Fabrice BESNARD

Chercheur INRAE (CRCN)
82 %
Libre accès
34
Documents
Affiliations actuelles
  • Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE)
  • Reproduction et développement des plantes (RDP)
Contact

Présentation

Researcher (CRCN) INRAE

Date of Birth: 2/04/1983

I am working in the lab "Plant Reproduction and Development" in the team "Signals in Developmental Dynamics".

I am a plant developmental biologist interested in how the robustness of morphogenesis and cell differentiation is controlled across different scales during development and growth. My main working system is the shoot apical meristem of the model plant Arabidopsis thaliana, which is responsible for the generation of all above-ground part of the plant: leaves, stems, branches, flowers, fruits... My favorite developmental processes are phyllotaxis (the geometrical arragement of leaves and fruits around shoots) and early organogenesis from stem cells to produce flower or leaf (bract). I am using and developping quantitative approaches in genetics, genomics, confocal-microscope live imaging or macroscopic phenotyping to characterize the different factors that canalize development into reproducible shapes and patterns or, conversely, explain the origin of consistent phenotypic variations. Among these different factors, I give a particular focus on hormonal signalling (auxin, cytokinin, gibberellins) which are known important inter-cellular signals and is a strong expertise in my team. I am also using forward genetics to discover new genetic regulator without a priori, especially among natural genetic variations, which provides real examples of the evolution of genetic robustness in natural populations. I also work in strong colaboration with computer scientists, mathematicians and modelers to develop quantitative tools, data and image analysis pipelines or modeling frameworks.

ADDRESS

Laboratoire REPRODUCTION ET DÉVELOPPEMENT DES PLANTES ENS de Lyon 46, allée d'Italie, 69364 LYON Cedex 07 FRANCE

fabrice.besnard@ens-lyon.fr

EDUCATION
  • 2025: HDR (Habilitation à Diriger des Recherches)
  • 2011: PhD in plant developmental biology (ENS de Lyon, France).
  • 2008: Master2 in cell and molecular Biology, speciality in developmental biology (Université PMC, Paris VI, France)
  • 2006: Agrégation des SV-STU (secondary school teacher exam, training performed at Paris Sud-Orsay-XI & ENS Paris, France)
  • 2003-2005: Undergraduate studies (ENS Paris & Université PMC-Paris VI, France)
  • 2001-2003: Undergraduate studies (Lycée Chateaubriand, Rennes, France)
POSITIONS
  • 2022-2025: Member of the CN section 23 CNRS Biologie
  • 2016: Recruited Scientist INRA (CRCN INRA), 2016.
  • 2012-2016: Postdoctoral researcher, ENS, Paris, France,

Domaines de recherche

Biologie du développement Morphogenèse Bio-Informatique, Biologie Systémique [q-bio.QM] Génétique des plantes

Publications

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Publications

Natural variation in Arabidopsis uncouples leaf and flower development and reveals massive transcriptomic heterochrony

Sana Dieudonné , Ruth Kristianingsih , Stéphanie Hallet , Béline Jesson , Véronique Vidal et al.

Journal of Experimental Botany, 2026, ⟨10.1093/jxb/erag004⟩

Article dans une revue hal-05534253v1
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Recruitment of bifunctional regulator thermospermine to methylated ribosomes directs xylem fate

Donghwi Ko , Raili Ruonala , Alexandre Faille , Eva Hellmann , Hanna Help et al.

Science, 2026, 391 (6786), pp.694-699. ⟨10.1126/science.adx2867⟩

Article dans une revue hal-05508727v1
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A Graph-Based Approach for Simultaneous Semantic and Instance Segmentation of Plant 3D Point Clouds

Katia Mirande , Christophe Godin , Marie Tisserand , Julie Charlaix , Fabrice Besnard et al.

Frontiers in Plant Science, 2022, 13, pp.1-20. ⟨10.3389/fpls.2022.1012669⟩

Article dans une revue hal-03746572v2
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What shoots can teach about theories of plant form

Teva Vernoux , Fabrice Besnard , Christophe Godin

Nature Plants, 2021, 7 (6), pp.716-724. ⟨10.1038/s41477-021-00930-0⟩

Article dans une revue hal-03393502v1
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A broad mutational target explains a fast rate of phenotypic evolution

Fabrice Besnard , Joao Picao-Osorio , Clément Dubois , Marie-Anne Felix

eLife, 2020, 9, ⟨10.7554/elife.54928⟩

Article dans une revue hal-03046955v1
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Necessity and Contingency in Developmental Genetic Screens: EGF, Wnt, and Semaphorin Pathways in Vulval Induction of the Nematode Oscheius tipulae

Amhed Vargas-Velazquez , Fabrice Besnard , Marie-Anne Félix

Genetics, 2019, 211 (4), pp.1315-1330. ⟨10.1534/genetics.119.301970⟩

Article dans une revue hal-02332248v1
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Toward universal forward genetics: using a draft genome sequence of the nematode oscheius tipulae to identify mutations affecting vulva development

Fabrice Besnard , Georgios Koutsovoulos , Sana Dieudonne , Mark Blaxter , Marie-Anne Félix

Genetics, 2017, 206 (4), pp.1747-1761. ⟨10.1534/genetics.117.203521⟩

Article dans une revue hal-01595198v1
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Meristem size contributes to the robustness of phyllotaxis in Arabidopsis

Benoit Landrein , Yassin Refahi , Fabrice Besnard , Nathan Hervieux , Vincent Mirabet et al.

Journal of Experimental Botany, 2015, 66 (5), pp.1317-1324. ⟨10.1093/jxb/eru482⟩

Article dans une revue hal-02634017v1
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The AHP6 cytokinin signaling inhibitor mediates an auxin-cytokinin crosstalk that regulates the timing of organ initiation at the shoot apical meristem

Fabrice Besnard , Frédérique Rozier , Teva Vernoux

Plant Signaling and Behavior, 2014, 9 (4), ⟨10.4161/psb.28788⟩

Article dans une revue hal-01601710v1

Cytokinin signalling inhibitory fields provide robustness to phyllotaxis

Fabrice Besnard , Yassin Refahi , Valérie Morin , Benjamin Marteaux , Géraldine Brunoud et al.

Nature, 2014, 505 (7483), pp.417-421. ⟨10.1038/nature12791⟩

Article dans une revue hal-00926908v1

Pattern identification and characterization reveal permutations of organs as a key genetically controlled property of post-meristematic phyllotaxis

Yann Guédon , Yassin Refahi , Fabrice Besnard , Etienne Farcot , Christophe Godin et al.

Journal of Theoretical Biology, 2013, 338, pp.94-110. ⟨10.1016/j.jtbi.2013.07.026⟩

Article dans une revue istex hal-00859831v1
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Noise and robustness in phyllotaxis

Vincent Mirabet , Fabrice Besnard , Teva Vernoux , Arezki Boudaoud

PLoS Computational Biology, 2012, 8 (2), ⟨10.1371/journal.pcbi.1002389⟩

Article dans une revue hal-02648616v1

Organogenesis from stem cells in planta: multiple feedback loops integrating molecular and mechanical signals

Fabrice Besnard , Teva Vernoux , Olivier O. Hamant

Cellular and Molecular Life Sciences, 2011, 68 (17), pp.2885-2906. ⟨10.1007/s00018-011-0732-4⟩

Article dans une revue (article de synthèse) istex hal-02652230v1
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Auxin at the shoot apical meristem

Teva Vernoux , Fabrice Besnard , Jan Traas

Cold Spring Harbor Perspectives in Biology, 2010, 2 (4), pp.a001487. ⟨10.1101/cshperspect.a001487⟩

Article dans une revue hal-01608647v1
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Hierarchical Developmental Timeline Warping: a generic method to design realistic plant architecture models

Christophe Godin , Fabrice Besnard

10th conference on Structural-Functional Plant Models, Mar 2023, Berlin (DE), France

Communication dans un congrès hal-04392528v1

Plant precision phenotyping with ROMI

Jonathan Legrand , Marie Tisserand , Fabrice Besnard

Affordable Phenotyping Workshop, Jun 2023, Angers (France), France

Communication dans un congrès hal-04722006v1

A combinatorial model of phyllotaxis perturbations in [i]Arabidopsis thaliana[/i]

Yassin Refahi , Etienne Farcot , Yann Guédon , Fabrice Besnard , Teva Vernoux et al.

22. Annual Symposium on Combinatorial Pattern Matching (CPM 2011), Jun 2011, Palermo, Italy. 480 p

Communication dans un congrès hal-01190615v1
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A Combinatorial Model of Phyllotaxis Perturbations in Arabidopsis thaliana

Yassin Refahi , Etienne Farcot , Yann Guédon , Fabrice Besnard , Teva Vernoux et al.

22nd Annual Symposium on Combinatorial Pattern Matching, Palermo, Italy, 2011, Palermo, Italy. pp.323--335

Communication dans un congrès hal-00828852v1
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Analyzing perturbations in phyllotaxis of Arabidopsis thaliana

Yassin Refahi , Yann Guédon , Fabrice Besnard , Etienne Farcot , Christophe Godin et al.

6th International Workshop on Functional-Structural Plant Models, 2010, Davis, United States. pp.185-187

Communication dans un congrès hal-00831773v1

Biologie intégrative des organismes photosynthétiques et micro-organismes associés

Cécile Raynaud , Laurent Nussaume , Fabrice Besnard , Ugo Cenci , Daniel Clesse et al.

CNRS - Biologie intégrative des organismes photosynthétiques et micro-organismes associés (Section 23). 2025, pp.381-389

Rapport (rapport d’expertise collective) hal-05492655v1
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D6.4. Realistic model of Arabidopsis based on botanical measurements and extension to new plant species

Christophe Godin , David Colliaux , Fabrice Besnard

Commission européenne. 2022

Rapport hal-04723109v1
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D6.5 Development and assessment of a validation method for assessment of plant trait extraction from the ROMI pipeline

Fabrice Besnard , Christophe Godin

Commission européenne. 2022

Rapport hal-04723119v1
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D5.5. Report on the computer vision algorithms and their applications

Fabrice Besnard , Jonathan Legrand , Katia Mirande , Christophe Godin , Franck Hétroy-Wheeler et al.

European commission. 2022

Rapport hal-04723093v1
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D5.2 Demonstration of enhanced 3D segmentation for weeding

Fabrice Besnard , Julie Charlaix , Peter Hanappe

Commission européenne. 2020

Rapport hal-04723113v1
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D1.4 the SCANNER 3D for scientific users (Management Document)

Fabrice Besnard , Jonathan Legrand , Julie Charlaix , Nabil Ait Talib , Peter Hanappe

Commission européenne. 2020

Rapport hal-04723106v1
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D5.3 Demonstration of indoor (and outdoor), 3D reconstruction of plants

Fabrice Besnard , Julie Charlaix

Commission européenne. 2020

Rapport hal-04723117v1
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Quelques éléments autour de la régulation du statut hydrique des plantes terrestres

Fabrice Besnard

Master. UE de Physiologie, ENS Lyon, France. 2024

Cours hal-04721972v1
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réflexions épistémologiques d’un chercheur en biologie (généticien du développement)

Fabrice Besnard

École d'ingénieur. Cours à la carte 4GM, option F, INSA de Lyon, France. 2023

Cours hal-04721969v1
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The nematode vulva: a gate to link genotype to phenotype

Fabrice Besnard

Master. UE Biologie du développement : nouveaux concepts et approches, ENS de Lyon, Lyon, France. 2022

Cours hal-04721923v1