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Felix Rico



Felix Rico is Associate Professor in the department of Physics of Aix-Marseille University since 2013. His research is developed at the joint laboratory Aix-Marseille University, CNRS & Inserm, LAI. He studied Physics at the University Autonoma of Barcelona and received his PhD in Biophysics from the University of Barcelona. Before moving to Marseille, he was postdoc at the University of Miami Miller School of Medicine (Miami, FL) and then at the Laboratoire Physico-Chimie Curie UMR168 at Institut Curie (Paris). He has been working in force measurements with atomic force microscopy (AFM) since 2001. His research track is focused on the mechanics and adhesion properties of biological systems. He has developed various AFM based approaches to investigate the mechanical response of single molecules, membranes and cells. Recently, he adapted high speed AFM (HS-AFM) to work as a force spectroscopy tool, probing the mechanics and dynamics of single biomolecules and living cells at microsecond timescales. [Personal website](


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Monitoring of in-vitro ultrasonic stimulation of cells by numerical modeling

M. Majnooni , P. Lasaygues , V. Long , J.-C. Scimeca , D. Momier
Journal articles hal-03629272v1
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Human septins organize as octamer-based filaments and mediate actin-membrane anchoring in cells

Carla Silva Martins , Cyntia Taveneau , Gerard Castro-Linares , Mikhail Baibakov , Nicolas Buzhinsky
Journal of Cell Biology, 2022, 222 (3), pp.e202203016. ⟨10.1083/jcb.202203016⟩
Journal articles hal-03588456v2

Viscoelastic properties of suspended cells measured with shear flow deformation cytometry

Richard Gerum , Elham Mirzahossein , Mar Eroles , Jennifer Elsterer , Astrid Mainka
eLife, 2022, 11, ⟨10.7554/eLife.78823⟩
Journal articles hal-04100953v1

One-Step Calibration of AFM in Liquid

Fidan Sumbul , Nahid Hassanpour , Jorge Rodriguez-Ramos , Felix Rico
Frontiers in Physics, 2020, 8, ⟨10.3389/fphy.2020.00301⟩
Journal articles hal-03140309v1
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αvβ3 integrin expression increases elasticity in human melanoma cells

Leda Lacaria , Janina R Lange , Wolfgang H Goldmann , Felix Rico , José Luis Alonso
Biochemical and Biophysical Research Communications, inPress, ⟨10.1016/j.bbrc.2020.02.156⟩
Journal articles hal-02505792v1
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A microfluidic method generating monodispersed microparticles with controllable sizes and mechanical properties

Cheng Zhang , Romain A Grossier , Leda Lacaria , Felix Rico , Nadine A Candoni
Chemical Engineering Science, 2020, 211, pp.115322. ⟨10.1016/j.ces.2019.115322⟩
Journal articles hal-02179400v3
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Biological physics by high-speed atomic force microscopy

Ignacio Casuso , Lorena Redondo-Morata , Felix Rico
Philosophical Transactions of the Royal Society A: Mathematical, Physical and Engineering Sciences, 2020, 378 (2186), pp.20190604. ⟨10.1098/rsta.2019.0604⟩
Journal articles hal-03027169v1
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High-speed force spectroscopy: microsecond force measurements using ultrashort cantilevers

Claire Valotteau , Fidan Sumbul , Felix Rico
Biophysical Reviews, 2019, 11 (5), pp.689-699. ⟨10.1007/s12551-019-00585-4⟩
Journal articles hal-02457576v1
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Genome editing retraces the evolution of toxin resistance in the monarch butterfly

Marianthi Karageorgi , Simon Groen , Fidan Sumbul , Julianne Pelaez , Kirsten Verster
Nature, 2019, 574 (7778), pp.409-412. ⟨10.1038/s41586-019-1610-8⟩
Journal articles hal-02457580v1
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Heterogeneous and rate-dependent streptavidin–biotin unbinding revealed by high-speed force spectroscopy and atomistic simulations

Felix Rico , Andreas Russek , Laura Gonzalez , Helmut Grubmüller , Simon Scheuring
Proceedings of the National Academy of Sciences of the United States of America, 2019, 116 (14), pp.6594-6601. ⟨10.1073/pnas.1816909116⟩
Journal articles hal-02106342v1
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History, rare and multiple events of mechanical unfolding of repeat proteins

Fidan Sumbul , Arin Marchesi , Felix Rico
Journal of Chemical Physics, 2018, 148 (12), ⟨10.1063/1.5013259⟩
Journal articles hal-01792492v1

Monitoring Unfolding of Titin I27 Single and Bi Domain with High-Pressure NMR Spectroscopy

Isaline Herrada , Philippe Barthe , Marisa Vanheusden , Karine Deguillen , Léa Mammri
Biophysical Journal, 2018, 115 (2), pp.341 - 352. ⟨10.1016/j.bpj.2018.06.010⟩
Journal articles hal-01842448v1
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High-Speed Force Spectroscopy for Single Protein Unfolding

Fidan Sumbul , Arin Marchesi , Hirohide Takahashi , Simon Scheuring , Felix Rico
Methods in Molecular Biology, 2018, pp.243-264. ⟨10.1007/978-1-4939-8591-3_15⟩
Journal articles hal-01838371v1
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α-Helix Unwinding as Force Buffer in Spectrins

Hirohide Takahashi , Felix Rico , Christophe Chipot , Simon Scheuring
ACS Nano, 2018, 12 (3), pp.2719-2727. ⟨10.1021/acsnano.7b08973⟩
Journal articles hal-02106340v1
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Fifteen years of Servitude et Grandeur to the application of a biophysical technique in medicine: The tale of AFMBioMed

Jean-Luc Pellequer , Pierre Parot , Daniel Navajas , Sanjay Kumar , Vesna Svetličić
Journal of Molecular Recognition, 2018, pp.e2773. ⟨10.1002/jmr.2773⟩
Journal articles hal-02009736v1
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Standardized Nanomechanical Atomic Force Microscopy Procedure (SNAP) for Measuring Soft and Biological Samples

Hermann Schillers , Carmela Rianna , Jens Schäpe , Tomas Luque , Holger Doschke
Scientific Reports, 2017, 7 (1), pp.5117. ⟨10.1038/s41598-017-05383-0⟩
Journal articles hal-01575563v1

Mutation in the Core Structure of Desmin Intermediate Filaments Affects Myoblast Elasticity

Catherine Even , Gilles Abramovici , Florence Delort , Anna F. Rigato , Virginie Bailleux
Biophysical Journal, 2017, 113 (3), pp.627-636. ⟨10.1016/j.bpj.2017.06.020⟩
Journal articles hal-01765097v1
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High-frequency microrheology reveals cytoskeleton dynamics in living cells

A. Rigato , A. Miyagi , S. Scheuring , F. Rico
Nature Physics, 2017, 46 (1), pp.S282. ⟨10.1038/nphys4104⟩
Journal articles hal-01764684v1
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Glass-LikeMembrane Protein Diffusion in a Crowded Membrane

Ignacio Munguira , Ignacio Casuso , Hirohide Takahashi , Felix Rico , Mohamed Chami
Journal articles inserm-01285787v1
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Atomic Force Microscopy Mechanical Mapping of Micropatterned Cells Shows Adhesion Geometry-Dependent Mechanical Response on Local and Global Scales.

Annafrancesca Rigato , Felix Rico , Frédéric Eghiaian , Mathieu Piel , Simon Scheuring
ACS Nano, 2015, pp.11. ⟨10.1021/acsnano.5b00430⟩
Journal articles inserm-01159354v1
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High-speed atomic force microscopy: Imaging and force spectroscopy

Frédéric Eghiaian , Felix Rico , Adai Colom , Ignacio Casuso , Simon Scheuring
FEBS Letters, 2014, 588 pp.3631-3638. ⟨10.1016/j.febslet.2014.06.028⟩
Journal articles inserm-01360861v1
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Cannabinoid-induced actomyosin contractility shapes neuronal morphology and growth

Alexandre B. Roland , Ana Ricobaraza , Damien Carrel , Benjamin M. Jordan , Felix Rico
eLife, 2014, 3, pp.e03159. ⟨10.7554/eLife.03159.026⟩
Journal articles inserm-01356874v1
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A hybrid high-speed atomic force–optical microscope for visualizing single membrane proteins on eukaryotic cells

Adai Colom , Ignacio Casuso , Felix Rico , Simon Scheuring
Nature Communications, 2013, 4, pp.2155. ⟨10.1038/ncomms3155⟩
Journal articles inserm-01357292v1

Structural and Mechanical Heterogeneity of the Erythrocyte Membrane Reveals Hallmarks of Membrane Stability

Laura Picas , Felix Rico , Maxime Déforet , Simon Scheuring
ACS Nano, 2013, 7 (2), pp.1054-1063. ⟨10.1021/nn303824j⟩
Journal articles hal-02289092v1
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The mechanics of membrane proteins is a signature of biological function

Felix Rico , Laura Picas , Adai Colom , Nikolay Buzhynskyy , Simon Scheuring
Soft Matter, 2013, 9, pp.7866-7873. ⟨10.1039/c3sm50967b⟩
Journal articles inserm-01309103v1
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Mechanics of proteins with a focus on atomic force microscopy

Felix Rico , Annafrancesca Rigato , Laura Picas , Simon Scheuring
Journal of Nanobiotechnology, 2013, 11 (Suppl 1), pp.S3. ⟨10.1186/1477-3155-11-S1-S3⟩
Journal articles inserm-00916507v1
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Structural and Mechanical Heterogeneity of the Erythrocyte Membrane Reveals Hallmarks of Membrane Stability

Laura Picas , Felix Rico , Maxime Deforet , Simon Scheuring
ACS Nano, 2013, 7 (2), pp.1054-1063. ⟨10.1021/nn303824j⟩
Journal articles inserm-01309087v1
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High-speed force spectroscopy unfolds titin at the velocity of molecular dynamics simulations.

Felix Rico , Laura Gonzalez , Ignacio Casuso , Manel Puig-Vidal , Simon Scheuring
Science, 2013, 342 (6159), pp.741-3. ⟨10.1126/science.1239764⟩
Journal articles inserm-01309044v1
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Elongated membrane tethers, individually anchored by high affinity α4β1/VCAM-1 complexes, are the quantal units of monocyte arrests.

Calvin Chu , Emrah Celik , Felix Rico , Vincent T Moy
PLoS ONE, 2013, 8 (5), pp.e64187. ⟨10.1371/journal.pone.0064187⟩
Journal articles inserm-01363143v1
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Cellular capsules as a tool for multicellular spheroid production and for investigating the mechanics of tumor progression in vitro

Kévin Alessandri , Bibdu Ranjan Sinha , Vasily Valérïevitsch Gurchenkov , Bidisha Sinha , Tobias Reinhold Kiessling
Proceedings of the National Academy of Sciences of the United States of America, 2013, 110 (37), pp.14843-8. ⟨10.1073/pnas.1309482110⟩
Journal articles inserm-01356886v1
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Direct Measurement of the Mechanical Properties of Lipid Phases in Supported Bilayers

Laura Picas , Felix Rico , Simon Scheuring
Biophysical Journal, 2012, 102 ((1)), pp.L01-3. ⟨10.1016/j.bpj.2011.11.4001⟩
Journal articles inserm-01363280v1
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Nanomechanical Characterization of the Stiffness of Eye Lens Cells: A Pilot Study

Amela Hozic , Felix Rico , Adai Colom , Nikolay Buzhynskyy , Simon Scheuring
Investigative Ophthalmology & Visual Science, 2012, 53 ((4)), pp.2151-6. ⟨10.1167/iovs.11-8676⟩
Journal articles inserm-01363257v1

Direct Measurement of the Mechanical Properties of Lipid Phases in Supported Bilayers

Laura Picas , Felix Rico , Simon Scheuring
Biophysical Journal, 2012, 102 (1), pp.L01-L03. ⟨10.1016/j.bpj.2011.11.4001⟩
Journal articles hal-02289090v1
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High-speed atomic force microscopy: Structure and dynamics of single proteins This review comes from a themed issue on Analytical Techniques Edited

Ignacio Casuso , Felix Rico , Simon Scheuring
Current Opinion in Chemical Biology, 2011, 15 ((5)), pp.704-9. ⟨10.1016/j.cbpa.2011.05.007⟩
Journal articles inserm-01363295v1

Experimental Evidence for Membrane-Mediated Protein-Protein Interaction

Ignacio Casuso , Pierre Sens , Felix Rico , Simon Scheuring
Biophysical Journal, 2010, 99 (7), pp.L47-L49. ⟨10.1016/j.bpj.2010.07.028⟩
Journal articles hal-02896106v1

Fertilisation de la tomate en culture sous abri. Comparaison de deux modes d'apport de la fumure phospho-potassique

Richard Brun , Pierre Cornillon , J. Peyriere , F. Rico
PHM Revue Horticole, 1986, 272, pp.49-54
Journal articles hal-02724465v1
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Single-Molecule Force Spectroscopy: Experiments, Analysis, and Simulations

Fidan Sumbul , Felix Rico
Atomic Force Microscopy, Methods in Molecular Biology, pp.163-189, 2019
Book sections hal-02272098v1