Cecile Legallais
Présentation
Cécile LEGALLAIS Date of birth : 07/03/1968 PRESENT POSITION 2018 - : Head of Laboratory of Biomechanics and Bioengineering (joint lab Université de Technologie de Compiè(UTC)/CNRS) APPOINTMENTS 2006 - : Directeur de recherche CNRS (CNRS Senior researcher). Laboratory of Biomechanics and Bioengineering, Université de Technologie de Compiègne (FR) 2015 - 2018 :Associate Researcher (part time) Assistance Publique Hôpitaux de Paris (APHP) 1996 - 1997 : Post-doctoral Fellow, University of Calabria (Italy) & Membrana GmbH (Germany) 1993 - 2006 : Chargé de recherche CNRS (CNRS Researcher). UTC Compiègne ACADEMIC QUALIFICATIONS H.D.R. 1998 “Habilitation” to supervise Ph.D. Thesis. Université de Technologie de Compiègne (FR). Blood toxins removal by membrane processes. Ph. D. 1993Université de Technologie de Compiègne (FR). Specialty : Biomedical Eng. LDL-cholesterol removal from human plasma based on cascade filtration. MS/Eng. D 1990 Ecole Nationale Supérieure de Mécanique et Aérotechnique (Poitiers) – Engineer in Fluid Mechanics AWARDS Bronze Medal from the CNRS, 2003. RESEARCH ACTIVITIES : Biomechanics of Organ Supply systems Since 1995 : Bioartificial liver at different scales. Encapsulation of hepatoctes in alginate beads. Design and characterization of fluidized bed bioreactor. Full extracorporeal circulation. PI of ANR TecSan SUPPLIVER (2011 -2015). WP Leader RHU Ilite (Innovations in Liver tissue Engineering) (2016-2022). PI of ANR MimLiveronChip (Organ on Chip) (2019-2023) Since 2006: Bone and musculo-skeletal tissue engineering based on stretching bioreactors – Mechanical and biological characterization. Since 1994: Flow and Mass transfer in hemodialysis and hemodiafiltration : Collaboration with Membrana GmbH, Fresenius Medical Care, Amiens Hospital Since 2000 : Blood flow simulations in 3D vessels reconstructed from medical images. PUBLICATIONS and COMMUNICATIONS - 105 papers in international journals with peer review - 6 book chapters, 4 patents SYNERGISTIC ACTIVITIES - Past President (2019-2021) of European Society for Artificial Organs (ESAO). Formerly Governor (2005-2011), General Secretary (2011-2015), President Elect (2015-2017)& President (2017-2019). - Member of the Board of the International Federation for Artificial Organs (IFAO) - President of the XXXVIth ESAO Congress (2009) in Compiègne, France (400 participants) - Reviewer for Artificial Organs, Journal of Membrane Science, Biotechnology Bioengineering, Separation Science and Technology, Journal of Polymer Science, Journal of Biomechanics, Medical Engineering and Physics, Plos One, Tissue Engineering, Biomaterials. SUPERVISION - 25 PhD students at UTC (22 achieved, 3 ongoing) - 3 HDR Habilitation at UTC TEACHING ACTIVITIES - Lecture on Artificial Organs (UTC) – 20h/y - Hands on activities for engineering students (tissue engineering, hemodialysis)
Publications
Publications
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Triphasic electrospun scaffold with dynamic cells coculture for tissue engineering of bone-tendon-muscle junctionsESAO-IFAO Congress, ESAO-IFAO, Sep 2024, Aachen (Aix la Chapelle), Germany. pp.421-565, ⟨10.1177/03913988241279540⟩ |
Investigation of Oleic Acid, Palmitic Acid and their mixture on the development of hepatic steatosis using liver-on-chip technology49th ESAO Congress, Aug 2023, Bergamo, Italy |
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Advancements towards artificial organsESOT Congres, European Society for Orthotopic Transplantation, Sep 2023, Athènes, Greece |
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Philosophy of science, a tool to face engineered liver challengesTermis –EU 2022, Jun 2022, Krakow, Poland |
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Contrôle découlement et suivi de prolifération dans des biopuces hépatiques25`eme Congrès Français de Mécanique, Aug 2022, Nantes, France |
Membranes and Porous Scaffolds for Bioartificial OrgansEuroMembrane 2022, Nov 2022, Sorrento (Italie), Italy |
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Evaluation of treatment strategies for acute liver failure based on a perfused bed bioreactor9th World Congress of Biomechanics, Jul 2022, Tai pei, Taiwan |
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Development of liver-on-chip model integrating LSEC barrier and hepatocytes organoids for toxicity applicationThe 1st edition of the MicroPhysio conference on "Micro-physiological models: From organoids to organs-on-chip", Apr 2022, Cargese (Corse), France |
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Modulating mechanical and biological parameters to investigate phenotypic changes in human liver sinusoidal endothelial cells2021 TERMIS 6th World Congress, Nov 2021, Maastricht, Netherlands |
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Development of an advanced liver organ-on-chip integrating hydroscaffold mimicking cell matrix47th ESAO Congress, Sep 2021, London (U.K.), United Kingdom |
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Can a new perfused dynamic bioreactor hosting heparg in alginate-poly-l-lysine beads meet the clinical needs for extracorporeal liver supply?47th ESAO congress, Sep 2021, London, United Kingdom |
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3D liver-on-chip model integrating hydrogel mimicking cell matrixTERMIS 6th World Congress, Nov 2021, Maastricht (Netherland), Netherlands |
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Ethical and epistemological questions in (bio)artificial organsJoint IFAO-JSAO Congress, Japanese Society for Artificial Organs, Nov 2019, Osaka (JP), Japan |
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Cryogel integrated microchip : towards a human 3D model of liver cancerCancer Cells-on-Chip 2, Mar 2019, Lyon, France |
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The benefits of multiscale approaches in Liver Tissue Engineering46th Congress European Society for Artificial Organs, ESAO, Sep 2019, Hannover - Germany, Germany |
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Investigation of the Behavior of Rat Pancreatic Islets in an Organ-On-Chip ModelIFAO-JSAO Congress, Nov 2019, Osaka (JP), Japan |
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Bioartificial Liver: What's next ?ESOT Congress, European Society for Orthotopic Transplantation, Sep 2019, Copenhagen, Denmark |
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Liver on chip platform: key questions following 15 years of developmentInternational MicroNanoconference, Dec 2018, Amsterdam, Netherlands |
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Electrically Conductive Multi Dimensional Scaffolds With Controllable Architecture For Skeletal Muscle Engineering5th TERMIS World Congress, Aug 2018, Kyoto (Japan), Japan |
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Mechanical stimulation monitoring towards optimal tendon tissue reconstructionXLV ESAO Congress, Sep 2018, Madrid, Spain |
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Development and validation of a bioartificial liver device with fluidized bed bioreactors hosting alginate-encapsulated hepatocyte spheroids2015 37th Annual International Conference of the IEEE Engineering in Medicine and Biology Society (EMBC), Aug 2015, Milan, France. pp.1335-1338, ⟨10.1109/embc.2015.7318615⟩ |
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Liver-kidney microfluidic bioreactor for cell co-culture in drug studiesMICROTAS, Oct 2010, GRONINGEN, Netherlands. pp.0328 |
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RFID implantable pressure sensor for the follow-up of abdominal aortic aneurysm stentedIEEE DTIS 2011 : 6th International conference on Design & Technology of Integrated Systems in nanoscale era, Apr 2011, Athens, Greece. pp.1-6, ⟨10.1109/DTIS.2011.5941418⟩ |
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Numerical study of the influence of wall compliance on the hemodynamics in a patient-specific arteriovenous fistulaCFM 2011 - 20ème Congrès Français de Mécanique, Aug 2011, Besançon, France |
Toxicologie predictive: les voies du futurCongrès de la SPTC - Société de Pharmaco-Toxicologie Cellulaire, May 2010, Paris, France |
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Calibration of PBPK models based on in vivo and in vitro data to describe complex biotransformation processes12. International Congress of Toxicology (IUTOX 2010), Jul 2010, Barcelone, Spain |
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Comparison of the growth kinetics of hepatocarcinoma cells in a microfluidic bioreactor and Petri dishesMMB 2009, Apr 2009, Québec, Canada |
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Microfluidic biochip for in vitro toxicity analysisESAO 2009, Sep 2009, Compiègne, France |
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Use of a liver biochip as a tool in toxicological study.XXXVI Annual meeting European Society for Artificial Organs. ESAO 2009, Sep 2009, Compiègne, France |
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Flow and mass transfer modeling for tissue engineering applications.33ème Congrès de la Société de Biomécanique, Sep 2008, Compiègne, France. pp.53-55 |
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Bicarbonate and urea kinetics modeling during hemodialysis and online postdilution hemodiafiltration.ESAO 2008, XXXV Annual Meeting European Society for Artificial Organs, Sep 2008, Genève, Switzerland. pp.65 |
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In vitro bicarbonate and urea kinetics during hemodialysis and online hemodiafiltration.33ème Congrès de la Société de Biomécanique, Sep 2008, Compiègne, France. pp.167 |
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Cell Micro-Encapsulation and Bioartificial Liver.8th World Biomaterials Congress, May 2008, Amsterdam, Netherlands |
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Modélisations numérique et expérimentale des écoulements sanguins dans une fistule artério veineuse8ème Colloque National en calcul des structures, May 2007, Giens, France |
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Modélisations numérique et expérimentale des écoulements sanguins dans une fistule artério-veineuse.8ème Colloque National en Calcul des Structures, May 2007, Giens, France |
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Modélisations numérique et expérimentale des écoulements sanguins dans une fistule artério-veineuse8e Colloque national en calcul des structures, CSMA, May 2007, Giens, France |
Three dimensional growth of hepatic cells in alginate beads. Studies of beads optimization for fluidized bed bioreactor.34th ESAO Congress, Sep 2007, Krems, Austria |
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An example of bioartificial organ : combination of hepatocytes microencapsulation and fluidized bed technology for extracorporeal liver support.International Congress on “Biochromatography and Nanobiotechnologies", Feb 2007, Vellore, India |
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Bioartificial liver based on hollow fiber membrane : physical and biological characterization at micro scale level.34th ESAO Congress, Sep 2007, Krems, Austria |
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Development of a cellular biochip mimicking in vitro organs for chronic toxicity analysis.Transducers'07, 14th International Conference on Solid-State Sensors, actuators and Microsystems, Jun 2007, Lyon, France |
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Validation des procédures de maillage pour l'étude des écoulements sanguins dans une fistule artério-veineuse réelleCFM 2007 - 18ème Congrès Français de Mécanique, Aug 2007, Grenoble, France |
Caractérisation des écoulements dans une fistule artério veineuse. Comparaison numérique expérimentale.Journées scientifiques du GDR2760 : Interactions fluide structure biologiques, May 2007, Marseille, France |
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Production of bone substitutes in bioreactors : Modeling and culture of bone marrow stem cells.34th ESAO Congress, Sep 2007, Krems, Austria |
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Application of cells microencapsulation for bioartificial liver in fluidized bed bioreactor.14th International Workshop on Bioencapsulation, Oct 2006, Lausanne, Switzerland |
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Development of a renal microfluidic device for future in vitro kidney model reconstruction.XXXIII ESAO Congress, Jun 2006, Umea, Sweden |
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Liver organotypic chick embryo cultures on silicone microchannels.ESB 20th European Conference on Biomaterials, Sep 2006, Nantes, France |
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Human liver cells in a pilot-scale fluidised-bed bioreactor maintain performance in human liver failure plasma making them suitable for a bioartificial liver.5th World Congress of Biomechanics, Jul 2006, Munich, Germany |
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PDMS microdevices as new supports for in vitro bioartificial organs.XXXIII ESAO Congress, Jun 2006, Umea, Sweden |
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Mass transfer studies in a model of fluidized bed bioartificial liver.XXXIII ESAO Congress, Jun 2006, Umea, Sweden |
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Activity of cells within alginate beads produced for fluidized bed bioreactor (bioartificial liver).XXIII ESAO Congress, Jun 2006, Umea, Sweden |
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Development of a microfluidic devices for in vitro liver model.5th World Congress of Biomechanics, Jul 2006, Munich, Germany |
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In vitro optimization of alginate bead production for hepatocytes encapsulation in the fluidized bed bioartificial liver.5th World Congress of Biomechanics, Jul 2006, Munich, Germany |
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Numerical Simulation of Blood Flow in a side-to-end fistula for hemodialysis.5th World Congress of Biomechanics, Jul 2006, Munich, Germany |
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Blood flow simulation in an arteriovenous fistula.XXth Congress International Society for Biomechanics, 2005, Cleveland, Ohio, United States |
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CFD modeling of unsteady blood flow in a arteriovenous fistula reconstructed from angioscanner.30ème Congrès de la Société de Biomécanique. In Computer Methods in Biomechanics and Biomedical Engineering, 8,, 2005, Bruxelles, Belgium. pp.161-162 |
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Behaviour of osteoblast-like cells in cellular microdevicesMicro Total Analysis Systems 2004, Vol 1, 2005, Netherlands. pp.396-398 |
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Hydrodynamic behaviour of several types of fluidized bed bioreactor used in a bioartificial liver.XXXII ESAO Congress, 2005, Bologne, Italy |
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Microfluidic and Organ-on-a-chip-based Technologies for Diabetes Therapy and ResearchNanotechnology for Diabetes Management, Royal Society of Chemistry, pp.188-232, 2022, Nanoscience & Nanotechnology Series, ⟨10.1039/9781839165498-00188⟩ |
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Chapter 4 : Membrane bioreactors for bio-artificial pancreasCurrent Trends and Future Developments on (Bio-) Membranes, Elsevier, pp.77-108, 2020, ⟨10.1016/b978-0-12-814225-7.00004-8⟩ |
Are Co-Culture Approaches Able to Improve Biological Functions of Bioartificial Livers?Biomedical Membranes and (Bio)Artificial Organs, 2, WORLD SCIENTIFIC, pp.179-210, 2018, 978-981-3223-97-4. ⟨10.1142/9789813223974_0007⟩ |
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Hemodynamics inside autologous arteriovenous fistulas.Medical Devices Design in Cardiovascular Applications., 2013 |
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Microencapsulation d'hépatocytes pour le développement d'un système de suppléance hépatique.Coord. Vandamme, Poncelet, Subra-Paternault. Microencapsulation : des sciences aux technologies, Lavoisier Editions Tec&Doc, pp.295-312, 2007 |
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Plasma Separation and Purification by MembraneEncyclopedia of Biomedical Engineering, Wiley-Interscience,, pp.2795-2804, 2006, 9780471740360. ⟨10.1002/9780471740360.ebs0935⟩ |
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Transcriptomic characterization of the synergy between human induced pluripotent stem cells-derived liver-and pancreas-on-chip coculture2025 |
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Spatial and mechanical environments regulate the heterogeneity of myonuclei2024 |