
CHRISTINE CITTI
- Interactions hôtes-agents pathogènes [Toulouse] (IHAP)
Présentation
My research interest focuses on combating and preventing animal infectious diseases including zoonoses. Early in my career, I studied how pathogenic bacteria (mycoplasmas) evade the host immune system by altering their surface composition and how they use cell-invasion to hide from the host immune response, survive, and disseminate. I further developed mycoplasma genetic tools and shifted my focus to functional genomics using new generation sequencing technologies. Using these tools, my group and I discovered a new mechanism of bacterial gene transfer which one plays a major role in their evolution, survival, and in accelerating the acquisition of antimicrobial resistance. My interest further shifted 10 years ago towards the ecological aspects of infectious diseases leading to my participation in the "Pathobiome" concept in 2014 (Vayssier-Taussat M, Albina E, Citti C et al. 2014 Shifting the paradigm from pathogens to pathobiome: new concepts in the light of meta-omics. Front Cell Infect Microbiol.) and in obtaining a 6-million-euro Horizon Europe project in 2022 to study the ecology of wildlife, livestock, human, and infectious diseases in changing environments (WiLiMan-ID). Finally, the COVID-19 pandemic highlighted the need for better preparedness and prevention of future pandemics. I was then appointed as the INRAE scientific focal point for the PREZODE initiative and co-pilot of the French PREZODE research program launched in January 2023. These initiatives aim to structure the scientific community to prevent zoonoses with pandemic potential, promote interdisciplinary global approaches, and involve decision-makers, citizens, and stakeholders to ensure their success.
At an early stage of career, I was appointed as the co-chair of the Institute of Bacteriology, Hygiene and Mycology, at the Veterinary University of Vienna, Austria (from 1997 to 2003). Since then and until today, I have been involved in the management of numerous collectives or collective programs of various sizes and at different scales (local, national or international) with the measured ambition of creating links and synergies between researchers, research teams and/or partners to address the growing complexity of the issues and the interdisciplinary or even transdisciplinary nature of the research questions we face.
Among these, my contribution as Deputy Director then Director of the research unit “Host-Pathogen Interactions” (IHAP, Toulouse, ca. 100 members, 6 research groups on infectious diseases) from 2006-2021 and as Scientific Director and member of the management team of the National Veterinary school of Toulouse from 2010 to 2015, were in my view the most sticking and instructive. These positions have enlarged my understanding and global vision of the research needs in terms of animal, human and environmental health.
Main research positions held.
Since 2023 Co-director of the “Programme et équipement Prioritaire de Recherche” (PEPR) Prezode (France 2030 and ANR).
Since 2022 Scientific focal point for INRAE for the International Initiative Prezode (Preventing zoonotic disease)
Since 2004 Research Director, UMR 1225 INRA-ENVT, Host-Pathogen Interaction, Veterinary National School of Toulouse and National Institute for Research in Agronomy, Toulouse, France
Since 2006 Group leader of the mycoplasma team, UMR 1225 INRA-ENVT Toulouse, France
1997-2004 Assistant Professor (until 2001) and Associate Professor (from 2001) in Molecular Microbiology, Research Group Leader, Institute of Bacteriology, Mycology and Hygiene, University of Veterinary Medicine Vienna, Austria
1993-1996 Postdoctoral Fellow, University of Missouri-Columbia, Columbia, MO, US
Main administrative and management positions held. 2015-2021 Chair of the joint research unit, UMR 1225 INRA-ENVT, Host-Pathogen Interactions, National Veterinary School of Toulouse, Toulouse, France 2010-2015 Dean for Research and Scientific affairs, Veterinary School of Toulouse, Toulouse, France. 2006-2015 Vice Chair of the joint research unit, UMR 1225 INRA-ENVT, Host-Pathogen Interactions, National Veterinary School of Toulouse, Toulouse, France 2000-2004 Deputy Chair, Institute of Bacteriology, Mycology and Hygiene, University of Veterinary Medicine Vienna, Austria
Publications
Publications
Relationship between microbiome and pathogens in the context of bovine respiratory complex: a longitudinal studyJournées d'animation scientifique du Département Santé Animale, Département SA INRAE, Sep 2024, Seignosse, France
Communication dans un congrès
hal-04709511
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Host Environmental Factors Promote Horizontal Dissemination of Integrative Conjugative Elements (ICE) in Ruminant Mycoplasmas25th Congres of the International Organization for Mycoplasmology, Jul 2024, Las Palmas De Gran Canaria, Spain
Communication dans un congrès
hal-04653941
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Role of the glycome-microbiome axis on susceptibility to bovine viral infections and on animal welfareSéminaire du métaprogramme SANBA, Oct 2024, Paris, France
Communication dans un congrès
hal-04888568
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The dynamism of calves’ respiratory and gut microbiome axis: stability, resilience, and individual patterns through health and diseaseJournées d'animation scientifique du Département Santé Animale, Département SA INRAE, Sep 2024, Seignosse, France
Communication dans un congrès
hal-04709490
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Airways and gut microbiome disturbance and resilience dynamics during polymicrobial bovine respiratory disease25th Congres of the International Organization for Mycoplasmology, Jul 2024, Las Palmas De Gran Canaria, Spain
Communication dans un congrès
hal-04654415
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Milk microbiota: potential allies for mammary gland healthADSA annual meeting 2023, American Dairy Science Association, Jun 2023, Ottawa, Canada. pp.146
Communication dans un congrès
hal-04164763
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The conjugative properties of Mycoplasma agalactiae are critically influenced by the expression of lipoprotein P48 at the surface of the recipient mating partner24th Congress of the International Organization for Mycoplasmology, Jul 2023, Osaka, Japan
Communication dans un congrès
hal-04343032
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Cartographie des régions chromosomiques participant au transfert d’ICE chez les mycoplasmes de ruminantsColloque International Francophone en Maladies Infectieuses Animales (CIFMIA 2022), May 2022, Montréal, Canada
Communication dans un congrès
hal-03770670
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ICE invasion into genome-reduced bacteria is driven by a lipoprotein exposed on the surface of the recipient cell23rd National Congress on Transposable Elements (CNET 2022), French research community working on transposable elements (CNET), Jul 2022, Gif-sur-Yvette, France
Communication dans un congrès
hal-03770684
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Mycoplasma conjugative chromosomal transfer: Influence of the antibiotic on the extent of genome mosaicismMICROBES 15ème congrès national de la SFM, Société française de la microbiologie (SFM), Sep 2019, Paris, France
Communication dans un congrès
hal-02933424
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In mycoplasma, horizontal chromosomal transfer could accelerate the emergence of antimicrobial resistance22th Congress of the International Organization for Mycoplasmology (IOM), IOM, Jul 2018, Portsmouth, New Hampshire, United States
Communication dans un congrès
hal-02933421
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The myth of codon optimisation: Higher exogenous protein expression in U. parvum, M. agalactiae, and M. capricolum when the lowest frequency codons were sporadically introduced22th Congress of the International Organization for Mycoplasmology (IOM 2018), IOM, Jul 2018, Portsmouth, United States
Communication dans un congrès
hal-02933420
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Horizontal distributive transfers and the extraordinary plasticity of the mycoplasma genome22th Congress of the International Organization for Mycoplasmology (IOM), IOM, Jul 2018, Portsmouth, New Hampshire, United States
Communication dans un congrès
hal-02933415
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Mutualisation de l’information génétique chez les mycoplasmes : une stratégie « open source » pour des génomes minimaux7ème Colloque international francophone de Microbiologie animale (CIFMA), Mar 2017, Liège, Belgique
Communication dans un congrès
hal-02933409
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Functional genomics of the Mycoplasma agalactiae Integrative Conjugative Element (ICEA)21th Congress of the International Organization for Mycoplasmology (IOM), Jul 2016, Brisbane, Australia
Communication dans un congrès
hal-02933406
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Large chromosomal replacements occur in vitro within and among ruminant mycoplasmas via an unconventional mechanism involving conjugation and homologous recombinationIOM 2014 - 20. Congress of the International Organization for Mycoplasmology, Jun 2014, Blumenau, Brazil
Communication dans un congrès
hal-02796081
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Wide dispersal and diversity of integrative conjugative elements within ruminant MycoplasmasIOM 2014 – 20th Congress of the International Organization for Mycoplasmology, Jun 2014, Blumenau, Brazil
Communication dans un congrès
hal-02796177
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Evolutionary history of contagious bovine pleuropneumonia using Next generation sequencing of <em>Mycoplasma mycoides</em> subsp.<em> mycoides</em> “small colonyIOM 2014 - 20. Congress of the International Organization for Mycoplasmology, Jun 2014, Blumenau, Brazil
Communication dans un congrès
hal-02797899
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Predicting the minimal translation apparatus: lessons from the reductive evolution of mollicutesIOM 2014 - 20. Congress of the International Organization for Mycoplasmology, Jun 2014, Blumenau, Brazil
Communication dans un congrès
hal-02797095
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Finishing bacterial genome assemblies with Mix11. Annual Research in Computational Molecular Biology (RECOMB) Satellite Workshop on Comparative Genomics, Institut National de Recherche en Informatique et en Automatique (INRIA). FRA., Oct 2013, Lyon, France. ⟨10.1186/1471-2105-14-S15-S16⟩
Communication dans un congrès
hal-02749841
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Genome-scale analysis of mycoplasma-host interactions: from cell culture to the natural host19th Congress of the International Organization for Mycoplasmology, Jul 2012, Toulouse, France
Communication dans un congrès
hal-02805801
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Changing paradigm on the evolution of Mycoplasmas by exploring their pan-genome.112th General meeting of American society for Microbiology (ASM), Jun 2012, San Franscisco, United States
Communication dans un congrès
hal-02933364
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Transposon-mediated gene-delivery to Ureaplasma parvum: development of a powerful tool for tracking infection and for functional genomic studies19th Congress of the International Organization for Mycoplasmology (IOM), Jul 2012, Toulouse, France
Communication dans un congrès
hal-02933401
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Plasmid Diversity in Ruminant Mycoplasmas19th Congress of the International Organization for Mycoplasmology (IOM), Jul 2012, Toulouse, France
Communication dans un congrès
hal-02933396
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The mycoplasma evolutive romance: a tale of DNA attraction19th Congress of the International Organization for Mycoplasmology (IOM), Jul 2012, Toulouse, France
Communication dans un congrès
hal-02933371
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A nano-love story for kilobase exchanges…Mycoplasma European Congress (Veterinary Laboratories Agency), Jun 2011, Weybridge, United Kingdom
Communication dans un congrès
hal-02933355
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Genome evolution and host specificity shape the surface proteome of mollicutesJournées des microbiologistes de l'INRA 2010, May 2010, Poitiers, France
Communication dans un congrès
hal-02753432
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Tetracycline-inducible gene expression in mollicutes18. Congress of the International Organization for Mycoplasmology, Jul 2010, Chianciano Terme, Italy
Communication dans un congrès
hal-02757746
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Shaping the surface proteome of minimal bacteria18. Congress of the International Organization for Mycoplasmology, Jul 2010, Chianciano Terme, Italy
Communication dans un congrès
hal-02756680
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Shaping the surface proteome of minimal bacteriaCongress of the International Organization for Mycoplasmology ; 2010/07/11-16 ; Chianciano Terme (ITA). IOM congress 2010, 2010, Chianciano Terme, Italy
Communication dans un congrès
hal-00648772
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Exploration fonctionnelle d'un génome minimal en systèmes cellulaires : application à Mycoplasma agalactiae, un pathogène des petits ruminantsJournées d’Animation Scientifique du Département Santé Animale, 2009, Port d'Albret, France. pp.Inconnu
Communication dans un congrès
hal-02814323
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Gene exchange among mycoplasmas: acquiring new potentials in a general context of massive gene loss4. European conference on prokaryotic genomics, Oct 2009, Göttingen, Germany
Communication dans un congrès
hal-02752687
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Prédire et identifier le protéome de surface de bactéries pathogènes minimalistes : une étape clé dans la compréhension des interactions hôtes-mollicutesAgroBI 2008, Dec 2008, Bordeaux, France
Communication dans un congrès
hal-02758038
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Small but dynamic genomes: evidences for massive horizontal gene transfer between ruminant pathogenic mycoplasmasGenomes 2008, Apr 2008, Paris, France
Communication dans un congrès
hal-02751198
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Gene exchange among mycoplasmas : acquiring new potentials in a general context of massive gene loss17. IOM Congress, Jul 2008, Tianjin, China
Communication dans un congrès
hal-02750849
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Comparing the genome and proteome of two Mycoplasma agalactiae strains : clues to the macro- and micro-events that are shaping mycoplasma diversity17. IOM Congress, Jul 2008, Tianjin, China
Communication dans un congrès
hal-02755919
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Anatomy of a hyper-variable genetic system in the Mycoplasma agalactiae species : extent, dynamics and evolution17. IOM Congress, Jul 2008, Tianjin, China
Communication dans un congrès
hal-02754102
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Plasticité génomique de Mycoplasma agalactiae : mécanismes et conséquences7e Rencontre Francophone de Mycoplasmologie, 2007, Lyon, France. pp.Inconnu
Communication dans un congrès
hal-02814854
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Mycoplasmas: from genomics to typingInternational Conference on Chlamydia and Mycoplasma Human Infections, 2007, Ferrara, Italy. pp.Inconnu
Communication dans un congrès
hal-02814249
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Horizontal gene transfer detection in mollicute bacteriaJournées Ouvertes Biologie, Informatique et Mathématiques (JOBIM),, 2007, Marseille, France. pp.Inconnu
Communication dans un congrès
hal-02813584
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Horizontal gene transfert detection in mollicutes bacteriaJOBIM 2007, Jul 2007, Marseille, France
Communication dans un congrès
hal-02750581
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Evolution des génomes de mollicutes : une histoire pleine de rebondissements7e Rencontre Francophone de Mycoplasmologie, 2007, Lyon, France. pp.Inconnu
Communication dans un congrès
hal-02813016
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Plasticité génomique de Mycoplasma agalactiae : mécanismes et conséquences7. Rencontre francophone de mycoplasmologie, Jul 2007, Lyon, France
Communication dans un congrès
hal-02757842
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Mycoplasmas: from genomics to typingInternational conference, Apr 2007, Ferrare, Italy
Communication dans un congrès
hal-02751928
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Leçon sur une question d'actualité par Mycoplasma agalactiae : comment gérer des ressources minimales tout en restant compétitif ?Journées d’Animation Scientifique du Département de Santé Animale, 2007, Tours, France. pp.Inconnu
Communication dans un congrès
hal-02814984
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Leçon sur une question d'actualité par Mycoplasma agalactiae : comment gérer des ressources minimales tout en restant compétitif ?Journées d'animation scientifique du Département Santé Animale, Jun 2007, Tours, France
Communication dans un congrès
hal-02756312
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Evolution des génomes de mollicutes : une histoire pleine de rebondissements7. Rencontre francophone de mycoplasmologie, Jul 2007, Lyon, France
Communication dans un congrès
hal-02755457
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Mycoplasma agalactiae genome: evidence for massive horizontal gene transfer between pathogenic, ruminant mycoplasmas16. International congress of the International Organization for Mycoplasmology, Jul 2006, Cambridge, United Kingdom
Communication dans un congrès
hal-02752179
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Colibacilles et mycoplasmes dans l'interaction hôte pathogène: du génome à la celluleJournées des Microbiologistes Toulousains «MicrobioToul 2005», 2005, Toulouse, France. pp.Inconnu
Communication dans un congrès
hal-02825580
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Role of Mycoplasma gallisepticum cythadherence proteins in colonization of experimentally infected chickens15th IOM Congress, 2004, Athens, United States
Communication dans un congrès
hal-02760275
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Suppression substractive hybridization for the identification of Mycoplasma agalactiae and Mycoplasma bovis species-specific DNA sequences15th IOM Congress, 2004, Athens, United States
Communication dans un congrès
hal-02760157
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Transposon mutagenesis of Mycoplasma gallisepticum : defining virulence genes15th IOM Congress, 2004, Athens, United States
Communication dans un congrès
hal-02763707
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Mycoplasma gallisepticum - Ein geeignetes Modell in der molekularen Pathogeneseforschung an Mykoplasmen,DVG-Tagung Fachgruppe, 2004, Berlin, Germany
Communication dans un congrès
hal-02759951
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In vivo and In vivo approaches to investigate Mycoplasma gallisepticum factors involved in colonization and systemic infection of chickens15th IOM Congress, 2004, Athens, United States
Communication dans un congrès
hal-02760387
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First steps towards the genetic manipulation of Mycoplasma agalactiae and Mycoplasma bovis using modified Tn4001 transposons15th IOM Congress, 2004, Athens, United States
Communication dans un congrès
hal-02758682
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Mycoplasma bovis : facteurs impliqués dans les interactions avec l'hôteJournées Européennes organisées par la Société Française de Buiatrie, 2004, Paris, France
Communication dans un congrès
hal-02760640
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Molekulare Grundlage der Pathogenität von Mycoplasma agalactiaeProceedings of the DVG-Tagung Fachgruppe, 2004, Berlin, Germany
Communication dans un congrès
hal-02760398
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UGA-UGG tryptophan tRNA genes in Spiroplasma citri8. International Congress, Jul 1990, Istanbul, Turkey
Communication dans un congrès
hal-02776273
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Genome of Spiroplasmas8. International Congress, Jul 1990, Istanbul, Turkey
Communication dans un congrès
hal-02774387
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Chromosomal DNA sequences coding for tRNAs recognizing UGA as a tryptophan codon in mollicutes7. Congress of the International Organization for Mycoplasmology, 1988, Baden, Austria
Communication dans un congrès
hal-02771978
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Molecular genetic tools for MollicutesMollicutes : Molecular Biology and Pathogenesis, Caister Academic Press, 2014, 978-1-908230-30-0
Chapitre d'ouvrage
hal-02800012
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Phenotypic diversity and cell invasion in host subversion by pathogenic mycoplasmasMycoplasma: Molecular biology, pathogenicity, and strategies for control, Horizon Bioscience, 2005, 0-8493-9861-4
Chapitre d'ouvrage
hal-02827621
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Bacterial Conjugation in the Ruminant Pathogen Mycoplasma agalactiae is Influenced by Eukaryotic Host Factors2025
Pré-publication, Document de travail
(preprint/prepublication)
hal-04954658
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Réflexion prospective interdisciplinaire Science pour les élevages de demain. Rapport de synthèse[0] INRAE. 2020, 53 pp
Rapport
hal-02899978
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Contribution a l'etude de l'organisation du genome de S. citri : caracterisation de deux tRNAsTRP chez S. citri et des genes correspondants. Organisation de genes de tRNAs et identification des genes pyrG, purA et purBSciences du Vivant [q-bio]. Université de Bordeaux Ségalen (Bordeaux 2), 1992. Français. ⟨NNT : ⟩
Thèse
tel-02843727
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Mécanismes d'adaptation des mycoplasmes de ruminants : comprendre les difficultés rencontrées dans le contrôle de l’infection par Mycoplasma bovisJournées nationales GTV 2023, 2023
Proceedings/Recueil des communications
hal-04703645
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