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Emmanuel GUEDON

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Comparison of partial least square, artificial neural network, and support vector regressions for real‐time monitoring of CHO cell culture processes using in situ near‐infrared spectroscopy

Daniel Zavala-Ortiz , Aurélia Denner , Maria Aguilar-Uscanga , Annie Marc , Bruno Ebel et al.
Biotechnology and Bioengineering, 2022, 119 (2), pp.535-549. ⟨10.1002/bit.27997⟩
Journal articles hal-03844328v1

A new perfusion mode of culture for WJ‐MSCs expansion in a stirred and online monitored bioreactor

Caroline Sion , Dima Ghannoum , Bruno Ebel , Fanny Gallo , Natalia Isla et al.
Biotechnology and Bioengineering, 2021, 118 (11), pp.4453-4464. ⟨10.1002/bit.27914⟩
Journal articles hal-03505287v1
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Fermentation of cellulose pyrolysis oil by a Clostridial bacterium

Buendia-Kandia Felipe , Charles Greenhalf , Chiara Barbiero , E. Guédon , Cedric Briens et al.
Biomass and Bioenergy, 2020, 143, pp.105884. ⟨10.1016/j.biombioe.2020.105884⟩
Journal articles hal-03094948v1

Corynebacterium glutamicum , a natural overproducer of succinic acid?

Amani Briki , Karim Kaboré , Eric Olmos , Sabine Bosselaar , Fabrice Blanchard et al.
Engineering in Life Sciences, 2020, 20 (5-6), pp.205-215. ⟨10.1002/elsc.201900141⟩
Journal articles hal-02968827v1
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Interest of locally weighted regression to overcome nonlinear effects during in situ NIR monitoring of CHO cell culture parameters and antibody glycosylation

Daniel Zavala‐ortiz , Bruno Ebel , Meng‐yao Li , Dulce Ma. Barradas‐dermitz , Patricia Hayward‐jones et al.
Biotechnology Progress, 2020, 36 (e2924), pp.1-10. ⟨10.1002/btpr.2924⟩
Journal articles hal-02333228v1
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In situ cell differentiation monitoring of Catharanthus roseus suspension culture processes by NIR spectroscopy

Daniel Zavala-Ortiz , Bruno Ebel , Emmanuel Guedon , Annie Marc , Dulce Barradas-Dermitz et al.
Bioprocess and Biosystems Engineering, 2020, 43, pp.747-752. ⟨10.1007/s00449-019-02255-x⟩
Journal articles hal-02366817v1
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Support Vector and Locally Weighted regressions to monitor monoclonal antibody glycosylation during CHO cell culture processes, an enhanced alternative to Partial Least Squares regression

Daniel Zavala-Ortiz , Bruno Ebel , Mengyao Li , Dulce Ma. Barradas‐dermitz , Patricia Hayward-Jones et al.
Biochemical Engineering Journal, 2020, 154, pp.107457. ⟨10.1016/j.bej.2019.107457⟩
Journal articles hal-02376535v1

Effects of microcarriers addition and mixing on WJ-MSC culture in bioreactors

C. Sion , C. Loubière , M.K. Wlodarczyk-Biegun , N. Davoudi , C. Müller-Renno et al.
Biochemical Engineering Journal, 2020, 157, pp.107521. ⟨10.1016/j.bej.2020.107521⟩
Journal articles hal-02968768v1
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Dimensional analysis and CFD simulations of microcarrier ‘just-suspended’ state in mesenchymal stromal cells bioreactors

Angélique Delafosse , Céline Loubière , Emmanuel Guedon , I. Chevalot , Dominique Toye et al.
Chemical Engineering Science, 2019, 203, pp.464-474. ⟨10.1016/j.ces.2019.04.001⟩
Journal articles hal-02151663v1
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Control of IgG glycosylation by in situ and real-time estimation of specific growth rate of CHO cells cultured in bioreactor

Meng-Yao Li , Bruno Ebel , Fabrice Blanchard , Cedric Paris , Emmanuel Guedon et al.
Biotechnology and Bioengineering, 2019, 116, pp.985-993. ⟨10.1002/bit.26914⟩
Journal articles hal-01980640v1
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Impact of the type of microcarrier and agitation modes on the expansion performances of mesenchymal stem cells derived from umbilical cord

Céline Loubière , Caroline Sion , Natalia de Isla , Loïc Reppel , Emmanuel Guedon et al.
Biotechnology Progress, 2019, 35 (6), pp.e2887. ⟨10.1002/btpr.2887⟩
Journal articles hal-02968491v1

Hydrothermal conversion of wood, organosolv and chlorite pulps

Felipe Buendia-Kandia , Nicolas Brosse , Dominique Petitjean , Guillain Mauviel , Emmanuel Rondags et al.
Biomass Conversion and Biorefinery, 2019, 10 (1), pp.1. ⟨10.1007/s13399-019-00395-4⟩
Journal articles hal-02125963v1

Optimization of the Impeller Design for Mesenchymal Stem Cell Culture on Microcarriers in Bioreactors

Céline Loubière , Angélique Delafosse , Emmanuel Guedon , Dominique Toye , Isabelle Chevalot et al.
Chemical Engineering and Technology, 2019, 42 (8), pp.1702-1708. ⟨10.1002/ceat.201900105⟩
Journal articles hal-02151665v1

Diauxic growth of Clostridium acetobutylicum ATCC 824 when grown on mixtures of glucose and cellobiose

Felipe Buendia-Kandia , Emmanuel Rondags , Xavier Framboisier , Guillain Mauviel , Anthony Dufour et al.
AMB Express, 2018, 8 (1), pp.9. ⟨10.1186/s13568-018-0615-2⟩
Journal articles hal-01797977v1
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Light-sensitive dextran-covered PNBA nanoparticles as triggered drug delivery systems: Formulation, characteristics and cytotoxicity

Meriem El Founi , Soliman Mehawed Abdellatif Soliman , Régis Vanderesse , Samir Acherar , Emmanuel Guedon et al.
Journal of Colloid and Interface Science, 2018, 514, pp.289 - 298. ⟨10.1016/j.jcis.2017.12.036⟩
Journal articles hal-01924074v1

Parallel comparison of in situ Raman and NIR spectroscopies to simultaneously measure multiple variables toward real-time monitoring of CHO cell bioreactor cultures

Mengyao Li , Bruno Ebel , Fabien Chauchard , Emmanuel Guedon , Annie Marc et al.
Biochemical Engineering Journal, 2018, 137, pp.205 - 213. ⟨10.1016/j.bej.2018.06.005⟩
Journal articles hal-01921094v1

Real-time monitoring of antibody glycosylation site occupancy by in situ Raman spectroscopy during bioreactor CHO cell cultures

Meng-Yao Li , Bruno Ebel , Cédric Paris , Fabien Chauchard , Emmanuel Guedon et al.
Biotechnology Progress, 2018, 34 (2), pp.486 - 493. ⟨10.1002/btpr.2604⟩
Journal articles hal-01921118v1
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Study and modeling of fluctuating dissolved oxygen concentration impact on Corynebacterium glutamicum growth in a scale-down bioreactor

Abdoul Karim Kaboré , Stéphane Delaunay , Fabrice Blanchard , Emmanuel Guedon , Michel Fick et al.
Process Biochemistry, 2018, ⟨10.1016/j.procbio.2018.10.016⟩
Journal articles hal-01924081v1

Revisiting MSC expansion from critical quality attributes to critical culture process parameters

Céline Martin , Eric Olmos , Marie-Laure Collignon , Natalia de Isla , Fabrice Blanchard et al.
Process Biochemistry, 2017, 59, pp.231 - 243. ⟨10.1016/j.procbio.2016.04.017⟩
Journal articles hal-01921144v1

Decomposition of cellulose in hot-compressed water: detailed analysis of the products and effect of operating conditions

Felipe Buendia-Kandia , Guillain Mauviel , Emmanuel Guedon , Emmanuel Rondags , Dominique Petitjean et al.
Journal articles hal-01651273v1

Foreword Advances in “Stem Cell Bioengineering”

Emmanuel Guedon
Process Biochemistry, 2017, 59, pp.229 - 230. ⟨10.1016/j.procbio.2017.07.023⟩
Journal articles hal-01924087v1

Aerobiosis–anaerobiosis transition has a significant impact on organic acid production by Corynebacterium glutamicum

Abdoul-Karim Kaboré , Eric Olmos , Michel Fick , Fabrice Blanchard , Emmanuel Guedon et al.
Process Biochemistry, 2017, 52, pp.10 - 21. ⟨10.1016/j.procbio.2016.10.007⟩
Journal articles hal-01924060v1

3D in vitro co-culture models based on normal cells and tumor spheroids formed by cyclic RGD-peptide induced cell self-assembly

Roman Akasov , Anastasia Gileva , Daria Zaytseva-Zotova , Sergey Burov , Isabelle Chevalot et al.
Biotechnology Letters, 2017, 39 (1), pp.45 - 53. ⟨10.1007/s10529-016-2218-9⟩
Journal articles hal-01921238v1

A dual near-infrared and dielectric spectroscopies strategy to monitor populations of Chinese hamster ovary cells in bioreactor

Franck Courtès , Bruno Ebel , Emmanuel Guedon , Annie Marc
Biotechnology Letters, 2016, 38 (5), pp.745 - 750. ⟨10.1007/s10529-016-2036-0⟩
Journal articles hal-01921187v1

Liposomal nanodelivery systems using soy and marine lecithin to encapsulate food biopreservative nisin

Muhammad Imran , Anne-Marie Revol-Junelles , Cedric Paris , Emmanuel Guedon , Michel Linder et al.
LWT - Food Science and Technology, 2015, 62 (1, 1), pp.341-349. ⟨10.1016/j.lwt.2014.12.046⟩
Journal articles hal-01267001v1

Impact of gas-liquid mass transfer on organic acids production by Corynebacterium glutamicum in unbaffled shake flasks

Abdoul Karim Kabore , Eric Olmos , Fabrice Blanchard , Michel Fick , Stéphane Delaunay et al.
Biochemical Engineering Journal, 2015, 101, pp.237-247. ⟨10.1016/j.bej.2015.06.003⟩
Journal articles hal-01266260v1

Lactate production as representative of the fermentation potential of Corynebacterium glutamicum 2262 in a one-step process

Hoang Bao Truc Khuat , Abdoul Karim Kabore , Eric Olmos , Michel Fick , Joseph Boudrant et al.
Bioscience, Biotechnology and Biochemistry, 2014, 78 (2), pp.343-349. ⟨10.1080/09168451.2014.878219⟩
Journal articles hal-01276064v1

Towards a Tissue-Engineered Ligament: Design and Preliminary Evaluation of a Dedicated Multi-Chamber Tension-Torsion Bioreactor

Cédric Laurent , Cédryck Vaquette , Céline Martin , Emmanuel Guedon , Xiude Wu et al.
Processes, 2014, 2 (1), pp.167. ⟨10.3390/pr2010167⟩
Journal articles hal-01424974v1

Investigation of Growth Conditions for the Expansion of Porcine Mesenchymal Stem Cells on Microcarriers in Stirred Cultures

Caroline Ferrari , Eric Olmos , Frederique Balandras , Nguyen Tran , Isabelle Chevalot et al.
Applied Biochemistry and Biotechnology, 2014, 172 (2), pp.1004-1017. ⟨10.1007/s12010-013-0586-3⟩
Journal articles hal-01276641v1

Biodegradation of Phenanthrene by Pseudomonas putida and a Bacterial Consortium in the Presence and in the Absence of a Surfactant

Tatiana Pantsyrnaya , Stéphane Delaunay , Jean-Louis Goergen , Emmanuel Guedon , Cedric Paris et al.
Indian Journal of Microbiology, 2012, 52 (3), pp.420-426. ⟨10.1007/s12088-012-0265-z⟩
Journal articles hal-00777647v1

Limiting Cell Aggregation During Mesenchymal Stem Cell Expansion on Microcarriers

Caroline Ferrari , Frederique Balandras , Emmanuel Guedon , Eric Olmos , Isabelle Chevalot et al.
Biotechnology Progress, 2012, 28 (3), pp.780-787. ⟨10.1002/btpr.1527⟩
Journal articles hal-00777492v1

Effect of surfactants, dispersion and temperature on solubility and biodegradation of phenanthrene in aqueous media.

T. Pantsyrnaya , Fabian Blanchard , S. Delaunay , J.L. Goergen , E. Guedon et al.
Chemosphere, 2011, 83 ((1)), pp. 29-33. ⟨10.1016/j.chemosphere.2011.01.024⟩
Journal articles hal-00604685v1

Effect of surfactants, dispersion and temperature on solubility and biodegradation of phenanthrene in aqueous media

T. Pantsyrnaya , Fabian Blanchard , S. Delaunay , J.L. Goergen , E. Guédon et al.
Chemosphere, 2011, 83 (1), pp.29-33. ⟨10.1016/j.chemosphere.2011.01.024⟩
Journal articles hal-03060481v1

Effect of surfactant pluronic F-68 on CHO cell growth, metabolism, production, and glycosylation of human recombinant IFN-γ in mild operating conditions

M.F. Clincke , E. Guedon , F.T. Yen , V. Ogier , O. Roitel et al.
Biotechnology Progress, 2011, 27 ((1)), pp. 181-190. ⟨10.1002/btpr.503⟩
Journal articles hal-00606341v1
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Biotransformation of Naringenin to Eriodictyol by Saccharomyces cerevisiea Functionally Expressing Flavonoid 3 ' Hydroxylase

Ilef Limen Ben Amor , Alain Hehn , Emmanuel Guedon , Kamel Ghedira , Jean-Marc Engasser et al.
Natural Product Communications , 2010, 5 (12), pp.1893-1898. ⟨10.1177/1934578X1000501211⟩
Journal articles hal-00799067v1
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Preliminary investigation of naringenin hydroxylation with recombinant E. coli expressing plant flavonoid hydroxylation gene

Ilef Limen Ben Amor , Nidhal Salem , Emmanuel Guedon , Jean-Marc Engasser , Leila Chekir-Ghedira et al.
Natural Product Communications , 2010, 5 (5), pp.777-782. ⟨10.1177/1934578X1000500520⟩
Journal articles hal-00799073v1

Kinetic characterization of vero cell metabolism in a serum-free batch culture process

E. Petiot , E. Guedon , Fabian Blanchard , C. Gény , H. Pinton et al.
Biotechnology and Bioengineering, 2010, 107 ((1)), pp. 143-153. ⟨10.1002/bit.22783⟩
Journal articles hal-00611352v1

OdhI dephosphorylation kinetics during different glutamate production processes involving Corynebacterium glutamicum

Kenza-Amel Boulahya, , Emmanuel Guedon , Stéphane Delaunay , Christian Schultz , Joseph Boudrant et al.
European Journal of Applied Microbiology and Biotechnology, 2010, 87 (5), pp.1867-1874. ⟨10.1007/s00253-010-2599-y⟩
Journal articles hal-00799151v1

Investigation of biological activity of polar extracts isolated from Phlomis crinita Cav ssp. mauritanica Munby

I. Limem , I. Skandrani , J. Boubaker , M. Ben Sgaier , A. Neffati et al.
Drug and Chemical Toxicology, 2009, 32 (1), pp.38-46
Journal articles hal-00508044v1

Influence of intracellular nucleotide and nucleotide sugar contents on recombinant interferon-gamma; glycosylation during batch and fed-batch cultures of CHO cells

N. Kochanowski , Fabian Blanchard , R. Cacan , F. Chirat , A. Marc et al.
Biotechnology and Bioengineering, 2008, 100 (4), pp.721-733. ⟨10.1002/bit.21816⟩
Journal articles hal-00379732v1

Production of phenylpropanoid compounds by recombinant microorganisms expressing plant-specific biosynthesis genes

I. Limem , E. Guedon , A. Hehn , F. Bourgaud , L. Chekir Ghedira et al.
Process Biochemistry, 2008, 43 (5), pp.463-479. ⟨10.1016/j.procbio.2008.02.001⟩
Journal articles hal-00379981v1

Décontamination de sols pollués par les hydrocarbures aromatiques polycycliques par biodégradation en présence de substrats organiques supplémentaires

N. Simeon , G. Mercier , J.F. Blais , Stéphanie Ouvrard , A. Cebron et al.
Revue du Génie et de la Science de l'Environnement, 2008, 7 (5), pp.467-479. ⟨10.1139/S08-027⟩
Journal articles hal-00380365v1

Mathematical modeling of L-glutamic acid production

T. Nizhegorodova , E. Guseva , N. Menshutina , J. Boudrant , J.L. Goergen et al.
Izvestiya Vuzov. Seria Himiya i himicheskaya tehnologiya, 2007, 50, pp.93-98
Journal articles hal-00278429v1

Cell envelope fluidity modification for an affective glutamate excretion in Corynebacterium glutamicum 2262

D. Bokas , D. Uy , F. Grattepanche , G. Duportail , E. Guedon et al.
Applied Microbiology and Biotechnology, 2007, 76, pp.773-781
Journal articles hal-00171988v1

Cell envelope fluidity modification for an effective glutamate excretion in Corynebacterium glutamicum 2262

D. Bokas , D. Uy , F. Grattepanche , G. Duportail , Emmanuel Guedon et al.
Applied Microbiology and Biotechnology, 2007, 76 (4), pp.773-781. ⟨10.1007/s00253-007-1046-1⟩
Journal articles hal-00277816v1

Intracellular nucleotide and nucleotide sugar contents of cultured CHO cells determined by a fast, sensitive, and high-resolution ion-pair RP-HPLC

N. Kochanowski , Fabian Blanchard , R. Cacan , F. Chirat , E. Guedon et al.
Analytical Biochemistry, 2006, 348 (2), pp.243-251. ⟨10.1016/j.ab.2005.10.027⟩
Journal articles hal-00077315v1
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Improvement of Cellulolytic Properties of Clostridium cellulolyticum by Metabolic Engineering

Emmanuel Guedon , Mickael M. Desvaux , Henri Petitdemange
Applied and Environmental Microbiology, 2002, 68 (1), pp.53 - 58. ⟨10.1128/AEM.68.1.53-58.2002⟩
Journal articles hal-02910792v1
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Carbon Flux Distribution and Kinetics of Cellulose Fermentation in Steady-State Continuous Cultures of Clostridium cellulolyticum on a Chemically Defined Medium

Mickael M. Desvaux , Emmanuel Guedon , Henri Petitdemange
Journal of Bacteriology, 2001, 183 (1), pp.119-130. ⟨10.1128/JB.183.1.119-130.2001⟩
Journal articles hal-02910799v1

Both pH and carbon flux influence the level of rubredoxin in Clostridium butyricum

Emmanuel Guedon , Philippe Gerard , Bruno Charpentier , Christiane Branlant , Henri Petitdemange et al.
Current Microbiology, 2001, 43 (6), pp.434-439. ⟨10.1007/s002840010334⟩
Journal articles hal-01600080v1

Réseau de régulation de la transcription des gènes du système protéolytique de Lactococcus lactis

E. Guedon , C. Martin , F.X. Gobert , S.D. Ehrlich , P. Renault et al.
Lait, 2001, 81 (1-2), pp.65-74
Journal articles hal-02674703v1
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Kinetics and Metabolism of Cellulose Degradation at High Substrate Concentrations in Steady-State Continuous Cultures of Clostridium cellulolyticum on a Chemically Defined Medium

Mickael M. Desvaux , Emmanuel Guedon , Henri Petitdemange
Applied and Environmental Microbiology, 2001, 67 (9), pp.3837 - 3845. ⟨10.1128/AEM.67.9.3837-3845.2001⟩
Journal articles hal-02910803v1
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Metabolic flux in cellulose batch and cellulose-fed continuous cultures of Clostridium cellulolyticum in response to acidic environment

Mickael M. Desvaux , Emmanuel Guedon , Henri Petitdemange
Microbiology, 2001, 147 (6), pp.1461-1471. ⟨10.1099/00221287-147-6-1461⟩
Journal articles hal-02910800v1

Relationships Between Cellobiose Catabolism, Enzyme Levels, and Metabolic Intermediates in Clostridium cellulolyticum Grown in a Synthetic Medium

Emmanuel Guedon , Sophie Payot , M Desvaux , H. Petitdemange
Inc. Biotechnol Bioeng, 2000, 67, pp.327 - 335
Journal articles hal-02910822v1
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Cellulose Catabolism by Clostridium cellulolyticum Growing in Batch Culture on Defined Medium Downloaded from

Mickael M. Desvaux , Emmanuel Guedon , Henri Petitdemange
Applied and Environmental Microbiology, 2000, 66 (6), pp.2461 - 2470. ⟨10.1128/AEM.66.6.2461-2470.2000⟩
Journal articles hal-02910808v1
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Kinetic Analysis of Clostridium cellulolyticum Carbohydrate Metabolism: Importance of Glucose 1-Phosphate and Glucose 6-Phosphate Branch Points for Distribution of Carbon Fluxes Inside and Outside Cells as Revealed by Steady-State Continuous Culture

Emmanuel Guedon , Mickael M. Desvaux , Henri Petitdemange
Journal of Bacteriology, 2000, 182 (7), pp.2010-2017. ⟨10.1128/JB.182.7.2010-2017.2000⟩
Journal articles hal-02910812v1

Evaluation de la diversité de l'expression génétique chez les lactocoques : développement d'un outil et son application aux peptidases

E. Guedon , P. Renault , S.D. Ehrlich , Christine C. Delorme
Sciences des aliments = Food science : an international journal of food science and technology, 2000, 20 (1), pp.55-62
Journal articles hal-02684710v1

The Extracellular Xylan Degradative System in Clostridium cellulolyticum Cultivated on Xylan: Evidence for Cell-Free Cellulosome Production

O. Mohand-Oussaid , Sophie Payot , E. Guedon , Éric Gelhaye , A. Youyou et al.
Journal of Bacteriology, 1999, 181 (13)
Journal articles hal-01787581v1

Growth inhibition of Clostridium cellulolyticum by an inefficiently regulated carbon flow

E. Guedon , Mickael M. Desvaux , Sophie Payot , H. Petitdemange
Microbiology, 1999, 145 (8), pp.1831 - 1838. ⟨10.1099/13500872-145-8-1831⟩
Journal articles hal-01787598v1

Induction of lactate production associated with a decrease in NADH cell content enables growth resumption of Clostridium cellulolyticum in batch cultures on cellobiose

Sophie Payot , Emmanuel Guedon , Éric Gelhaye , Henri Petitdemange
Research in Microbiology, 1999, 150 (7), pp.465 - 473. ⟨10.1016/S0923-2508(99)00110-2⟩
Journal articles hal-01787587v1

Effect of dilution rate, cellobiose and ammonium availabilities on Clostridium cellulolyticum sporulation

Sophie Payot , Emmanuel Guedon , Mickael M. Desvaux , Éric Gelhaye , E. Petitdemange et al.
Applied Microbiology and Biotechnology, 1999, 52 (5), pp.670-674. ⟨10.1007/s002530051577⟩
Journal articles hal-02910824v1

Carbon and Electron Flow in Clostridium cellulolyticum Grown in Chemostat Culture on Synthetic Medium Downloaded from

Emmanuel Guedon , Sophie Payot , Mickael M. Desvaux , H. Petitdemange
Journal of Bacteriology, 1999, 181 (10), pp.3262 - 3269. ⟨10.1128/JB.181.10.3262-3269.1999⟩
Journal articles hal-02910828v1

Du génome à l'application

P. Renault , S. Calero , Christine C. Delorme , S. Drouault , N. Goupil-Feuillerat et al.
Lait, 1998, 78, pp.39-52
Journal articles hal-02684934v1

Metabolism of cellobiose by Clostridium cellulolyticum growing in continuous culture: evidence for decreased NADH reoxidation as a factor limiting growth

Sophie Payot , E. Guedon , C. Cailliez , Éric Gelhaye , H. Petitdemange et al.
Microbiology, 1998, 144 (2), pp.375 - 384. ⟨10.1099/00221287-144-2-375⟩
Journal articles hal-01787609v1

Chemometrics to monitor CHO cell cultures quality by in situ NIRS

Daniel Zavala-Ortiz , Mengyao Li , Maria Aguilar-Uscanga , Javier Gomez-Rodrigues , Dulce Barradas-Dermitz et al.
26th ESACT meeting " Cell culture technologies: bridging academia and industry to provide solutions for patients", BMC Proceedings, May 2019, Copenhague, Denmark
Conference papers hal-02333483v1

Enhanced method to monitor cell cultures by dielectric spectroscopy

Daniel Zavala-Ortiz , Mengyao Li , Maria Aguilar-Uscanga , Javier Gomez-Rodrigues , Dulce Barradas-Dermitz et al.
26th ESACT meeting " Cell culture technologies: bridging academia and industry to provide solutions for patients", BMC Proceedings, May 2019, Copenhague, Denmark
Conference papers hal-02333492v1

In situ Raman spectroscopy as a promising PAT tool for monitoring of macro and micro-heterogeneity of monoclonal antibody glycosylation produced by CHO cells in bioreactors

Mengyao Li , Bruno Ebel , Cédric Paris , Fabien Chauchard , Emmanuel Guedon et al.
5th BioProScale Symposium: Innovative scale up and scale down for bioprocess intensification, Mar 2018, Berlin, Germany
Conference papers hal-02333510v1

In situ Raman spectroscopy monitoring of macro and micro-heterogeneity of monoclonal antibody glycosylation produced by CHO cells in bioreactors

Mengyao Li , Bruno Ebel , Cédric Paris , Fabien Chauchard , Emmanuel Guedon et al.
5th BioProScale Symposium: Innovative scale up and scale down for bioprocess intensification, Mar 2018, Berlin, Germany
Conference papers hal-01922509v1

Real-time analysis of antibody glycosylation using in-line Raman spectroscopy in cell culture

Mengyao Li , Bruno Ebel , Cédric Paris , Fabien Chauchard , Emmanuel Guedon et al.
3rd Conference on Process Optimization and Safety in Industry 4.0, Sep 2018, Paris, France
Conference papers hal-01922497v1

Nanoparticules à coeur poly(acrylate d'o-nitrobenzyle) et couronne polysaccharide : vers un traitement anticancéreux photo-activable

Meriem El Founi , Soliman Mehawed Abdellatif Soliman , Emmanuel Guedon , Isabelle Chevalot , Vanderesse Régis et al.
GFP 2017, Nov 2017, Paris, France
Conference papers hal-03239706v1

Online and real-time control of CHO cell specific growth rate throughout cultures in bioreactor

Mengyao Li , Bruno Ebel , Frantz Fournier , Emmanuel Guedon , Annie Marc et al.
25th ESACT meeting "Cell technologies for innovative therapies", BMC Proceedings 2017, 12 (Suppl 1):3-P134, May 2017, Lausanne, Switzerland
Conference papers hal-01922275v1

PNBA-based photosensitive nanoparticles: a novel devices for controlled drug delivery

Meriem El Founi , Soliman Mehawed Abdellatif Soliman , Régis Vanderesse , Samir Acherar , Emmanuel Guedon et al.
91st ACS Colloid and Surface Science Symposium, Jul 2017, New York, United States
Conference papers hal-03239576v1

Systèmes nanoparticulaires d'administration de médicaments à base de poly(acrylate d'o-nitrobenzyle) et à libération photodéclenchée

Meriem El Founi , Soliman Mehawed Abdellatif Soliman , Emmanuel Guedon , Isabelle Chevalot , Vanderesse Régis et al.
15e Journée Scientifique du GFP section Grand-Est, Jun 2017, strasbourg, France
Conference papers hal-03239657v1

Real-time monitoring of the physiological state of CHO cells in bioreactor by using a dual spectroscopic strategy

Franck Courtès , Bruno Ebel , Emmanuel Guedon , Annie Marc
24th European Society for Animal Cell Technology (ESACT) Meeting: C2P2: Cells, Culture, Patients, Products, May 2015, Barcelone, Spain. ⟨10.1186/1753-6561-9-S9-P48⟩
Conference papers hal-01305628v1

Serum-free media for mesenchymal stem cells expansion on microcarriers

Céline Martin , Alexandre Piccini , Isabelle Chevalot , Eric Olmos , Emmanuel Guedon et al.
24th European Society for Animal Cell Technology (ESACT) Meeting: C2P2: Cells, Culture, Patients, Products, May 2015, Barcelone, Spain. ⟨10.1186/1753-6561-9-S9-P70⟩
Conference papers hal-01305688v1

Recent advances in the study of the hydrodynamics of bioreactors used for the culture of living cells

Éric Olmos , Abdoul Karim Kabore , Céline Martin , Marie-Laure Collignon , Isabelle Chevalot et al.
9th international symposium on CAtalysis in MUltiphase Reactors, Dec 2014, Lyon, France
Conference papers hal-01922581v1

Stress during cell culture processes

J. Boudrant , N. Barbouche , N. Mehmood , E. Olmos , S. Delaunay et al.
13th International Biotechnology Symposium and Exhibition, Biotechnology for the Sustainability of Human Society, Oct 2008, DALIAN, China
Conference papers hal-00401153v1

Contraintes hydrodynamiques et culture de cellules animales en réacteur : quel rôle pour le copolymère Pluronic-68 ?

N. Barbouche , E. Guedon , A. Marc , E. Olmos
Colloque de la fédération Gay-Lussac "La chimie du et pour le vivant", Dec 2008, RENNES, France
Conference papers hal-00401130v1

Réseau de régulation de la transcription des gènes du système protéolytique de Lactococcus lactis

E. Guedon , C. Martin , F.X. Gobert , S.D. Ehrlich , P. Renault et al.
10. Colloque du Club des Bactéries Lactiques, Apr 2000, Strasbourg, France
Conference papers hal-02825666v1

Etude de l'adaptation de Lactococcus lactis a l'environnement digestif : approche génétique

Gerard Corthier , Sophie Gilbert , M.C. Muller , Christine C. Delorme , S. Drouault et al.
Rencontres des Microbiologistes de l'INRA, Apr 1999, Dourdan, France
Conference papers hal-02771131v1

Evaluation de la diversité de l'expression génétique chez les lactocoques : développement d'un outil et son application aux peptidases

E. Guedon , P. Renault , S.D. Ehrlich , Christine C. Delorme
9. Colloque du Club des Bactéries Lactiques, Oct 1998, Bourg-en-Bresse, France
Conference papers hal-02835362v1

Suivi en-ligne de la qualité d’anticorps produits par cellules CHO par spectrométrie NIR in situ couplée à une régression à vecteurs de support

Daniel Zavala-Ortiz , Bruno Ebel , Mengyao Li , Maria Aguilar-Uscanga , Javier Gomez-Rodrigues et al.
17ème Congrès de la Société Française de Génie des Procédés, Oct 2019, Nantes, France
Conference poster hal-02333525v1

Interest of cell heterogeneity for the production of anticancer drugs vincristine and vinblastine by suspension cultures of Catharanthus roseus

Daniel Zavala-Ortiz , Dulce Barradas-Dermitz , Bruno Ebel , Emmanuel Guedon , Annie Marc et al.
40th National Meeting of the AMIDIQ, "Challenges of chemical engineering for national development", May 2019, Hualtuco, Mexico
Conference poster hal-02333533v1

Amélioration du suivi en temps réel de l’état physiologique de cellules CHO par spectroscopie diélectrique in situ et régression à vecteurs de support

Daniel Zavala-Ortiz , Bruno Ebel , Mengyao Li , Maria Aguilar-Uscanga , Javier Gomez-Rodrigues et al.
17ème Congrès de la Société Française de Génie des Procédés, Oct 2019, Nantes, France
Conference poster hal-02333522v1

Interest of NIR spectroscopy to perform rapid analysis of medium compounds of Taxus globosa plant cells cultivated in suspension

Daniel Zavala-Ortiz , Bruno Ebel , Mengyao Li , Dulce Barradas-Dermitz , Maria Aguilar-Uscanga et al.
12th European Symposium on Biochemical Engineering Sciences, Sep 2018, Lisbonne, Portugal
Conference poster hal-01922399v1

Interest of the Locally Weighted Regression to improve real-time monitoring of CHO and antibody quality by using in situ NIR spectroscopy

Daniel Zavala-Ortiz , Bruno Ebel , Emmanuel Guedon , Annie Marc , Dulce Barradas-Dermitz et al.
12th European Symposium on Biochemical Engineering Sciences, Sep 2018, Lisbonne, Portugal
Conference poster hal-01922411v1

Improvement of the production process of Taxus globosa S. cells by cellular synchronization for the subsequent production of the anti-cancer paclitaxel

Daniel Zavala-Ortiz , Dulce Barradas-Dermitz , Bruno Ebel , Emmanuel Guedon , Annie Marc et al.
Congrès de l'AMIDIQ (Academia Mexicana de Investigation y Docencia en Ingeniera Quimica), San José des Cabo, Mexique, 1 - 4 mai 2018, May 2018, San José des Cabo, Mexico
Conference poster hal-01922390v1

Intérêt de l'estimation en temps réel de la vitesse spécifique de croissance pour le pilotage de cultures de cellules animales

Mengyao Li , Bruno Ebel , Frantz Fournier , Emmanuel Guedon , Annie Marc et al.
16ème Congrès de la Société Française de Génie des Procédés, Jul 2017, Nancy, France
Conference poster hal-01922378v1

Ethanol production monitoring during Pichia Stipitis yeasts fermentation using on-line near-infrared spectroscopy

Victor Corro , Patricia Hayward-Jones , Dulce Barradas-Dermitz , Anne Gschaedler , Bruno Ebel et al.
3rd European Congress of Applied Biotechnology, Oct 2015, Nice, France
Conference poster hal-01922340v1

Utilisation combinée de techniques spectroscopiques pour le suivi en ligne de l'état physiologique de cellules CHO cultivées en bioréacteur

Franck Courtès , Bruno Ebel , Emmanuel Guedon , Annie Marc
21èmes journées du Groupe Français de Spectroscopies Vibrationnelles, Jun 2015, Reims, France
Conference poster hal-01922324v1

In situ infrared spectroscopy as a PAT tool of great promise for real-time monitoring of animal cell culture processes

Mengyao Li , Bruno Ebel , Franck Courtès , Emmanuel Guedon , Annie Marc et al.
Journal of Analytical and Pharmaceutical Chemistry, 3, 2, 1065-70, 2016
Book sections hal-01922462v1

Anaerobie production of organie acids and alcohols with Corynebacterium glutamicum

Stéphane Delaunay , Abdoul Karim Kabore , Mickael Cregut , Huang Bao Truc Khuat , Emmanuel Guedon et al.
Carlos Barreiro. New trends in Corynebacterium glutamicum: beyond the amino acids, Nova Sciences Pub, 2015, 978-1-63483-280-9
Book sections hal-01962320v1

Défis de la culture de cellules animales en bioréacteur

Annie Marc , Emmanuel Guedon , Eric Olmos , Fabrice Blanchard , Isabelle Chevalot et al.
Culture de cellules animales, 3ème édition (eds. G. Barlovatz-Meimon, X. Ronot), pp. 61-70. Tec&Doc, Lavoisier, Paris, 2014
Book sections hal-01922265v1

Procédés biotechnologiques pour la production de protéines recombinantes à usage thérapeutiques : vers une maîtrise de la glycosylation

M.F. Clincke , Emmanuel Guedon , Jean-Louis Goergen
Traité Bioprocédés, Techniques de l'Ingénieur, BIO 6 200 p. 1-19, 2011
Book sections hal-00822941v1