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Fabrice BESNARD

Researcher (CRCN) INRAE
88%
Open access
32
Documents
Current affiliations
  • 577435
  • 1001887
Researcher identifiers
Contact
Web site
  • https://www.ens-lyon.fr/RDP/signalisation-hormonale-et-developpement/

Presentation

###### **Researcher (CRCN) INRAE** Date of Birth: 2/04/1983 I am working in the lab "[Plant Reproduction and Development](https://www.ens-lyon.fr/RDP/)" in the team "[Hormonal signals](https://www.ens-lyon.fr/RDP/signalisation-hormonale-et-developpement/?lang=en)". I am a plant developmental biologist interested in how the **robustness of morphogenesis and cell differentiation** is controlled across different scales during development and growth. My main working system is the **shoot apical meristem** of the model plant *Arabidopsis thaliana*, which is responsible for the generation of all above-ground part of the plant: leaves, stems, branches, flowers, fruits... My favorite developmental processes are **phyllotaxis** (the geometrical arragement of leaves and fruits around shoots) and **early organogenesis** from stem cells to produce flower or leaf (bract). I am using and developping **quantitative approaches** in genetics, genomics, confocal-microscope live imaging or macroscopic phenotyping to characterize the different factors that canalize development into reproducible shapes and patterns or, conversely, explain the origin of consistent phenotypic variations. Among these different factors, I give a particular focus on **hormonal signalling** (auxin, cytokinin, gibberellins) which are known important inter-cellular signals and is a strong expertise in my team. I am also using **forward genetics** to discover new genetic regulator without *a priori*, especially among natural genetic variations, which provides real examples of the evolution of genetic robustness in **natural populations**. I also work in strong colaboration with computer scientists, mathematicians and modelers to **develop quantitative tools, data and image analysis pipelines or modeling frameworks**. ###### **ADDRESS** Laboratoire REPRODUCTION ET DÉVELOPPEMENT DES PLANTES ENS de Lyon 46, allée d'Italie, 69364 LYON Cedex 07 FRANCE fabrice.besnard@ens-lyon.fr ###### **EDUCATION** * 2011: PhD in plant developmental biology (ENS de Lyon, France). * 2008: Master2 in cell and molecular Biology, speciality in developmental biology (Université PMC, Paris VI, France) * 2006: Agrégation des SV-STU (secondary school teacher exam, training peformed at Paris Sud-Orsay-XI & ENS Paris, France) * 2003-2005: Undergraduate studies (ENS Paris & Université PMC-Paris VI, France) * 2001-2003: Undergraduate studies (Lycée Chateaubriand, Rennes, France) ###### **POSITIONS** * 2022: Member of the CN section 23 CNRS Biologie * 2016: Recruited Scientist INRA (CRCN INRA), 2016. * 2012-2016: Postdoctoral researcher, ENS, Paris, France,

Research domains

Development Biology Morphogenesis Quantitative Methods [q-bio.QM] Plants genetics

Publications

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A Graph-Based Approach for Simultaneous Semantic and Instance Segmentation of Plant 3D Point Clouds

Katia Mirande , Christophe Godin , Marie Tisserand , Julie Charlaix , Fabrice Besnard
Frontiers in Plant Science, 2022, 13, pp.1-20. ⟨10.3389/fpls.2022.1012669⟩
Journal articles hal-03746572v2
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What shoots can teach about theories of plant form

Teva Vernoux , Fabrice Besnard , Christophe Godin
Nature Plants, 2021, 7 (6), pp.716-724. ⟨10.1038/s41477-021-00930-0⟩
Journal articles hal-03393502v1
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A broad mutational target explains a fast rate of phenotypic evolution

Fabrice Besnard , Joao Picao-Osorio , Clément Dubois , Marie-Anne Felix
Journal articles hal-03046955v1
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Necessity and Contingency in Developmental Genetic Screens: EGF, Wnt, and Semaphorin Pathways in Vulval Induction of the Nematode Oscheius tipulae

Amhed Vargas-Velazquez , Fabrice Besnard , Marie-Anne Félix
Genetics, 2019, 211 (4), pp.1315-1330. ⟨10.1534/genetics.119.301970⟩
Journal articles hal-02332248v1
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Toward universal forward genetics: using a draft genome sequence of the nematode oscheius tipulae to identify mutations affecting vulva development

Fabrice Besnard , Georgios Koutsovoulos , Sana Dieudonne , Mark Blaxter , Marie-Anne Félix
Genetics, 2017, 206 (4), pp.1747-1761. ⟨10.1534/genetics.117.203521⟩
Journal articles hal-01595198v1
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Meristem size contributes to the robustness of phyllotaxis in Arabidopsis

Benoit Landrein , Yassin Refahi , Fabrice Besnard , Nathan Hervieux , Vincent Mirabet
Journal of Experimental Botany, 2015, 66 (5), pp.1317-1324. ⟨10.1093/jxb/eru482⟩
Journal articles hal-02634017v1
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The AHP6 cytokinin signaling inhibitor mediates an auxin-cytokinin crosstalk that regulates the timing of organ initiation at the shoot apical meristem

Fabrice Besnard , Frédérique Rozier , Teva Vernoux
Plant Signaling and Behavior, 2014, 9 (4), ⟨10.4161/psb.28788⟩
Journal articles hal-01601710v1

Cytokinin signalling inhibitory fields provide robustness to phyllotaxis

Fabrice Besnard , Yassin Refahi , Valérie Morin , Benjamin Marteaux , Géraldine Brunoud
Nature, 2014, 505 (7483), pp.417-421. ⟨10.1038/nature12791⟩
Journal articles hal-00926908v1

Pattern identification and characterization reveal permutations of organs as a key genetically controlled property of post-meristematic phyllotaxis

Yann Guédon , Yassin Refahi , Fabrice Besnard , Etienne Farcot , Christophe Godin
Journal of Theoretical Biology, 2013, 338, pp.94-110. ⟨10.1016/j.jtbi.2013.07.026⟩
Journal articles hal-00859831v1
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Noise and robustness in phyllotaxis

Vincent Mirabet , Fabrice Besnard , Teva Vernoux , Arezki Boudaoud
PLoS Computational Biology, 2012, 8 (2), ⟨10.1371/journal.pcbi.1002389⟩
Journal articles hal-02648616v1

Organogenesis from stem cells in planta: multiple feedback loops integrating molecular and mechanical signals

Fabrice Besnard , Teva Vernoux , Olivier O. Hamant
Cellular and Molecular Life Sciences, 2011, 68 (17), pp.2885-2906. ⟨10.1007/s00018-011-0732-4⟩
Journal articles hal-02652230v1
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Auxin at the shoot apical meristem

Teva Vernoux , Fabrice Besnard , Jan Traas
Cold Spring Harbor Perspectives in Biology, 2010, 2 (4), pp.a001487. ⟨10.1101/cshperspect.a001487⟩
Journal articles hal-01608647v1
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Hierarchical Developmental Timeline Warping: a generic method to design realistic plant architecture models

Christophe Godin , Fabrice Besnard
10th conference on Structural-Functional Plant Models, Mar 2023, Berlin (DE), France
Conference papers hal-04392528v1

Plant precision phenotyping with ROMI

Jonathan Legrand , Marie Tisserand , Fabrice Besnard
Affordable Phenotyping Workshop, Jun 2023, Angers (France), France
Conference papers hal-04722006v1
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A Combinatorial Model of Phyllotaxis Perturbations in Arabidopsis thaliana

Yassin Refahi , Etienne Farcot , Yann Guédon , Fabrice Besnard , Teva Vernoux
22nd Annual Symposium on Combinatorial Pattern Matching, Palermo, Italy, 2011, Palermo, Italy. pp.323--335
Conference papers hal-00828852v1

A combinatorial model of phyllotaxis perturbations in [i]Arabidopsis thaliana[/i]

Yassin Refahi , Etienne Farcot , Yann Guédon , Fabrice Besnard , Teva Vernoux
22. Annual Symposium on Combinatorial Pattern Matching (CPM 2011), Jun 2011, Palerme, Italy. 480 p
Conference papers hal-01190615v1
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Analyzing perturbations in phyllotaxis of Arabidopsis thaliana

Yassin Refahi , Yann Guédon , Fabrice Besnard , Etienne Farcot , Christophe Godin
6th International Workshop on Functional-Structural Plant Models, 2010, Davis, CA, United States. pp.185-187
Conference papers hal-00831773v1
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Quelques éléments autour de la régulation du statut hydrique des plantes terrestres

Fabrice Besnard
Master. UE de Physiologie, ENS Lyon, France. 2024
Lectures hal-04721972v1
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réflexions épistémologiques d’un chercheur en biologie (généticien du développement)

Fabrice Besnard
École d'ingénieur. Cours à la carte 4GM, option F, INSA de Lyon, France. 2023
Lectures hal-04721969v1
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The nematode vulva: a gate to link genotype to phenotype

Fabrice Besnard
Master. UE Biologie du développement : nouveaux concepts et approches, ENS de Lyon, Lyon, France. 2022
Lectures hal-04721923v1