Estelle Duprez

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Présentation

Estelle DUPREZ
estelle.duprez@inserm.fr
French nationality

2 children

POSITION**:**

Directeur de Recherche, deuxième classe, DR2 CNRS

Team leader of the Team: Epigenetic factors in normal and malignant hematopoiesis, CRCM, IPC, U-1068 INSERM, UMR 7258 CNRS, Aix Marseille University.

EDUCATION**:**
1990- Maîtrise de Biochimie. Paris VI. Mention assez bien
1991- D.E.A. d'Endocrinologie et interactions cellulaires. Paris XI. Mention bien.

1995- Doctorat de l'université PARIS XI. Mention très honorable avec félicitations du jury
2008-HDR de Aix-Marseille Université

ACADEMIC APPOINTMENTS**:**
1992-1995 PhD fellow, Unité INSERM U-301 Hôpital St Louis, PARIS.
Financial support: Bourse MRT, Bourse ARC.
1996-1997 Postdoctoral fellow Paul Freemont Lab Imperial Cancer Research Fund, LondonFinancial support: Bourse individuelle "Capital Humain et Mobilité" de la CE.

1998-Chargé de recherche (CR2) CNRS. INSERM U-496, Hopital Saint-Louis, Paris.
1999-2002-Détachement, Division of Hematology/ Oncology Harvard Institute of Medicine, Boston, USA, Dan Tenen Lab.

2003-2009-Chargé de recherche (CR1) Mickael Sieweke lab. Centre d’Immunologie de Marseille Luminy.

2010-2011- Chargé de recherche (CR1) CRCM IPC, U-1068 INSERM, UMR 7258 CNRS, Marseille.

2012-Now- Directeur de recherche (DR2) Group leader: Epigenetic factors in normal and malignant hematopoiesis. CRCM IPC, U-1068 INSERM, UMR 7258 CNRS, Marseille

SCIENTIFIC PRODUCTION:

52 Publications, 37 articles > 2100 citations, h index=22,

1 patent, WO2015169906-A1, 1 patent in preparation

Expertise/consulting, grant evaluation:

Expert for Leukaemia & Lymphoma Research Foundation LRF, England (2010-13), Cancéropôle Grandouest (2011), Celgene Corporation (2011), European Hematology Association (EHA) (2012-13; 2015), INSERM Contrat Interface Hospitalier (2012-13-2015), Scientific committee of LLC IDF (2013-16), Association Laurette Fugain (2014- ), Fondation de France (2016- ), Fondation Recherche Médical (2018-2021). Member of SFH. Member of the CHO organisation (2014-2017 ; treasurer 2016-17).

Reviewer for : Journal of Experimental Medicine, PLoS Genetics, Cancer Research, Leukemia, Blood.

TEACHING/MENTORING:

Master Development & Immunity (3 days/year) and Master Human Pathology (2 day/year) Aix-Marseille-University.

Member of M2 jury (2012; 2013; 2016 ;2019). Since 2008, Member of 9 PhD thesis/HDR jury.

Mentor of 16 M1/M2 students, 2 Post-docs, Director of 7 PhD students, « Tuteur » of 2 PhD,

Invited conferences:

-EHA, Stokholm, 2013, Epigenetic profiling in AML

-HEMID, Milan, Juin 2012, Polycomb Repressive Complexes in hematopoiesis

-17ème congrès de CHO, Les Embiez, Septembre 2011

-International Florence Meeting in Hematology, Florence, 2010

-EHA, Berlin, Juin 2009, PRC in APL

SELECTED PUBLICATIONS :

Zidi, B., Vincent-FabertC., Pouyet, L., Seillier, M., Vandevelde, A., N’guessan, P., Guittard, G., Mancini, S., Duprez, E***., Carrier, A*. TP53INP1 deficiency maintains murine B lymphopoiesis in aged bone marrow through redox controlled IL-7R/STAT5 signaling.(PNAS, in pres*s). * Co-last and corresponding authorsKoubi, M., Poplineau M., Vernerey, J., N’Guyen L., El-Kaoutari, A., Garciaz, S., Tiberi, G., Maqbool MA, Andrau JC, Guillouf C., Saurin, A., Duprez E. Regulation of the positive transcriptional effect of PLZF through a non-canonical EZH2 activity. Nucleic Acids Res doi: 10.1093/nar/gky080. (2018) PMID: 29425303Vincent-FabertC, PlatetN., Vandevelde, A., Poplineau M., Koubi, M., Finetti., P, Tiberi, G., Imbert, AM., Bertucci, F., Duprez, E. PLZF mutation alters mouse hematopoietic stem cell function and cell cycle progression 14;127:1881-5*,* Blood (2016).Kuhnl A, Valk PJ, Sanders MA, Ivey A, Hills RK, Mills KI, Gale RE, Kaiser MF, Dillon R, Joannides M, Gilkes A, Haferlach T, Schnittger S, Duprez E, Linch DC, Delwel R, Lowenberg B, Baldus CD, Solomon E, Burnett AK et al. Downregulation of the Wnt inhibitor CXXC5 predicts a better prognosis in acute myeloid leukemia. Blood 125: 2985-94 (2015).Navarro, JM, Touzard, A, Pradel, L, Loosveld, M, Koubi, M, Fenouil, R, Le Noir, S, Ahmad Maqboo, M, Morgado, E,, Gregoire, C, Jaeger, S, Mamessier, E, Pignon, C, Hacein-Bey, S, Malissen, B Gut,M Gut,I, Dombret, H, Macintyre, E, Howes, S, Thrasher, A, Ifrah, N, Payet-Bornet, D, Duprez, E*, Andrau, JC*, Asnafi, V*, and Nadel,B*. Site-& allele-specific de-silencing of polycomb repressive activity by insertional oncogenesis: a new recurrent mechanism of TAL1 activation in T-ALL. Nat Commun, 23;6: 6094 (2015). * Equal contribution.Tiberi, G, Pekowska, A, Oudin, C, Ivey, A, Prebet, T, Koubi, M, Lembo, F, Mozziconacci, MJ, Bidaut, G, Autret, A, Chabannon, C, Grimwade, D, Vey, N, Spicuglia, S, Calmels, B, Duprez, E. PcG methylation of the HIST1 cluster defines an epigenetic marker of Acute Myeloid Leukemia. Leukemia,* Dec 8. doi: 10.1038/leu.2014.339 (2015).Sarrazin S, Mossadegh-Keller, N Fukao T, Mossadegh-Keller, N, Aziz, A, Mourcin, F, Vanhille L, Kelly-Modis L, Kastern P, Chan S, Duprez E, Otto C, Sieweke M. MafB restricts m-CSF dependent Myeloid committment divsions of hematopoietic stem cells. Cell, 138: 300-13 (2009).Boukarabila H, Saurin A, Batsché E, Mossadegh N, VanLohuizen M, Otte A, Pradel J, Muchardt C, Sieweke M, Duprez E. The PRC1 Polycomb group complex interacts with PLZF/RARA to mediate leukemic transformation. Genes Dev, 23: 1195-1206 (2009).

Publications

Publications

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Gene expression-based rationale for investigating CDK4/6 inhibitors in primitive myelofibrosis

Anne Murati , Pascal Finetti , Estelle Duprez , Jérôme Rey , Emilie Mamessier et al.

Leukemia, 2025, 39, pp.2299-2301. ⟨10.1038/s41375-025-02669-5⟩

Article dans une revue hal-05147704v1
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Predictive modelling of acute Promyelocytic leukaemia resistance to retinoic acid therapy

José A Sánchez-Villanueva , Lia N’guyen , Mathilde Poplineau , Estelle Duprez , Élisabeth Remy et al.

Briefings in Bioinformatics, 2024, 26 (1), ⟨10.1093/bib/bbaf002⟩

Article dans une revue hal-04905666v1
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Direct presentation of inflammation-associated self-antigens by thymic innate-like T cells induces elimination of autoreactive CD8+ thymocytes

Yuanyuan You , Josefine Dunst , Kewei Ye , Patrick Sandoz , Annika Reinhardt et al.

Nature Immunology, 2024, 25 (8), pp.1367-1382. ⟨10.1038/s41590-024-01899-6⟩

Article dans une revue hal-04762068v1

Pharmacologic Reduction of Mitochondrial Iron Triggers a Noncanonical BAX/BAK-Dependent Cell Death

Sylvain Garciaz , Andrew Guirguis , Sebastian Müller , Fiona Brown , Yih-Chih Chan et al.

Cancer Discovery, 2023

Article dans une revue hal-05344093v1
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Logical modelling of myelofibrotic microenvironment predicts dysregulated progenitor stem cell crosstalk

Stephen Chapman , Estelle Duprez , Elisabeth Remy

BioSystems, 2023, 231, pp.104961. ⟨10.1016/j.biosystems.2023.104961⟩

Article dans une revue hal-04762151v1
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Pharmacologic Reduction of Mitochondrial Iron Triggers a Noncanonical BAX/BAK-Dependent Cell Death

Sylvain Garciaz , Andrew Guirguis , Sebastian Müller , Fiona Brown , Yih-Chih Chan et al.

Cancer Discovery, 2022, 12 (3), pp.774-791. ⟨10.1158/2159-8290.CD-21-0522⟩

Article dans une revue hal-03821713v1
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HDAC1 and PRC2 mediate combinatorial control in SPI1/PU.1-dependent gene repression in murine erythroleukaemia

Sebastian Gregoricchio , Lélia Polit , Michela Esposito , Jérémy Berthelet , Laure Delestré et al.

Nucleic Acids Research, 2022, 50 (14), pp.7938-7958. ⟨10.1093/nar/gkac613⟩

Article dans une revue hal-03821715v1
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Non-canonical EZH2 drives retinoic acid resistance of variant acute promyelocytic leukemias

Mathilde Poplineau , Nadine Platet , Adrien Mazuel , Léonard Hérault , Lia N’guyen et al.

Blood, 2022, 140 (22), pp.2358-2370. ⟨10.1182/blood.2022015668⟩

Article dans une revue hal-03821719v1
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A novel Boolean network inference strategy to model early hematopoiesis aging

Léonard Hérault , Mathilde Poplineau , Estelle Duprez , Élisabeth Remy

Computational and Structural Biotechnology Journal, 2022, 21, pp.21-33. ⟨10.1016/j.csbj.2022.10.040⟩

Article dans une revue hal-04277075v1
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Single Cell Transcriptomics to Understand HSC Heterogeneity and Its Evolution upon Aging

Léonard Hérault , Mathilde Poplineau , Elisabeth Remy , Estelle Duprez

Cells, 2022, 11 (19), pp.3125. ⟨10.3390/cells11193125⟩

Article dans une revue hal-03835100v1

Mining old transcriptomes to predict HSC age

Mathilde Poplineau , Estelle Duprez

Blood, 2021, 138 (6), pp.422-423. ⟨10.1182/blood.2021012002⟩

Article dans une revue hal-03835106v1

Mining old transcriptomes to predict HSC age

Estelle Duprez , Mathilde Poplineau

Blood, 2021, 138 (6), pp.422-423. ⟨10.1182/blood.2021012002⟩

Article dans une revue hal-03436319v1
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Epigenetic down-regulation of the HIST1 locus predicts better prognosis in acute myeloid leukemia with NPM1 mutation

Sylvain Garciaz , Lia N’guyen Dasi , Pascal Finetti , Christine Chevalier , Julien Vernerey et al.

Clinical Epigenetics, 2019, 11 (1), ⟨10.1186/s13148-019-0738-6⟩

Article dans une revue hal-02322283v1
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PLZF limits enhancer activity during hematopoietic progenitor aging

Mathilde Poplineau , Julien Vernerey , Nadine Platet , Lia N'Guyen , Léonard Hérault et al.

Nucleic Acids Research, 2019, 47 (9), pp.4509-4520. ⟨10.1093/nar/gkz174⟩

Article dans une revue hal-02145730v1
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TP53INP1 deficiency maintains murine B lymphopoiesis in aged bone marrow through redox-controlled IL-7R/STAT5 signaling

Bochra Zidi , Christelle Vincent-Fabert , Laurent Pouyet , Marion Seillier , Amelle Vandevelde et al.

Proceedings of the National Academy of Sciences of the United States of America, 2019, 116 (1), pp.211-216. ⟨10.1073/pnas.1809980116⟩

Article dans une revue hal-02145737v1
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Nidogen-1 Contributes to the Interaction Network Involved in Pro-B Cell Retention in the Peri-sinusoidal Hematopoietic Stem Cell Niche

Marielle Balzano , Maria de Grandis , Thien-Phong Vu Manh , Lionel Chasson , Florence Bardin et al.

Cell Reports, 2019, 26 (12), pp.3257-3271.e8. ⟨10.1016/j.celrep.2019.02.065⟩

Article dans une revue hal-02504005v1

TP53INP1 deficiency maintains murine B lymphopoiesis in aged bone marrow through redox-controlled IL-7R/STAT5 signaling

Bochra Zidi , Christelle Vincent-Fabert , Laurent Pouyet , Marion Seillier , Amelle Vandevelde et al.

Proceedings of the National Academy of Sciences of the United States of America, 2018, 116 (1), pp.211-216. ⟨10.1073/pnas.1809980116⟩

Article dans une revue hal-04772663v1
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Regulation of the positive transcriptional effect of PLZF through a non-canonical EZH2 activity

Myriam Koubi , Mathilde Poplineau , Julien Vernerey , Lia N 'Guyen , Guillaume Tiberi et al.

Nucleic Acids Research, 2018, 46 (7), pp.3339-3350. ⟨10.1093/nar/gky080⟩

Article dans une revue hal-01765664v1
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Au cœur d’une complexité biologique EZH2, une protéine du groupe Polycomb.

Myriam Koubi , Christian Chabannon , Estelle Duprez

Médecine/Sciences, 2017, 33 (5), pp.499 - 505. ⟨10.1051/medsci/20173305013⟩

Article dans une revue hal-01787246v1

A hypomorphic mutation in the Gfi1 transcriptional repressor results in a novel form of neutropenia

Diana Ordoñez-Rueda , Friederike Jönsson , David Mancardi , Weidong Zhao , Aurélie Malzac et al.

European Journal of Immunology, 2012, 42 (9), pp.2395-2408. ⟨10.1002/eji.201242589⟩

Article dans une revue pasteur-02518924v1
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Characterisation of Genome-Wide PLZF/RARA Target Genes

Salvatore Spicuglia , Christelle Vincent-Fabert , Touati Benoukraf , Guillaume Tibéri , Andrew J Saurin et al.

PLoS ONE, 2011, 6 (9), pp.e24176. ⟨10.1371/journal.pone.0024176⟩

Article dans une revue hal-00674513v1

The PRC1 Polycomb group complex interacts with PLZF/RARA to mediate leukemic transformation.

Hanane Boukarabila , Andrew J Saurin , Eric Batsché , Noushine Mossadegh , Maarten van Lohuizen et al.

Genes and Development, 2009, 23 (10), pp.1195-206. ⟨10.1101/gad.512009⟩

Article dans une revue hal-00408483v1

MafB restricts M-CSF-dependent myeloid commitment divisions of hematopoietic stem cells.

Sandrine Sarrazin , Noushine Mossadegh , Taro Fukao , Athar Aziz , Frederic Mourcin et al.

Cell, 2009, 138 (2), pp.300-13. ⟨10.1016/j.cell.2009.04.057⟩

Article dans une revue inserm-00420157v1

Distinctive and indispensable roles of PU.1 in maintenance of hematopoietic stem cells and their differentiation.

Hiromi Iwasaki , Chamorro Somoza , Hirokazu Shigematsu , Estelle A Duprez , Junko Iwasaki-Arai et al.

Blood, 2005, 106 (5), pp.1590-600. ⟨10.1182/blood-2005-03-0860⟩

Article dans une revue hal-00187635v1

Role of Promyelocytic Leukemia (Pml) Sumolation in Nuclear Body Formation, 11s Proteasome Recruitment, and as2O3-Induced Pml or Pml/Retinoic Acid Receptor α Degradation

Valérie Lallemand-Breitenbach , Jun Zhu , Francine Puvion , Marcel Koken , Nicole Honoré et al.

Journal of Experimental Medicine, 2001, 193 (12), pp.1361-1372. ⟨10.1084/jem.193.12.1361⟩

Article dans une revue hal-05509862v1

Deciphering EZH2 Non-Canonical Activities in AML Resistance

Lia N'Guyen , Emeline Boet , Camille Montersino , Claire Burny , Stéphane Audebert et al.

The 66th ASH Annual Meeting, Dec 2024, San Diego (CA), United States. 144 (Supplement 1), pp.4097-4097, 2024, ⟨10.1182/blood-2024-200580⟩

Poster de conférence hal-05390918v1