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Elisabeth Davioud-Charvet

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Efficient Multigram-Scale Synthesis of 7-Substituted 3-Methyltetral-1-ones and 6-Fluoromenadione

Nathan Trometer , Matthieu Roignant , Elisabeth Davioud-Charvet
Organic Process Research and Development, 2022, acs.oprd.1c00421. ⟨10.1021/acs.oprd.1c00421⟩
Journal articles hal-03584209v1
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Evaluation of ferrocenyl-containing γ-hydroxy-γ-lactam-derived tetramates as potential antiplasmodials

Nicolas Chopin , Julien Bosson , Shinya Iikawa , Stéphane Picot , Anne-Lise Bienvenu et al.
European Journal of Medicinal Chemistry, 2022, 243, pp.114735. ⟨10.1016/j.ejmech.2022.114735⟩
Journal articles hal-03798632v1
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Magnesium Complexes of Ladanein: A Beneficial Strategy for Stabilizing Polyphenolic Antivirals

Xavier Martin‐benlloch , Don Antoine Lanfranchi , Sibylle Haid , Thomas Pietschmann , Elisabeth Davioud‐charvet et al.
European Journal of Inorganic Chemistry, 2021, 2021 (27), pp.2764-2772. ⟨10.1002/ejic.202100341⟩
Journal articles hal-03357249v1
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Recent Advances in Direct C‐H Radical Alkylation of 1,4‐Quinones

Maxime Donzel , Deniz Karabiyikli , Leandro Cotos Munoz , Mourad Elhabiri , Elisabeth Davioud-Charvet et al.
European Journal of Organic Chemistry, 2021, 2021 (25), pp.3622-3633. ⟨10.1002/ejoc.202100452⟩
Journal articles hal-03249134v1
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The parasitophorous vacuole nutrient channel is critical for drug access in malaria parasites and modulates the artemisinin resistance fitness cost

Paolo Mesén-Ramírez , Bärbel Bergmann , Mourad Elhabiri , Lei Zhu , Heidrun von Thien et al.
Cell Host & Microbe, 2021, 29 (12), pp.1774-1787.e9. ⟨10.1016/j.chom.2021.11.002⟩
Journal articles hal-03544974v1
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Bioinspired Photoredox Benzylation of Quinones

Maxime Donzel , Mourad Elhabiri , Elisabeth Davioud-Charvet
Journal of Organic Chemistry, 2021, 86 (15), pp.10055-10066. ⟨10.1021/acs.joc.1c00814⟩
Journal articles hal-03369963v1
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A Class of Valuable (Pro-)Activity-Based Protein Profiling Probes: Application to the Redox-Active Antiplasmodial Agent, Plasmodione

Bogdan Cichocki , Vrushali Khobragade , Maxime Donzel , Leandro Cotos Munoz , Stephanie Blandin et al.
JACS Au, 2021, 1 (5), pp.669-689. ⟨10.1021/jacsau.1c00025⟩
Journal articles hal-03243960v1
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Plasmodium falciparum Ferredoxin-NADP + Reductase-Catalyzed Redox Cycling of Plasmodione Generates Both Predicted Key Drug Metabolites: Implication for Antimalarial Drug Development

Bogdan Cichocki , Maxime Donzel , Kim C. Heimsch , Mindaugas Lesanavičius , Liwen Feng et al.
ACS Infectious Diseases, In press, ⟨10.1021/acsinfecdis.1c00054⟩
Journal articles hal-03243991v1
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A role for the succinate dehydrogenase in the mode of action of the redox-active antimalarial drug, plasmodione

Pierre Mounkoro , Thomas Michel , Marie-Pierre Golinelli-Cohen , Stephanie Blandin , Elisabeth Davioud-Charvet et al.
Free Radical Biology and Medicine, 2021, ⟨10.1016/j.freeradbiomed.2020.11.010⟩
Journal articles hal-03026255v1
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Repurposing Auranofin and Evaluation of a New Gold(I) Compound for the Search of Treatment of Human and Cattle Parasitic Diseases: From Protozoa to Helminth Infections

Liwen Feng , Sébastien Pomel , Perle Latre de Late , Alexandre Taravaud , Philippe M Loiseau et al.
Molecules, 2020, 25 (21), pp.5075. ⟨10.3390/molecules25215075⟩
Journal articles hal-03038691v1

Antiplasmodial Activity of Nitroaromatic Compounds: Correlation with Their Reduction Potential and Inhibitory Action on Plasmodium falciparum Glutathione Reductase

Audronė Marozienė , Mindaugas Lesanavičius , Elisabeth Davioud-Charvet , Alessandro Aliverti , Philippe Grellier et al.
Molecules, 2019, 24 (24), pp.4509. ⟨10.3390/molecules24244509⟩
Journal articles mnhn-02867389v1
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Antiplasmodial Activity of Nitroaromatic Compounds: Correlation with Their Reduction Potential and Inhibitory Action on Plasmodium falciparum Glutathione Reductase

Audronė Marozienė , Mindaugas Lesanavičius , Elisabeth Davioud-Charvet , Alessandro Aliverti , Philippe Grellier et al.
Molecules, 2019, 24 (24), pp.4509. ⟨10.3390/molecules24244509⟩
Journal articles hal-03038823v1
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A Mild and Versatile Friedel‐Crafts Methodology for the Diversity‐Oriented Synthesis of Redox‐Active 3‐Benzoylmenadiones with Tuneable Redox Potentials

Leandro Cotos , Maxime Donzel , Mourad Elhabiri , Elisabeth Davioud-Charvet
Chemistry - A European Journal, 2019, 26 (15), pp.3314-3325. ⟨10.1002/chem.201904220⟩
Journal articles hal-02408960v1

Selenium Status in Elderly People: Longevity and Age-Related Diseases

Harry Robberecht , Tess de Bruyne , Elisabeth Davioud-Charvet , John Mackrill , Nina Hermans et al.
Current Pharmaceutical Design, 2019, 25 (15), pp.1694-1706. ⟨10.2174/1381612825666190701144709⟩
Journal articles hal-02325568v1

Author Correction: Arylmethylamino steroids as antiparasitic agents

Reimar Krieg , Esther Jortzik , Alice-Anne Goetz , Stéphanie Blandin , Sergio Wittlin et al.
Nature Communications, 2019, 10 (1), ⟨10.1038/s41467-019-11018-x⟩
Journal articles hal-02325972v1
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Investigating the mode of action of the redox-active antimalarial drug plasmodione using the yeast model

Pierre Mounkoro , Thomas Michel , Stéphanie Blandin , Marie-Pierre Golinelli-Cohen , Elisabeth Davioud-Charvet et al.
Free Radical Biology and Medicine, 2019, 141, pp.269-278. ⟨10.1016/j.freeradbiomed.2019.06.026⟩
Journal articles hal-02170571v1

Physicochemical Properties Govern the Activity of Potent Antiviral Flavones

Xavier Martin-Benlloch , Sibylle Haid , Alexandra Novodomska , Frank Rominger , Thomas Pietschmann et al.
ACS Omega, 2019, 4 (3), pp.4871-4887. ⟨10.1021/acsomega.8b03332⟩
Journal articles hal-02325555v1

Synthesis of plasmodione metabolites and 13C-enriched plasmodione as chemical tools for drug metabolism investigation

Liwen Feng , Don Antoine Lanfranchi , Leandro Cotos Munoz , Elena Cesar Rodo , Katharina Ehrhardt et al.
Organic & Biomolecular Chemistry, 2018, 16, pp.2647-2665. ⟨10.1039/C8OB00227D⟩
Journal articles hal-02161631v1

AntiMalarial Mode of Action (AMMA) Database: Data Selection, Verification and Chemical Space Analysis

Pavel Sidorov , Elisabeth Davioud-Charvet , Gilles Marcou , Dragos Horvath , Alexandre Varnek et al.
Molecular Informatics, 2018, 37 (9-10), pp.1800021. ⟨10.1002/minf.201800021⟩
Journal articles hal-02325960v1

Iron(iii) coordination properties of ladanein, a flavone lead with a broad-spectrum antiviral activity

Xavier Martin Benlloch , D Jacquemin , Elisabeth Davioud-Charvet , Mourad Elhabiri , A Novodomska et al.
New J. Chem., 2018, 42 (10), pp.8074-8087. ⟨10.1039/C7NJ04867J⟩
Journal articles hal-02161640v1

Pharmacomodulation of the antimalarial plasmodione: synthesis of biaryl- and N-arylalkylamine analogues, antimalarial activities and physicochemical properties

Karène Urgin , Mouhamad Jida , Katharina Ehrhardt , T Müller , M Lanzer et al.
Molecules, 2017, 22, pp.1-32. ⟨10.3390/molecules22010161⟩
Journal articles hal-02177398v1

A Redox-Active Fluorescent pH Indicator for Detecting Plasmodium falciparum Strains with Reduced Responsiveness to Quinoline Antimalarial Drugs

Mouhamad Jida , Cecilia Sanchez , Karène Urgin , Katharina Ehrhardt , S Mounien et al.
ACS Infectious Diseases, 2017, 3, pp.119-131. ⟨10.1021/acsinfecdis.5b00141⟩
Journal articles hal-02177403v1

QSAR modeling1. and chemical space analysis of antimalarial compounds

Pavel Sidorov , B Viira , Elisabeth Davioud-Charvet , U Maran , Gilles Marcou et al.
JOURNAL OF COMPUTER-AIDED MOLECULAR DESIGN, 2017, 31, pp.441-451. ⟨10.1007/s10822-017-0019-4⟩
Journal articles hal-02177404v1

A high susceptibility to redox imbalance of the transmissible stages of Plasmodium falciparum revealed with a luciferase-based mature gametocyte assay

G Siciliano , T Kumar , R Bona , G Camarda , M Calabretta et al.
Molecular Microbiology, 2017, 104, pp.306-318. ⟨10.1111/mmi.13626⟩
Journal articles hal-02161655v1

Arylmethylamino steroids as novel antiparasitic agents

R Krieg , E Jortzik , Alice-Anne Goetz , Stephanie Blandin , S Wittlin et al.
Nature Communications, 2017, 8, ⟨10.1038/ncomms14478⟩
Journal articles hal-02158243v1

Redox Polypharmacology as an Emerging Strategy to Combat Malarial Parasites

Pavel Sidorov , Israel Desta , Matthieu Chessé , Dragos Horvath , Gilles Marcou et al.
ChemMedChem, 2016, 11 (12), pp.1339-1351. ⟨10.1002/cmdc.201600009⟩
Journal articles hal-03151671v1
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A Platform of Regioselective Methodologies to Access to Polysubstituted 2-Methyl-1,4-Naphthoquinones Derivatives: Scope and Limitations

Elena Cesar Rodo , Liwen Feng , Mouhamad Jida , Katharina Ehrhardt , Max Bielitza et al.
European Journal of Organic Chemistry, 2016, 2016 (11), pp.1982-1993. ⟨10.1002/ejoc.201600144⟩
Journal articles hal-03537379v1
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In Silico Mining for Antimalarial Structure-Activity Knowledge and Discovery of Novel Antimalarial Curcuminoids

Birgit Viira , Thibault Gendron , Don Antoine Lanfranchi , Sandrine Cojean , Dragos Horvath et al.
Molecules, 2016, 21 (7), pp.853. ⟨10.3390/molecules21070853⟩
Journal articles hal-03150675v1

The Redox Cycler Plasmodione Is a Fast-Acting Antimalarial Lead Compound with Pronounced Activity against Sexual and Early Asexual Blood-Stage Parasites

Katharina Ehrhardt , Christiane Deregnaucourt , Alice-Anne Goetz , Tzvetomira Tzanova , Valentina Gallo et al.
Antimicrobial Agents and Chemotherapy, 2016, 60 (9), pp.5146-5158. ⟨10.1128/AAC.02975-15⟩
Journal articles hal-01455775v1

Double-drug development against antioxidant enzymes from Plasmodium falciparum

Christophe Biot , Jean Dessolin , Philippe Grellier , Elisabeth Davioud-Charvet
Redox Report, 2013, 8 (5), pp.280-283. ⟨10.1179/135100003225002916⟩
Journal articles mnhn-02867482v1

Exploring the trifluoromenadione core as a template to design antimalarial redox-active agents interacting with glutathione reductase

D.A. Lanfranchi , D. Belorgey , T. Müller , H. Vezin , M. Lanzer et al.
Organic & Biomolecular Chemistry, 2012, 10, pp.4795 - 4806. ⟨10.1039/C2OB25229E⟩
Journal articles hal-00702812v1
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A Glutathione Reductase-Catalyzed Cascade of Redox Reactions to Bioactivate Potent Antimalarial 1,4-Naphthoquinones - A New Strategy to Combat Malarial Parasites

Tobias Müller , Laure Johann , Beate Jannack , Margit Brückner , Don Antoine Lanfranchi et al.
Journal of the American Chemical Society, 2011, 133 (30), pp.11557-11571. ⟨10.1021/ja201729z⟩
Journal articles hal-03406270v1

Antimalarial activities of ferroquine conjugates with either glutathione reductase inhibitors or glutathione depletors via a hydrolyzable amide linker

Natascha Chavain , Elisabeth Davioud-Charvet , Xavier Trivelli , Linda Mbeki , M. Rottmann et al.
Bioorganic and Medicinal Chemistry, 2009, 17 (23), pp.8048-8059. ⟨10.1016/j.bmc.2009.10.008⟩
Journal articles hal-00642006v1

The aza-analogues of 1,4-naphthoquinones are potent substrates and inhibitors of plasmodial thioredoxin and glutathione reductases and of human erythrocyte glutathione reductase

Christophe Morin , Tatiana Besset , Jean-Claude Moutet , Martine Fayolle , Margit Brückner et al.
Organic & Biomolecular Chemistry, 2008, 6 (15), pp.2731. ⟨10.1039/B802649C⟩
Journal articles hal-02541797v1

Undressing of Phosphine Gold(I) Complexes as Irreversible Inhibitors of Human Disulfide Reductases

Sabine Urig , Karin Fritz-Wolf , Régis Réau , Christel Herold-Mende , Katalin Tóth et al.
Angewandte Chemie International Edition, 2006, 45 (12), pp.1881-1886. ⟨10.1002/anie.200502756⟩
Journal articles hal-01090379v1

A Fluoro Analogue of the Menadione Derivative 6-[2‘-(3‘-Methyl)-1‘,4‘-naphthoquinolyl]hexanoic Acid Is a Suicide Substrate of Glutathione Reductase. Crystal Structure of the Alkylated Human Enzyme†

Holger Bauer , Karin Fritz-Wolf , Andreas Winzer , Sebastian Kühner , Susan Little et al.
Journal of the American Chemical Society, 2006, The Journal of physical chemistry, 128 (33), pp.10784-10794. ⟨10.1021/ja061155v⟩
Journal articles hal-03378811v1

Trypanosoma cruzi prolyl oligopeptidase Tc80 is involved in nonphagocytic mammalian cell invasion by trypomastigotes.

P. Grellier , S. Vendeville , R. Joyeau , I. M. D. Bastos , H. Drobecq et al.
Journal of Biological Chemistry, 2001, 276, pp.47078-47086
Journal articles hal-00086392v1

Glutathione-dependent activities of $Trypanosoma\ cruzi$ p52 makes it a new member of the thiol:disulphide oxidoreductase family

Mireille Moutiez , Eric Quéméneur , Christian Sergheraert , Valérie Lucas , André Tartar et al.
Biochemical Journal, 1997, 322 (1), pp.43-48. ⟨10.1042/bj3220043⟩
Journal articles hal-03637701v1

High sensitivity to auxin is a common feature of hairy root

W.H. Shen , E. Davioud , C. David , H. Barbier-Brygoo
Plant Physiology, 1990, 94, pp.554-560
Journal articles hal-02713794v1

Production of indole alkaloids by in vitro root cultures from Catharanthus trichophyllus

E. Davioud , C. Kan , J. Hamon , J. Tempe , H.P. Husson et al.
Phytochemistry, 1989, 28 (10), pp.2675-2680
Journal articles hal-02722026v1

Cucumopine. A new T-DNA- encoded opine in hairy root and crown-gall

E. Davioud , A. Petit , M.E. Tate , M.H. Ryder , J. Tempe et al.
Phytochemistry, 1988, 27 (8), pp.2429-2433
Journal articles hal-02727299v1

Structure and synthesis of cucumopine, a new crown gall and hairy-root opine

E. Davioud , J.C. Quirion , M.E. Tate , J. Tempe , H.P. Husson et al.
Heterocycles, 1988, 27 (10), n.p
Journal articles hal-02716461v1