti , Caroline Gaucher , Alfonso Pompella
Frontiers in Pharmacology, 2020, 11, pp.86. ⟨10.3389/fphar.2020.00086⟩
Journal articles hal-02922592v1

ROS and GSH-responsive S-nitrosoglutathione functionalized polymeric nanoparticles to overcome multidrug resistance in cancer

Wen Wu , Min Chen , Tingrong Luo , Ying Fan , Jinqiang Zhang
Acta Biomaterialia, 2020, 103, pp.259-271. ⟨10.1016/j.actbio.2019.12.016⟩
Journal articles hal-02501406v1
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Challenging development of storable particles for oral delivery of a physiological nitric oxide donor

Yi Zhou , Caroline Gaucher , Isabelle Fries , Mehmet-Akif Hobekkaya , Charlène Martin
Nitric Oxide: Biology and Chemistry, 2020, 104-105, pp.1-10. ⟨10.1016/j.niox.2020.08.001⟩
Journal articles hal-02922699v1
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S-Nitrosothiols as potential therapeutics to induce a mobilizable vascular store of nitric oxide to counteract endothelial dysfunction

Caroline Perrin-Sarrado , Yi Zhou , Valérie Salgues , Marianne Parent , Philippe Giummelly
Biochemical Pharmacology, 2020, 173, pp.113686. ⟨10.1016/j.bcp.2019.113686⟩
Journal articles hal-02493406v1
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Edaravone-Loaded Alginate-Based Nanocomposite Hydrogel Accelerated Chronic Wound Healing in Diabetic Mice

Ying Fan , Wen Wu , Yu Lei , Caroline Gaucher , Shuchen Pei
Marine drugs, 2019, 17 (5), pp.285. ⟨10.3390/md17050285⟩
Journal articles hal-02501407v1

Personalized nutrition in aging society: redox control of major-age related diseases through the NutRedOx Network (COST Action CA16112)

Josep Tur , Claus Jacob , Patrick Chaimbault , Mohammad Tadayyon , Elke Richling
Free Radical Research, 2019, 53 (suppl 1), pp.1163-1170. ⟨10.1080/10715762.2019.1572890⟩
Journal articles hal-02044918v1

Selenoneine: a Unique Reactive Selenium Species From the Blood of Tuna With Implications for Human Diseases

Rama Alhasan , Muhammad Jawad Nasim , Claus Jacob , Caroline Gaucher
Current Pharmacology Reports, 2019, 5, pp.163-173. ⟨10.1007/s40495-019-00175-8⟩
Journal articles hal-02493418v1

Selenium Donors at the Junction of Inflammatory Diseases

Rama Alhasan , Ammar Kharma , Pierre Leroy , Claus Jacob , Caroline Gaucher
Current Pharmaceutical Design, 2019, 25 (15), pp.1707-1716. ⟨10.2174/1381612825666190701153903⟩
Journal articles hal-02493415v1
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S‐nitrosoglutathione inhibits cerebrovascular angiotensin II‐dependent and ‐independent AT1 receptor responses : A possible role of S‐nitrosation

Marie‐lynda Bouressam , Sandra Lecat , Alexandre Raoul , Caroline Gaucher , Caroline Perrin-Sarrado
British Journal of Pharmacology, 2019, 176 (12), pp.2049-2062. ⟨10.1111/bph.14644⟩
Journal articles hal-02132085v1
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First multi-reactive polysaccharide-based transurf to produce potentially biocompatible dextran-covered nanocapsules

Laura Marcela Forero Ramirez , Jérôme Babin , Ariane Boudier , Caroline Gaucher , Marc Schmutz
Carbohydrate Polymers, 2019, 224, pp.115153. ⟨10.1016/j.carbpol.2019.115153⟩
Journal articles hal-02267696v1
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Intestinal absorption of S -nitrosothiols: permeability and transport mechanisms

Justine Bonetti , Yi Zhou , Marianne Parent , Igor Clarot , Haiyan Yu
Biochemical Pharmacology, 2018, 155, pp.21-31. ⟨10.1016/j.bcp.2018.06.018⟩
Journal articles hal-01824879v1
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Glutathione: Antioxidant Properties Dedicated to Nanotechnologies

Caroline Gaucher , Ariane Boudier , Justine Bonetti , Igor Clarot , Pierre Leroy
Antioxidants , 2018, 7 (5), pp.62. ⟨10.3390/antiox7050062⟩
Journal articles hal-01823460v1

Higher‐energy collision‐induced dissociation for the quantification by liquid chromatography/tandem ion trap mass spectrometry of nitric oxide metabolites coming from S ‐nitroso‐glutathione in an in vitro model of the intestinal barrier

Haiyan Yu , Justine Bonetti , Caroline Gaucher , Isabelle Fries , Lionel Vernex‐loset
Rapid Communications in Mass Spectrometry, 2018, 33 (1), pp.1-11. ⟨10.1002/rcm.8287⟩
Journal articles hal-02044975v1

Flush with a flash: natural three-component antimicrobial combinations based on S-nitrosothiols, controlled superoxide formation and “domino” reactions leading to peroxynitrite

Rama Alhasan , Ammar Kharma , Muhammad Jawad Nasim , Ahmad Yaman Abdin , Justine Bonetti
MedChemComm, 2018, 9 (12), pp.1994-1999. ⟨10.1039/C8MD00414E⟩
Journal articles hal-02044926v1

Synthesis of novel mono and bis nitric oxide donors with high cytocompatibility and release activity

Tanya Sahyoun , Caroline Gaucher , Yi Zhou , Naïm Ouaïni , Raphaël Schneider
Bioorganic and Medicinal Chemistry Letters, 2018, 28 (20), pp.3329-3332. ⟨10.1016/j.bmcl.2018.09.009⟩
Journal articles hal-01896757v1
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Polymeric Nanoparticles for Increasing Oral Bioavailability of Curcumin

Anita Umerska , Caroline Gaucher , Felipe Oyarzun-Ampuero , Isabelle Fries , Florence Colin
Antioxidants , 2018, 7 (4), pp.46. ⟨10.3390/antiox7040046⟩
Journal articles hal-01780420v1
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Oxidative stress enhances and modulates protein S -nitrosation in smooth muscle cells exposed to S -nitrosoglutathione

E. Belcastro , W. Wu , I. Fries-Raeth , A. Corti , A. Pompella
Nitric Oxide: Biology and Chemistry, 2017, 69, pp.10-21. ⟨10.1016/j.niox.2017.07.004⟩
Journal articles hal-01593873v1

Upregulation of endothelial gene markers in Wharton's jelly mesenchymal stem cells cultured on polyelectrolyte multilayers

Hassan Rammal , Chaza Harmouch , Clément Maerten , Caroline Gaucher , Fouzia Boulmedais
Journal of Biomedical Materials Research Part A, 2017, 105 (1), pp.292-300. ⟨10.1002/jbm.a.35868⟩
Journal articles hal-01712202v1

Relationship between Antioxidant Capacity and Food Chemistry

Caroline Gaucher , Pierre Leroy , Ariane Boudier
World Journal of Chemical Education, 2017, 5 (2), pp.78-85. ⟨10.12691/wjce-5-2-7⟩
Journal articles hal-01686111v1

Encapsulation and release of hydrophobic molecules from particles of gelled triglyceride with aminoacid-based low-molecular weight gelators

Sebastian-Camilo Salazar-Bautista , Asma Chebil , Guillaume Pickaert , Caroline Gaucher , Brigitte Jamart-Gregoire
Colloids and Surfaces A: Physicochemical and Engineering Aspects, 2017, 514, pp.11-20. ⟨10.1016/j.colsurfa.2016.11.045⟩
Journal articles hal-02055143v1
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Regulation of protein function by S-nitrosation and S-glutathionylation: processes and targets in cardiovascular pathophysiology

Eugenia Belcastro , Caroline Gaucher , Alessandro Corti , Pierre Leroy , Isabelle Lartaud
Biological Chemistry, 2017, 398 (12), pp.1267-1293. ⟨10.1515/hsz-2017-0150⟩
Journal articles hal-01593870v1

Conformational studies of new pseudotripeptide with pyrazine amidoxime motif and simplified analogs using IR, NMR spectroscopy, and molecular dynamic simulations

Olga Ovdiichuk , Olga Hordiyenko , Evgenia Fotou , Caroline Gaucher , Axelle Arrault
Structural Chemistry, 2017, 28 (3), pp.813-822. ⟨10.1007/s11224-016-0870-2⟩
Journal articles hal-01627739v1
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Polymer nanocomposites enhance S-nitrosoglutathione intestinal absorption and promote the formation of releasable nitric oxide stores in rat aorta

Wen Wu , Caroline Perrin-Sarrado , Hui Ming , Isabelle Lartaud , Philippe Maincent
Nanomedicine: Nanotechnology, Biology and Medicine, 2016, 12 (7), pp.1795-1803. ⟨10.1016/j.nano.2016.05.006⟩
Journal articles hal-01493332v1

S -Nitrosothiols—NO donors regulating cardiovascular cell proliferation: Insight into intracellular pathway alterations

Marek Rychter , Caroline Gaucher , Ariane Boudier , Pierre Leroy , Janina Lulek
International Journal of Biochemistry and Cell Biology, 2016, 78, pp.156-161. ⟨10.1016/j.biocel.2016.07.003⟩
Journal articles hal-01686098v1

Interaction of recombinant octameric hemoglobin with endothelial cells

Caroline Gaucher , Élisa Domingues-Hamdi , Christine Prin-Mathieu , Patrick Menu , Véronique Baudin-Creuza
Comptes Rendus Biologies, 2015, 338 (2), pp.95-102. ⟨10.1016/j.crvi.2014.11.004⟩
Journal articles hal-01291903v1

Time lasting S-nitrosoglutathione polymeric nanoparticles delay cellular protein S-nitrosation.

Wen Wu , Caroline Gaucher , Roudayna Diab , Isabelle Fries , Yu-Ling Xiao
European Journal of Pharmaceutics and Biopharmaceutics, 2015, 89, pp.1-8. ⟨10.1016/j.ejpb.2014.11.005⟩
Journal articles hal-01281136v1

Nitric oxide-eluting scaffolds and their interaction with smooth muscle cells in vitro

Marianne Parent , Ariane Boudier , Isabelle Fries , Aleksandra Gostyńska , Marek Rychter
Journal of Biomedical Materials Research Part A, 2015, 103 (10), pp.3303-3311. ⟨10.1002/jbm.a.35464⟩
Journal articles hal-01277820v1

Polymer nanocomposite particles of S-nitrosoglutathione: A suitable formulation for protection and sustained oral delivery.

Wen Wu , Caroline Gaucher , Isabelle Fries , Xian-Ming Hu , Philippe Maincent
International Journal of Pharmaceutics, 2015, 495 (1), pp.354-61. ⟨10.1016/j.ijpharm.2015.08.074⟩
Journal articles hal-01281137v1

S-nitrosation/Denitrosation in Cardiovascular Pathologies: Facts and Concepts for the Rational Design of S-nitrosothiols

Caroline Gaucher , Ariane Boudier , Fatima Dahboul , Marianne Parent , Pierre Leroy
Current Pharmaceutical Design, 2013, 19 (3), pp.458-472. ⟨10.2174/1381612811306030458⟩
Journal articles hal-01273168v1
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Endothelial γ-Glutamyltransferase Contributes to the Vasorelaxant Effect of S-Nitrosoglutathione in Rat Aorta

Fatima Dahboul , Pierre Leroy , Katy Maguin Gate , Ariane Boudier , Caroline Gaucher
PLoS ONE, 2012, 7 (9), pp.e43190. ⟨10.1371/journal.pone.0043190⟩
Journal articles hal-01491876v1

Automated detection of hepatotoxic compounds in human hepatocytes using HepaRG cells and image-based analysis of mitochondrial dysfunction with JC-1 dye.

K. Pernelle , Rémy Le Guevel , Denise Glaise , C Gaucher-Di Stasio , T. Le Charpentier
Toxicology and Applied Pharmacology, 2011, 254 (3), pp.256-66. ⟨10.1016/j.taap.2011.04.018⟩
Journal articles hal-00740177v1

The importance of the effect of shear stress on endothelial cells in determining the performance of hemoglobin based oxygen carriers

Caroline Gaucher-Di Stasio , Estelle Paternotte , Christine Prin-Mathieu , Brandon Reeder , Gaël Poitevin
Biomaterials, 2009, 30 (4), pp.445 - 451. ⟨10.1016/j.biomaterials.2008.09.051⟩
Journal articles hal-01824915v1

Polyelectrolyte Films Boost Progenitor Cell Differentiation into Endothelium-like Monolayers

Nicolas Berthélémy , Halima Kerdjoudj , Caroline Gaucher , Pierre Schaaf , Jean-François Stoltz
Advanced Materials, 2008, 20 (14), pp.2674-2678. ⟨10.1002/adma.200702418⟩
Journal articles hal-02164025v1

How to Evaluate Blood Substitutes for Endothelial Cell Toxicity

Caroline Gaucher , Patrick Menu
Antioxidants and Redox Signaling, 2008, 10 (7), pp.1153 - 1162. ⟨10.1089/ars.2007.1982⟩
Journal articles hal-01593881v1

Review: Behaviour of endothelial cells face to hypoxia

Estelle Paternotte , Caroline Gaucher , Pierre Labrude , Jean-François Stoltz , Patrick Menu
Bio-Medical Materials and Engineering, 2008, 18, pp.295-309. ⟨10.3233/BME-2008-0541⟩
Journal articles hal-01824927v1

In vitro impact of physiological shear stress on endothelial cells gene expression profile

Caroline Gaucher , Carole Devaux , Cédric Boura , Patrick Lacolley , Jean-François Stoltz
Clinical Hemorheology and Microcirculation, 2007, Selected Papers from 1st Meeting on “Cardiovascular Biology: Endothelial Cell in Health and Hypertension”, 30 June–1 July 2006, Prague, Czech Republic, 37, pp.99-107
Journal articles hal-01493347v1

Cancer 3D bio-printed models and their further studies in microfluidic devices

Claire Godier , Zakaria Baka , Daniele Pedroni , Lina Bezdetnaya , Caroline Gaucher
33rd Annual Conference of the European Society for Biomaterials, ESB 2023, European Society for Biomaterials (ESB), Sep 2023, Davos, Switzerland
Conference papers hal-04190078v1

Functional evaluation of new biomolecules

Sophie Rahuel-Clermont , Caroline Gaucher
International conference on "Biomolecules: Research & Development, Markets and Acceptability", 2019, Palma de Mallorca, Spain
Conference papers hal-02997667v1
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Antioxidant Properties of S-Nitrosoglutathione and Nanotechnologies

Marianne Parent , Yi Zhou , Justine Bonetti , Caroline Perrin-Sarrado , Isabelle Lartaud
Natural Products and the Hallmarks of Chronic Diseases - NutRedOx COST Action 16112, Mar 2019, Luxembourg, Luxembourg. pp.15, ⟨10.3390/proceedings2019011015⟩
Conference papers hal-02132116v1
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Nano or Micro: 3 Different Particles to Deliver and Protect S-Nitrosoglutathione for Oral Route Administration

Yi Zhou , Caroline Gaucher , Isabelle Fries , Marianne Parent
Natural Products and the Hallmarks of Chronic Diseases - NutRedOx COST Action 16112, Mar 2019, Luxembourg, Luxembourg. pp.14, ⟨10.3390/proceedings2019011014⟩
Conference papers hal-02132107v1

SPR screening of metal-chelating peptides for their antioxidant properties in laboratory-produced hydrolysates: effect of proteolysis conditions.

Sarah El Hajj , Céline Cakir-Kiefer , Philippe Arnoux , Loïc Stefan , Katalin Selmeczi
SFGP2019, Oct 2019, Nantes, France
Conference papers hal-02938887v1

Synthesis of nitric oxide double donors, study of their cytotoxicity and pharmacological activities

Tanya Sahyoun , Ouaini Naim , Caroline Gaucher , Raphaël Schneider , Axelle Arrault
XXII International Conference on Organic Synthesis, 22-ICOS, Sep 2018, Florence, Italy
Conference papers hal-01881531v1

Use of a muti-reactive surfactant for an interfacially confined polymerization process in miniemulsion: Control of the end-use properties for oily-core nanocapsules

Laura Marcela Forero Ramirez , Jérôme Babin , Ariane Boudier , Caroline Gaucher , Alain Durand
16ème Congrès de la Société Française de Génie des Procédés, Jul 2017, Nancy, France
Conference papers hal-03239700v1

Biocompatible oily-core nanocapsules via interfacial RAFT miniemulsion polymerization

Laura Marcela Forero Ramirez , Ariane Boudier , Caroline Gaucher , Jérôme Babin , Alain Durand
14e Journée Scientifique du GFP section Grand-Est, Jun 2016, nancy, France
Conference papers hal-03239639v1

Mesenchymal stem cells as a promising source for endothelial cells in vascular tissue engineering

H. Rammal , C. Harmoush , M. Gentils , Fouzia Boulmedais , Caroline Gaucher
23rd Annual Meeting of the European Tissue Repair Society, Oct 2013, Reims, France. pp.A79
Conference papers hal-01513829v1

Surface plasmon resonance: an original method for screening metal-chelating peptides in hydrolysates for their antioxidant properties

Laetitia Canabady-Rochelle , Katalin Selmeczi , Sabrina Collin , Sarah El Hajj , Caroline Gaucher
21st Congress of the Groupement Français des Peptides et des Protéines, May 2019, Amboise, France
Conference poster hal-02938896v1

Metal-chelating peptides in hydrolysates: a way to valorize protein-containing co-products in a bioeconomy strategy

Sarah El Hajj , Céline Cakir-Kiefer , Loïc Stefan , Steve Pontvianne , Philippe Arnoux
Séminaire de l’école doctorale SIMPPE, Mar 2019, Nancy, France
Conference poster hal-02939921v1

Metal-chelating peptides in hydrolysates: production, characterization and screening

El Sarah Hajj , Céline Cakir-Kiefer , Stefan Loic , Steve Pontvianne , Philippe Arnoux
LUE International Conference “ Biomolecules: Research & Development, Markets and Acceptability”, Oct 2019, Palma de Majorca, Spain
Conference poster hal-02938859v1

Innovative Screening Methodology of Metal Chelating Peptides with Antioxidant Properties using Surface Plasmon Resonance

Caroline Gaucher , Igor Clarot , Cedric Paris , Stephane Desobry , Céline Cakir-Kiefer
Impact Biomolecules, May 2018, Nancy, France
Conference poster hal-02939980v1

Screening and Separation of Metal Chelating Peptides for Nutrition and Health Applications

Sandrine Boschi-Muller , Cédric Paris , Stephane Desobry , Katalin Selmeczi , Patrick Chaimbault
Impact Biomolecules, May 2018, Nancy, France
Conference poster hal-02939988v1

Intestine permeability of S-nitrosoglutathione as a potential nitric oxide donor via oral administration

Justine Bonetti , Haiyan Yu , Hui Ming , Anne Sapin-Minet , Isabelle Fries
World Congress and Annual SFRR-E Conference 2017 Metabolic Stress and Redox Regulation, Jun 2017, Berlin, Germany. 108 (Suppl 1), pp.S75, 2017, ⟨10.1016/j.freeradbiomed.2017.04.253⟩
Conference poster hal-02894481v1

Screening and Purification of Metal Chelating Peptides in Hydrolysates for their Antioxidant Properties

Laetitia Canabady-Rochelle , Cédric Paris , Katalin Selmeczi , Caroline Gaucher-Di Stasio , Igor Clarot
17th International Conference on Oxidative Stress Reduction, Redox Homeostasis and Antioxidants, Jun 2016, Paris, France
Conference poster hal-02939135v1

Valorisation de composés phénoliques antioxydants présents dans des bio-huiles produites par conversion thermochimique de la biomasse

Laetitia Canabady-Rochelle , Laetitia Cesari , M.A. François , Katalin Selmeczi , Olivier Joubert
Conférence Adebiotech. Modulation du stress oxydant : nouveaux concepts pour de nouvelles applications, May 2016, Romainville, France
Conference poster hal-02940016v1

Etude des Capacités Antioxydantes et Antimicrobiennes de la Plante Retama sphaerocarpa

A. Benaissa , R. Cherfia , Laetitia Canabady-Rochelle , Dominique Perrin , Patrick Chaimbault
Conférence Adebiotech. Modulation du stress oxydant : nouveaux concepts pour de nouvelles applications., May 2016, Romainville, France
Conference poster hal-02940015v1
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Screening and Purification of Metal Chelating Peptides in Hydrolysates for their Antioxidant Properties.

Laetitia Canabady-Rochelle , Cédric Paris , Katalin Selmeczi , Caroline Gaucher , Igor Clarot
ISANH 2016, 2016, Paris, France
Conference poster hal-01391695v1

Revisited methods for the determination of reducing power and metal chelating ability of antioxidant peptides

Laetitia Canabady-Rochelle , Christelle Harscoat-Schiavo , Caroline Gaucher , Violette Kessler , Arnaud Aymes
15th International Conference on Oxidative Stress Reduction, Redox Homeostasis and Antioxidants, Jun 2015, Paris, France
Conference poster hal-02939167v1

Application in nutrition: mineral binding

Sarah El Hajj , Tatiana Sepulveda-Rincon , Cédric Paris , Tristan Giraud , Gizella Csire
Fidel Toldra; Jianping Wu. Biologically Active Peptides: from Basic Science to Applications for Human Health, Academic Press, pp.455-494, 2021, 9780128213896. ⟨10.1016/B978-0-12-821389-6.00016-9⟩
Book sections hal-03267562v1