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Dimitri Kereselidze

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Présentation

Grâce à mes 14 ans d’expérience professionnelle, j’ai développé de multiples compétences pour exercer avec rigueur et méthodes mon métier de technicien supérieur de recherche. Force de proposition et agile dans la gestion des projets, je m’implique naturellement au sein des équipes et participe activement aux projets.


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Publications

Preclinical evaluation of theranostic strategy using nanoplatform and transferrin to target hyperactivity of cMYC in the context of non-small cell lung cancer

S. Martin-Aubert , M. Richard , Dimitri Kereselidze , C. Comtat , C. Denis et al.
Journal de Biophysique et Medecine Nucleaire, 2025, 49 (1), pp.25. ⟨10.1016/j.mednuc.2024.12.056⟩
Article dans une revue hal-05032439 v1

PET Imaging of PD-L1 Occupancy for Preclinical Assessment of the Efficacy of Combined Anti–PD-L1 Immunotherapy and Targeted Therapy

Céline Chevaleyre , Lea Zimmermann , Simon Specklin , Dimitri Kereselidze , Alizée Bouleau et al.
Journal of Nuclear Medicine, 2025, 66 (4), pp.559-564. ⟨10.2967/jnumed.124.268586⟩
Article dans une revue hal-05032430 v1

Successful repositioning of mertansine for improved chemotherapy by combining a polymer prodrug approach and PET imaging

Soizic Martin-Aubert , Kevin Avrillon , Nicolas Tournier , Alexandre Bordat , Vu Long Tran et al.
Journal of Controlled Release, 2025, 378, pp.803-813. ⟨10.1016/j.jconrel.2024.12.050⟩
Article dans une revue hal-04927661 v1
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Low to moderate dose 137 Cs (γ) radiation promotes M2 type macrophage skewing and reduces atherosclerotic plaque CD68+ cell content in ApoE (-/-) mice

Nicolas Rey , Celine Gloaguen , Dimitri Kereselidze , Christelle Elie , Chloe Brizais et al.
Scientific Reports, 2024, 14 (1), pp.12450. ⟨10.1038/s41598-024-63084-x⟩
Article dans une revue irsn-04595016 v1

Radiothérapie interne vectorisée au 18F-PSMA-1007 dans le cancer de la prostate améliorée par sono-perméabilisation dans un modèle préclinique murin

S. Tran , Dimitri Kereselidze , L. Jourdain , J.M. Daugas , A. Novell et al.
Journal de Biophysique et Medecine Nucleaire, 2024, 48 (2), pp.48-49. ⟨10.1016/j.mednuc.2024.01.009⟩
Article dans une revue hal-05032445 v1

Imagerie prédictive de la réponse à l’immunothérapie par immunoPET via une nouvelle cible (CD103) et des formats protéiques innovants

L. Zimmermann , C. Chevaleyre , Dimitri Kereselidze , S.S. Dubois , C. Tanchot et al.
Journal de Biophysique et Medecine Nucleaire, 2024, 48 (2), pp.68. ⟨10.1016/j.mednuc.2024.01.043⟩
Article dans une revue hal-05032447 v1
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A cancer immunoprofiling strategy using mass spectrometry coupled with bioorthogonal cleavage

Maxime Ribéraud , Estelle Porret , Alain Pruvost , Frédéric Theodoro , Anvi Laëtitia Nguyen et al.
Chemical Science, 2024, 15 (45), pp.18825-18831. ⟨10.1039/d4sc04471a⟩
Article dans une revue hal-05032431 v1
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Preoperative PET imaging and fluorescence-guided surgery of human glioblastoma using dual-labeled antibody targeting ET<sub>A</sub> receptors in a preclinical mouse model: A theranostic approach

Marie Hautiere , Delphine Vivier , Paul Dorval , Donovan Pineau , Dimitri Kereselidze et al.
Theranostics, 2024, 14 (16), pp.6268-6280. ⟨10.7150/thno.98163⟩
Article dans une revue hal-05032432 v1

Développement d’un nouvel outil d’imagerie ciblant un nouveau biomarqueur en oncologie : le récepteur à la vasopressine de type 2 (V2R)

Goran Stanajic-Petrovic , Dimitri Kereselidze , B. Jego , C. Denis , P. Kessler et al.
Journal de Biophysique et Medecine Nucleaire, 2023, 47 (2), pp.51. ⟨10.1016/j.mednuc.2023.01.024⟩
Article dans une revue hal-05032441 v1
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Refining the delivery and therapeutic efficacy of cetuximab using focused ultrasound in a mouse model of glioblastoma: An 89Zr-cetuximab immunoPET study

Estelle Porret , Dimitri Kereselidze , Ambre Dauba , Arnaud Schweitzer-Chaput , Benoit Jegot et al.
European Journal of Pharmaceutics and Biopharmaceutics, 2023, 182, pp.141-151. ⟨10.1016/j.ejpb.2022.12.006⟩
Article dans une revue hal-04254579 v1
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Local and distant response to intratumoral immunotherapy assessed by immunoPET in mice

Louis Meyblum , Céline Chevaleyre , Sandrine Susini , Benoit Jego , Frederic Deschamps et al.
Journal for Immunotherapy of Cancer, 2023, 11 (11), pp.e007433. ⟨10.1136/jitc-2023-007433⟩
Article dans une revue hal-05032434 v1
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Efficient PD-L1 imaging of murine glioblastoma with FUS-aided immunoPET by leveraging FcRn-antibody interaction

Céline Chevaleyre , Anthony Novell , Nicolas Tournier , Ambre Dauba , Steven Dubois et al.
Theranostics, 2023, 13 (15), pp.5584-5596. ⟨10.7150/thno.87168⟩
Article dans une revue hal-04469846 v1

ImmunoPET imaging–based pharmacokinetic profiles of an antibody and its Fab targeting endothelin A receptors on glioblastoma stem cells in a preclinical orthotopic model

Marie Hautiere , Delphine Vivier , Donovan Pineau , Caroline Denis , Dimitri Kereselidze et al.
European Journal of Nuclear Medicine and Molecular Imaging, 2023, 50 (11), pp.3192-3201. ⟨10.1007/s00259-023-06268-3⟩
Article dans une revue hal-04122041 v1

Pharmacokinetics derived from PET imaging of inspiring radio-enhancer platinum nanoparticles

Xiaomin Yang , Vu Long Tran , Hynd Remita , Farah Savina , Caroline Denis et al.
Nanomedicine: Nanotechnology, Biology and Medicine, 2022, 46 (5), pp.102603. ⟨10.1016/j.nano.2022.102603⟩
Article dans une revue hal-03862108 v1
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Multigenerational Exposure to Uranium Changes Sperm Metabolome in Rats

Stéphane Grison , Audrey Legendre , Ljubica Svilar , Christelle Elie , Dimitri Kereselidze et al.
International Journal of Molecular Sciences, 2022, 23 (15), pp.8349. ⟨10.3390/ijms23158349⟩
Article dans une revue hal-03791887 v1
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Early metabolomics markers of an acute low-dose exposure to uranium in rats

Stephane Grison , Baninia Habchi , Celine Gloaguen , Dimitri Kerezelidze , Christelle Elie et al.
Metabolites, 2022, 12 (5), pp.421. ⟨10.3390/metabo12050421⟩
Article dans une revue hal-03726800 v1

Impact of Radiolabeling Strategies on the Pharmacokinetics and Distribution of an Anti-PD-L1 PET Ligand

Vu Long Tran , Alizée Bouleau , Hervé Nozach , Mylène Richard , Céline Chevaleyre et al.
Molecular Pharmaceutics, 2022, 19 (10), pp.3673-3680. ⟨10.1021/acs.molpharmaceut.2c00497⟩
Article dans une revue hal-05032436 v1

Pharmacokinetics derived from PET imaging of inspiring radio-enhancer platinum nanoparticles

Xiaomin Yang , Vu Long Tran , Hynd Remita , Farah Savina , Caroline Denis et al.
Nanomedicine: Nanotechnology, Biology and Medicine, 2022, 46, pp.102603. ⟨10.1016/j.nano.2022.102603⟩
Article dans une revue hal-04294244 v1

Optimizing Immuno-PET Imaging of Tumor PD-L1 Expression: Pharmacokinetic, Biodistribution, and Dosimetric Comparisons of 89 Zr-Labeled Anti-PD-L1 Antibody Formats

Alizée Bouleau , Hervé Nozach , Steven Dubois , Dimitri Kereselidze , Céline Chevaleyre et al.
Journal of Nuclear Medicine, 2022, 63 (8), pp.1259-1265. ⟨10.2967/jnumed.121.262967⟩
Article dans une revue hal-04480942 v1
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TSPO PET Imaging as a Potent Non-Invasive Biomarker for Diffuse Intrinsic Pontine Glioma in a Patient-Derived Orthotopic Rat Model

Céline Chevaleyre , Dimitri Kereselidze , Fabien Caillé , Nicolas Tournier , Nagore G Olaciregui et al.
International Journal of Molecular Sciences, 2022, 23 (20), pp.12476. ⟨10.3390/ijms232012476⟩
Article dans une revue hal-05032435 v1
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Targeted Dorsal Dentate Gyrus or Whole Brain Irradiation in Juvenile Mice Differently Affects Spatial Memory and Adult Hippocampal Neurogenesis

Céline Serrano , Morgane Dos Santos , Dimitri Kereselidze , Louison Beugnies , Philippe Lestaevel et al.
Biology, 2021, 10 (3), pp.192. ⟨10.3390/biology10030192⟩
Article dans une revue irsn-04337723 v1
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Renal adaptive response to exposure to low doses of uranyl nitrate and sodium fluoride in mice

Alice Bontemps , Victor Magneron , Laurine Conquet , Christelle Elie , Celine Gloaguen et al.
Journal of Trace Elements in Medicine and Biology, 2021, 64, pp.126708. ⟨10.1016/j.jtemb.2020.126708⟩
Article dans une revue hal-03471501 v1
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Exposure to low to moderate doses of ionizing radiation induces a reduction of pro-inflammatory Ly6Chigh monocytes and a U-curved response of T cells in ApoE -/- mice

Nicolas Rey , Talin Ebrahimian , Celine Gloaguen , Dimitri Kerezelidze , Victor Magneron et al.
Dose-Response, 2021, 19 (2), pp.1-9. ⟨10.1177/15593258211016237⟩
Article dans une revue hal-03608570 v1
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Effect of repetitive potassium iodide on thyroid and cardiovascular functions in elderly rats

Dalila Lebsir , Elsa Cantabella , David Cohen , Amandine Sache , Teni Ebrahimian Chiusa et al.
Biochemistry and Biophysics Reports, 2020, 24, pp.100816. ⟨10.1016/j.bbrep.2020.100816⟩
Article dans une revue hal-03070577 v1
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Optimization of Dosimetry in Alpha Therapy : Microlocalisation of 223Ra in Mouse Models of Metastasis from Prostate Cancer and Renal Cell Carcinoma

Nadia Benabdallah , Catherine Saï-Maurel , Didier Franck , Claire de Labriolle-Vaylet , Aurélie Desbrée et al.
Journal of Medical Imaging and Radiation Sciences, 2019, 50, pp.S10
Article dans une revue inserm-02340727 v1
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In vivo comparison of the phenotypic aspects and molecular mechanisms of two nephrotoxic agents, sodium fluoride and uranyl nitrate

A. Bontemps , L. Conquet , C. Elie , V. Magneron , C. Gloaguen et al.
International Journal of Environmental Research and Public Health, 2019, 16 (7), pp.1136. ⟨10.3390/ijerph16071136⟩
Article dans une revue hal-02524211 v1
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Multigenerational exposure to uranium changes morphometric parameters and global DNA methylation in rat sperm

Audrey Legendre , Ghada Elhmiri , Celine Gloaguen , Victor Magneron , Dimitri Kereselidze et al.
Comptes Rendus. Biologies, 2019, 342 (5-6), pp.175-185. ⟨10.1016/j.crvi.2019.07.002⟩
Article dans une revue hal-02444480 v1
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Applying a multiscale systems biology approach to study the effect of chronic low-dose exposure to uranium in rat kidneys

Stephane Grison , Dimitri Kereselidze , David Cohen , Celine Gloaguen , Christelle Elie et al.
International Journal of Radiation Biology, 2019, 95 (6), pp.737-752. ⟨10.1080/09553002.2019.1577567⟩
Article dans une revue hal-02457223 v1
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Repeated potassium iodide exposure during pregnancy impairs progeny’s brain development

D. Lebsir , J. Guemri , D. Kereselidze , S. Grison , M. Benderitter et al.
Neuroscience, 2019, 406, pp.606-616. ⟨10.1016/j.neuroscience.2019.02.016⟩
Article dans une revue hal-02524208 v1
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Hto, Tritiated Amino Acid Exposure and External Exposure Induce Differential Effects on Hematopoiesis and Iron Metabolism

Jean Marc Bertho , Dimitri Kereselidze , Line Manens , Cécile Culeux , Victor Magneron et al.
Scientific Reports, 2019, 9 (1), pp.19919. ⟨10.1038/s41598-019-56453-4⟩
Article dans une revue hal-02444481 v1
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DNA methylation and potential multigenerational epigenetic effects linked to uranium chronic low-dose exposure in gonads of males and females rats

Ghada Elmhiri , Celine Gloaguen , Stephane Grison , Dimitri Kereselidze , Christelle Elie et al.
Toxicology Letters, 2018, 282, pp.64-70. ⟨10.1016/j.toxlet.2017.10.004⟩
Article dans une revue hal-02635731 v1
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Development of whole brain versus targeted dentate gyrus irradiation model to explain low to moderate doses of exposure effects in mice

Morgane dos Santos , Dimitri Kereselidze , Celine Gloaguen , Mohamedamine Benadjaoud , Karine Tack et al.
Scientific Reports, 2018, 8 (1), pp.17262. ⟨10.1038/s41598-018-35579-x⟩
Article dans une revue hal-02443070 v1

Low dose of uranium induces multigenerational epigenetic effects in rat kidney

S. Grison , G. Elmhiri , C. Gloaguen , C. Elie , D. Kereselidze et al.
International Journal of Radiation Biology, 2018, 94 (11), pp.975-984. ⟨10.1080/09553002.2018.1493242⟩
Article dans une revue hal-02881819 v1
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Gamma Low-Dose-Rate Ionizing Radiation Stimulates Adaptive Functional and Molecular Response in Human Aortic Endothelial Cells in a Threshold-, Dose-, and Dose Rate-Dependent Manner.

Juliana Vieira Dias , Celine Gloaguen , Dimitri Kereselidze , Line Manens , Karine Tack et al.
Dose-Response, 2018, 16, pp.NC. ⟨10.1177/1559325818755238⟩
Article dans une revue hal-02801537 v1

Enhanced gene delivery to the lung using biodegradable polyunsaturated cationic phosphatidylcholine-detergent conjugates

Philippe Pierrat , Dimitri Kereselidze , Marie Lux , Luc Lebeau , Françoise Pons
International Journal of Pharmaceutics, 2016, 511 (1), pp.205-218. ⟨10.1016/j.ijpharm.2016.07.012⟩
Article dans une revue hal-02000439 v1

Cationic DOPC-Detergent Conjugates for Safe and Efficient in Vitro and in Vivo Nucleic Acid Delivery

Philippe Pierrat , Anne Casset , Pascal Didier , Dimitri Kereselidze , Marie Lux et al.
ChemBioChem, 2016, 17 (18), pp.1771-1783. ⟨10.1002/cbic.201600302⟩
Article dans une revue istex hal-02361380 v1

In vivo exposure to uranium induces reversible and irreversible effects on gene expression and epigenetics in adult male rats

M. Souidi , C. Gloaguen , O. Ibegazene , D. Kereselidze , S. Grison et al.
Toxicology Letters, 2016, 259, pp.S171. ⟨10.1016/j.toxlet.2016.07.407⟩
Article dans une revue irsn-03820488 v1

DOPC-Detergent Conjugates: Fusogenic Carriers for Improved In Vitro and In Vivo Gene Delivery

Philippe Pierrat , Anne Casset , Dimitri Kereselidze , Marie Lux , Françoise Pons et al.
Macromolecular Bioscience, 2016, 16 (7), pp.984-989. ⟨10.1002/mabi.201600012⟩
Article dans une revue istex hal-02000425 v1

Multigenerational effects of chronic low-dose natural uranium contamination: Epigenetic inheritance of methylation signature

G. Elmhiri , C. Gloaguen , D. Kereselidze , S. Grison , A. Legendre et al.
Toxicology Letters, 2016, 259, pp.S114. ⟨10.1016/j.toxlet.2016.07.293⟩
Article dans une revue hal-03820726 v1
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Efficient in vitro and in vivo pulmonary delivery of nucleic acid by carbon dot-based nanocarriers

Philippe Pierrat , Rongrong Wang , Dimitri Kereselidze , Marie Lux , Pascal Didier et al.
Biomaterials, 2015, 51, pp.290-302. ⟨10.1016/j.biomaterials.2015.02.017⟩
Article dans une revue hal-02000419 v1

Bioresponsive Deciduous-Charge Amphiphiles for Liposomal Delivery of DNA and siRNA

Philippe Pierrat , Dimitri Kereselidze , Patrick Wehrung , Guy Zuber , Françoise Pons et al.
Pharmaceutical Research, 2013, 30 (5), pp.1362-1379. ⟨10.1007/s11095-013-0976-9⟩
Article dans une revue istex hal-02361391 v1

Multigenerational epigenetic and metabolomic effects of internal exposure to non-toxic doses of uranium in rats

Stephane Grison , Audrey Legendre , Celine Gloaguen , Dimitri Kereselidze , Christelle Elie et al.
IRPA 16 - International Congress - International Radiation Protection Association - Health Physics Society, IRPA (International Radiation Protection Association), Jul 2024, Orlando, Florida, United States
Communication dans un congrès irsn-04764611 v1

Des Nanoparticules multimodales pour optimiser la radiothérapie

Xiaomin Yang , Sandrine Lacombe , Vu Long Tran , Dimitri Kereselidze , Charles Truillet et al.
Workshop Nanoparticules, 2022, Clermont - Ferrand, France
Communication dans un congrès hal-04430725 v1
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Etude de l’implication du stress dans la réponse aux faibles doses de rayonnements ionisants sur le système cardio et cérébrovasculaire. : Projet SIROCCO

Helene Quelquejay , Virginie Monceau , Stephane Grison , Christelle Durand , Chrystelle Ibanez et al.
Société Francophone de Santé et Environnement, SFSE, Nov 2020, LILLE, France
Communication dans un congrès hal-03106508 v1
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In vivo comparison between two nephrotoxic agents, sodium fluoride and uranyl nitrate: phenotypic aspects and molecular mechanisms involved

Alice Bontemps , Laurine Conquet , Christelle Elie , Victor Magneron , Celine Gloaguen et al.
International Conference on the Health Effects of Incorporated Radionuclides, HEIR, Oct 2019, FONTENAY-AUX-ROSES, France. pp.05004, ⟨10.1051/bioconf/20191405004⟩
Communication dans un congrès hal-02635732 v1

Effect of Caesium-137 chronic low dose exposure on neovascularization

Saloua Dimassi , Dimitri Kereselidze , Victor Magneron , Louison Beugnies , Amandine Sache et al.
International Congress of Radiation Research, ICRR, Aug 2019, MANCHESTER, United Kingdom
Communication dans un congrès hal-02476734 v1
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Mise en place d'un modèle de cancer pulmonaire orthotopique pour la validation méthodologique par ImmunoTEP

Dimitri Kereselidze , Lea Zimmermann , Benoît Jego , Yoann Fontyn , Simon Specklin et al.
AFSTAL 2023, Jul 2023, Bordeaux, France.
Poster de conférence cea-04252026 v1

Biodistribution and pharmacokinetic evaluation of different mAb formats, targeting endothelin A receptor-positive glioblastoma stem cells using in vivo immunoPET imaging

Marie Hautiere , D. Vivier , Donovan Pineau , Amaury Herbet , N. Costa et al.
35th Annual Congress of the European Association of Nuclear Medicine (EANM '22), Oct 2022, Barcelone, Spain. Springer, European Journal of Nuclear Medicine and Molecular Imaging, 49 (Suppl 1), pp.S356-S357, EPS-142, 2022
Poster de conférence hal-04760511 v1
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Effects of low dose radiation on atherosclerosis in APOE(-/-) mice: study of short term effects on macrophage polarization

Nicolas Rey , Talin Ebrahimian , Celine Gloaguen , Dimitri Kereselidze , Christelle Demarquay et al.
ERPW21 - 5th European Radiation Protection Week, Nov 2021, Vienne, Austria.
Poster de conférence hal-04021267 v1

Multimodal analysis of small size data to understand the effects of low doses of ionizing radiation on atherosclerosis

Macine Bachir Abdelouahab , Nicolas Rey , Talin Ebrahimian , Celine Gloaguen , Dimitri Kereselidze et al.
JOBIM2021 - Journées Ouvertes en Biologie, Informatique et Mathématiques, Jul 2021, Paris, France. , Proceedings of JOBIM 2021
Poster de conférence irsn-04740064 v1
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Effects of ionizing radiation on learning and spatial memory after postnatal mouse brain exposure at low to moderate doses

Celine Serrano , Morgane dos Santos , Dimitri Kereselidze , Philippe Lestaevel , Roseline Poirier et al.
NeuroFrance2019, FENS, May 2019, MARSEILLE, France. 2019
Poster de conférence hal-02507246 v1
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Effects of ionizing radiation on learning and spatial memory after postnatal mouse brain exposure at low to moderate doses

Celine Serrano , Morgane dos Santos , Dimitri Kereselidze , Louison Beugnies , Philippe Lestaevel et al.
Radiation Research Society, RRS, Nov 2019, SAN DIEGO, United States. 2019
Poster de conférence hal-02507247 v1
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In vivo comparison between two nephrotoxic agents, sodium fluoride and uranyl nitrate: phenotypic aspects and molecular mechanisms involved

Alice Bontemps , Laurine Conquet , Christelle Elie , Victor Magneron , Celine Gloaguen et al.
Congress of the European Societies of Toxicology, EUROTOX, Sep 2018, BRUXELLES, Belgium. 2018
Poster de conférence hal-02635544 v1

Bio-labile DOPC-based cationic lipids for gene delivery

Philippe Pierrat , D Kereselidze , Francoise Pons-Lebeau , Luc Lebeau
Proceedings of the Genetic Transformation Technologies (Plants and Animals): Plant Genetics and Breeding Technologies: Plant Diseases and Resistance Mechanisms, MEDIMOND S R L, pp.7-11, 2013, 978-88-7587-682-1
Chapitre d'ouvrage hal-02973209 v1