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Christophe Klein

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A RAD51 functional assay as a candidate test for homologous recombination deficiency in ovarian cancer

Félix Blanc-Durand , Elisa Yaniz-Galende , Alba Llop-Guevara , Catherine Genestie , Violeta Serra
Gynecologic Oncology, 2023, 171, pp.106-113. ⟨10.1016/j.ygyno.2023.01.026⟩
Journal articles hal-04210315v1

New hormone receptor-positive breast cancer mouse cell line mimicking the immune microenvironment of anti-PD-1 resistant mammary carcinoma

Maria Perez-Lanzon , Vincent Carbonnier , Pierre Cordier , Fatima Domenica Elisa de Palma , Adriana Petrazzuolo
Journal for Immunotherapy of Cancer, 2023, 11 (6), pp.e007117. ⟨10.1136/jitc-2023-007117⟩
Journal articles hal-04210300v1

Deep learning-based phenotyping reclassifies combined hepatocellular-cholangiocarcinoma

Julien Calderaro , Narmin Ghaffari Laleh , Qinghe Zeng , Pascale Maille , Loetitia Favre
Nature Communications, 2023, 14 (1), pp.8290. ⟨10.1038/s41467-023-43749-3⟩
Journal articles hal-04439486v1

Periostin‐ and podoplanin‐positive cancer‐associated fibroblast subtypes cooperate to shape the inflamed tumor microenvironment in aggressive pancreatic adenocarcinoma

Cindy Neuzillet , Rémy Nicolle , Jérôme Raffenne , Annemilaï Tijeras-Raballand , Alexia Brunel
Journal of Pathology, 2022, 258 (4), pp.408-425. ⟨10.1002/path.6011⟩
Journal articles hal-04210308v1

Artificial intelligence predicts immune and inflammatory gene signatures directly from hepatocellular carcinoma histology

Qinghe Zeng , Christophe Klein , Stefano Caruso , Pascale Maille , Narmin Ghaffari Laleh
Journal of Hepatology, 2022, 77 (1), pp.116-127. ⟨10.1016/j.jhep.2022.01.018⟩
Journal articles hal-04210277v1

Artificial intelligence for solid tumour diagnosis in digital pathology

Christophe Klein , Qinghe Zeng , Floriane Arbaretaz , Estelle Devêvre , Julien Calderaro
British Journal of Pharmacology, 2021, 178 (21), pp.4291-4315. ⟨10.1111/bph.15633⟩
Journal articles hal-04210289v1
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Metabolic features of cancer cells impact immunosurveillance

Adrien Joseph , Pan Juncheng , Michele Mondini , Nizar Labaied , Mauro Loi
Journal for Immunotherapy of Cancer, 2021, 9 (6), pp.e002362. ⟨10.1136/jitc-2021-002362⟩
Journal articles hal-03272265v1
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Ileal immune tonus is a prognosis marker of proximal colon cancer in mice and patients

Marion Picard , Satoru Yonekura , Karolina Slowicka , Ioanna Petta , Conrad Rauber
Cell Death and Differentiation, 2021, 28 (5), pp.1532-1547. ⟨10.1038/s41418-020-00684-w⟩
Journal articles hal-03682003v1

Acidosis‐induced activation of distal nephron principal cells triggers Gdf15 secretion and adaptive proliferation of intercalated cells

Lydie Cheval , Benoit Viollet , Christophe Klein , Chloé Rafael , Lucile Figueres
Acta Physiologica, 2021, pp.e13661. ⟨10.1111/apha.13661⟩
Journal articles hal-03208550v1

Chemotherapy-induced ileal crypt apoptosis and the ileal microbiome shape immunosurveillance and prognosis of proximal colon cancer

Maria Paula Roberti , Satoru Yonekura , Connie Duong , Marion Picard , Gladys Ferrere
Nature Medicine, 2020, 26 (6), pp.919-931. ⟨10.1038/s41591-020-0882-8⟩
Journal articles hal-04210282v1
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Chemotherapy-induced ileal crypt apoptosis and the ileal microbiome shape immunosurveillance and prognosis of proximal colon cancer

Maria Paula Roberti , Satoru Yonekura , Connie P. M. Duong , Marion Picard , Gladys Ferrere
Nature Medicine, 2020, 26 (6), p. 919-931. ⟨10.1038/s41591-020-0882-8⟩
Journal articles hal-03313676v1
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Sustained Type I interferon signaling as a mechanism of resistance to PD-1 blockade

Nicolas Jacquelot , Takahiro Yamazaki , Maria Roberti , Connie Duong , Miles Andrews
Cell Research, 2019, 29 (10), pp.846-861. ⟨10.1038/s41422-019-0224-x⟩
Journal articles hal-02461559v1
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Active Fluctuations of the Nuclear Envelope Shape the Transcriptional Dynamics in Oocytes

Maria Almonacid , Adel Al Jord , Stephany El-Hayek , Alice Othmani , Fanny Coulpier
Developmental Cell, 2019, 51 (2), pp.145-157.e10. ⟨10.1016/j.devcel.2019.09.010⟩
Journal articles hal-03003444v1

Sostdc1 is expressed in all major compartments of developing and adult mammalian eyes

Maud Valensi , Gabrielle Goldman , Dominique Marchant , Loïc van den Berghe , Laurent Jonet
Graefe's Archive for Clinical and Experimental Ophthalmology, 2019, 257 (11), pp.2401-2427. ⟨10.1007/s00417-019-04462-4⟩
Journal articles hal-02461550v1
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CFH exerts anti-oxidant effects on retinal pigment epithelial cells independently from protecting against membrane attack complex

Céline Borras , Jérémie Canonica , Sylvie Jorieux , Toufik Abache , Mohamed El Sanharawi
Scientific Reports, 2019, 9 (1), ⟨10.1038/s41598-019-50420-9⟩
Journal articles hal-02345038v1
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Polyploidy spectrum: a new marker in HCC classification

Myriam Bou-Nader , Stefano Caruso , Romain Donne , Séverine Celton-Morizur , Julien Calderaro
Gut, inPress, pp.gutjnl-2018-318021. ⟨10.1136/gutjnl-2018-318021⟩
Journal articles hal-02102441v1

Metabolic enzymes expressed by cancer cells impact the immune infiltrate

Gautier Stoll , Margerie Kremer , Normal Bloy , Adrien Joseph , Maria Castedo
OncoImmunology, 2019, 8 (6), pp.e1571389. ⟨10.1080/2162402X.2019.1571389⟩
Journal articles hal-02461563v1

Gut microbiome influences efficacy of PD-1–based immunotherapy against epithelial tumors

Bertrand Routy , Emmanuelle Le Chatelier , Lisa Derosa , Connie Duong , Maryam Tidjani Alou
Science, 2018, 359 (6371), pp.91-97. ⟨10.1126/science.aan3706⟩
Journal articles hal-02126484v1

Involvement of neural crest and paraxial mesoderm in oral mucosal development and healing

Juliane Isaac , Ali Nassif , Audrey Asselin , Ihsène Taïhi , Hélène Fohrer-Ting
Biomaterials, 2018, 172, pp.41-53. ⟨10.1016/j.biomaterials.2018.04.036⟩
Journal articles hal-02461579v1

ROCK-1 mediates diabetes-induced retinal pigment epithelial and endothelial cell blebbing: Contribution to diabetic retinopathy

Pierre-Raphaël Rothschild , Sawsen Salah , Marianne Berdugo , Emmanuelle Gelize , Kimberley Delaunay
Scientific Reports, 2017, 7 (1), ⟨10.1038/s41598-017-07329-y⟩
Journal articles hal-02461587v1

Three-dimensional Organization of pKi-67: A Comparative Fluorescence and Electron Tomography Study Using Fluoronanogold

Thierry Cheutin , Marie-Françoise O'Donohue , Adrien Beorchia , Christophe Klein , Hervé H. Kaplan
Journal of Histochemistry and Cytochemistry, 2016, 51 (11), pp.1411-1423. ⟨10.1177/002215540305101102⟩
Journal articles hal-02328305v1

Contribution of RIP3 and MLKL to immunogenic cell death signaling in cancer chemotherapy

Heng Yang , Yuting Ma , Guo Chen , Heng Zhou , Takahiro Yamazaki
OncoImmunology, 2016, 5 (6), pp.e1149673. ⟨10.1080/2162402X.2016.1149673⟩
Journal articles hal-02461588v1
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Targeting iron-mediated retinal degeneration by local delivery of transferrin

Émilie Picard , Quentin Le Rouzic , Antonin Oudar , Marianne Berdugo , Mohamed El Sanharawi
Free Radical Biology and Medicine, 2015, 89, pp.1105-1121. ⟨10.1016/j.freeradbiomed.2015.08.018⟩
Journal articles inserm-02980617v1
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Anti-vascular endothelial growth factor acts on retinal microglia/macrophage activation in a rat model of ocular inflammation

Aude Couturier , Elodie Bousquet , Min Zhao , Marie-Christine Naud , Christophe Klein
Molecular Vision, 2014, 20, pp.908-920
Journal articles hal-01332123v1

Protective effect of intravitreal injection of vasoactive intestinal peptide-loaded liposomes on experimental autoimmune uveoretinitis.

Emmanuelle Duron , Jean-Sébastien Vidal , Benoît Funalot , Cécile Viollet , Marie-Laure Seux
Journals of Gerontology Series A: Biological Sciences and Medical Sciences, 2014, 69 (8), pp.1025-1032. ⟨10.1093/gerona/glt206⟩
Journal articles hal-02446108v1

DsRed-mediated oligomerization stabilizes HMGB1 on chromatin in vivo and on DNA in vitro

Melanie Messmer , Christophe Klein , Rachel Boniface , Nina F. Gnaedig , Maxime Lecerf
Biochimie, 2013, 95 (4), pp.962-966. ⟨10.1016/j.biochi.2012.11.001⟩
Journal articles hal-01546170v1
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Delta-like 4 inhibits choroidal neovascularization despite opposing effects on vascular endothelium and macrophages.

Serge Camelo , William Raoul , Sophie Lavalette , Bertrand Calippe , Brunella Cristofaro
Angiogenesis, 2012, 15 (4), pp.609-22. ⟨10.1007/s10456-012-9290-0⟩
Journal articles inserm-00853034v1
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Live-cell imaging reveals multiple interactions between Epstein-Barr virus nuclear antigen 1 and cellular chromatin during interphase and mitosis.

Nathalie Jourdan , Aude Jobart-Malfait , Gabriel dos Reis , Frédérique Quignon , Tristan Piolot
Journal of Virology, 2012, 86 (9), pp.5314-29. ⟨10.1128/JVI.06303-11⟩
Journal articles inserm-00679274v1

Lipid droplet analysis in caveolin-deficient adipocytes: alterations in surface phospholipid composition and maturation defects

Cedric M Blouin , Soazig Le Lay , Anita Eberl , Harald Köfeler , Ida Chiara Guerrera
Journal of Lipid Research, 2010, 51 (5), pp.945-956. ⟨10.1194/jlr.M001016⟩
Journal articles hal-02450951v1

Protective Effect of Intravitreal Injection of Vasoactive Intestinal Peptide–Loaded Liposomes on Experimental Autoimmune Uveoretinitis

Serge Camelo , Laure Lajavardi , Amélie Bochot , Brigitte Goldenberg , Marie-Christine Naud
Journal of Ocular Pharmacology and Therapeutics, 2009, 25 (1), pp.9-22. ⟨10.1089/jop.2008.0074⟩
Journal articles hal-02507538v1

Insulin internalizes GLUT2 in the enterocytes of healthy but not insulin-resistant mice.

Vanessa Tobin , Maude Le Gall , Xavier Fioramonti , Emilie Stolarzcyk , Alba G Blazquez
Diabetes, 2008, 57 (3), pp.555-62. ⟨10.2337/db07-0928⟩
Journal articles hal-00195152v1
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NKCC2 Surface Expression in Mammalian Cells

Boubacar Benziane , Sylvie Demaretz , Nadia Defontaine , Nancy Zaarour , Lydie L Cheval
Journal of Biological Chemistry, 2007, 282 (46), pp.33817-33830. ⟨10.1074/jbc.M700195200⟩
Journal articles hal-03160997v1
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QN1/KIAA1009: a new essential protein for chromosome segregation and mitotic spindle assembly.

A. Leon , Boubaker Omri , A. Gely , Christophe Klein , Patricia Crisanti
Oncogene, 2006, 25 (13), pp.1887-95. ⟨10.1038/sj.onc.1209215⟩
Journal articles inserm-00146728v1

Nonrandom Distribution of Metaphase AgNOR Staining Patterns on Human Acrocentric Chromosomes

Laurent Héliot , Fabien Mongelard , Christophe Klein , Marie-Françoise O'Donohue , Jean-Marc Chassery
Journal of Histochemistry and Cytochemistry, 2000, 48 (1), pp.13-20. ⟨10.1177/002215540004800102⟩
Journal articles hal-02328338v1

Nonrandom distribution of metaphase AgNOR staining patterns on human acrocentric chromosomes.

Laurent Héliot , Fabien Mongelard , Christophe Klein , Marie-Françoise O'Donohue , Jean-Marc Chassery
Journal of Histochemistry and Cytochemistry / Journal of Histochemistry & Cytochemistry, 2000, 48 (1), pp.13-20. ⟨10.1177/002215540004800102⟩
Journal articles hal-00192550v1

The Three-dimensional Study of Chromosomes and Upstream Binding Factor-immunolabeled Nucleolar Organizer Regions Demonstrates Their Nonrandom Spatial Arrangement during Mitosis

Christophe Klein , Thierry Cheutin , Lawrence Rothblum , Hervé H. Kaplan , Adrien Beorchia
Molecular Biology of the Cell, 1998, 9 (11), pp.3147-3159. ⟨10.1091/mbc.9.11.3147⟩
Journal articles hal-02328359v1
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Mounting Technique Allows Observation of Immuno-Labeled Cells on Plastic Coverslips

M.F. O'Donohue , T. Cheutin , C. Klein , H. Kaplan , D. Ploton
Biotechniques, 1998, 24 (6), pp.910-914. ⟨10.2144/98246bm01⟩
Journal articles hal-02328366v1

Electron Tomography of Metaphase Nucleolar Organizer Regions: Evidence for a Twisted-Loop Organization

Laurent Héliot , Hervé H. Kaplan , Laurent Lucas , Christophe Klein , Adrien Beorchia
Molecular Biology of the Cell, 1997, 8 (11), pp.2199-2216. ⟨10.1091/mbc.8.11.2199⟩
Journal articles hal-02328373v1