Claire Pecqueur

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Publications

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Inhibiting glioblastoma stem cells by targeting pyruvate carboxylase: A novel therapeutic strategy with both opportunities and challenges

Ophélie Renoult , Mélanie Laurent--Blond , Claire Pecqueur
Neuro-Oncology, 2025, 27 (2), pp.589 - 590. ⟨10.1093/neuonc/noae250⟩
Article dans une revue hal-04970019 v1
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Metabolic Profiling of Glioblastoma Stem Cells Reveals Pyruvate Carboxylase as a Critical Survival Factor and Potential Therapeutic Target

Ophélie Renoult , Mélanie Laurent--Blond , Hala Awada , Lisa Oliver , Noémie Joalland et al.
Neuro-Oncology, In press, Online ahead of print. ⟨10.1093/neuonc/noae106⟩
Article dans une revue (data paper) hal-04615662 v1
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Arming Vδ2 T cells with chimeric antigen receptors to combat cancer

Pauline Thomas , Pierre Paris , Claire Pecqueur
Clinical Cancer Research, In press, Online ahead of print. ⟨10.1158/1078-0432.CCR-23-3495⟩
Article dans une revue hal-04615675 v1
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CRCI 2 NA inaugural symposium: A meeting on tumor and immune ecosystems

Vincent J Guen , Gwennan André-Grégoire , Céline Beauvillain , Frank Boury , Morgane Chauvet et al.
Biology of the Cell, 2024, 116 (12), ⟨10.1111/boc.202400111⟩
Article dans une revue hal-04904114 v1
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Unraveling hallmark suitability for staging pre- and post-implantation stem cell models

Constance Onfray , Simon Chevolleau , Eva Moinard , Océane Girard , Kasturi Mahadik et al.
Cell Reports, 2024, 43 (5), pp.114232. ⟨10.1016/j.celrep.2024.114232⟩
Article dans une revue hal-04605043 v1
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The transcription factor ChREBP Orchestrates liver carcinogenesis by coordinating the PI3K/AKT signaling and cancer metabolism

Emmanuel Benichou , Bolaji Seffou , Selin Topçu , Ophélie Renoult , Véronique Lenoir et al.
Nature Communications, 2024, Nature Communications, 15 (1), pp.1879. ⟨10.1038/s41467-024-45548-w⟩
Article dans une revue hal-04696163 v1
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Osteoarthritic chondrocytes undergo a glycolysis-related metabolic switch upon exposure to IL-1b or TNF

Anais Defois , Nina Bon , Alexandre Charpentier , Mélina Georget , Nicolas Gaigeard et al.
Cell Communication and Signaling, 2023, 21 (1), pp.137. ⟨10.1186/s12964-023-01150-z⟩
Article dans une revue hal-04237446 v1
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Exploiting radiation immunostimulatory effects to improve glioblastoma outcome

Hala Awada , François Paris , Claire Pecqueur
Neuro-Oncology, 2023, 25 (3), pp.433-446. ⟨10.1093/neuonc/noac239⟩
Article dans une revue hal-04237361 v1
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The antitumor activity of human Vγ9Vδ2 T cells is impaired by TGF-β through significant phenotype, transcriptomic and metabolic changes

Chirine Rafia , Clément Loizeau , Ophélie Renoult , Christelle Harly , Claire Pecqueur et al.
Frontiers in Immunology, 2023, 13, pp.1066336. ⟨10.3389/fimmu.2022.1066336⟩
Article dans une revue inserm-04001857 v1
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The centrosomal protein 131 participates in the regulation of mitochondrial apoptosis

Clotilde Renaud , Kilian Trillet , Jane Jardine , Laura Merlet , Ophélie Renoult et al.
Communications Biology, 2023, 6 (1), pp.1271. ⟨10.1038/s42003-023-05676-3⟩
Article dans une revue hal-04391409 v1

UCP2 silencing restrains leukemia cell proliferation through glutamine metabolic remodeling

Tiphaine Sancerni , Ophélie Renoult , Angèle Luby , Cédric Caradeuc , Véronique Lenoir et al.
Frontiers in Immunology, 2022, 13, ⟨10.3389/fimmu.2022.960226⟩
Article dans une revue hal-03873718 v1

Expressing CD45RA (TEMRA) CD8+ T Cells from Kidney Transplant Recipients Exhibit Enhanced Purinergic P2X4 Receptor-Dependent Proinflammatory and Migratory Responses

Tra-My Doan Ngoc , Gaëlle Tilly , Richard Danger , Orianne Bonizec , Christophe Masset et al.
Journal of the American Society of Nephrology, 2022, 33 (12), pp.2211-2231. ⟨10.1681/ASN.2022030286⟩
Article dans une revue hal-03543095 v1
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Seipin localizes at endoplasmic-reticulum-mitochondria contact sites to control mitochondrial calcium import and metabolism in adipocytes

Yoann Combot , Veijo T. Salo , Gilliane Chadeuf , Maarit Hölttä , Katharina Ven et al.
Cell Reports, 2022, 38 (2), pp.110213. ⟨10.1016/j.celrep.2021.110213⟩
Article dans une revue hal-03534214 v1
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UCP2 silencing restrains leukemia cell proliferation through glutamine metabolic remodeling

Tiphaine Sancerni , Ophélie Renoult , Angèle Luby , Cédric Caradeuc , Véronique Lenoir et al.
Frontiers in Immunology, 2022, 13, pp.960226. ⟨10.3389/fimmu.2022.960226⟩
Article dans une revue hal-03817349 v1
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Wild-type isocitrate dehydrogenase under the spotlight in glioblastoma

Gabriel Alzial , Ophelie Renoult , François Paris , Catherine Gratas , Anne Clavreul et al.
Oncogene, 2021, Online ahead of print. ⟨10.1038/s41388-021-02056-1⟩
Article dans une revue inserm-03434277 v1
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Teriflunomide Treatment of Multiple Sclerosis Selectively Modulates CD8 Memory T Cells

Gaëlle Tilly , Marion Cadoux , Alexandra Garcia , Jérémy Morille , Sandrine Wiertlewski et al.
Frontiers in Immunology, 2021, 12, pp.730342. ⟨10.3389/fimmu.2021.730342⟩
Article dans une revue inserm-03366173 v1
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Glutamine uptake and utilization of human mesenchymal glioblastoma in orthotopic mouse model

Kristell Oizel , Chendong Yang , Ophelie Renoult , Fabien Gautier , Quyen N Do et al.
Cancer and Metabolism, 2020, 8, pp.9. ⟨10.1186/s40170-020-00215-8⟩
Article dans une revue inserm-03013555 v1
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Mitochondria transfer from tumor-activated stromal cells (TASC) to primary Glioblastoma cells

Céline Salaud , Arturo Alvarez-Arenas , Fanny Geraldo , Juan Belmonte-Beitia , Gabriel F Calvo et al.
Biochemical and Biophysical Research Communications, 2020, 533, pp.139 - 147. ⟨10.1016/j.bbrc.2020.08.101⟩
Article dans une revue inserm-03013565 v1
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Sphingolipids distribution at mitochondria-associated membranes (MAM) upon induction of apoptosis.

Vincent Mignard , Nolwenn Dubois , Didier Lanoé , Marie-Pierre M Joalland , Lisa Oliver et al.
Journal of Lipid Research, In press, pp.32350079. ⟨10.1194/jlr.RA120000628⟩
Article dans une revue inserm-02625440 v1
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Identification of a transient state during the acquisition of temozolomide resistance in glioblastoma

Marion Rabé , Solenne Dumont , Arturo Álvarez-Arenas , Hicham Janati , Juan Belmonte-Beitia et al.
Cell Death and Disease, 2020, 11 (1), ⟨10.1038/s41419-019-2200-2⟩
Article dans une revue hal-02429194 v1
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Impairing Temozolomide Resistance Driven by Glioma Stem-like Cells with adjuvant Immunotherapy Targeting O-acetyl GD2 Ganglioside

Julien Fleurence , Meriem Bahri , Sophie Fougeray , Sébastien Faraj , Sarah Vermeulen et al.
International Journal of Cancer, In press, Epub ahead of print. ⟨10.1002/ijc.32533⟩
Article dans une revue inserm-02168202 v1
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UCP2 Deficiency Increases Colon Tumorigenesis by Promoting Lipid Synthesis and Depleting NADPH for Antioxidant Defenses

Esther Aguilar , Pauline Esteves , Tiphaine Sancerni , Véronique Lenoir , Thomas Aparicio et al.
Cell Reports, 2019, 28 (9), pp.2306-2316.e5. ⟨10.1016/j.celrep.2019.07.097⟩
Article dans une revue inserm-02345411 v1
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Human Tolerogenic Dendritic Cells Regulate Immune Responses through Lactate Synthesis

Eros Marín , Laurence Bouchet-Delbos , Ophélie Renoult , Cédric Louvet , Véronique Nerriere-Daguin et al.
Cell Metabolism, 2019, 30 (6), pp.1075-1090. ⟨10.1016/j.cmet.2019.11.011⟩
Article dans une revue inserm-03013619 v1
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Glioblastoma Stem-Like Cells, Metabolic Strategy to Kill a Challenging Target

Delphine Garnier , Ophélie Renoult , Marie-Clotilde Alves-Guerra , François Paris , Claire Pecqueur
Frontiers in Oncology, 2019, 9, pp.118. ⟨10.3389/fonc.2019.00118⟩
Article dans une revue inserm-02240417 v1
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NKG2D controls natural reactivity of Vγ9Vδ2 T lymphocytes against mesenchymal glioblastoma cells

Cynthia Chauvin , Noémie Joalland , Jeanne Perroteau , Ulrich Jarry , Laura Lafrance et al.
Clinical Cancer Research, In press, clincanres.0375.2019 (Epub ahead of print). ⟨10.1158/1078-0432.CCR-19-0375⟩
Article dans une revue inserm-02316604 v1
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Stereotactic Adoptive Transfer of Cytotoxic Immune Cells in Murine Models of Orthotopic Human Glioblastoma Multiforme Xenografts

Ulrich Jarry , Noémie Joalland , Cynthia Chauvin , Beatrice Clemenceau , Claire Pecqueur et al.
Journal of visualized experiments : JoVE, 2018, 139, ⟨10.3791/57870⟩
Article dans une revue inserm-01885088 v1
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Parallel derivation of isogenic human primed and naive induced pluripotent stem cells

Stéphanie Kilens , Dimitri Meistermann , Diego Moreno , Caroline Chariau , Anne Gaignerie et al.
Nature Communications, 2018, 9 (1), pp.302 - 314. ⟨10.1038/s41467-017-02107-w⟩
Article dans une revue pasteur-01758726 v1
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IL-21 Increases the Reactivity of Allogeneic Human Vγ9Vδ2 T Cells Against Primary Glioblastoma Tumors

Noémie Joalland , Cynthia Chauvin , Lisa Oliver , François M. Vallette , Claire Pecqueur et al.
Journal of immunotherapy : official journal of the Society for Biological Therapy, 2018, 41 (5), pp.224-231. ⟨10.1097/CJI.0000000000000225⟩
Article dans une revue inserm-01804994 v1
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Ionizing radiation induces long-term senescence in endothelial cells through mitochondrial respiratory complex II dysfunction and superoxide generation

Audrey Lafargue , Charlotte Degorre , Isabelle Corre , Marie-Clotilde Alves-Guerra , Marie-Hélène Gaugler et al.
Free Radical Biology and Medicine, 2017, 108, pp.750-759. ⟨10.1016/j.freeradbiomed.2017.04.019⟩
Article dans une revue inserm-01514403 v1
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Efficient Mitochondrial Glutamine Targeting Prevails Over Glioblastoma Metabolic Plasticity

Kristell Oizel , Cynthia Chauvin , Lisa Oliver , Catherine Gratas , Fanny Geraldo et al.
Clinical Cancer Research, 2017, 23 (20), ⟨10.1158/1078-0432.CCR-16-3102⟩
Article dans une revue inserm-01595798 v1
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IL-15 Harnesses Pro-inflammatory Function of TEMRA CD8 in Kidney-Transplant Recipients

Gaëlle Tilly , Tra-My Doan-Ngoc , Michelle Yap , Aurélie Caristan , Lola Jacquemont et al.
Frontiers in Immunology, 2017, 8, pp.778. ⟨10.3389/fimmu.2017.00778⟩
Article dans une revue inserm-01819099 v1
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Seipin deficiency alters brown adipose tissue thermogenesis and insulin sensitivity in a non-cell autonomous mode

Thierry Le Tourneau , J. Magré , M. Joubert , C Le May , Audrey Ayer et al.
Scientific Reports, 2016, 6, pp.35487 - 35487. ⟨10.1038/srep35487⟩
Article dans une revue inserm-01414140 v1
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Low-Dose Pesticide Mixture Induces Senescence In Normal Mesenchymal Stem Cells (MSC) And Promotes Tumorigenic PhenotypeIn Premalignant MSC

Mazène Hochane , Valérie Trichet , Claire Pecqueur , Pierre Avril , Lisa Oliver et al.
STEM CELLS, 2016, ⟨10.1002/stem.2539⟩
Article dans une revue inserm-01398601 v1
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Stereotaxic administrations of allogeneic human Vγ9Vδ2 T cells efficiently control the development of human glioblastoma brain tumors

Ulrich Jarry , Cynthia Chauvin , Noémie Joalland , Alexandra Léger , Sandrine Minault et al.
OncoImmunology, 2016, 5 (6), pp.e1168554. ⟨10.1080/2162402X.2016.1168554⟩
Article dans une revue inserm-01342603 v1
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D-2-Hydroxyglutarate does not mimic all the IDH mutation effects, in particular the reduced etoposide-triggered apoptosis mediated by an alteration in mitochondrial NADH

K Oizel , C Gratas , Adulraj Nadaradjane , Lisa Oliver , F Vallette et al.
Cell Death and Disease, 2015, 6 (3), ⟨10.1038/cddis.2015.13⟩
Article dans une revue inserm-01818661 v1
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Targeting CD8 T-Cell Metabolism in Transplantation

Michelle Yap , Sophie Brouard , Claire Pecqueur , Nicolas Degauque
Frontiers in Immunology, 2015, 6, pp.547. ⟨10.3389/fimmu.2015.00547⟩
Article dans une revue inserm-02147167 v1
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Radiation-induced PGE 2 sustains human glioma cell growth and survival through EGF signaling

Emeline Brocard , Kristell Oizel , Lisenn Lalier , Claire Pecqueur , François Paris et al.
Oncotarget, 2015, 6 (9), pp.6840-6849. ⟨10.18632/oncotarget.3160⟩
Article dans une revue inserm-02914000 v1
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Control of glioma cell death and differentiation by PKM2–Oct4 interaction

M Morfouace , Lisenn Lalier , L Oliver , M Cheray , Claire Pecqueur et al.
Cell Death and Disease, 2014, 5, pp.e1036. ⟨10.1038/cddis.2013.561⟩
Article dans une revue inserm-03369748 v1
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UCP2 induces metabolic reprogramming to inhibit proliferation of cancer cells

Esteves Pauline , Claire Pecqueur , Alves-Guerra Marie-Clotilde
Molecular & Cellular Oncology, 2014, 2 (1), ⟨10.4161/23723556.2014.975024⟩
Article dans une revue inserm-01207304 v1
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Targeting Metabolism to Induce Cell Death in Cancer Cells and Cancer Stem Cells

Claire Pecqueur , Lisa Oliver , Kristell Oizel , Lisenn Lalier , François M Vallette
International Journal of Biochemistry and Cell Biology, 2013, 2013, pp.805975. ⟨10.1155/2013/805975⟩
Article dans une revue inserm-02447021 v1

Differentiation-Related Response to DNA Breaks in Human Mesenchymal Stem Cells

Lisa Oliver , Erika Hue , Quentin Séry , Audrey Lafargue , Claire Pecqueur et al.
STEM CELLS, 2013, 31 (4), pp.800-807. ⟨10.1002/stem.1336⟩
Article dans une revue hal-01968395 v1
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Analysis of Uncoupling Protein 2-Deficient Mice upon Anaesthesia and Sedation Revealed a Role for UCP2 in Locomotion

Marie-Clotilde Alves-Guerra , Caroline Aheng , Claire Pecqueur , Sandrine Masscheleyn , Pierre Louis Tharaux et al.
PLoS ONE, 2012, 7 (8), pp.e41846. ⟨10.1371/journal.pone.0041846⟩
Article dans une revue hal-02347202 v1

UCP2, a metabolic sensor coupling glucose oxidation to mitochondrial metabolism?

Claire Pecqueur , Clotilde Alves-Guerra , Daniel Ricquier , Frédéric Bouillaud
IUBMB Life, 2009, 61 (7), pp.762-767. ⟨10.1002/iub.188⟩
Article dans une revue hal-02347239 v1

UCP2, a metabolic sensor coupling glucose oxidation to mitochondrial metabolism?

Claire Pecqueur , Clotilde Alves-Guerra , Daniel Ricquier , Frederic Bouillaud
IUBMB Life, 2009, 61 (7), pp.762-767. ⟨10.1002/iub.188⟩
Article dans une revue hal-03055035 v1
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Uncoupling protein-2 controls proliferation by promoting fatty acid oxidation and limiting glycolysis-derived pyruvate utilization

Claire Pecqueur , Thi Bui , Chantal Gelly , Julie Hauchard , Céline Barbot et al.
FASEB Journal, 2008, 22 (1), pp.9-18. ⟨10.1096/fj.07-8945com⟩
Article dans une revue inserm-02446962 v1

Expression of UCP3 in CHO cells does not cause uncoupling, but controls mitochondrial activity in the presence of glucose.

Julien Mozo , Gilles Ferry , Aurélie Studeny , Claire Pecqueur , Marianne Rodriguez et al.
Biochemical Journal, 2006, 393 (Pt 1), pp.431-9. ⟨10.1042/BJ20050494⟩
Article dans une revue hal-00136148 v1

Tissue-specific effects of leptin administration on the abundance of mitochondrial proteins during neonatal development

M Gnanalingham , A Mostyn , J Wang , R Webb , D Keisler et al.
Journal of Endocrinology, 2005, 187 (1), pp.81-88. ⟨10.1677/joe.1.06251⟩
Article dans une revue hal-03055003 v1

Influence of genotype on the differential ontogeny of uncoupling protein 2 and 3 in subcutaneous adipose tissue and muscle in neonatal pigs

A Mostyn , J Litten , K Perkins , M Alves-Guerra , Claire Pecqueur et al.
Journal of Endocrinology, 2004, 183 (1), pp.121-131. ⟨10.1677/joe.1.05448⟩
Article dans une revue hal-03054882 v1

Bone Marrow Transplantation Reveals the in Vivo Expression of the Mitochondrial Uncoupling Protein 2 in Immune and Nonimmune Cells during Inflammation

Marie-Clotilde Alves-Guerra , Sophie Rousset , Claire Pecqueur , Ziad Mallat , Julie Blanc et al.
Journal of Biological Chemistry, 2003, 278 (43), pp.42307-42312. ⟨10.1074/jbc.M306951200⟩
Article dans une revue hal-03054592 v1

Bone Marrow Transplantation Reveals the in Vivo Expression of the Mitochondrial Uncoupling Protein 2 in Immune and Nonimmune Cells during Inflammation

Marie-Clotilde Alves-Guerra , Sophie Rousset , Claire Pecqueur , Ziad Mallat , Julie Blanc et al.
Journal of Biological Chemistry, 2003, 278 (43), pp.42307-42312. ⟨10.1074/jbc.M306951200⟩
Article dans une revue hal-04719655 v1

Uncoupling Protein 2, in Vivo Distribution, Induction upon Oxidative Stress, and Evidence for Translational Regulation

Claire Pecqueur , Marie-Clotilde Alves-Guerra , Chantal Gelly , Corinne Lévi-Meyrueis , Elodie Couplan et al.
Journal of Biological Chemistry, 2001, 276 (12), pp.8705-8712. ⟨10.1074/jbc.M006938200⟩
Article dans une revue hal-03054560 v1

Transcriptional Activation of the Human ucp1 Gene in a Rodent Cell Line

Maria del Mar Gonzalez-Barroso , Claire Pecqueur , Chantal Gelly , Daniel Sanchis , Marie-Clotilde Alves-Guerra et al.
Journal of Biological Chemistry, 2000, 275 (41), pp.31722-31732. ⟨10.1074/jbc.M001678200⟩
Article dans une revue hal-04719654 v1

Transcriptional Activation of the Human ucp1 Gene in a Rodent Cell Line

Maria del Mar Gonzalez-Barroso , Claire Pecqueur , Chantal Gelly , Daniel Sanchis , Marie-Clotilde Alves-Guerra et al.
Journal of Biological Chemistry, 2000, 275 (41), pp.31722-31732. ⟨10.1074/jbc.M001678200⟩
Article dans une revue hal-03054399 v1

Disruption of the uncoupling protein-2 gene in mice reveals a role in immunity and reactive oxygen species production

Denis Arsenijevic , Hiroki Onuma , Claire Pecqueur , Serge Raimbault , Brian Manning et al.
Nature Genetics, 2000, 26 (4), pp.435-439. ⟨10.1038/82565⟩
Article dans une revue hal-03054550 v1