Etienne THEVENOT

Responsable de l'équipe sciences des données métabolomiques pour la santé (Odiscé)
85%
Libre accès
54
Documents
Affiliations actuelles
  • Laboratoire Innovations en Spectrométrie de Masse pour la santé (LI-MS)
  • MetaboHUB-IDF
Contact

Présentation

Professional experience

Current professional status

  • Since 2020: Leader of the Metabolomics Data Sciences for Health team (CEA, Fundamental Research Division); CDI, full time devoted to research activities.
  • Since 2022: Co-leader of the multimodal integration workpackage from PROPSY (PEPR Exploratoire in precision psychiatry)
  • Since 2021: In charge of the multimodal data integration roadmap at CEA

Previous positions

  • 2005-2019: Data scientist (CEA Tech); CDI, full time devoted to research activities.
  • 2017-2021: Co-leader of the Integrative Bioinformatics task from IFB (French Institute of Bioinformatics)
  • 2013-2017: Leader of the Bioinformatics workpackage from MetaboHUB (French infrastructure in metabolomics and fluxomics)

Academic background

  • Habilitation à Diriger les Recherches en Informatique (2023). University Paris-Saclay. Ecole Doctorale “Sciences and Technologies of Information and Communication” (STIC; ED580).
  • Post-doctorate (2004-2005): Gene therapy and molecular imaging of neurodegenerative diseases (Neurodegenerative Diseases Laboratory, Molecular Imaging Research Center, MIRCen, CEA)
  • PhD in Molecular and Cellular Biology (2003). Pierre and Marie Curie University, Paris. Laboratoire de Génétique de la Neurotransmission et des Processus Neurodégénératifs (CNRS UMR 7091, Hôpital de la Pitié-Salpêtrière, Paris)
  • Diplôme d’Université (DU) in Higher Biomedical Education (2001). Paris-Sud University, Orsay.
  • Master of Molecular and Cellular Biology (1997). Pierre and Marie Curie University, Paris.
  • Master of Science and Executive Engineering (1996). MINES ParisTech graduate school, Paris.


Compétences

traitement du signal apprentissage automatique apprentissage profond sélection de variables intégration des données métabolomique

Publications

Publications

Workflow4Metabolomics (W4M): A User-Friendly Metabolomics Platform for Analysis of Mass Spectrometry and Nuclear Magnetic Resonance Data

Cédric Delporte , Marie Tremblay-Franco , Yann Guitton , Cécile Canlet , Ralf J. M. Weber et al.
Current Protocols, 2025, 5 (2), pp.e70095. ⟨10.1002/cpz1.70095⟩
Article dans une revue hal-04985097 v1

Nontargeted urine metabolomic analysis of acute intermittent porphyria reveals novel interactions between bile acids and heme metabolism: New promising biomarkers for the long‐term management of patients

Thibaud Lefebvre , Thibaut Eguether , Etienne Thévenot , Antoine Poli , Emeline Chu-Van et al.
Journal of Inherited Metabolic Disease, 2024, 48 (1), ⟨10.1002/jimd.12809⟩
Article dans une revue hal-04863195 v1

Evaluation of SP3 for antibody-free quantification of tau in CSF mimic and brain by mass spectrometry

Chloé Jacquemin , Nicolas Villain , Rita Azevedo , Susana Boluda , Etienne A Thévenot et al.
European Journal of Mass Spectrometry, 2024, 30 (1), pp.65-75. ⟨10.1177/14690667231218912⟩
Article dans une revue hal-04735796 v1
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Scaling-up metabolomics: Current state and perspectives

Ghina Hajjar , Millena Cristina Barros Santos , Justine Bertrand-Michel , Cécile Canlet , Florence A Castelli et al.
Trends in Analytical Chemistry, 2023, 167 (20), pp.117225. ⟨10.1016/j.trac.2023.117225⟩
Article dans une revue (article de synthèse) hal-04188505 v1
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Assessment of an e-nose performance for the detection of COVID-19 specific biomarkers

Christelle Ghazaly , Krystyna Biletska , Etienne Thevenot , Philippe Devillier , Emmanuel Naline et al.
Journal of Breath Research, 2023, 17 (2), pp.026006. ⟨10.1088/1752-7163/acb9b2⟩
Article dans une revue cea-04080762 v1
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PeakForest: a multi-platform digital infrastructure for interoperable metabolite spectral data and metadata management

Nils Paulhe , Cécile Canlet , Annelaure Damont , Lindsay Peyriga , Stéphanie Durand et al.
Metabolomics, 2022, 18 (6), pp.40. ⟨10.1007/s11306-022-01899-3⟩
Article dans une revue hal-03695453 v1
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ptairMS: real-time processing and analysis of PTR-TOF-MS data for biomarker discovery in exhaled breath

Camille Roquencourt , Stanislas Grassin-Delyle , Etienne A Thévenot
Bioinformatics, 2022, 38 (7), pp.1930-1937. ⟨10.1093/bioinformatics/btac031⟩
Article dans une revue cea-03598858 v1
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Metabolomics of exhaled breath in critically ill COVID-19 patients: A pilot study

Stanislas Grassin-Delyle , Camille Roquencourt , Pierre Moine , Gabriel Saffroy , Stanislas Carn et al.
EBioMedicine, 2021, 63, pp.103154. ⟨10.1016/j.ebiom.2020.103154⟩
Article dans une revue cea-03086093 v1
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Bariatric Surgery Improves the Atherogenic Profile of Circulating Methylarginines in Obese Patients: Results from a Pilot Study

Julie Poirier , Chloé Cloteau , Audrey Aguesse , Xavier Billot , Etienne Thévenot et al.
Metabolites, 2021, 11 (11), pp.759. ⟨10.3390/metabo11110759⟩
Article dans une revue hal-03653351 v1
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ProMetIS, deep phenotyping of mouse models by combined proteomics and metabolomics analysis

Alyssa Imbert , Magali Rompais , Mohammed Selloum , Florence Castelli , Emmanuelle Mouton-Barbosa et al.
Scientific Data , 2021, 8 (1), pp.311. ⟨10.1038/s41597-021-01095-3⟩
Article dans une revue pasteur-03453736 v1
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Multiplatform metabolomics for an integrative exploration of metabolic syndrome in older men

Blandine Comte , Stéphanie Monnerie , Marion Brandolini-Bunlon , Cécile Canlet , Florence Castelli et al.
EBioMedicine, 2021, 69, ⟨10.1016/j.ebiom.2021.103440⟩
Article dans une revue hal-03283772 v1
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Metabolic reprograming of LPS-stimulated human lung macrophages involves tryptophan metabolism and the aspartate-arginosuccinate shunt

Fanta Fall , Elodie Lamy , Marion Brollo , Emmanuel Naline , Natacha Lenuzza et al.
PLoS ONE, 2020, 15 (4), pp.e0230813. ⟨10.1371/journal.pone.0230813⟩
Article dans une revue inserm-02543848 v1

Nrf2-interacting nutrients and COVID-19: time for research to develop adaptation strategies

Stanislas Grassin-Delyle , Camille Roquencourt , Pierre Moine , Gabriel Saffroy , Stanislas Carn et al.
Clinical and Translational Allergy, 2020, 10 (1), pp.58. ⟨10.1016/j.ebiom.2020.103154⟩
Article dans une revue hal-04260745 v1
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Differential effects of post-weaning diet and maternal obesity on mouse liver and brain metabolomes

Sofiane Safi-Stibler , Mélanie Jouin , Etienne A Thévenot , Luc Jouneau , Alexandre Seyer et al.
Nutrients, 2020, 12 (6), pp.1572. ⟨10.3390/nu12061572⟩
Article dans une revue hal-02867469 v1

A split-range acquisition method for the non-targeted metabolomic profiling of human plasma with hydrophilic interaction chromatography - high-resolution mass spectrometry

Fanta Fall , Natacha Lenuzza , Elodie Lamy , Marion Brollo , Emmanuel Naline et al.
Journal of Chromatography B - Analytical Technologies in the Biomedical and Life Sciences, 2019, 1128, pp.121780. ⟨10.1016/j.jchromb.2019.121780⟩
Article dans une revue hal-04265136 v1
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Interoperable and scalable data analysis with microservices: applications in metabolomics

Payam Emami Khoonsari , Pablo Moreno , Sven Bergmann , Joachim Burman , Marco Capuccini et al.
Bioinformatics, 2019, 35 (19), pp.3752-3760. ⟨10.1093/bioinformatics/btz160⟩
Article dans une revue cea-04562419 v1
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A split-range acquisition method for the non-targeted metabolomic profiling of human plasma with hydrophilic interaction chromatography - high-resolution mass spectrometry

Fanta Fall , Natacha Lenuzza , Elodie Lamy , Marion Brollo , Emmanuel Naline et al.
Journal of Chromatography B - Analytical Technologies in the Biomedical and Life Sciences, 2019, 1128, pp.121780 -. ⟨10.1016/j.jchromb.2019.121780⟩
Article dans une revue hal-03488294 v1
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PhenoMeNal: processing and analysis of metabolomics data in the cloud

Kristian Peters , James Bradbury , Sven Bergmann , Marco Capuccini , Marta Cascante et al.
GigaScience, 2019, 8 (2), pp.giy149. ⟨10.1093/gigascience/giy149⟩
Article dans une revue hal-02627233 v1
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Metabolomics fingerprint of coffee species determined by untargeted-profiling study using LC-HRMS

Florence Souard , Cédric Delporte , Piet Stoffelen , Etienne Thévenot , Nausicaa Noret et al.
Food Chemistry, 2018, 245, pp.603 - 612. ⟨10.1016/j.foodchem.2017.10.022⟩
Article dans une revue cea-01765677 v1
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proFIA: A data preprocessing workflow for Flow Injection Analysis coupled to High-Resolution Mass Spectrometry

Alexis Delabrière , Ulli A Hohenester , Benoit A Colsch , Christophe A Junot , François A Fenaille et al.
Bioinformatics, 2017, 33 (23), pp.3767-3775. ⟨10.1093/bioinformatics/btx458⟩
Article dans une revue hal-01574347 v1
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The future of metabolomics in ELIXIR

M. van Rijswijk , C. Beirnaert , C. Caron , M. Cascante , V. Dominguez et al.
F1000Research, 2017, 6 (Version 2), ⟨10.12688/f1000research.12342.2⟩
Article dans une revue hal-01630635 v1
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Create, run, share, publish, and reference your LC-MS, FIA-MS, GC-MS, and NMR data analysis workflows with the Workflow4Metabolomics 3.0 Galaxy online infrastructure for metabolomics

Yann Guitton , Marie Tremblay-Franco , Gildas A Le Corguillé , Jean-Francois Martin , Mélanie Pétéra et al.
International Journal of Biochemistry and Cell Biology, 2017, 93, pp.89-101. ⟨10.1016/j.biocel.2017.07.002⟩
Article dans une revue hal-01574351 v1
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Safety and pharmacokinetics of the CIME combination of drugs and their metabolites after a single oral dosing in healthy volunteers

Natacha Lenuzza , Xavier Duval , Grégory Nicolas , Etienne Thévenot , Sylvie Job et al.
European journal of drug metabolism and pharmacokinetics, 2016, 41 (2), pp.125-138. ⟨10.1007/s13318-014-0239-0⟩
Article dans une revue hal-01868750 v1

biosigner: A New Method for the Discovery of Significant Molecular Signatures from Omics Data

Philippe Rinaudo , Samia Boudah , Christophe Junot , Etienne Thévenot
Frontiers in Molecular Biosciences, 2016, 3, ⟨10.3389/fmolb.2016.00026⟩
Article dans une revue hal-01869335 v1

Analysis of the Human Adult Urinary Metabolome Variations with Age, Body Mass Index, and Gender by Implementing a Comprehensive Workflow for Univariate and OPLS Statistical Analyses

Etienne Thévenot , Aurélie Roux , Ying Xu , Eric Ezan , Christophe Junot
Journal of Proteome Research, 2015, 14 (8), pp.3322 - 3335. ⟨10.1021/acs.jproteome.5b00354⟩
Article dans une revue cea-01865435 v1
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Workflow4Metabolomics: A collaborative research infrastructure for computational metabolomics

Franck Giacomoni , Gildas Le Corguillé , Misharl Monsoor , Marion Landi , Pierre Pericard et al.
Bioinformatics, 2015, 31 (9), pp.1493-1495. ⟨10.1093/bioinformatics/btu813⟩
Article dans une revue hal-01123263 v1

Impact of collection conditions on the metabolite content of human urine samples as analyzed by liquid chromatography coupled to mass spectrometry and nuclear magnetic resonance spectroscopy

Aurélie Roux , Etienne Thévenot , François Seguin , Marie-Françoise Olivier , Christophe Junot
Metabolomics, 2015, 11 (5), pp.1095 - 1105. ⟨10.1007/s11306-014-0764-5⟩
Article dans une revue hal-01864965 v1
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Is RE1/NRSE a Common cis -Regulatory Sequence for ChAT and VAChT Genes?

Stephanie de Gois , Leïla Houhou , Yoshio Oda , Marilys Corbex , Fabrice Pajak et al.
Journal of Biological Chemistry, 2000, 275 (47), pp.36683-36690. ⟨10.1074/jbc.M006895200⟩
Article dans une revue hal-02920246 v1
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Non-negative matrix factorization of SWATH DIA data improves global metabolite identification

Diana Karaki , Sylvain Dechaumet , Annelaure Damont , Benoit Colsch , François Fenaille et al.
EUSIPCO 2024 - 32nd European Signal Processing Conference, Aug 2024, Lyon, France
Communication dans un congrès hal-04802338 v1

Workflow4Metabolomics: an international computing infrastructure for Metabolomics

Mélanie Pétéra , Romain Dallet , Christophe Dupérier , Franck Giacomoni , Yann Guitton et al.
2019 Galaxy Community Conference (GCC2019), Jul 2019, Freibourg, Germany
Communication dans un congrès hal-02264362 v1
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Le statut métabolique maternal préconceptionnel influence le métabolisme hépatique des descendants mâles

Sofiane Safi-Stibler , Delphine Rousseau-Ralliard , Luc Jouneau , Mélanie Jouin , Claudine Junien et al.
4. Congrès de la SF-Dohad, Société Francophone-DOHaD. FRA., Nov 2018, Grenoble, France. pp.120
Communication dans un congrès hal-02736388 v1

PeakForest: a spectral reference database made from metabolomic experts for metabolomic analyses

Nils Paulhe , Pierrick Roger , Marie-Françoise Olivier , Marie Lefebvre , Christophe Duperier et al.
9. Journées scientifiques du RFMF, Réseau Francophone de Métabolomique et Fluxomique (RFMF). FRA., Jun 2015, Lille, France
Communication dans un congrès hal-02742965 v1
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MetaboHUB and RFMF : two tools at the service of metabolomics and fluxomics in France

Dominique Rolin , Floriant Bellvert , Justine Bertrand-Michel , Cécile Canlet , Richard Cole et al.
MERLION Metabolomics Workshop Singapore 2014, Nov 2014, Singapour, Singapore
Communication dans un congrès hal-02798242 v1
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ProMetIS 2.0: proteomics and metabolomics data analysis and integration, applied to the characterization of the Lat and Mx2 knock-out phenotypes

Oneeb Nasir , Alyssa Imbert , Sylvain Dechaumet , Pierrick Roger , Thomas Burger et al.
Journées Ouvertes en Biologie, Informatique, et Mathématiques (JOBIM 2024), Société Française de BioInformatique (SFBI); Institut Français de Bioinformatique (IFB); Groupement de Recherche Bioinformatique Moléculaire, Jun 2024, Toulouse, France
Communication dans un congrès hal-05035118 v1
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Technological developments and opportunities with Workflow4Metabolomics

Mélanie Pétéra , Yann Guitton , Charlotte Joly , Florence Souard , Etienne A Thévenot et al.
ISMB/ECCB 2023: The 31st Annual Intelligent Systems For Molecular Biology and the 22nd Annual European Conference on Computational Biology, Jul 2023, Lyon, France
Poster de conférence hal-04185176 v1
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Influence of FUT2/FUT3 polymorphism on human breastmilk oligosaccharide composition in the EDEN mother-child cohort

Eric Venot , Sylvain Dechaumet , Blanche Guillon , Mikaïl Berdi , Sophie Cholet et al.
Journées scientifiques du Réseau Francophone de Métabolomique et Fluxomique, May 2023, Perpignan, France
Poster de conférence hal-04351464 v1

Automatic search for chemical exposure markers in LC-HRMS metabolomic data

Dylan Saunier , Eric Venot , Sylvain Dechaumet , N Behkti , Blanche Guillon et al.
15èmes Journées Scientifiques du Réseau Francophone de Métabolomique et Fluxomique, May 2023, Perpignan, France
Poster de conférence hal-04644047 v1
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Optimization of E-nose technology for detecting nonanal: a COVID-19 biomarker in exhaled breath

Christelle Ghazaly , Krystyna Biletska , Etienne Thevenot , Philippe Devillier , Emmanuel Naline et al.
MNE-ES 2022 - 48th international conference on Micro and Nano Engineering - Eurosensors, Sep 2022, Leuven, Belgium. 2022
Poster de conférence cea-04081230 v1

Integrated Multi-omics of early breast milk constituents

Camilo Broc , Karine Adel-Patient , François Fenaille , Mikaïl Berdi , Eric Venot et al.
Intelligent Systems for Molecular Biology/European Conference on computaional biology, Jul 2021, Virtuel, France
Poster de conférence hal-03739277 v1
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Development and characterization of electronic noses for the rapid detection of COVID-19 in exhaled breath

Christelle Ghazaly , Krystyna Biletska , Etienne A Thévenot , Philippe Devillier , Emmanuel Naline et al.
10th Franco-Spanish Workshop CMC2-IBERNAM, Nov 2021, Arcachon, France.
Poster de conférence cea-03713273 v1
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Development of an automated bioinformatic workflow to assess oligosaccharide composition of early breast milk samples from LC-HRMS data

Eric Venot , Sylvain Dechaumet , Blanche Guillon , Mikaïl Berdi , Ghita Tajeddine et al.
Journées scientifiques du Réseau Francophone de Fluxomique et de Métabolomique, Nov 2021, AUSSOIS, France
Poster de conférence hal-04351512 v1
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Processing and analysis of PTR-TOF mass spectrometry data for biomarker discovery in exhaled breath

Camille Roquencourt , Stanislas Grassin Delyle , Etienne A Thévenot
ASMS 2021 - 69th ASMS Conference on Mass Spectrometry and Allied Topics, Oct 2021, Philadelphie, United States. 2021
Poster de conférence cea-04933748 v1
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INPUT OF DEEP PHENOTYPING IN THE METABOLIC SYNDROME STRATIFICATION

Stéphanie Monnerie , Mélanie Pétéra , Cécile Canlet , Florence Castelli , Benoit Colsch et al.
European RFMF Metabomeeting 2020, Jan 2020, Toulouse, France. , 262 p., 2020, Oral and Poster Abstracts European RMF Metabomeeting 2020
Poster de conférence hal-02505908 v1
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From Molecular Profiling to Precision Medicine in Metabolic Syndrome

Blandine Comte , Stéphanie Monnerie , Marion Brandolini-Bunlon , Cécile Canlet , Florence Castelli et al.
15th Annual Conference of the Metabolomics Society (Metabolomics 2019), Jun 2019, La Haye, Netherlands. 300 p., 2019
Poster de conférence hal-02293580 v1
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Pre-conceptional maternal metabolic status influences hepatic metabolome in male offspring

Sofiane Safi-Stibler , Delphine Rousseau-Ralliard , Mélanie Jouin , Luc Jouneau , Claudine Junien et al.
World congress developmental origins of health and disease (DOHAD) 2019, Oct 2019, Melbourne, Australia. , 2019
Poster de conférence hal-02408206 v1
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Optimized selection process to identify a metabolic syndrome metabolomic/lipidomic signature in older adults of the NuAge cohort

Natacha Lenuzza , Etienne Thévenot , Mélanie Pétéra , Stéphanie Monnerie , José A Morais et al.
13. Congress of the European Union Geriatric Medicine Society (EUGMS), Sep 2017, Nice, France. European Geriatric Medicine, 8, 276 p., 2017, Abstracts of the 13th International Congress of the European Union Geriatric Medicine Society –Developing Preventive Actions in Geriatrics
Poster de conférence hal-02736369 v1
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PeakForest: a spectral database and its toolbox, dedicated to the Metabolomics’ community

Nils Paulhe , Christophe Duperier , Marie Lefebvre , Pierrick Roger-Mele , Christophe Junot et al.
12. annual conference of the Metabolomics Society, Jun 2016, Dublin, United Kingdom. 2016
Poster de conférence hal-02744357 v1
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Enrichissement de la base de données spectrale peakforest en LC-MS

Sylvain Emery , Bernard Lyan , Charlotte Joly , Nils Paulhe , Franck Giacomoni et al.
10. journées scientifiques du Réseau Francophone de Métabolomique et Fluxomique, May 2016, Montpellier, France. 158 p., 2016, Livret des résumés 10JS RFMF
Poster de conférence hal-01594987 v1
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Workflow4Metabolomics: A collaborative research infrastructure for computational metabolomics

Mélanie Pétéra , Gildas Le Corguille , Marion Landi , Misharl Monsoor , Marie Tremblay-Franco et al.
JOBIM 2015 (16e édition des Journées Ouvertes en Biologie, Informatique et Mathématiques ), Jul 2015, Clermont-Ferrand, France. , 2015, JOBIM (16e édition des Journées Ouvertes en Biologie, Informatique et Mathématiques ). ⟨10.1093/bioinformatics/btu813⟩
Poster de conférence hal-01214152 v1
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New tools and workflows on W4M, the Galaxy metabolomic infrastructure

Marion Landi , Claire Lopez , Marie Tremblay-Franco , Cécile Canlet , Yann Guitton et al.
9e Journées scientifiques du RFMF, Jun 2015, Lille, France. , 2015
Poster de conférence hal-02743697 v1

PeakForest: a spectral reference database made from metabolomic experts for metabolomic analyses

Nils Paulhe , Pierrick Roger , Marie-Françoise Olivier , Marie Lefebvre , Christophe Duperier et al.
9. Journées scientifiques du RFMF, Jun 2015, Lille, France. 2015
Poster de conférence hal-02742964 v1
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Spectral Database: from data model to web interface

Nils Paulhe , Christophe Duperier , Daniel Jacob , Etienne Thévenot , Jean-Francois Martin et al.
8. Journées Scientifiques du Réseau Français de Métabolomique et Fluxomique RFMF, May 2014, Lyon, France. 2014
Poster de conférence hal-02742064 v1
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Factory and Libraries for Automatic Metabolomic Exploration : F.L.A.M.E

Marion Landi , Mélanie Pétéra , Mishari Monsoor , Gildas Le Corguillé , Christophe Duperier et al.
8. Journées Scientifiques du Réseau Français de Métabolomique et Fluxomique RFMF, May 2014, Lyon, France. 2014
Poster de conférence hal-02743239 v1
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Mass Spectrometry Imaging visualization tools developed during the Computis European project

Marie-France Robbe , Etienne A Thévenot , Markus Stoeckli , Alfons Hester , Andreas Roempp et al.
Congrès français de spectrométrie de masse et d'analyse protéomique (SMAP 2011), Sep 2011, Avignon, France. Book of abstracts of SMAP 2011
Poster de conférence cea-03086461 v1