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Catherine Belzung

Professeure à l'Université de Tours
Open access
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Professeure en Neurosciences à l'Université de Tours, je fais de la recherche dans le domaine de la Psychiatrie en favorisant une approche translationelle et multidisciplinaire. Actuellement je dirige l'Unité Inserm iBrain (U 1253,, je coordone une chaire Unesco en maltraitance infantile ( et je suis Vice Présidente de la Société des Neurosciences ( ). Je suis aussi membre du Conseil scientifique de l'Inserm et du conseil scientifique de la FRM (Fondation pour la Recherche Médicale).
As a Professor of Neuroscience at the University of Tours, I carry out research in the field of psychiatry, favouring a translational and multidisciplinary approach. I currently head the Inserm iBrain Unit (U 1253,, I coordinate an Unesco chair in child abuse ( and I am Vice Chair of the Society for Neuroscience ( I am also a member of the Inserm Scientific Advisory Board and the FRM (Fondation pour la Recherche Médicale) Scientific Advisory Board.

Research domains

Neuroscience Psychiatrics and mental health



Improvement of hedonic perception of odors as a marker of treatment response to Escitalopram - Olfactory changes through an open-label antidepressant trial

François Kazour , Boriana Atanasova , Thomas Desmidt , Valérie Gissot , Apolline Lefevre
Revista Brasileira de Psiquiatria, 2023, ⟨10.47626/1516-4446-2023-3107⟩
Journal articles hal-04230729v1

Neurostimulation as a treatment for mood disorders in patients: recent findings

Masoud Afshari , Catherine Belzung , Solal Bloch
Current Opinion in Psychiatry, 2023, 36 (1), pp.14-19. ⟨10.1097/YCO.0000000000000835⟩
Journal articles hal-04230758v1
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Changes in cerebral connectivity and brain tissue pulsations with the antidepressant response to an equimolar mixture of oxygen and nitrous oxide: an MRI and ultrasound study

Thomas Desmidt , Paul-Armand Dujardin , Frédéric Andersson , Bruno Brizard , Jean-Pierre Remeniéras
Molecular Psychiatry, 2023, 28 (9), pp.3900-3908. ⟨10.1038/s41380-023-02217-6⟩
Journal articles hal-04196063v1

Glutamatergic synapse in autism: a complex story for a complex disorder

Laurent Galineau , Nicolas Arlicot , Anne-Claire Dupont , Frédéric Briend , Emmanuelle Houy-Durand
Molecular Psychiatry, 2022, 28 (2), pp.801-809. ⟨10.1038/s41380-022-01860-9⟩
Journal articles hal-04424686v1
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Validation of the French Version of the Positivity Scale (P Scale)

Alexis Vancappel , Robert Courtois , Marta Andrea Siragusa , Coraline Hingray , Christian Réveillère
Frontiers in Psychology, 2022, 12, pp.724253. ⟨10.3389/fpsyg.2021.724253⟩
Journal articles hal-03559115v1
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Benzodiazepine use and neuroimaging markers of Alzheimer's disease in nondemented older individuals: an MRI and 18F Florbetapir PET study in the MEMENTO cohort

Quentin Gallet , Vincent Bouteloup , Maxime Locatelli , Marie-Odile Habert , Marie Chupin
Neuropsychopharmacology, 2022, 47 (5), pp.1114-1120. ⟨10.1038/s41386-021-01246-5⟩
Journal articles hal-03512885v1
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Adult neurogenesis augmentation attenuates anhedonia and HPA axis dysregulation in a mouse model of chronic stress and depression

Hoda Eliwa , Bruno Brizard , Anne-Marie Le Guisquet , René Hen , Catherine Belzung
Psychoneuroendocrinology, 2021, 124, pp.105097 -. ⟨10.1016/j.psyneuen.2020.105097⟩
Journal articles hal-03492867v1
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miR-323a regulates ERBB4 and is involved in depression.

Laura M Fiori , Aron Kos , Rixing Lin , Jean-Francois Théroux , Juan Pablo Lopez
Molecular Psychiatry, 2020, ⟨10.1038/s41380-020-00953-7⟩
Journal articles hal-03019942v1
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Left amygdala volume and brain tissue pulsatility are associated with neuroticism: an MRI and ultrasound study

Marta Andrea Siragusa , Thomas Rufin , Robert Courtois , Catherine Belzung , Frédéric Andersson
Brain imaging and behavior (Brain Imaging Behav), 2020, pp.1499-1507. ⟨10.1007/s11682-020-00348-w⟩
Journal articles hal-03265218v1
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When classical music relaxes the brain: An experimental study using Ultrasound Brain Tissue Pulsatility Imaging

Marta Andrea Siragusa , Bruno Brizard , Paul-Armand Dujardin , Jean-Pierre Remenieras , Frédéric Patat
International Journal of Psychophysiology, 2020, 150, pp.29 - 36. ⟨10.1016/j.ijpsycho.2020.01.007⟩
Journal articles hal-03489686v1
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A systematic review of ultrasound imaging and therapy in mental disorders

Marta Andrea Siragusa , Jean-Pierre Remenieras , Ayache Bouakaz , Jean-Michel Escoffre , Frédéric Patat
Progress in Neuro-Psychopharmacology and Biological Psychiatry, 2020, 101, pp.109919. ⟨10.1016/j.pnpbp.2020.109919⟩
Journal articles inserm-02519433v1

Sustained corticosterone rise in the prefrontal cortex is a key factor for chronic stress-induced working memory deficits in mice

Gaelle Dominguez , Nadia Henkous , Thomas Prevot , Jean-Louis Guillou , Vincent David
Neurobiology of Stress, 2019, 10, pp.100161. ⟨10.1016/j.ynstr.2019.100161⟩
Journal articles hal-02379037v1
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Benzodiazepine use and brain amyloid load in nondemented older individuals a florbetapir PET study in the Multidomain Alzheimer Preventive Trial cohort

Thomas Desmidt , Julien Delrieu , Thibaud Lebouvier , Gabriel Robert , Renaud David
Neurobiology of Aging, 2019, 84, pp.61-69. ⟨10.1016/j.neurobiolaging.2019.08.008⟩
Journal articles hal-02307424v1
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Sustained corticosterone rise in the prefrontal cortex is a key factor for chronic stress-induced working memory deficits in mice

Gaelle Dominguez , Nadia Henkous , Thomas Prevot , Vincent David , Jean-Louis Guillou
Neurobiology of Stress, 2019, 10, pp.100161. ⟨10.1016/j.ynstr.2019.100161⟩
Journal articles hal-03087310v1

Repeated diazepam administration reversed working memory impairments and glucocorticoid alterations in the prefrontal cortex after short but not long alcohol-withdrawal periods

G. Dominguez , N. Henkous , C. Pierard , Catherine Belzung , N. Mons
Cognitive, Affective, and Behavioral Neuroscience, 2018, 18 (4), pp.665-679. ⟨10.3758/s13415-018-0595-3⟩
Journal articles hal-02347811v1

Alcohol withdrawal induces long-lasting spatial working memory impairments: relationship with changes in corticosterone response in the prefrontal cortex

Gaelle Dominguez , Catherine Belzung , Christophe Pierard , Vincent David , Nadia Henkous
Addiction Biology, 2017, 22 (4), pp.898-910. ⟨10.1111/adb.12371⟩
Journal articles hal-03087313v1

Alcohol withdrawal induces long-lasting spatial working memory impairments: relationship with changes in corticosterone response in the prefrontal cortex

Gaelle Dominguez , Catherine Belzung , Christophe Piérard , Vincent David , Nadia Henkous
Addiction Biology, 2017, 22 (4), pp.898-910. ⟨10.1111/adb.12371⟩
Journal articles hal-02517717v1
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Translational Identification of Transcriptional Signatures of Major Depression and Antidepressant Response

Mylène Hervé , Aurélie Bergon , Anne-Marie Le Guisquet , Samuel Leman , Julia-Lou Consoloni
Frontiers in Molecular Neuroscience, 2017, 10, pp.248. ⟨10.3389/fpsyt.2016.00072⟩
Journal articles hal-01575031v1

Cingulate Overexpression of Mitogen-Activated Protein Kinase Phosphatase-1 as a Key Factor for Depression

Florent Barthas , Muris Humo , Ralf Gilsbach , Elisabeth Waltisperger , Meltem Karatas
Biological Psychiatry, 2017, 82 (5), pp.370-379. ⟨10.1016/j.biopsych.2017.01.019⟩
Journal articles hal-02106543v1

Rescuing prefrontal cAMP-CREB pathway reverses working memory deficits during withdrawal from prolonged alcohol exposure

G. Dominguez , M. Dagnas , L. Decorte , M. Vandesquille , Catherine Belzung
Brain Structure and Function, 2016, 221 (2), pp.865-877. ⟨10.1007/s00429-014-0941-3⟩
Journal articles hal-02517753v1

Identity matters to individuals: Group assessment cannot be reduced to collective performance

Catherine Belzung , Etienne Billette de Villemeur , Anouk Grevin , Gennaro Iorio
Behavioral and Brain Sciences, 2016, 39, ⟨10.1017/s0140525x15001272⟩
Journal articles hal-01533527v1
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Brain organic cation transporter 2 controls response and vulnerability to stress and GSK3β signaling

Thomas Couroussé , Alexandre Bacq , Catherine Belzung , Bruno Guiard , Laure Balasse
Molecular Psychiatry, 2015, 20 (7), pp.889-900. ⟨10.1038/mp.2014.86⟩
Journal articles inserm-02008043v2

Prenatal Exposure to Methylphenidate Affects the Dopamine System and the Reactivity to Natural Reward in Adulthood in Rats

François-Xavier Lepelletier , Clovis Tauber , Céline Nicolas , Marcello Solinas , Pierre Castelnau
International Journal of Neuropsychopharmacology, 2015, 18 (4), ⟨10.1093/ijnp/pyu044⟩
Journal articles hal-02488617v1

The temporal dynamic of emotional emergence

Thomas Desmidt , Mael Lemoine , Catherine Belzung , Natalie Depraz
Phenomenology and the Cognitive Sciences, 2014, 13 (4), pp.557-578. ⟨10.1007/s11097-014-9377-8⟩
Journal articles hal-01098105v1
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Perceptive Biases in Major Depressive Episode

Marine Naudin , Tatiana Carl , Simon Surguladze , Catherine Guillen , Philippe Gaillard
PLoS ONE, 2014, 9 (2), pp.e86832. ⟨10.1371/journal.pone.0086832⟩
Journal articles hal-02524274v1
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Mechanisms of antidepressant resistance

Wissam El-Hage , Samuel Leman , Vincent Camus , Catherine Belzung
Frontiers in Pharmacology, 2013, 4, ⟨10.3389/fphar.2013.00146⟩
Journal articles hal-02524277v1

Does reduction of fearfulness tend to reduce pessimistic-like judgment in lambs?

Alexandra Destrez , Véronique Deiss , Catherine Belzung , Caroline Lee , Alain Boissy
Applied Animal Behaviour Science, 2012, 139 (3-4), pp.233 - 241. ⟨10.1016/j.applanim.2012.04.006⟩
Journal articles hal-01923131v1

Is unpredictable chronic mild stress (UCMS) a reliable model to study depression-induced neuroinflammation?

Rai Khalid Farooq , Elsa Isingrini , Arnaud Tanti , Anne-Marie Le Guisquet , Nicolas Arlicot
Behavioural Brain Research, 2012, 231 (1), pp.130-137. ⟨10.1016/j.bbr.2012.03.020⟩
Journal articles hal-03389598v1

Fluoxetine Effect on Aortic Nitric Oxide-Dependent Vasorelaxation in the Unpredictable Chronic Mild Stress Model of Depression in Mice

Elsa Isingrini , Catherine Belzung , Jean-Louis Freslon , Marie-Christine Machet , Vincent Camus
Psychosomatic Medicine, 2012, 74 (1), pp.63-72. ⟨10.1097/PSY.0b013e31823a43e0⟩
Journal articles hal-03389547v1
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State and Trait Olfactory Markers of Major Depression

Marine Naudin , Wissam El-Hage , Marlène Gomes , Philippe Gaillard , Catherine Belzung
PLoS ONE, 2012, 7 (10), pp.e46938. ⟨10.1371/journal.pone.0046938⟩
Journal articles hal-02524293v1

Altered aortic vascular reactivity in the unpredictable chronic mild stress model of depression in mice

Elsa Isingrini , Alexandre Surget , Catherine Belzung , Jean-Louis Freslon , Jefferson Frisbee
Physiology & behavior, 2011, 103 (5), pp.540-546. ⟨10.1016/j.physbeh.2011.04.002⟩
Journal articles hal-03389551v1

Criteria of validity for animal models of psychiatric disorders: focus on anxiety disorders and depression

Catherine Belzung , Maël Lemoine
Biology of Mood and Anxiety Disorders, 2011, 1 (1), pp.1-9. ⟨10.1186/2045-5380-1-9⟩
Journal articles halshs-00792412v1

Early and Late-Onset Effect of Chronic Stress on Vascular Function in Mice: A Possible Model of the Impact of Depression on Vascular Disease in Aging

Elsa Isingrini , Catherine Belzung , Alexandre D’audiffret , Vincent Camus
American Journal of Geriatric Psychiatry, 2011, 19 (4), pp.335-346. ⟨10.1097/JGP.0b013e318202bc42⟩
Journal articles hal-03389115v1
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Association between Repeated Unpredictable Chronic Mild Stress (UCMS) Procedures with a High Fat Diet: A Model of Fluoxetine Resistance in Mice

Elsa Isingrini , Vincent Camus , Anne-Marie Le Guisquet , Maryse Pingaud , Séverine Devers
PLoS ONE, 2010, 5 (4), pp.e10404. ⟨10.1371/journal.pone.0010404⟩
Journal articles hal-03389112v1
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Olfactory anhedonia and negative olfactory alliesthesia in depressed patients

Boriana Atanasova , Wissam El-Hage , Claire Chabanet , Philippe Gaillard , Catherine Belzung
Psychiatry Research, 2010, 176 (2-3), pp.190-196. ⟨10.1016/j.psychres.2008.11.016⟩
Journal articles hal-02526735v1

Preserved subcortical volumes and cortical thickness in women with sexual abuse-related PTSD

Lionel Landré , Christophe Destrieux , Marion Baudry , Laurent Barantin , Jean-Philippe Cottier
Psychiatry Research: Neuroimaging, 2010, 183 (3), pp.181-186. ⟨10.1016/j.pscychresns.2010.01.015⟩
Journal articles hal-02112046v1
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Latent variables and the network perspective

Catherine Belzung , Etienne Billette de Villemeur , Mael Lemoine , Vincent Camus
Behavioral and Brain Sciences, 2010, 33 (2-3), pp.150-1. ⟨10.1017/S0140525X10000580⟩
Journal articles hal-00827754v1

Central auditory processing in aging: The dichotic listening paradigm

Caroline Hommet , K. Mondon , G. Berrut , Y. Gouyer , M. Isingrini
Journal of Nutrition, Health & Aging, 2010, 14 (9), pp.751-756. ⟨10.1007/s12603-010-0097-7⟩
Journal articles hal-02112012v1
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Free versus forced exposure to an elevated plus-maze: evidence for new behavioral interpretations during test and retest

Vincent Roy , Pierre Chapillon , Mustapha Jeljeli , Jean Caston , Catherine Belzung
Psychopharmacology, 2009, 203 (1), pp.131-41. ⟨10.1007/s00213-008-1378-2⟩
Journal articles hal-01576945v1

Endothelial dysfunction: A potential therapeutic target for geriatric depression and brain amyloid deposition in Alzheimer's disease?

Elsa Isingrini , Thomas Desmidt , Catherine Belzung , Vincent Camus
Current opinion in investigational drugs (London, England : 2000), 2009, 10 (1), pp.46-55
Journal articles hal-03389114v1
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N-3 polyunsaturated fatty acid supplementation reverses stress-induced modifications on brain monoamine levels in mice

Sylvie Vancassel , S. Leman , L. Hanonick , Stéphanie Denis , J. Roger
Journal of Lipid Research, 2008, 49 (2), pp.340-348. ⟨10.1194/jlr.M700328-JLR200⟩
Journal articles hal-02666192v1
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Olfaction: a potential cognitive marker of psychiatric disorders

Boriana Atanasova , Jérôme Graux , Wissam El-Hage , Caroline Hommet , Vincent Camus
Neuroscience and Biobehavioral Reviews, 2008, 32 (7), pp.1315 - 1325. ⟨10.1016/j.neubiorev.2008.05.003⟩
Journal articles hal-02525204v1

PTSD psychiatric patients exhibit a deficit in remembering

Géraldine Tapia , David Clarys , W. El-Hage , Catherine Belzung , Michel Isingrini
Memory, 2007, 15 (2), pp.145-153. ⟨10.1080/09658210601145965⟩
Journal articles hal-00194467v1
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Long-term impaired memory following predatory stress in mice

Wissam El-Hage , G Griebel , Catherine Belzung
Physiology & behavior, 2006, 87 (1), pp.45 - 50. ⟨10.1016/j.physbeh.2005.08.039⟩
Journal articles hal-02525076v1

Trauma-related deficits in working memory

W. El-Hage , M. Isingrini , P. Gaillard , Catherine Belzung
Cognitive Neuropsychiatry, 2006, 11 (1), pp.33-46. ⟨10.1080/13546800444000164⟩
Journal articles hal-00115203v1
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Wissam El-Hage , Sylvie Peronny , Guy Griebel , Catherine Belzung
Progress in Neuro-Psychopharmacology and Biological Psychiatry, 2004, 28 (1), pp.123 - 128. ⟨10.1016/j.pnpbp.2003.09.028⟩
Journal articles hal-02524710v1

Ethological validation and the assessment of anxiety-like behaviours: methodological comparison of classical analyses and structural approaches

François Calatayud , Catherine Belzung , A. Aubert
Behavioural Processes, 2004, 67, pp.195-206. ⟨10.1016/j.beproc.2004.04.002⟩
Journal articles hal-02682521v1

Emotional reactivity in mice may not be inherited but influenced by parents

François Calatayud , S. Coubard , Catherine Belzung
Physiology & behavior, 2004, 80 (4), pp.465-474. ⟨10.1016/j.physbeh.2003.10.001⟩
Journal articles hal-02683057v1

Myelination and motor coordination are increased in transferrin transgenic mice

M.C. Saleh , A.E. de Los Monteros , G.A. de Arriba Zerpa , I. Fontaine , O. Piaud
Journal of Neuroscience Research, 2003, 72 (5), pp.587-594
Journal articles hal-02679389v1

Environmental enrichment in BALB/c mice Effects in classical tests of anxiety and exposure to a predatory odor

Vincent Roy , Catherine Belzung , Catherine Delarue , Pierre Chapillon
Physiology & behavior, 2001, 74 (3), pp.313-320. ⟨10.1016/S0031-9384(01)00561-3⟩
Journal articles hal-01576210v1

α-Linolenic acid deficiency modifies distractibility but not anxiety and locomotion in rats during aging.

Catherine Belzung , Anne-Marie Leguisquet , Serge Barreau , Sylvie Vancassel , Sylvie Chalon
Journal of Nutrition, 1998, 128 (9), pp.1537-1542. ⟨10.1093/jn/128.9.1537⟩
Journal articles hal-02695247v1

Dietary fish oil affects monoaminergic neurotransmission and behavior in rats

Sylvie Chalon , Sylvie Vancassel , Catherine Belzung , Denis Guilloteau , Anne-Marie Leguisquet
European Journal of Nutrition, 1998, 128 (12), pp.2512-2519
Journal articles hal-02696302v1

Effect of icv or intra-raphe 5. 7-dihydroxytryptamine perfusion on state and trait anxiety in BALB/C mice

Catherine Belzung , C. Creton , Sylvie Chalon , Sylvie Vancassel
European Journal of Neuroscience, 1998, 10, pp.378
Journal articles hal-02693914v1

Découpage de l'activité d'exploration libre en sous unités de comportement chez la souris

G. Lepage , M. Reinert , Catherine Blois-Heulin , Catherine Belzung
STAL Sciences et Techniques de l'Animal de Laboratoire, 1997, 22, pp.131-139
Journal articles hal-01320522v1

Cholecystokinin receptors mediate the development of a preference for the mother by newly born lambs

Raymond Nowak , A.P. Goursaud , Frédéric Lévy , P. Orgeur , B. Schaal
Behavioral Neuroscience, 1997, 111, pp.1375-1382
Journal articles hal-02687159v1

Cholecystokinin A receptor antagonist inhibits feed memory in Japanese quail

Valérie Berthelot , Catherine Belzung , Marie-Christine Meunier-Salaün , Raymond Nowak , M. Picard
Physiology & behavior, 1996, 60 (2), pp.575-579
Journal articles hal-02697442v1

Effects of previous familiarization on novelty reactions in mice (Mus musculus)

Catherine Blois-Heulin , Catherine Belzung
Behavioural Processes, 1995, 34 (3), pp.197-212. ⟨10.1016/0376-6357(94)00064-N⟩
Journal articles hal-01320517v1

Le projet EmoFarm : une approche expérimentale de la relation entre émotions et bien-être.

Cécile Arnould , Catherine Belzung , Xavier Boivin , Ludovic Calandreau , Elodie Chaillou
Séminaire du réseau AgriBEA, Apr 2013, Ivry, France. 1 p
Conference papers hal-01173661v1

Une expérience négative dans le jeune âge modifie la sensibilité émotionnelle de l’animal, ses capacités cognitives et ses compétences sociales

Alain Boissy , Christine Leterrier , Sophie Lumineau , Catherine Belzung , Alexandra Destrez
5. Journées d'Animation Scientifique du département Phase (JAS Phase 2013), Institut National de Recherche Agronomique (INRA). UAR Département Physiologie Animale et Systèmes d'Elevage (0558)., Oct 2013, Paris, France
Conference papers hal-01173647v1

Mechanistic vs statistical exploration in preclinical research in psychiatry: challenging the received view

Etienne Billette de Villemeur , Catherine Belzung , Mael Lemoine
Adam LaCaze (dir.); Barbara Osimani (dir.). Uncertainty in Pharmacology : Epistemology, Methods and Decisions, Springer, pp.79-100, 2020
Book sections hal-02513500v1