EL

Etienne Lefai

58 %
Libre accès
106
Documents
Affiliations actuelles
  • Unité de Nutrition Humaine (UNH)
  • Université Clermont Auvergne (UCA)
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Publications

Publications

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The Preservation of Muscle Mitochondrial Machinery During Hypometabolic Hibernation in Scandinavian Brown Bears (Ursus arctos)

Audrey Bergouignan , John Noone , Charlotte Brun , Laura Cussonneau , Alexandre Geffroy et al.

Acta Physiologica, In press, ⟨10.1111/apha.70177⟩

Article dans une revue hal-05527807v1
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Reduced ATP turnover during hibernation in relaxed skeletal muscle

Cosimo de Napoli , Luisa Schmidt , Mauro Montesel , Laura Cussonneau , Samuele Sanniti et al.

Nature Communications, 2025, 16 (1), pp.80. ⟨10.1038/s41467-024-55565-4⟩

Article dans une revue hal-04892800v1

Targeting PGM3 abolishes SREBP-1 activation-hexosamine synthesis feedback regulation to effectively suppress brain tumor growth

Huali Su , Yaogang Zhong , Liqing He , Feng Geng , Xinmin Yin et al.

Science Advances , 2025, 11 (16), ⟨10.1126/sciadv.adq0334⟩

Article dans une revue hal-05446764v1
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Structure predictions of MuRF 1‐ UBE2 complexes identify amino acid residues governing interaction selectivity for each MuRF 1‐ E2 pair

Agnès Claustre , Mélodie Malige , Maëlys Macheton , Lydie Combaret , Etienne Lefai et al.

FEBS Journal, 2025, 292 (10), pp.2559-2577. ⟨10.1111/febs.70017⟩

Article dans une revue hal-04993910v1

Protein synthesis, autophagy, and regeneration-related signaling in fast/slow muscles in two mammalian models of disuse

Xuli Gao , Weilan Miao , Yuting Han , Yingyu Yang , Ning An et al.

Canadian Journal of Zoology, 2025, 103, pp.0061. ⟨10.1139/cjz-2024-0061⟩

Article dans une revue hal-05446749v1
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Involvement of Melatonin, Oxidative Stress, and Inflammation in the Protective Mechanism of the Carotid Artery over the Torpor–Arousal Cycle of Ground Squirrels

Ziwei Hao , Yuting Han , Qi Zhao , Minghui Zhu , Xiaoxuan Liu et al.

International Journal of Molecular Sciences, 2024, 25 (23), pp.12888. ⟨10.3390/ijms252312888⟩

Article dans une revue hal-04892799v1
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Alterations of lipid homeostasis in morbid obese patients are partly reversed by bariatric surgery

Flore Sinturel , Simona Chera , Marie-Claude Brulhart-Meynet , Jonathan Paz Montoya , Etienne Lefai et al.

iScience, 2024, 27 (9), pp.110820. ⟨10.1016/j.isci.2024.110820⟩

Article dans une revue hal-04753955v1
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Combinatorial targeting of glutamine metabolism and lysosomal-based lipid metabolism effectively suppresses glioblastoma

Yaogang Zhong , Feng Geng , Logan Mazik , Xinmin Yin , Aline Paixao Becker et al.

Cell Reports Medicine, 2024, 5 (9), pp.101706. ⟨10.1016/j.xcrm.2024.101706⟩

Article dans une revue hal-04794783v1
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STAT3 activation of SCAP-SREBP-1 signaling upregulates fatty acid synthesis to promote tumor growth

Yunzhou Fan , Rui Zhang , Chao Wang , Meixia Pan , Feng Geng et al.

Journal of Biological Chemistry, 2024, 300 (6), pp.107351. ⟨10.1016/j.jbc.2024.107351⟩

Article dans une revue hal-04892802v1
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Induction of ATF4-Regulated Atrogenes Is Uncoupled from Muscle Atrophy during Disuse in Halofuginone-Treated Mice and in Hibernating Brown Bears

Laura Cussonneau , Cécile Coudy-Gandilhon , Christiane Deval , Ghita Chaouki , Mehdi M. Djelloul-Mazouz et al.

International Journal of Molecular Sciences, 2023, 24 (1), pp.621. ⟨10.3390/ijms24010621⟩

Article dans une revue hal-04178468v1
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SREBP-1 upregulates lipophagy to maintain cholesterol homeostasis in brain tumor cells

Feng Geng , Yaogang Zhong , Huali Su , Etienne Lefai , Shino Magaki et al.

Cell Reports, 2023, 42 (7), pp.112790. ⟨10.1016/j.celrep.2023.112790⟩

Article dans une revue hal-04279038v1
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ANGPTL4 is a potential driver of HCV-induced peripheral insulin resistance

Diana Gomes , Cyril Sobolewski , Stéphanie Conzelmann , Tifany Schaer , Etienne Lefai et al.

Scientific Reports, 2023, 13 (1), pp.6767. ⟨10.1038/s41598-023-33728-5⟩

Article dans une revue hal-04176948v1

Differential bone remodeling mechanism in hindlimb unloaded and hibernating Daurian ground squirrels: a comparison between artificial and natural disuse within the same species

Xuli Gao , Siqi Wang , Siqi Shen , Shuyao Wang , Manjiang Xie et al.

Journal of Comparative Physiology B, 2023, 193 (3), pp.329-350. ⟨10.1007/s00360-023-01482-9⟩

Article dans une revue hal-04288563v1

Integrated transcriptomics and metabolomics reveal protective effects on heart of hibernating Daurian ground squirrels

Yingyu Yang , Ziwei Hao , Ning An , Yuting Han , Weilan Miao et al.

Journal of Cellular Physiology, 2023, ⟨10.1002/jcp.31123⟩

Article dans une revue hal-04279721v1
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The Protective Effects on Ischemia–Reperfusion Injury Mechanisms of the Thoracic Aorta in Daurian Ground Squirrels (Spermophilus dauricus) over the Torpor–Arousal Cycle of Hibernation

Yuting Han , Weilan Miao , Ziwei Hao , Ning An , Yingyu Yang et al.

International Journal of Molecular Sciences, 2022, 23 (18), pp.10248. ⟨10.3390/ijms231810248⟩

Article dans une revue hal-03842443v1
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Cardiomyocyte Protection by Hibernating Brown Bear Serum: Toward the Identification of New Protective Molecules Against Myocardial Infarction

Lucas Givre , Claire Crola da Silva , Jon E Swenson , Jon M Arnemo , Guillemette Gauquelin-Koch et al.

Frontiers in Cardiovascular Medicine, 2021, 8, pp.687501. ⟨10.3389/fcvm.2021.687501⟩

Article dans une revue hal-03419383v1
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Hibernating brown bears are protected against atherogenic dyslipidemia

Sylvain Giroud , Isabelle Chery , Mathilde Arrivé , Michel Prost , Julie Zumsteg et al.

Scientific Reports, 2021, 11 (1), ⟨10.1038/s41598-021-98085-7⟩

Article dans une revue hal-03360652v1
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Ether lipids, sphingolipids and toxic 1-deoxyceramides as hallmarks for lean and obese type 2 diabetic patients

J. T. Hannich , U. Loizides-Mangold , F. Sinturel , T. Harayama , B. Vandereycken et al.

Acta Physiologica, 2021, 232 (1), pp.e13610. ⟨10.1111/apha.13610⟩

Article dans une revue inserm-03269069v1
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Concurrent BMP Signaling Maintenance and TGF-β Signaling Inhibition Is a Hallmark of Natural Resistance to Muscle Atrophy in the Hibernating Bear

Laura Cussonneau , Christian Boyer , Charlotte Brun , Christiane Deval , Emmanuelle Loizon et al.

Cells, 2021, 10 (8), pp.1873. ⟨10.3390/cells10081873⟩

Article dans une revue hal-03314541v1
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ANT2-Mediated ATP Import into Mitochondria Protects against Hypoxia Lethal Injury

Yves Gouriou , Muhammad Rizwan Alam , Zeina Harhous , Claire Crola Da Silva , Delphine Baetz et al.

Cells, 2020, Cell Signaling, 9 (12), pp.2542. ⟨10.3390/cells9122542⟩

Article dans une revue hal-03060378v1
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Specific shifts in the endocannabinoid system in hibernating brown bears

Christian Boyer , Laura Cussonneau , Charlotte Brun , Christiane Deval , Jean-Paul Pais de Barros et al.

Frontiers in Zoology, 2020, 17, pp.35. ⟨10.1186/s12983-020-00380-y⟩

Article dans une revue hal-03054587v1
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MicroRNAs facilitate skeletal muscle maintenance and metabolic suppression in hibernating brown bears

Bryan E. Luu , Etienne Lefai , Sylvain Giroud , Jon E. Swenson , Blandine Chazarin et al.

Journal of Cellular Physiology, 2020, 235 (4), pp.3984-3993. ⟨10.1002/jcp.29294⟩

Article dans une revue hal-02349938v1
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Hypergravity as a gravitational therapy mitigates the effects of knee osteoarthritis on the musculoskeletal system in a murine model

Benoit Dechaumet , Damien Cleret , Marie-Thérèse Linossier , Arnaud Vanden-Bossche , Stéphanie Chanon et al.

PLoS ONE, 2020, 15 (12), pp.e0243098. ⟨10.1371/journal.pone.0243098⟩

Article dans une revue hal-03152504v1
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Metabolic reprogramming involving glycolysis in the hibernating brown bear skeletal muscle

Blandine Chazarin , Kenneth B Storey , Anna Ziemianin , Stéphanie Chanon , Marine Plumel et al.

Frontiers in Zoology, 2019, 16, pp.12. ⟨10.1186/s12983-019-0312-2⟩

Article dans une revue hal-02149735v1
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Limited Oxidative Stress Favors Resistance to Skeletal Muscle Atrophy in Hibernating Brown Bears (Ursus Arctos)

Blandine Chazarin , Anna Ziemianin , Alina L. Evans , Emmanuelle Meugnier , Emmanuelle Loizon et al.

Antioxidants , 2019, 8 (9), pp.334. ⟨10.3390/antiox8090334⟩

Article dans une revue hal-02274540v1
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A nutrient cocktail prevents lipid metabolism alterations induced by 20 days of daily steps reduction and fructose overfeeding: Result from a randomized study

Anthony Damiot , Rémi Demangel , John Noone , Isabelle Chery , Alexandre Zahariev et al.

Journal of Applied Physiology, 2019, 126 (1), pp.88-101. ⟨10.1152/japplphysiol.00018.2018⟩

Article dans une revue hal-01918097v1
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In-Depth Proteome Analysis Highlights HepaRG Cells as a Versatile Cell System Surrogate for Primary Human Hepatocytes

Georg Tascher , Audrey Burban , Sandrine Camus , Marine Plumel , Stéphanie Chanon et al.

Cells, 2019, 8 (2), pp.E192. ⟨10.3390/cells8020192⟩

Article dans une revue hal-02050391v1
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Lipidomics Reveals Seasonal Shifts in a Large-Bodied Hibernator, the Brown Bear

Sylvain Giroud , Isabelle Chery , Fabrice Bertile , Justine Bertrand-Michel , Georg Tascher et al.

Frontiers in Physiology, 2019, 10, ⟨10.3389/fphys.2019.00389⟩

Article dans une revue hal-02141629v1
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TRPV1 variants impair intracellular Ca2+ signaling and may confer susceptibility to malignant hyperthermia

Fabien Vanden Abeele , Sabine Lotteau , Sylvie Ducreux , Charlotte Dubois , Nicole Monnier et al.

Genetics in Medicine, 2019, 21 (2), pp.441-450. ⟨10.1038/s41436-018-0066-9⟩

Article dans une revue hal-02475163v1
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Proteolysis inhibition by hibernating bear serum leads to increased protein content in human muscle cells

Stéphanie Chanon , Blandine Chazarin , Benoit Toubhans , Christine Durand , Isabelle Chery et al.

Scientific Reports, 2018, 8 (1), pp.1-10. ⟨10.1038/s41598-018-23891-5⟩

Article dans une revue hal-01772255v1

Disruption of Mitochondria-Associated Endoplasmic Reticulum Membrane (MAM) Integrity Contributes to Muscle Insulin Resistance in Mice and Humans

Emily Tubbs , Stéphanie Chanon , Maud Robert , Nadia Bendridi , Gabriel Bidaux et al.

Diabetes, 2018, 67 (4), pp.636-650. ⟨10.2337/db17-0316⟩

Article dans une revue hal-01847407v1

Metabolic inflexibility is an early marker of bed-rest–induced glucose intolerance even when fat mass is stable

Floriane Rudwill , Donal O’gorman , Etienne Lefai , Isabelle Chery , Alexandre Zahariev et al.

Journal of Clinical Endocrinology and Metabolism, 2018, 103 (5), pp.1910-1920. ⟨10.1210/jc.2017-02267⟩

Article dans une revue hal-01837670v1

Seasonal changes in eicosanoid metabolism in the brown bear

Sylvain Giroud , Alina M Evans , Isabelle Chery , Fabrice Bertile , Georg Tascher et al.

The Science of Nature Naturwissenschaften, 2018, 105 (9-10), ⟨10.1007/s00114-018-1583-8⟩

Article dans une revue hal-01907890v1

Transcriptomic analyses reveal rhythmic and CLOCK-driven pathways in human skeletal muscle

Laurent Perrin , Ursula Loizides-Mangold , Stéphanie Chanon , Cédric Gobet , Nicolas Hulo et al.

eLife, 2018, 7, pp.30. ⟨10.7554/eLife.34114⟩

Article dans une revue hal-01847497v1

Glucose Uptake Measurement and Response to Insulin Stimulation in In Vitro Cultured Human Primary Myotubes

S. Chanon , C. Durand , A. Vieille-Marchiset , M. Robert , C. Dibner et al.

Journal of visualized experiments : JoVE, 2017, 124, ⟨10.3791/55743⟩

Article dans une revue hal-01848149v1

Exercise training improves fat metabolism independent of total energy expenditure in sedentary overweight men, but does not restore lean metabolic phenotype

Etienne Lefai , Stéphane Blanc , Iman Momken , Edvina Antoun , Isabelle Chery et al.

International Journal of Obesity, 2017, 41 (12), pp.1728-1736. ⟨10.1038/ijo.2017.151⟩

Article dans une revue hal-01613860v1

Fibroblast growth factor 19 regulates skeletal muscle mass and ameliorates muscle wasting in mice

Bérengère Benoit , Emmanuelle Fouilloux-Meugnier , Martina Castelli , Stéphanie Chanon , Aurélie Vieille-Marchiset et al.

Nature Medicine, 2017, 23 (8), pp.990-996. ⟨10.1038/nm.4363⟩

Article dans une revue hal-01827292v1

Lipidomics reveals diurnal lipid oscillations in human skeletal muscle persisting in cellular myotubes cultured in vitro

Ursula Loizides-Mangold , Laurent Perrin , Bart Vandereycken , James Betts , Jean-Philippe Walhin et al.

Proceedings of the National Academy of Sciences of the United States of America, 2017, 114 (41), pp.E8565 - E8574. ⟨10.1073/pnas.1705821114⟩

Article dans une revue hal-01827463v1
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Feedback Loop Regulation of SCAP/SREBP-1 by miR-29 Modulates EGFR Signaling-Driven Glioblastoma Growth

Peng Ru , Peng Hu , Feng Geng , Xiaokui Mo , Chunming Cheng et al.

Cell Reports, 2016, 16 (6), pp.1527-1535. ⟨10.1016/j.celrep.2016.07.017⟩

Article dans une revue hal-01850292v1
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Transition from physical activity to inactivity increases skeletal muscle miR-148b content and triggers insulin resistance

Caroline Gastebois , Stéphanie Chanon , Sophie Rome , Christine Durand , Elise Pelascini et al.

Physiological Reports, 2016, 4 (17), pp.e12902. ⟨10.14814/phy2.12902⟩

Article dans une revue hal-01398592v1

Multiple microRNA regulation of lipoprotein lipase gene abolished by 3'UTR polymorphisms in a triglyceride-lowering haplotype harboring p.Ser474Ter

Cyrielle Caussy , Sybil Charriere , Aline Meirhaeghe , Jean Dallongeville , Etienne Lefai et al.

Atherosclerosis, 2016, 246, pp.280-286. ⟨10.1016/j.atherosclerosis.2016.01.010⟩

Article dans une revue istex hal-01986056v1

Inhibition of SOAT1 suppresses glioblastoma growth via blocking SREBP-1-mediated lipogenesis

Feng Geng , Xiang Cheng , Xiaoning Wu , Ji Young Yoo , Chunming Cheng et al.

Clinical Cancer Research, 2016, 22 (21), pp.5337-5348. ⟨10.1158/1078-0432.CCR-15-2973⟩

Article dans une revue hal-01608883v1

Effects of training and detraining on adiponectin plasma concentration and muscle sensitivity in lean and overweight men

Caroline Gastebois , Clément Villars , Jocelyne Drai , Emmanuelle Canet-Soulas , Stéphane Blanc et al.

European Journal of Applied Physiology, 2016, 116 (11-12), pp.2135-2144. ⟨10.1007/s00421-016-3466-z⟩

Article dans une revue hal-01382847v1

A TG-associated minor LPL haplotype supresses miR-29 binding on LPL 3'UTR

C. Caussy , S. Charrière , J. Dallongeville , Etienne Lefai , V. Euthine et al.

Atherosclerosis, 2015, 241 (1), pp.e12. ⟨10.1016/j.atherosclerosis.2015.04.059⟩

Article dans une revue hal-02049002v1

Adipose Tissue-Derived Stem Cells From Obese Subjects Contribute to Inflammation and Reduced Insulin Response in Adipocytes Through Differential Regulation of the Th1/Th17 Balance and Monocyte Activation

A. Eljaafari , M. Robert , M. Chehimi , S. Chanon , C. Durand et al.

Diabetes, 2015, 64 (7), pp.2477-88. ⟨10.2337/db15-0162⟩

Article dans une revue hal-01850502v1
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Human skeletal myotubes display a cell-autonomous circadian clock implicated in basal myokine secretion

L. Perrin , U. Loizides-Mangold , S. Skarupelova , P. Pulimeno , S. Chanon et al.

Molecular metabolism, 2015, 4 (11), pp.834-45. ⟨10.1016/j.molmet.2015.07.009⟩

Article dans une revue hal-01850527v1

Glucose-Mediated N-glycosylation of SCAP Is Essential for SREBP-1 Activation and Tumor Growth

C. Cheng , P. Ru , F. Geng , J. Liu , J. Y. Yoo et al.

Cancer Cell, 2015, 28 (5), pp.569-81. ⟨10.1016/j.ccell.2015.09.021⟩

Article dans une revue hal-01850543v1
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Insulin resistance is associated with MCP1-mediated macrophage accumulation in skeletal muscle in mice and humans

David Patsouris , Jingwei-Ji Cao , Guillaume Vial , Amelie Bravard , Etienne Lefai et al.

PLoS ONE, 2014, 9 (10), pp.e110653. ⟨10.1371/journal.pone.0110653⟩

Article dans une revue hal-01859365v1

Myotube-derived exosomal miRNAs downregulate Sirtuin1 in myoblasts during muscle cell differentiation

A. Forterre , A. Jalabert , Karim Chikh , S. Pesenti , V. Euthine et al.

Cell Cycle, 2014, 13 (1), pp.78-89. ⟨10.4161/cc.26808⟩

Article dans une revue hal-01859385v1

Myostatin Gene Inactivation Prevents Skeletal Muscle Wasting in Cancer

Yann S. Gallot , Anne-Cécile Durieux , Josiane Castells , Marine M. Desgeorges , Barbara Vernus et al.

Cancer Research, 2014, 74 (24), pp.7344-7356. ⟨10.1158/0008-5472.can-14-0057⟩

Article dans une revue hal-01837578v1
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Proteomic analysis of C2C12 myoblast and myotube exosome-like vesicles: a new paradigm for myoblast-myotube cross talk?

A. Forterre , A. Jalabert , Eric Berger , M. Baudet , Karim Chikh et al.

PLoS ONE, 2014, 9 (1), pp.e84153. ⟨10.1371/journal.pone.0084153⟩

Article dans une revue hal-01859453v1

A socio-ecological approach promoting physical activity and limiting sedentary behavior in adolescence showed weight benefits maintained 2.5 years after intervention cessation.

Chantal Simon , Nadir Kellou , Julien Dugas , Carine Platat , Nane Copin et al.

International Journal of Obesity, 2014, 38 (7), pp.936-943. ⟨10.1038/ijo.2014.23⟩

Article dans une revue hal-00985938v1
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Exosomes participate in the alteration of muscle homeostasis during lipid-induced insulin resistance in mice

Hala Aswad , Alexis Forterre , Oscar P. B. Wiklander , Guillaume Vial , Emmanuelle Danty-Berger et al.

Diabetologia, 2014, 57 (10), pp.2155-2164. ⟨10.1007/s00125-014-3337-2⟩

Article dans une revue hal-01376852v1

Effect of enforced physical inactivity induced by 60-d of bed rest on hepatic markers of NAFLD in healthy normal-weight women

Floriane Rudwill , Audrey Bergouignan , Caroline Gastebois , Guillemette Gauquelin-Koch , Etienne Lefai et al.

Liver International, 2014, 35 (6), in press. ⟨10.1111/liv.12743⟩

Article dans une revue istex hal-01101639v1

An APOA5 3' UTR variant associated with plasma triglycerides triggers APOA5 downregulation by creating a functional miR-485-5p binding site

Cyrielle Caussy , S. Charriere , C. Marcais , M. Di Filippo , A. Sassolas et al.

American Journal of Human Genetics, 2014, 94 (1), pp.129-34. ⟨10.1016/j.ajhg.2013.12.001⟩

Article dans une revue hal-01859007v1
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Bis(monoacylglycero)phosphate accumulation in macrophages induces intracellular cholesterol redistribution, attenuates liver-X receptor/ATP-Binding cassette transporter A1/ATP-binding cassette transporter G1 pathway, and impairs cholesterol efflux.

Céline Luquain-Costaz , Etienne Lefai , Maud Arnal-Levron , Daria Markina , Shota Sakaï et al.

Arteriosclerosis, Thrombosis, and Vascular Biology, 2013, 33 (8), pp.1803-11. ⟨10.1161/ATVBAHA.113.301857⟩

Article dans une revue inserm-00844488v1

Adaptive Changes of the Insig1/SREBP1/SCD1 Set Point Help Adipose Tissue to Cope With Increased Storage Demands of Obesity

Stefania Carobbio , Rachel M. Hagen , Christopher J. Lelliott , Marc Slawik , Gema Medina-Gomez et al.

Diabetes, 2013, 62 (11), pp.3697 - 3708. ⟨10.2337/db12-1748⟩

Article dans une revue hal-02644218v1
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Phospholipase D regulates the size of skeletal muscle cells through the activation of mTOR signaling.

Rami Jaafar , Joffrey de Larichaudy , Stéphanie Chanon , Vanessa Euthine , Christine Durand et al.

Cell Communication and Signaling, 2013, 11 (1), pp.55. ⟨10.1186/1478-811X-11-55⟩

Article dans une revue inserm-00868745v1

A liver Hif-2 alpha-Irs2 pathway sensitizes hepatic insulin signaling and is modulated by Vegf inhibition

Kevin Wei , Stephanie M. Piecewicz , Lisa M. Mcginnis , Cullen M. Taniguchi , Stanley J. Wiegand et al.

Nature Medicine, 2013, 19 (10), pp.1331 - +. ⟨10.1038/nm.3295⟩

Article dans une revue hal-02643867v1

Activity energy expenditure is a major determinant of dietary fat oxidation and trafficking, but the deleterious effect of detraining is more marked than the beneficial effect of training at current recommendations.

Audrey Bergouignan , Iman Momken , Etienne Lefai , Edwina Antoun , Dale A Schoeller et al.

The American Journal of Clinical Nutrition, 2013, 98 (3), pp.648-658. ⟨10.3945/ajcn.112.057075⟩

Article dans une revue hal-00866488v1
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SREBP-1 transcription factors regulate skeletal muscle cell size by controlling protein synthesis through myogenic regulatory factors.

Kevin Dessalle , Vanessa Euthine , Stéphanie Chanon , Joffrey de Larichaudy , Isao Fujii et al.

PLoS ONE, 2012, 7 (11), pp.e50878. ⟨10.1371/journal.pone.0050878⟩

Article dans une revue inserm-00809752v1
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TNF-α- and tumor-induced skeletal muscle atrophy involves sphingolipid metabolism.

Joffrey de Larichaudy , Alessandra Zufferli , Filippo Serra , Andrea Isidori , Fabio Naro et al.

Skeletal Muscle, 2012, 2 (1), pp.2. ⟨10.1186/2044-5040-2-2⟩

Article dans une revue inserm-00694560v1

Validity of combining heart rate and uniaxial acceleration to measure free-living physical activity energy expenditure in young men.

Clement Villars , Audrey Bergouignan , Julien Dugas , Edwina Antoun , Dale Alan Schoeller et al.

Journal of Applied Physiology, 2012, 113 (11), pp.1763-1771. ⟨10.1152/japplphysiol.01413.2011⟩

Article dans une revue hal-00751256v1
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Sirtuin 1 Regulates SREBP-1c Expression in a LXR-Dependent Manner in Skeletal Muscle

Aurélia Defour , Kevin Dessalle , Andréa Castro Perez , Thomas Poyot , Josiane Castells et al.

PLoS ONE, 2012, 7 (9), pp.e43490. ⟨10.1371/journal.pone.0043490⟩

Article dans une revue hal-01779124v1

GPIHBP1 C89F neomutation and hydrophobic C-terminal domain G175R mutation in two pedigrees with severe hyperchylomicronemia

Sybil Charriere , Noël Peretti , Sophie Bernard , Mathilde Di Filippo , Agnes Sassolas et al.

Journal of Clinical Endocrinology and Metabolism, 2011, 96 (10), ⟨10.1210/jc.2011-1444⟩

Article dans une revue hal-02652262v1
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Phospholipase D regulates myogenic differentiation through the activation of both mTORC1 and mTORC2 complexes.

Rami Jaafar , Caroline Zeiller , Luciano Pirola , Antonio Di Grazia , Fabio Naro et al.

Journal of Biological Chemistry, 2011, 286 (25), pp.22609-21. ⟨10.1074/jbc.M110.203885⟩

Article dans une revue inserm-00817714v1
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FTO is increased in muscle during type 2 diabetes, and its overexpression in myotubes alters insulin signaling, enhances lipogenesis and ROS production, and induces mitochondrial dysfunction.

Amélie Bravard , Etienne Lefai , Emmanuelle Fouilloux-Meugnier , Sandra Pesenti , Emmanuel Disse et al.

Diabetes, 2011, 60 (1), pp.258-68. ⟨10.2337/db10-0281⟩

Article dans une revue inserm-00809741v1

AMPK Phosphorylates and Inhibits SREBP Activity to Attenuate Hepatic Steatosis and Atherosclerosis in Diet-Induced Insulin-Resistant Mice

Yu Li , Shanqin Xu , Maria M. Mihaylova , Bin Zheng , Xiuyun Hou et al.

Cell Metabolism, 2011, 13 (4), pp.376 - 388. ⟨10.1016/j.cmet.2011.03.009⟩

Article dans une revue hal-02651599v1
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Pdro, a protein associated with late endosomes and lysosomes and implicated in cellular cholesterol homeostasis.

Patricia Guillaumot , Céline Luquain , Mouhannad Malek , Anne-Laure Huber , Sabine Brugière et al.

PLoS ONE, 2010, 5 (6), pp.e10977. ⟨10.1371/journal.pone.0010977⟩

Article dans une revue inserm-00763417v1

FTO Is Increased in Muscle During Type 2 Diabetes, and Its Overexpression in Myotubes Alters Insulin Signaling, Enhances Lipogenesis and ROS Production, and Induces Mitochondrial Dysfunction

A. Bravard , Etienne Lefai , E. Meugnier , S. Pesenti , Emmanuel Disse et al.

Diabetes, 2010, 60 (1), pp.258-268

Article dans une revue hal-01982013v1
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A new role for sterol regulatory element binding protein 1 transcription factors in the regulation of muscle mass and muscle cell differentiation.

Virginie Lecomte , Emmanuelle Meugnier , Vanessa Euthine , Christine Durand , Damien Freyssenet et al.

Molecular and Cellular Biology, 2010, 30 (5), pp.1182-98. ⟨10.1128/MCB.00690-09⟩

Article dans une revue inserm-00817651v1
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Downregulation of Akt/mammalian target of rapamycin pathway in skeletal muscle is associated with increased REDD1 expression in response to chronic hypoxia.

François Bertrand Favier , Frédéric Costes , Aurélia Defour , Régis Bonnefoy , Etienne Lefai et al.

American Journal of Physiology - Regulatory, Integrative and Comparative Physiology, 2010, 298 (6), pp.R1659-66. ⟨10.1152/ajpregu.00550.2009⟩

Article dans une revue inserm-00593929v1

A New Role for Sterol Regulatory Element Binding Protein 1 Transcription Factors in the Regulation of Muscle Mass and Muscle Cell Differentiation

V. Lecomte , E. Meugnier , V. Euthine , C. Durand , D. Freyssenet et al.

Molecular and Cellular Biology, 2010, 30 (5), pp.1182-1198

Article dans une revue hal-01982021v1
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The microRNA signature in response to insulin reveals its implication in the transcriptional action of insulin in human skeletal muscle and the role of a sterol regulatory element-binding protein-1c/myocyte enhancer factor 2C pathway.

Aurélie Granjon , Marie-Paule Gustin , Jennifer Rieusset , Etienne Lefai , Emmanuelle Meugnier et al.

Diabetes, 2009, 58 (11), pp.2555-64. ⟨10.2337/db09-0165⟩

Article dans une revue inserm-00808523v1

Microarray analysis of genes with impaired insulin regulation in the skeletal muscle of type 2 diabetic patients indicates the involvement of basic helix-loop-helix domain-containing, class B, 2 protein (BHLHB2)

Sophie Rome , E. Meugnier , V. Lecomte , V. Berbe , J. Besson et al.

Diabetologia, 2009, 52 (9), pp.1899-1912

Article dans une revue hal-01982031v1

The microRNA Signature in Response to Insulin Reveals Its Implication in the Transcriptional Action of Insulin in Human Skeletal Muscle and the Role of a Sterol Regulatory Element-Binding Protein-1c/Myocyte Enhancer Factor 2C Pathway

A. Granjon , M.-P. Gustin , Jennifer Rieusset , Etienne Lefai , E. Meugnier et al.

Diabetes, 2009, 58 (11), pp.2555-2564

Article dans une revue hal-01982029v1
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Microarray analyses of SREBP-1a and SREBP-1c target genes identify new regulatory pathways in muscle.

Sophie Rome , Virginie Lecomte , Emmanuelle Meugnier , Jennifer Rieusset , Cyrille Debard et al.

Physiological Genomics, 2008, 34 (3), pp.327-37. ⟨10.1152/physiolgenomics.90211.2008⟩

Article dans une revue inserm-00809732v1

Microarray analyses of SREBP-1a and SREBP-1c target genes identify new regulatory pathways in muscle

Sophie Rome , Virginie Lecomte , Emmanuelle Fouilloux-Meugnier , Jennifer Rieusset , Cyrille Debard et al.

Physiological Genomics, 2008, 34 (3), pp.327-337

Article dans une revue hal-01982035v1
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Insulin activates human sterol-regulatory-element-binding protein-1c (SREBP-1c) promoter through SRE motifs

Nicolas Dif , Vanessa Euthine , Estelle Gonnet , Martine Laville , Hubert Vidal et al.

Biochemical Journal, 2006, 400 (1), pp.179-188. ⟨10.1042/BJ20060499⟩

Article dans une revue hal-00478570v1

Regulation of SREBP-1 expression and transcriptional action on HKII and FAS genes during fasting and refeeding in rat tissues

Yvan Gosmain , Nicolas Dif , Vanessa Euthine , Emmanuelle Loizon , Jennifer J. Rieusset et al.

Journal of Lipid Research, 2005, 46 (4), pp.697-705

Article dans une revue hal-02048999v1

Expression of the splice variants of the p85alpha regulatory subunit of phosphoinositide 3-kinase in muscle and adipose tissue of healthy subjects and type 2 diabetic patients

Etienne Lefai , M. Roques , Nathalie Vega , M. Laville , Hubert Vidal

Biochemical Journal, 2001, 360, pp.117-125

Article dans une revue hal-02673828v1

Chromatin dynamics during hibernating in brown bear : Variation of H3K9 methylation

Guillaume Fourneaux , Chloé Richard , Christophe Tatout , Aline V. Probst , Cécile Coudy-Gandilhon et al.

Journée CIR3- Université Clermont Auvergne, CIR3, Nov 2024, Clermont-ferrand, France

Communication dans un congrès hal-04994384v1

Innovative approaches for an in- depth quantitative analysis of the serum proteome of brown bears

Alexandre Geffroy , Hugo Gizardin-Fredon , Jon Arnemo , Jonas Kindberg , Sarah Cianferani et al.

72nd ASMS Conference on Mass Spectrometry and Allied Topics, Jun 2024, Anaheim (CA), United States

Communication dans un congrès hal-04437952v1

Hibernation and muscle homeostasis

Etienne Lefai , Guillaume Fourneaux , Cécile Coudy-Gandilhon , Charlene Pourpe , Jonas Kindberg et al.

21èmes Journées de la SFM, Société Francaise de Myologie, Nov 2024, Clermont - Ferrand, France

Communication dans un congrès hal-04992070v1

Insights into the Transforming Growth Factor TGF-β superfamily specific modulation: unravelling the impact of hibernating bear serum in primary human muscle cells

Lydie Combaret , Richard Chloé , Fourneaux Guillaume , Geffroy Alexandre , Cueff Gwendal et al.

Physiology in Focus 2024, Jul 2024, Newcastle upon Tyne, United Kingdom

Communication dans un congrès hal-04652515v1

Effect of hibernating bear serum effect on human myotubes transcriptome: BMP signaling regulation

Chloé Richard , Guillaume Fourneaux , Alexandre Geffroy , Cécile Coudy-Gandilhon , Gwendal Cueff et al.

6e Congrès de la Société de Physiologie et Biologie Intégrative, Jul 2023, Clermont-Ferrand, France

Communication dans un congrès hal-04209952v1

Transcriptional reprogramming during hibernation: Potential role of HR in gene expression.

Guillaume Fourneaux , Cécile Coudy-Gandhilon , Charlène Pourpe , Chloé Richard , Laura Cussonneau et al.

6e Congres de Physiologie et Biologie Integrative, Société de Physiologie et de Biologie Intégrative, Jul 2023, Clermont ferrand, France

Communication dans un congrès hal-04728696v1

Hibernation in brown bears: A model for medical and space research

Etienne Lefai , Cécile Coudy-Gandilhon , Fourneaux Guillaume , Chloé Richard , Pourpe Charlène et al.

Physiology in Focus, The Scandinavian Physiological Society (SPS), the Federation of European Physiological Societies (FEPS), and the Baltic Physiological Societies., Sep 2023, Tallinn, Estonia

Communication dans un congrès hal-04728848v1

Impact of hibernating bear serum on human cells transcriptome

Guillaume Fourneaux , Cécile Coudy-Gandilhon , Laura Cussonneau , Sophie Desset , Aline Probst et al.

Journée du Centre International de Recherche 3, I-Site, I-Site UCA, Nov 2022, Clermont -Ferrand, France

Communication dans un congrès hal-04728657v1

Fighting muscle loss: lessons from hibernation in brown bear

Etienne Lefai , Cécile Coudy-Gandhilon , Laura Cussonneau , Lydie Combaret , Fabrice Bertile

SCWD 15th International Conference Cachexia, Sarcopenia and Muscle Wasting 2022, Society of Sarcopenia and Wasting Disorders, Jun 2022, Lisboa, Portugal

Communication dans un congrès hal-04728825v1

Concurrent BMP signaling maintenance and TGF- β signaling inhibition is a hallmark of natural resistance to muscle atrophy

Laura Cussonneau , Christian Boyer , Emmanuelle Meugnier , Guillemette Gauquelin-Koch , Jon Arnemo et al.

Congrès des jeunes chercheurs en Biologie de la région AURA, Jun 2021, Lyon ( virtual ), France

Communication dans un congrès hal-04209580v1

Concurrent BMP maintenance and TGFβ inhibition is a hallmark of bear resistance to muscle atrophy

Laura Cussonneau , Emeric Dubois , Jon Arnemo , Fabrice Bertile , Lydie Combaret et al.

16th International Hibernation Symposium, Aug 2021, Groningen, The Netherlands, France

Communication dans un congrès hal-04209832v1

Concurrent BMP signaling maintenance and TGF- β signaling inhibition is a hallmark of natural resistance to muscle atrophy

Laura Cussonneau , Christian Boyer , Emmanuelle Meugnier , Guillemette Gauquelin-Koch , Jon Arnemo et al.

18èmes Journées de la Société Française de Myologie, Nov 2021, Saint-Etienne, France

Communication dans un congrès hal-04209791v1

What we can learn from the bear model: lessons from hibernation

Etienne Lefai , Fabrice Bertile , Lydie Combaret

European RFMF Metabomeeting, Metabolomics and Fluxomics Network, Metabolomics Profiling Forum, European regional metabolomics networks, Jan 2020, Toulouse, France

Communication dans un congrès hal-04728774v1

Preservation of muscle mass : Lessons from hibernation

Etienne Lefai , Cécile Coudy-Gandhilon , Lydie Combaret , Fabrice Bertile

Journées Francophones de Nutrition, Société francaise de Nutrition, Nov 2020, On line, France

Communication dans un congrès hal-04728748v1

Physical inactivity and preservation of muscle mass: Lessons from Hibernation

Etienne Lefai

Nobel Conference: Bioinspirational medicine – Using nature to unlock access to opportunities in health, Sep 2019, Stockholm, Sweden

Communication dans un congrès hal-02285609v1

Integral lipidomic analysis of human skeletal muscle and visceral adipose tissue biopsy samples from lean, obese and type 2 diabetic individuals

Ursula Loizides-Mangold , Stéphanie Chanon , M. Robert , Etienne Lefai , Charna Dibner

54. Annual Meeting of the European-Association-for-the-Study-of-Diabetes (EASD), Oct 2018, berlin, Germany

Communication dans un congrès hal-02733993v1

The study of hibernation in bears to improve human health

Etienne Lefai

2018 Arctic Circle, Oct 2018, Reykjavik, Iceland

Communication dans un congrès hal-01984299v1

Adipose stem cells contribute to inflammation and insulin resistance through both TH-17 polarisation and increased pro-inflammatory cytokine secretion

A. Eljaafari , Maud Robert , Bilal Osta , Marwa Chehimi , Christine Durand et al.

49. Annual Meeting of the European-Association-for-the-Study-of-Diabetes (EASD), European Association for the Study of Diabetes (EASD). GBR., Sep 2013, Barcelone, Spain

Communication dans un congrès hal-02741210v1

Insights into the Transforming Growth Factor superfamily specific modulation: unravelling the impact of the winter-hibernating bear serum in primary human muscle cells

Lydie Combaret , Chloé Richard , Guillaume Fourneaux , Alexandre Geffroy , Gwendal Cueff et al.

Journée Scientifique CIR3, Oct 2024, Clermont- Ferrand, France

Poster de conférence hal-04737549v1

Characterization of IL-6 and GDF15 expression during the transition from pre-anorexia to anorexia in the C26 tumor-bearing mouse model

Ghita Chaouki , Laurent Parry , Laure Bindels , Céline Jousse , Isabelle Papet et al.

SCWD 15th International Conference on Cachexia, Sarcopenia and Muscle Wasting 2022, Jun 2022, Lisbonne, Portugal

Poster de conférence hal-04041599v1

Pretreatment with halofuginone attenuates adverse effects of acute inflammatory stress on mitochondrial alterations and mitophagy/biogenesis markers in liver

Ghita Chaouki , Laurent Parry , Isabelle Papet , Céline Jousse , Etienne Lefai et al.

9th proteasome and autophagy congress, 2021, Oct 2021, Clermont-Ferrand, France

Poster de conférence hal-04845987v1

Concurrent BMP Signaling Maintenance and TGF-β Signaling Inhibition Is a Hallmark of Natural Resistance to Muscle Atrophy in the Hibernating Bear

Laura Cussonneau , Emeric Dubois , Jon Arnemo , Christian Boyer , Christiane Deval et al.

9th Proteasome and Autophagy Congress, Oct 2021, Clermont-Ferrand, France

Poster de conférence hal-04209822v1

Genetic reprogramming involving a shift from TGF- β to BMP signaling for muscle mass maintenance in hibernating brown bear

Lydie Combaret , Laura Cussonneau , Christian Boyer , Christiane Deval , Emmanuelle Meugnier et al.

23eme Journée de l'Ecole Doctorale Sciences de la Vie, Santé, Agronomie et Environnement, Oct 2020, Clermont-Ferrand, France

Poster de conférence hal-04209939v1

Resolving transcription network from microarray data with constraint-based formal concept mining

Jérémy Besson , Emmanuelle Meugnier , Jean-François Boulicaut , Etienne Lefai , Hubert Vidal et al.

Ouvertes Biologie Informatique Mathématiques, JOBIM'05, Jul 2005, Lyon, France. pp.1-2, 2005

Poster de conférence hal-01614548v1