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Florence Legendre

Ingénieur de Recherche
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  • 1089273
  • 7127
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Investigation of equine testis contribution to vitamin D bioactivation

Marion Rouge , Razan Elkhatib , Christelle Delalande , Juliette Cognié , Fabrice Reigner
Domestic Animal Endocrinology, 2022, 79, pp.1-9. ⟨10.1016/j.domaniend.2021.106691⟩
Journal articles hal-03478703v1
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Functionalized Nanogels with Endothelin-1 and Bradykinin Receptor Antagonist Peptides Decrease Inflammatory and Cartilage Degradation Markers of Osteoarthritis in a Horse Organoid Model of Cartilage

Aurélie Cullier , Frédéric Cassé , Seng Manivong , Romain Contentin , Florence Legendre
International Journal of Molecular Sciences, 2022, 23 (16), pp.8949. ⟨10.3390/ijms23168949⟩
Journal articles hal-03775355v1
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Tumor Suppressive Role of miR-342-5p and miR-491-5p in Human Osteosarcoma Cells

Clément Veys , Manon Jammes , Françoise Rédini , Laurent Poulain , Christophe Denoyelle
Pharmaceuticals, 2022, 15 (3), pp.362. ⟨10.3390/ph15030362⟩
Journal articles hal-03638646v1

Marine Collagen Hydrolysates Downregulate the Synthesis of Pro-Catabolic and Pro-Inflammatory Markers of Osteoarthritis and Favor Collagen Production and Metabolic Activity in Equine Articular Chondrocyte Organoids

Bastien Bourdon , Romain Contentin , Frédéric Cassé , Chloé Maspimby , Sarah Oddoux
International Journal of Molecular Sciences, 2021, 22 (2), pp.580. ⟨10.3390/ijms22020580⟩
Journal articles hal-03114578v1
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Evaluation of Allogeneic Bone-Marrow-Derived and Umbilical Cord Blood-Derived Mesenchymal Stem Cells to Prevent the Development of Osteoarthritis in An Equine Model

Lélia Bertoni , Sandrine Jacquet , Thomas Branly , Mélanie Desancé , Florence Legendre
International Journal of Molecular Sciences, 2021, 22 (5), pp.2499. ⟨10.3390/ijms22052499⟩
Journal articles hal-03193164v1
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Tumor Suppressive Role of miR-342-5p in Human Chondrosarcoma Cells and 3D Organoids

Clément Veys , Abderrahim Benmoussa , Romain Contentin , Amandine Duchemin , Emilie Brotin
International Journal of Molecular Sciences, 2021, 22 (11), pp.5590. ⟨10.3390/ijms22115590⟩
Journal articles hal-03351650v1
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An experimentally induced osteoarthritis model in horses performed on both metacarpophalangeal and metatarsophalangeal joints: Technical, clinical, imaging, biochemical, macroscopic and microscopic characterization

Lélia Bertoni , Sandrine Jacquet , Thomas Branly , Florence Legendre , Mélanie Desancé
PLoS ONE, 2020, 15 (6), pp.e0235251. ⟨10.1371/journal.pone.0235251⟩
Journal articles hal-02935223v1

Regulation of extracellular matrix synthesis by shell extracts from the marine bivalve Pecten maximus in human articular chondrocytes - Application for cartilage engineering.

Mouloud Bouyoucef , Rodolphe Rakic , Tangni Gómez-Leduc , Thomas Latire , Frédéric Marin
Marine Biotechnology, 2018, 20 (4), pp.436-450. ⟨10.1007/s10126-018-9807-7⟩
Journal articles hal-01861438v1

Chondrogenic Differentiation of Defined Equine Mesenchymal Stem Cells Derived from Umbilical Cord Blood for Use in Cartilage Repair Therapy

Mélanie Desancé , Romain Contentin , Lélia Bertoni , Tangni Gómez-Leduc , Thomas Branly
International Journal of Molecular Sciences, 2018, 19 (2), pp.537. ⟨10.3390/ijms19020537⟩
Journal articles hal-02186781v1
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Enhanced chondrogenesis of bone marrow-derived stem cells by using a combinatory cell therapy strategy with BMP-2/TGF-β1, hypoxia, and COL1A1/HtrA1 siRNAs

Florence Legendre , David Ollitrault , Tangni Gómez-Leduc , Mouloud Bouyoucef , Magalie Hervieu
Scientific Reports, 2017, 7 (1), pp.3406. ⟨10.1038/s41598-017-03579-y⟩
Journal articles hal-02285453v1
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RNA Interference and BMP-2 Stimulation Allows Equine Chondrocytes Redifferentiation in 3D-Hypoxia Cell Culture Model: Application for Matrix-Induced Autologous Chondrocyte Implantation

Rodolphe Rakic , Bastien Bourdon , Magalie Hervieu , Thomas Branly , Florence Legendre
International Journal of Molecular Sciences, 2017, 18 (9), pp.1842. ⟨10.3390/ijms18091842⟩
Journal articles hal-02186507v1

Shell extracts of the edible mussel and oyster induce an enhancement of the catabolic pathway of human skin fibroblasts, in vitro

Thomas Latire , Florence Legendre , Mouloud Bouyoucef , Frédéric Marin , Franck Carreiras
Cytotechnology, 2017, 69 (5), pp.815-829. ⟨10.1007/s10616-017-0096-1⟩
Journal articles hal-01588926v1

Hypoxia Is a Critical Parameter for Chondrogenic Differentiation of Human Umbilical Cord Blood Mesenchymal Stem Cells in Type I/III Collagen Sponges

Tangni Gómez-Leduc , Mélanie Desancé , Magalie Hervieu , Florence Legendre , David Ollitrault
International Journal of Molecular Sciences, 2017, 18 (9), pp.1933. ⟨10.3390/ijms18091933⟩
Journal articles hal-02186808v1

Characterization and use of Equine Bone Marrow Mesenchymal Stem Cells in Equine Cartilage Engineering. Study of their Hyaline Cartilage Forming Potential when Cultured under Hypoxia within a Biomaterial in the Presence of BMP-2 and TGF-ß1

Thomas Branly , Lélia Bertoni , Romain Contentin , Rodolphe Rakic , Tangni Gómez-Leduc
Stem Cell Reviews and Reports, 2017, 13 (5), pp.611-630. ⟨10.1007/s12015-017-9748-y⟩
Journal articles hal-02186824v1
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Chondrogenic commitment of human umbilical cord blood-derived mesenchymal stem cells in collagen matrices for cartilage engineering

Tangni Gómez-Leduc , Magalie Hervieu , Florence Legendre , Mouloud Bouyoucef , Nicolas Gruchy
Scientific Reports, 2016, 6 (1), pp.32786. ⟨10.1038/srep32786⟩
Journal articles inserm-02304812v1

Reduced NF- κ B activity is observed in dermal fibroblasts from black-skinned African individuals

Nicolas Bigot , Tangni Gómez-Leduc , Magalie Hervieu , Fanny Gallienne , Thierry Oddos
Experimental Dermatology, 2016, 25 (5), pp.392-394. ⟨10.1111/exd.12970⟩
Journal articles hal-02186862v1

BMP-2, hypoxia, and COL1A1/HtrA1 siRNAs favor neo-cartilage hyaline matrix formation in chondrocytes

D. Ollitrault , F. Legendre , C. Drougard , M. Briand , H. Benateau
Tissue Engineering Part C: Methods, 2015, 21 (2), pp.133-147. ⟨10.1089/ten.tec.2013.0724⟩
Journal articles hal-01804715v1
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Radiation-induced alterations of osteogenic and chondrogenic differentiation of human mesenchymal stem cells

Séverine Cruet-Hennequart , Carole Drougard , Georgina Shaw , Florence Legendre , Magali Demoor
PLoS ONE, 2015, 10 (4), pp.e0119334. ⟨10.1371/journal.pone.0119334⟩
Journal articles hal-03156371v1
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In vitro engineering of human 3D chondrosarcoma: a preclinical model relevant for investigations of radiation quality impact

Dounia Hamdi , Sofia Barbieri , François Chevalier , Jean-Emmanuel Groetz , Florence Legendre
Journal articles hal-01315021v1
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Shell Extracts from the Marine Bivalve Pecten maximus Regulate the Synthesis of Extracellular Matrix in Primary Cultured Human Skin Fibroblasts

Thomas Latire , Florence Legendre , Nicolas Bigot , Ludovic Carduner , Sabrina Kellouche
PLoS ONE, 2014, 9 (6), pp.e99931. ⟨10.1371/journal.pone.0099931⟩
Journal articles hal-01366292v1

Cartilage tissue engineering: Molecular control of chondrocyte differentiation for proper cartilage matrix reconstruction

Magali Demoor , David Ollitrault , Tangni Gómez-Leduc , Mouloud Bouyoucef , Magali Hervieu
Biochimica et Biophysica Acta (BBA) - General Subjects, 2014, 1840 (8), pp.2414-2440. ⟨10.1016/j.bbagen.2014.02.030⟩
Journal articles hal-02132064v1

Enhanced Hyaline Cartilage Matrix Synthesis in Collagen Sponge Scaffolds by Using siRNA to Stabilize Chondrocytes Phenotype Cultured with Bone Morphogenetic Protein-2 Under Hypoxia

Florence Legendre , David Ollitrault , Magalie Hervieu , Catherine Baugé , Laure Maneix
Tissue Engineering Part C: Methods, 2013, 19 (7), pp.550-567. ⟨10.1089/ten.TEC.2012.0508⟩
Journal articles hal-04199500v1

Deciphering chondrocyte behaviour in matrix-induced autologous chondrocyte implantation to undergo accurate cartilage repair with hyaline matrix

M. Demoor , L. Maneix , D. Ollitrault , F. Legendre , E. Duval
Pathologie Biologie, 2012, 60 (3), pp.199-207. ⟨10.1016/j.patbio.2012.03.003⟩
Journal articles hal-04202025v1

Sox9/Sox6 and Sp1 are involved in the insulin-like growth factor-I-mediated upregulation of human type II collagen gene expression in articular chondrocytes

Emmanuelle Renard , Benoît Porée , Christos Chadjichristos , Magdalini Kypriotou , Laure Maneix
Journal of Molecular Medicine, 2012, 90 (6), pp.649-666. ⟨10.1007/s00109-011-0842-3⟩
Journal articles hal-03838419v1

Décryptage des signalisations moléculaires contrôlant la différenciation des chondrocytes : retombées pour l’ingénierie tissulaire du cartilage : le projet ANR-TecSan PROMOCART

S. Claus , E. Aubert-Foucher , E. Perrier-Groult , C. Bougault , M.-C. Ronzière
Innovation and Research in BioMedical engineering, 2011, 32 (2), pp.95-98. ⟨10.1016/j.irbm.2011.01.015⟩
Journal articles hal-04202120v1

Interleukin-1 and Transforming Growth Factor-ß 1 as Crucial Factors in Osteoarthritic Cartilage Metabolism

Jean-Pierre Pujol , Christos Chadjichristos , Florence Legendre , Catherine Baugé , Gallic Beauchef
Connective Tissue Research, 2009, 49 (3-4), pp.293-297. ⟨10.1080/03008200802148355⟩
Journal articles hal-03838453v1

Rhein, the metabolite of diacerhein, reduces the proliferation of osteoarthritic chondrocytes and synoviocytes without inducing apoptosis

F. Legendre , A. Heuze , K. Boukerrouche , S. Leclercq , K. Boumediene
Scandinavian Journal of Rheumatology, 2009, 38 (2), pp.104-111. ⟨10.1080/03009740802421996⟩
Journal articles hal-04200456v1
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Interleukin-6 (IL-6) and/or Soluble IL-6 Receptor Down-regulation of Human Type II Collagen Gene Expression in Articular Chondrocytes Requires a Decrease of Sp1·Sp3 Ratio and of the Binding Activity of Both Factors to the COL2A1 Promoter

Benoît Porée , Magdalini Kypriotou , Christos Chadjichristos , Gallic Beauchef , Emmanuelle Renard
Journal of Biological Chemistry, 2008, 283 (8), pp.4850-4865. ⟨10.1074/jbc.M706387200⟩
Journal articles hal-03838464v1

Chondroitin sulfate modulation of matrix and inflammatory gene expression in IL-1β-stimulated chondrocytes – study in hypoxic alginate bead cultures

F. Legendre , C. Baugé , R. Roche , A.S. Saurel , J.P. Pujol
Osteoarthritis and Cartilage, 2008, 16 (1), pp.105-114. ⟨10.1016/j.joca.2007.05.020⟩
Journal articles hal-04200519v1

Evaluation of Adhesion, Proliferation, and Functional Differentiation of Dermal Fibroblasts on Glycosaminoglycan-Coated Polysulfone Membranes

Joan Attia , Florence Legendre , Quang Trong Nguyen , Catherine Baugé , Karim Boumediene
Tissue Engineering: Parts A, B, and C, 2008, 14 (10), pp.1687-1697. ⟨10.1089/ten.tea.2007.0057⟩
Journal articles hal-04200472v1

Interleukin-1β impairment of transforming growth factor β1 signaling by DOWN-REGULATION of transforming growth factor β receptor type II and up-regulation of Smad7 in human articular chondrocytes

C. Baugé , F. Legendre , S. Leclercq , J. Elissalde , J. Pujol
Arthritis and Rheumatism, 2007, 56 (9), pp.3020-3032. ⟨10.1002/art.22840⟩
Journal articles hal-04200583v1

Rhein, a diacerhein-derived metabolite, modulates the expression of matrix degrading enzymes and the cell proliferation of articular chondrocytes by inhibiting ERK and JNK-AP-1 dependent pathways.

F Legendre , P Bogdanowicz , G Martin , F Domagala , S Leclercq
Clinical and experimental rheumatology, 2007, 25 (4), pp.546-55
Journal articles hal-04200554v1

Role of interleukin 6 (IL-6)/IL-6R-induced signal tranducers and activators of transcription and mitogen-activated protein kinase/extracellular.

Florence Legendre , Patrick Bogdanowicz , Karim Boumediene , Jean-Pierre Pujol
Journal of Rheumatology, 2005, 32 (7), pp.1307-16
Journal articles hal-04201771v1

Comparative effects of 2 antioxidants, selenomethionine and epigallocatechin-gallate, on catabolic and anabolic gene expression of articular chondrocytes.

Rina Andriamanalijaona , Madeleine Kypriotou , Catherine Baugé , Emmanuelle Renard , Florence Legendre
Journal of Rheumatology, 2005, 32 (10), pp.1958-67
Journal articles hal-04200629v1
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JAK/STAT but Not ERK1/ERK2 Pathway Mediates Interleukin (IL)-6/Soluble IL-6R Down-regulation of Type II Collagen, Aggrecan Core, and Link Protein Transcription in Articular Chondrocytes

Florence Legendre , Jayesh Dudhia , Jean-Pierre Pujol , Patrick Bogdanowicz
Journal of Biological Chemistry, 2003, 278 (5), pp.2903-2912. ⟨10.1074/jbc.M110773200⟩
Journal articles hal-04201804v1

Injection intra-articulaire d’un nanogel fonctionnalisé combinant des effets mécanique et biologique rémanents contre l’arthrose chez le cheval : étude de tolérance

A. Terlinden , S. Jacquet , Aurélie Cullier , Frédéric Cassé , F. Legendre
50èmes Journées annuelles de l'AVEF, Nov 2022, Reims, France
Conference papers hal-04004349v1

Study of therapeutic potential of new functionalized nanogels against osteoarthritis by using equine cartilage organoid cultures

Aurélie Cullier , Frédéric Cassé , Florence Legendre , Romain Contentin , Seng Manivong
Journée Normande de Recherche Biomédicale, Jun 2022, Rouen, France
Conference papers hal-03722806v1

Étude de l’impact des hormones testiculaires sur le métabolisme ostéo-articulaire chez l’espèce équine

Marion Rouge , Razan Elkhatib , Christelle Delalande , Juliette Cognie , Fabrice Reigner
eCongrès International de la Société d’Andrologie de Langue Française, Société d’Andrologie de Langue Française, Jan 2021, CAEN, France
Conference papers hal-04202823v1

Functionalized Nanohydrogels decrease Inflammatory and Cartilage Degradation Biomarkers in an organoid model of horse cartilage tissue

Aurélie Cullier , Romain Contentin , Frédéric Cassé , Florence Legendre , Seng Manivong
XXIIIèmes Journées de l'Ecole Doctorale Normande de Biologie Intégrative Santé et Environnement, May 2021, CAEN, France
Conference papers hal-03229755v1

Characterization and use of equine bone marrow mesenchymal stem cells in horse cartilage engineering

Thomas Branly , Magalie Hervieu , Sandrine Jacquet , Lélia Bertoni , Tangni Gómez-Leduc
World Congress of the Osteoarthritis-Research-Society-International, Osteoarthritis Research Society International (OARSI)., Apr 2014, Paris, France. pp.1, ⟨10.1016/j.joca.2014.02.937⟩
Conference papers hal-02740012v1

Functionalized Nanogels decrease Inflammatory and Cartilage Degradation markers of Osteoarthritis in a horse organoid model of cartilage

Aurélie Cullier , Romain Contentin , Frédéric Cassé , Florence Legendre , Seng Manivong
International Cartilage Regeneration & joint Preservation Society, Apr 2022, Berlin, Germany
Conference poster hal-03653007v1

Intra-articular injection of a functionalized nanogel combining prolonged mechanical and biological effects as a treatment for osteoarthritis in the horse: a double-blinded, randomized tolerance study

A. Terlinden , S. Jacquet , Aurélie Cullier , Frédéric Cassé , Florence Legendre
Journées Normandes de la Recherche Biomédicale, Jun 2022, Rouen, France
Conference poster hal-04003400v1

Les hormones stéroïdiennes testiculaires contribuent-elles au métabolisme ostéo-articulaire chez l’espèce équine ?

Marion Rouge , Razan Elkhatib , Christelle Delalande , Juliette Cognie , Fabrice Reigner
37ème congrès de la Société Française d’Endocrinologie, Oct 2021, Le havre, France
Conference poster hal-04202815v1

Caractérisation phénotypique des chondrocytes fœtaux humains

Manon Godin , Romain Contentin , Bastien Bourdon , Florence Legendre , Arnaud Molin
10èmes Assises de Génétique Humaine et Médicale, Jan 2020, Tours, France
Conference poster hal-02436461v1

Use of therapeutic miRNAs for the treatment of chondrosarcoma

Clément Veys , Abderrahim Benmoussa , Romain Contentin , Amandine Duchemin , Emilie Brotin
3rd International Conference on the Long and the Short of Non-Coding RNAs, Jun 2019, Chania, Greece
Conference poster hal-02188430v1
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Caractérisation et différenciation des cellules souches mésenchymateuses (CSM) de la moelle osseuse équine et du sang de cordon ombilical pour des applications en ingénierie du cartilage

Thomas Branly , Mélanie Desancé , Lélia Bertoni , Romain Contentin , Rodolphe Rakic
AVEF, 2017, Paris, France
Conference poster hal-02294586v1
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Improvement of the chondrocyte-specific phenotype upon equine bone marrow mesenchymal stem cell differentiation. Influence of TGF-ß1 or TGF-ß3, associated with BMP-2 and type I collagen siRNAs

Romain Contentin , Thomas Branly , Mélanie Desancé , Miranda Concari , Thibaud Jacquel
19èmes journées françaises de Biologie de Tissus Minéralisés (SFBTM 2017), 2017, Lyon, France
Conference poster hal-02294803v1

Characterization and differentiation of equine umbilical cord blood mesenchymal stem cells for cartilage tissue engineering

Mélanie Desancé , Lélia Bertoni , Romain Contentin , Thomas Branly , Tangni Gómez-Leduc
18 èmes Journées Française de la Biologie des Tissus Minéralisés, 2016, Nancy, France
Conference poster hal-03957909v1