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Cecile Legallais

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**Cécile LEGALLAIS** Date of birth : 07/03/1968 <a>cecile.legallais@utc.fr</a> **PRESENT POSITION** 2018 - : Head of Laboratory of Biomechanics and Bioengineering (joint lab Université de Technologie de Compiè(UTC)/CNRS) **APPOINTMENTS** 2006 - : Directeur de recherche CNRS (CNRS Senior researcher). Laboratory of Biomechanics and Bioengineering, Université de Technologie de Compiègne (FR) 2015 - 2018 :Associate Researcher (part time) Assistance Publique Hôpitaux de Paris (APHP) 1996 - 1997 : Post-doctoral Fellow, University of Calabria (Italy) &amp; Membrana GmbH (Germany) 1993 - 2006 : Chargé de recherche CNRS (CNRS Researcher). UTC Compiègne **ACADEMIC QUALIFICATIONS** H.D.R. 1998 “Habilitation” to supervise Ph.D. Thesis. Université de Technologie de Compiègne (FR). Blood toxins removal by membrane processes. Ph. D. 1993Université de Technologie de Compiègne (FR). Specialty : Biomedical Eng. LDL-cholesterol removal from human plasma based on cascade filtration. MS/Eng. D 1990 Ecole Nationale Supérieure de Mécanique et Aérotechnique (Poitiers) – Engineer in Fluid Mechanics **AWARDS** Bronze Medal from the CNRS, 2003. **RESEARCH ACTIVITIES : Biomechanics of Organ Supply systems** Since 1995 : **Bioartificial liver** at different scales. Encapsulation of hepatoctes in alginate beads. Design and characterization of fluidized bed bioreactor. Full extracorporeal circulation. PI of ANR TecSan SUPPLIVER (2011 -2015). WP Leader RHU Ilite (Innovations in Liver tissue Engineering) (2016-2022). PI of ANR MimLiveronChip (Organ on Chip) (2019-2023) Since 2006: **Bone and musculo-skeletal tissue engineering** based on stretching bioreactors – Mechanical and biological characterization. Since 1994: **Flow and** **Mass transfer in hemodialysis and hemodiafiltration** : Collaboration with Membrana GmbH, Fresenius Medical Care, Amiens Hospital Since 2000 : **Blood flow simulations** in 3D vessels reconstructed from medical images. **PUBLICATIONS and COMMUNICATIONS** \- **105 papers** in international journals with peer review \- 6 book chapters, **4 patents** **SYNERGISTIC ACTIVITIES** \- Past President (2019-2021) of European Society for Artificial Organs (ESAO). Formerly Governor (2005-2011), General Secretary (2011-2015), President Elect (2015-2017)&amp; President (2017-2019). \- Member of the Board of the International Federation for Artificial Organs (IFAO) \- President of the XXXVIth ESAO Congress (2009) in Compiègne, France (400 participants) \- Reviewer for Artificial Organs, Journal of Membrane Science, Biotechnology Bioengineering, Separation Science and Technology, Journal of Polymer Science, Journal of Biomechanics, Medical Engineering and Physics, Plos One, Tissue Engineering, Biomaterials. **SUPERVISION** \- 25 PhD students at UTC (22 achieved, 3 ongoing) \- 3 HDR Habilitation at UTC **TEACHING ACTIVITIES** \- Lecture on Artificial Organs (UTC) – 20h/y \- Hands on activities for engineering students (tissue engineering, hemodialysis)

Publications

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Microencapsulated Hepatocytes Differentiated from Human Induced Pluripotent Stem Cells: Optimizing 3D Culture for Tissue Engineering Applications

Marwa Hussein , Mattia Pasqua , Ulysse Pereira , Nassima Benzoubir , Jean-Charles Duclos-Vallée
Cells, 2023, 12 (6), pp.865. ⟨10.3390/cells12060865⟩
Journal articles hal-04193769v1

Generation of β-like cell subtypes from differentiated human induced pluripotent stem cells in 3D spheroids

Lisa Morisseau , Fumiya Tokito , Stéphane Poulain , Valérie Plaisance , Valerie Pawlowski
Molecular Omics, inPress, ⟨10.1039/D3MO00050H⟩
Journal articles hal-04209565v1
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Development of Liver-on-Chip Integrating a Hydroscaffold Mimicking the Liver’s Extracellular Matrix

Taha Messelmani , Anne Le Goff , Zied Souguir , Victoria Maes , Méryl Roudaut
Bioengineering, 2022, 9, ⟨10.3390/bioengineering9090443⟩
Journal articles hal-03861410v1
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Multiscale-Engineered Muscle Constructs: PEG Hydrogel Micro-Patterning on an Electrospun PCL Mat Functionalized with Gold Nanoparticles

Megane Beldjilali-Labro , Rachid Jellali , Alexander David Brown , Alejandro Garcia Garcia , Augustin Lerebours
International Journal of Molecular Sciences, 2022, 23 (1), pp.260. ⟨10.3390/ijms23010260⟩
Journal articles hal-03590377v1
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Validation of HepG2/C3A Cell Cultures in Cyclic Olefin Copolymer Based Microfluidic Bioreactors

Leire Etxeberria , Taha Messelmani , Jon Haitz Badiola , Andreu Llobera , Luis Fernandez
Polymers, 2022, 14 (21), pp.4478. ⟨10.3390/polym14214478⟩
Journal articles hal-03861408v1
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Evidence of Adult Features and Functions of Hepatocytes Differentiated from Human Induced Pluripotent Stem Cells and Self-Organized as Organoids

Antonietta Messina , Eléanor Luce , Nassima Benzoubir , Mattia Pasqua , Ulysse Pereira
Cells, 2022, 11 (3), ⟨10.3390/cells11030537⟩
Journal articles hal-03561619v1
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Investigation of the Exometabolomic Profiles of Rat Islets of Langerhans Cultured in Microfluidic Biochip

Amal Essaouiba , Rachid Jellali , Françoise Gilard , Bertrand Gakière , Teru Okitsu
Metabolites, 2022, 12 (12), pp.1270. ⟨10.3390/metabo12121270⟩
Journal articles hal-04213642v1
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Electrodialysis Can Lower the Environmental Impact of Hemodialysis

Ahmed Abarkan , Nabil Grimi , Hubert Métayer , Tarik Sqalli Houssaïni , C. Legallais
Membranes, 2022, 12 (1), pp.45. ⟨10.3390/membranes12010045⟩
Journal articles hal-03590375v1
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Monitoring mechanical stimulation for optimal tendon tissue engineering: a mechanical and biological multiscale study

Alejandro Garcia Garcia , Jean-Baptiste Perot , Megane Beldjilali-Labro , Quentin Dermigny , Marie Naudot
Journal of Biomedical Materials Research Part A, 2021, ⟨10.1002/jbm.a.37180⟩
Journal articles hal-03029652v1
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Cryogel-Integrated Biochip for Liver Tissue Engineering

Lilandra Boulais , Rachid Jellali , Ulysse Pereira , Eric Leclerc , Sidi A Bencherif
ACS Applied Bio Materials, 2021, 4 (7), pp.5617-5626. ⟨10.1021/acsabm.1c00425⟩
Journal articles hal-03322953v1
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Preclinical characterization of alginate‐Poly‐L‐Lysine encapsulated HepaRG for extracorporeal liver supply

Mattia Pasqua , Ulysse Pereira , Claire Lartigue , Jonathan Nicolas , Pascale Vigneron
Biotechnology and Bioengineering, 2021, 118 (1), ⟨10.1002/bit.27583⟩
Journal articles hal-02961888v1
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The combination of a poly‐caprolactone/nano‐hydroxyapatite honeycomb scaffold and mesenchymal stem cells promotes bone regeneration in rat calvarial defects

Marie Naudot , Alejandro Garcia Garcia , Nicolas Jankovsky , Anaïs Barre , Luciane Zabijak
Journal of Tissue Engineering and Regenerative Medicine, 2020, ⟨10.1002/term.3114⟩
Journal articles hal-02961861v1
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Cold-to-warm machine perfusion of the liver: a novel circuit for an uninterrupted combined perfusion protocol

Claire Goumard , Eric Savier , Jerome Danion , Jérôme Pelissie , Cécile Legallais
HPB, 2020, 22 (6), pp.927-933. ⟨10.1016/j.hpb.2020.04.001⟩
Journal articles hal-02884180v1
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HepaRG Self-Assembled Spheroids in Alginate Beads Meet the Clinical Needs for Bioartificial Liver

Mattia Pasqua , Ulysse Pereira , Antonietta Messina , Claire de Lartigue , Pascale Vigneron
Tissue Engineering: Parts A, B, and C, 2020, 26 (11-12), pp.613-622. ⟨10.1089/ten.tea.2019.0262⟩
Journal articles hal-02884175v1
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Development of a pancreas-liver organ-on-chip coculture model for organ-to-organ interaction studies

Amal Essaouiba , Teru Okitsu , R. Kinoshita , Rachid Jellali , Yasuyuki Sakai
Biochemical Engineering Journal, 2020, 164, pp.107783. ⟨10.1016/j.bej.2020.107783⟩
Journal articles hal-03095499v1
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Microwell-based pancreas-on-chip model enhances genes expression and functionality of rat islets of Langerhans

Amal Essaouiba , Teru Okitsu , Rachid Jellali , Marie Shinohara , Mathieu Danoy
Molecular and Cellular Endocrinology, 2020, 112, pp.110892. ⟨10.1016/j.mce.2020.110892⟩
Journal articles hal-02884096v1
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Electrospinning of biomedically relevant gradient scaffolds: From honeycomb to randomly-oriented microstructure

Christopher Leon-Valdivieso , Alejandro Garcia-Garcia , Cécile Legallais , Fahmi Bedoui
Polymer, 2020, 202, pp.122606. ⟨10.1016/j.polymer.2020.122606⟩
Journal articles hal-02884169v1
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Bioartificial liver: biomechanical considerations

L. Boulais , M. Pasqua , C. de Lartigue , R. Jellali , U. Pereira
Computer Methods in Biomechanics and Biomedical Engineering, 2019, 44th Congress of the Société de Biomécanique, 22 (sup1), pp.S370-S372. ⟨10.1080/10255842.2020.1714948⟩
Journal articles hal-03322978v1
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Nanotechnology and Bioartificial Liver Engineering. Two Rival Paths for “Converging Technology”

Xavier Guchet , Cécile Legallais
Philosophia Scientiae, 2019, 23-1, pp.121-135. ⟨10.4000/philosophiascientiae.1839⟩
Journal articles hal-02140040v1
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In Vitro Bone Cell Response to Tensile Mechanical Solicitations: Is There an Optimal Protocol?

Timothée Baudequin , Cécile Legallais , Fahmi Bedoui
Biotechnology Journal, 2019, 14 (1), pp.1800358. ⟨10.1002/biot.201800358⟩
Journal articles hal-02061207v1

Metabolomics-on-a-chip approach to study hepatotoxicity of DDT, permethrin and their mixtures

Rachid Jellali , Françoise Gilard , Vittoria Pandolfi , Audrey Legendre , Marie-José Fleury
Journal of Applied Toxicology, 2018, 38 (8), pp.1121-1134. ⟨10.1002/jat.3624⟩
Journal articles hal-02357461v1
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Bioengineering Organs for Blood Detoxification

Cécile Legallais , Dooli Kim , Sylvia Mihaila , Milos Mihajlovic , Marina Figliuzzi
Advanced Healthcare Materials, 2018, 7 (21), pp.1800430. ⟨10.1002/adhm.201800430⟩
Journal articles hal-01956818v1
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Biomaterials in Tendon and Skeletal Muscle Tissue Engineering: Current Trends and Challenges

Megane Beldjilali-Labro , Alejandro Garcia Garcia , Firas Farhat , Fahmi Bedoui , Jean-François Grosset
Materials, 2018, 11 (7), pp.1116. ⟨10.3390/ma11071116⟩
Journal articles hal-01956820v1

Mass Transfers in a Fluidized Bed Bioreactor using Alginate Beads for a Future Bioartificial Liver

B. David , E. Dore , M.Y. Jaffrin , C. Legallais
The International Journal of Artificial Organs, 2018, 27 (4), pp.284-293. ⟨10.1177/039139880402700404⟩
Journal articles hal-02149863v1
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Poly(ε-caprolactone)/Hydroxyapatite 3D Honeycomb Scaffolds for a Cellular Microenvironment Adapted to Maxillofacial Bone Reconstruction

Alejandro Garcia Garcia , Anne Hebraud , Jean-Luc Duval , Corinne Wittmer , Ludovic Gaut
ACS Biomaterials Science and Engineering, 2018, 4 (9), pp.3317-3326. ⟨10.1021/acsbiomaterials.8b00521⟩
Journal articles hal-02393845v1

Optimizing the fluidized bed bioreactor as an external bioartificial liver

Sarah Figaro , Ulysse Pereira , Hiram Rada , Nicolas Semenzato , Dominique Pouchoulin
The International Journal of Artificial Organs, 2017, 40 (4), pp.196-203. ⟨10.5301/ijao.5000567⟩
Journal articles hal-02938255v1
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Alginate-Based Cell Microencapsulation for Tissue Engineering and Regenerative Medicine

Vittoria Pandolfi , Ulysse Pereira , Murielle Dufresne , Cécile Legallais
Current Pharmaceutical Design, 2017, 23 (26), ⟨10.2174/1381612823666170609084016⟩
Journal articles hal-02938367v1

Expansion properties of alginate beads as cell carrier in the fluidized bed bioartificial liver

Seyed Danial Naghib , Vittoria Pandolfi , Ulysse Pereira , Rossella Girimonte , Efrem Curcio
Powder Technology, 2017, 316, pp.711-717. ⟨10.1016/j.powtec.2016.12.047⟩
Journal articles hal-02938369v1
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The Osteogenic and Tenogenic Differentiation Potential of C3H10T1/2 (Mesenchymal Stem Cell Model) Cultured on PCL/PLA Electrospun Scaffolds in the Absence of Specific Differentiation Medium

Timothée Baudequin , Ludovic Gaut , Marc Mueller , Angela Huepkes , Birgit Glasmacher
Materials, 2017, 10 (12), pp.1387. ⟨10.3390/ma10121387⟩
Journal articles hal-02938374v1

A new prescription model for regional citrate anticoagulation in therapeutic plasma exchanges

Sébastien Kissling , Cécile Legallais , Menno Pruijm , Daniel Teta , Bruno Vogt
BMC Nephrology, 2017, 18 (1), ⟨10.1186/s12882-017-0494-9⟩
Journal articles hal-02938371v1
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Towards the Development and Characterization of an Easy Handling Sheet-Like Biohybrid Bone Substitute

Timothée Baudequin , Fahmi Bedoui , Murielle Dufresne , Patrick Paullier , Cécile Legallais
Tissue Engineering: Parts A, B, and C, 2015, 21 (11-12), pp.1895-1905. ⟨10.1089/ten.tea.2014.0580⟩
Journal articles hal-03433119v1

Comparison of two Endovascular Treatments of a Stenosed Arteriovenous Fistula: Balloon-Angioplasty with and without Stenting

Iolanda Decorato , Zaher Kharboutly , Cécile Legallais , Anne-Virginie Salsac
The International Journal of Artificial Organs, 2014, 37 (10), pp.763-772
Journal articles hal-02019770v1

Influence of an Arterial Stenosis on the Hemodynamics Within an Arteriovenous Fistula (AVF): Comparison Before and After Balloon-Angioplasty

Iolanda Decorato , Anne-Virginie Salsac , Cécile Legallais , Mona Alimohammadi , Vanessa Diaz-Zuccarini
Cardiovascular Engineering and Technology, 2014, 5 (3), pp.233-243
Journal articles hal-02019623v1

Numerical simulation of the fluid structure interactions in a compliant patient-specific arteriovenous fistula

Iolanda Decorato , Zaher Kharboutly , Tommaso Vassallo , Justin Penrose , Cécile Legallais
International Journal for Numerical Methods in Biomedical Engineering, 2014, 30 (2), pp.143-159
Journal articles hal-02019727v1

Metabolomics-on-a-chip of hepatotoxicity induced by anticancer drug flutamide and its active metabolite hydroxyflutamide using HepG2/C3a microfluidic biochips

Leila Choucha-Snouber , Andrei Bunescu , Cécile Legallais , Céline Brochot , Marc-Emmanuel Dumas
Toxicological Sciences, 2013, 132 (1), pp.8-20. ⟨10.1093/toxsci/kfs230⟩
Journal articles ineris-00963445v1

Evaluation of seven drug metabolisms and clearances by cryopreserved human primary hepatocytes cultivated in microfluidic biochips

Régis Baudoin , Jean-Matthieu Prot , Grégory Nicolas , Jessy Brocheton , Céline Brochot
Xenobiotica, 2013, 43 (2), pp.140-152. ⟨10.3109/00498254.2012.706725⟩
Journal articles ineris-00963431v1
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Impact of Alginate Composition: From Bead Mechanical Properties to Encapsulated HepG2/C3A Cell Activities for In Vivo Implantation

Stephanie Capone , Murielle Dufresne , Mathias Rechel , Marie-José Fleury , Anne-Virginie Salsac
PLoS ONE, 2013, 8 (4), pp.e62032. ⟨10.1371/journal.pone.0062032⟩
Journal articles hal-02019744v1

Investigation of ifosfamide nephrotoxicity induced in a liver-kidney co-culture biochip.

Leila Choucha-Snouber , Caroline Aninat , Laurent Grsicom , Geoffrey Madalinski , Céline Brochot
Biotechnology and Bioengineering, 2013, 110 (2), pp.597-608. ⟨10.1002/bit.24707⟩
Journal articles inserm-00864839v1
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Human hepatic cell behavior on polysulfone membrane with double porosity level

Murielle Dufresne , Patrice Bacchin , Giulia Cerino , Jean-Christophe Remigy , Gerard Nathanael Adrianus
Journal of Membrane Science, 2013, vol. 428, pp. 454-461. ⟨10.1016/j.memsci.2012.10.041⟩
Journal articles hal-00788387v1

An appropriate selection of 3D alginate culture model for hepatic Huh-7 cell line encapsulation intended for viral studies

N.M. Tran , M. Dufresne , Gilles Duverlie , Sandrine Castelain , Christian Défarge
Tissue Engineering: Parts A, B, and C, 2013, 19 (1-2), pp.103-113. ⟨10.1089/ten.tea.2012.0139⟩
Journal articles insu-00723045v1
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Predictive toxicology using systemic biology and liver microfluidic "on chip" approaches: Application to acetaminophen injury

Jean-Matthieu Prot , Andrei Bunescu , Bénédicte Elena-Herrmann , Caroline Aninat , Leila Choucha Snouber
Toxicology and Applied Pharmacology, 2012, 259 (3), pp.270-280. ⟨10.1016/j.taap.2011.12.017⟩
Journal articles hal-00699551v1

Metabolomics-on-a-Chip and Predictive Systems Toxicology in Microfluidic Bioartificial Organs

Laetitia Shintu , Régis Baudoin , Vincent Navratil , Jean-Matthieu Prot , Clément Pontoizeau
Analytical Chemistry, 2012, 84 (4), pp.1840-1848. ⟨10.1021/ac2011075⟩
Journal articles hal-00699575v1

Integrated proteomic and transcriptomic investigation of the acetaminophen toxicity in liver microfluidic biochip.

J.M. Prot , A.S. Briffaut , F. Letourneur , P. Chafey , F. Merlier
PLoS ONE, 2011, 6 (8), pp.e21268. ⟨10.1371/journal.pone.0021268⟩
Journal articles hal-00637409v1

A cocktail of metabolic probes demonstrates the relevance of primary human hepatocyte cultures in a microfluidic biochip for pharmaceutical drug screening

Jean-Matthieu Prot , Orianne Videau , Céline Brochot , Cécile Legallais , Henri Benech
International Journal of Pharmaceutics, 2011, 108 (1-2), pp.67-75. ⟨10.1016/j.ijpharm.2011.01.054⟩
Journal articles ineris-00963290v1

Improvement of HepG2/C3a cell functions in a microfluidic biochip.

Jean Matthieu Prot , Caroline Aninat , Laurent Griscom , Florence Razan , Céline Brochot
Biotechnology and Bioengineering, 2011, 108 (7), pp.1704-15. ⟨10.1002/bit.23104⟩
Journal articles hal-00740224v1

ENDOCOM: Implantable wireless pressure sensor for the follow-up of abdominal aortic aneurysm stented

Olivier Romain , Johan Mazeyrat , Patrick Garda , Hakeim Talleb , David Lautru
Innovation and Research in BioMedical engineering, 2011, 32 (3), pp.163 - 168. ⟨10.1016/j.irbm.2011.01.017⟩
Journal articles hal-00665334v1

Analysis of the mass transfers in an artificial kidney microchip

A. Ould-Dris , P. Paullier , Laurent Griscom , Cécile Legallais , E. Leclerc
Journal of Membrane Science, 2010, 352, pp.116-125. ⟨10.1016/j.memsci.2010.02.007⟩
Journal articles hal-00592403v1

Prédiction de la toxicocinétique in vivo de substances chimiques à partir de données in vitro et de modèles QSAR

Dany Habka , Alexandre R.R. Pery , Cécile Legallais , Céline Brochot
Environnement, Risques & Santé, 2010, 9 (6), pp.489-501
Journal articles ineris-00963259v1

Numerical and experimental study of blood flow through a patient-specific arteriovenous fistula used for hemodialysis

Zaher Kharboutly , Valérie Deplano , Eric Bertrand , Cécile Legallais
Medical Engineering & Physics, 2010, 32, pp.111-118. ⟨10.1016/j.medengphy.2009.10.013⟩
Journal articles hal-00429960v1

Artificial and bioartificial liver devices: present and future.

B. Carpentier , A. Gautier , C. Legallais
Gut, 2009, 58 (12), pp.1690-1702. ⟨10.1136/gut.2008.175380⟩
Journal articles hal-00437697v1

Alginate-encapsulated HepG2 Cells in a Fluidized Bed Bioreactor Maintain Function in Human Liver Failure Plasma

Sam Coward , Cécile Legallais , Bertrand David , Michael Thomas , Ying Foo
Artificial Organs, 2009, 33 (12), pp.1117-1126. ⟨10.1111/j.1525-1594.2009.00821.x⟩
Journal articles hal-02149842v1

Hollow fiber bioartificial liver: Physical and biological characterization with C3A cells.

A. Gautier , A. Ould-Dris , M. Dufresne , P. Paullier , B. von Harten
Journal of Membrane Science, 2009, 341 ((1-2)), pp.203-213
Journal articles hal-00437709v1

In vitro tests and modelization of bicarbonate kinetics and mass transfers during online hemodiafiltration.

H. Morel , M.Y. Jaffrin , P. Paullier , C. Legallais
The International Journal of Artificial Organs, 2009, 32, pp.482-491
Journal articles hal-00437233v1

Les dispositifs de suppléance hépatique.

A. Gautier , C. Legallais
Réanimation, 2009, 18 (5), pp.413-419
Journal articles hal-00437800v1

The place of adsorption and biochromatography in extracorporeal liver support systems.

C. Legallais , A. Gautier , M. Dufresne , B. Carpentier , R. Baudoin
Journal of Chromatography B - Analytical Technologies in the Biomedical and Life Sciences, 2008, 961, pp.171-176
Journal articles hal-00339871v1

hree-dimensional growth of human hepatoma C3A cells within alginate beads for fluidized bioartificial liver.

A. Kinasiewicz , A. Gautier , D. Lewinska , A. Smietanka , C. Legallais
The International Journal of Artificial Organs, 2008, 31, pp.340 Â- 347
Journal articles hal-00339867v1

Solid–liquid mass transfers in an airlift reactor incorporating alginate beads for the application as a bioartificial liver

S. Demming , A. Gautier , C. Legallais , A. Ould-Dris
Chemical Engineering and Processing: Process Intensification, 2008, 47 (12), pp.2370-2378. ⟨10.1016/j.cep.2008.01.013⟩
Journal articles hal-00336365v1

Culture of C3A Cells in Alginate Beads for Fluidized Bed Bioartificial Liver.

A. Kinasiewicz , A. Gautier , D. Lewinska , J. Bukowski , C. Legallais
Transplantation Proceedings, 2007, 39 (9), pp.2911-2913. ⟨10.1016/j.transproceed.2007.08.062⟩
Journal articles hal-00282673v1

A theoretical study of oxygen transfer including cell necrosis for the design of a bioartificial pancreas

J.L. Dulong , C. Legallais
Biotechnology and Bioengineering, 2007, 96, pp.990-998. ⟨10.1002/bit.21140⟩
Journal articles hal-00282668v1

Development of a renal microchip for in vitro distal tubule models.

R. Baudoin , L. Griscom , M. Monge , C. Legallais , E. Leclerc
Biotechnol. Prog, 2007, 23, pp.1245-1253
Journal articles hal-00196149v1

Investigations into the relationship between hemodynamics and vascular alterations in an established arteriovenous fistula.

Z. Kharboutly , M. Fenech , J.M. Treutenaere , I. Claude , C. Legallais
Medical Engineering & Physics, 2007, 29, pp.999-1007
Journal articles hal-00282672v1

Générateurs d'hémodialyse : état du marché français.

S. Merlo , A. Donadey , B. Coevoet , C. Legallais
ITBM RBM, 2007, 28, pp.150-168
Journal articles hal-00282676v1

Selective control of liver and kidney cells migration during organotypic cocultures inside fibronectin-coated rectangular silicone microchannels.

E. Leclerc , R. Baudoin , Anne Corlu , L. Griscom , J.L. Duval
Biomaterials, 2007, 28, pp.1820-1829
Journal articles hal-00172298v1

Trends in the development of microfluidic cell biochips for in vitro hepatotoxicity.

R. Baudoin , Anne Corlu , L. Griscom , C. Legallais , E. Leclerc
Toxicol. In vitro, 2007, 21, pp.535-544
Journal articles hal-00172268v1

Perfusion culture of mammalian cells in microfluidic environments for tissue engineering applications 

Eric Leclerc , Bertrand David , Laurent Griscom , Bruno Lepioufle , Yasuyuki Sakai
La Houille Blanche - Revue internationale de l'eau, 2006, 3, pp.56-59. ⟨10.1051/lhb:200603008⟩
Journal articles hal-02149903v1

Perfusion culture of mammalian cells in microfluidic environments for tissue engineering applications.

E. Leclerc , B. David , L. Griscom , Bruno Le Pioufle , T. Fujii
La Houille Blanche - Revue internationale de l'eau, 2006, 3, pp.56-59
Journal articles hal-00090259v1

Study of Osteoblastic Cells in a Microfluidic Environment

E. Leclerc , B. David , L Griscom , Bruno Le Pioufle , T. Fujii
Biomaterials, 2006, 27 (4), pp.558-595
Journal articles hal-00778216v1

Mechanical properties of alginate beads hosting hepatocytes in a fluidized bed bioreactor.

B. David , L. Barbe , C. Legallais , D. Barthès-Biesel
The International Journal of Artificial Organs, 2006, 29, pp.756-763
Journal articles hal-00090597v1

Guidance of liver and kidney organotypic cultures inside rectangular silicone microchannels.

E. Leclerc , A. Corlu , L. Griscom , R. Baudoin , C. Legallais
Biomaterials, 2006, 27, pp.4109-4119
Journal articles hal-00090178v1

Mechanical properties of alginate beads hosting hepatocytes in a fluidized bed bioreactor.

C David , L. Barbe , D. Barthès-Biesel , C. Legallais
The International Journal of Artificial Organs, 2006, 29 (8), pp.756-63
Journal articles hal-02149847v1

Study of osteoblastic cells in a microfluidic environment

E. Leclerc , B. David , L. Griscom , Bruno Le Pioufle , T. Fujii
Biomaterials, 2006, 27 (4), pp.586-595. ⟨10.1016/j.biomaterials.2005.06.002⟩
Journal articles hal-02149853v1

What are the relevant parameters for the geometrical optimization of an implantable bioartificial pancreas ?

J.L. Dulong , C. Legallais
Journal of Biomechanical Engineering, 2005, 127 (7), pp.1054-1061. ⟨10.1115/1.2073407⟩
Journal articles hal-00017278v1

In vitro assessment of encapsulated C3A hepatocytes functions in a fluidized bed bioreactor

B. David , M. M. Dufresne , M. Nagel , C. Legallais
Biotechnology Progress, 2004, 20 (4), pp.1204-1212. ⟨10.1021/bp034301z⟩
Journal articles hal-02149856v1

Bioartificial livers (BAL): current technological aspects and future developments

C. Legallais , B David , E. Dore
Journal of Membrane Science, 2001, 181 (1), pp.81-95. ⟨10.1016/S0376-7388(00)00539-1⟩
Journal articles hal-02149872v1

Development and validation of a bioartificial liver device with fluidized bed bioreactors hosting alginate-encapsulated hepatocyte spheroids

S. Figaro , Ulysse Pereira , H. Rada , N. Semenzato , D. Pouchoulin
2015 37th Annual International Conference of the IEEE Engineering in Medicine and Biology Society (EMBC), Aug 2015, Milan, France. pp.1335-1338, ⟨10.1109/embc.2015.7318615⟩
Conference papers hal-03411623v1

RFID implantable pressure sensor for the follow-up of abdominal aortic aneurysm stented

Olivier Romain , Johan Mazeyrat , Patrick Garda , Hakeim Talleb , David Lautru
IEEE DTIS 2011 : 6th International conference on Design & Technology of Integrated Systems in nanoscale era, Apr 2011, Athens, Greece. pp.1-6, ⟨10.1109/DTIS.2011.5941418⟩
Conference papers hal-00600948v1

Calibration of PBPK models based on in vivo and in vitro data to describe complex biotransformation processes

Dany Habka , Alexandre R.R. Pery , C. Aninat , A. Corlu , C. Guguen-Guillouzo
12. International Congress of Toxicology (IUTOX 2010), Jul 2010, Barcelone, Spain
Conference papers ineris-00970650v1

Liver-kidney microfluidic bioreactor for cell co-culture in drug studies

L. Choucha Snouber , Laurent Griscom , Pe Poleni , Florence Razan , Céline Brochot
MICROTAS, Oct 2010, GRONINGEN, Netherlands. pp.0328
Conference papers hal-00756580v1

Toxicologie predictive: les voies du futur

Ph Detilleux , L Vallier , C Legallais , E Leclerc , M Prot J
Congrès de la SPTC - Société de Pharmaco-Toxicologie Cellulaire, May 2010, Paris, France
Conference papers hal-01122677v1

Comparison of the growth kinetics of hepatocarcinoma cells in a microfluidic bioreactor and Petri dishes

J.M. Prot , R. Baudoin , L. Griscom , C. Legallais , E. Leclerc
MMB 2009, Apr 2009, Québec, Canada
Conference papers hal-00457134v1

Use of a liver biochip as a tool in toxicological study.

J.M. Prot , R. Baudoin , L. Griscom , C. Legallais , E. Leclerc
XXXVI Annual meeting European Society for Artificial Organs. ESAO 2009, Sep 2009, Compiègne, France
Conference papers hal-00457136v1

Microfluidic biochip for in vitro toxicity analysis

R. Baudoin , J.M. Prot , C. Legallais , E. Leclerc
ESAO 2009, Sep 2009, Compiègne, France
Conference papers hal-00456973v1

Cell Micro-Encapsulation and Bioartificial Liver.

C. Legallais , A. Gautier , B. Carpentier , Q. Vu Dinh , M. Dufresne
8th World Biomaterials Congress, May 2008, Amsterdam, Netherlands
Conference papers hal-00345819v1

Bicarbonate and urea kinetics modeling during hemodialysis and online postdilution hemodiafiltration.

H. Morel , M.Y. Jaffrin , J. Vienken , C. Legallais
ESAO 2008, XXXV Annual Meeting European Society for Artificial Organs, Sep 2008, Genève, Switzerland. pp.65
Conference papers hal-00345030v1

In vitro bicarbonate and urea kinetics during hemodialysis and online hemodiafiltration.

H. Morel , M.Y. Jaffrin , C. Legallais , J. Vienken
33ème Congrès de la Société de Biomécanique, Sep 2008, Compiègne, France. pp.167
Conference papers hal-00344995v1

Flow and mass transfer modeling for tissue engineering applications.

B. Carpentier , A. Gautier , P. Paullier , A. Ould-Dris , P. Layrolle
33ème Congrès de la Société de Biomécanique, Sep 2008, Compiègne, France. pp.53-55
Conference papers hal-00345817v1

Development of a cellular biochip mimicking in vitro organs for chronic toxicity analysis.

R. Baudoin , L. Griscom , A. Corlu , P. Layrolle , C. Legallais
Transducers'07, 14th International Conference on Solid-State Sensors, actuators and Microsystems, Jun 2007, Lyon, France
Conference papers hal-00289965v1

An example of bioartificial organ : combination of hepatocytes microencapsulation and fluidized bed technology for extracorporeal liver support.

A. Gautier , M. Dufresne , B. Carpentier , P. Paullier , C. Legallais
International Congress on “Biochromatography and Nanobiotechnologies", Feb 2007, Vellore, India
Conference papers hal-00289993v1

Bioartificial liver based on hollow fiber membrane : physical and biological characterization at micro scale level.

A. Gautier , H.D. Lemke , B. von Harten , M. Dufresne , C. Legallais
34th ESAO Congress, Sep 2007, Krems, Austria
Conference papers hal-00290030v1

Production of bone substitutes in bioreactors : Modeling and culture of bone marrow stem cells.

B. Carpentier , J. Sohier , P. Layrolle , C. Legallais
34th ESAO Congress, Sep 2007, Krems, Austria
Conference papers hal-00289975v1

Caractérisation des écoulements dans une fistule artério veineuse. Comparaison numérique expérimentale.

Zaher Kharboutly , Cécile Legallais , Eric Bertrand , Valérie Deplano
Journées scientifiques du GDR2760 : Interactions fluide structure biologiques, May 2007, Marseille, France
Conference papers hal-00456057v1

Modélisations numérique et expérimentale des écoulements sanguins dans une fistule artério-veineuse.

Z. Kharboutly , C. Legallais , V. Deplano , E. Bertrand
8ème Colloque National en Calcul des Structures, May 2007, Giens, France
Conference papers hal-00294647v1

Modélisations numérique et expérimentale des écoulements sanguins dans une fistule artério veineuse

Zaher Kharboutly , Cécile Legallais , Valérie Deplano , Eric Bertrand
8ème Colloque National en calcul des structures, May 2007, Giens, France
Conference papers hal-00455960v1

Validation des procédures de maillage pour l'étude des écoulements sanguins dans une fistule artério-veineuse réelle.

Z. Kharboutly , J.M. Treutenaere , I. Claude , M. Fenech , C. Legallais
18ème Congrès Français de Mécanique, Aug 2007, Grenoble, France
Conference papers hal-00294651v1

Three dimensional growth of hepatic cells in alginate beads. Studies of beads optimization for fluidized bed bioreactor.

A. Kinasiewicz , A. Gautier , D. Lewinska , M. Dufresne , A. Smietanka
34th ESAO Congress, Sep 2007, Krems, Austria
Conference papers hal-00290051v1
Image document

Modélisations numérique et expérimentale des écoulements sanguins dans une fistule artério-veineuse

Zaher Kharboutly , Cécile Legallais , Valérie Deplano , Eric Bertrand
8e Colloque national en calcul des structures, CSMA, May 2007, Giens, France
Conference papers hal-01507578v1

In vitro optimization of alginate bead production for hepatocytes encapsulation in the fluidized bed bioartificial liver.

A. Gautier , A. Kinasiewicz , B. Carpentier , D. Lewinska , P. Paullier
5th World Congress of Biomechanics, Jul 2006, Munich, Germany
Conference papers hal-00118148v1

Development of a microfluidic devices for in vitro liver model.

R. Baudoin , L. Griscom , A. Corlu , C. Legallais , E. Leclerc
5th World Congress of Biomechanics, Jul 2006, Munich, Germany
Conference papers hal-00116596v1

Numerical Simulation of Blood Flow in a side-to-end fistula for hemodialysis.

Z. Kharboutly , J.M. Treutenaere , M. Fenech , T. Chambon , I. Claude
5th World Congress of Biomechanics, Jul 2006, Munich, Germany
Conference papers hal-00118280v1

Liver organotypic chick embryo cultures on silicone microchannels.

E. Leclerc , A. Corlu , L. Griscom , R. Baudoin , C. Legallais
ESB 20th European Conference on Biomaterials, Sep 2006, Nantes, France
Conference papers hal-00118400v1

Development of a renal microfluidic device for future in vitro kidney model reconstruction.

R. Baudoin , L. Griscom , C. Legallais , E. Leclerc
XXXIII ESAO Congress, Jun 2006, Umea, Sweden
Conference papers hal-00116598v1

Application of cells microencapsulation for bioartificial liver in fluidized bed bioreactor.

A. Gautier , B. Carpentier , M. Dufresne , P. Paullier , C. Legallais
14th International Workshop on Bioencapsulation, Oct 2006, Lausanne, Switzerland
Conference papers hal-00118146v1

Activity of cells within alginate beads produced for fluidized bed bioreactor (bioartificial liver).

A. Kinasiewicz , A. Gautier , D. Lewinska , M. Dufresne , P. Paullier
XXIII ESAO Congress, Jun 2006, Umea, Sweden
Conference papers hal-00118286v1

Mass transfer studies in a model of fluidized bed bioartificial liver.

B. Carpentier , A. Gautier , P. Paullier , C. Legallais
XXXIII ESAO Congress, Jun 2006, Umea, Sweden
Conference papers hal-00118114v1

PDMS microdevices as new supports for in vitro bioartificial organs.

R. Baudoin , L. Griscom , C. Legallais , E. Leclerc
XXXIII ESAO Congress, Jun 2006, Umea, Sweden
Conference papers hal-00116600v1

Human liver cells in a pilot-scale fluidised-bed bioreactor maintain performance in human liver failure plasma making them suitable for a bioartificial liver.

S. Coward , C. Legallais , A. Gautier , P. Paullier , M. Thomas
5th World Congress of Biomechanics, Jul 2006, Munich, Germany
Conference papers hal-00118127v1

Blood flow simulation in an arteriovenous fistula.

Z. Kharboutly , M. Fenech , J.M. Treutenaere , I. Claude , C. Legallais
XXth Congress International Society for Biomechanics, 2005, Cleveland, Ohio, United States
Conference papers hal-00019375v1

Hydrodynamic behaviour of several types of fluidized bed bioreactor used in a bioartificial liver.

R. Baudoin , A. Gautier , S.M. Coward , B. David , H.J.F. Hodgson
XXXII ESAO Congress, 2005, Bologne, Italy
Conference papers hal-00018719v1

Behaviour of osteoblast-like cells in cellular microdevices

E. Leclerc , B. David , R. Warocquier-Clerout , L. Griscom , Bruno Le Pioufle
Micro Total Analysis Systems 2004, Vol 1, 2005, Netherlands. pp.396-398
Conference papers hal-00795188v1

CFD modeling of unsteady blood flow in a arteriovenous fistula reconstructed from angioscanner.

Z. Kharboutly , M. Fenech , J.M. Treutenaere , I. Claude , C. Legallais
30ème Congrès de la Société de Biomécanique. In Computer Methods in Biomechanics and Biomedical Engineering, 8,, 2005, Bruxelles, Belgium. pp.161-162
Conference papers hal-00019374v1

Investigation of Human Hepatoma cell line microfluidic devices.

E. Leclerc , L. Griscom , Bruno Le Pioufle , C. Guguen-Guillouzo , A. Corlu
3rd annual International IEEE EMBS special topic conference on microtechnologies in medicine and biology., 2005, Oahu, Hawaii, United States
Conference papers hal-00019381v1

Are Co-Culture Approaches Able to Improve Biological Functions of Bioartificial Livers?

V. Pandolfi , Ulysse Pereira , Murielle Dufresne , C. Legallais
Biomedical Membranes and (Bio)Artificial Organs, 2, WORLD SCIENTIFIC, pp.179-210, 2018, 978-981-3223-97-4. ⟨10.1142/9789813223974_0007⟩
Book sections hal-03411616v1

Hemodynamics inside autologous arteriovenous fistulas.

Iolanda Decorato , Zaher Kharboutly , Cécile Legallais , Anne-Virginie Salsac
Medical Devices Design in Cardiovascular Applications., 2013
Book sections hal-02019796v1

Microencapsulation d'hépatocytes pour le développement d'un système de suppléance hépatique.

A. Gautier , B. Carpentier , C. Legallais
Coord. Vandamme, Poncelet, Subra-Paternault. Microencapsulation : des sciences aux technologies, Lavoisier Editions Tec&Doc, pp.295-312, 2007
Book sections hal-00289971v1

Plasma Separation and Purification by Membrane

M.Y. Jaffrin , C. Legallais
Encyclopedia of Biomedical Engineering, Wiley-Interscience, vol. 5, pp.2795-2804, 2006
Book sections hal-00096787v1