Christophe Klein

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Documents
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Publications

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Publications

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Neutralization of acyl coenzyme A binding protein for the experimental prevention and treatment of hepatocellular carcinoma

Sijing Li , Omar Motiño , Flavia Lambertucci , Jonathan Pol , Hui Chen et al.

Cell Reports Medicine, 2025, 6, ⟨10.1016/j.xcrm.2025.102232⟩

Article dans une revue hal-05210901v1

Laser-activated nanoparticles rewire tumor microenvironment enhancing PD-1 blockade and T cell response in cholangiocarcinoma

Mirko Minini , Giulio Avveduto , Sonia Becharef , Marie Meunier-Thaens , Bouchra Lekbaby et al. Article dans une revue hal-05411190v1

Spatial Profiling of Ovarian Carcinoma and Tumor Microenvironment Evolution under Neoadjuvant Chemotherapy

Elisa Yaniz-Galende , Qinghe Zeng , Juan Bejar-Grau , Christophe Klein , Felix Blanc-Durand et al.

Clinical Cancer Research, 2024, 30 (13), pp.2790-2800. ⟨10.1158/1078-0432.CCR-23-3836⟩

Article dans une revue hal-05029732v1
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Deep learning-based phenotyping reclassifies combined hepatocellular-cholangiocarcinoma

Julien Calderaro , Narmin Ghaffari Laleh , Qinghe Zeng , Pascale Maille , Loetitia Favre et al.

Nature Communications, 2023, 14 (1), pp.8290. ⟨10.1038/s41467-023-43749-3⟩

Article dans une revue hal-04439486v1

Artificial intelligence-based pathology as a biomarker of sensitivity to atezolizumab–bevacizumab in patients with hepatocellular carcinoma: a multicentre retrospective study

Qinghe Zeng , Christophe Klein , Stefano Caruso , Pascale Maille , Daniela Allende et al.

Lancet Oncology, 2023, 24 (12), pp.1411-1422. ⟨10.1016/S1470-2045(23)00468-0⟩

Article dans une revue hal-05391478v1
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A RAD51 functional assay as a candidate test for homologous recombination deficiency in ovarian cancer

Félix Blanc-Durand , Elisa Yaniz-Galende , Alba Llop-Guevara , Catherine Genestie , Violeta Serra et al.

Gynecologic Oncology, 2023, 171, pp.106-113. ⟨10.1016/j.ygyno.2023.01.026⟩

Article dans une revue hal-04210315v1
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Artificial intelligence predicts immune and inflammatory gene signatures directly from hepatocellular carcinoma histology

Qinghe Zeng , Christophe Klein , Stefano Caruso , Pascale Maille , Narmin Ghaffari Laleh et al.

Journal of Hepatology, 2022, 77 (1), pp.116-127. ⟨10.1016/j.jhep.2022.01.018⟩

Article dans une revue hal-04210277v1

Artificial intelligence for solid tumour diagnosis in digital pathology

Christophe Klein , Qinghe Zeng , Floriane Arbaretaz , Estelle Devêvre , Julien Calderaro et al.

British Journal of Pharmacology, 2021, 178 (21), pp.4291-4315. ⟨10.1111/bph.15633⟩

Article dans une revue hal-04210289v1
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Ileal immune tonus is a prognosis marker of proximal colon cancer in mice and patients

Marion Picard , Satoru Yonekura , Karolina Slowicka , Ioanna Petta , Conrad Rauber et al.

Cell Death and Differentiation, 2021, 28 (5), pp.1532-1547. ⟨10.1038/s41418-020-00684-w⟩

Article dans une revue hal-03682003v1
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Metabolic features of cancer cells impact immunosurveillance

Adrien Joseph , Pan Juncheng , Michele Mondini , Nizar Labaied , Mauro Loi et al.

Journal for Immunotherapy of Cancer, 2021, 9 (6), pp.e002362. ⟨10.1136/jitc-2021-002362⟩

Article dans une revue hal-03272265v1

Acidosis‐induced activation of distal nephron principal cells triggers Gdf15 secretion and adaptive proliferation of intercalated cells

Lydie Cheval , Benoit Viollet , Christophe Klein , Chloé Rafael , Lucile Figueres et al.

Acta Physiologica, 2021, pp.e13661. ⟨10.1111/apha.13661⟩

Article dans une revue hal-03208550v1
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Chemotherapy-induced ileal crypt apoptosis and the ileal microbiome shape immunosurveillance and prognosis of proximal colon cancer

Maria Paula Roberti , Satoru Yonekura , Connie P. M. Duong , Marion Picard , Gladys Ferrere et al.

Nature Medicine, 2020, 26 (6), p. 919-931. ⟨10.1038/s41591-020-0882-8⟩

Article dans une revue hal-03313676v1
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CFH exerts anti-oxidant effects on retinal pigment epithelial cells independently from protecting against membrane attack complex

Céline Borras , Jérémie Canonica , Sylvie Jorieux , Toufik Abache , Mohamed El Sanharawi et al.

Scientific Reports, 2019, 9 (1), ⟨10.1038/s41598-019-50420-9⟩

Article dans une revue hal-02345038v1
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Polyploidy spectrum: a new marker in HCC classification

Myriam Bou-Nader , Stefano Caruso , Romain Donne , Séverine Celton-Morizur , Julien Calderaro et al.

Gut, In press, pp.gutjnl-2018-318021. ⟨10.1136/gutjnl-2018-318021⟩

Article dans une revue hal-02102441v1

Sostdc1 is expressed in all major compartments of developing and adult mammalian eyes

Maud Valensi , Gabrielle Goldman , Dominique Marchant , Loïc van den Berghe , Laurent Jonet et al.

Graefe's Archive for Clinical and Experimental Ophthalmology, 2019, 257 (11), pp.2401-2427. ⟨10.1007/s00417-019-04462-4⟩

Article dans une revue hal-02461550v1

Metabolic enzymes expressed by cancer cells impact the immune infiltrate

Gautier Stoll , Margerie Kremer , Normal Bloy , Adrien Joseph , Maria Castedo et al.

OncoImmunology, 2019, 8 (6), pp.e1571389. ⟨10.1080/2162402X.2019.1571389⟩

Article dans une revue hal-02461563v1
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Active Fluctuations of the Nuclear Envelope Shape the Transcriptional Dynamics in Oocytes

Maria Almonacid , Adel Al Jord , Stephany El-Hayek , Alice Othmani , Fanny Coulpier et al.

Developmental Cell, 2019, 51 (2), pp.145-157.e10. ⟨10.1016/j.devcel.2019.09.010⟩

Article dans une revue hal-03003444v1
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Sustained Type I interferon signaling as a mechanism of resistance to PD-1 blockade

Nicolas Jacquelot , Takahiro Yamazaki , Maria Roberti , Connie Duong , Miles Andrews et al.

Cell Research, 2019, 29 (10), pp.846-861. ⟨10.1038/s41422-019-0224-x⟩

Article dans une revue hal-02461559v1

Gut microbiome influences efficacy of PD-1–based immunotherapy against epithelial tumors

Bertrand Routy , Emmanuelle Le Chatelier , Lisa Derosa , Connie Duong , Maryam Tidjani Alou et al.

Science, 2018, 359 (6371), pp.91-97. ⟨10.1126/science.aan3706⟩

Article dans une revue hal-02126484v1

Involvement of neural crest and paraxial mesoderm in oral mucosal development and healing

Juliane Isaac , Ali Nassif , Audrey Asselin , Ihsène Taïhi , Hélène Fohrer-Ting et al.

Biomaterials, 2018, 172, pp.41-53. ⟨10.1016/j.biomaterials.2018.04.036⟩

Article dans une revue hal-02461579v1

ROCK-1 mediates diabetes-induced retinal pigment epithelial and endothelial cell blebbing: Contribution to diabetic retinopathy

Pierre-Raphaël Rothschild , Sawsen Salah , Marianne Berdugo , Emmanuelle Gelize , Kimberley Delaunay et al.

Scientific Reports, 2017, 7 (1), ⟨10.1038/s41598-017-07329-y⟩

Article dans une revue hal-02461587v1

Contribution of RIP3 and MLKL to immunogenic cell death signaling in cancer chemotherapy

Heng Yang , Yuting Ma , Guo Chen , Heng Zhou , Takahiro Yamazaki et al.

OncoImmunology, 2016, 5 (6), pp.e1149673. ⟨10.1080/2162402X.2016.1149673⟩

Article dans une revue hal-02461588v1

Three-dimensional Organization of pKi-67: A Comparative Fluorescence and Electron Tomography Study Using Fluoronanogold

Thierry Cheutin , Marie-Françoise O'Donohue , Adrien Beorchia , Christophe Klein , Hervé H. Kaplan et al.

Journal of Histochemistry and Cytochemistry, 2016, 51 (11), pp.1411-1423. ⟨10.1177/002215540305101102⟩

Article dans une revue hal-02328305v1
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Targeting iron-mediated retinal degeneration by local delivery of transferrin

Émilie Picard , Quentin Le Rouzic , Antonin Oudar , Marianne Berdugo , Mohamed El Sanharawi et al.

Free Radical Biology and Medicine, 2015, 89, pp.1105-1121. ⟨10.1016/j.freeradbiomed.2015.08.018⟩

Article dans une revue inserm-02980617v1
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Anti-vascular endothelial growth factor acts on retinal microglia/macrophage activation in a rat model of ocular inflammation

Aude Couturier , Elodie Bousquet , Min Zhao , Marie-Christine Naud , Christophe Klein et al.

Molecular Vision, 2014, 20, pp.908-920

Article dans une revue hal-01332123v1

Protective effect of intravitreal injection of vasoactive intestinal peptide-loaded liposomes on experimental autoimmune uveoretinitis.

Emmanuelle Duron , Jean-Sébastien Vidal , Benoît Funalot , Cécile Viollet , Marie-Laure Seux et al.

Journals of Gerontology Series A: Biological Sciences and Medical Sciences, 2014, 69 (8), pp.1025-1032. ⟨10.1093/gerona/glt206⟩

Article dans une revue hal-02446108v1

DsRed-mediated oligomerization stabilizes HMGB1 on chromatin in vivo and on DNA in vitro

Melanie Messmer , Christophe Klein , Rachel Boniface , Nina F. Gnaedig , Maxime Lecerf et al.

Biochimie, 2013, 95 (4), pp.962-966. ⟨10.1016/j.biochi.2012.11.001⟩

Article dans une revue istex hal-01546170v1
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Live-cell imaging reveals multiple interactions between Epstein-Barr virus nuclear antigen 1 and cellular chromatin during interphase and mitosis.

Nathalie Jourdan , Aude Jobart-Malfait , Gabriel dos Reis , Frédérique Quignon , Tristan Piolot et al.

Journal of Virology, 2012, 86 (9), pp.5314-29. ⟨10.1128/JVI.06303-11⟩

Article dans une revue inserm-00679274v1
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Delta-like 4 inhibits choroidal neovascularization despite opposing effects on vascular endothelium and macrophages.

Serge Camelo , William Raoul , Sophie Lavalette , Bertrand Calippe , Brunella Cristofaro et al.

Angiogenesis, 2012, 15 (4), pp.609-22. ⟨10.1007/s10456-012-9290-0⟩

Article dans une revue inserm-00853034v1

Lipid droplet analysis in caveolin-deficient adipocytes: alterations in surface phospholipid composition and maturation defects

Cedric M Blouin , Soazig Le Lay , Anita Eberl , Harald Köfeler , Ida Chiara Guerrera et al.

Journal of Lipid Research, 2010, 51 (5), pp.945-956. ⟨10.1194/jlr.M001016⟩

Article dans une revue hal-02450951v1

Protective Effect of Intravitreal Injection of Vasoactive Intestinal Peptide–Loaded Liposomes on Experimental Autoimmune Uveoretinitis

Serge Camelo , Laure Lajavardi , Amélie Bochot , Brigitte Goldenberg , Marie-Christine Naud et al.

Journal of Ocular Pharmacology and Therapeutics, 2009, 25 (1), pp.9-22. ⟨10.1089/jop.2008.0074⟩

Article dans une revue hal-02507538v1

Insulin internalizes GLUT2 in the enterocytes of healthy but not insulin-resistant mice.

Vanessa Tobin , Maude Le Gall , Xavier Fioramonti , Emilie Stolarzcyk , Alba G Blazquez et al.

Diabetes, 2008, 57 (3), pp.555-62. ⟨10.2337/db07-0928⟩

Article dans une revue hal-00195152v1
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NKCC2 Surface Expression in Mammalian Cells

Boubacar Benziane , Sylvie Demaretz , Nadia Defontaine , Nancy Zaarour , Lydie L Cheval et al.

Journal of Biological Chemistry, 2007, 282 (46), pp.33817-33830. ⟨10.1074/jbc.M700195200⟩

Article dans une revue hal-03160997v1
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QN1/KIAA1009: a new essential protein for chromosome segregation and mitotic spindle assembly.

A. Leon , Boubaker Omri , A. Gely , Christophe Klein , Patricia Crisanti

Oncogene, 2006, 25 (13), pp.1887-95. ⟨10.1038/sj.onc.1209215⟩

Article dans une revue inserm-00146728v1

Nonrandom distribution of metaphase AgNOR staining patterns on human acrocentric chromosomes.

Laurent Héliot , Fabien Mongelard , Christophe Klein , Marie-Françoise O'Donohue , Jean-Marc Chassery et al.

Journal of Histochemistry and Cytochemistry, 2000, 48 (1), pp.13-20. ⟨10.1177/002215540004800102⟩

Article dans une revue hal-00192550v1

Nonrandom Distribution of Metaphase AgNOR Staining Patterns on Human Acrocentric Chromosomes

Laurent Héliot , Fabien Mongelard , Christophe Klein , Marie-Françoise O'Donohue , Jean-Marc Chassery et al.

Journal of Histochemistry and Cytochemistry, 2000, 48 (1), pp.13-20. ⟨10.1177/002215540004800102⟩

Article dans une revue hal-02328338v1
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Mounting Technique Allows Observation of Immuno-Labeled Cells on Plastic Coverslips

M.F. O'Donohue , T. Cheutin , C. Klein , H. Kaplan , D. Ploton

Biotechniques, 1998, 24 (6), pp.910-914. ⟨10.2144/98246bm01⟩

Article dans une revue hal-02328366v1

The Three-dimensional Study of Chromosomes and Upstream Binding Factor-immunolabeled Nucleolar Organizer Regions Demonstrates Their Nonrandom Spatial Arrangement during Mitosis

Christophe Klein , Thierry Cheutin , Lawrence Rothblum , Hervé H. Kaplan , Adrien Beorchia et al.

Molecular Biology of the Cell, 1998, 9 (11), pp.3147-3159. ⟨10.1091/mbc.9.11.3147⟩

Article dans une revue hal-02328359v1

Electron Tomography of Metaphase Nucleolar Organizer Regions: Evidence for a Twisted-Loop Organization

Laurent Héliot , Hervé H. Kaplan , Laurent Lucas , Christophe Klein , Adrien Beorchia et al.

Molecular Biology of the Cell, 1997, 8 (11), pp.2199-2216. ⟨10.1091/mbc.8.11.2199⟩

Article dans une revue hal-02328373v1
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A novel tool for detecting lysosomal membrane permeabilization by high-throughput fluorescence microscopy

Karla Alvarez-Valadez , Allan Sauvat , Hélène Fohrer-Ting , Christophe Klein , Oliver Kepp et al.

Monitoring Vesicular Trafficking in Cellular Responses to Stress - Part B, 165, Elsevier, pp.1-12, 2021, Methods in Cell Biology, ⟨10.1016/bs.mcb.2020.10.004⟩

Chapitre d'ouvrage inserm-03653036v1