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François ROBIN

Francois B Robin, LBD-IBPS group leader
20
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  • 541754
  • 541771
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Presentation

François Robin is the leader of the CADMO team at the LBD-IBPS. His research group studies the dynamics of actomyosin systems during early embryonic development and morphogenesis. His group works to understand how embryos change shape during development: they are interested in the biological processes that control the mechanical properties of cells, focusing on the actomyosin cortex. Specifically, their objective is to understand how actomyosin biochemistry drives the assembly of specific structures that control cell mechanics and eventually morphogenesis. To address this question, they combine a variety of approaches from different fields, and in particular quantitative live cell imaging, genetics, optogenetics, biophysics and biochemistry. François trained in Biology at the Ecole Normale Supérieure and in Physical Chemistry at the *École Normale Supérieure de Cachan* (1999-2004). For his PhD, he joined the group of Patrick Lemaire, at the Institut de Biologie du Développement de Marseille, to study the cellular control of morphogenesis. To gain insight into the molecular and physical mechanisms that control cell shape changes, he then decided to shift model organisms and use the nematode *C. elegans*. To this end, he initiated a post-doc under the mentorship of Ed Munro, first at the University of Washington then at the University of Chicago. During this time, he developed innovative imaging techniques to visualize individual molecules at the cell surface in living embryos (single-molecule microscopy). This approach changed our perspective on how the dynamics of living systems emerge from the coordination of events at the molecular scale. In 2014, François came back to France. In 2016, he was laureate of the ATIP/Avenir program and was recruited on an open call to lead an independent research group at the Institut de Biologie Paris-Seine, in Paris. Since 2016, he is a researcher at Inserm.

Publications

Image document

Rapid assembly of a polar network architecture drives efficient actomyosin contractility

Vlad Costache , Serena Prigent Garcia , Camille N Plancke , Jing Li , Simon Begnaud et al.
Cell Reports, 2022, 39 (9), pp.110868. ⟨10.1016/j.celrep.2022.110868⟩
Journal articles hal-03874348v1

High resolution dynamic mapping of the C. elegans intestinal brush border

Aurélien Bidaud-Meynard , Flora Demouchy , Ophélie Nicolle , Anne Pacquelet , Shashi Kumar Suman et al.
Development (Cambridge, England), 2021, 148 (23), ⟨10.1242/dev.200029⟩
Journal articles hal-03426601v1
Image document

The role of mode switching in a population of actin polymers with constraints

François Robin , Anne van Gorp , Amandine Véber
Journal of Mathematical Biology, 2021, 82, ⟨10.1007/s00285-021-01551-z⟩
Journal articles hal-02301970v2

The plakin domain of C. elegans VAB-10/plectin acts as a hub in a mechanotransduction pathway to promote morphogenesis

Shashi Kumar Suman , Csaba Daday , Teresa Ferraro , Thanh Vuong-Brender , Saurabh Tak et al.
Development (Cambridge, England), 2019, 146, ⟨10.1242/dev.183780⟩
Journal articles hal-03990385v1
Image document

The plakin domain of C. elegans VAB-10/plectin acts as a hub in a mechanotransduction pathway to promote morphogenesis

Shashi Kumar Suman , Csaba Daday , Teresa Ferraro , Thanh Vuong-Brender , Saurabh Tak et al.
Development (Cambridge, England), 2019, 146, ⟨10.1242/dev.183780⟩
Journal articles hal-03035188v2
Image document

The plakin domain of C. elegans VAB-10/plectin acts as a hub in a mechanotransduction pathway to promote morphogenesis

Shashi Kumar , Csaba Daday , Teresa Ferraro , Thanh Vuong-Brender , Saurabh Tak et al.
Development (Cambridge, England), In press
Journal articles hal-02379395v1

Excitable RhoA dynamics drive pulsed contractions in the early C. elegans embryo

Jonathan Michaux , François Robin , William Mcfadden , Edwin Munro
Journal of Cell Biology, 2018, 217 (12), pp.4230-4252. ⟨10.1083/jcb.201806161⟩
Journal articles hal-03989022v1

Non-centrosomal epidermal microtubules act in parallel to LET-502/ROCK to promote C. elegans elongation

Shahoe Wang , Julien Pontabry , Ambre Bender , Francois Robin , Vincent Hyenne et al.
Development (Cambridge, England), 2016, 143 (1), pp.160-173. ⟨10.1242/dev.126615⟩
Journal articles hal-01538537v1

Non-centrosomal epidermal microtubules act in parallel to LET-502/ROCK to promote C. elegans elongation

Sophie Quintin , Shahoe Wang , Julien Pontabry , Ambre Bender , François Robin et al.
Development (Cambridge, England), 2016, ⟨10.1242/dev.126615⟩
Journal articles hal-03989013v1

Single-molecule analysis of cell surface dynamics in Caenorhabditis elegans embryos

François Robin , William Mcfadden , Baixue Yao , Edwin Munro
Nature Methods, 2014, 11 (6), pp.677-682. ⟨10.1038/nmeth.2928⟩
Journal articles hal-03988994v1

Imaging of Fixed Ciona Embryos for Creating 3D Digital Replicas

François Robin , Delphine Dauga , Olivier Tassy , Daniel Sobral , Fabrice Daian et al.
Cold Spring Harbor protocols, 2011, 2011 (10), pdb.prot065854. ⟨10.1101/pdb.prot065854⟩
Journal articles hal-03988986v1

Creating 3D Digital Replicas of Ascidian Embryos from Stacks of Confocal Images

François Robin , Delphine Dauga , Olivier Tassy , Daniel Sobral , Fabrice Daian et al.
Cold Spring Harbor protocols, 2011, 2011 (10), pdb.prot065862. ⟨10.1101/pdb.prot065862⟩
Journal articles hal-03988953v1

Time-Lapse Imaging of Live Phallusia Embryos for Creating 3D Digital Replicas.

François Robin , Delphine Dauga , Olivier Tassy , Daniel Sobral , Fabrice Daian et al.
Cold Spring Harbor protocols, 2011, 2011 (10), pdb.prot065847. ⟨10.1101/pdb.prot065847⟩
Journal articles hal-03988971v1

The ANISEED database: Digital representation, formalization, and elucidation of a chordate developmental program

Olivier Tassy , Delphine Dauga , Fabrice Daian , Daniel Sobral , François Robin et al.
Genome Research, 2010, 20 (10), pp.1459-1468. ⟨10.1101/gr.108175.110⟩
Journal articles hal-03988928v1

The ANISEED database: digital representation, formalization, and elucidation of a chordate developmental program.

Olivier Tassy , Delphine Dauga , Fabrice Daian , Daniel Sobral , François Robin et al.
Genome Research, 2010, 20 (10), pp.1459-68. ⟨10.1101/gr.108175.110⟩
Journal articles hal-00586199v1

Sequential Activation of Apical and Basolateral Contractility Drives Ascidian Endoderm Invagination

Kristin Sherrard , François Robin , Patrick Lemaire , Edwin Munro
Current Biology - CB, 2010, 20 (17), pp.1499-1510. ⟨10.1016/j.cub.2010.06.075⟩
Journal articles hal-03990370v1

A Multicassette Gateway Vector Set for High Throughput and Comparative Analyses in Ciona and Vertebrate Embryos

Agnès Roure , Ute Rothbächer , François Robin , Eva Kalmar , Giustina Ferone et al.
PLoS ONE, 2007, 2 (9), pp.e916. ⟨10.1371/journal.pone.0000916⟩
Journal articles hal-03988902v1

Cellular morphogenesis in ascidians: how to shape a simple tadpole

Edwin Munro , François Robin , Patrick Lemaire
Current Opinion in Genetics and Development, 2006, 16 (4), pp.399-405. ⟨10.1016/j.gde.2006.06.004⟩
Journal articles hal-03990395v1

Cellular morphogenesis in ascidians: how to shape a simple tadpole

Edwin Munro , Francois Robin , Patrick Lemaire
Current Opinion in Genetics and Development, 2006, 16 (4), pp.399-405. ⟨10.1016/j.gde.2006.06.004⟩
Journal articles hal-01440654v1