EL

Etienne Lefai

56%
Libre accès
103
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Affiliations actuelles
  • Unité de Nutrition Humaine (UNH)
  • Université Clermont Auvergne (UCA)
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Publications

Publications

Structure predictions of MuRF 1‐ UBE2 complexes identify amino acid residues governing interaction selectivity for each MuRF 1‐ E2 pair

Agnès Claustre , Mélodie Malige , Maëlys Macheton , Lydie Combaret , Etienne Lefai et al.
FEBS Journal, 2025, ⟨10.1111/febs.70017⟩
Article dans une revue hal-04993910 v1
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Reduced ATP turnover during hibernation in relaxed skeletal muscle

Cosimo de Napoli , Luisa Schmidt , Mauro Montesel , Laura Cussonneau , Samuele Sanniti et al.
Nature Communications, 2025, 16 (1), pp.80. ⟨10.1038/s41467-024-55565-4⟩
Article dans une revue hal-04892800 v1
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Alterations of lipid homeostasis in morbid obese patients are partly reversed by bariatric surgery

Flore Sinturel , Simona Chera , Marie-Claude Brulhart-Meynet , Jonathan Paz Montoya , Etienne Lefai et al.
iScience, 2024, 27 (9), pp.110820. ⟨10.1016/j.isci.2024.110820⟩
Article dans une revue hal-04753955 v1
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Involvement of Melatonin, Oxidative Stress, and Inflammation in the Protective Mechanism of the Carotid Artery over the Torpor–Arousal Cycle of Ground Squirrels

Ziwei Hao , Yuting Han , Qi Zhao , Minghui Zhu , Xiaoxuan Liu et al.
International Journal of Molecular Sciences, 2024, 25 (23), pp.12888. ⟨10.3390/ijms252312888⟩
Article dans une revue hal-04892799 v1
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Combinatorial targeting of glutamine metabolism and lysosomal-based lipid metabolism effectively suppresses glioblastoma

Yaogang Zhong , Feng Geng , Logan Mazik , Xinmin Yin , Aline Paixao Becker et al.
Cell Reports Medicine, 2024, 5 (9), pp.101706. ⟨10.1016/j.xcrm.2024.101706⟩
Article dans une revue hal-04794783 v1
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STAT3 activation of SCAP-SREBP-1 signaling upregulates fatty acid synthesis to promote tumor growth

Yunzhou Fan , Rui Zhang , Chao Wang , Meixia Pan , Feng Geng et al.
Journal of Biological Chemistry, 2024, 300 (6), pp.107351. ⟨10.1016/j.jbc.2024.107351⟩
Article dans une revue hal-04892802 v1
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Induction of ATF4-Regulated Atrogenes Is Uncoupled from Muscle Atrophy during Disuse in Halofuginone-Treated Mice and in Hibernating Brown Bears

Laura Cussonneau , Cécile Coudy-Gandilhon , Christiane Deval , Ghita Chaouki , Mehdi M. Djelloul-Mazouz et al.
International Journal of Molecular Sciences, 2023, 24 (1), pp.621. ⟨10.3390/ijms24010621⟩
Article dans une revue hal-04178468 v1
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SREBP-1 upregulates lipophagy to maintain cholesterol homeostasis in brain tumor cells

Feng Geng , Yaogang Zhong , Huali Su , Etienne Lefai , Shino Magaki et al.
Cell Reports, 2023, 42 (7), pp.112790. ⟨10.1016/j.celrep.2023.112790⟩
Article dans une revue hal-04279038 v1
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ANGPTL4 is a potential driver of HCV-induced peripheral insulin resistance

Diana Gomes , Cyril Sobolewski , Stéphanie Conzelmann , Tifany Schaer , Etienne Lefai et al.
Scientific Reports, 2023, 13 (1), pp.6767. ⟨10.1038/s41598-023-33728-5⟩
Article dans une revue hal-04176948 v1

Differential bone remodeling mechanism in hindlimb unloaded and hibernating Daurian ground squirrels: a comparison between artificial and natural disuse within the same species

Xuli Gao , Siqi Wang , Siqi Shen , Shuyao Wang , Manjiang Xie et al.
Journal of Comparative Physiology B, 2023, 193 (3), pp.329-350. ⟨10.1007/s00360-023-01482-9⟩
Article dans une revue hal-04288563 v1

Integrated transcriptomics and metabolomics reveal protective effects on heart of hibernating Daurian ground squirrels

Yingyu Yang , Ziwei Hao , Ning An , Yuting Han , Weilan Miao et al.
Journal of Cellular Physiology, 2023, ⟨10.1002/jcp.31123⟩
Article dans une revue hal-04279721 v1
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The Protective Effects on Ischemia–Reperfusion Injury Mechanisms of the Thoracic Aorta in Daurian Ground Squirrels (Spermophilus dauricus) over the Torpor–Arousal Cycle of Hibernation

Yuting Han , Weilan Miao , Ziwei Hao , Ning An , Yingyu Yang et al.
International Journal of Molecular Sciences, 2022, 23 (18), pp.10248. ⟨10.3390/ijms231810248⟩
Article dans une revue hal-03842443 v1
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Ether lipids, sphingolipids and toxic 1-deoxyceramides as hallmarks for lean and obese type 2 diabetic patients

J. T. Hannich , U. Loizides-Mangold , F. Sinturel , T. Harayama , B. Vandereycken et al.
Acta Physiologica, 2021, 232 (1), pp.e13610. ⟨10.1111/apha.13610⟩
Article dans une revue inserm-03269069 v1
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Hibernating brown bears are protected against atherogenic dyslipidemia

Sylvain Giroud , Isabelle Chery , Mathilde Arrivé , Michel Prost , Julie Zumsteg et al.
Scientific Reports, 2021, 11 (1), ⟨10.1038/s41598-021-98085-7⟩
Article dans une revue hal-03360652 v1
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Cardiomyocyte Protection by Hibernating Brown Bear Serum: Toward the Identification of New Protective Molecules Against Myocardial Infarction

Lucas Givre , Claire Crola da Silva , Jon E Swenson , Jon M Arnemo , Guillemette Gauquelin-Koch et al.
Frontiers in Cardiovascular Medicine, 2021, 8, pp.687501. ⟨10.3389/fcvm.2021.687501⟩
Article dans une revue hal-03419383 v1
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Concurrent BMP Signaling Maintenance and TGF-β Signaling Inhibition Is a Hallmark of Natural Resistance to Muscle Atrophy in the Hibernating Bear

Laura Cussonneau , Christian Boyer , Charlotte Brun , Christiane Deval , Emmanuelle Loizon et al.
Cells, 2021, 10 (8), pp.1873. ⟨10.3390/cells10081873⟩
Article dans une revue hal-03314541 v1
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MicroRNAs facilitate skeletal muscle maintenance and metabolic suppression in hibernating brown bears

Bryan E. Luu , Etienne Lefai , Sylvain Giroud , Jon E. Swenson , Blandine Chazarin et al.
Journal of Cellular Physiology, 2020, 235 (4), pp.3984-3993. ⟨10.1002/jcp.29294⟩
Article dans une revue hal-02349938 v1
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ANT2-Mediated ATP Import into Mitochondria Protects against Hypoxia Lethal Injury

Yves Gouriou , Muhammad Rizwan Alam , Zeina Harhous , Claire Crola Da Silva , Delphine Baetz et al.
Cells, 2020, Cell Signaling, 9 (12), pp.2542. ⟨10.3390/cells9122542⟩
Article dans une revue hal-03060378 v1
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Specific shifts in the endocannabinoid system in hibernating brown bears

Christian Boyer , Laura Cussonneau , Charlotte Brun , Christiane Deval , Jean-Paul Pais de Barros et al.
Frontiers in Zoology, 2020, 17, pp.35. ⟨10.1186/s12983-020-00380-y⟩
Article dans une revue hal-03054587 v1
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Hypergravity as a gravitational therapy mitigates the effects of knee osteoarthritis on the musculoskeletal system in a murine model

Benoit Dechaumet , Damien Cleret , Marie-Thérèse Linossier , Arnaud Vanden-Bossche , Stéphanie Chanon et al.
PLoS ONE, 2020, 15 (12), pp.e0243098. ⟨10.1371/journal.pone.0243098⟩
Article dans une revue hal-03152504 v1
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Limited Oxidative Stress Favors Resistance to Skeletal Muscle Atrophy in Hibernating Brown Bears (Ursus Arctos)

Blandine Chazarin , Anna Ziemianin , Alina L. Evans , Emmanuelle Meugnier , Emmanuelle Loizon et al.
Antioxidants , 2019, 8 (9), pp.334. ⟨10.3390/antiox8090334⟩
Article dans une revue hal-02274540 v1
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Metabolic reprogramming involving glycolysis in the hibernating brown bear skeletal muscle

Blandine Chazarin , Kenneth B Storey , Anna Ziemianin , Stéphanie Chanon , Marine Plumel et al.
Frontiers in Zoology, 2019, 16, pp.12. ⟨10.1186/s12983-019-0312-2⟩
Article dans une revue hal-02149735 v1
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A nutrient cocktail prevents lipid metabolism alterations induced by 20 days of daily steps reduction and fructose overfeeding: Result from a randomized study

Anthony Damiot , Rémi Demangel , John Noone , Isabelle Chery , Alexandre Zahariev et al.
Journal of Applied Physiology, 2019, 126 (1), pp.88-101. ⟨10.1152/japplphysiol.00018.2018⟩
Article dans une revue hal-01918097 v1
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In-Depth Proteome Analysis Highlights HepaRG Cells as a Versatile Cell System Surrogate for Primary Human Hepatocytes

Georg Tascher , Audrey Burban , Sandrine Camus , Marine Plumel , Stéphanie Chanon et al.
Cells, 2019, 8 (2), pp.E192. ⟨10.3390/cells8020192⟩
Article dans une revue hal-02050391 v1
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Lipidomics Reveals Seasonal Shifts in a Large-Bodied Hibernator, the Brown Bear

Sylvain Giroud , Isabelle Chery , Fabrice Bertile , Justine Bertrand-Michel , Georg Tascher et al.
Frontiers in Physiology, 2019, 10, ⟨10.3389/fphys.2019.00389⟩
Article dans une revue hal-02141629 v1
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TRPV1 variants impair intracellular Ca2+ signaling and may confer susceptibility to malignant hyperthermia

Fabien Vanden Abeele , Sabine Lotteau , Sylvie Ducreux , Charlotte Dubois , Nicole Monnier et al.
Genetics in Medicine, 2019, 21 (2), pp.441-450. ⟨10.1038/s41436-018-0066-9⟩
Article dans une revue hal-02475163 v1
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Proteolysis inhibition by hibernating bear serum leads to increased protein content in human muscle cells

Stéphanie Chanon , Blandine Chazarin , Benoit Toubhans , Christine Durand , Isabelle Chery et al.
Scientific Reports, 2018, 8 (1), pp.1-10. ⟨10.1038/s41598-018-23891-5⟩
Article dans une revue hal-01772255 v1

Disruption of Mitochondria-Associated Endoplasmic Reticulum Membrane (MAM) Integrity Contributes to Muscle Insulin Resistance in Mice and Humans

Emily Tubbs , Stéphanie Chanon , Maud Robert , Nadia Bendridi , Gabriel Bidaux et al.
Diabetes, 2018, 67 (4), pp.636-650. ⟨10.2337/db17-0316⟩
Article dans une revue hal-01847407 v1

Metabolic inflexibility is an early marker of bed-rest–induced glucose intolerance even when fat mass is stable

Floriane Rudwill , Donal O’gorman , Etienne Lefai , Isabelle Chery , Alexandre Zahariev et al.
Journal of Clinical Endocrinology and Metabolism, 2018, 103 (5), pp.1910-1920. ⟨10.1210/jc.2017-02267⟩
Article dans une revue hal-01837670 v1

Seasonal changes in eicosanoid metabolism in the brown bear

Sylvain Giroud , Alina M Evans , Isabelle Chery , Fabrice Bertile , Georg Tascher et al.
The Science of Nature Naturwissenschaften, 2018, 105 (9-10), ⟨10.1007/s00114-018-1583-8⟩
Article dans une revue hal-01907890 v1

Transcriptomic analyses reveal rhythmic and CLOCK-driven pathways in human skeletal muscle

Laurent Perrin , Ursula Loizides-Mangold , Stéphanie Chanon , Cédric Gobet , Nicolas Hulo et al.
eLife, 2018, 7, pp.30. ⟨10.7554/eLife.34114⟩
Article dans une revue hal-01847497 v1

Exercise training improves fat metabolism independent of total energy expenditure in sedentary overweight men, but does not restore lean metabolic phenotype

Etienne Lefai , Stéphane Blanc , Iman Momken , Edvina Antoun , Isabelle Chery et al.
International Journal of Obesity, 2017, 41 (12), pp.1728-1736. ⟨10.1038/ijo.2017.151⟩
Article dans une revue hal-01613860 v1

Glucose Uptake Measurement and Response to Insulin Stimulation in In Vitro Cultured Human Primary Myotubes

S. Chanon , C. Durand , A. Vieille-Marchiset , M. Robert , C. Dibner et al.
Journal of visualized experiments : JoVE, 2017, 124, ⟨10.3791/55743⟩
Article dans une revue hal-01848149 v1

Fibroblast growth factor 19 regulates skeletal muscle mass and ameliorates muscle wasting in mice

Bérengère Benoit , Emmanuelle Fouilloux-Meugnier , Martina Castelli , Stéphanie Chanon , Aurélie Vieille-Marchiset et al.
Nature Medicine, 2017, 23 (8), pp.990-996. ⟨10.1038/nm.4363⟩
Article dans une revue hal-01827292 v1

Lipidomics reveals diurnal lipid oscillations in human skeletal muscle persisting in cellular myotubes cultured in vitro

Ursula Loizides-Mangold , Laurent Perrin , Bart Vandereycken , James Betts , Jean-Philippe Walhin et al.
Proceedings of the National Academy of Sciences of the United States of America, 2017, 114 (41), pp.E8565 - E8574. ⟨10.1073/pnas.1705821114⟩
Article dans une revue hal-01827463 v1
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Transition from physical activity to inactivity increases skeletal muscle miR-148b content and triggers insulin resistance

Caroline Gastebois , Stéphanie Chanon , Sophie Rome , Christine Durand , Elise Pelascini et al.
Physiological Reports, 2016, 4 (17), pp.e12902. ⟨10.14814/phy2.12902⟩
Article dans une revue hal-01398592 v1
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Feedback Loop Regulation of SCAP/SREBP-1 by miR-29 Modulates EGFR Signaling-Driven Glioblastoma Growth

Peng Ru , Peng Hu , Feng Geng , Xiaokui Mo , Chunming Cheng et al.
Cell Reports, 2016, 16 (6), pp.1527-1535. ⟨10.1016/j.celrep.2016.07.017⟩
Article dans une revue hal-01850292 v1

Multiple microRNA regulation of lipoprotein lipase gene abolished by 3'UTR polymorphisms in a triglyceride-lowering haplotype harboring p.Ser474Ter

Cyrielle Caussy , Sybil Charriere , Aline Meirhaeghe , Jean Dallongeville , Etienne Lefai et al.
Atherosclerosis, 2016, 246, pp.280-286. ⟨10.1016/j.atherosclerosis.2016.01.010⟩
Article dans une revue hal-01986056 v1

Inhibition of SOAT1 suppresses glioblastoma growth via blocking SREBP-1-mediated lipogenesis

Feng Geng , Xiang Cheng , Xiaoning Wu , Ji Young Yoo , Chunming Cheng et al.
Clinical Cancer Research, 2016, 22 (21), pp.5337-5348. ⟨10.1158/1078-0432.CCR-15-2973⟩
Article dans une revue hal-01608883 v1

Effects of training and detraining on adiponectin plasma concentration and muscle sensitivity in lean and overweight men

Caroline Gastebois , Clément Villars , Jocelyne Drai , Emmanuelle Canet-Soulas , Stéphane Blanc et al.
European Journal of Applied Physiology, 2016, 116 (11-12), pp.2135-2144. ⟨10.1007/s00421-016-3466-z⟩
Article dans une revue hal-01382847 v1
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Human skeletal myotubes display a cell-autonomous circadian clock implicated in basal myokine secretion

L. Perrin , U. Loizides-Mangold , S. Skarupelova , P. Pulimeno , S. Chanon et al.
Molecular metabolism, 2015, 4 (11), pp.834-45. ⟨10.1016/j.molmet.2015.07.009⟩
Article dans une revue hal-01850527 v1

Adipose Tissue-Derived Stem Cells From Obese Subjects Contribute to Inflammation and Reduced Insulin Response in Adipocytes Through Differential Regulation of the Th1/Th17 Balance and Monocyte Activation

A. Eljaafari , M. Robert , M. Chehimi , S. Chanon , C. Durand et al.
Diabetes, 2015, 64 (7), pp.2477-88. ⟨10.2337/db15-0162⟩
Article dans une revue hal-01850502 v1

A TG-associated minor LPL haplotype supresses miR-29 binding on LPL 3'UTR

C. Caussy , S. Charrière , J. Dallongeville , Etienne Lefai , V. Euthine et al.
Atherosclerosis, 2015, 241 (1), pp.e12. ⟨10.1016/j.atherosclerosis.2015.04.059⟩
Article dans une revue hal-02049002 v1

Glucose-Mediated N-glycosylation of SCAP Is Essential for SREBP-1 Activation and Tumor Growth

C. Cheng , P. Ru , F. Geng , J. Liu , J. Y. Yoo et al.
Cancer Cell, 2015, 28 (5), pp.569-81. ⟨10.1016/j.ccell.2015.09.021⟩
Article dans une revue hal-01850543 v1

Myostatin Gene Inactivation Prevents Skeletal Muscle Wasting in Cancer

Yann S. Gallot , Anne-Cécile Durieux , Josiane Castells , Marine M. Desgeorges , Barbara Vernus et al.
Cancer Research, 2014, 74 (24), pp.7344-7356. ⟨10.1158/0008-5472.can-14-0057⟩
Article dans une revue hal-01837578 v1

Myotube-derived exosomal miRNAs downregulate Sirtuin1 in myoblasts during muscle cell differentiation

A. Forterre , A. Jalabert , Karim Chikh , S. Pesenti , V. Euthine et al.
Cell Cycle, 2014, 13 (1), pp.78-89. ⟨10.4161/cc.26808⟩
Article dans une revue hal-01859385 v1
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Insulin resistance is associated with MCP1-mediated macrophage accumulation in skeletal muscle in mice and humans

David Patsouris , Jingwei-Ji Cao , Guillaume Vial , Amelie Bravard , Etienne Lefai et al.
PLoS ONE, 2014, 9 (10), pp.e110653. ⟨10.1371/journal.pone.0110653⟩
Article dans une revue hal-01859365 v1
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Proteomic analysis of C2C12 myoblast and myotube exosome-like vesicles: a new paradigm for myoblast-myotube cross talk?

A. Forterre , A. Jalabert , Eric Berger , M. Baudet , Karim Chikh et al.
PLoS ONE, 2014, 9 (1), pp.e84153. ⟨10.1371/journal.pone.0084153⟩
Article dans une revue hal-01859453 v1

A socio-ecological approach promoting physical activity and limiting sedentary behavior in adolescence showed weight benefits maintained 2.5 years after intervention cessation.

Chantal Simon , Nadir Kellou , Julien Dugas , Carine Platat , Nane Copin et al.
International Journal of Obesity, 2014, 38 (7), pp.936-943. ⟨10.1038/ijo.2014.23⟩
Article dans une revue hal-00985938 v1

Effect of enforced physical inactivity induced by 60-d of bed rest on hepatic markers of NAFLD in healthy normal-weight women

Floriane Rudwill , Audrey Bergouignan , Caroline Gastebois , Guillemette Gauquelin-Koch , Etienne Lefai et al.
Liver International, 2014, 35 (6), in press. ⟨10.1111/liv.12743⟩
Article dans une revue istex hal-01101639 v1
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Exosomes participate in the alteration of muscle homeostasis during lipid-induced insulin resistance in mice

Hala Aswad , Alexis Forterre , Oscar P. B. Wiklander , Guillaume Vial , Emmanuelle Danty-Berger et al.
Diabetologia, 2014, 57 (10), pp.2155-2164. ⟨10.1007/s00125-014-3337-2⟩
Article dans une revue hal-01376852 v1

An APOA5 3' UTR variant associated with plasma triglycerides triggers APOA5 downregulation by creating a functional miR-485-5p binding site

Cyrielle Caussy , S. Charriere , C. Marcais , M. Di Filippo , A. Sassolas et al.
American Journal of Human Genetics, 2014, 94 (1), pp.129-34. ⟨10.1016/j.ajhg.2013.12.001⟩
Article dans une revue hal-01859007 v1
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Bis(monoacylglycero)phosphate accumulation in macrophages induces intracellular cholesterol redistribution, attenuates liver-X receptor/ATP-Binding cassette transporter A1/ATP-binding cassette transporter G1 pathway, and impairs cholesterol efflux.

Céline Luquain-Costaz , Etienne Lefai , Maud Arnal-Levron , Daria Markina , Shota Sakaï et al.
Arteriosclerosis, Thrombosis, and Vascular Biology, 2013, 33 (8), pp.1803-11. ⟨10.1161/ATVBAHA.113.301857⟩
Article dans une revue inserm-00844488 v1
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Phospholipase D regulates the size of skeletal muscle cells through the activation of mTOR signaling.

Rami Jaafar , Joffrey de Larichaudy , Stéphanie Chanon , Vanessa Euthine , Christine Durand et al.
Cell Communication and Signaling, 2013, 11 (1), pp.55. ⟨10.1186/1478-811X-11-55⟩
Article dans une revue inserm-00868745 v1

Adaptive Changes of the Insig1/SREBP1/SCD1 Set Point Help Adipose Tissue to Cope With Increased Storage Demands of Obesity

Stefania Carobbio , Rachel M. Hagen , Christopher J. Lelliott , Marc Slawik , Gema Medina-Gomez et al.
Diabetes, 2013, 62 (11), pp.3697 - 3708. ⟨10.2337/db12-1748⟩
Article dans une revue hal-02644218 v1

A liver Hif-2 alpha-Irs2 pathway sensitizes hepatic insulin signaling and is modulated by Vegf inhibition

Kevin Wei , Stephanie M. Piecewicz , Lisa M. Mcginnis , Cullen M. Taniguchi , Stanley J. Wiegand et al.
Nature Medicine, 2013, 19 (10), pp.1331 - +. ⟨10.1038/nm.3295⟩
Article dans une revue hal-02643867 v1

Activity energy expenditure is a major determinant of dietary fat oxidation and trafficking, but the deleterious effect of detraining is more marked than the beneficial effect of training at current recommendations.

Audrey Bergouignan , Iman Momken , Etienne Lefai , Edwina Antoun , Dale A Schoeller et al.
The American Journal of Clinical Nutrition, 2013, 98 (3), pp.648-658. ⟨10.3945/ajcn.112.057075⟩
Article dans une revue hal-00866488 v1
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SREBP-1 transcription factors regulate skeletal muscle cell size by controlling protein synthesis through myogenic regulatory factors.

Kevin Dessalle , Vanessa Euthine , Stéphanie Chanon , Joffrey de Larichaudy , Isao Fujii et al.
PLoS ONE, 2012, 7 (11), pp.e50878. ⟨10.1371/journal.pone.0050878⟩
Article dans une revue inserm-00809752 v1
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TNF-α- and tumor-induced skeletal muscle atrophy involves sphingolipid metabolism.

Joffrey de Larichaudy , Alessandra Zufferli , Filippo Serra , Andrea Isidori , Fabio Naro et al.
Skeletal Muscle, 2012, 2 (1), pp.2. ⟨10.1186/2044-5040-2-2⟩
Article dans une revue inserm-00694560 v1

Validity of combining heart rate and uniaxial acceleration to measure free-living physical activity energy expenditure in young men.

Clement Villars , Audrey Bergouignan , Julien Dugas , Edwina Antoun , Dale Alan Schoeller et al.
Journal of Applied Physiology, 2012, 113 (11), pp.1763-1771. ⟨10.1152/japplphysiol.01413.2011⟩
Article dans une revue hal-00751256 v1
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Sirtuin 1 Regulates SREBP-1c Expression in a LXR-Dependent Manner in Skeletal Muscle

Aurélia Defour , Kevin Dessalle , Andréa Castro Perez , Thomas Poyot , Josiane Castells et al.
PLoS ONE, 2012, 7 (9), pp.e43490. ⟨10.1371/journal.pone.0043490⟩
Article dans une revue hal-01779124 v1

GPIHBP1 C89F neomutation and hydrophobic C-terminal domain G175R mutation in two pedigrees with severe hyperchylomicronemia

Sybil Charriere , Noël Peretti , Sophie Bernard , Mathilde Di Filippo , Agnes Sassolas et al.
Journal of Clinical Endocrinology and Metabolism, 2011, 96 (10), ⟨10.1210/jc.2011-1444⟩
Article dans une revue hal-02652262 v1
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Phospholipase D regulates myogenic differentiation through the activation of both mTORC1 and mTORC2 complexes.

Rami Jaafar , Caroline Zeiller , Luciano Pirola , Antonio Di Grazia , Fabio Naro et al.
Journal of Biological Chemistry, 2011, 286 (25), pp.22609-21. ⟨10.1074/jbc.M110.203885⟩
Article dans une revue inserm-00817714 v1
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FTO is increased in muscle during type 2 diabetes, and its overexpression in myotubes alters insulin signaling, enhances lipogenesis and ROS production, and induces mitochondrial dysfunction.

Amélie Bravard , Etienne Lefai , Emmanuelle Fouilloux-Meugnier , Sandra Pesenti , Emmanuel Disse et al.
Diabetes, 2011, 60 (1), pp.258-68. ⟨10.2337/db10-0281⟩
Article dans une revue inserm-00809741 v1

AMPK Phosphorylates and Inhibits SREBP Activity to Attenuate Hepatic Steatosis and Atherosclerosis in Diet-Induced Insulin-Resistant Mice

Yu Li , Shanqin Xu , Maria M. Mihaylova , Bin Zheng , Xiuyun Hou et al.
Cell Metabolism, 2011, 13 (4), pp.376 - 388. ⟨10.1016/j.cmet.2011.03.009⟩
Article dans une revue hal-02651599 v1

FTO Is Increased in Muscle During Type 2 Diabetes, and Its Overexpression in Myotubes Alters Insulin Signaling, Enhances Lipogenesis and ROS Production, and Induces Mitochondrial Dysfunction

A. Bravard , Etienne Lefai , E. Meugnier , S. Pesenti , Emmanuel Disse et al.
Diabetes, 2010, 60 (1), pp.258-268
Article dans une revue hal-01982013 v1
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Pdro, a protein associated with late endosomes and lysosomes and implicated in cellular cholesterol homeostasis.

Patricia Guillaumot , Céline Luquain , Mouhannad Malek , Anne-Laure Huber , Sabine Brugière et al.
PLoS ONE, 2010, 5 (6), pp.e10977. ⟨10.1371/journal.pone.0010977⟩
Article dans une revue inserm-00763417 v1
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A new role for sterol regulatory element binding protein 1 transcription factors in the regulation of muscle mass and muscle cell differentiation.

Virginie Lecomte , Emmanuelle Meugnier , Vanessa Euthine , Christine Durand , Damien Freyssenet et al.
Molecular and Cellular Biology, 2010, 30 (5), pp.1182-98. ⟨10.1128/MCB.00690-09⟩
Article dans une revue inserm-00817651 v1
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Downregulation of Akt/mammalian target of rapamycin pathway in skeletal muscle is associated with increased REDD1 expression in response to chronic hypoxia.

François Bertrand Favier , Frédéric Costes , Aurélia Defour , Régis Bonnefoy , Etienne Lefai et al.
AJP - Regulatory, Integrative and Comparative Physiology, 2010, 298 (6), pp.R1659-66. ⟨10.1152/ajpregu.00550.2009⟩
Article dans une revue inserm-00593929 v1

A New Role for Sterol Regulatory Element Binding Protein 1 Transcription Factors in the Regulation of Muscle Mass and Muscle Cell Differentiation

V. Lecomte , E. Meugnier , V. Euthine , C. Durand , D. Freyssenet et al.
Molecular and Cellular Biology, 2010, 30 (5), pp.1182-1198
Article dans une revue hal-01982021 v1
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The microRNA signature in response to insulin reveals its implication in the transcriptional action of insulin in human skeletal muscle and the role of a sterol regulatory element-binding protein-1c/myocyte enhancer factor 2C pathway.

Aurélie Granjon , Marie-Paule Gustin , Jennifer Rieusset , Etienne Lefai , Emmanuelle Meugnier et al.
Diabetes, 2009, 58 (11), pp.2555-64. ⟨10.2337/db09-0165⟩
Article dans une revue inserm-00808523 v1

Microarray analysis of genes with impaired insulin regulation in the skeletal muscle of type 2 diabetic patients indicates the involvement of basic helix-loop-helix domain-containing, class B, 2 protein (BHLHB2)

Sophie Rome , E. Meugnier , V. Lecomte , V. Berbe , J. Besson et al.
Diabetologia, 2009, 52 (9), pp.1899-1912
Article dans une revue hal-01982031 v1

The microRNA Signature in Response to Insulin Reveals Its Implication in the Transcriptional Action of Insulin in Human Skeletal Muscle and the Role of a Sterol Regulatory Element-Binding Protein-1c/Myocyte Enhancer Factor 2C Pathway

A. Granjon , M.-P. Gustin , Jennifer Rieusset , Etienne Lefai , E. Meugnier et al.
Diabetes, 2009, 58 (11), pp.2555-2564
Article dans une revue hal-01982029 v1

Microarray analyses of SREBP-1a and SREBP-1c target genes identify new regulatory pathways in muscle

Sophie Rome , Virginie Lecomte , Emmanuelle Fouilloux-Meugnier , Jennifer Rieusset , Cyrille Debard et al.
Physiological Genomics, 2008, 34 (3), pp.327-337
Article dans une revue hal-01982035 v1
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Microarray analyses of SREBP-1a and SREBP-1c target genes identify new regulatory pathways in muscle.

Sophie Rome , Virginie Lecomte , Emmanuelle Meugnier , Jennifer Rieusset , Cyrille Debard et al.
Physiological Genomics, 2008, 34 (3), pp.327-37. ⟨10.1152/physiolgenomics.90211.2008⟩
Article dans une revue inserm-00809732 v1
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Insulin activates human sterol-regulatory-element-binding protein-1c (SREBP-1c) promoter through SRE motifs

Nicolas Dif , Vanessa Euthine , Estelle Gonnet , Martine Laville , Hubert Vidal et al.
Biochemical Journal, 2006, 400 (1), pp.179-188. ⟨10.1042/BJ20060499⟩
Article dans une revue hal-00478570 v1

Regulation of SREBP-1 expression and transcriptional action on HKII and FAS genes during fasting and refeeding in rat tissues

Yvan Gosmain , Nicolas Dif , Vanessa Euthine , Emmanuelle Loizon , Jennifer J. Rieusset et al.
Journal of Lipid Research, 2005, 46 (4), pp.697-705
Article dans une revue hal-02048999 v1

Expression of the splice variants of the p85alpha regulatory subunit of phosphoinositide 3-kinase in muscle and adipose tissue of healthy subjects and type 2 diabetic patients

Etienne Lefai , M. Roques , Nathalie Vega , M. Laville , Hubert Vidal
Biochemical Journal, 2001, 360, pp.117-125
Article dans une revue hal-02673828 v1

Chromatin dynamics during hibernating in brown bear : Variation of H3K9 methylation

Guillaume Fourneaux , Chloé Richard , Christophe Tatout , Aline V. Probst , Cécile Coudy-Gandilhon et al.
Journée CIR3- Université Clermont Auvergne, CIR3, Nov 2024, Clermont-ferrand, France
Communication dans un congrès hal-04994384 v1

Innovative approaches for an in- depth quantitative analysis of the serum proteome of brown bears

Alexandre Geffroy , Hugo Gizardin-Fredon , Jon Arnemo , Jonas Kindberg , Sarah Cianferani et al.
72nd ASMS Conference on Mass Spectrometry and Allied Topics, Jun 2024, Anaheim (CA), United States
Communication dans un congrès hal-04437952 v1

Hibernation and muscle homeostasis

Etienne Lefai , Guillaume Fourneaux , Cécile Coudy-Gandilhon , Charlene Pourpe , Jonas Kindberg et al.
21èmes Journées de la SFM, Société Francaise de Myologie, Nov 2024, Clermont - Ferrand, France
Communication dans un congrès hal-04992070 v1

Insights into the Transforming Growth Factor TGF-β superfamily specific modulation: unravelling the impact of hibernating bear serum in primary human muscle cells

Lydie Combaret , Richard Chloé , Fourneaux Guillaume , Geffroy Alexandre , Cueff Gwendal et al.
Physiology in Focus 2024, Jul 2024, Newcastle upon Tyne, United Kingdom
Communication dans un congrès hal-04652515 v1

Hibernation in brown bears: A model for medical and space research

Etienne Lefai , Cécile Coudy-Gandilhon , Fourneaux Guillaume , Chloé Richard , Pourpe Charlène et al.
Physiology in Focus, The Scandinavian Physiological Society (SPS), the Federation of European Physiological Societies (FEPS), and the Baltic Physiological Societies., Sep 2023, Tallinn, Estonia
Communication dans un congrès hal-04728848 v1

Transcriptional reprogramming during hibernation: Potential role of HR in gene expression.

Guillaume Fourneaux , Cécile Coudy-Gandhilon , Charlène Pourpe , Chloé Richard , Laura Cussonneau et al.
6e Congres de Physiologie et Biologie Integrative, Société de Physiologie et de Biologie Intégrative, Jul 2023, Clermont ferrand, France
Communication dans un congrès hal-04728696 v1

Effect of hibernating bear serum effect on human myotubes transcriptome: BMP signaling regulation

Chloé Richard , Guillaume Fourneaux , Alexandre Geffroy , Cécile Coudy-Gandilhon , Gwendal Cueff et al.
6e Congrès de la Société de Physiologie et Biologie Intégrative, Jul 2023, Clermont-Ferrand, France
Communication dans un congrès hal-04209952 v1

Impact of hibernating bear serum on human cells transcriptome

Guillaume Fourneaux , Cécile Coudy-Gandilhon , Laura Cussonneau , Sophie Desset , Aline Probst et al.
Journée du Centre International de Recherche 3, I-Site, I-Site UCA, Nov 2022, Clermont -Ferrand, France
Communication dans un congrès hal-04728657 v1

Fighting muscle loss: lessons from hibernation in brown bear

Etienne Lefai , Cécile Coudy-Gandhilon , Laura Cussonneau , Lydie Combaret , Fabrice Bertile
SCWD 15th International Conference Cachexia, Sarcopenia and Muscle Wasting 2022, Society of Sarcopenia and Wasting Disorders, Jun 2022, Lisboa, Portugal
Communication dans un congrès hal-04728825 v1

Concurrent BMP signaling maintenance and TGF- β signaling inhibition is a hallmark of natural resistance to muscle atrophy

Laura Cussonneau , Christian Boyer , Emmanuelle Meugnier , Guillemette Gauquelin-Koch , Jon Arnemo et al.
Congrès des jeunes chercheurs en Biologie de la région AURA, Jun 2021, Lyon ( virtual ), France
Communication dans un congrès hal-04209580 v1

Concurrent BMP maintenance and TGFβ inhibition is a hallmark of bear resistance to muscle atrophy

Laura Cussonneau , Emeric Dubois , Jon Arnemo , Fabrice Bertile , Lydie Combaret et al.
16th International Hibernation Symposium, Aug 2021, Groningen, The Netherlands, France
Communication dans un congrès hal-04209832 v1

Concurrent BMP signaling maintenance and TGF- β signaling inhibition is a hallmark of natural resistance to muscle atrophy

Laura Cussonneau , Christian Boyer , Emmanuelle Meugnier , Guillemette Gauquelin-Koch , Jon Arnemo et al.
18èmes Journées de la Société Française de Myologie, Nov 2021, Saint-Etienne, France
Communication dans un congrès hal-04209791 v1

What we can learn from the bear model: lessons from hibernation

Etienne Lefai , Fabrice Bertile , Lydie Combaret
European RFMF Metabomeeting, Metabolomics and Fluxomics Network, Metabolomics Profiling Forum, European regional metabolomics networks, Jan 2020, Toulouse, France
Communication dans un congrès hal-04728774 v1

Preservation of muscle mass : Lessons from hibernation

Etienne Lefai , Cécile Coudy-Gandhilon , Lydie Combaret , Fabrice Bertile
Journées Francophones de Nutrition, Société francaise de Nutrition, Nov 2020, On line, France
Communication dans un congrès hal-04728748 v1

Physical inactivity and preservation of muscle mass: Lessons from Hibernation

Etienne Lefai
Nobel Conference: Bioinspirational medicine – Using nature to unlock access to opportunities in health, Sep 2019, Stockholm, Sweden
Communication dans un congrès hal-02285609 v1

The study of hibernation in bears to improve human health

Etienne Lefai
2018 Arctic Circle, Oct 2018, Reykjavik, Iceland
Communication dans un congrès hal-01984299 v1

Integral lipidomic analysis of human skeletal muscle and visceral adipose tissue biopsy samples from lean, obese and type 2 diabetic individuals

Ursula Loizides-Mangold , Stéphanie Chanon , M. Robert , Etienne Lefai , Charna Dibner
54. Annual Meeting of the European-Association-for-the-Study-of-Diabetes (EASD), Oct 2018, berlin, Germany
Communication dans un congrès hal-02733993 v1

Adipose stem cells contribute to inflammation and insulin resistance through both TH-17 polarisation and increased pro-inflammatory cytokine secretion

A. Eljaafari , Maud Robert , Bilal Osta , Marwa Chehimi , Christine Durand et al.
49. Annual Meeting of the European-Association-for-the-Study-of-Diabetes (EASD), European Association for the Study of Diabetes (EASD). GBR., Sep 2013, Barcelone, Spain
Communication dans un congrès hal-02741210 v1

Insights into the Transforming Growth Factor superfamily specific modulation: unravelling the impact of the winter-hibernating bear serum in primary human muscle cells

Lydie Combaret , Chloé Richard , Guillaume Fourneaux , Alexandre Geffroy , Gwendal Cueff et al.
Journée Scientifique CIR3, Oct 2024, Clermont- Ferrand, France
Poster de conférence hal-04737549 v1

Characterization of IL-6 and GDF15 expression during the transition from pre-anorexia to anorexia in the C26 tumor-bearing mouse model

Ghita Chaouki , Laurent Parry , Laure Bindels , Céline Jousse , Isabelle Papet et al.
SCWD 15th International Conference on Cachexia, Sarcopenia and Muscle Wasting 2022, Jun 2022, Lisbonne, Portugal
Poster de conférence hal-04041599 v1

Pretreatment with halofuginone attenuates adverse effects of acute inflammatory stress on mitochondrial alterations and mitophagy/biogenesis markers in liver

Ghita Chaouki , Laurent Parry , Isabelle Papet , Céline Jousse , Etienne Lefai et al.
9th proteasome and autophagy congress, 2021, Oct 2021, Clermont-Ferrand, France
Poster de conférence hal-04845987 v1

Concurrent BMP Signaling Maintenance and TGF-β Signaling Inhibition Is a Hallmark of Natural Resistance to Muscle Atrophy in the Hibernating Bear

Laura Cussonneau , Emeric Dubois , Jon Arnemo , Christian Boyer , Christiane Deval et al.
9th Proteasome and Autophagy Congress, Oct 2021, Clermont-Ferrand, France
Poster de conférence hal-04209822 v1

Genetic reprogramming involving a shift from TGF- β to BMP signaling for muscle mass maintenance in hibernating brown bear

Lydie Combaret , Laura Cussonneau , Christian Boyer , Christiane Deval , Emmanuelle Meugnier et al.
23eme Journée de l'Ecole Doctorale Sciences de la Vie, Santé, Agronomie et Environnement, Oct 2020, Clermont-Ferrand, France
Poster de conférence hal-04209939 v1

Resolving transcription network from microarray data with constraint-based formal concept mining

Jérémy Besson , Emmanuelle Meugnier , Jean-François Boulicaut , Etienne Lefai , Hubert Vidal et al.
Ouvertes Biologie Informatique Mathématiques, JOBIM'05, Jul 2005, Lyon, France. pp.1-2, 2005
Poster de conférence hal-01614548 v1