Estelle Duprez
Présentation
Estelle DUPREZ 2 children POSITION**:** Directeur de Recherche, deuxième classe, DR2 CNRS Team leader of the Team: Epigenetic factors in normal and malignant hematopoiesis, CRCM, IPC, U-1068 INSERM, UMR 7258 CNRS, Aix Marseille University. EDUCATION**:** 1995- Doctorat de l'université PARIS XI. Mention très honorable avec félicitations du jury ACADEMIC APPOINTMENTS**:** 1998-Chargé de recherche (CR2) CNRS. INSERM U-496, Hopital Saint-Louis, Paris. 2003-2009-Chargé de recherche (CR1) Mickael Sieweke lab. Centre d’Immunologie de Marseille Luminy. 2010-2011- Chargé de recherche (CR1) CRCM IPC, U-1068 INSERM, UMR 7258 CNRS, Marseille. 2012-Now- Directeur de recherche (DR2) Group leader: Epigenetic factors in normal and malignant hematopoiesis. CRCM IPC, U-1068 INSERM, UMR 7258 CNRS, Marseille SCIENTIFIC PRODUCTION: 52 Publications, 37 articles > 2100 citations, h index=22, 1 patent, WO2015169906-A1, 1 patent in preparation Expertise/consulting, grant evaluation: Expert for Leukaemia & Lymphoma Research Foundation LRF, England (2010-13), Cancéropôle Grandouest (2011), Celgene Corporation (2011), European Hematology Association (EHA) (2012-13; 2015), INSERM Contrat Interface Hospitalier (2012-13-2015), Scientific committee of LLC IDF (2013-16), Association Laurette Fugain (2014- ), Fondation de France (2016- ), Fondation Recherche Médical (2018-2021). Member of SFH. Member of the CHO organisation (2014-2017 ; treasurer 2016-17). Reviewer for : Journal of Experimental Medicine, PLoS Genetics, Cancer Research, Leukemia, Blood. TEACHING/MENTORING: Master Development & Immunity (3 days/year) and Master Human Pathology (2 day/year) Aix-Marseille-University. Member of M2 jury (2012; 2013; 2016 ;2019). Since 2008, Member of 9 PhD thesis/HDR jury. Mentor of 16 M1/M2 students, 2 Post-docs, Director of 7 PhD students, « Tuteur » of 2 PhD, Invited conferences: -EHA, Stokholm, 2013, Epigenetic profiling in AML -HEMID, Milan, Juin 2012, Polycomb Repressive Complexes in hematopoiesis -17ème congrès de CHO, Les Embiez, Septembre 2011 -International Florence Meeting in Hematology, Florence, 2010 -EHA, Berlin, Juin 2009, PRC in APL SELECTED PUBLICATIONS : Zidi, B., Vincent-FabertC., Pouyet, L., Seillier, M., Vandevelde, A., N’guessan, P., Guittard, G., Mancini, S., Duprez, E***., Carrier, A*. TP53INP1 deficiency maintains murine B lymphopoiesis in aged bone marrow through redox controlled IL-7R/STAT5 signaling.(PNAS, in pres*s). * Co-last and corresponding authorsKoubi, M., Poplineau M., Vernerey, J., N’Guyen L., El-Kaoutari, A., Garciaz, S., Tiberi, G., Maqbool MA, Andrau JC, Guillouf C., Saurin, A., Duprez E. Regulation of the positive transcriptional effect of PLZF through a non-canonical EZH2 activity. Nucleic Acids Res doi: 10.1093/nar/gky080. (2018) PMID: 29425303Vincent-FabertC, PlatetN., Vandevelde, A., Poplineau M., Koubi, M., Finetti., P, Tiberi, G., Imbert, AM., Bertucci, F., Duprez, E. PLZF mutation alters mouse hematopoietic stem cell function and cell cycle progression 14;127:1881-5*,* Blood (2016).Kuhnl A, Valk PJ, Sanders MA, Ivey A, Hills RK, Mills KI, Gale RE, Kaiser MF, Dillon R, Joannides M, Gilkes A, Haferlach T, Schnittger S, Duprez E, Linch DC, Delwel R, Lowenberg B, Baldus CD, Solomon E, Burnett AK et al. Downregulation of the Wnt inhibitor CXXC5 predicts a better prognosis in acute myeloid leukemia. Blood 125: 2985-94 (2015).Navarro, JM, Touzard, A, Pradel, L, Loosveld, M, Koubi, M, Fenouil, R, Le Noir, S, Ahmad Maqboo, M, Morgado, E,, Gregoire, C, Jaeger, S, Mamessier, E, Pignon, C, Hacein-Bey, S, Malissen, B Gut,M Gut,I, Dombret, H, Macintyre, E, Howes, S, Thrasher, A, Ifrah, N, Payet-Bornet, D, Duprez, E*, Andrau, JC*, Asnafi, V*, and Nadel,B*. Site-& allele-specific de-silencing of polycomb repressive activity by insertional oncogenesis: a new recurrent mechanism of TAL1 activation in T-ALL. Nat Commun, 23;6: 6094 (2015). * Equal contribution.Tiberi, G, Pekowska, A, Oudin, C, Ivey, A, Prebet, T, Koubi, M, Lembo, F, Mozziconacci, MJ, Bidaut, G, Autret, A, Chabannon, C, Grimwade, D, Vey, N, Spicuglia, S, Calmels, B, Duprez, E. PcG methylation of the HIST1 cluster defines an epigenetic marker of Acute Myeloid Leukemia. Leukemia,* Dec 8. doi: 10.1038/leu.2014.339 (2015).Sarrazin S, Mossadegh-Keller, N Fukao T, Mossadegh-Keller, N, Aziz, A, Mourcin, F, Vanhille L, Kelly-Modis L, Kastern P, Chan S, Duprez E, Otto C, Sieweke M. MafB restricts m-CSF dependent Myeloid committment divsions of hematopoietic stem cells. Cell, 138: 300-13 (2009).Boukarabila H, Saurin A, Batsché E, Mossadegh N, VanLohuizen M, Otte A, Pradel J, Muchardt C, Sieweke M, Duprez E. The PRC1 Polycomb group complex interacts with PLZF/RARA to mediate leukemic transformation. Genes Dev, 23: 1195-1206 (2009).
estelle.duprez@inserm.fr
French nationality
1990- Maîtrise de Biochimie. Paris VI. Mention assez bien
1991- D.E.A. d'Endocrinologie et interactions cellulaires. Paris XI. Mention bien.
2008-HDR de Aix-Marseille Université
1992-1995 PhD fellow, Unité INSERM U-301 Hôpital St Louis, PARIS.
Financial support: Bourse MRT, Bourse ARC.
1996-1997 Postdoctoral fellow Paul Freemont Lab Imperial Cancer Research Fund, LondonFinancial support: Bourse individuelle "Capital Humain et Mobilité" de la CE.
1999-2002-Détachement, Division of Hematology/ Oncology Harvard Institute of Medicine, Boston, USA, Dan Tenen Lab.
Publications
Publications
3014 – ORAL PRESENTATION: SINGLE-CELL RNA-SEQ REVEALS A CONCOMITANT DELAY IN DIFFERENTIATION AND CELL CYCLE OF AGED HEMATOPOIETIC STEM CELLISEH, Aug 2020, New york, United States. pp.S42, ⟨10.1016/j.exphem.2020.09.035⟩ |
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New Insights into PLZF/Rara Mechanism during APL Onset: EZH2 on the Road61st Annual Meeting and Exposition of the American-Society-of-Hematology (ASH), Oct 2019, Orlando, United States. pp.3761-3761, ⟨10.1182/blood-2019-125509⟩ |
Deciphering EZH2 Non-Canonical Activities in AML ResistanceThe 66th ASH Annual Meeting, Dec 2024, San Diego (CA), United States. 144 (Supplement 1), pp.4097-4097, 2024, ⟨10.1182/blood-2024-200580⟩ |
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H1.3 depletion in AML cells prompts H1.2 redistribution, chromatin remodeling and cell cycle defects2025 |
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Single-cell multi-omics analyses reveal EZH2 as a main driver of retinoic acid resistance in PLZF-RARA leukemia2022 |