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Etienne Lefai

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SREBP-1 upregulates lipophagy to maintain cholesterol homeostasis in brain tumor cells

Feng Geng , Yaogang Zhong , Huali Su , Etienne Lefai , Shino Magaki
Cell Reports, 2023, 42 (7), pp.112790. ⟨10.1016/j.celrep.2023.112790⟩
Journal articles hal-04279038v1
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Induction of ATF4-Regulated Atrogenes Is Uncoupled from Muscle Atrophy during Disuse in Halofuginone-Treated Mice and in Hibernating Brown Bears

Laura Cussonneau , Cécile Coudy-Gandilhon , Christiane Deval , Ghita Chaouki , Mehdi Djelloul-Mazouz
International Journal of Molecular Sciences, 2023, 24 (1), pp.621. ⟨10.3390/ijms24010621⟩
Journal articles hal-04178468v1
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ANGPTL4 is a potential driver of HCV-induced peripheral insulin resistance

Diana Gomes , Cyril Sobolewski , Stéphanie Conzelmann , Tifany Schaer , Etienne Lefai
Scientific Reports, 2023, 13 (1), pp.6767. ⟨10.1038/s41598-023-33728-5⟩
Journal articles hal-04176948v1

Differential bone remodeling mechanism in hindlimb unloaded and hibernating Daurian ground squirrels: a comparison between artificial and natural disuse within the same species

Xuli Gao , Siqi Wang , Siqi Shen , Shuyao Wang , Manjiang Xie
Journal of Comparative Physiology B, 2023, 193 (3), pp.329-350. ⟨10.1007/s00360-023-01482-9⟩
Journal articles hal-04288563v1

Integrated transcriptomics and metabolomics reveal protective effects on heart of hibernating Daurian ground squirrels

Yingyu Yang , Ziwei Hao , Ning An , Yuting Han , Weilan Miao
Journal of Cellular Physiology, 2023, ⟨10.1002/jcp.31123⟩
Journal articles hal-04279721v1
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The Protective Effects on Ischemia–Reperfusion Injury Mechanisms of the Thoracic Aorta in Daurian Ground Squirrels (Spermophilus dauricus) over the Torpor–Arousal Cycle of Hibernation

Yuting Han , Weilan Miao , Ziwei Hao , Ning An , Yingyu Yang
International Journal of Molecular Sciences, 2022, 23 (18), pp.10248. ⟨10.3390/ijms231810248⟩
Journal articles hal-03842443v1
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Cardiomyocyte Protection by Hibernating Brown Bear Serum: Toward the Identification of New Protective Molecules Against Myocardial Infarction

Lucas Givre , Claire Crola da Silva , Jon E Swenson , Jon M Arnemo , Guillemette Gauquelin-Koch
Frontiers in Cardiovascular Medicine, 2021, 8, pp.687501. ⟨10.3389/fcvm.2021.687501⟩
Journal articles hal-03419383v1
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Ether lipids, sphingolipids and toxic 1-deoxyceramides as hallmarks for lean and obese type 2 diabetic patients

J. T. Hannich , U. Loizides-Mangold , F. Sinturel , T. Harayama , B. Vandereycken
Acta Physiologica, 2021, 232 (1), pp.e13610. ⟨10.1111/apha.13610⟩
Journal articles inserm-03269069v1
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Hibernating brown bears are protected against atherogenic dyslipidemia

Sylvain Giroud , Isabelle Chery , Mathilde Arrivé , Michel Prost , Julie Zumsteg
Scientific Reports, 2021, 11 (1), ⟨10.1038/s41598-021-98085-7⟩
Journal articles hal-03360652v1
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Concurrent BMP Signaling Maintenance and TGF-β Signaling Inhibition Is a Hallmark of Natural Resistance to Muscle Atrophy in the Hibernating Bear

Laura Cussonneau , Christian Boyer , Charlotte Brun , Christiane Deval , Emmanuelle Loizon
Cells, 2021, 10 (8), pp.1873. ⟨10.3390/cells10081873⟩
Journal articles hal-03314541v1
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MicroRNAs facilitate skeletal muscle maintenance and metabolic suppression in hibernating brown bears

Bryan E. Luu , Etienne Lefai , Sylvain Giroud , Jon E. Swenson , Blandine Chazarin
Journal of Cellular Physiology, 2020, 235 (4), pp.3984-3993. ⟨10.1002/jcp.29294⟩
Journal articles hal-02349938v1
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ANT2-Mediated ATP Import into Mitochondria Protects against Hypoxia Lethal Injury

Yves Gouriou , Muhammad Rizwan Alam , Zeina Harhous , Claire Crola da Silva , Delphine Baetz Baetz
Cells, 2020, 9 (12), pp.2542. ⟨10.3390/cells9122542⟩
Journal articles hal-03060378v1
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Specific shifts in the endocannabinoid system in hibernating brown bears

Christian Boyer , Laura Cussonneau , Charlotte Brun , Christiane Deval , Jean-Paul Pais de Barros
Frontiers in Zoology, 2020, 17, pp.35. ⟨10.1186/s12983-020-00380-y⟩
Journal articles hal-03054587v1
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Hypergravity as a gravitational therapy mitigates the effects of knee osteoarthritis on the musculoskeletal system in a murine model

Benoit Dechaumet , Damien Cleret , Marie-Thérèse Linossier , Arnaud Vanden-Bossche , Stéphanie Chanon
PLoS ONE, 2020, 15 (12), pp.e0243098. ⟨10.1371/journal.pone.0243098⟩
Journal articles hal-03152504v1
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A nutrient cocktail prevents lipid metabolism alterations induced by 20 days of daily steps reduction and fructose overfeeding: Result from a randomized study

Anthony Damiot , Rémi Demangel , John Noone , Isabelle Chery , Alexandre Zahariev
Journal of Applied Physiology, 2019, 126 (1), pp.88-101. ⟨10.1152/japplphysiol.00018.2018⟩
Journal articles hal-01918097v1
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Lipidomics Reveals Seasonal Shifts in a Large-Bodied Hibernator, the Brown Bear

Sylvain Giroud , Isabelle Chery , Fabrice Bertile , Justine Bertrand-Michel , Georg Tascher
Frontiers in Physiology, 2019, 10, ⟨10.3389/fphys.2019.00389⟩
Journal articles hal-02141629v1
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In-Depth Proteome Analysis Highlights HepaRG Cells as a Versatile Cell System Surrogate for Primary Human Hepatocytes

Georg Tascher , Audrey Burban , Sandrine Camus , Marine Plumel , Stéphanie Chanon
Cells, 2019, 8 (2), pp.E192. ⟨10.3390/cells8020192⟩
Journal articles hal-02050391v1
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Limited Oxidative Stress Favors Resistance to Skeletal Muscle Atrophy in Hibernating Brown Bears (Ursus Arctos)

Blandine Chazarin , Anna Ziemianin , Alina L. Evans , Emmanuelle Meugnier , Emmanuelle Loizon
Antioxidants , 2019, 8 (9), pp.334. ⟨10.3390/antiox8090334⟩
Journal articles hal-02274540v1
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Metabolic reprogramming involving glycolysis in the hibernating brown bear skeletal muscle

Blandine Chazarin , Kenneth B Storey , Anna Ziemianin , Stéphanie Chanon , Marine Plumel
Frontiers in Zoology, 2019, 16, pp.12. ⟨10.1186/s12983-019-0312-2⟩
Journal articles hal-02149735v1
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TRPV1 variants impair intracellular Ca2+ signaling and may confer susceptibility to malignant hyperthermia

Fabien Vanden Abeele , Sabine Lotteau , Sylvie Ducreux , Charlotte Dubois , Nicole Monnier
Genetics in Medicine, 2019, 21 (2), pp.441-450. ⟨10.1038/s41436-018-0066-9⟩
Journal articles hal-02475163v1
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Proteolysis inhibition by hibernating bear serum leads to increased protein content in human muscle cells

Stéphanie Chanon , Blandine Chazarin , Benoit Toubhans , Christine Durand , Isabelle Chery
Scientific Reports, 2018, 8 (1), pp.1-10. ⟨10.1038/s41598-018-23891-5⟩
Journal articles hal-01772255v1

Disruption of Mitochondria-Associated Endoplasmic Reticulum Membrane (MAM) Integrity Contributes to Muscle Insulin Resistance in Mice and Humans

Emily Tubbs , Stéphanie Chanon , Maud Robert , Nadia Bendridi , Gabriel Bidaux
Diabetes, 2018, 67 (4), pp.636-650. ⟨10.2337/db17-0316⟩
Journal articles hal-01847407v1

Seasonal changes in eicosanoid metabolism in the brown bear

Sylvain Giroud , Alina M Evans , Isabelle Chery , Fabrice Bertile , Georg Tascher
The Science of Nature Naturwissenschaften, 2018, 105 (9-10), ⟨10.1007/s00114-018-1583-8⟩
Journal articles hal-01907890v1

Metabolic inflexibility is an early marker of bed-rest–induced glucose intolerance even when fat mass is stable

Floriane Rudwill , Donal O’gorman , Etienne Lefai , Isabelle Chery , Alexandre Zahariev
Journal of Clinical Endocrinology and Metabolism, 2018, 103 (5), pp.1910-1920. ⟨10.1210/jc.2017-02267⟩
Journal articles hal-01837670v1

Transcriptomic analyses reveal rhythmic and CLOCK-driven pathways in human skeletal muscle

Laurent Perrin , Ursula Loizides-Mangold , Stéphanie Chanon , Cédric Gobet , Nicolas Hulo
eLife, 2018, 7, pp.30. ⟨10.7554/eLife.34114⟩
Journal articles hal-01847497v1

Glucose Uptake Measurement and Response to Insulin Stimulation in In Vitro Cultured Human Primary Myotubes

S. Chanon , C. Durand , A. Vieille-Marchiset , M. Robert , C. Dibner
Journal of visualized experiments : JoVE, 2017, 124, ⟨10.3791/55743⟩
Journal articles hal-01848149v1

Lipidomics reveals diurnal lipid oscillations in human skeletal muscle persisting in cellular myotubes cultured in vitro

Ursula Loizides-Mangold , Laurent Perrin , Bart Vandereycken , James Betts , Jean-Philippe Walhin
Proceedings of the National Academy of Sciences of the United States of America, 2017, 114 (41), pp.E8565 - E8574. ⟨10.1073/pnas.1705821114⟩
Journal articles hal-01827463v1

Fibroblast growth factor 19 regulates skeletal muscle mass and ameliorates muscle wasting in mice

Bérengère Benoit , Emmanuelle Fouilloux-Meugnier , Martina Castelli , Stéphanie Chanon , Aurélie Vieille-Marchiset
Nature Medicine, 2017, 23 (8), pp.990-996. ⟨10.1038/nm.4363⟩
Journal articles hal-01827292v1

Exercise training improves fat metabolism independent of total energy expenditure in sedentary overweight men, but does not restore lean metabolic phenotype

Etienne Lefai , Stéphane Blanc , Iman Momken , Edvina Antoun , Isabelle Chery
International Journal of Obesity, 2017, 41 (12), pp.1728-1736. ⟨10.1038/ijo.2017.151⟩
Journal articles hal-01613860v1

Multiple microRNA regulation of lipoprotein lipase gene abolished by 3'UTR polymorphisms in a triglyceride-lowering haplotype harboring p.Ser474Ter

Cyrielle Caussy , Sybil Charriere , Aline Meirhaeghe , Jean Dallongeville , Etienne Lefai
Atherosclerosis, 2016, 246, pp.280-286. ⟨10.1016/j.atherosclerosis.2016.01.010⟩
Journal articles hal-01986056v1

Inhibition of SOAT1 suppresses glioblastoma growth via blocking SREBP-1-mediated lipogenesis

Feng Geng , Xiang Cheng , Xiaoning Wu , Ji Young Yoo , Chunming Cheng
Clinical Cancer Research, 2016, 22 (21), pp.5337-5348. ⟨10.1158/1078-0432.CCR-15-2973⟩
Journal articles hal-01608883v1
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Transition from physical activity to inactivity increases skeletal muscle miR-148b content and triggers insulin resistance

Caroline Gastebois , Stéphanie Chanon , Sophie Rome , Christine Durand , Elise Pelascini
Physiological Reports, 2016, 4 (17), pp.e12902. ⟨10.14814/phy2.12902⟩
Journal articles hal-01398592v1
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Feedback Loop Regulation of SCAP/SREBP-1 by miR-29 Modulates EGFR Signaling-Driven Glioblastoma Growth

Peng Ru , Peng Hu , Feng Geng , Xiaokui Mo , Chunming Cheng
Cell Reports, 2016, 16 (6), pp.1527-1535. ⟨10.1016/j.celrep.2016.07.017⟩
Journal articles hal-01850292v1

Effects of training and detraining on adiponectin plasma concentration and muscle sensitivity in lean and overweight men

Caroline Gastebois , Clément Villars , Jocelyne Drai , Emmanuelle Canet-Soulas , Stéphane Blanc
European Journal of Applied Physiology, 2016, 116 (11-12), pp.2135-2144. ⟨10.1007/s00421-016-3466-z⟩
Journal articles hal-01382847v1

A TG-associated minor LPL haplotype supresses miR-29 binding on LPL 3'UTR

C. Caussy , S. Charrière , J. Dallongeville , Etienne Lefai , V. Euthine
Atherosclerosis, 2015, 241 (1), pp.e12. ⟨10.1016/j.atherosclerosis.2015.04.059⟩
Journal articles hal-02049002v1

Glucose-Mediated N-glycosylation of SCAP Is Essential for SREBP-1 Activation and Tumor Growth

C. Cheng , P. Ru , F. Geng , J. Liu , J. Y. Yoo
Cancer Cell, 2015, 28 (5), pp.569-81. ⟨10.1016/j.ccell.2015.09.021⟩
Journal articles hal-01850543v1
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Human skeletal myotubes display a cell-autonomous circadian clock implicated in basal myokine secretion

L. Perrin , U. Loizides-Mangold , S. Skarupelova , P. Pulimeno , S. Chanon
Molecular metabolism, 2015, 4 (11), pp.834-45. ⟨10.1016/j.molmet.2015.07.009⟩
Journal articles hal-01850527v1

Adipose Tissue-Derived Stem Cells From Obese Subjects Contribute to Inflammation and Reduced Insulin Response in Adipocytes Through Differential Regulation of the Th1/Th17 Balance and Monocyte Activation

A. Eljaafari , M. Robert , M. Chehimi , S. Chanon , C. Durand
Diabetes, 2015, 64 (7), pp.2477-88. ⟨10.2337/db15-0162⟩
Journal articles hal-01850502v1
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Proteomic analysis of C2C12 myoblast and myotube exosome-like vesicles: a new paradigm for myoblast-myotube cross talk?

A. Forterre , A. Jalabert , Eric Berger , M. Baudet , Karim Chikh
PLoS ONE, 2014, 9 (1), pp.e84153. ⟨10.1371/journal.pone.0084153⟩
Journal articles hal-01859453v1

A socio-ecological approach promoting physical activity and limiting sedentary behavior in adolescence showed weight benefits maintained 2.5 years after intervention cessation.

Chantal Simon , Nadir Kellou , Julien Dugas , Carine Platat , Nane Copin
International Journal of Obesity, 2014, 38 (7), pp.936-943. ⟨10.1038/ijo.2014.23⟩
Journal articles hal-00985938v1
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Exosomes participate in the alteration of muscle homeostasis during lipid-induced insulin resistance in mice

Hala Aswad , Alexis Forterre , Oscar P. B. Wiklander , Guillaume Vial , Emmanuelle Danty-Berger
Diabetologia, 2014, 57 (10), pp.2155-2164. ⟨10.1007/s00125-014-3337-2⟩
Journal articles hal-01376852v1

Effect of enforced physical inactivity induced by 60-d of bed rest on hepatic markers of NAFLD in healthy normal-weight women

Floriane Rudwill , Audrey Bergouignan , Caroline Gastebois , Guillemette Gauquelin-Koch , Etienne Lefai
Liver International, 2014, 35 (6), in press. ⟨10.1111/liv.12743⟩
Journal articles hal-01101639v1

Myostatin Gene Inactivation Prevents Skeletal Muscle Wasting in Cancer

Yann S. Gallot , Anne-Cécile Durieux , Josiane Castells , Marine M. Desgeorges , Barbara Vernus
Cancer Research, 2014, 74 (24), pp.7344-7356. ⟨10.1158/0008-5472.can-14-0057⟩
Journal articles hal-01837578v1

Myotube-derived exosomal miRNAs downregulate Sirtuin1 in myoblasts during muscle cell differentiation

A. Forterre , A. Jalabert , Karim Chikh , S. Pesenti , V. Euthine
Cell Cycle, 2014, 13 (1), pp.78-89. ⟨10.4161/cc.26808⟩
Journal articles hal-01859385v1
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Insulin resistance is associated with MCP1-mediated macrophage accumulation in skeletal muscle in mice and humans

David Patsouris , Jingwei-Ji Cao , Guillaume Vial , Amelie Bravard , Etienne Lefai
PLoS ONE, 2014, 9 (10), pp.e110653. ⟨10.1371/journal.pone.0110653⟩
Journal articles hal-01859365v1

An APOA5 3' UTR variant associated with plasma triglycerides triggers APOA5 downregulation by creating a functional miR-485-5p binding site

Cyrielle Caussy , S. Charriere , C. Marcais , M. Di Filippo , A. Sassolas
American Journal of Human Genetics, 2014, 94 (1), pp.129-34. ⟨10.1016/j.ajhg.2013.12.001⟩
Journal articles hal-01859007v1
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Bis(monoacylglycero)phosphate accumulation in macrophages induces intracellular cholesterol redistribution, attenuates liver-X receptor/ATP-Binding cassette transporter A1/ATP-binding cassette transporter G1 pathway, and impairs cholesterol efflux.

Céline Luquain-Costaz , Etienne Lefai , Maud Arnal-Levron , Daria Markina , Shota Sakaï
Arteriosclerosis, Thrombosis, and Vascular Biology, 2013, 33 (8), pp.1803-11. ⟨10.1161/ATVBAHA.113.301857⟩
Journal articles inserm-00844488v1

A liver Hif-2 alpha-Irs2 pathway sensitizes hepatic insulin signaling and is modulated by Vegf inhibition

Kevin Wei , Stephanie M. Piecewicz , Lisa M. Mcginnis , Cullen M. Taniguchi , Stanley J. Wiegand
Nature Medicine, 2013, 19 (10), pp.1331 - +. ⟨10.1038/nm.3295⟩
Journal articles hal-02643867v1

Activity energy expenditure is a major determinant of dietary fat oxidation and trafficking, but the deleterious effect of detraining is more marked than the beneficial effect of training at current recommendations.

Audrey Bergouignan , Iman Momken , Etienne Lefai , Edwina Antoun , Dale A Schoeller
The American Journal of Clinical Nutrition, 2013, 98 (3), pp.648-658. ⟨10.3945/ajcn.112.057075⟩
Journal articles hal-00866488v1
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Phospholipase D regulates the size of skeletal muscle cells through the activation of mTOR signaling.

Rami Jaafar , Joffrey de Larichaudy , Stéphanie Chanon , Vanessa Euthine , Christine Durand
Cell Communication and Signaling, 2013, 11 (1), pp.55. ⟨10.1186/1478-811X-11-55⟩
Journal articles inserm-00868745v1

Adaptive Changes of the Insig1/SREBP1/SCD1 Set Point Help Adipose Tissue to Cope With Increased Storage Demands of Obesity

Stefania Carobbio , Rachel M. Hagen , Christopher J. Lelliott , Marc Slawik , Gema Medina-Gomez
Diabetes, 2013, 62 (11), pp.3697 - 3708. ⟨10.2337/db12-1748⟩
Journal articles hal-02644218v1
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SREBP-1 transcription factors regulate skeletal muscle cell size by controlling protein synthesis through myogenic regulatory factors.

Kevin Dessalle , Vanessa Euthine , Stéphanie Chanon , Joffrey de Larichaudy , Isao Fujii
PLoS ONE, 2012, 7 (11), pp.e50878. ⟨10.1371/journal.pone.0050878⟩
Journal articles inserm-00809752v1

Validity of combining heart rate and uniaxial acceleration to measure free-living physical activity energy expenditure in young men.

Clement Villars , Audrey Bergouignan , Julien Dugas , Edwina Antoun , Dale Alan Schoeller
Journal of Applied Physiology, 2012, 113 (11), pp.1763-1771. ⟨10.1152/japplphysiol.01413.2011⟩
Journal articles hal-00751256v1
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TNF-α- and tumor-induced skeletal muscle atrophy involves sphingolipid metabolism.

Joffrey de Larichaudy , Alessandra Zufferli , Filippo Serra , Andrea Isidori , Fabio Naro
Skeletal Muscle, 2012, 2 (1), pp.2. ⟨10.1186/2044-5040-2-2⟩
Journal articles inserm-00694560v1
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Sirtuin 1 Regulates SREBP-1c Expression in a LXR-Dependent Manner in Skeletal Muscle

Aurélia Defour , Kevin Dessalle , Andréa Castro Perez , Thomas Poyot , Josiane Castells
PLoS ONE, 2012, 7 (9), pp.e43490. ⟨10.1371/journal.pone.0043490⟩
Journal articles hal-01779124v1

GPIHBP1 C89F neomutation and hydrophobic C-terminal domain G175R mutation in two pedigrees with severe hyperchylomicronemia

Sybil Charriere , Noël Peretti , Sophie Bernard , Mathilde Di Filippo , Agnes Sassolas
Journal of Clinical Endocrinology and Metabolism, 2011, 96 (10), ⟨10.1210/jc.2011-1444⟩
Journal articles hal-02652262v1

AMPK Phosphorylates and Inhibits SREBP Activity to Attenuate Hepatic Steatosis and Atherosclerosis in Diet-Induced Insulin-Resistant Mice

Yu Li , Shanqin Xu , Maria M. Mihaylova , Bin Zheng , Xiuyun Hou
Cell Metabolism, 2011, 13 (4), pp.376 - 388. ⟨10.1016/j.cmet.2011.03.009⟩
Journal articles hal-02651599v1
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FTO is increased in muscle during type 2 diabetes, and its overexpression in myotubes alters insulin signaling, enhances lipogenesis and ROS production, and induces mitochondrial dysfunction.

Amélie Bravard , Etienne Lefai , Emmanuelle Fouilloux-Meugnier , Sandra Pesenti , Emmanuel Disse
Diabetes, 2011, 60 (1), pp.258-68. ⟨10.2337/db10-0281⟩
Journal articles inserm-00809741v1
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Phospholipase D regulates myogenic differentiation through the activation of both mTORC1 and mTORC2 complexes.

Rami Jaafar , Caroline Zeiller , Luciano Pirola , Antonio Di Grazia , Fabio Naro
Journal of Biological Chemistry, 2011, 286 (25), pp.22609-21. ⟨10.1074/jbc.M110.203885⟩
Journal articles inserm-00817714v1
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Pdro, a protein associated with late endosomes and lysosomes and implicated in cellular cholesterol homeostasis.

Patricia Guillaumot , Céline Luquain , Mouhannad Malek , Anne-Laure Huber , Sabine Brugière
PLoS ONE, 2010, 5 (6), pp.e10977. ⟨10.1371/journal.pone.0010977⟩
Journal articles inserm-00763417v1

FTO Is Increased in Muscle During Type 2 Diabetes, and Its Overexpression in Myotubes Alters Insulin Signaling, Enhances Lipogenesis and ROS Production, and Induces Mitochondrial Dysfunction

A. Bravard , Etienne Lefai , E. Meugnier , S. Pesenti , Emmanuel Disse
Diabetes, 2010, 60 (1), pp.258-268
Journal articles hal-01982013v1

A New Role for Sterol Regulatory Element Binding Protein 1 Transcription Factors in the Regulation of Muscle Mass and Muscle Cell Differentiation

V. Lecomte , E. Meugnier , V. Euthine , C. Durand , D. Freyssenet
Molecular and Cellular Biology, 2010, 30 (5), pp.1182-1198
Journal articles hal-01982021v1
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Downregulation of Akt/mammalian target of rapamycin pathway in skeletal muscle is associated with increased REDD1 expression in response to chronic hypoxia.

François Bertrand Favier , Frédéric Costes , Aurélia Defour , Régis Bonnefoy , Etienne Lefai
AJP - Regulatory, Integrative and Comparative Physiology, 2010, 298 (6), pp.R1659-66. ⟨10.1152/ajpregu.00550.2009⟩
Journal articles inserm-00593929v1
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A new role for sterol regulatory element binding protein 1 transcription factors in the regulation of muscle mass and muscle cell differentiation.

Virginie Lecomte , Emmanuelle Meugnier , Vanessa Euthine , Christine Durand , Damien Freyssenet
Molecular and Cellular Biology, 2010, 30 (5), pp.1182-98. ⟨10.1128/MCB.00690-09⟩
Journal articles inserm-00817651v1
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The microRNA signature in response to insulin reveals its implication in the transcriptional action of insulin in human skeletal muscle and the role of a sterol regulatory element-binding protein-1c/myocyte enhancer factor 2C pathway.

Aurélie Granjon , Marie-Paule Gustin , Jennifer Rieusset , Etienne Lefai , Emmanuelle Meugnier
Diabetes, 2009, 58 (11), pp.2555-64. ⟨10.2337/db09-0165⟩
Journal articles inserm-00808523v1

Microarray analysis of genes with impaired insulin regulation in the skeletal muscle of type 2 diabetic patients indicates the involvement of basic helix-loop-helix domain-containing, class B, 2 protein (BHLHB2)

Sophie Rome , E. Meugnier , V. Lecomte , V. Berbe , J. Besson
Diabetologia, 2009, 52 (9), pp.1899-1912
Journal articles hal-01982031v1

The microRNA Signature in Response to Insulin Reveals Its Implication in the Transcriptional Action of Insulin in Human Skeletal Muscle and the Role of a Sterol Regulatory Element-Binding Protein-1c/Myocyte Enhancer Factor 2C Pathway

A. Granjon , M.-P. Gustin , Jennifer Rieusset , Etienne Lefai , E. Meugnier
Diabetes, 2009, 58 (11), pp.2555-2564
Journal articles hal-01982029v1
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Microarray analyses of SREBP-1a and SREBP-1c target genes identify new regulatory pathways in muscle.

Sophie Rome , Virginie Lecomte , Emmanuelle Meugnier , Jennifer Rieusset , Cyrille Debard
Physiological Genomics, 2008, 34 (3), pp.327-37. ⟨10.1152/physiolgenomics.90211.2008⟩
Journal articles inserm-00809732v1

Microarray analyses of SREBP-1a and SREBP-1c target genes identify new regulatory pathways in muscle

Sophie Rome , Virginie Lecomte , Emmanuelle Fouilloux-Meugnier , Jennifer Rieusset , Cyrille Debard
Physiological Genomics, 2008, 34 (3), pp.327-337
Journal articles hal-01982035v1
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Insulin activates human sterol-regulatory-element-binding protein-1c (SREBP-1c) promoter through SRE motifs

Nicolas Dif , Vanessa Euthine , Estelle Gonnet , Martine Laville , Hubert Vidal
Biochemical Journal, 2006, 400 (1), pp.179-188. ⟨10.1042/BJ20060499⟩
Journal articles hal-00478570v1

Regulation of SREBP-1 expression and transcriptional action on HKII and FAS genes during fasting and refeeding in rat tissues

Yvan Gosmain , Nicolas Dif , Vanessa Euthine , Emmanuelle Loizon , Jennifer J. Rieusset
Journal of Lipid Research, 2005, 46 (4), pp.697-705
Journal articles hal-02048999v1

Expression of the splice variants of the p85alpha regulatory subunit of phosphoinositide 3-kinase in muscle and adipose tissue of healthy subjects and type 2 diabetic patients

Etienne Lefai , M. Roques , Nathalie Vega , M. Laville , Hubert Vidal
Biochemical Journal, 2001, 360, pp.117-125
Journal articles hal-02673828v1

Innovative approaches for an in- depth quantitative analysis of the serum proteome of brown bears

Alexandre Geffroy , Hugo Gizardin-Fredon , Jon Arnemo , Jonas Kindberg , Sarah Cianferani
72nd ASMS Conference on Mass Spectrometry and Allied Topics, Jun 2024, Anaheim (CA), United States
Conference papers hal-04437952v1

Effect of hibernating bear serum effect on human myotubes transcriptome: BMP signaling regulation

Chloé Richard , Guillaume Fourneaux , Alexandre Geffroy , Cécile Coudy-Gandilhon , Gwendal Cueff
6e Congrès de la Société de Physiologie et Biologie Intégrative, Jul 2023, Clermont-Ferrand, France
Conference papers hal-04209952v1

Concurrent BMP maintenance and TGFβ inhibition is a hallmark of bear resistance to muscle atrophy

Laura Cussonneau , Emeric Dubois , Jon Arnemo , Fabrice Bertile , Lydie Combaret
16th International Hibernation Symposium, Aug 2021, Groningen, The Netherlands, France
Conference papers hal-04209832v1

Concurrent BMP signaling maintenance and TGF- β signaling inhibition is a hallmark of natural resistance to muscle atrophy

Laura Cussonneau , Christian Boyer , Emmanuelle Meugnier , Guillemette Gauquelin-Koch , Jon Arnemo
Congrès des jeunes chercheurs en Biologie de la région AURA, Jun 2021, Lyon ( virtual ), France
Conference papers hal-04209580v1

Concurrent BMP signaling maintenance and TGF- β signaling inhibition is a hallmark of natural resistance to muscle atrophy

Laura Cussonneau , Christian Boyer , Emmanuelle Meugnier , Guillemette Gauquelin-Koch , Jon Arnemo
18èmes Journées de la Société Française de Myologie, Nov 2021, Saint-Etienne, France
Conference papers hal-04209791v1

Physical inactivity and preservation of muscle mass: Lessons from Hibernation

Etienne Lefai
Nobel Conference: Bioinspirational medicine – Using nature to unlock access to opportunities in health, Sep 2019, Stockholm, Sweden
Conference papers hal-02285609v1

Integral lipidomic analysis of human skeletal muscle and visceral adipose tissue biopsy samples from lean, obese and type 2 diabetic individuals

Ursula Loizides-Mangold , Stéphanie Chanon , M. Robert , Etienne Lefai , Charna Dibner
54. Annual Meeting of the European-Association-for-the-Study-of-Diabetes (EASD), Oct 2018, berlin, Germany
Conference papers hal-02733993v1

The study of hibernation in bears to improve human health

Etienne Lefai
2018 Arctic Circle, Oct 2018, Reykjavik, Iceland
Conference papers hal-01984299v1

Adipose stem cells contribute to inflammation and insulin resistance through both TH-17 polarisation and increased pro-inflammatory cytokine secretion

A. Eljaafari , Maud Robert , Bilal Osta , Marwa Chehimi , Christine Durand
49. Annual Meeting of the European-Association-for-the-Study-of-Diabetes (EASD), European Association for the Study of Diabetes (EASD). GBR., Sep 2013, Barcelone, Spain
Conference papers hal-02741210v1