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Federica Calevro

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**Federica Calevro-Eisenlohr** ORCID: 0000-0001-7856-9617 IdHAL: federica-calevro ### **Positions** Since Sept. 2020 INRAE Research Director (DR2), BF2i Unit (INRAE – INSA Lyon) Lyon, France 2004-2020 Associate Professor, Department of Biosciences (INSA Lyon) and BF2i Unit, Lyon, France 2001-2004 Temporary Lecturer and Research Assistant, Department of Biosciences (INSA Lyon) and BF2i Unit, Lyon, France **Other appointments or responsabilities** Since Jan. 2021 INSA Lyon Directors’ Board Since Jan. 2021 Head of the BF2i Unit, Lyon, France Since Jan. 2021 Member (elected) of the scientific advisory board of the INRAE Plant Health and Environment (SPE) Division 2018-present Member of the pedagogic and orientation advisory board of the E2M2 (Evolution, Ecosystems, Microbiology &amp; Modeling) Doctoral School, University of Lyon 2017-present Co-coordinator of the French Aphid research network (BAPOA, more than 230 members in France, Belgium and Switzerland) of the INRAE SPE Division 2015-present Leader of the Trophic Symbioses team (SymT), BF2i Unit, Lyon 2015-2020 Deputy Head of the BF2i Unit, Lyon 2012-2020 Director of the Biology teaching service and member of the Executive Committe of the Department of Biosciences, INSA Lyon ### **Education and Training** 2018 Accreditation to supervise research (French HDR), INSA Lyon and University of Lyon 2000-2001 Postdoctoral Fellow, Pasteur Institute of Lille, Lille, France 1999-2000 Postdoctoral Fellow WHO, International Agency of Research on Cancer (IARC), Lyon, France 1995-1998 PhD, Biology (Cell and Developmental Biology) and Research Assistant, Department of Physiology and Biochemistry, University of Pisa, Italy 1998 Visiting Scientist, Brain Research Institute, University of Bremen, Germany 1997 Visiting Scientist, Department of Biochemistry, University of Bremen, Germany 1996 Professional Qualification (Biologist), University of Pisa, Italy, summa cum laude (50/50 cum laude) 1995 Diploma of Laurea, Molecular and Developmental Biology, University of Pisa, Italy, summa cum laude (110/110 cum laude) ### **Awards** 2000-2001 Director’s Fellow from the Pasteur Institute of Lille (Post-doc position) 1999-2000 WHO Fellowship (Post-doc position at IARC) 1998 Brain Research Institute Fellowship (visit to Bremen University, G. Roth lab) 1997 EMBO Short term Fellowship (visit to Bremen University, D. Beyersmann lab) 1997 Doctoral Mobility Fellowship from the University of Pisa (visit to Bremen University) 1995-1998 Doctoral Fellowship from the Italian National Agency for new technologies, Energy and sustainable Economic development (ENEA) 1994-1995 Pre-Graduate Fellowship from University of Pisa (1-year laboratory training) ### **Supervision of graduate students and post-doc fellows** ### Since 1995: ### 7 Postdocs ### 7 PhD students (degrees obtained in 2004, 2008, 2010, 2011, 2016, 2020, 2021) 6 have been recruited as Scientists (5 permanent positions/1 post-doc). 2 PhD projects are ongoing. ### 20 Master Students (11 M2 level and 9 M1 level). ### 3 students from University Institutes (*e.g.* IUT). ### **Teaching** ### Since 2020: INSA-Lyon, 12 h/year: Molecular genetics. ### 2001-2020: INSA-Lyon. 200-220 h/year: Anatomy, Biotechnology, Cell biology, Molecular genetics. ### 1995-1998: University of Pisa. 50 h/year: Molecular biology, Molecular toxicology, Comparative anatomy. **Fundings** 43 funded research projects: 2 International, 4 European, 2 IDEX and 6 ANR Programs, 1 France-Génomique grant, 1 Agropolis Foundation grant, 1 SPE-INRAE grant, 4 regional grants, 4 INSA Bonus, 4 INSA Invited Professorships, 4 FR BioEEnViS grants, 4 Investment Programs, 6 projects with industry (including 1 ANR). ### **Scientific Impact and other scientific output** ***Publications:*** 50 original publications, 2 invited reviews, 6 invited contributions to book chapters, 2323 citations, H-index 24, i10-index 33. ***Metabolic databases for arthropod genomes (most recent):*** 1) **DakvicCyc**, <http://arthropodacyc.cycadsys.org/DAKVI/>, *Daktulosphaira vitifoliae*, doi: 10.1186/s12915-020-00820-5 ; 2) **OruabCyc** et **AthroCyc**, <http://arthropodacyc.cycadsys.org/ORUAB/> et <http://arthropodacyc.cycadsys.org/ATHRO/>, *Orussus abietinus* et *Athalia rosae*, doi: 10.1093/gbe/**,** 3) **SitorCyc**, <http://arthropodacyc.cycadsys.org/SITOR/>, *Sitophilus oryzae*, doi: 10.1186/s12915-021-01158-2; **ArtSymbioCyc** (<http://artsymbiocyc.cycadsys.org/>) project containing the reconstruction of the integrated symbiotic metabolism between arthropods and their symbiotic or mutualistic bacteria, private. ***Tools (most recent):*** GReNaDIne: Data-Driven Approaches to Infer Gene Regulatory Networks in Python. <https://grenadine.readthedocs.io/en/latest/> ***Organization of meetings (most important*):** Joint 10th International Symbiosis Society &amp; 3rd International Conference on Holobionts (Lyon, July 2022); Annual Entomophagous meeting (2017, Lyon); Annual meetings of the Aphid French Network: 2010 and 2012 (Lyon), 2018 (Rennes) and 2022 (Nice); Colloque de Biologie de l’Insecte (16th edition, 2010, Lyon); Lyon’s International Multidisciplinary Meeting on Post-Genomics (5 editions, from 2006 to 2010, Lyon). ***Organization of practical courses:*** « Insect cell cultures », Aphid French Network (Bordeaux, October 2019); « Isolation of aphid bacteriocytes as a platform for transcriptomic analyses », HMicMac ANR grant (May 2017, Lyon); « RNAi in aphids: feeding and injection techniques », Aphid French Network (March 2008, Lyon). ***Ad hoc reviewer for Grant Organizations.*** Western University (Canada); FWO (Belgium); HRZZ (Croatian Science Foundation); CNR (Italy); ANR (France); FranceAgriMer (France); INRAE SPE research grants (France); Research Federation BioEEnViS University of Lyon (France); BQR (Bonus Qualité Recherche) INSA Lyon (France). ***Ad hoc reviewer for journals.*** Apoptosis, Arch. Insect Biochem. Physiol., BMC Biol., BMC Genomics, Cell Death Differ., Cell Rep., Current Biol., Cytom. Part A, Entomol. Exp. Appl., Environ. Microbiome, Eur. J. Entomol., FEMS Microbiol. Ecol., Insect Biochem. Mol. Biol., Insect Mol. Biol., Insect Sci., Insects, Int. J. Mol. Sci., iScience, J. Pest Sci., Microbiome, Microbiol. Spectr., Mol. Ecol., PNAS, Peptides, PlosOne, Sci. Rep., ISME J. ***Member of University selection committees (France).* INSA Lyon**: « Physiology » in 2012, « Insect symbiosis » in 2013, President of the jury « Insect Genomics » in 2015, « Symbiotic network modeling » in 2018, Coordinator of the jury « Microbes and Adaptation » in 2021, « Developmental genetics » in 2021. **University Claude Bernard Lyon1**: « Environmental and molecular microbiology » in 2012, « Plant physiology » in 2017. **University of Dijon:** « Invertebrate physiology » in 2015, **University of Nice**: « Host-Microbes interactions » in 2010 and 2012.

Publications

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Discovery of an Insect Neuroactive Helix Ring Peptide from Ant Venom

Valentine Barassé , Laurence Jouvensal , Guillaume Boy , Arnaud Billet , Steven Ascoët
Toxins, 2023, 15 (10), pp.600. ⟨10.3390/toxins15100600⟩
Article dans une revue hal-04390519v1
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Aphid BCR4 Structure and Activity Uncover a New Defensin Peptide Superfamily

Karine Loth , Nicolas Parisot , Françoise Paquet , Hugo Terrasson , Catherine Sivignon
International Journal of Molecular Sciences, 2022, 23 (20), pp.12480. ⟨10.3390/ijms232012480⟩
Article dans une revue hal-03862651v1

Evolutionary diversification of insulin-related peptides (IRPs) in aphids and spatiotemporal distribution in Acyrthosiphon pisum

C. Huygens , Mélanie Ribeiro Lopes , Karen Gaget , G. Duport , S. Peignier
Insect Biochemistry and Molecular Biology, inPress, 141, pp.103670. ⟨10.1016/j.ibmb.2021.103670⟩
Article dans une revue hal-03507324v1
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Compartmentalized into Bacteriocytes but Highly Invasive: the Puzzling Case of the Co-Obligate Symbiont Serratia symbiotica in the Aphid Periphyllus lyropictus

François Renoz , Mélanie Ribeiro Lopes , Karen Gaget , Gabrielle Duport , Marie-Christine Eloy
Microbiology Spectrum, 2022, ⟨10.1128/spectrum.00457-22⟩
Article dans une revue hal-03704068v1
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The Di-Symbiotic Systems in the Aphids Sipha maydis and Periphyllus lyropictus Provide a Contrasting Picture of Recent Co-Obligate Nutritional Endosymbiosis in Aphids

François Renoz , Jérôme Ambroise , Bertrand Bearzatto , Samir Fakhour , Nicolas Parisot
Microorganisms, 2022, 10 (7), pp.1360. ⟨10.3390/microorganisms10071360⟩
Article dans une revue hal-03738802v1
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The genome sequence of the grape phylloxera provides insights into the evolution, adaptation, and invasion routes of an iconic pest

Claude Rispe , Fabrice Legeai , Paul Nabity , Rosa Fernández , Arinder Arora
BMC Biology, 2020, 18 (1), pp.90. ⟨10.1186/s12915-020-00820-5⟩
Article dans une revue hal-02917617v1
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Evolutionary novelty in the apoptotic pathway of aphids

Mélanie Ribeiro Lopes , Nicolas Parisot , Karen Gaget , Cissy Huygens , Sergio Peignier
Proceedings of the National Academy of Sciences of the United States of America, 2020, 117 (51), pp.32545-32556. ⟨10.1073/pnas.2013847117⟩
Article dans une revue hal-03052353v1
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Bacteriocyte cell death in the pea aphid/ Buchnera symbiotic system

Pierre Simonet , Karen Gaget , Severine Balmand , Mélanie Ribeiro Lopes , Nicolas Parisot
Proceedings of the National Academy of Sciences of the United States of America, 2018, 115 (8), pp.E1819 - E1828. ⟨10.1073/pnas.1720237115⟩
Article dans une revue hal-01768487v1

A genome-wide annotation of transcription factors in the pea aphid, Acyrthosiphon pisum, and the related database, ATFdb

Nicolas Parisot , Mélanie Ribeiro Lopes , Hubert Charles , Sergio Peignier , Patrice Baa-Puyoulet
BAPOA 2023 - 13e Rencontre du Réseau Français de Biologie Adaptative des Pucerons et Organismes Associés, Nov 2023, Villeurbanne, France
Communication dans un congrès hal-04524595v1

Peptides « Bacteriocyte-specific Cysteine Rich » (BCR) : un rôle dans le contrôle de la symbiose ? Focus sur BCR4 chez le puceron du pois

Hugo Terrasson , Karine Loth , Nicolas Parisot , Isabelle Rahioui , Karen Gaget
12. Rencontre du Réseau Français de Biologie Adaptative des Pucerons et Organismes Associés (BAPOA), May 2022, Nice, France
Communication dans un congrès hal-03741305v1

Plasticity of bacteriocytes facing nutritional stresses in the pea aphid development.

Mélanie Ribeiro Lopes , Karen Gaget , François Renoz , Marie-Gabrielle Duport , Severine Balmand
12. Rencontre du Réseau Français de Biologie Adaptative des Pucerons et Organismes Associés (BAPOA), May 2022, Nice, France
Communication dans un congrès hal-03741301v1

Analysis of the inhibitor of aPoptosis (IAP) repertoire in insects reveals a complex pattern of gene losses and amplifications

Mélanie Ribeiro Lopes , Jousselin Emmanuelle , Patrice Baa-Puyoulet , C. Huygens , Karen Gaget
Incontri di diversità delle forme e degli animali, Università di Pisa, 2021, Pisa, Italy
Communication dans un congrès hal-03514196v1

Analysis of the Inhibitor of aPoptosis (IAP) repertoire in insects reveals a complex pattern of gene losses and amplifications

Mélanie Ribeiro Lopes , Nicolas Parisot , Sergio Peignier , Karen Gaget , Marie-Gabrielle Duport
Webinaires BAPOA 2021, 2021, Villeurbanne (virtual), France
Communication dans un congrès hal-03514209v1

IAP (Inhibitor-of-Apoptosis Protein) gene family expansion and functional diversification in aphids

Mélanie Ribeiro Lopes , Nicolas Parisot , Karen Gaget , Marie-Gabrielle Duport , Abdelaziz Heddi
UK-France joint Meeting Aphid Special Interest Group – BAPOA, Apr 2019, Rothamsted, United Kingdom
Communication dans un congrès hal-03512999v1

Bacteriocyte reprogramming to cope with nutritional stress in a phloem sap feeding hemipteran, the pea aphid Acyrthosiphon pisum

Nicolas Parisot , Stefano Colella , Mélanie Ribeiro Lopes , Karen Gaget , Marie-Gabrielle Duport
International Partner Days, Oct 2018, Villeurbanne (INSA-Lyon), France
Communication dans un congrès hal-03514034v1

Expansion of genes encoding Apoptosis Inhibitor Proteins (IAPs) and their role in a novel bacteriocyte cell death process in aphid symbiosis

Mélanie Ribeiro Lopes , Nicolas Parisot , Karen Gaget , Pierre Simonet , Severine Balmand
22. Evolutionary Biology Meeting, Sep 2018, Marseille, France
Communication dans un congrès hal-03509938v1

Amplification des gènes codant les protéines de la famille des IAP et leur rôle dans l'homéostasie bactériocytaire

Mélanie Ribeiro Lopes , Nicolas Parisot , Karen Gaget , Marie-Gabrielle Duport , Korneel Hens
11. Réunion du Réseau Français de Biologie Adaptative des Pucerons et Organismes Associés (BAPOA), Nov 2018, Rennes, France
Communication dans un congrès hal-03741308v1

Bacteriocyte reprogramming to cope with nutritional stress in a phloem sap feeding hemipteran, the pea aphid Acyrthosiphon pisum

Nicolas Parisot , Mélanie Ribeiro Lopes , Karen Gaget , Marie-Gabrielle Duport , Patrice Baa-Puyoulet
France-Israel PRC Meeting – The role of metabolic interactions in shaping the bacterial endosymbiotic community of Hemyptera, Nov 2018, Villeurbanne, France
Communication dans un congrès hal-03514051v1

Another way to die for bacteriocytes in the aphid/Buchnera symbiotic system

Mélanie Ribeiro Lopes , Pierre Simonet , Karen Gaget , Severine Balmand , Kurt Buhler
Journée des doctorants du département SPE, Jun 2018, Nice, France
Communication dans un congrès hal-03510629v1

A novel cell death process is involved in the elimination of bacteriocytes and their symbionts through aphid aging

Mélanie Ribeiro Lopes , Pierre Simonet , Karen Gaget , Severine Balmand , Nicolas Parisot
France-Israel PRC Meeting – The role of metabolic interactions in shaping the bacterial endosymbiotic community of Hemyptera, Nov 2018, Villeurbanne, France
Communication dans un congrès hal-03514078v1

Rôle clé du bactériocyte dans la résilience du puceron aux stress nutritionnels

Federica Calevro , Nicolas Parisot , Mélanie Ribeiro Lopes , Stefano Colella , Karen Gaget
11ème Réunion du Réseau Français de Biologie Adaptative des Pucerons et Organismes Associés (BAPOA), Nov 2018, Rennes, France
Communication dans un congrès hal-03514026v1

Effecteurs et inhibiteurs de l’apoptose chez le puceron du pois : annotation et implication dans la mort cellulaire bactériocytaire

Mélanie Ribeiro Lopes , Pierre Simonet , Karen Gaget , Marie-Gabrielle Duport , Severine Balmand
10. Réunion du Réseau Français de Biologie Adaptative des Pucerons et Organismes Associés (BAPOA), Nov 2017, Colmar, France
Communication dans un congrès hal-03506807v1

Extreme plasticity of bacteriocytes facing nutritional stresses during pea aphid development

Mélanie Ribeiro Lopes , Karen Gaget , Marie-Gabrielle Duport , Severine Balmand , Hubert Charles
10. Congress of the International Society of Symbiosis, Jul 2022, Lyon, France
Poster de conférence hal-03741327v1

Embedded into bacteriocytes, but highly invasive: the puzzling case of the co-obligate symbiont Serratia symbiotica in the aphid Periphyllus lyropictus

François Renoz , Mélanie Ribeiro Lopes , Karen Gaget , Marie-Gabrielle Duport , Marie-Christine Eloy
ELI-Day, May 2022, Louvain-la-Neuve, Belgium
Poster de conférence hal-03741341v1

Bacteriocyte-specific Cystein-Rich (BCR) peptides, a new aphid’s defensin-like family, are promising regulators of aphid symbiosis

Hugo Terrasson , Karine Loth , Nicolas Parisot , Isabelle Rahioui , Karen Gaget
10. Congress of the International Society of Symbiosis, Jul 2022, Lyon, France
Poster de conférence hal-03741331v1

The role of GPCRs in metabolism and physiology of the pea aphid, Acyrthosiphon pisum

Cissy Huygens , Mélanie Ribeiro Lopes , Karen Gaget , Marie-Gabrielle Duport , Federica Calevro
26.International Congress of Entomology, Jul 2022, Helsinki, Finland
Poster de conférence hal-03741320v1

Bacteriocytes and the interorgan communication network regulating physiology and metabolism of the pea aphid

Cissy Huygens , Mélanie Ribeiro Lopes , Karen Gaget , Marie-Gabrielle Duport , Sergio Peignier
10. Congress of the International Society of Symbiosis, Jul 2022, Lyon, France
Poster de conférence hal-03741324v1

ER stress as a major regulator of aphid bacteriocyte cell death

Karen Gaget , Mélanie Ribeiro Lopes , Marie-Gabrielle Duport , Patrick Callaerts , Nicolas Parisot
12. Rencontre du Réseau Français de Biologie Adaptative des Pucerons et Organismes Associés (BAPOA), May 2022, Nice, France
Poster de conférence hal-03741344v1

A novel cell death process eliminates both bacteriocytes and their symbionts in the pea aphid/Buchnera symbiotic system

Mélanie Ribeiro Lopes , Pierre Simonet , Karen Gaget , Severine Balmand , Nicolas Parisot
UK-France joint Meeting Aphid Special Interest Group – BAPOA, Apr 2019, Rothamsted, United Kingdom
Poster de conférence hal-03513018v1

Bacteriocyte reprogramming to cope with nutritional stress in a phloem sap feeding hemipteran, the pea aphid Acyrthosiphon pisum

Nicolas Parisot , Mélanie Ribeiro Lopes , Karen Gaget , Marie-Gabrielle Duport , Patrice Baa-Puyoulet
UK-France joint Meeting Aphid Special Interest Group – BAPOA, Apr 2019, Harpenden, United Kingdom
Poster de conférence hal-03741333v1

A novel cell death process eliminates both bacteriocytes and their symbionts in the pea aphid/Buchnera symbiotic system

Mélanie Ribeiro Lopes , Pierre Simonet , Karen Gaget , Severine Balmand , Nicolas Parisot
International Partner Days, Oct 2018, Villeurbanne (INSA-Lyon), France
Poster de conférence hal-03514067v1

A novel cell death process eliminates both bacteriocytes and their symbionts in the pea aphid/Buchnera symbiotic system

Mélanie Ribeiro Lopes , Nicolas Parisot , Karen Gaget , Patrick Callaerts , Federica Calevro
International Partner Days, Oct 2018, Lyon, France
Poster de conférence hal-03741354v1

Molecular characterization of aphid bacteriocyte cell death by RNAseq analysis

Mélanie Ribeiro Lopes , Nicolas Parisot , Karen Gaget , Patrick Callaerts , Federica Calevro
International Partner Days, Oct 2018, Lyon, France
Poster de conférence hal-03741347v1

A novel cell death process eliminates both bacteriocytes and their symbionts in the pea aphid/Buchnera symbiotic system

Mélanie Ribeiro Lopes , Pierre Simonet , Karen Gaget , Severine Balmand , Nicolas Parisot
11. European Congress of Entomology, Jul 2018, Naples, Italy
Poster de conférence hal-03509913v1

Molecular characterization of aphid bacteriocyte cell death by RNAseq analysis

Mélanie Ribeiro Lopes , Nicolas Parisot , Karen Gaget , Patrick Callaerts , Federica Calevro
11. European Congress of Entomology, Jul 2018, Naples, Italy
Poster de conférence hal-03741337v1